podophyllotoxin has been researched along with nocodazole in 43 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 12 (27.91) | 18.7374 |
1990's | 10 (23.26) | 18.2507 |
2000's | 8 (18.60) | 29.6817 |
2010's | 13 (30.23) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Burger, AM; Camacho Gomez, JA; Düssmann, H; Günther, EG; Hirano, T; Ishii, Y; Prehn, JH; Prinz, H; Schmidt, P; Stoiber, T; Umezawa, K; Unger, E | 1 |
Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Prinz, H; Schmidt, P; Unger, E; Zuse, A | 2 |
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Prinz, H; Schmidt, P; Unger, E | 2 |
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
Chernyshova, NB; Ikizalp, NN; Kiselyov, AS; Kislyi, KA; Kuznetsov, SA; Lantow, M; Leitao, A; Lemcke, H; Oprea, T; Raihstat, MM; Samet, AV; Semenov, VV; Semenova, MN; Weiss, DG | 1 |
Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Nickel, HC; Prinz, H; Schmidt, P; Unger, E | 1 |
Böhm, KJ; Müller, K; Prinz, H; Surkau, G | 1 |
Aicher, B; Amon, P; Böhm, KJ; Chamasmani, B; Gerlach, M; Günther, EG; Ivanov, I; Müller, K; Prinz, H; Vogel, K | 1 |
Firgang, SI; Fuchs, F; Kiselyov, AS; Konyushkin, LD; Kuznetsov, SA; Lantow, M; Malyshev, OR; Philchenkov, AA; Raihstat, MM; Semenov, RV; Semenov, VV; Semenova, MN; Stielow, A; Tsyganov, DV; Zavelevich, MP; Zefirov, NS | 1 |
Akula, B; Bharathi, EV; Billa, VK; Cosenza, SC; Gallo, JM; Lv, H; Mallireddigari, MR; Padgaonkar, A; Pallela, VR; Reddy, EP; Reddy, MV; Subbaiah, DR | 1 |
Camarasa, MJ; Canela, MD; Díaz, JF; Liekens, S; Noppen, S; Pérez-Pérez, MJ; Priego, EM; Sáez-Calvo, G | 1 |
Jain, N; Kamal, A; Polepalli, S; Reddy, VG; Shalini, N; Shankaraiah, N; Srinivasa Reddy, T; Subba Rao, AV | 1 |
Aghaee, E; Böhm, KJ; Ghasemi, JB; Ivanov, I; Müller, K; Prinz, H; Ridder, AK; Vogel, K | 1 |
Briguglio, I; Carta, A; Corona, P; Fermeglia, M; Laurini, E; Piras, S; Pirisi, MA; Pricl, S | 1 |
He, L; Tang, YJ; Xiang, TL; Zhao, W | 1 |
Liu, Y; Xu, Z; Zhao, SJ | 1 |
Kolonias, D; Lampidis, TJ; Rubin, RW; Savaraj, N | 1 |
Jordan, MA; Thrower, D; Wilson, L | 1 |
Dye, RB; Flicker, PF; Lien, DY; Williams, RC | 1 |
Austin, RC; Dudani, AK; Gupta, RS; Venner, TJ | 1 |
Menon, KM; Rajan, VP | 1 |
Aletta, JM; Greene, LA | 1 |
Gupta, RS | 3 |
Bane, S; Ludueña, RF; Roach, MC | 1 |
Langford, GM; Luduena, RF; MacRae, TH; Roach, MC | 1 |
Hamel, E; Lin, CM | 1 |
Christen, P; Jaussi, R; Skoda, RC | 1 |
Ludueña, RF; Roach, MC | 1 |
Chalfie, M; Thomson, JN | 1 |
Schrek, R; Stefani, SS | 1 |
Northover, AM; Northover, BJ | 1 |
Ackerman-Morris, S; Bollenbacher, WE; Smith, WA; Watson, CJ; Watson, RD | 1 |
Caron, JM | 1 |
Jordan, MA; Wilson, L | 1 |
Chaudhuri, AR; Curcio, M; Ludueña, RF; Mizuhashi, F; Murata, K; Prasad, V; Tomita, I | 1 |
Hagen, K; Kong, AN; Mandlekar, S; Roninson, IB; Shtil, AA; Tan, TH; Walter, RJ; Yu, R | 1 |
Atomi, Y; Fujita, Y; Katayama, E; Ohto, E | 1 |
Burnett, JC; Day, BW; Gussio, R; Hamel, E; Hermone, AR; McGrath, C; Nguyen, TL; Wipf, P; Zaharevitz, DW | 1 |
1 review(s) available for podophyllotoxin and nocodazole
Article | Year |
---|---|
1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.
Topics: Antineoplastic Agents; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Triazoles | 2019 |
42 other study(ies) available for podophyllotoxin and nocodazole
Article | Year |
---|---|
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Biopolymers; Blotting, Western; Cell Cycle; Cell Survival; Drug Screening Assays, Antitumor; Humans; K562 Cells; Microscopy, Electron; Structure-Activity Relationship; Tubulin | 2003 |
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Proliferation; Cell Survival; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Flow Cytometry; Humans; Inhibitory Concentration 50; K562 Cells; Leukemia P388; Mice; Molecular Structure; Structure-Activity Relationship; Thiophenes; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 2006 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Topics: Anthracenes; Cell Cycle; Cell Line, Tumor; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Naphthalenes; Nocodazole; Podophyllotoxin; Structure-Activity Relationship; Thiophenes; Tubulin; Tubulin Modulators | 2007 |
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Topics: Anthracenes; Binding, Competitive; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase; Humans; Protein Binding; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2009 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.
Topics: Animals; Antineoplastic Agents; Biological Assay; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Microtubules; Mitosis; Models, Molecular; Molecular Structure; Oxadiazoles; Phenotype; Sea Urchins; Structure-Activity Relationship; Tumor Cells, Cultured | 2010 |
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
Topics: Anthracenes; Antineoplastic Agents; Benzylidene Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Protein Multimerization; Protein Structure, Quaternary; Tubulin | 2010 |
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives.
Topics: Anthracenes; Antineoplastic Agents; Cell Proliferation; Humans; Inhibitory Concentration 50; K562 Cells; Oximes; Protein Multimerization; Protein Structure, Quaternary; Tubulin | 2010 |
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Topics: Antineoplastic Agents; Biopolymers; Cell Cycle; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Organ Specificity; Oxazines; Phenothiazines; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2011 |
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Topics: Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Microtubules; Molecular Structure; Schiff Bases; Stereoisomerism; Structure-Activity Relationship; Tubulin | 2011 |
Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays.
Topics: Animals; Antimitotic Agents; Apoptosis; Aza Compounds; Caspase 2; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Embryo, Nonmammalian; Humans; Microtubules; Petroselinum; Plant Extracts; Plant Oils; Podophyllotoxin; Sea Urchins; Seeds; Stereoisomerism; Structure-Activity Relationship; Tubulin Modulators | 2011 |
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Blood-Brain Barrier; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Drug Design; Drug Resistance, Neoplasm; HCT116 Cells; Humans; K562 Cells; MCF-7 Cells; Mice; Mice, Nude; Microtubules; Neoplasms; Polymerization; Sulfonamides; Tubulin; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach.
Topics: Antineoplastic Agents; Binding Sites; Cell Cycle; Cell Proliferation; Cells, Cultured; Colchicine; Cyclohexanones; Drug Evaluation, Preclinical; Drug Stability; Humans; Neoplasm Invasiveness; Spindle Apparatus; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2014 |
Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2014 |
N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization.
Topics: Alkylating Agents; Antineoplastic Agents; Ethylenediamines; G2 Phase Cell Cycle Checkpoints; Humans; K562 Cells; Molecular Docking Simulation; Oxazines; Phenothiazines; Piperazines; Polymerization; Quantitative Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2017 |
Triazolopyridinyl-acrylonitrile derivatives as antimicrotubule agents: Synthesis, in vitro and in silico characterization of antiproliferative activity, inhibition of tubulin polymerization and binding thermodynamics.
Topics: Acrylonitrile; Antineoplastic Agents; Binding Sites; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Polymerization; Pyridines; Structure-Activity Relationship; Thermodynamics; Triazoles; Tubulin; Tubulin Modulators | 2017 |
Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain.
Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Cycle Checkpoints; Colchicine; Drug Design; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; Podophyllotoxin; Tubulin; Tubulin Modulators | 2019 |
Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Doxorubicin; Etoposide; Heart Rate; In Vitro Techniques; Microtubules; Myocardial Contraction; Nocodazole; Paclitaxel; Podophyllotoxin; Rats; Tubulin; Vinca Alkaloids | 1992 |
Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis.
Topics: Cell Cycle; Centromere; Chromosomes; Dose-Response Relationship, Drug; HeLa Cells; Humans; Metaphase; Microtubules; Mitosis; Nocodazole; Podophyllotoxin; Spindle Apparatus; Vinblastine | 1992 |
End-stabilized microtubules observed in vitro: stability, subunit, interchange, and breakage.
Topics: Alkaloids; Animals; Arsenicals; Brain Chemistry; Cattle; Griseofulvin; Male; Microscopy, Electron; Microscopy, Interference; Microtubules; Nocodazole; Podophyllotoxin; Sea Urchins; Sperm Tail; Tubulin; Tubulin Modulators; Video Recording | 1992 |
Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria.
Topics: Animals; Antineoplastic Agents; Cell Line; Chick Embryo; Colchicine; Fluorescent Antibody Technique; Guinea Pigs; Microtubules; Mitochondria; Mutation; Nocodazole; Podophyllotoxin; Vinblastine | 1990 |
Involvement of microtubules in lipoprotein degradation and utilization for steroidogenesis in cultured rat luteal cells.
Topics: Alkaloids; Animals; Benzimidazoles; Cells, Cultured; Colchicine; Corpus Luteum; Deuterium; Dimethyl Sulfoxide; Female; Humans; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lumicolchicines; Microtubules; Nocodazole; Paclitaxel; Podophyllotoxin; Progesterone; Rats; Time Factors; Vinblastine | 1985 |
Sequential phosphorylation of chartin microtubule-associated proteins is regulated by the presence of microtubules.
Topics: Alkaloids; Animals; Benzimidazoles; Cell Line; Microtubule-Associated Proteins; Microtubules; Nerve Growth Factors; Neurons; Nocodazole; Paclitaxel; Pheochromocytoma; Phosphorylation; Podophyllotoxin; Protein Kinases; Protein Processing, Post-Translational; Rats | 1987 |
Cross-resistance of nocodazole-resistant mutants of CHO cells toward other microtubule inhibitors: similar mode of action of benzimidazole carbamate derivatives and NSC 181928 and TN-16.
Topics: Animals; Benzimidazoles; Carbamates; Cell Line; Cricetinae; Drug Resistance; Female; Microtubules; Mutation; Nocodazole; Ovary; Podophyllotoxin; Pyrazines; Pyrrolidinones | 1986 |
Species-specific differences in toxicity of antimitotic agents toward cultured mammalian cells.
Topics: 4-Butyrolactone; Animals; Benzimidazoles; Biological Transport; Cells, Cultured; Colchicine; Cricetinae; Cricetulus; Griseofulvin; HeLa Cells; Humans; Lignans; Maytansine; Mice; Mitosis; Nocodazole; Podophyllotoxin; Species Specificity; Vinblastine | 1985 |
The effects of colchicine analogues on the reaction of tubulin with iodo[14C]acetamide and N,N'-ethylenebis(iodoacetamide).
Topics: Alkylation; Animals; Benzaldehydes; Benzimidazoles; Colchicine; Ethylenediamines; Iodoacetamide; Iodoacetates; Mathematics; Nocodazole; Podophyllotoxin; Rabbits; Tropolone; Tubulin | 1985 |
N,N'-Ethylene-bis(iodoacetamide) as a probe for structural and functional characteristics of brine shrimp, squid, and bovine tubulins.
Topics: Alkylation; Animals; Artemia; Benzimidazoles; Cattle; Cell Fractionation; Colchicine; Cross-Linking Reagents; Decapodiformes; Ethylenediamines; Maytansine; Microtubules; Molecular Weight; Nocodazole; Podophyllotoxin; Species Specificity; Tubulin; Vinblastine | 1985 |
Effects of inhibitors of tubulin polymerization on GTP hydrolysis.
Topics: Animals; Benzimidazoles; Brain; Carbamates; Cattle; Colchicine; GTP Phosphohydrolases; Kinetics; Macromolecular Substances; Maytansine; Nocodazole; Oxazines; Phosphoric Monoester Hydrolases; Podophyllotoxin; Solvents; Structure-Activity Relationship; Tubulin; Vinblastine | 1981 |
Vinblastine inhibits the maturation of the precursor of mitochondrial aspartate aminotransferase. Vincristine and six other cytoskeleton inhibitors do not show this effect.
Topics: Alkaloids; Animals; Aspartate Aminotransferases; Benzimidazoles; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Chick Embryo; Colchicine; Cytochalasin D; Cytochalasins; Enzyme Precursors; Fibroblasts; Kinetics; Mitochondria; Nocodazole; Oxygen Consumption; Paclitaxel; Phalloidine; Podophyllotoxin; Vinblastine | 1983 |
Different effects of tubulin ligands on the intrachain cross-linking of beta 1-tubulin.
Topics: Animals; Benzimidazoles; Brain Chemistry; Cattle; Colchicine; Cross-Linking Reagents; Ethylenediamines; Female; Guanosine Triphosphate; Ligands; Magnesium; Magnesium Chloride; Maytansine; Nocodazole; Podophyllotoxin; Tubulin; Vinblastine | 1984 |
Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross-resistance studies with various microtubule inhibitors and podophyllotoxin analogues.
Topics: Animals; Benzimidazoles; Cell Line; Cell Survival; Colchicine; Cricetinae; Cricetulus; Drug Resistance; Female; Microtubules; Mutation; Nocodazole; Ovary; Podophyllotoxin; Structure-Activity Relationship; Vinblastine | 1983 |
Structural and functional diversity in the neuronal microtubules of Caenorhabditis elegans.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Caenorhabditis; Carbamates; Cilia; Colchicine; Microscopy, Electron; Microtubules; Neurons; Nocodazole; Podophyllotoxin; Temperature; Vinblastine | 1982 |
Toxicity of microtubular drugs to leukemic lymphocytes.
Topics: Benzimidazoles; Carbamates; Colchicine; Humans; Leukemia, Lymphoid; Lymphocytes; Maytansine; Microtubules; Nocodazole; Podophyllotoxin; Tropolone; Vinblastine; Vincristine | 1981 |
Possible involvement of microtubules in platelet-activating factor-induced increases in microvascular permeability in vitro.
Topics: Animals; Capillary Permeability; Demecolcine; In Vitro Techniques; Intestine, Small; Microtubules; Nocodazole; Perfusion; Platelet Activating Factor; Podophyllotoxin; Rats | 1993 |
Involvement of microtubules in prothoracicotropic hormone-stimulated ecdysteroidogenesis by insect (Manduca sexta) prothoracic glands.
Topics: Actin Cytoskeleton; Animals; Colchicine; Cytochalasin B; Cytochalasin D; Ecdysteroids; Endocrine Glands; In Vitro Techniques; Insect Hormones; Manduca; Microtubules; Nocodazole; Podophyllotoxin; Steroids | 1996 |
Posttranslational modification of tubulin by palmitoylation: I. In vivo and cell-free studies.
Topics: Animals; Blood Platelets; Brain Chemistry; Cell Membrane; Cell-Free System; Demecolcine; Guanosine Triphosphate; Humans; Male; Microtubules; Nocodazole; Paclitaxel; Palmitoyl Coenzyme A; Podophyllotoxin; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Substrate Specificity; Swine; Thrombin; Tubulin; Vinblastine | 1997 |
Use of drugs to study role of microtubule assembly dynamics in living cells.
Topics: Alkaloids; Antineoplastic Agents; Biopolymers; Cell Line; Colchicine; Drug Synergism; Microtubules; Molecular Weight; Nocodazole; Paclitaxel; Podophyllotoxin; Tubulin; Vinblastine | 1998 |
Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay.
Topics: Alkylation; Animals; Antineoplastic Agents; Binding Sites; Cattle; Colchicine; Iodoacetamide; Nocodazole; Podophyllotoxin; Pyridones; Spectrometry, Fluorescence; Structure-Activity Relationship; Tubulin | 1998 |
Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Colchicine; Egtazic Acid; Enzyme Activation; Humans; Microtubules; Nocodazole; Paclitaxel; Podophyllotoxin; Tumor Cells, Cultured; Vincristine | 1999 |
alphaB-Crystallin-coated MAP microtubule resists nocodazole and calcium-induced disassembly.
Topics: alpha-Crystallin B Chain; Animals; Calcium; Cattle; Cell Line; Cell Line, Tumor; Microscopy, Fluorescence; Microtubule-Associated Proteins; Microtubules; Nocodazole; Oligonucleotides, Antisense; Podophyllotoxin; Protein Binding; Rats | 2004 |
A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.
Topics: 2-Methoxyestradiol; 4-Butyrolactone; Aminophenols; Binding Sites; Chalcone; Colchicine; Cyclopropanes; Estradiol; Indans; Lignans; Models, Molecular; Molecular Structure; Nocodazole; Podophyllotoxin; Protein Binding; Stilbenes; Structure-Activity Relationship; Sulfonamides; Thiazoles; Tubulin; Tubulin Modulators | 2005 |