potassium-ascorbyl-tocopheryl-phosphate has been researched along with peroxynitric-acid* in 1 studies
1 other study(ies) available for potassium-ascorbyl-tocopheryl-phosphate and peroxynitric-acid
| Article | Year |
|---|---|
EPC-K1 attenuates peroxynitrite-induced apoptosis in cerebellar granule cells.
Apoptosis induced by peroxynitrite in cultured cerebellar granule cells was confirmed morphologically by chromatin condensation and biochemically by DNA laddering. A 30 min exposure to peroxynitrite (10 microM) initiated oxidative stress, which caused the formation of thiobarbituric acid-reactive substances (TBARS) and the alteration of cell membrane fluidity. Peroxynitrite treatment also caused ATP decrease and thus activated the apoptotic program. Pre-treating cells with antioxidant EPC-K1 (L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H -1- benzopyran-6-yl-hydrogen phosphate] potasium salt), a new water-soluble derivative of vitamin C and vitamin E, attenuated oxidative injury and prevents cells from apoptosis. The results suggest that EPC-K1 might be used as a potential therapeutic agent for diseases associated with NO/ONOO(-)-mediated neuronal injury. Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Cell Survival; Cells, Cultured; Cerebellum; DNA Fragmentation; Lipid Peroxidation; Membrane Fluidity; Neurons; Nitrates; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Vitamin E | 1998 |