potassium-ascorbyl-tocopheryl-phosphate and 5-5-dimethyl-1-pyrroline-1-oxide

potassium-ascorbyl-tocopheryl-phosphate has been researched along with 5-5-dimethyl-1-pyrroline-1-oxide* in 1 studies

Other Studies

1 other study(ies) available for potassium-ascorbyl-tocopheryl-phosphate and 5-5-dimethyl-1-pyrroline-1-oxide

Article	Year
Inhibitory effect of antioxidants on hydroxyl radical generation from methylguanidine: an ESR study. Neurochemical research, 2009, Volume: 34, Issue:4 Methylguanidine (MG) is known as not only a nephrotoxin but also as a neurotoxine. We have previously showed that MG itself generates hydroxyl radicals (OH) in an in vitro study. In this study, we examined the inhibitory effects of ascorbate, EPC-K(1) (alpha-tocopheryl-L-ascorbate-2-O-phosphate diester), Trolox (water-soluble vitamin E analogue), and glutathione (GSH) on OH generation from MG using an electron spin resonance (ESR) spectrometry with spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO). It was found that these compounds have potent inhibitory effect on *OH generation from MG in the order of ascorbate > GSH > EPC-K(1) > Trolox. Topics: Antioxidants; Ascorbic Acid; Chromans; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Glutathione; Hydroxyl Radical; Methylguanidine; Spin Trapping; Vitamin E	2009

Article

Year

Inhibitory effect of antioxidants on hydroxyl radical generation from methylguanidine: an ESR study.

Neurochemical research, 2009, Volume: 34, Issue:4

Methylguanidine (MG) is known as not only a nephrotoxin but also as a neurotoxine. We have previously showed that MG itself generates hydroxyl radicals (*OH) in an in vitro study. In this study, we examined the inhibitory effects of ascorbate, EPC-K(1) (alpha-tocopheryl-L-ascorbate-2-O-phosphate diester), Trolox (water-soluble vitamin E analogue), and glutathione (GSH) on *OH generation from MG using an electron spin resonance (ESR) spectrometry with spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO). It was found that these compounds have potent inhibitory effect on *OH generation from MG in the order of ascorbate > GSH > EPC-K(1) > Trolox.

Topics: Antioxidants; Ascorbic Acid; Chromans; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Glutathione; Hydroxyl Radical; Methylguanidine; Spin Trapping; Vitamin E

2009