Page last updated: 2024-08-16

ponalrestat and tolrestat

ponalrestat has been researched along with tolrestat in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (14.29)	18.7374
1990's	15 (71.43)	18.2507
2000's	3 (14.29)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Aldinger, CE; Beyer, TA; Dee, MF; Larson, ER; Mylari, BL; Siegel, TW; Singleton, DH; Zembrowski, WJ	1
Beyer, TA; Mylari, BL; Siegel, TW	1
Bauman, JG; Dietrich, A; Gorham, BJ; Harrison, MC; Jones, LR; Kelly, JM; Malamas, M; Millen, J; Sredy, J; Wrobel, J	1
DuPriest, MT; Griffin, BW; Kuzmich, D; McNatt, LG	1
Fujitani, B; Komiya, M; Kuromiya, A; Matsumoto, J; Murata, M; Negoro, T; Ono, Y; Suzuki, K; Ueda, S	1
Carper, DA; Hohman, TC; Kitchen, D; Malamas, MS; Nilakantan, R; Singh, SB	1
Collier, A; Small, M	1
Deck, LM; Hunsaker, LA; Robinson, B; Stangebye, LA; Vander Jagt, DL	1
Ansari, NH; Bhatnagar, A; Das, B; Liu, SQ; Srivastava, SK	1
Hunsaker, LA; Robinson, B; Taylor, KK; Vander Jagt, DL	1
Das, B; Liu, S; Srivastava, SK	1
Hotta, N; Sakamoto, N	1
Kador, PF; Kinoshita, JH; Sharpless, NE	1
Bannai, C; Itakura, M; Oda, A; Yamaoka, T; Yamashita, K	1
Calcutt, NA; Kalichman, MW; Mizisin, AP	1
Burnakis, TG; Tsai, SC	1
Carper, D; Sato, S; Sugiyama, K	1
Gelber, DA; Pfeifer, MA; Schumer, MP	1
Kador, PF; Lee, YS; Sato, S; Sugiyama, K	1
Chen, Z; Kador, PF; Lee, YS; Sugiyama, K	1
Blessing, K; Fujisawa, S; Kador, PF; Lee, JW; Lou, MF	1

Reviews

4 review(s) available for ponalrestat and tolrestat

Article	Year
[Clinical application of aldose reductase inhibitors--prevention and therapy of diabetic complications]. Nihon rinsho. Japanese journal of clinical medicine, 1987, Volume: 45, Issue:12 Topics: Aldehyde Reductase; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Humans; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Naphthalenes; Phthalazines; Sugar Alcohol Dehydrogenases	1987
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications. Journal of medicinal chemistry, 1985, Volume: 28, Issue:7 Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Fluorenes; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Models, Molecular; Naphthalenes; Phthalazines; Rhodanine; Sorbitol; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases; Thiazolidines; Tissue Distribution	1985
Aldose reductase inhibitors: an update. The Annals of pharmacotherapy, 1993, Volume: 27, Issue:6 Topics: Aldehyde Reductase; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Humans; Imidazoles; Imidazolidines; Isoquinolines; Naphthalenes; Phthalazines	1993
Aldose reductase inhibitors: the end of an era or the need for different trial designs? Diabetes, 1997, Volume: 46 Suppl 2 Topics: Aldehyde Reductase; Autonomic Nervous System; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Isoquinolines; Naphthalenes; Phthalazines; Time Factors	1997

Trials

1 trial(s) available for ponalrestat and tolrestat

Article	Year
Aldose reductase inhibitors: the end of an era or the need for different trial designs? Diabetes, 1997, Volume: 46 Suppl 2 Topics: Aldehyde Reductase; Autonomic Nervous System; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Isoquinolines; Naphthalenes; Phthalazines; Time Factors	1997

Other Studies

17 other study(ies) available for ponalrestat and tolrestat

Article	Year
Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners. Journal of medicinal chemistry, 1991, Volume: 34, Issue:1 Topics: Aldehyde Reductase; Animals; Benzothiazoles; Enzyme Inhibitors; Female; Humans; Indicators and Reagents; Kinetics; Lens, Crystalline; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Phthalazines; Placenta; Pregnancy; Rats; Structure-Activity Relationship; Thiazoles; X-Ray Diffraction	1991
A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners. Journal of medicinal chemistry, 1991, Volume: 34, Issue:3 Topics: Alcohol Dehydrogenase; Aldehyde Reductase; Animals; Chemical Phenomena; Chemistry; Diabetes Mellitus, Experimental; Female; Humans; Kidney; Lens, Crystalline; Molecular Structure; Placenta; Pyrrolidonecarboxylic Acid; Sciatic Nerve; Sorbitol; Structure-Activity Relationship; Swine	1991
Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives. Journal of medicinal chemistry, 1991, Volume: 34, Issue:8 Topics: Administration, Oral; Aldehyde Reductase; Animals; Cattle; Chemical Phenomena; Chemistry; Diabetes Mellitus, Experimental; Diaphragm; Galactitol; Galactose; Glycine; Lens, Crystalline; Male; Molecular Structure; Naphthalenes; Prodrugs; Rats; Rats, Inbred Strains; Sciatic Nerve	1991
Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors. Journal of medicinal chemistry, 1991, Volume: 34, Issue:11 Topics: Aldehyde Reductase; Animals; Carbohydrate Dehydrogenases; Enzyme Inhibitors; Rats; Spiro Compounds; Structure-Activity Relationship; Thiazoles	1991
Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners. Journal of medicinal chemistry, 1998, Oct-08, Volume: 41, Issue:21 Topics: Aldehyde Reductase; Animals; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Enzyme Inhibitors; In Vitro Techniques; Lens, Crystalline; Male; Molecular Conformation; Pyrazines; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Swine	1998
Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants. Journal of medicinal chemistry, 2000, Mar-23, Volume: 43, Issue:6 Topics: Aldehyde Reductase; Benzothiazoles; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Mutagenesis, Site-Directed; Phthalazines; Recombinant Proteins; Structure-Activity Relationship; Thiazoles	2000
The role of the polyol pathway in diabetes mellitus. British journal of hospital medicine, 1991, Volume: 45, Issue:1 Topics: Aldehyde Reductase; Diabetes Complications; Diabetes Mellitus; Glycolysis; Glycosylation; Humans; Hyperglycemia; Imidazoles; Imidazolidines; Naphthalenes; Phthalazines; Rhodanine; Thiazolidines	1991
Aldehyde and aldose reductases from human placenta. Heterogeneous expression of multiple enzyme forms. The Journal of biological chemistry, 1990, Jul-05, Volume: 265, Issue:19 Topics: Alcohol Dehydrogenase; Aldehyde Reductase; Chromatography, High Pressure Liquid; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Female; Glyceraldehyde; Humans; Hydrogen-Ion Concentration; Imidazoles; Imidazolidines; Immunoenzyme Techniques; Kinetics; NADP; Naphthalenes; Phthalazines; Placenta; Pregnancy; Substrate Specificity; Sugar Alcohol Dehydrogenases	1990
Inhibition kinetics of human kidney aldose and aldehyde reductases by aldose reductase inhibitors. Biochemical pharmacology, 1990, Mar-15, Volume: 39, Issue:6 Topics: Aldehyde Reductase; Aldehydes; Carbohydrate Dehydrogenases; Chromones; Humans; Imidazoles; Imidazolidines; Isoquinolines; Kidney; Kinetics; Naphthalenes; Phenobarbital; Phthalazines; Quercetin; Quinolones; Substrate Specificity; Sugar Alcohol Dehydrogenases	1990
Aldose reductase from human skeletal and heart muscle. Interconvertible forms related by thiol-disulfide exchange. The Journal of biological chemistry, 1990, Dec-05, Volume: 265, Issue:34 Topics: Aldehyde Reductase; Chromatography; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Durapatite; Humans; Hydroxyapatites; Imidazoles; Imidazolidines; Isoelectric Focusing; Isoenzymes; Kinetics; Molecular Weight; Muscles; Myocardium; Naphthalenes; Phthalazines	1990
The distribution of aldose reductase and aldehyde reductase II in different regions of bovine lens. Lens and eye toxicity research, 1989, Volume: 6, Issue:3 Topics: Alcohol Dehydrogenase; Aldehyde Reductase; Animals; Cattle; Chromatography, Ion Exchange; Epithelium; Fluorometry; Glutarates; Imidazoles; Imidazolidines; Kinetics; Lens Cortex, Crystalline; Lens Nucleus, Crystalline; Lens, Crystalline; Naphthalenes; Phenobarbital; Phthalazines; Spectrophotometry; Substrate Specificity	1989
The effect of non-enzymatic glycation on recombinant human aldose reductase. Diabetes research and clinical practice, 1995, Volume: 27, Issue:3 Topics: Aldehyde Reductase; Enzyme Inhibitors; Fluorenes; Glucose; Glycosylation; Humans; Hydantoins; Imidazoles; Imidazolidines; Kinetics; Naphthalenes; Phthalazines; Recombinant Proteins; Substrate Specificity; Transfection	1995
Aldose reductase inhibition, Doppler flux and conduction in diabetic rat nerve. European journal of pharmacology, 1994, Jan-04, Volume: 251, Issue:1 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Female; Laser-Doppler Flowmetry; Motor Neurons; Naphthalenes; Neural Conduction; Phthalazines; Rats; Rats, Sprague-Dawley; Sciatic Nerve	1994
Aldose reductase as dihydrodiol dehydrogenase. Naphthoquinone formation by rat lens aldose reductase. Advances in experimental medicine and biology, 1997, Volume: 414 Topics: Aldehyde Reductase; Animals; Enzyme Inhibitors; Eye Proteins; Fluorenes; Hydantoins; Imidazoles; Imidazolidines; Lens, Crystalline; Naphthalenes; Naphthoquinones; Oxidoreductases; Phthalazines; Rats	1997
Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors. Experimental eye research, 1999, Volume: 68, Issue:5 Topics: Aldehyde Reductase; Animals; Cataract; Chromatography, High Pressure Liquid; Crystallins; Enzyme Inhibitors; Fluorenes; Hydantoins; Imidazoles; Imidazolidines; Lens, Crystalline; Naphthalenes; Naphthols; Naphthoquinones; Phthalazines; Rats; Spectrophotometry	1999
Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex. Biochemical pharmacology, 2000, Feb-15, Volume: 59, Issue:4 Topics: Aldehyde Reductase; Animals; Enzyme Inhibitors; Fluorenes; Humans; Hydantoins; Lens, Crystalline; Models, Molecular; Muscles; NADP; Naphthalenes; Phthalazines; Rats	2000
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:2 Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluorenes; Glutathione; Glycation End Products, Advanced; Glycosylation; Hydantoins; Lens, Crystalline; Naphthalenes; Phthalazines; Rats; Rats, Sprague-Dawley; Sorbitol; Spectrometry, Fluorescence	2000