povidone-iodine and aluminum-acetate

The treatment of MRSA (methocillin resistant staphylococcus aureus) colonized middle ear is difficult. According to the guidelines, a MRSA colonized Patient is not to be treated with systemic antibiotics. The topical treatment shows the problem of the ototoxicity of most of the used antiseptic as well as antibiotic substances.. Selective literature review and consideration of the author's own clinical experience.. Antibiotic treatment options include aequeous Tetracyclin drops, aequeous chloramphenicol drops and quinolon ear drops (unfortunately the MRSA is resistent mostly). Antiseptics without ototoxic effects are the Burow's solution, Povidone-iode, acetic acid solutions and aequeous dequalinium solutions.

Topics: Acetates; Acetic Acid; Administration, Topical; Aged; Anti-Bacterial Agents; Anti-Infective Agents, Local; Chloramphenicol; Dequalinium; Guideline Adherence; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Ear Ventilation; Otitis Media with Effusion; Parotid Neoplasms; Pharmaceutical Solutions; Postoperative Complications; Povidone-Iodine; Quinolones; Staphylococcal Infections; Tetracycline

To determine the efficacy of Burow's solution as an otologic preparation for the treatment of chronic ear infection.. Two studies were included: 1) a prospective clinical study and 2) a laboratory study on antibacterial and antifungal effects.. A private otology practice and a laboratory study.. Fifty-eight patients with refractory otorrhea.. Diagnosis by otoscopy, audiometry, and bacteriology.. Burow's solution was mixed in solutions with four organisms: methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Candida albicans, and Aspergillus. Soon after Burow's solution was mixed in the solutions with organisms, and 5, 10, and 20 minutes thereafter, the mixtures were cultured on agars. The numbers of the bacterial or fungal colonies were counted to evaluate the effect of Burow's solution.. Changes in the clinical findings of the ears, the symptom of otorrhea, and side effects were assessed.. Thirty-five (70%) of the 50 ears assessed were "cured" and 10 (20%) ears assessed were "improved." No significant side effect was observed. Regarding the laboratory study, the four organisms disappeared within 20 minutes after Burow's solution was mixed.. Burow's solution was considered to be an effective otologic preparation.

Topics: Acetates; Anti-Infective Agents, Local; Aspergillus; Candida albicans; Chronic Disease; Female; Humans; Male; Microbial Sensitivity Tests; Otitis Externa; Otitis Media; Povidone-Iodine; Prospective Studies; Staphylococcus aureus; Streptococcus pneumoniae

The authors report the results achieved in a controlled clinical study carried out for evaluating the efficacy of some topical preparations in the treatment of the so-called non-specific cervicovaginitis. The best results have been observed in 55 patients treated with a 0.1% benzydamine solution, whose efficacy was found to be significantly greater than that of povidone-iodine vaginal suppositories or a 0.2% aluminium acetate solution that were used in an additional 45 patients suffering from non-specific vulvovaginitis and exocervicitis, according to a fully randomized experimental study protocol. The results obtained in the non-selected population of the present study confirm the usefulness of benzydamine vaginal douches in the therapy of non-specific inflammations involving the lower female genital apparatus.

Topics: Acetates; Administration, Intravaginal; Adult; Benzydamine; Double-Blind Method; Female; Humans; Pessaries; Povidone-Iodine; Pyrazoles; Random Allocation; Therapeutic Irrigation; Uterine Cervicitis; Vaginitis