potassium-oxonate has been researched along with baicalein* in 1 studies
1 other study(ies) available for potassium-oxonate and baicalein
| Article | Year |
|---|---|
Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase.
Insufficient renal urate excretion and/or overproduction of uric acid (UA) are the dominant causes of hyperuricemia. Baicalein (BAL) is widely distributed in dietary plants and has extensive biological activities, including antioxidative, anti-inflammatory and antihypertensive activities.. To investigate the anti-hyperuricemic effects of BAL and the underlying mechanisms in vitro and in vivo.. We investigated the inhibitory effects of BAL on GLUT9 and URAT1 in vitro through electrophysiological experiments and. These results indicated that BAL exerts potent antihyperuricemic efects through renal UA excretal promotion and serum UA production. Thus, we propose that BAL may be a promising treatment for the prevention of hyperuricemia owing to its multitargeted inhibitory activity. Topics: Animals; Antioxidants; Disease Models, Animal; Enzyme Inhibitors; Flavanones; Glucose Transport Proteins, Facilitative; HEK293 Cells; Humans; Hyperuricemia; Kidney; Liver; Male; Mice; Molecular Docking Simulation; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Uric Acid; Xanthine Oxidase | 2021 |