polygalacturonic-acid and 1-2-dipalmitoylphosphatidylglycerol

polygalacturonic-acid has been researched along with 1-2-dipalmitoylphosphatidylglycerol* in 1 studies

Other Studies

1 other study(ies) available for polygalacturonic-acid and 1-2-dipalmitoylphosphatidylglycerol

Article	Year
Liposomal modification with uronate, which endows liposomes with long circulation in vivo, reduces the uptake of liposomes by J774 cells in vitro. Life sciences, 1992, Volume: 50, Issue:23 For overcoming rapid removal of liposomes from the bloodstream, we developed reticuloendothelial system (RES)-avoiding liposomes modified with a uronic acid derivative, palmityl-D-glucuronide (PGlcUA). In this current study, we examined the in vitro interaction of PGlcUA-liposomes with J774 cells derived from mouse macrophages. Liposomal association with J774 cells at 37 degrees C did not increase compared with the binding at 4 degrees C when liposomes were modified with PGlcUA. RES-avoiding ability was not specifically endowed by glucuronate but by uronates in general, since palmityl-D-galacturonide showed a similar effect on liposomal clearance in vivo and liposomal uptake in vitro. These facts indicate that modification of the liposomal surface with uronic acid derivatives endows liposomes with a long circulation time in the bloodstream by reducing their uptake by macrophages. Topics: Animals; Cells, Cultured; Glucuronates; Hexuronic Acids; Liposomes; Macrophages; Mice; Mononuclear Phagocyte System; Phosphatidylglycerols; Rats	1992

Article

Year

Liposomal modification with uronate, which endows liposomes with long circulation in vivo, reduces the uptake of liposomes by J774 cells in vitro.

Life sciences, 1992, Volume: 50, Issue:23

For overcoming rapid removal of liposomes from the bloodstream, we developed reticuloendothelial system (RES)-avoiding liposomes modified with a uronic acid derivative, palmityl-D-glucuronide (PGlcUA). In this current study, we examined the in vitro interaction of PGlcUA-liposomes with J774 cells derived from mouse macrophages. Liposomal association with J774 cells at 37 degrees C did not increase compared with the binding at 4 degrees C when liposomes were modified with PGlcUA. RES-avoiding ability was not specifically endowed by glucuronate but by uronates in general, since palmityl-D-galacturonide showed a similar effect on liposomal clearance in vivo and liposomal uptake in vitro. These facts indicate that modification of the liposomal surface with uronic acid derivatives endows liposomes with a long circulation time in the bloodstream by reducing their uptake by macrophages.

Topics: Animals; Cells, Cultured; Glucuronates; Hexuronic Acids; Liposomes; Macrophages; Mice; Mononuclear Phagocyte System; Phosphatidylglycerols; Rats

1992