potassium-bicarbonate and magnesium-carbonate

Alternative treatments are commonly used for various disorders and often taken on-demand. On-demand treatment of gastroesophageal reflux disease (GERD) with pharmaceutical products is an established, cost-effective strategy. Comparisons between alternative medicine and pharmaceutical products are rare. The aim of this trial was to compare on-demand treatment with a pectin-based, raft-forming, natural, anti-reflux agent (PRA) with that of esomeprazole 20 mg (Eso20) in patients with mild/moderate GERD.. Patients with mild/moderate GERD were randomised to a six weeks' on-demand treatment with PRA or Eso20 in a pragmatic, open, multicentre trial. Overall satisfaction with treatment, satisfactory relief on a weekly basis, reflux symptoms, and treatment preferences were noted.. Seventy-seven patients were included in the analyses. Eso20 was significantly superior to PRA for proportion of overall satisfied patients (92% and 58% respectively; p = 0.001), reduction of symptoms (mean symptom scores at the end 5.9 and 8.0 respectively; p = 0.019), proportion of weeks of satisfactory relief (89% and 62% respectively; p = 0.008) and proportion preferring continuation with the same treatment (85% and 42% respectively; p < 0.001). Older patients were more satisfied than younger, and patients preferring on-demand treatment had lower symptom scores at inclusion than those preferring regular treatment.. On-demand treatment with esomeprazole 20 mg was clearly superior to the pectin-based raft-forming agent. Most patients preferred on-demand treatment to regular treatment. Those preferring regular therapy had significantly more symptoms at inclusion.

Topics: Adult; Anti-Ulcer Agents; Bicarbonates; Complementary Therapies; Esomeprazole; Female; Gastroesophageal Reflux; Humans; Magnesium; Male; Middle Aged; Patient Satisfaction; Pectins; Potassium Compounds

The aim of this study was to evaluate the erosive/abrasive enamel wear after contact with orange juices modified with different dietary supplements.. A total of 96 bovine enamel samples were prepared and allocated to eight groups (1-8; n = 12). Samples were eroded (120 s) in 200 ml of the following eight solutions: 1: water (control), 2: orange juice, 3: water + calcium effervescent tablet, 4: orange juice + calcium effervescent tablet, 5: water + 0.75 g acid/base regulating powder (Probase), 6: water + 0.375 g Probase, 7: orange juice + 0.75 g Probase and 8: orange juice + 0.375 g Probase. After erosion, the samples were brushed with 40 brushing strokes (load 2.5 N). Enamel wear was measured using surface profilometry after 20 and 40 cycles of erosion/abrasion respectively.. Highest mean enamel wear (± SD) after 20 and 40 cycles of erosion/abrasion was observed for the unmodified orange juice (group 2) (0.605 ± 0.240 μm; 1.375 ± 0.496 μm respectively). The enamel wear in all other groups (3-8) was significantly lower (P < 0.0001 respectively) with no significant difference within these groups and compared with water (control).. Erosive/abrasive enamel wear induces by orange juice and tooth brushing could be reduced significantly by modification with free available dietary supplements.

Topics: Animals; Beverages; Bicarbonates; Calcium Carbonate; Calcium Fluoride; Calcium Phosphates; Calcium, Dietary; Cariostatic Agents; Cattle; Citrus sinensis; Dental Enamel; Diamines; Dietary Supplements; Durapatite; Fluorides; Fruit; Hardness; Hydrogen-Ion Concentration; Magnesium; Materials Testing; Potassium Compounds; Sodium Bicarbonate; Tooth Abrasion; Tooth Erosion; Toothbrushing; Toothpastes; Water