podophyllotoxin has been researched along with picropodophyllin in 119 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.84) | 18.7374 |
| 1990's | 3 (2.52) | 18.2507 |
| 2000's | 40 (33.61) | 29.6817 |
| 2010's | 63 (52.94) | 24.3611 |
| 2020's | 12 (10.08) | 2.80 |
| Authors | Studies |
|---|---|
| Brewer, CF; Gensler, WJ; Horwitz, SB; Loike, JD; Sternlicht, H | 1 |
| Castro, MA; Gordaliza, M; Lopez, JL; Miguel del Corral, JM; Morales, LJ; San Feliciano, A | 1 |
| Charlton, JL | 1 |
| Abad, A; de Pascual-Teresa, B; del Olmo, E; López-Pérez, JL; San Feliciano, A | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Berkowitz, DB; Choi, S; Maeng, JH | 1 |
| Cui, YJ; Fei, XY; Guo, DA; Guo, HZ; Zheng, JH | 1 |
| Casey, M; Keaveney, CM | 1 |
| Axelson, M; Girnita, A; Girnita, L; Larsson, O; Vasilcanu, D; Vasilcanu, R | 1 |
| Axelson, M; Biberfeld, P; Brismar, K; Catrina, SB; Dricu, A; Grünler, J; Lewitt, M; Massambu, C | 1 |
| Axelson, M; Girnita, A; Girnita, L; Hillman, J; Karström, A; Kratz, G; Larsson, O; Thoren, M; Ulfarsson, E; Vasilcanu, D; Yin, S | 1 |
| Asosingh, K; Axelson, M; De Raeve, H; Girnita, L; Jernberg-Wiklund, H; Larsson, O; Menu, E; Nilsson, K; Stromberg, T; Van Camp, B; Vanderkerken, K | 1 |
| Axelson, M; Carlson, K; Dimberg, LY; Ekman, S; Girnita, L; Hellman, U; Jernberg-Wiklund, H; Larsson, O; Lennartsson, J; Nilsson, K; Osterborg, A; Strömberg, T; Vanderkerken, K | 1 |
| Axelson, M; Girnita, A; Girnita, L; Larsson, C; Larsson, O; Lui, WO; Vasilcanu, D; Vasilcanu, R; Weng, WH | 1 |
| All-Ericsson, C; Aström, K; Axelson, M; Economou, MA; Girnita, A; Girnita, L; Larsson, O; Seregard, S | 2 |
| Garcia-Echeverria, C | 1 |
| Axelson, M; Fickenscher, S; Girnita, A; Girnita, L; Larsson, O; Natalishvili, N; Naughton, S; Rosengren, L; Sehat, B; Vasilcanu, D; Vasilcanu, R; Yin, S | 1 |
| Axelson, M; Biberfeld, P; Botusan, IR; Brismar, K; Catrina, AI; Catrina, SB; Poellinger, L; Pyakurel, P; Rantanen, A; Savu, O | 1 |
| Axelson, M; Carlsson-Skwirut, C; Colón, E; Larsson, O; Söder, O; Svechnikov, KV; Zaman, F | 1 |
| Bernabei, P; Chiarle, R; Conti, L; Giovarelli, M; Longo, A; Novelli, F; Regis, G | 1 |
| Gupta, RS; Linder, S; Shoshan, MC | 1 |
| Jernberg-Wiklund, H; Nilsson, K | 1 |
| Axelson, M; Coulton, L; Croucher, P; De Leenheer, E; De Raeve, H; Gallagher, O; Jernberg-Wiklund, H; Larsson, O; Menu, E; Nilsson, K; Van Camp, B; Van Valckenborgh, E; Vanderkerken, K | 1 |
| Axelson, M; Girnita, L; Hedin, U; Henderson, B; Larsson, O; Razuvaev, A; Roy, J | 1 |
| Chakraborty, C; Nicola, C; Shields, SK | 1 |
| Bertrand, L; Deldicque, L; Francaux, M; Hespel, P; Hue, L; Theisen, D | 1 |
| Axelson, M; Girnita, A; Girnita, L; Larsson, O; Natalishvili, N; Rosengren, L; Sehat, B; Vasilcanu, D; Vasilcanu, R; Yin, S | 1 |
| Pullin, RD; Sellars, JD; Steel, PG | 1 |
| Banie, L; Fandel, T; Lin, CS; Lin, G; Lue, TF; Ning, H | 1 |
| Axelson, M; Girnita, A; Girnita, L; Sehat, B; Vasilcanu, D; Vasilcanu, R; Yin, S | 1 |
| Caidahl, K; Hedin, U; Lund, K; Razuvaev, A; Roy, J | 1 |
| All-Ericsson, C; Andersson, S; Axelson, M; Economou, MA; Girnita, A; Girnita, L; Larsson, O; Menu, E; Seregard, S; Vasilcanu, D | 2 |
| All-Ericsson, C; Axelson, M; Economou, MA; Girnita, L; Kvanta, A; Larsson, O; Menu, E; Rosengren, L; Seregard, S; van der Ploeg, I; Vasilcanu, D; Wu, J | 2 |
| Bissinger, M; Breuhahn, K; Ehemann, V; Gretz, N; Khamidjanov, A; Nussbaum, T; Ryschich, E; Samarin, J; Schirmacher, P; Yu, X | 1 |
| Girnita, L; Kammerer, C; Lopes, D; Madec, D; Poli, G; Prestat, G; Vitale, M | 1 |
| Economou, MA | 1 |
| Li, Y; Tang, YJ; Zhong, JJ | 1 |
| Chen, G; Efstratiadis, A; Hibshoosh, H; Klinakis, A; Szabolcs, M; Xuan, S | 1 |
| Fan, PC; Liu, X; Liu, ZL; Tian, X; Zhan, YJ; Zhang, ZW; Zhao, L | 1 |
| Choy, E; Duan, Z; Harmon, D; Hornicek, FJ; Mankin, H; Ryu, K; Schwab, J; Yang, C | 1 |
| Bruno, V; Caraci, F; Cataldo, S; Copani, A; De Bona, P; Garozzo, D; Giuffrida, ML; Messina, A; Molinaro, G; Nicoletti, F; Palmigiano, A; Pappalardo, G; Pignataro, B; Rizzarelli, E | 1 |
| Axelson, M; Danielsson, KG; Danielsson, O; Inzunza, J; Lalitkumar, PG; Larsson, O; Stavreus-Evers, A; Töhönen, V | 1 |
| Andersson, S; Axelson, M; Ekström, TJ; Ericsson, C; Girnita, A; Girnita, L; Khan, Z; Larsson, O; Nistér, M; Strömberg, T; Yin, S; Zheng, H | 1 |
| Ballock, RT; Shao, YY; Wang, L | 1 |
| Shinozaki, F; Sueishi, M; Sugiyama, T; Tomizawa, M; Yamamoto, S; Yoshida, T | 1 |
| Hei, TK; Ivanov, VN; Karasic, TB | 1 |
| Hosoyama, T; Keller, C; Nelon, LD; Ohshima-Hosoyama, S | 1 |
| Bagnoli, P; Cammalleri, M; Dal Monte, M; Filippi, L; Fiorini, P; Fortunato, P; la Marca, G; Martini, D; Ristori, C | 1 |
| Axelson, M; Beck, O; Bergqvist, M; Ekman, S; Eksborg, S; Harmenberg, J; Rönquist-Nii, Y | 1 |
| Amaya, F; Izumi, Y; Miura, M; Mizukoshi, K; Sasaki, M; Shibasaki, M; Shimosato, G | 1 |
| Amin, HM; Manshouri, R; Schlette, EJ; Shi, P; Vega, F; Vishwamitra, D; Wilson, D | 1 |
| Axelson, M; Fryknäs, M; Girnita, L; Hashemi, J; Jernberg-Wiklund, H; Karimi, M; Larsson, C; Larsson, O; Lui, WO; Rudduck, C; Sulaiman, L; Vasilcanu, D; Weng, WH; Worrall, C | 1 |
| Aleem, E; Axelson, M; Feng, X; Larsson, O; Lin, Y; Strömberg, T | 1 |
| Abraham, J; Hawkins, DS; Keller, C; Malempati, S; McHardy, SF; Michalek, JE; Nelon, LD; Prajapati, SI; Soundararajan, A; Zarzabal, LA | 1 |
| Pandey, A; Piecewicz, SM; Roy, B; Sengupta, S; Xiang, SH; Zetter, BR | 1 |
| Agarwal, P; Atadja, P; Axelson, M; De Bruyne, E; Fristedt, C; Jernberg-Wiklund, H; Larsson, O; Lemaire, M; Menu, E; Österborg, A; Van Camp, B; Van Valckenborgh, E; Vanderkerken, K | 1 |
| Clayburgh, DR; Gross, ND; Koide, J; Proby, C; Wong, MH | 1 |
| Li, W; Ma, H; Pan, Y; Xing, C; Yu, X; Zhang, J | 1 |
| Bitton-Worms, K; Caspi, A; LeRoith, D; Rostoker, R; Shen-Orr, Z | 1 |
| Farnell, BM; Kim, DS; Mayanil, CS; Shim, KW; Tomita, T; Tsurubuchi, T; Xi, G | 1 |
| Chang, WW; Chang, WY; Fu, CH; Lai, A; Lin, RJ; Yu, AL; Yu, J; Yu, JC | 1 |
| Lu, X; Lv, J; Mei, J; Wang, L; Wang, X; Zhang, Q; Zhu, X | 1 |
| Dyrager, C; Fryknäs, M; Gullbo, J; Lennartsson, J; Sooman, L; Wickström, M; Wu, X | 1 |
| Dong, Z; Gu, X; Qiu, L; Shi, Y; Wang, L; Wu, W; Yan, X; Yao, D; Yao, M; Yao, N | 1 |
| Benabbou, N; Cadillon, M; Mirshahi, M; Mirshahi, P; Soria, J; Therwath, A | 1 |
| Guo, W; Tao, ZZ; Yin, SC | 1 |
| Chen, J; Dong, ZZ; Wang, L; Yan, MJ; Yan, XD; Yao, DF; Yao, M; Yao, NH | 1 |
| Bellail, AC; Hadjipanayis, CG; Hao, C; Li, C; Liu, T; Lv, G; Wang, Q; Wei, F; Zhang, G | 1 |
| Amin, HM; Fang, Z; Huang, Z; Shi, P; Zhen, H; Zhou, L | 1 |
| Chen, L; E, C; Li, J; Pan, Y; Shao, D; Zhang, D; Zhang, X | 1 |
| Diepstra, A; Liang, Z; Plattel, W; Van Den Berg, A; van Imhoff, G; Visser, L; Xu, C | 1 |
| Axelson, M; Bieghs, L; De Bruyne, E; Fostier, K; Jernberg-Wiklund, H; Johnsen, HE; Larsson, O; Lub, S; Maes, K; Menu, E; Nyegaard, M; Overgaard, MT; Schots, R; Van Valckenborgh, E; Vanderkerken, K | 1 |
| Luan, L; Wang, Y; Zhao, J | 1 |
| Benabbou, N; Bordu, C; Faussat, AM; Marie, JP; Mirshahi, M; Mirshahi, P; Soria, J; Tang, R; Therwath, A | 1 |
| Chaudhury, S; Gaikwad, SM; Jinager, A; Maheshwari, A; Ray, P; Singh, RK | 1 |
| Lubet, RA; Pan, J; Wang, Y; You, M; Zhang, Q | 1 |
| Abrahmsén, L; Akopyan, K; Aleem, E; Axelson, M; Larsson, O; Lindqvist, A; Parrow, V; Strömberg, T; Waraky, A | 1 |
| Han, C; Wang, S; Wang, X; Wu, Y | 1 |
| Bergqvist, M; Bergström, S; Brandén, E; Ekman, S; Harmenberg, J; Holgersson, G; Jerling, M; Klockare, M; Koyi, H; Larsson, O; Lundström, KL; Ringbom, M | 1 |
| Bian, YY; Chen, G; Diao, YM; Jiang, LH; Lu, DX; Luo, BX; Ren, L; Xia, BM; Xu, JY; Yang, NY; Yuan, XL; Zhang, CJ; Zhao, FM; Zheng, YY | 1 |
| Axelson, M; Berglund, M; Delforoush, M; Enblad, G; Feng, X; Georgii-Hemming, P; Larsson, O; Lennartsson, J; Lin, Y; Strömberg, T | 1 |
| Abrahmsen, L; Alvfors, C; Axelson, M; Bergqvist, M; Bergström, S; Ekman, S; Eksborg, S; Frödin, JE; Harmenberg, J; Hedlund, Å; Jerling, M; Larsson, O; Ståhl, B; Wassberg, C | 1 |
| Ben-Yosef, D; Dahan, A; Gawlik, A; Gepstein, V; Rozen, N; Shaoul, R; Tiosano, D; Verbitsky, O; Weisman, Y; Wildbaum, G | 1 |
| Gao, JJ; Miao, SW; Wang, BJ; Wu, YT | 1 |
| Cherpelis, B; Rudnick, EW; Thareja, S | 1 |
| Wan, Y | 1 |
| Chang, TS; Chen, CL; Huang, YH; Kuo, LM; Kuo, YC; Lee, KF; Lin, SE; Lin, SY; Liu, JJ; Tsai, YH; Tung, SY; Wu, YC | 1 |
| Arun, S; Ravisankar, S; Vanisree, AJ | 1 |
| Adachi, Y; Arimura, Y; Carbone, DP; Imai, K; Koide, H; Matsunaga, Y; Motoya, M; Nosho, K; Sasaki, S; Sasaki, Y; Shinomura, Y; Takagi, H; Tokino, T; Yamamoto, H | 1 |
| Andor, G; Bergqvist, M; Bondarenko, I; Grechanaya, E; Harmenberg, J; Holgersson, G; Jerling, M; Klockare, M; Maximovich, A; Thureson, M | 1 |
| Zhao, B; Zheng, Z | 1 |
| Bujak, J; Kopytko, P; Pawlik, A; Tarnowski, M; Tkacz, M; Zgutka, K | 1 |
| Aïd, S; Bartfai, T; Cintron-Colon, R; Conti, B; François, JC; Gonzalez-Rivera, R; Holzenberger, M; Lien, T; Mori, S; Nguyen, W; Sanchez-Alavez, M | 1 |
| Anderton, H; Brameld, JM; Mohammed, RH; Sweetman, D | 1 |
| Chang, MS; Jeon, HJ; Park, J; Shin, JH | 1 |
| Chalasani, A; Kraniak, JM; Mattingly, RR; Wallace, MR | 1 |
| Huang, H; Jin, K; Mu, J; Pu, J; Ruan, L; Tan, S; Wang, F; Yang, G; Zhong, A | 1 |
| Deng, S; Jing, X; Qin, Q; She, Q; Wu, L; Yan, Y | 1 |
| Cao, F; Feng, B; Li, H; Lu, J; Tang, J; Tang, Z; Wang, H; Zhang, H; Zhang, Y | 1 |
| Dhurandhar, NV; Feizy, Z; Hegde, V; Peddibhotla, S; Shastri, AA | 1 |
| Dong, L; Du, M; Lv, Q | 1 |
| Ayloo, B; Ge, S; Gupta, S; Prasad, P; Shen, J; Wang, D; Wang, X; Wu, S; Xia, J; Xiong, Q | 1 |
| Benham, V; Bernard, JJ; Bernard, MP; Bullard, B; Dexheimer, TS; Liby, KT; Neubig, RR | 1 |
| Chen, N; Fang, X; Li, Y; Wang, J; Wang, X; Xu, H; Yang, J; Zhang, Y; Zhou, X | 1 |
| Chang, C; Guo, J; He, Q; Li, X; Shi, W; Xu, F; Zhang, Z; Zhao, S; Zheng, Q | 1 |
| Chae, JI; Cho, SS; Kwak, AW; Lee, MH; Shim, JH; Yoon, G | 1 |
| Chen, L; Du, J; Jiang, J; Liu, X; Mo, L; Peng, W; Tan, C; Zhou, W; Zhou, X | 1 |
| Fei, J; Gong, P; Xiao, C; Yang, M; Zhou, X | 1 |
| Chang, YC; Chen, ST; Hsu, MC; Li, YR; Lin, YA | 1 |
| Kepp, O; Kroemer, G; Tian, AL; Wu, Q | 1 |
| Chae, JI; Cho, SS; Joo, SH; Kwak, AW; Lee, MH; Lee, SO; Seo, JH; Shim, JH; Yoon, G | 1 |
| Chen, X; Chen, Y; Liao, F; Liu, M; Wang, W; Wen, J; Wu, Q; Xu, D | 1 |
| Athapaththu, AMGK; Choi, YH; Jayasooriya, RGPT; Jeon, YJ; Kim, GY; Lee, BJ; Molagoda, IMN; Park, JH | 1 |
| Chen, X; Lei, D; Li, D; Li, M; Lin, H; Lin, K; Wang, G; Zheng, Q; Zhu, X | 1 |
| Chen, H; Cheng, L; Hu, G; Hu, J; Jian, Q; Jin, Q; Lv, K; Shen, N; Shu, Y; Sun, X; Wu, J; Zhang, F; Zhang, J; Zhang, L | 1 |
5 review(s) available for podophyllotoxin and picropodophyllin
| Article | Year |
|---|---|
Antiviral activity of lignans.
Topics: Animals; Antiviral Agents; Humans; Lignans; Plants, Medicinal; Viruses | 1998 |
Control of apoptosis in human multiple myeloma by insulin-like growth factor I (IGF-I).
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dexamethasone; Drug Delivery Systems; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; Mice; Mice, Inbred BALB C; Mice, SCID; Models, Molecular; Multiple Myeloma; Neoplasm Proteins; Podophyllotoxin; Protein Conformation; Receptor, IGF Type 1; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Signal Transduction; Sirolimus | 2007 |
Oral therapy for nonmelanoma skin cancer in patients with advanced disease and large tumor burden: a review of the literature with focus on a new generation of targeted therapies.
Topics: Administration, Oral; Anilides; Antineoplastic Agents; Biphenyl Compounds; Capecitabine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; ErbB Receptors; Erlotinib Hydrochloride; Fluorouracil; Gefitinib; Hedgehog Proteins; Molecular Targeted Therapy; Phthalazines; Podophyllotoxin; Pyridines; Quinazolines; Receptor, IGF Type 1; Retinoids; Skin Neoplasms; Tumor Burden | 2016 |
New Mechanism of Bone Cancer Pain: Tumor Tissue-Derived Endogenous Formaldehyde Induced Bone Cancer Pain via TRPV1 Activation.
Topics: Animals; Bone Neoplasms; Cancer Pain; Capsaicin; Cells, Cultured; Formaldehyde; Glycine Hydroxymethyltransferase; Histone Demethylases; Humans; Insulin-Like Growth Factor I; Mammary Neoplasms, Experimental; Neoplasm Proteins; Osteoblasts; Peripheral Nerves; Podophyllotoxin; Protein Kinase Inhibitors; Signal Transduction; TRPV Cation Channels | 2016 |
Autophagy induction by IGF1R inhibition with picropodophyllin and linsitinib.
Topics: Animals; Autophagy; Cell Proliferation; Humans; Imidazoles; Podophyllotoxin; Protein Kinase Inhibitors; Pyrazines; Receptor, IGF Type 1 | 2021 |
3 trial(s) available for podophyllotoxin and picropodophyllin
| Article | Year |
|---|---|
A phase I pilot study of the insulin-like growth factor 1 receptor pathway modulator AXL1717 in combination with gemcitabine HCl and carboplatin in previously untreated, locally advanced, or metastatic non-small cell lung cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cohort Studies; Deoxycytidine; Female; Follow-Up Studies; Gemcitabine; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Pilot Projects; Podophyllotoxin; Prognosis; Receptor, IGF Type 1; Tissue Distribution | 2015 |
A novel oral insulin-like growth factor-1 receptor pathway modulator and its implications for patients with non-small cell lung carcinoma: A phase I clinical trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Female; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Molecular Targeted Therapy; Neutropenia; Podophyllotoxin; Prospective Studies; Receptor, IGF Type 1; Signal Transduction; Treatment Outcome | 2016 |
Phase II randomized study of the IGF-1R pathway modulator AXL1717 compared to docetaxel in patients with previously treated, locally advanced or metastatic non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Disease Progression; Docetaxel; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Podophyllotoxin; Receptor, IGF Type 1; Receptors, Somatomedin; Signal Transduction; Survival Analysis; Taxoids; Treatment Outcome | 2017 |
111 other study(ies) available for podophyllotoxin and picropodophyllin
| Article | Year |
|---|---|
Conformational analysis of podophyllotoxin and its congeners. Structure--activity relationship in microtubule assembly.
Topics: Animals; Brain; In Vitro Techniques; Magnetic Resonance Spectroscopy; Microtubules; Molecular Conformation; Podophyllotoxin; Structure-Activity Relationship | 1979 |
Methyl ethers of podophyllotoxin-related cyclolignans.
Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Mice; Podophyllotoxin; Stereoisomerism; Tumor Cells, Cultured | 1995 |
Synthesis and cytotoxicity of hydrophobic esters of podophyllotoxins.
Topics: Animals; Cell Line, Tumor; Esters; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Mice, Inbred DBA; Podophyllotoxin | 2004 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Enzyme-assisted asymmetric total synthesis of (-)-podophyllotoxin and (-)-picropodophyllin.
Topics: Enzymes; Magnetic Resonance Spectroscopy; Molecular Structure; Podophyllotoxin; Spectrometry, Mass, Fast Atom Bombardment | 2000 |
Biotransformation of podophyllotoxin to picropodophyllin by microbes.
Topics: Biotransformation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Penicillium; Podophyllotoxin | 1998 |
A concise stereocontrolled formal total synthesis of (+/-)-podophyllotoxin using sulfoxide chemistry.
Topics: Catalysis; Cyclization; Molecular Structure; Podophyllotoxin; Safrole; Stereoisomerism; Tetrahydronaphthalenes | 2004 |
The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Line; Cell Line, Tumor; Cell Survival; Fibroblasts; Humans; Insulin Receptor Substrate Proteins; Kinetics; Melanoma; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Podophyllotoxin; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Recombinant Proteins; Transfection | 2004 |
Insulin-like growth factor-I receptor activity is essential for Kaposi's sarcoma growth and survival.
Topics: Acquired Immunodeficiency Syndrome; Apoptosis; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Podophyllotoxin; Receptor, IGF Type 1; Sarcoma, Kaposi; Somatomedins; Vascular Endothelial Growth Factor A | 2005 |
Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach.
Topics: Adolescent; Adult; Cell Proliferation; Child; Craniopharyngioma; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Inhibitory Concentration 50; Insulin-Like Growth Factor I; Middle Aged; Phosphorylation; Pituitary Neoplasms; Podophyllotoxin; Receptor, IGF Type 1; Tumor Cells, Cultured | 2005 |
Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.
Topics: Animals; Bone Marrow; Cell Proliferation; Disease Models, Animal; Enzyme Activation; In Vitro Techniques; Insulin-Like Growth Factor I; Mice; Mice, Inbred C57BL; Microcirculation; Mitogen-Activated Protein Kinase 1; Multiple Myeloma; Neovascularization, Pathologic; Paraproteins; Phosphorylation; Podophyllotoxin; Receptor, IGF Type 1; Survival Rate; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2006 |
IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.
Topics: Apoptosis; CDC2 Protein Kinase; Cell Division; Cell Proliferation; Enzyme Activation; G2 Phase; Humans; Inhibitor of Apoptosis Proteins; Insulin; Insulin-Like Growth Factor I; Interleukin-6; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-bcl-2; Receptor, IGF Type 1; Receptor, Insulin; Survivin; Tumor Cells, Cultured | 2006 |
The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Multidrug Resistance-Associated Proteins; Neoplasms; Phosphorylation; Podophyllotoxin; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2006 |
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
Topics: Animals; Blotting, Western; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, SCID; Neoplasm Invasiveness; Phosphorylation; Podophyllotoxin; Receptor, IGF Type 1; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2006 |
Medicinal chemistry approaches to target the kinase activity of IGF-1R.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Benzimidazoles; Drug Evaluation, Preclinical; Humans; Neoplasms, Experimental; Podophyllotoxin; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Pyridones; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Signal Transduction; Tyrphostins | 2006 |
IGF-1R tyrosine kinase expression and dependency in clones of IGF-1R knockout cells (R-).
Topics: Animals; Cell Survival; Down-Regulation; Humans; Mice; Mice, Knockout; Podophyllotoxin; Receptor, IGF Type 1; RNA, Small Interfering; Tubulin; Tumor Cells, Cultured | 2006 |
Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I.
Topics: Basic Helix-Loop-Helix Transcription Factors; Biopsy, Needle; Cell Hypoxia; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Insulin-Like Growth Factor I; Podophyllotoxin; Reverse Transcriptase Polymerase Chain Reaction; Sarcoma, Kaposi; Signal Transduction; Structure-Activity Relationship; Time Factors; Tumor Cells, Cultured | 2006 |
Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development.
Topics: Androstadienes; Animals; Apoptosis; Cell Survival; Cells, Cultured; DNA; Flavonoids; Immunohistochemistry; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Leydig Cells; Male; Phosphorylation; Podophyllotoxin; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Testis; Wortmannin | 2007 |
In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth.
Topics: Animals; Apoptosis; Cell Line, Tumor; Down-Regulation; Female; Humans; Insulin-Like Growth Factor I; Interferon-gamma; Leukemia, T-Cell; Mice; Podophyllotoxin; Receptor, IGF Type 1; Receptors, Interferon; Sensitivity and Specificity; Signal Transduction; STAT1 Transcription Factor | 2007 |
Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor.
Topics: Animals; Cell Death; Fibroblasts; Mice; Podophyllotoxin; Receptor, IGF Type 1 | 2007 |
Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Bone Neoplasms; Disease Models, Animal; Kaplan-Meier Estimate; Mice; Multiple Myeloma; Neovascularization, Pathologic; Podophyllotoxin; Receptor, IGF Type 1 | 2007 |
The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling.
Topics: Animals; Apoptosis; Cardiovascular Agents; Carotid Artery Injuries; Catheterization; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperplasia; Insulin-Like Growth Factor I; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Signal Transduction; Time Factors; Tunica Intima | 2007 |
Rho guanosine 5'-triphosphatases differentially regulate insulin-like growth factor I (IGF-I) receptor-dependent and -independent actions of IGF-II on human trophoblast migration.
Topics: ADP Ribose Transferases; Amides; Botulinum Toxins; cdc42 GTP-Binding Protein; Cell Line; Cell Movement; Enzyme Inhibitors; Gene Silencing; Humans; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Intracellular Signaling Peptides and Proteins; Peptide Fragments; Podophyllotoxin; Protein Serine-Threonine Kinases; Pyridines; rac1 GTP-Binding Protein; Receptor, IGF Type 1; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein; Trophoblasts | 2007 |
Creatine enhances differentiation of myogenic C2C12 cells by activating both p38 and Akt/PKB pathways.
Topics: Animals; Cell Differentiation; Cell Line; Connectin; Creatine; Extracellular Signal-Regulated MAP Kinases; Glycogen Synthase Kinase 3; Imidazoles; MEF2 Transcription Factors; Mice; Models, Biological; Muscle Development; Muscle Proteins; Myoblasts; MyoD Protein; Myogenic Regulatory Factors; Myosin Heavy Chains; p38 Mitogen-Activated Protein Kinases; Phosphocreatine; Phosphorylation; Podophyllotoxin; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, IGF Type 1; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Troponin T | 2007 |
Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1.
Topics: Animals; Aorta; Apoptosis; Arrestins; beta-Arrestins; Blotting, Western; Cell Proliferation; Cells, Cultured; Down-Regulation; Flow Cytometry; Humans; Immunoprecipitation; Insulin-Like Growth Factor I; Mice; Neoplasms; Podophyllotoxin; Proto-Oncogene Proteins c-mdm2; Receptor, IGF Type 1; Receptor, Insulin; Swine; Ubiquitin | 2008 |
Silenes in organic synthesis: a concise synthesis of (+/-) -epi-picropodophyllin.
Topics: Podophyllotoxin; Silene; Stereoisomerism | 2007 |
Insulin growth factor signaling mediates neuron-like differentiation of adipose-tissue-derived stem cells.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Adult Stem Cells; Animals; Cell Differentiation; Cells, Cultured; Culture Media; Insulin-Like Growth Factor I; Neurons; Phosphorylation; Phosphotyrosine; Podophyllotoxin; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Rats; Receptor, IGF Type 1; Signal Transduction | 2008 |
Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin.
Topics: Cell Survival; Enzyme Activation; Enzyme Induction; Glioblastoma; Humans; Melanoma; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; RNA, Small Interfering; Signal Transduction; Transfection; Tumor Cells, Cultured; Ubiquitination | 2008 |
Noninvasive real-time imaging of intima thickness after rat carotid artery balloon injury using ultrasound biomicroscopy.
Topics: Animals; Carotid Arteries; Carotid Artery Injuries; Catheterization; Diagnostic Imaging; Disease Progression; Male; Microscopy, Acoustic; Observer Variation; Podophyllotoxin; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Tunica Intima; Ultrasonics | 2008 |
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Proliferation; Cell Survival; Humans; Melanoma; Mice; Mice, SCID; Neoplasm Transplantation; Podophyllotoxin; Receptor, IGF Type 1; Specific Pathogen-Free Organisms; Transplantation, Heterologous; Tumor Cells, Cultured; Uveal Neoplasms; Vascular Endothelial Growth Factor A | 2008 |
Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor.
Topics: Administration, Oral; Animals; Blotting, Western; Cell Culture Techniques; Choroid; Choroidal Neovascularization; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Injections, Intraperitoneal; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred C57BL; Pigment Epithelium of Eye; Podophyllotoxin; Receptor, IGF Type 1; Transfection; Vascular Endothelial Growth Factor A | 2008 |
Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis.
Topics: Animals; Autocrine Communication; Carcinoma, Hepatocellular; Cell Movement; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor II; Liver Neoplasms; Mice; Neoplasm Invasiveness; Neoplasm Transplantation; Podophyllotoxin; Protein Kinase Inhibitors; Receptor, IGF Type 1; Signal Transduction; Transplantation, Heterologous; Tumor Cells, Cultured; Up-Regulation | 2008 |
New picropodophyllin analogs via palladium-catalyzed allylic alkylation-Hiyama cross-coupling sequences.
Topics: Alkylation; Allyl Compounds; Benzhydryl Compounds; Catalysis; Cross-Linking Reagents; Cyclization; Ions; Ketones; Lactones; Molecular Structure; Oxidation-Reduction; Palladium; Podophyllotoxin | 2008 |
Introduction: Uveal melanoma.
Topics: Administration, Oral; Animals; Humans; Melanoma; Neoplasm Metastasis; Podophyllotoxin; Prognosis; Proto-Oncogene Proteins c-met; Receptor, IGF Type 1; Uveal Neoplasms; Vascular Endothelial Growth Factor A | 2008 |
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Extracellular Matrix Proteins; Humans; Matrix Metalloproteinase Inhibitors; Melanoma; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Phosphorylation; Podophyllotoxin; Receptor, IGF Type 1; Transplantation, Heterologous; Uveal Neoplasms | 2008 |
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Survival; Humans; Melanoma; Mice; Mice, SCID; Neoplasm Transplantation; Podophyllotoxin; Receptor, IGF Type 1; Transplantation, Heterologous; Uveal Neoplasms; Vascular Endothelial Growth Factor A | 2008 |
Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor.
Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Blotting, Western; Cell Line; Choroid; Choroidal Neovascularization; Enzyme-Linked Immunosorbent Assay; Humans; Injections, Intraperitoneal; Insulin-Like Growth Factor I; Lasers; Male; Mice; Mice, Inbred C57BL; Podophyllotoxin; Receptor, IGF Type 1; Retinal Pigment Epithelium; Vascular Endothelial Growth Factor A | 2008 |
Uveal melanoma and macular degeneration: molecular biology and potential therapeutic applications.
Topics: Animals; Biomarkers; Humans; Macular Degeneration; Melanoma; Mice; Molecular Biology; Podophyllotoxin; Prognosis; Receptor, IGF Type 1; Signal Transduction; Uveal Neoplasms; Vascular Endothelial Growth Factor A | 2008 |
Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066. Part I: process development.
Topics: Biotransformation; Podophyllotoxin; Pseudomonas aeruginosa; Species Specificity | 2009 |
Igf1r as a therapeutic target in a mouse model of basal-like breast cancer.
Topics: Animals; Breast Neoplasms; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunophenotyping; Mice; Mice, Transgenic; Models, Biological; Podophyllotoxin; ras Proteins; Receptor, IGF Type 1; Signal Transduction | 2009 |
HPLC-DAD and HPLC-ESI-MS separation, determination and identification of the spin-labeled diastereoisomers of podophyllotoxin.
Topics: Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Molecular Structure; Podophyllotoxin; Spectrometry, Mass, Electrospray Ionization; Spin Labels; Stereoisomerism; Tandem Mass Spectrometry | 2009 |
Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Osteosarcoma; Podophyllotoxin; Protein Kinase Inhibitors; Receptor, IGF Type 1; RNA, Small Interfering | 2009 |
Beta-amyloid monomers are neuroprotective.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Butadienes; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitriles; Peptide Fragments; Podophyllotoxin; Rats; Tyrphostins | 2009 |
Selective insulin-like growth factor-I antagonist inhibits mouse embryo development in a dose-dependent manner.
Topics: Animals; Embryonic Development; Insulin-Like Growth Factor I; Mice; Podophyllotoxin; Receptor, IGF Type 1; RNA, Messenger | 2010 |
Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Humans; Immunoprecipitation; Mice; Mice, SCID; Podophyllotoxin; Receptor, IGF Type 1; Xenograft Model Antitumor Assays | 2010 |
Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of beta-catenin signaling.
Topics: Animals; beta Catenin; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chondrocytes; Growth Plate; Insulin-Like Growth Factor I; Phosphatidylinositol 3-Kinases; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Signal Transduction; Triiodothyronine; Wnt Proteins; Wnt4 Protein | 2010 |
Insulin-like growth factor-I receptor in proliferation and motility of pancreatic cancer.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromones; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; Mice; Models, Biological; Morpholines; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Podophyllotoxin; Receptor, IGF Type 1; Signal Transduction; Wound Healing | 2010 |
Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma.
Topics: Apoptosis; Cell Survival; Humans; Melanoma; Podophyllotoxin; Receptor, IGF Type 1; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured | 2010 |
IGF-1 receptor inhibition by picropodophyllin in medulloblastoma.
Topics: Animals; Caspase 3; Cell Proliferation; Cerebellar Neoplasms; Disease Models, Animal; Gene Knockdown Techniques; Humans; Medulloblastoma; Mice; Podophyllotoxin; Receptor, IGF Type 1 | 2010 |
Role of the adrenergic system in a mouse model of oxygen-induced retinopathy: antiangiogenic effects of beta-adrenoreceptor blockade.
Topics: Adrenergic beta-Antagonists; Angiogenesis Inhibitors; Animals; Animals, Newborn; Blood-Retinal Barrier; Blotting, Western; Capillary Permeability; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Humans; Infant, Newborn; Injections, Intraperitoneal; Injections, Subcutaneous; Insulin-Like Growth Factor I; Intravitreal Injections; Male; Mice; Mice, Inbred C57BL; Oxygen; Podophyllotoxin; Propranolol; Receptor, IGF Type 1; Receptors, Adrenergic, beta; Retinal Neovascularization; Retinopathy of Prematurity; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A | 2011 |
Determination of picropodophyllin and its isomer podophyllotoxin in human serum samples with electrospray ionization of hexylamine adducts by liquid chromatography-tandem mass spectrometry.
Topics: Adult; Aged, 80 and over; Amines; Animals; Chromatography, Liquid; Drug Stability; Drugs, Chinese Herbal; Female; Humans; Least-Squares Analysis; Male; Mice; Podophyllotoxin; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Swine; Tandem Mass Spectrometry | 2011 |
Peripheral sensitization caused by insulin-like growth factor 1 contributes to pain hypersensitivity after tissue injury.
Topics: Animals; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Hyperalgesia; Insulin-Like Growth Factor I; Male; Oncogene Protein v-akt; Pain Measurement; Pain Threshold; Podophyllotoxin; Postoperative Complications; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, IGF Type 1; Skin | 2011 |
Expression and effects of inhibition of type I insulin-like growth factor receptor tyrosine kinase in mantle cell lymphoma.
Topics: Aged; Aged, 80 and over; Apoptosis; Cell Line, Tumor; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; K562 Cells; Lymphoma, Mantle-Cell; Male; Middle Aged; Podophyllotoxin; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Receptor, IGF Type 1; RNA, Messenger; Signal Transduction | 2011 |
Molecular characterization of acquired tolerance of tumor cells to picropodophyllin (PPP).
Topics: Allelic Imbalance; Cell Line, Tumor; Chromosome Aberrations; Cluster Analysis; Comparative Genomic Hybridization; DNA Copy Number Variations; DNA Methylation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genotype; Humans; In Situ Hybridization, Fluorescence; Metaphase; Neoplasms; Podophyllotoxin; Proto-Oncogene Proteins c-myc; Reproducibility of Results; RNA, Small Interfering; Spectral Karyotyping | 2011 |
Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: clinical implications.
Topics: Adenocarcinoma; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Survival; Colonic Neoplasms; Down-Regulation; HCT116 Cells; HT29 Cells; Humans; Phosphorylation; Podophyllotoxin; Signal Transduction; Tumor Cells, Cultured | 2012 |
18F-FDG microPET imaging detects early transient response to an IGF1R inhibitor in genetically engineered rhabdomyosarcoma models.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Fluorodeoxyglucose F18; Mice; Podophyllotoxin; Positron-Emission Tomography; Receptor, IGF Type 1; Rhabdomyosarcoma | 2012 |
Insulin-like growth factors promote vasculogenesis in embryonic stem cells.
Topics: Animals; Carrier Proteins; Cell Differentiation; Embryoid Bodies; Embryonic Stem Cells; Endothelium; Extracellular Signal-Regulated MAP Kinases; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Mesoderm; Mice; Models, Biological; Neovascularization, Physiologic; Podophyllotoxin; Protein Stability; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Receptor, IGF Type 2; Signal Transduction; Vascular Endothelial Growth Factor A | 2012 |
The HDAC inhibitor LBH589 enhances the antimyeloma effects of the IGF-1RTK inhibitor picropodophyllin.
Topics: Animals; Apoptosis; Caspase 8; Cell Adhesion; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Drug Synergism; G2 Phase Cell Cycle Checkpoints; Gene Expression Profiling; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Mice; Mice, Inbred C57BL; Multiple Myeloma; Panobinostat; Podophyllotoxin; Receptor, IGF Type 1; Transcriptome; Tumor Cells, Cultured | 2012 |
Effects of epidermal growth factor receptor and insulin-like growth factor 1 receptor inhibition on proliferation and intracellular signaling in cutaneous SCCHN: potential for dual inhibition as a therapeutic modality.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Erlotinib Hydrochloride; Fluorescent Antibody Technique; Head and Neck Neoplasms; Humans; Insulin-Like Growth Factor Binding Protein 1; Podophyllotoxin; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Squamous Cell Carcinoma of Head and Neck | 2013 |
IGF-1 alleviates ox-LDL-induced inflammation via reducing HMGB1 release in HAECs.
Topics: Aorta; Blotting, Western; Cell Line; Endothelial Cells; Gene Expression; HMGB1 Protein; Humans; Inflammation; Insulin-Like Growth Factor I; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Microscopy, Confocal; Oxidation-Reduction; Phosphorylation; Podophyllotoxin; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Time Factors | 2012 |
Investigating new therapeutic strategies targeting hyperinsulinemia's mitogenic effects in a female mouse breast cancer model.
Topics: Animals; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Female; Growth Substances; Hyperinsulinism; Insulin; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Molecular Targeted Therapy; Peptides; Podophyllotoxin; Receptor, IGF Type 1; Therapies, Investigational | 2013 |
Epigenetic modification after inhibition of IGF-1R signaling in human central nervous system atypical teratoid rhabdoid tumor (AT/RT).
Topics: Acetylation; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Epigenesis, Genetic; Epigenomics; Histone Acetyltransferases; Histone Deacetylases; Histones; Humans; Methylation; Podophyllotoxin; Receptor, IGF Type 1; Rhabdoid Tumor; Signal Transduction; Teratoma; Tumor Cells, Cultured | 2013 |
The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; Mice; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Signal Transduction; Xenograft Model Antitumor Assays | 2013 |
Picropodophyllin inhibits epithelial ovarian cancer cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Female; Growth Inhibitors; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Podophyllotoxin; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2013 |
Alternative cytotoxic effects of the postulated IGF-IR inhibitor picropodophyllin in vitro.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Dose-Response Relationship, Drug; ErbB Receptors; Esophageal Neoplasms; Humans; Microtubules; Phosphorylation; Podophyllotoxin; Protein Kinase Inhibitors; Receptor, IGF Type 1; Signal Transduction; Tubulin Modulators | 2013 |
Abnormal expression of insulin-like growth factor-I receptor in hepatoma tissue and its inhibition to promote apoptosis of tumor cells.
Topics: Adult; Aged; Apoptosis; Base Sequence; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Male; Middle Aged; Molecular Sequence Data; Podophyllotoxin; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2013 |
Hospicells promote upregulation of the ATP-binding cassette genes by insulin-like growth factor-I via the JAK2/STAT3 signaling pathway in an ovarian cancer cell line.
Topics: ATP-Binding Cassette Transporters; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; Janus Kinase 2; Ovarian Neoplasms; Podophyllotoxin; Receptor, IGF Type 1; Signal Transduction; STAT3 Transcription Factor; Stromal Cells; Tumor Microenvironment | 2013 |
Picropodophyllin inhibits tumor growth of human nasopharyngeal carcinoma in a mouse model.
Topics: Animals; Antineoplastic Agents; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Mice, Nude; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Somatomedins; Xenograft Model Antitumor Assays | 2013 |
[Effects of inhibited IGF-IR expression on proliferation and apoptosis of human hepatocellular carcinoma cell lines].
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; Podophyllotoxin; Receptor, IGF Type 1 | 2013 |
The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin.
Topics: Animals; Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Humans; Mice; Mutation; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Tumor Burden; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2013 |
Inhibition of type I insulin-like growth factor receptor tyrosine kinase by picropodophyllin induces apoptosis and cell cycle arrest in T lymphoblastic leukemia/lymphoma.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Phosphorylation; Podophyllotoxin; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Proteomics; Receptor, IGF Type 1; Signal Transduction | 2014 |
The insulin-like growth factor-I receptor inhibitor picropodophyllin-induced selective apoptosis of hepatocellular carcinoma cell through a caspase-dependent mitochondrial pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; Liver Neoplasms; Mitochondria, Liver; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptor, IGF Type 1 | 2013 |
Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.
Topics: Cell Line, Tumor; Cell Proliferation; Hodgkin Disease; Humans; Podophyllotoxin; Prognosis; Receptor, IGF Type 1; Survival Analysis; Tumor Microenvironment | 2014 |
The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomimetic Materials; Biphenyl Compounds; Cell Line, Tumor; Drug Synergism; Humans; Mice; Mice, Inbred C57BL; Multiple Myeloma; Nitrophenols; Piperazines; Podophyllotoxin; Receptor, IGF Type 1; Sulfonamides | 2014 |
Star-shaped polycaprolactone-polyethyleneglycol copolymer micelle-like nanoparticles for picropodophyllin delivery.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Humans; Micelles; Nanoparticles; Particle Size; Podophyllotoxin; Polyesters; Polyethylene Glycols | 2014 |
A subset of bone marrow stromal cells regulate ATP-binding cassette gene expression via insulin-like growth factor-I in a leukemia cell line.
Topics: ATP-Binding Cassette Transporters; Cell Line, Tumor; Cell Proliferation; Daunorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Insulin-Like Growth Factor I; Leukemia; Mesenchymal Stem Cells; Podophyllotoxin; Receptor, IGF Type 1; Receptors, Somatomedin | 2014 |
IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cisplatin; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Molecular Targeted Therapy; Neoplasm Staging; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Paclitaxel; Podophyllotoxin; Proteasome Endopeptidase Complex; Receptor, IGF Type 1 | 2014 |
Targeting the insulin-like growth factor-1 receptor by picropodophyllin for lung cancer chemoprevention.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Humans; Lung Neoplasms; Mice; Podophyllotoxin; Receptor, IGF Type 1 | 2015 |
Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via insulin-like growth factor-1 receptor-independent mechanism.
Topics: Animals; Antineoplastic Agents; Apoptosis; CDC2 Protein Kinase; Cell Survival; Centrosome; Cyclin B1; Cyclin-Dependent Kinases; Enzyme Activation; G2 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; Lung Neoplasms; MCF-7 Cells; Microtubules; Mitosis; Podophyllotoxin; Receptor, IGF Type 1; Receptors, Somatomedin; RNA Interference; Signal Transduction; Time Factors; Transfection; Tubulin; Xenograft Model Antitumor Assays | 2014 |
IGF-1R signaling is essential for the proliferation of cultured mouse spermatogonial stem cells by promoting the G2/M progression of the cell cycle.
Topics: Animals; Cell Proliferation; Cells, Cultured; Fibroblast Growth Factor 2; G2 Phase Cell Cycle Checkpoints; Glial Cell Line-Derived Neurotrophic Factor; M Phase Cell Cycle Checkpoints; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Signal Transduction; Spermatogonia | 2015 |
Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Caspase 3; Cell Survival; Cells, Cultured; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin-Like Growth Factor I; Myeloid Cell Leukemia Sequence 1 Protein; Neuroprotective Agents; Oxygen; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Somatomedin; Reperfusion Injury; Signal Transduction; Sitosterols | 2015 |
Picropodophyllin inhibits proliferation and survival of diffuse large B-cell lymphoma cells.
Topics: Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Lymphoma, Large B-Cell, Diffuse; MAP Kinase Signaling System; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Signal Transduction | 2015 |
Duodenal Expression of 25 Hydroxyvitamin D3-1α-hydroxylase Is Higher in Adolescents Than in Children and Adults.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Adolescent; Adult; Age Factors; Aged; Animals; Child; Child, Preschool; Duodenum; Female; Humans; Insulin-Like Growth Factor I; Male; Mice; Middle Aged; Podophyllotoxin; Receptor, IGF Type 1; Sexual Maturation; Young Adult | 2015 |
Picropodophyllin inhibits the growth of Ewing's sarcoma cells through the insulin‑like growth factor‑1 receptor/Akt signaling pathway.
Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Sarcoma, Ewing; Signal Transduction | 2015 |
Inflammation Promotes Expression of Stemness-Related Properties in HBV-Related Hepatocellular Carcinoma.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cell Survival; Chemokine CCL2; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; Homeodomain Proteins; Humans; Inflammation; Insulin-Like Growth Factor I; Liver Neoplasms; Nanog Homeobox Protein; Neoplastic Stem Cells; Octamer Transcription Factor-3; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Signal Transduction; Spheroids, Cellular; Tumor Cells, Cultured | 2016 |
Connexin 30 downregulates Insulin-like growth factor receptor-1, abolishes Erk and potentiates effects of an IGF-R inhibitor in a glioma cell line.
Topics: Animals; Cell Enlargement; Cell Line, Tumor; Cell Movement; Cell Survival; Connexin 30; Connexins; Down-Regulation; Glioma; MAP Kinase Signaling System; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Rats; Receptor, IGF Type 1; RNA, Messenger | 2016 |
The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gastrointestinal Neoplasms; Gastrointestinal Tract; Genes, ras; Humans; Mice; Molecular Targeted Therapy; Mutation; Neoplasm Invasiveness; Podophyllotoxin; Proto-Oncogene Proteins p21(ras); Receptor, IGF Type 1; Signal Transduction; Up-Regulation | 2017 |
Insulin Growth Factor 1 Protects Neural Stem Cells Against Apoptosis Induced by Hypoxia Through Akt/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase (Akt/MAPK/ERK) Pathway in Hypoxia-Ishchemic Encephalopathy.
Topics: Animals; Apoptosis; Cell Cycle; Cell Hypoxia; Cell Proliferation; Cell Survival; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Hypoxia-Ischemia, Brain; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Neural Stem Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Podophyllotoxin; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2017 |
Picropodophyllin (PPP) is a potent rhabdomyosarcoma growth inhibitor both in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemotaxis; Disease Models, Animal; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression; Humans; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Ligands; Male; Mice; Podophyllotoxin; Receptor, IGF Type 1; Receptor, Insulin; Rhabdomyosarcoma; Signal Transduction; Xenograft Model Antitumor Assays | 2017 |
Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction.
Topics: Aging; Animals; Caloric Restriction; Energy Metabolism; Female; Gene Dosage; Homeostasis; Hypothermia; Longevity; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Podophyllotoxin; Receptor, IGF Type 1; Sex Characteristics; Signal Transduction | 2017 |
Effects of insulin like growth factors on early embryonic chick limb myogenesis.
Topics: Animals; Butadienes; Chick Embryo; Chromones; Enzyme Inhibitors; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; Hindlimb; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Morpholines; Muscle Development; Muscle, Skeletal; MyoD Protein; Myogenin; Nitriles; PAX3 Transcription Factor; Phosphoinositide-3 Kinase Inhibitors; Podophyllotoxin; Pyrroles; Receptor, IGF Type 1; Receptors, Vascular Endothelial Growth Factor | 2017 |
Insulin-like growth factor binding protein-6 released from human mesenchymal stem cells confers neuronal protection through IGF-1R-mediated signaling.
Topics: Culture Media, Conditioned; Gene Expression; Humans; Hydrogen Peroxide; Insulin-Like Growth Factor Binding Protein 6; Insulin-Like Growth Factor II; Lysophosphatidylcholines; Mesenchymal Stem Cells; Neurons; Neuroprotection; Organ Culture Techniques; Podophyllotoxin; Primary Cell Culture; Receptor, IGF Type 1; Signal Transduction; Spinal Cord | 2017 |
Development of 3D culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening.
Topics: Antineoplastic Agents; Benzimidazoles; Bone Morphogenetic Protein 2; Cell Culture Techniques; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Genes, Neurofibromatosis 1; Genes, Reporter; Humans; Luminescent Proteins; MAP Kinase Kinase 1; Molecular Targeted Therapy; Neurofibroma, Plexiform; Neurofibromatosis 1; Phenotype; Podophyllotoxin; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Receptor, IGF Type 1; Red Fluorescent Protein; Schwann Cells; Transduction, Genetic; Tumor Cells, Cultured | 2018 |
Metformin suppresses growth and adrenocorticotrophic hormone secretion in mouse pituitary corticotroph tumor AtT20 cells.
Topics: Adenylate Kinase; Adrenocorticotropic Hormone; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Corticotrophs; Humans; Metformin; Pituitary Neoplasms; Podophyllotoxin; Receptor, IGF Type 1; Signal Transduction | 2018 |
Insulin-like growth factor 1 receptor signaling regulates embryonic epicardial cell proliferation through focal adhesion kinase pathway.
Topics: Animals; Cell Proliferation; Cells, Cultured; Focal Adhesion Kinase 1; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Mice, Inbred C57BL; Pericardium; Podophyllotoxin; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Signal Transduction | 2018 |
Protection of insulin‑like growth factor 1 on experimental peripheral neuropathy in diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred NOD; Myelin Sheath; Neural Conduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Podophyllotoxin; Recombinant Proteins; Sciatic Nerve | 2018 |
E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling.
Topics: 3T3-L1 Cells; Adenoviruses, Human; Animals; Diabetes Mellitus, Type 2; Glucose; Glucose Transporter Type 4; Insulin; Mice; Models, Biological; Peptides; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Signal Transduction; Viral Proteins; Wortmannin | 2018 |
Picropodophyllin inhibits type I endometrial cancer cell proliferation via disruption of the PI3K/Akt pathway.
Topics: Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Phosphatidylinositol 3-Kinases; Phosphorylation; Podophyllotoxin; Prognosis; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Signal Transduction; Survivin | 2019 |
Neurovascular Coupling in the Dentate Gyrus Regulates Adult Hippocampal Neurogenesis.
Topics: Animals; Blood Flow Velocity; Dentate Gyrus; Enzyme Inhibitors; Exploratory Behavior; Hippocampus; Hyperemia; Insulin-Like Growth Factor I; Interneurons; Mice; Microcirculation; Neurogenesis; Neurovascular Coupling; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Parvalbumins; Podophyllotoxin; Receptor, IGF Type 1; Signal Transduction | 2019 |
Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay.
Topics: Animals; Antineoplastic Agents; Cell Culture Techniques; Cell Proliferation; Cell Transformation, Neoplastic; Drug Screening Assays, Antitumor; Fibroblast Growth Factor 2; Fibroblasts; Fluvastatin; High-Throughput Screening Assays; Humans; Mice; Models, Biological; Neoplasms; Obesity; Podophyllotoxin; Skin | 2019 |
Regulation of Hippo-YAP signaling by insulin-like growth factor-1 receptor in the tumorigenesis of diffuse large B-cell lymphoma.
Topics: Adaptor Proteins, Signal Transducing; Aged; Animals; Apoptosis; B-Lymphocytes; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Transformation, Neoplastic; CRISPR-Cas Systems; Female; Gene Expression Regulation, Neoplastic; Hippo Signaling Pathway; Humans; Insulin-Like Growth Factor I; Lymphoma, Large B-Cell, Diffuse; Male; Mice; Mice, SCID; Middle Aged; Neoplasm Proteins; Podophyllotoxin; Protein Serine-Threonine Kinases; Pseudolymphoma; Random Allocation; Receptor, IGF Type 1; RNA Interference; RNA, Small Interfering; Signal Transduction; Transcription Factors; Tyrphostins; Verteporfin; Xenograft Model Antitumor Assays; YAP-Signaling Proteins | 2020 |
IGF‑IR promotes clonal cell proliferation in myelodysplastic syndromes via inhibition of the MAPK pathway.
Topics: Adolescent; Adult; Aged; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Computational Biology; Female; Gene Knockdown Techniques; Humans; K562 Cells; Male; MAP Kinase Signaling System; Middle Aged; Myelodysplastic Syndromes; Podophyllotoxin; Receptor, IGF Type 1; Transcriptome | 2020 |
Picropodophyllotoxin, an Epimer of Podophyllotoxin, Causes Apoptosis of Human Esophageal Squamous Cell Carcinoma Cells Through ROS-Mediated JNK/P38 MAPK Pathways.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Stress; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Isomerism; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinase 8; p38 Mitogen-Activated Protein Kinases; Podophyllotoxin; Reactive Oxygen Species; Signal Transduction | 2020 |
Zinc-α2-glycoprotein relieved seizure-Induced neuronal glucose uptake impairment via insulin-like growth factor 1 receptor-regulated glucose transporter 3 expression.
Topics: Adipokines; Animals; Anticonvulsants; Female; Gene Expression Regulation; Glucose; Glucose Transporter Type 3; Magnesium Deficiency; Neurons; Podophyllotoxin; Pregnancy; Primary Cell Culture; Rats; Receptor, IGF Type 1; Seizures | 2021 |
Inhibition of SNCG suppresses the proliferation of lung cancer cells induced by high glucose.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; gamma-Synuclein; Gene Knockdown Techniques; Glucose; Humans; Inflammation; Insulin-Like Growth Factor I; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Proteins; Podophyllotoxin; Receptor, IGF Type 1; Tumor Necrosis Factor-alpha; Tumor Stem Cell Assay | 2021 |
Activation of IGF-1 pathway and suppression of atrophy related genes are involved in Epimedium extract (icariin) promoted C2C12 myotube hypertrophy.
Topics: Animals; Cell Differentiation; Cell Line; Chromones; Flavonoids; Gene Expression Regulation; Hypertrophy; Insulin-Like Growth Factor I; Mice; Morpholines; Myoblasts; Myosin Heavy Chains; Podophyllotoxin; Signal Transduction; Sirolimus | 2021 |
Picropodophyllotoxin Induces G1 Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer Cells via ROS Generation and Activation of p38 MAPK Signaling Pathway.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Survival; Colorectal Neoplasms; Endoplasmic Reticulum Stress; HCT116 Cells; Humans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; p38 Mitogen-Activated Protein Kinases; Podophyllotoxin; Reactive Oxygen Species | 2021 |
Selective elimination of CML stem/progenitor cells by picropodophyllin in vitro and in vivo is associated with p53 activation.
Topics: Animals; Antigens, CD34; Apoptosis; Disease Models, Animal; Fetal Blood; Fusion Proteins, bcr-abl; Humans; In Vitro Techniques; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Transgenic; Microtubules; Neoplastic Stem Cells; Phosphorylation; Podophyllotoxin; Signal Transduction; Stem Cells; Transcriptional Activation; Tumor Suppressor Protein p53 | 2021 |
Gamma-Aminobutyric Acid (GABA) Promotes Growth in Zebrafish Larvae by Inducing IGF-1 Expression via GABA
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gene Expression Profiling; Gene Expression Regulation, Developmental; Glycerophosphates; Larva; Mice; Podophyllotoxin; Receptor, IGF Type 1; Receptors, GABA; Receptors, Somatotropin; Somatomedins; Zebrafish; Zebrafish Proteins | 2021 |
Picropodophyllin Inhibits the Proliferation of Human Prostate Cancer DU145 and LNCaP Cells via ROS Production and PI3K/AKT Pathway Inhibition.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Male; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Podophyllotoxin; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species | 2022 |
Repurposing picropodophyllin as a potential thyroid eye disease treatment via delaying mitotic clonal expansion through a patient-derived preclinical platform.
Topics: Adipocytes; Graves Ophthalmopathy; Humans; Podophyllotoxin | 2023 |