potassium-permanganate and adamantanecarboxylic-acid

potassium-permanganate has been researched along with adamantanecarboxylic-acid* in 1 studies

Other Studies

1 other study(ies) available for potassium-permanganate and adamantanecarboxylic-acid

Article	Year
A facile method for the synthesis of 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid and it's optimization. Pakistan journal of pharmaceutical sciences, 2018, Volume: 31, Issue:4 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid (IV), a key intermediate of saxagliptin for type 2 diabetes mellitus (T2DM), was prepared from 1-adamantanecarboxylic acid(I) via oxidation by potassium permanganate(KMnO4) to afford 3-hydroxy-1-adamantanecarboxylic acid (II), which was treated with a one-pot method to give 1-acetyl-3-hydroxyadamantane (III) followed by oxidation. Some key steps were optimized and the overall yield was about 51%. Topics: Acetates; Adamantane; Chemistry Techniques, Synthetic; Dipeptides; Hypoglycemic Agents; Molecular Structure; Potassium Permanganate	2018

Article

Year

A facile method for the synthesis of 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid and it's optimization.

Pakistan journal of pharmaceutical sciences, 2018, Volume: 31, Issue:4

2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid (IV), a key intermediate of saxagliptin for type 2 diabetes mellitus (T2DM), was prepared from 1-adamantanecarboxylic acid(I) via oxidation by potassium permanganate(KMnO4) to afford 3-hydroxy-1-adamantanecarboxylic acid (II), which was treated with a one-pot method to give 1-acetyl-3-hydroxyadamantane (III) followed by oxidation. Some key steps were optimized and the overall yield was about 51%.

Topics: Acetates; Adamantane; Chemistry Techniques, Synthetic; Dipeptides; Hypoglycemic Agents; Molecular Structure; Potassium Permanganate

2018