pozanicline has been researched along with mecamylamine in 3 studies
| Studies (pozanicline) | Trials (pozanicline) | Recent Studies (post-2010) (pozanicline) | Studies (mecamylamine) | Trials (mecamylamine) | Recent Studies (post-2010) (mecamylamine) |
|---|---|---|---|---|---|
| 28 | 5 | 13 | 1,997 | 68 | 376 |
| Protein | Taxonomy | pozanicline (IC50) | mecamylamine (IC50) |
|---|---|---|---|
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | 0.44 | |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | 2.0833 | |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | 1.6133 | |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | 1.8 | |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | 0.6 | |
| Neuronal acetylcholine receptor subunit alpha-2 | Homo sapiens (human) | 3.1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dart, MJ; Holladay, MW; Lynch, JK | 1 |
| Arneric, SP; Briggs, CA; Gopalakrishnan, M; McKenna, DG; Monteggia, LM; Roch, JM; Sullivan, JP; Touma, E | 1 |
| Decker, MW; Man, K; Parikh, V; Sarter, M | 1 |
1 review(s) available for pozanicline and mecamylamine
| Article | Year |
|---|---|
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 1997 |
2 other study(ies) available for pozanicline and mecamylamine
| Article | Year |
|---|---|
Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Substitution; Animals; Atropine; Choline; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Genetic Variation; Humans; Lobeline; Mecamylamine; Membrane Potentials; Muscarinic Antagonists; Mutation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Pyridines; Pyrrolidines; Receptors, Nicotinic; Threonine; Tubocurarine; Valine; Xenopus | 1999 |
Glutamatergic contributions to nicotinic acetylcholine receptor agonist-evoked cholinergic transients in the prefrontal cortex.
Topics: Acetylcholine; Analysis of Variance; Animals; Choline; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Electrochemistry; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Male; Mecamylamine; Neostigmine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Pyridines; Pyrrolidines; Quinoxalines; Rats; Sodium Channel Blockers; Tetrodotoxin; Valine | 2008 |