Page last updated: 2024-09-04

pomalidomide and ixazomib

pomalidomide has been researched along with ixazomib in 9 studies

Compound Research Comparison

Studies
(pomalidomide)
Trials
(pomalidomide)
Recent Studies (post-2010)
(pomalidomide)
Studies
(ixazomib)
Trials
(ixazomib)
Recent Studies (post-2010) (ixazomib)
62312155230078289

Protein Interaction Comparison

ProteinTaxonomypomalidomide (IC50)ixazomib (IC50)
Proteasome subunit beta type-11Homo sapiens (human)0.015
Proteasome subunit alpha type-7Homo sapiens (human)0.015
Proteasome subunit beta type-1Homo sapiens (human)0.0163
Proteasome subunit alpha type-1Homo sapiens (human)0.015
Proteasome subunit alpha type-2Homo sapiens (human)0.015
Proteasome subunit alpha type-3Homo sapiens (human)0.015
Proteasome subunit alpha type-4Homo sapiens (human)0.015
Proteasome subunit beta type-8Homo sapiens (human)0.015
Proteasome subunit beta type-9Homo sapiens (human)0.015
Proteasome subunit alpha type-5Homo sapiens (human)0.015
Proteasome subunit beta type-4Homo sapiens (human)0.015
Proteasome subunit beta type-6Homo sapiens (human)0.015
Proteasome subunit beta type-5Homo sapiens (human)0.0065
Proteasome subunit beta type-10Homo sapiens (human)0.015
Proteasome subunit beta type-3Homo sapiens (human)0.015
Proteasome subunit beta type-2Homo sapiens (human)1.1817
Proteasome subunit alpha type-6Homo sapiens (human)0.015
ATP-dependent Clp protease proteolytic subunitStaphylococcus aureus subsp. aureus NCTC 83255.3
NACHT, LRR and PYD domains-containing protein 3 Mus musculus (house mouse)0.1995
Proteasome subunit alpha-type 8Homo sapiens (human)0.015
Proteasome subunit beta type-7Homo sapiens (human)0.015

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (44.44)24.3611
2020's5 (55.56)2.80

Authors

AuthorsStudies
Chen, W; Li, J; Liu, X; Shi, J; Zhang, Z; Zhao, L; Zhou, Y1
Jung, CK; Jung, Y; Kang, SW; Kim, BG; Kim, TH; Lee, SE; Lim, JY; Min, CK; Park, E; Park, J; Won, KA1
Boccadoro, M; Bonello, F; Larocca, A; Salvini, M1
Costello, C; Mikhael, JR1
Joseph, NS; Kaufman, JL1
Chung, DJ; Diamond, B; Lesokhin, AM; Maclachlan, K; Ola Landgren, C1
Aslam, M; Atenafu, EG; Cherniawsky, H; Gul, E; Jimenez-Zepeda, VH; Kotb, R; LeBlanc, R; Louzada, ML; Masih-Khan, E; McCurdy, A; Reece, DE; Reiman, A; Sebag, M; Song, K; Stakiw, J; Venner, CP; White, D1
Bova-Solem, M; Carlisle, D; Efebera, YA; Hassoun, H; Laubach, JP; McCarthy, PL; Mulkey, F; Richardson, PG; Santo, K; Suman, VJ; Tuchman, SA; Voorhees, PM1
Darif, M; Demarquette, H; Dimopoulos, MA; Doronin, V; Du, J; Fenk, R; Kumar, S; Labotka, R; Lee, C; Leleu, X; Levin, MD; Mellqvist, UH; Montes, YG; Pompa, A; Quach, H; Ramasamy, K; Sati, H; Schjesvold, F; Vinogradova, O; Vorog, A1

Reviews

4 review(s) available for pomalidomide and ixazomib

ArticleYear
A review on the treatment of multiple myeloma with small molecular agents in the past five years.
    European journal of medicinal chemistry, 2022, Feb-05, Volume: 229

    Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Combined Modality Therapy; Deubiquitinating Enzymes; Drug Development; Drug Resistance; Histone Deacetylases; Humans; Ikaros Transcription Factor; Immunomodulating Agents; Models, Molecular; Morpholines; Multiple Myeloma; Phthalimides; Piperidones; Proteasome Inhibitors; Treatment Outcome; Ubiquitin-Protein Ligases

2022
Management of adverse events induced by next-generation immunomodulatory drug and proteasome inhibitors in multiple myeloma.
    Expert review of anticancer therapy, 2017, Volume: 17, Issue:1

    Topics: Antineoplastic Agents; Boron Compounds; Dose-Response Relationship, Drug; Glycine; Humans; Immunologic Factors; Multiple Myeloma; Oligopeptides; Proteasome Inhibitors; Survival Rate; Thalidomide

2017
Novel Approaches for the Management of AL Amyloidosis.
    Current hematologic malignancy reports, 2018, Volume: 13, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Boron Compounds; Glycine; Humans; Immunoglobulin Light-chain Amyloidosis; Magnetic Resonance Imaging; Prognosis; Thalidomide

2018
Maintenance therapy and need for cessation studies in multiple myeloma: Focus on the future.
    Best practice & research. Clinical haematology, 2020, Volume: 33, Issue:1

    Topics: Adaptive Clinical Trials as Topic; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Boron Compounds; Bortezomib; Disease-Free Survival; Drug Administration Schedule; Glycine; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Maintenance Chemotherapy; Multiple Myeloma; Neoplasm, Residual; Oligopeptides; Thalidomide; Transplantation, Autologous; Withholding Treatment

2020

Trials

2 trial(s) available for pomalidomide and ixazomib

ArticleYear
A phase I/II study of ixazomib, pomalidomide, and dexamethasone for lenalidomide and proteasome inhibitor refractory multiple myeloma (Alliance A061202).
    American journal of hematology, 2021, 12-01, Volume: 96, Issue:12

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Boron Compounds; Dexamethasone; Drug Resistance, Neoplasm; Female; Glycine; Humans; Lenalidomide; Male; Maximum Tolerated Dose; Middle Aged; Multiple Myeloma; Proteasome Inhibitors; Thalidomide

2021
Oral ixazomib-dexamethasone vs oral pomalidomide-dexamethasone for lenalidomide-refractory, proteasome inhibitor-exposed multiple myeloma: a randomized Phase 2 trial.
    Blood cancer journal, 2022, 01-24, Volume: 12, Issue:1

    Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Boron Compounds; Dexamethasone; Disease-Free Survival; Female; Glycine; Humans; Lenalidomide; Male; Middle Aged; Multiple Myeloma; Progression-Free Survival; Proteasome Inhibitors; Thalidomide

2022

Other Studies

3 other study(ies) available for pomalidomide and ixazomib

ArticleYear
Oral proteasome inhibitor with strong preclinical efficacy in myeloma models.
    BMC cancer, 2016, Mar-24, Volume: 16

    Topics: Aged; Animals; Antineoplastic Agents; Apoptosis; Boron Compounds; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Female; Glycine; Humans; Male; Mice; Middle Aged; Multiple Myeloma; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Thalidomide; Xenograft Model Antitumor Assays

2016
Therapy sequencing strategies in multiple myeloma: who, what and why?
    Future oncology (London, England), 2018, Volume: 14, Issue:2

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Boron Compounds; Glycine; Humans; Hydroxamic Acids; Indoles; Multiple Myeloma; Oligopeptides; Panobinostat; Thalidomide

2018
Retrospective study of treatment patterns and outcomes post-lenalidomide for multiple myeloma in Canada.
    European journal of haematology, 2021, Volume: 107, Issue:4

    Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Boron Compounds; Bortezomib; Canada; Dexamethasone; Female; Glycine; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Maintenance Chemotherapy; Male; Middle Aged; Multiple Myeloma; Oligopeptides; Recurrence; Retrospective Studies; Salvage Therapy; Survival Analysis; Thalidomide; Transplantation, Autologous

2021