ponalrestat has been researched along with sorbinil in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (25.00) | 18.7374 |
| 1990's | 19 (67.86) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aldinger, CE; Beyer, TA; Dee, MF; Larson, ER; Mylari, BL; Siegel, TW; Singleton, DH; Zembrowski, WJ | 1 |
| Beyer, TA; Mylari, BL; Siegel, TW | 1 |
| Bauman, JG; Dietrich, A; Gorham, BJ; Harrison, MC; Jones, LR; Kelly, JM; Malamas, M; Millen, J; Sredy, J; Wrobel, J | 1 |
| DuPriest, MT; Griffin, BW; Kuzmich, D; McNatt, LG | 1 |
| Carper, DA; Hohman, TC; Kitchen, D; Malamas, MS; Nilakantan, R; Singh, SB | 1 |
| Degliesposti, G; Ferrari, AM; Rastelli, G; Sgobba, M | 1 |
| Beyer-Mears, A; Cruz, E; Murray, FT; Rountree, J; Sciadini, M | 1 |
| Collier, A; Small, M | 1 |
| Allen, T; Chang, WP; Cooper, M; Dimitriadis, E; Dunlop, ME; Larkins, RG | 1 |
| Deck, LM; Hunsaker, LA; Robinson, B; Stangebye, LA; Vander Jagt, DL | 1 |
| Ansari, NH; Bhatnagar, A; Das, B; Liu, SQ; Srivastava, SK | 1 |
| Hunsaker, LA; Robinson, B; Taylor, KK; Vander Jagt, DL | 1 |
| Das, B; Liu, S; Srivastava, SK | 1 |
| Poulsom, R | 4 |
| Hotta, N; Sakamoto, N | 1 |
| Kador, PF; Kinoshita, JH; Sharpless, NE | 1 |
| Bannai, C; Itakura, M; Oda, A; Yamaoka, T; Yamashita, K | 1 |
| Lightman, S | 1 |
| Coleman, MD; Jacobus, DP; Simpson, J | 1 |
| Hunsaker, LA; Kolb, NS; Vander Jagt, DL | 1 |
| Burnakis, TG; Tsai, SC | 1 |
| Krans, HM | 1 |
| Carper, D; Sato, S; Sugiyama, K | 1 |
| Gelber, DA; Pfeifer, MA; Schumer, MP | 1 |
| Kador, PF; Lee, YS; Sato, S; Sugiyama, K | 1 |
6 review(s) available for ponalrestat and sorbinil
| Article | Year |
|---|---|
[Clinical application of aldose reductase inhibitors--prevention and therapy of diabetic complications].
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Humans; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Naphthalenes; Phthalazines; Sugar Alcohol Dehydrogenases | 1987 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Fluorenes; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Models, Molecular; Naphthalenes; Phthalazines; Rhodanine; Sorbitol; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases; Thiazolidines; Tissue Distribution | 1985 |
Does aldose reductase have a role in the development of the ocular complications of diabetes?
Topics: Aldehyde Reductase; Animals; Cataract; Clinical Trials as Topic; Corneal Diseases; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Humans; Imidazoles; Imidazolidines; Lens, Crystalline; Phthalazines; Rats; Retinal Vessels | 1993 |
Aldose reductase inhibitors: an update.
Topics: Aldehyde Reductase; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Humans; Imidazoles; Imidazolidines; Isoquinolines; Naphthalenes; Phthalazines | 1993 |
Recent clinical experience with aldose reductase inhibitors.
Topics: Aldehyde Reductase; Biopsy; Diabetic Neuropathies; Double-Blind Method; Humans; Imidazoles; Imidazolidines; Neural Conduction; Peripheral Nerves; Phthalazines; Placebos; Vagus Nerve | 1993 |
Aldose reductase inhibitors: the end of an era or the need for different trial designs?
Topics: Aldehyde Reductase; Autonomic Nervous System; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Isoquinolines; Naphthalenes; Phthalazines; Time Factors | 1997 |
2 trial(s) available for ponalrestat and sorbinil
| Article | Year |
|---|---|
Recent clinical experience with aldose reductase inhibitors.
Topics: Aldehyde Reductase; Biopsy; Diabetic Neuropathies; Double-Blind Method; Humans; Imidazoles; Imidazolidines; Neural Conduction; Peripheral Nerves; Phthalazines; Placebos; Vagus Nerve | 1993 |
Aldose reductase inhibitors: the end of an era or the need for different trial designs?
Topics: Aldehyde Reductase; Autonomic Nervous System; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Isoquinolines; Naphthalenes; Phthalazines; Time Factors | 1997 |
22 other study(ies) available for ponalrestat and sorbinil
| Article | Year |
|---|---|
Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Enzyme Inhibitors; Female; Humans; Indicators and Reagents; Kinetics; Lens, Crystalline; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Phthalazines; Placenta; Pregnancy; Rats; Structure-Activity Relationship; Thiazoles; X-Ray Diffraction | 1991 |
A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners.
Topics: Alcohol Dehydrogenase; Aldehyde Reductase; Animals; Chemical Phenomena; Chemistry; Diabetes Mellitus, Experimental; Female; Humans; Kidney; Lens, Crystalline; Molecular Structure; Placenta; Pyrrolidonecarboxylic Acid; Sciatic Nerve; Sorbitol; Structure-Activity Relationship; Swine | 1991 |
Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Cattle; Chemical Phenomena; Chemistry; Diabetes Mellitus, Experimental; Diaphragm; Galactitol; Galactose; Glycine; Lens, Crystalline; Male; Molecular Structure; Naphthalenes; Prodrugs; Rats; Rats, Inbred Strains; Sciatic Nerve | 1991 |
Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors.
Topics: Aldehyde Reductase; Animals; Carbohydrate Dehydrogenases; Enzyme Inhibitors; Rats; Spiro Compounds; Structure-Activity Relationship; Thiazoles | 1991 |
Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants.
Topics: Aldehyde Reductase; Benzothiazoles; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Mutagenesis, Site-Directed; Phthalazines; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2000 |
Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.
Topics: Aldehyde Reductase; Binding Sites; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Inhibitory Concentration 50; Models, Biological; Molecular Structure; Thermodynamics | 2007 |
Comparison of sorbinil and ponalrestat (Statil) diminution of proteinuria in the BB rat.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 1; Imidazoles; Imidazolidines; Male; Phthalazines; Proteinuria; Rats; Rats, Inbred BB | 1992 |
The role of the polyol pathway in diabetes mellitus.
Topics: Aldehyde Reductase; Diabetes Complications; Diabetes Mellitus; Glycolysis; Glycosylation; Humans; Hyperglycemia; Imidazoles; Imidazolidines; Naphthalenes; Phthalazines; Rhodanine; Thiazolidines | 1991 |
The effect of aldose reductase inhibitors on glomerular prostaglandin production and urinary albumin excretion in experimental diabetes mellitus.
Topics: 6-Ketoprostaglandin F1 alpha; Albuminuria; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Hypoglycemic Agents; Imidazoles; Imidazolidines; Kidney Glomerulus; Male; Phthalazines; Prostaglandins E; Rats; Rats, Inbred Strains; Reference Values | 1991 |
Aldehyde and aldose reductases from human placenta. Heterogeneous expression of multiple enzyme forms.
Topics: Alcohol Dehydrogenase; Aldehyde Reductase; Chromatography, High Pressure Liquid; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Female; Glyceraldehyde; Humans; Hydrogen-Ion Concentration; Imidazoles; Imidazolidines; Immunoenzyme Techniques; Kinetics; NADP; Naphthalenes; Phthalazines; Placenta; Pregnancy; Substrate Specificity; Sugar Alcohol Dehydrogenases | 1990 |
Inhibition kinetics of human kidney aldose and aldehyde reductases by aldose reductase inhibitors.
Topics: Aldehyde Reductase; Aldehydes; Carbohydrate Dehydrogenases; Chromones; Humans; Imidazoles; Imidazolidines; Isoquinolines; Kidney; Kinetics; Naphthalenes; Phenobarbital; Phthalazines; Quercetin; Quinolones; Substrate Specificity; Sugar Alcohol Dehydrogenases | 1990 |
Aldose reductase from human skeletal and heart muscle. Interconvertible forms related by thiol-disulfide exchange.
Topics: Aldehyde Reductase; Chromatography; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Durapatite; Humans; Hydroxyapatites; Imidazoles; Imidazolidines; Isoelectric Focusing; Isoenzymes; Kinetics; Molecular Weight; Muscles; Myocardium; Naphthalenes; Phthalazines | 1990 |
The distribution of aldose reductase and aldehyde reductase II in different regions of bovine lens.
Topics: Alcohol Dehydrogenase; Aldehyde Reductase; Animals; Cattle; Chromatography, Ion Exchange; Epithelium; Fluorometry; Glutarates; Imidazoles; Imidazolidines; Kinetics; Lens Cortex, Crystalline; Lens Nucleus, Crystalline; Lens, Crystalline; Naphthalenes; Phenobarbital; Phthalazines; Spectrophotometry; Substrate Specificity | 1989 |
Inhibition of hexonate dehydrogenase and aldose reductase from bovine retina by sorbinil, statil, M79175 and valproate.
Topics: Aldehyde Reductase; Animals; Carbohydrate Dehydrogenases; Cattle; Imidazoles; Imidazolidines; In Vitro Techniques; Kinetics; Male; Molecular Conformation; Phthalazines; Pyridazines; Retina; Sugar Alcohol Dehydrogenases; Valproic Acid; Vitamin K | 1986 |
Inhibition of aldose reductase from human retina.
Topics: Aged; Aldehyde Reductase; Chemical Fractionation; Chromatography; Humans; Imidazoles; Imidazolidines; Middle Aged; Phthalazines; Retina; Sugar Alcohol Dehydrogenases | 1987 |
Comparison of aldose reductase inhibitors in vitro. Effects of enzyme purification and substrate type.
Topics: Aldehyde Reductase; Animals; Benzaldehydes; Cattle; Glucose; Imidazoles; Imidazolidines; Lens, Crystalline; Phthalazines; Sugar Alcohol Dehydrogenases | 1987 |
Aldose reductases from human retina and bovine lens: dependence of inhibition upon the choice of enzyme substrate.
Topics: Aldehyde Reductase; Animals; Cattle; Female; Humans; Imidazoles; Imidazolidines; Kinetics; Lens, Crystalline; Male; Phthalazines; Quercetin; Retina; Substrate Specificity; Sugar Alcohol Dehydrogenases | 1987 |
The effect of non-enzymatic glycation on recombinant human aldose reductase.
Topics: Aldehyde Reductase; Enzyme Inhibitors; Fluorenes; Glucose; Glycosylation; Humans; Hydantoins; Imidazoles; Imidazolidines; Kinetics; Naphthalenes; Phthalazines; Recombinant Proteins; Substrate Specificity; Transfection | 1995 |
Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro. III: Effect of diabetes.
Topics: Dapsone; Diabetes Mellitus; Ditiocarb; Erythrocytes; Glutathione; Humans; Imidazoles; Imidazolidines; Methemoglobin; Models, Chemical; Oxidation-Reduction; Phthalazines; Temperature | 1994 |
Aldose reductase-catalyzed reduction of acrolein: implications in cyclophosphamide toxicity.
Topics: Acrolein; Aldehyde Reductase; Cyclophosphamide; Enzyme Activation; Humans; Imidazoles; Imidazolidines; Muscles; Oxidation-Reduction; Phthalazines; Substrate Specificity | 1994 |
Aldose reductase as dihydrodiol dehydrogenase. Naphthoquinone formation by rat lens aldose reductase.
Topics: Aldehyde Reductase; Animals; Enzyme Inhibitors; Eye Proteins; Fluorenes; Hydantoins; Imidazoles; Imidazolidines; Lens, Crystalline; Naphthalenes; Naphthoquinones; Oxidoreductases; Phthalazines; Rats | 1997 |
Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Cataract; Chromatography, High Pressure Liquid; Crystallins; Enzyme Inhibitors; Fluorenes; Hydantoins; Imidazoles; Imidazolidines; Lens, Crystalline; Naphthalenes; Naphthols; Naphthoquinones; Phthalazines; Rats; Spectrophotometry | 1999 |