Page last updated: 2024-08-21

podophyllotoxin and paclitaxel

podophyllotoxin has been researched along with paclitaxel in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (18.29)	18.7374
1990's	13 (15.85)	18.2507
2000's	17 (20.73)	29.6817
2010's	34 (41.46)	24.3611
2020's	3 (3.66)	2.80

Authors

Authors	Studies
Burger, AM; Camacho Gomez, JA; Düssmann, H; Günther, EG; Hirano, T; Ishii, Y; Prehn, JH; Prinz, H; Schmidt, P; Stoiber, T; Umezawa, K; Unger, E	1
Fang, X; Shao, L; Wang, S; Zhang, H	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Prinz, H; Schmidt, P; Unger, E; Zuse, A	2
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Cafici, L; Canonico, PL; Galli, U; Genazzani, AA; Imperio, D; Pagliai, F; Pirali, T; Sorba, G; Tron, GC	1
Antipin, MY; Dhawan, AS; Elias, EM; Evdokimov, NM; Knee, EJ; Kornienko, A; Magedov, IV; Manpadi, M; Ogasawara, MA; Rogelj, S; Steelant, WF; Tongwa, P; Uglinskii, PY; Van Slambrouck, S	1
Chanotiya, CS; Darokar, MP; Faridi, U; Khanuja, SP; Krishna, V; Kumar, JK; Luqman, S; Negi, AS; Saxena, HO; Srivastava, S	1
Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Prinz, H; Schmidt, P; Unger, E	2
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Nickel, HC; Prinz, H; Schmidt, P; Unger, E	1
Aicher, B; Amon, P; Böhm, KJ; Chamasmani, B; Gerlach, M; Günther, EG; Ivanov, I; Müller, K; Prinz, H; Vogel, K	1
Bhoga, Ud; Evdokimov, NM; Fernandes, MA; Frolova, L; George, O; Georgiou, KH; Getlik, M; Kinnibrugh, TL; Kornienko, A; Magedov, IV; Manpadi, M; Renner, S; Rogelj, S; Shuster, CB; Steelant, WF; Tang, H; van Otterlo, WA; Van slambrouck, S	1
Chanda, D; Chanotiya, CS; Gupta, A; Kaur, T; Khan, F; Luqman, S; Negi, AS; Prakasham, AP; Saxena, AK; Shanker, K; Yadav, DK	1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P	1
Akula, B; Bharathi, EV; Billa, VK; Cosenza, SC; Gallo, JM; Lv, H; Mallireddigari, MR; Padgaonkar, A; Pallela, VR; Reddy, EP; Reddy, MV; Subbaiah, DR	1
Chanda, D; Hasanain, M; Khan, F; Konwar, R; Kumar, A; Luqman, S; Masood, N; Mitra, K; Negi, AS; Pal, A; Sarkar, J; Sathish Kumar, B; Singh, A; Singh, J; Yadav, DK	1
Ganga Reddy, V; Jain, N; Kamal, A; Paidakula, S; Polepalli, S; Shankaraiah, N; Srinivasa Reddy, T; Srinivasulu, V	1
Borrelli, S; Cappelletti, G; Cartelli, D; Christodoulou, MS; Damia, G; Dosio, F; Ficarra, I; Passarella, D; Ricci, F; Silvani, A; Zucchetti, M	1
Alam, S; Amtul, Z; Arigari, NK; Balasubramanian, S; Dubey, V; Jonnala, KK; Khan, F; Ponnam, D; Shilpi, S; Siddiqui, L; Srinivas, KV; Suiab, L; Tiwari, AK	1
Aksenov, AV; Aksenov, NA; Aksenova, IV; Brenner, AJ; Bryan, BA; Cavazos, DA; Correa, J; De Carvalho, A; Frolova, LV; Johnston, RK; Kiss, R; Kornienko, A; Lefranc, F; Magedov, IV; Mathieu, V; Nguyen, G; Pendleton, AL; Reisenauer, MR; Rogelj, S; Rubin, M; Smirnov, AN	1
Hyder, I; Ismail, T; Kalivendi, SV; Khazir, J; Miryala, S; Nalla, N; Sampath Kumar, HM; Yedlapudi, D	1
Brett, ML; Colley, HE; Coole, SF; Danson, SJ; Dossetter, AG; Griffen, EJ; Harrison, J; Jackson, LV; Jennings, LR; Lockey, PM; Mason, DP; Muthana, M; Norman, D; Thompson, MJ; Tulasi, V; Williams, L; Wong, M	1
Bahulayan, AK; Kabeer, FA; Madhusoodhanan, AR; Nair, MS; Prakasan, N; Prathapan, R; Rajalekshmi, DS; Varughese, S	1
Aksenov, AV; Brenner, AJ; Cavazos, DA; Cencic, R; Dasari, R; Evidente, A; Frolova, LV; Henry, S; Kidner, R; Kiss, R; Kornienko, A; Lefranc, F; Ma, X; Magedov, IV; Mathieu, V; Pelletier, J; Pertsemlidis, A; Reisenauer, MR; Rogelj, S; Yu, X	1
Han, HW; Hu, C; Lu, GH; Qi, JL; Qiu, HY; Sun, WX; Wang, XM; Yang, RW; Yang, YH	1
Han, HW; Ji, YJ; Lin, HY; Lu, GH; Qi, JL; Sun, WX; Wan, Y; Wang, XM; Yang, YH	1
Awale, S; Bringmann, G; Bruhn, T; Brun, R; Feineis, D; Kaiser, M; Li, J; Mudogo, V; Seupel, R	1
Liu, Y; Xu, Z; Zhao, SJ	1
Chen, TT; Kong, LY; Leng, JF; Yan, XY; Yin, Y; Zhao, YJ	1
Kolonias, D; Lampidis, TJ; Rubin, RW; Savaraj, N	1
Baas, PW; Black, MM; Humphries, S	1
Menon, KM; Rajan, VP	1
Matsumoto, G; Murofushi, H; Sakai, H	1
Avila, J; Serrano, L; Villanueva, N; Wandosell, F	1
Yalowich, JC	1
Aletta, JM; Greene, LA	1
Black, MM	1
Brady, ST; Sahenk, Z	1
Carney, DH; Crossin, KL	1
Kumar, N	1
Horwitz, SB; Parness, J	1
Horwitz, SB; Manfredi, JJ; Parness, J; Schiff, PB	1
Fujii, T; Kondo, Y; Kumasaka, M; Ohki, K; Suzuki, T	1
Christen, P; Jaussi, R; Skoda, RC	1
Ichikawa, M; Matsumoto, G; Murofushi, H; Sakai, H; Tasaki, A	1
Allam, N; Breillout, F; Debal, V; Gourdier, B; Manfait, M; Millot, JM; Morjani, H	1
Knipling, L; Wolff, J	1
Lu, Q; Luduena, RF	1
Landberg, G; Norberg, B; Rantapää Dahlqvist, S; Roos, G	1
Cordell, GA; Kingston, DG; Neidigh, KA; Pengsuparp, T; Pezzuto, JM	1
Knipling, L; Sackett, DL; Wolff, J	1
Day, BW; Hamel, E; Rosenkranz, HS; ter Haar, E	1
Caron, JM	1
Crosignani, A; D'Incalci, M; Donelli, MG; Munzone, E; Zucchetti, M	1
Basu, A; Haldar, S	1
Jordan, MA; Wilson, L	1
Hagen, K; Kong, AN; Mandlekar, S; Roninson, IB; Shtil, AA; Tan, TH; Walter, RJ; Yu, R	1
Bastow, KF; Chen, K; Lee, FY; Lee, KH; Shi, Q; Tachibana, Y; Wang, HK	1
Markman, M; Zanotti, KM	1
Bunn, PA; Simon, GR	1
Gupta, MM; Khanuja, SP; Kumar, JK; Negi, AS; Srivastava, V	1
Bane, S; Ganesh, T; Kingston, DG; Sharma, S	1
Ahn, S; Dalton, JT; Li, CM; Lu, Y; Miller, DD; Narayanan, R	1
Mou, Y; Shan, T; Zhao, J; Zhou, L	1
Chandra, S	1
Akhmanova, A; Doodhi, H; Kapitein, LC; Katrukha, EA; Meijering, E; Mohan, R; Smal, I; Steinmetz, MO	1
Chen, M; Duan, H; Jiang, Z; Miao, J; Sun, L; Wang, Y; Wu, M; Zhang, L; Zhang, S; Zhang, X; Zhu, X	1
Araujo, DP; da Silva Neto, L; da Silva, CM; da Silva, DL; de Fátima, A; Nascimento de Aquino, RA; Terra, BS	1
Chaudhury, S; Gaikwad, SM; Jinager, A; Maheshwari, A; Ray, P; Singh, RK	1
Epifano, F	1
Aiba, N; Itoh, G; Iwabuchi, Y; Kohyama, A; Kuriyama, S; Shibata, H; Tanaka, M; Yashiro, M	1
Nandagopal, K; Routh, S	1
Cai, Q; Chen, Q; Hao, H; Wang, G; Wu, B; Zang, X; Zhang, J; Zheng, X; Zhou, F; Zhu, X	1
Cao, H; Cui, X; Guo, H; Han, C; Li, Y; Wang, S; Xi, X; Xu, F; Zheng, M	1
Bian, W; Chen, M; He, P; Li, Y; Lu, X; Ren, X; Vasilatos, SN; Yao, B; Yao, C; Zhang, X	1
Babu, S; Biankin, AV; Chang, DK; Escobar-Hoyos, LF; K Bai, JD; Kawalerski, RR; Leiton, CV; Otsuka, Y; Pan, CH; Scampavia, L; Shroyer, KR; Spicer, T; Sridharan, B; Torrente Gonçalves, M; Woo, M	1
Goyal, S; Gupta, A; Gupta, M; Jaremko, M; Meshram, V; Qureshi, KA; Shukla, KK	1

Reviews

11 review(s) available for podophyllotoxin and paclitaxel

Article	Year
1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. European journal of medicinal chemistry, 2019, Dec-01, Volume: 183 Topics: Antineoplastic Agents; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Triazoles	2019
Role of microtubules and axolinin in membrane excitation of the squid giant axon. Advances in biophysics, 1985, Volume: 19 Topics: Alkaloids; Animals; Axons; Calcium; Cell Membrane; Colchicine; Cyclic AMP; Cytoskeleton; Decapodiformes; Intracellular Fluid; Membrane Potentials; Microtubule-Associated Proteins; Microtubules; Nerve Tissue Proteins; Paclitaxel; Peptide Synthases; Podophyllotoxin; Sodium; Sulfhydryl Reagents; Tubulin	1985
Pharmacokinetics of anticancer agents in patients with impaired liver function. European journal of cancer (Oxford, England : 1990), 1998, Volume: 34, Issue:1 Topics: Anthracyclines; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Humans; Liver Diseases; Paclitaxel; Podophyllotoxin; Vinca Alkaloids	1998
Prevention and management of antineoplastic-induced hypersensitivity reactions. Drug safety, 2001, Volume: 24, Issue:10 Topics: Antineoplastic Agents; Asparaginase; Docetaxel; Drug Hypersensitivity; Humans; Neoplasms; Organoplatinum Compounds; Paclitaxel; Podophyllotoxin; Taxoids	2001
Taxanes in the treatment of advanced (stage III and IV) non-small cell lung cancer (NSCLC): recent developments. Cancer investigation, 2003, Volume: 21, Issue:1 Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Docetaxel; Etoposide; Female; Gemcitabine; Humans; Lung Neoplasms; Male; Microtubules; Multicenter Studies as Topic; Neoadjuvant Therapy; Organoplatinum Compounds; Paclitaxel; Palliative Care; Podophyllotoxin; Randomized Controlled Trials as Topic; Salvage Therapy; Survival Analysis; Taxoids; Teniposide; Treatment Outcome; Vinblastine; Vinorelbine	2003
Plant-based anticancer molecules: a chemical and biological profile of some important leads. Bioorganic & medicinal chemistry, 2005, Nov-01, Volume: 13, Issue:21 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Humans; Paclitaxel; Podophyllotoxin; Stilbenes	2005
Endophytic fungi: novel sources of anticancer lead molecules. Applied microbiology and biotechnology, 2012, Volume: 95, Issue:1 Topics: Antineoplastic Agents; Camptothecin; Endophytes; Fungi; Paclitaxel; Podophyllotoxin; Symbiosis; Vinca Alkaloids	2012
From nature to market: examples of natural products that became drugs. Recent patents on biotechnology, 2014, Volume: 8, Issue:1 Topics: Biological Products; Galantamine; Morphine; Paclitaxel; Pharmaceutical Preparations; Podophyllotoxin	2014
Patent Survey of Resveratrol, Taxol, Podophyllotoxin, Withanolides and Their Derivatives Used in Anticancer Therapy. Recent patents on biotechnology, 2017, Volume: 11, Issue:2 Topics: Humans; Neoplasms; Paclitaxel; Patents as Topic; Podophyllotoxin; Resveratrol; Stilbenes; Withanolides	2017
Yield enhancement strategies of rare pharmaceutical metabolites from endophytes. Biotechnology letters, 2018, Volume: 40, Issue:5 Topics: Anthracenes; DNA Shuffling; Endophytes; Fermentation; Industrial Microbiology; Limonins; Metabolome; Paclitaxel; Perylene; Plants; Podophyllotoxin	2018
Fungal Endophytes: Microfactories of Novel Bioactive Compounds with Therapeutic Interventions; A Comprehensive Review on the Biotechnological Developments in the Field of Fungal Endophytic Biology over the Last Decade. Biomolecules, 2023, 06-25, Volume: 13, Issue:7 Topics: Biology; Endophytes; Fungi; Paclitaxel; Podophyllotoxin	2023

Trials

1 trial(s) available for podophyllotoxin and paclitaxel

Article	Year
CPH 82. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 2003, Volume: 17, Issue:5 Topics: Administration, Oral; Arthritis, Rheumatoid; Clinical Trials as Topic; Glycosides; Humans; Lignans; Paclitaxel; Podophyllotoxin	2003

Other Studies

70 other study(ies) available for podophyllotoxin and paclitaxel

Article	Year
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 2003, Jul-17, Volume: 46, Issue:15 Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Biopolymers; Blotting, Western; Cell Cycle; Cell Survival; Drug Screening Assays, Antitumor; Humans; K562 Cells; Microscopy, Electron; Structure-Activity Relationship; Tubulin	2003
CHMIS-C: a comprehensive herbal medicine information system for cancer. Journal of medicinal chemistry, 2005, Mar-10, Volume: 48, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Databases, Factual; Internet; National Institutes of Health (U.S.); Neoplasms; Phytotherapy; Plant Preparations; United States; United States Food and Drug Administration	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 2006, Dec-28, Volume: 49, Issue:26 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Proliferation; Cell Survival; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Flow Cytometry; Humans; Inhibitory Concentration 50; K562 Cells; Leukemia P388; Mice; Molecular Structure; Structure-Activity Relationship; Thiophenes; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	2006
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry. Bioorganic & medicinal chemistry, 2007, Nov-01, Volume: 15, Issue:21 Topics: 4-Butyrolactone; Antineoplastic Agents; Catalysis; Cell Line, Tumor; Humans; Lactones; Lignans; Molecular Conformation; Podophyllotoxin; Ruthenium; Triazoles; Tubulin	2007
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 2007, Nov-29, Volume: 50, Issue:24 Topics: Anthracenes; Cell Cycle; Cell Line, Tumor; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Naphthalenes; Nocodazole; Podophyllotoxin; Structure-Activity Relationship; Thiophenes; Tubulin; Tubulin Modulators	2007
Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones. Journal of medicinal chemistry, 2008, Apr-24, Volume: 51, Issue:8 Topics: Antineoplastic Agents; Biological Products; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Pyridones; Quinolones; Spectrometry, Mass, Electrospray Ionization; Tubulin	2008
Gallic acid-based indanone derivatives as anticancer agents. Bioorganic & medicinal chemistry letters, 2008, Jul-15, Volume: 18, Issue:14 Topics: Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; Erythrocytes; Gallic Acid; Hemolysis; Humans; Indans; Inhibitory Concentration 50; Models, Chemical; Osmosis; Tetrazolium Salts; Thiazoles	2008
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5 Topics: Anthracenes; Binding, Competitive; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase; Humans; Protein Binding; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2009
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety. European journal of medicinal chemistry, 2010, Volume: 45, Issue:8 Topics: Anthracenes; Antineoplastic Agents; Benzylidene Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Protein Multimerization; Protein Structure, Quaternary; Tubulin	2010
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 2011, Jun-23, Volume: 54, Issue:12 Topics: Antineoplastic Agents; Biopolymers; Cell Cycle; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Organ Specificity; Oxazines; Phenothiazines; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2011
Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis. Journal of medicinal chemistry, 2011, Jun-23, Volume: 54, Issue:12 Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Computer Simulation; HeLa Cells; Heterocyclic Compounds; Humans; Indoles; Models, Molecular; Molecular Mimicry; Naphthalenes; Podophyllotoxin; Pyrazoles; Pyridines; Small Molecule Libraries; Stereoisomerism; Tubulin Modulators	2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization. Bioorganic & medicinal chemistry, 2011, Jul-15, Volume: 19, Issue:14 Topics: Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Microtubules; Molecular Structure; Schiff Bases; Stereoisomerism; Structure-Activity Relationship; Tubulin	2011
Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization. Bioorganic & medicinal chemistry, 2012, May-01, Volume: 20, Issue:9 Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzodioxoles; Benzylidene Compounds; Binding Sites; Cell Line, Tumor; Cell Proliferation; Computer Simulation; Humans; Indans; Mice; Protein Structure, Tertiary; Tubulin; Tubulin Modulators	2012
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22 Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship	2012
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents. Journal of medicinal chemistry, 2013, Jul-11, Volume: 56, Issue:13 Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Blood-Brain Barrier; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Drug Design; Drug Resistance, Neoplasm; HCT116 Cells; Humans; K562 Cells; MCF-7 Cells; Mice; Mice, Nude; Microtubules; Neoplasms; Polymerization; Sulfonamides; Tubulin; Tumor Burden; Xenograft Model Antitumor Assays	2013
Synthesis of neolignans as microtubule stabilisers. Bioorganic & medicinal chemistry, 2014, Feb-15, Volume: 22, Issue:4 Topics: Administration, Oral; Animals; Antineoplastic Agents; Binding Sites; Body Weight; Cell Line, Tumor; Coumaric Acids; Female; G2 Phase Cell Cycle Checkpoints; Half-Life; Humans; Lignans; M Phase Cell Cycle Checkpoints; Male; MCF-7 Cells; Mice; Molecular Docking Simulation; Protein Stability; Protein Structure, Tertiary; Tubulin	2014
Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors. Bioorganic & medicinal chemistry letters, 2014, Aug-01, Volume: 24, Issue:15 Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Heterocyclic Compounds, 4 or More Rings; Humans; MCF-7 Cells; Molecular Structure; Phenanthrolines; Polymerization; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2014
New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A. European journal of medicinal chemistry, 2014, Oct-06, Volume: 85 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Drug Carriers; Drug Liberation; Epothilones; Humans; MCF-7 Cells; Microtubules; Nanostructures; Paclitaxel; Podophyllotoxin; Squalene	2014
Synthesis of cyclic 1,9-acetal derivatives of forskolin and their bioactivity evaluation. European journal of medicinal chemistry, 2014, Nov-24, Volume: 87 Topics: Acetals; Animals; Cell Line; Cell Line, Tumor; Colforsin; Crystallography, X-Ray; Drug Evaluation, Preclinical; Humans; Magnetic Resonance Spectroscopy; MCF-7 Cells; Models, Molecular; Rats; Spectrometry, Mass, Electrospray Ionization	2014
Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells. Journal of medicinal chemistry, 2015, Mar-12, Volume: 58, Issue:5 Topics: Antineoplastic Agents; Cell Differentiation; Cells, Cultured; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fibroblasts; Humans; Hydroxamic Acids; Indoles; Neoplasms; Neoplastic Stem Cells; Structure-Activity Relationship	2015
Synthesis and Biological evaluation of novel 4β-[(5-substituted)-1,2,3,4-tetrazolyl] podophyllotoxins as anticancer compounds. Bioorganic & medicinal chemistry letters, 2015, Jul-15, Volume: 25, Issue:14 Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; HeLa Cells; Humans; Podophyllotoxin; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2015
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer. Journal of medicinal chemistry, 2015, Dec-10, Volume: 58, Issue:23 Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Cell Proliferation; Drug Screening Assays, Antitumor; Head and Neck Neoplasms; Heterografts; Humans; Indoles; Male; Mice; Mice, Nude; Microtubules; Neoplasm Transplantation; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2015
Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives. Bioorganic & medicinal chemistry letters, 2016, Apr-01, Volume: 26, Issue:7 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Humans; Lignans; Models, Molecular; Neoplasms; Piper; Seeds	2016
5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells. European journal of medicinal chemistry, 2016, Sep-14, Volume: 120 Topics: Amaryllidaceae; Amaryllidaceae Alkaloids; Antineoplastic Agents; Drug Resistance, Neoplasm; Humans; Plant Extracts; Tumor Cells, Cultured	2016
Design, synthesis and anti-cancer activity evaluation of podophyllotoxin-norcantharidin hybrid drugs. Bioorganic & medicinal chemistry letters, 2016, 07-15, Volume: 26, Issue:14 Topics: Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; MCF-7 Cells; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship	2016
Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents. Bioorganic & medicinal chemistry letters, 2017, 09-01, Volume: 27, Issue:17 Topics: Acetates; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Esters; Humans; MCF-7 Cells; Molecular Structure; Piperazine; Piperazines; Podophyllotoxin; Polymerization; Structure-Activity Relationship; Tubulin	2017
Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line. Journal of natural products, 2017, 10-27, Volume: 80, Issue:10 Topics: Algorithms; Alkaloids; Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Congo; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Isoquinolines; Leishmania donovani; Magnoliopsida; Molecular Structure; Naphthalenes; Nuclear Magnetic Resonance, Biomolecular; Pancreatic Neoplasms; Plasmodium falciparum; Rats; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Tumor Cells, Cultured	2017
Design, synthesis, and biological evaluation of novel diphenylamine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Colchicine; Diphenylamine; Drug Screening Assays, Antitumor; Humans; Mice; Molecular Docking Simulation; Poly(ADP-ribose) Polymerase Inhibitors; Polymerization; Tubulin; Tubulin Modulators	2022
Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents. Proceedings of the National Academy of Sciences of the United States of America, 1992, Feb-15, Volume: 89, Issue:4 Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Doxorubicin; Etoposide; Heart Rate; In Vitro Techniques; Microtubules; Myocardial Contraction; Nocodazole; Paclitaxel; Podophyllotoxin; Rats; Tubulin; Vinca Alkaloids	1992
Dynamics of alpha-tubulin deacetylation in intact neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1989, Volume: 9, Issue:1 Topics: Acetates; Acetylation; Alkaloids; Animals; Azides; Cytoskeleton; Isomerism; Microtubules; Neurons; Paclitaxel; Podophyllotoxin; Polymers; Tubulin	1989
Involvement of microtubules in lipoprotein degradation and utilization for steroidogenesis in cultured rat luteal cells. Endocrinology, 1985, Volume: 117, Issue:6 Topics: Alkaloids; Animals; Benzimidazoles; Cells, Cultured; Colchicine; Corpus Luteum; Deuterium; Dimethyl Sulfoxide; Female; Humans; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lumicolchicines; Microtubules; Nocodazole; Paclitaxel; Podophyllotoxin; Progesterone; Rats; Time Factors; Vinblastine	1985
Analysis of drug-tubulin interaction by trypsin cleavage: comparison for colchicine, podophyllotoxin, griseofulvin, vinblastine and taxol. Comparative biochemistry and physiology. B, Comparative biochemistry, 1986, Volume: 85, Issue:3 Topics: Alkaloids; Animals; Brain; Colchicine; Griseofulvin; Paclitaxel; Podophyllotoxin; Protein Binding; Swine; Trypsin; Tubulin; Vinblastine	1986
Effects of microtubule inhibitors on etoposide accumulation and DNA damage in human K562 cells in vitro. Cancer research, 1987, Feb-15, Volume: 47, Issue:4 Topics: Alkaloids; Cell Line; Colchicine; DNA; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Humans; In Vitro Techniques; Maytansine; Microtubules; Paclitaxel; Podophyllotoxin; Time Factors; Vinblastine	1987
Sequential phosphorylation of chartin microtubule-associated proteins is regulated by the presence of microtubules. The Journal of cell biology, 1987, Volume: 105, Issue:1 Topics: Alkaloids; Animals; Benzimidazoles; Cell Line; Microtubule-Associated Proteins; Microtubules; Nerve Growth Factors; Neurons; Nocodazole; Paclitaxel; Pheochromocytoma; Phosphorylation; Podophyllotoxin; Protein Kinases; Protein Processing, Post-Translational; Rats	1987
Taxol interferes with the interaction of microtubule-associated proteins with microtubules in cultured neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1987, Volume: 7, Issue:11 Topics: Alkaloids; Animals; Cells, Cultured; Dimethyl Sulfoxide; Methionine; Microtubule-Associated Proteins; Microtubules; Molecular Weight; Neurons; Paclitaxel; Podophyllotoxin; Rats	1987
Axonal tubulin and microtubules: morphologic evidence for stable regions on axonal microtubules. Cell motility and the cytoskeleton, 1987, Volume: 8, Issue:2 Topics: Alkaloids; Animals; Axons; Microscopy, Electron; Microtubules; Optic Nerve; Paclitaxel; Podophyllotoxin; Rats; Rats, Inbred Strains; Triflupromazine; Tubulin	1987
Evidence that microtubule depolymerization early in the cell cycle is sufficient to initiate DNA synthesis. Cell, 1981, Volume: 23, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cells, Cultured; Colchicine; DNA Replication; Growth Substances; Microtubules; Paclitaxel; Podophyllotoxin; Terpenes; Thrombin; Vinblastine	1981
Taxol-induced polymerization of purified tubulin. Mechanism of action. The Journal of biological chemistry, 1981, Oct-25, Volume: 256, Issue:20 Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Binding, Competitive; Brain; Cattle; Kinetics; Macromolecular Substances; Microtubules; Paclitaxel; Podophyllotoxin; Protein Binding; Tubulin	1981
Taxol binds to polymerized tubulin in vitro. The Journal of cell biology, 1981, Volume: 91, Issue:2 Pt 1 Topics: Actins; Alkaloids; Animals; Binding, Competitive; Calcium Chloride; Cattle; Microtubules; Paclitaxel; Podophyllotoxin; Polymers; Tubulin; Vinblastine	1981
Taxol: a new probe for studying the structure and function of microtubules. Cold Spring Harbor symposia on quantitative biology, 1982, Volume: 46 Pt 1 Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Binding Sites; Brain; Calcium; Cattle; Kinetics; Microscopy, Electron; Microtubule-Associated Proteins; Microtubules; Nerve Tissue Proteins; Paclitaxel; Podophyllotoxin; Proteins; Vinblastine	1982
Stimulation of tubulin-dependent ATPase activity in microtubule proteins from porcine brain by taxol. Journal of neurochemistry, 1983, Volume: 41, Issue:3 Topics: Adenosine Triphosphatases; Alkaloids; Animals; Brain; Ca(2+) Mg(2+)-ATPase; Calcium; Colchicine; Microtubule-Associated Proteins; Paclitaxel; Podophyllotoxin; Proteins; Swine; Tubulin; Vinblastine	1983
Vinblastine inhibits the maturation of the precursor of mitochondrial aspartate aminotransferase. Vincristine and six other cytoskeleton inhibitors do not show this effect. Biochemical and biophysical research communications, 1983, Aug-30, Volume: 115, Issue:1 Topics: Alkaloids; Animals; Aspartate Aminotransferases; Benzimidazoles; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Chick Embryo; Colchicine; Cytochalasin D; Cytochalasins; Enzyme Precursors; Fibroblasts; Kinetics; Mitochondria; Nocodazole; Oxygen Consumption; Paclitaxel; Phalloidine; Podophyllotoxin; Vinblastine	1983
Axonal microtubules necessary for generation of sodium current in squid giant axons: I. Pharmacological study on sodium current and restoration of sodium current by microtubule proteins and 260K protein. The Journal of membrane biology, 1984, Volume: 77, Issue:2 Topics: Alkaloids; Animals; Axons; Colchicine; Decapodiformes; Deuterium; Deuterium Oxide; Dimethyl Sulfoxide; Dithionitrobenzoic Acid; Ethylmaleimide; Microtubules; Paclitaxel; Podophyllotoxin; Sodium; Temperature; Tubulin; Vinblastine; Water	1984
[Characterization of the mechanism of cross-resistance to vinca alkaloids and taxoids in the human J82 bladder tumor cell line]. Bulletin du cancer, 1994, Volume: 81, Issue:10 Topics: Antineoplastic Agents; Carcinoma; Colchicine; Doxorubicin; Drug Resistance, Multiple; Gene Expression Regulation, Neoplastic; Humans; Paclitaxel; Phenotype; Podophyllotoxin; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Vinblastine; Vinorelbine	1994
Antimicrotubule properties of benzophenanthridine alkaloids. Biochemistry, 1993, Dec-07, Volume: 32, Issue:48 Topics: Alkaloids; Animals; Benzophenanthridines; Berberine Alkaloids; Colchicine; Isoquinolines; Microtubules; Paclitaxel; Phenanthridines; Podophyllotoxin; Protein Binding; Rats; Spectrometry, Fluorescence; Tetrahydroisoquinolines; Tubulin	1993
Removal of beta III isotype enhances taxol induced microtubule assembly. Cell structure and function, 1993, Volume: 18, Issue:3 Topics: Animals; Brain; Cattle; Colchicine; Cold Temperature; In Vitro Techniques; Microscopy, Electron; Microtubules; Paclitaxel; Podophyllotoxin; Tubulin	1993
Cell cycle effects of the anti-rheumatic agent CPH82. British journal of rheumatology, 1994, Volume: 33, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Cycle; Cell Line; DNA; Glycosides; Humans; Lignans; Nuclear Proteins; Paclitaxel; Podophyllotoxin; Proliferating Cell Nuclear Antigen	1994
Evaluation of the cytotoxic mechanism mediated by baccatin III, the synthetic precursor of taxol. Chemico-biological interactions, 1996, Aug-14, Volume: 101, Issue:2 Topics: Alkaloids; Animals; Antineoplastic Agents; Binding Sites; Cell Cycle; Colchicine; Humans; Mice; Microtubules; Paclitaxel; Podophyllotoxin; Polymers; Protein Binding; Taxoids; Tubulin; Tumor Cells, Cultured; Vinblastine	1996
Cation selective promotion of tubulin polymerization by alkali metal chlorides. Protein science : a publication of the Protein Society, 1996, Volume: 5, Issue:10 Topics: Animals; Biopolymers; Cations; Cesium; Chlorides; Dimethyl Sulfoxide; Guanidine; Guanidines; Lithium Chloride; Microtubule-Associated Proteins; Microtubules; Paclitaxel; Peptide Fragments; Podophyllotoxin; Potassium Chloride; Rats; Sodium Chloride; Static Electricity; Tubulin	1996
Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents. Bioorganic & medicinal chemistry, 1996, Volume: 4, Issue:10 Topics: Antineoplastic Agents, Phytogenic; Bibenzyls; Binding Sites; Colchicine; Models, Molecular; Paclitaxel; Podophyllotoxin; Protein Conformation; Software; Stilbenes; Tubulin; Tubulin Modulators	1996
Posttranslational modification of tubulin by palmitoylation: I. In vivo and cell-free studies. Molecular biology of the cell, 1997, Volume: 8, Issue:4 Topics: Animals; Blood Platelets; Brain Chemistry; Cell Membrane; Cell-Free System; Demecolcine; Guanosine Triphosphate; Humans; Male; Microtubules; Nocodazole; Paclitaxel; Palmitoyl Coenzyme A; Podophyllotoxin; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Substrate Specificity; Swine; Thrombin; Tubulin; Vinblastine	1997
Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein. International journal of oncology, 1998, Volume: 13, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Benzoquinones; Binding Sites; Colchicine; Demecolcine; Enzyme Inhibitors; Gout Suppressants; Humans; Lactams, Macrocyclic; Microtubules; Mutagenesis, Site-Directed; Paclitaxel; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-raf; Quinones; Serine; Tumor Cells, Cultured	1998
Use of drugs to study role of microtubule assembly dynamics in living cells. Methods in enzymology, 1998, Volume: 298 Topics: Alkaloids; Antineoplastic Agents; Biopolymers; Cell Line; Colchicine; Drug Synergism; Microtubules; Molecular Weight; Nocodazole; Paclitaxel; Podophyllotoxin; Tubulin; Vinblastine	1998
Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells. Oncogene, 1999, Jan-14, Volume: 18, Issue:2 Topics: Apoptosis; Breast Neoplasms; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Colchicine; Egtazic Acid; Enzyme Activation; Humans; Microtubules; Nocodazole; Paclitaxel; Podophyllotoxin; Tumor Cells, Cultured; Vincristine	1999
Antitumor agents 210. Synthesis and evaluation of taxoid-epipodophyllotoxin conjugates as novel cytotoxic agents. Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:11 Topics: Antineoplastic Agents; Cell Division; Cross-Linking Reagents; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Paclitaxel; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured	2001
Promotion of tubulin assembly by poorly soluble taxol analogs. Analytical biochemistry, 2007, Jan-01, Volume: 360, Issue:1 Topics: Biopolymers; Chromatography, High Pressure Liquid; Dimethyl Sulfoxide; Guanosine Diphosphate; Guanosine Triphosphate; Microscopy, Electron; Paclitaxel; Podophyllotoxin; Solubility; Tubulin	2007
Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin. Journal of mass spectrometry : JMS, 2010, Volume: 45, Issue:10 Topics: Animals; Binding Sites; Binding, Competitive; Cattle; Chromatography, Liquid; Colchicine; Docetaxel; Guanosine Triphosphate; Linear Models; Paclitaxel; Podophyllotoxin; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Taxoids; Thiazoles; Tubulin; Tubulin Modulators; Vinblastine; Vincristine	2010
Plant-derived bioactive compounds produced by endophytic fungi. Mini reviews in medicinal chemistry, 2011, Volume: 11, Issue:2 Topics: Biological Products; Camptothecin; Fungi; Paclitaxel; Plants; Podophyllotoxin; Symbiosis	2011
End-binding proteins sensitize microtubules to the action of microtubule-targeting agents. Proceedings of the National Academy of Sciences of the United States of America, 2013, May-28, Volume: 110, Issue:22 Topics: Bridged Bicyclo Compounds, Heterocyclic; Cellular Senescence; Colchicine; Depsipeptides; Green Fluorescent Proteins; HeLa Cells; Humans; Lactones; Microscopy, Fluorescence; Microtubule-Associated Proteins; Microtubules; Models, Biological; Paclitaxel; Podophyllotoxin; Statistics, Nonparametric; Stilbenes; Tubulin Modulators; Vinblastine	2013
Deoxypodophyllotoxin exerts both anti-angiogenic and vascular disrupting effects. The international journal of biochemistry & cell biology, 2013, Volume: 45, Issue:8 Topics: Amides; Angiogenesis Inhibitors; Animals; Blood Vessels; Cell Cycle; Cell Movement; Cell Proliferation; Chickens; Chorioallantoic Membrane; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Drugs, Chinese Herbal; Human Umbilical Vein Endothelial Cells; Humans; In Vitro Techniques; Male; Mice, Nude; Microtubules; Neovascularization, Pathologic; Neovascularization, Physiologic; Paclitaxel; Podophyllotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Xenograft Model Antitumor Assays	2013
IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells. Cancer letters, 2014, Nov-28, Volume: 354, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cisplatin; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Molecular Targeted Therapy; Neoplasm Staging; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Paclitaxel; Podophyllotoxin; Proteasome Endopeptidase Complex; Receptor, IGF Type 1	2014
Novel Anticancer Drugs from Nature. Current medicinal chemistry, 2015, Volume: 22, Issue:30 Topics: Antineoplastic Agents, Phytogenic; Biological Products; Camptothecin; Humans; Paclitaxel; Podophyllotoxin; Vinca Alkaloids	2015
Identification of anti-cancer chemical compounds using Xenopus embryos. Cancer science, 2016, Volume: 107, Issue:6 Topics: Animals; Antineoplastic Agents; Benzodioxoles; Benzofurans; Carbolines; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Evaluation, Preclinical; Embryo Loss; Embryo, Nonmammalian; Female; Gastrulation; Glioma; Indole Alkaloids; Melanoma, Experimental; Mice; Microtubules; Neoplasm Invasiveness; Paclitaxel; Podophyllotoxin; Rats; Receptors, CXCR4; Xenograft Model Antitumor Assays; Xenopus	2016
A Promising Microtubule Inhibitor Deoxypodophyllotoxin Exhibits Better Efficacy to Multidrug-Resistant Breast Cancer than Paclitaxel via Avoiding Efflux Transport. Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:5 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Female; G2 Phase Cell Cycle Checkpoints; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubules; Neoplasm Proteins; Paclitaxel; Podophyllotoxin	2018
Transferrin receptor-targeted redox/pH-sensitive podophyllotoxin prodrug micelles for multidrug-resistant breast cancer therapy. Journal of materials chemistry. B, 2019, 10-14, Volume: 7, Issue:38 Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Survival; Disulfides; Drug Resistance, Multiple; Female; Glutathione; Humans; Hydrogen-Ion Concentration; MCF-7 Cells; Mice; Micelles; Nanoparticles; Oxidation-Reduction; Paclitaxel; Podophyllotoxin; Polyethylene Glycols; Prodrugs; Receptors, Transferrin	2019
An unbiased high-throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer. Molecular oncology, 2020, Volume: 14, Issue:8 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fluorouracil; Gemcitabine; High-Throughput Screening Assays; Humans; Keratin-17; Mice, Inbred C57BL; Microtubules; Paclitaxel; Pancreatic Neoplasms; Podophyllotoxin; Tumor Burden	2020