potassium-fluoride has been researched along with trimethylsilyl-cyanide* in 1 studies
1 other study(ies) available for potassium-fluoride and trimethylsilyl-cyanide
| Article | Year |
|---|---|
A chemoselective Ugi-type reaction in water using TMSCN as a functional isonitrile equivalent: generation of heteroaromatic molecular diversity.
KF-mediated nucleophilic activation of TMSCN as a functional isonitrile equivalent establishes an efficient and chemoselective Ugi-type multicomponent reaction of a heterocyclic amidine and aldehyde with TMSCN in water. In this approach, the use of isocyanide is circumvented, known competing reactions are virtually eliminated, pure products are obtained by a non-chromatographic method, and therapeutically relevant and diverse N-fused 3-aminoimidazoles can be prepared from a wide variety of aldehydes and heterocyclic amidines. This reaction coupling with cascade cyclization provides various privileged tetracyclic heteroaromatic scaffolds. Topics: Aldehydes; Benzamidines; Cyanides; Cyclization; Fluorides; Imidazoles; Magnetic Resonance Spectroscopy; Molecular Structure; Nitriles; Potassium Compounds; Stereoisomerism; Trimethylsilyl Compounds; Water | 2012 |