povidone-iodine and benzoic-acid--malic-acid--propylene-glycol--salicylic-acid-drug-combination

A trial comparing three topical agents was carried out in patients with burns. The substances investigated were 10% povidone-iodine (PVP-I) ointment mixed with a proteolytic agent, 5% PVP-I cream alone and in combination with the same proteolytic agent. Differences were observed in healing times and bacteriological cultures. Shorter healing times were observed in burns treated with PVP-I cream. The addition of a proteolytic agent to the cream made no difference to the results. Fewer positive cultures for Staphylococcus aureus and Pseudomonas aeruginosa were obtained in the groups treated with the cream. It was concluded that 5% PVP-I cream is a safe and effective topical agent in burns.

Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Infective Agents, Local; Bacteria; Benzoates; Burns; Child; Child, Preschool; Clinical Trials as Topic; Dosage Forms; Drug Combinations; Humans; Infant; Malates; Middle Aged; Ointments; Povidone; Povidone-Iodine; Salicylates; Wound Healing

Topics: Anti-Infective Agents, Local; Benzoates; Borates; Clinical Protocols; Drug Combinations; Humans; Malates; Povidone-Iodine; Pressure Ulcer; Salicylates; Sodium Hypochlorite

This study has shown that Betadine cream with or without Aserbine is as easy to apply and remove as Betadine ointment plus Aserbine. With Betadine cream there is as good as and in some instances better healing than with Betadine ointment/Aserbine in the topical treatment of burns. However, the addition of a necrolytic cream to Betadine cream does have favourable effects on wound healing and bacterial counts. More importantly, this study suggests that Betadine cream can penetrate the wound more effectively than the Betadine ointment/Aserbine combination but that the addition of a necrolytic cream is still advantageous.

Topics: Administration, Topical; Adolescent; Adult; Aged; Benzoates; Burns; Child; Child, Preschool; Drug Combinations; Humans; Infant; Malates; Middle Aged; Ointments; Povidone; Povidone-Iodine; Salicylates; Wound Healing; Wound Infection

A remarkable improvement in the rate of burn healing has been achieved with a mixture of povidone-iodine ointment (Betadine) and malic, benzoic and salicylic acids (MBS) (Aserbine). A study was undertaken to compare the effects of a new povidone-iodine formulation (Betadine cream) with and without MBS with povidone-iodine ointment plus MBS. All preparations were easy to apply and were readily removed, causing only mild discomfort on application in the majority of cases. A significant difference in healing times was observed between povidone-iodine cream and povidone-iodine cream plus MBS. There was also a significant difference in the decrease in the number of positive bacterial cultures between these two treatments. This applied to both superficial and deep burns. No skin sensitivity reactions were reported with any of the preparations. The addition of MBS to povidone-iodine cream did not produce as significant an improvement in results as its addition to povidone-iodine ointment.

Topics: Administration, Topical; Adolescent; Adult; Anti-Infective Agents, Local; Benzoates; Burns; Drug Combinations; Humans; Malates; Ointments; Povidone; Povidone-Iodine; Salicylates; Time Factors; Wound Healing; Wound Infection