Page last updated: 2024-08-21

podophyllotoxin and lignans

podophyllotoxin has been researched along with lignans in 105 studies

Research

Studies (105)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (11.43)	18.7374
1990's	5 (4.76)	18.2507
2000's	44 (41.90)	29.6817
2010's	27 (25.71)	24.3611
2020's	17 (16.19)	2.80

Authors

Authors	Studies
Arimoto, M; Numata, A; Yamaguchi, H; Yamamoto, K	1
Kupchan, SM; Rebhum, LI; Wang, RW	1
Hudson, JB; MacRae, WD; Towers, GH	1
Gupta, RS	1
Maibach, HI; von Krogh, G	2
Tomioka, K	1
Atchison, K; Daneshtalab, M; Kamal, A; Micetich, RG	1
Landberg, G; Norberg, B; Rantapää Dahlqvist, S; Roos, G	1
Sackett, DL	1
Anttila, VJ; Isomäki, HA; Kauppi, M; Savolainen, HA	1
Rosén, B	1
Axelson, M; Carlström, K; Hedin, PJ; Jönsson, L; Lerndal, T; Lien, J; Weitoft, T	1
Kwan, SY; Lin, RC; Su, XL; Tsui, SK; Wong, SK	1
Costa, MA; Davin, LB; Lewis, NG; Proctor, J; Xia, ZQ	1
Dantzig, A; LaLonde, RT; Ramdayal, F; Shepard, RL; Yanai, K; Zhang, M	1
Khan, IA; Moraes, RM; Pasco, DS; Pugh, N	1
Alfermann, AW; Petersen, M	1
Huang, J; Nagatsu, A; Ogihara, Y; Zhao, C	1
Angeles Castro, M; García-García, PA; Gordaliza, M; Miguel del Corral, JM; San Feliciano, A	1
Azambuja, P; Cabral, MM; Garcia, ES; Gottlieb, OR	1
Botta, B; Delle Monache, G; Misiti, D; Vitali, A; Zappia, G	1
Shi, D; Zhang, M	1
Bos, R; Koulman, A; Medarde, M; Pras, N; Quax, WJ	1
Alfermann, AW; Empt, U; Kuhlmann, S; Molog, GA; Petersen, M; Pras, N; van Uden, W	1
Barrett, H; Bedir, E; Burandt, C; Canel, C; Khan, IA; Moraes, RM	1
Alfermann, AW; Arroo, RR; Eaton, G; Medarde, M; Petersen, M; Seidel, V; Windhövel, J; Woolley, JG	1
Caballero, E; Madrigal, B; Medarde, M; Peláez, R; Puebla, P	1
Castro, A; del Corral, JM; García-Grávalos, D; Gómez-Zurita, A; Gordaliza, M; Grande, C; San Feliciano, A	1
Kranz, K; Petersen, M	1
LaLonde, RT; Zhang, M	1
Chang, HW; Ju, HK; Kim, MJ; Kim, SH; Lee, E; Lee, SH; Lin, CX; Moon, TC; Son, JK; Son, MJ	1
Abdel-Mogib, M; Al-Juaid, SS	1
Azambuja, P; Garcia, ES	1
Castro, MA; del Corral, JM; García, PA; Gómez-Zurita, MA; Gordaliza, M	1
Ionkova, I; Vasilev, N	1
Fuss, E; Humburg, A; van Fürden, B	1
Belfiore, MC; Fiani, C; Gualandi, G; Mosesso, P; Penna, S; Saladino, R	1
Berim, A; Boland, W; Conrad, J; Maitrejean, M; Petersen, M; Spring, O	1
Burnett, JC; Day, BW; Gussio, R; Hamel, E; Hermone, AR; McGrath, C; Nguyen, TL; Wipf, P; Zaharevitz, DW	1
Bunyapraphatsara, N; Fong, HH; Jutiviboonsuk, A; Ma, C; Manh Cuong, N; Soejarto, DD; Tan, GT; Van Hung, N; Zhang, H	1
Ahmed, B; Amna, T; Arora, R; Chawla, R; Kumar, R; Nazir, A; Puri, SC; Qazi, GN; Riyaz-Ul-Hasan, S; Sagar, R; Sharma, A; Sharma, RK; Singh, S; Verma, V	1
But, PP; Hon, PM; Jiang, RW; Li, LL; Li, SL; Shaw, PC; Xu, HX; Ye, WC; Zhou, JR; Zhou, Y	1
Alfermann, AW; Federolf, K; Fuss, E	1
Bousserouel, H; Dumontet, V; Guéritte, F; Léonce, S; Litaudon, M; Martin, MT; Sévenet, T; Thoison, O; Zhang, YJ	1
Cafici, L; Canonico, PL; Galli, U; Genazzani, AA; Imperio, D; Pagliai, F; Pirali, T; Sorba, G; Tron, GC	1
Akhmedjanova, V; Balansard, G; Barthomeuf, C; Beliveau, R; Debiton, E; Grassi, J; Lim, S	1
Fliniaux, MA; Fliniaux, O; Hano, C; Lainé, E; Lamblin, F; Mesnard, F	1
Fliniaux, MA; Lautié, E; Quintero, R; Villarreal, ML	1
Chang, HW; Chang, YC; Choi, HS; Jin, UH; Kim, CH; Kim, JR; Kim, SH; Lee, IS; Lee, YC; Moon, TC; Suh, SJ	1
Adelt, I; Antonicek, H; Arnold, C; Behrmann, P; Blaha, N; Böhmer, J; Frackenpohl, J; Gutbrod, O; Hanke, R; Hohmann, S; Lösel, P; Malsam, O; Melchers, M; Neufert, V; Peschel, E; Reckmann, U; Schenke, T; Thiesen, HP; van Houtdreve, M; Velten, R; Vogelsang, K; Weiss, HC	1
Ellendorff, T; Klaes, M; Schmidt, TJ	1
Gui, J; Hu, Q; Hu, Y; Qu, Y; Wang, S; Wei, Y; Wu, F	1
David, JM; David, JP; Guedes, ML; Lima, LS; Martins, LC; Santos, EO	1
Chen, H; Hua, HM; Li, ZL; Liu, XQ; Sun, YJ; Zhou, W	1
Ionkova, I	1
Araki, R; Behmanesh, M; Esmaeilzadeh Bahabadi, S; Murata, J; Safaie, N; Satake, H; Sharifi, M; Yamagaki, T	1
Huang, K; Jiang, W; Liu, X; Qin, S; Wang, C; Zhang, Z; Zhao, J; Zhong, G	1
Alvarez, L; Delgado, JI; Marquina, S; Mendieta-Serrano, M; Mojica, MY; Puebla, AM; Rojas-Sepúlveda, AM; Salas-Vidal, E; Villarreal, ML	1
Chau, VM; Guéritte, F; Litaudon, M; Mai, HD; Nguyen, VH; Pham, VC; Retailleau, P; Thanh, VT	1
Costa, MA; Crow, JA; Davin, LB; Kim, KW; Lee, C; Lewis, NG; Marques, JV; May, GD	1
Biswas, DK; Rajkumar, S; Sinha, AK; Wankhede, DP	1
Maimone, TJ; Ting, CP	1
Wang, Y; Xiao, X; Xu, H; Yang, C; Yu, X; Zhi, X	1
Boitel, M; Colas, C; Cong, LH; Corbin, C; Dauwe, R; Doussot, J; Fliniaux, O; Gontier, E; Hano, C; Jullian, N; Laberche, JC; Lamblin, F; Lequart, M; Mesnard, F; Molinié, R; Pilard, S; Renouard, S; Vinchon, S	1
Gao, W; Gong, JH; Guan, YB; Sun, YJ; Wang, JM; Wang, Y; Zhang, YL; Zhao, X	1
Jiang, W; Li, M; Liang, J; Wu, AL; Zhang, SW; Zhong, GY	1
Alvarez, L; Antúnez-Mojica, M; Barasoain, I; Cañada, FJ; Canales, Á; Díaz, JF; Jiménez-Barbero, J; León, A; Redondo-Horcajo, M; Rodríguez-Salarichs, J	1
Álvarez-Berber, L; Meneses-Acosta, A; Peña-Morán, OA; Rodríguez-López, V; Villarreal, ML	1
Colas, C; Corbin, C; Doussot, J; Dupré, P; Hano, C; Kiss, R; Lainé, E; Lamblin, F; Mathieu, V; Maunit, B; Molinié, R; Montguillon, J; Moreno Y Banuls, L; Renouard, S	1
Nan, G; Peng, Y; Wang, YW; Xiao, J	1
Li, J; Renata, H; Zhang, X	1
Alizade, V; Atha, D; Borris, RP; Hatada, AE; Khutsishvili, M; Ko'omoa-Lange, DL; Lange, I; Qiao, Y; Sunada, NK	1
Fragoso-Serrano, M; Pereda-Miranda, R	1
Castillo-Romero, A; Gutiérrez-Gutiérrez, F; Hernández-Hernández, JM; Puebla-Pérez, AM; Romo-Mancillas, A	1
Cui, Q; Du, R; Liu, M; Rong, L	1
Alvarenga, D; Brandão, GC; Costa, F; Ferreira, ACG; Munhoz, V; Pereira, GR; Reis, ACC; Silva, BM	1
Chae, JI; Cho, SS; Choi, JS; Kwak, AW; Lee, MH; Shim, JH; Yoon, G	1
Decembrino, D; Girhard, M; Jach, G; Ricklefs, E; Schullehner, K; Urlacher, VB; Wohlgemuth, S	1
Decembrino, D; Girhard, M; Knöfel, R; Raffaele, A; Urlacher, VB	1
Berežni, S; Mimica-Dukić, N; Orčić, D; Škorić, D	1
Anaya-Ruíz, M; González-Christen, J; Millán-Pacheco, C; Peña-Morán, OA; Rodríguez-López, V	1
Anoop, A; Garai, S; Hajra, S; Roy, S; Sen, B	1
Abbaszadeh, H; Mottaghi, S	1
Gao, W; Huang, L; Luo, Y; Shen, S; Tong, Y	1
Al-Omari, B; Calina, D; Cho, WC; Ekiert, H; Jafernik, K; Motyka, S; Sharifi-Rad, J; Szopa, A	1
Gründemann, C; Gupta, MP; Hamburger, M; Keller, M; Potterat, O; Solis, PN; Sperisen, N; Winker, M; Zimmermann-Klemd, AM	1
Bai, H; Feng, W; Han, R; Li, M; Sun, Y; Wang, H; Wang, J	1
Sagharyan, M; Samari, E; Sharifi, M	1
Bakhtiarizadeh, MR; Danaeipour, Z; Garoosi, G; Mirjalili, MH; Tohidfar, M	1
Larsen, A; Petersson, I; Svensson, B	1
Costa, MA; Davin, LB; Lewis, NG; Pelissier, HC; Xia, ZQ	1
Chen, X; Hu, Z; Liu, S; Tian, X	1
Hatano, K; Kato, S; Nagatsu, A; Ogihara, Y; Shirai, N; Zhao, C	1
CHAKRAVARTI, SC; CHATTERJEE, R	1
PADAWER, J	1
AUTERHOFF, H; THEILACKER, G	2
Davin, LB; Kang, C; Lewis, NG; Moinuddin, SG; Youn, B	1
Adhikari, M; Arora, R; Chawla, R; Dhaker, AS; Gupta, D; Kumar, R; Sharma, A; Sharma, J; Sharma, RK; Singh, S; Tripathi, RP	1
An, Q; Dong, Y; Li, N; Lu, N	1
Hollanda, PO; Honório, NA; Maleck, M; Serdeiro, MT; Silva, CG; Soares, RO	1
Almeida, VL; Campana, PRV; Lopes, JCD; Rocha, MP; Scoaris, DO; Shaw, JMH; Silva, CG	1
Kim, SS; Sattely, ES	1

Reviews

12 review(s) available for podophyllotoxin and lignans

Article	Year
[Asymmetric total synthesis of some biologically active natural products]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1984, Volume: 104, Issue:10 Topics: 4-Butyrolactone; Alkaloids; Antineoplastic Agents, Phytogenic; Chemical Phenomena; Chemistry; Dioxoles; Furans; Galantamine; Lactones; Lignans; Methods; Molecular Conformation; Optical Rotation; Podophyllotoxin	1984
Podophyllotoxin, steganacin and combretastatin: natural products that bind at the colchicine site of tubulin. Pharmacology & therapeutics, 1993, Volume: 59, Issue:2 Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Bibenzyls; Binding Sites; Cell Division; Lignans; Podophyllotoxin; Polymers; Stilbenes; Structure-Activity Relationship; Tubulin	1993
The production of cytotoxic lignans by plant cell cultures. Applied microbiology and biotechnology, 2001, Volume: 55, Issue:2 Topics: Cell Culture Techniques; Cell Line; Cells, Cultured; Lignans; Plant Cells; Plant Roots; Plant Structures; Plants; Podophyllotoxin	2001
Aryltetralin lignans: chemistry, pharmacology and biotransformations. Current medicinal chemistry, 2001, Volume: 8, Issue:11 Topics: Animals; Antineoplastic Agents, Phytogenic; Biotransformation; Humans; Lignans; Podophyllotoxin	2001
Lignoids in insects: chemical probes for the study of ecdysis, excretion and Trypanosoma cruzi-triatomine interactions. Toxicon : official journal of the International Society on Toxinology, 2004, Sep-15, Volume: 44, Issue:4 Topics: Animals; Benzofurans; Dioxoles; Feeding Behavior; Furans; Host-Parasite Interactions; Insecta; Larva; Lignans; Malpighian Tubules; Masoprocol; Molting; Podophyllotoxin; Rhodnius; Trypanosoma cruzi	2004
Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives. Toxicon : official journal of the International Society on Toxinology, 2004, Sep-15, Volume: 44, Issue:4 Topics: Cytotoxins; Etoposide; Lignans; Organophosphorus Compounds; Plants, Toxic; Podophyllotoxin; Teniposide; Tumor Cells, Cultured	2004
[Interest of lignans in prevention and treatment of cancers]. Medecine sciences : M/S, 2008, Volume: 24, Issue:5 Topics: Anticarcinogenic Agents; Antineoplastic Agents; Humans; Lignans; Neoplasms; Phytoestrogens; Podophyllotoxin	2008
Anticancer lignans--from discovery to biotechnology. Mini reviews in medicinal chemistry, 2011, Volume: 11, Issue:10 Topics: Antineoplastic Agents, Phytogenic; Biotechnology; Cell Survival; Humans; Lignans; Plant Cells; Podophyllotoxin	2011
Lignans and Their Derivatives from Plants as Antivirals. Molecules (Basel, Switzerland), 2020, Jan-01, Volume: 25, Issue:1 Topics: Antiviral Agents; Benzodioxoles; Biological Products; Biphenyl Compounds; Drug Development; Furans; Lignans; Masoprocol; Plants; Podophyllotoxin	2020
A comprehensive insight into the antineoplastic activities and molecular mechanisms of deoxypodophyllotoxin: Recent trends, challenges, and future outlook. European journal of pharmacology, 2022, Aug-05, Volume: 928 Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Drugs, Chinese Herbal; Humans; Lignans; Neoplasms; Phosphatidylinositol 3-Kinases; Podophyllotoxin	2022
Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives. Natural product reports, 2022, 09-21, Volume: 39, Issue:9 Topics: Biosynthetic Pathways; Catalysis; Lignans; Podophyllotoxin	2022
Podophyllotoxin and its derivatives: Potential anticancer agents of natural origin in cancer chemotherapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 158 Topics: Antineoplastic Agents; Antiviral Agents; Humans; Lignans; Neoplasms; Podophyllotoxin	2023

Trials

3 trial(s) available for podophyllotoxin and lignans

Article	Year
Endocrine effects of the podophyllotoxine derivative drug CPH 82 (Reumacon) in patients with rheumatoid arthritis. Scandinavian journal of rheumatology, 2000, Volume: 29, Issue:2 Topics: Adrenocorticotropic Hormone; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Endocrine Glands; Female; Glycosides; Homeostasis; Humans; Lignans; Male; Middle Aged; Podophyllotoxin; Steroids; Tumor Necrosis Factor-alpha	2000
CPH 82. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 2003, Volume: 17, Issue:5 Topics: Administration, Oral; Arthritis, Rheumatoid; Clinical Trials as Topic; Glycosides; Humans; Lignans; Paclitaxel; Podophyllotoxin	2003
Podophyllum derivatives (CPH 82) compared with placebo in the treatment of rheumatoid arthritis. British journal of rheumatology, 1989, Volume: 28, Issue:2 Topics: Arthritis, Rheumatoid; Gastrointestinal Diseases; Glycosides; Humans; Lignans; Placebos; Plant Extracts; Plants, Medicinal; Plants, Toxic; Podophyllum	1989

Other Studies

90 other study(ies) available for podophyllotoxin and lignans

Article	Year
[Studies on the constituents of the seeds of Hernandia ovigera L. (author's transl)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1979, Volume: 99, Issue:6 Topics: Benzyl Compounds; Drugs, Chinese Herbal; Lactones; Lignans; Plant Extracts; Plants, Medicinal; Podophyllin; Podophyllotoxin; Seeds	1979
Antimitotic and antitubulin activity of the tumor inhibitor steganacin. Cancer research, 1977, Volume: 37, Issue:9 Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Binding, Competitive; Cell Division; Colchicine; Cycloparaffins; Female; Glycoproteins; Lactones; Lignans; Microtubules; Mitosis; Ovum; Podophyllotoxin; Sea Urchins; Tubulin; Tubulin Modulators; Ultracentrifugation	1977
The antiviral action of lignans. Planta medica, 1989, Volume: 55, Issue:6 Topics: Antiviral Agents; Cytomegalovirus; Lignans; Lignin; Molecular Structure; Plants; Podophyllotoxin; Sindbis Virus	1989
Species-specific differences in toxicity of antimitotic agents toward cultured mammalian cells. Journal of the National Cancer Institute, 1985, Volume: 74, Issue:1 Topics: 4-Butyrolactone; Animals; Benzimidazoles; Biological Transport; Cells, Cultured; Colchicine; Cricetinae; Cricetulus; Griseofulvin; HeLa Cells; Humans; Lignans; Maytansine; Mice; Mitosis; Nocodazole; Podophyllotoxin; Species Specificity; Vinblastine	1985
Cutaneous cytodestructive potency of lignans. I. A comparative evaluation of influence on epidermal and dermal DNA synthesis and on dermal microcirculation in the hairless mouse. Archives of dermatological research, 1982, Volume: 274, Issue:1-2 Topics: Animals; Cell Cycle; DNA; Epidermis; Lignans; Male; Mice; Mice, Hairless; Microcirculation; Plant Extracts; Podophyllotoxin; Skin	1982
Cutaneous cytodestructive potency of lignans. II. A comparative evaluation of macroscopic-toxic influence on rabbit skin subsequent to repeated 10-day applications. Dermatologica, 1983, Volume: 167, Issue:2 Topics: Administration, Topical; Animals; Antineoplastic Agents, Phytogenic; Condylomata Acuminata; Humans; Kinetics; Lignans; Necrosis; Plant Extracts; Podophyllotoxin; Rabbits; Skin; Skinfold Thickness	1983
Synthesis of podophyllotoxin congeners as potential DNA topoisomerase II inhibitors. Anti-cancer drug design, 1995, Volume: 10, Issue:7 Topics: Animals; Antineoplastic Agents, Phytogenic; Cattle; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Lignans; Podophyllotoxin; Thymus Gland; Topoisomerase II Inhibitors; Tumor Cells, Cultured	1995
Cell cycle effects of the anti-rheumatic agent CPH82. British journal of rheumatology, 1994, Volume: 33, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Cycle; Cell Line; DNA; Glycosides; Humans; Lignans; Nuclear Proteins; Paclitaxel; Podophyllotoxin; Proliferating Cell Nuclear Antigen	1994
Leukaemia during podophyllotoxin treatment in a patient with juvenile chronic arthritis. Scandinavian journal of rheumatology, 1996, Volume: 25, Issue:5 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Glycosides; Humans; Leukemia; Lignans; Neoplasms, Second Primary; Podophyllotoxin	1996
Difference in pharmacological activity between CPH 82 and podophyllotoxin. Scandinavian journal of rheumatology, 1998, Volume: 27, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Glycosides; Humans; Lignans; Podophyllotoxin	1998
Identification and characterization of Podophyllum emodi by API-LC/MS/MS. Journal of mass spectrometry : JMS, 2000, Volume: 35, Issue:11 Topics: Biomarkers; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lignans; Mass Spectrometry; Molecular Structure; Plants, Medicinal; Plants, Toxic; Podophyllotoxin; Podophyllum; Reference Standards; Tetrahydronaphthalenes	2000
Dirigent-mediated podophyllotoxin biosynthesis in Linum flavum and Podophyllum peltatum. Phytochemistry, 2000, Volume: 55, Issue:6 Topics: Amino Acid Sequence; Antineoplastic Agents; Base Sequence; DNA, Plant; Flax; Furans; Lignans; Molecular Sequence Data; Plant Proteins; Plants, Medicinal; Plants, Toxic; Podophyllotoxin; Podophyllum; Sequence Homology, Amino Acid	2000
Cytotoxic responses to aromatic ring and configurational variations in alpha-conidendrin, podophyllotoxin, and sikkimotoxin derivatives. Journal of medicinal chemistry, 2001, Jan-18, Volume: 44, Issue:2 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Lignans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Multidrug Resistance-Associated Proteins; Podophyllotoxin; Structure-Activity Relationship; Tetrahydronaphthalenes; Tumor Cells, Cultured	2001
Podophyllotoxin lignans enhance IL-1beta but suppress TNF-alpha mRNA expression in LPS-treated monocytes. Immunopharmacology and immunotoxicology, 2001, Volume: 23, Issue:1 Topics: Cells, Cultured; Electrophoresis, Agar Gel; Gene Expression Regulation; Humans; Interleukin-1; Interleukin-1beta; Lignans; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Monocytes; NF-kappa B; Peptide Fragments; Podophyllotoxin; RNA, Messenger; Structure-Activity Relationship; Time Factors; Tumor Necrosis Factor-alpha	2001
Two new podophyllotoxin glucosides from Sinopodophyllum emodi (Wall.) Ying. Chemical & pharmaceutical bulletin, 2001, Volume: 49, Issue:6 Topics: Glucosides; Lignans; Magnoliopsida; Molecular Structure; Podophyllotoxin; Spectrum Analysis	2001
Cytotoxic cyclolignans related to podophyllotoxin. Farmaco (Societa chimica italiana : 1989), 2001, Volume: 56, Issue:4 Topics: Aldehydes; Animals; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Lignans; Mice; Molecular Conformation; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured	2001
Effects of some lignans and neolignans on the development and excretion of Rhodnius prolixus. Fitoterapia, 2000, Volume: 71, Issue:1 Topics: Animals; Benzofurans; Dioxoles; Feeding Behavior; Furans; Larva; Lauraceae; Lignans; Masoprocol; Plants, Medicinal; Podophyllotoxin; Rhodnius	2000
[Determination of podophyllotoxin lignans in Dysosma and its allied plants]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2001, Volume: 24, Issue:6 Topics: Berberidaceae; Lignans; Plant Roots; Plant Stems; Plants, Medicinal; Podophyllotoxin	2001
A fast and simple GC MS method for lignan profiling in Anthriscus sylvestris and biosynthetically related Plant species. Planta medica, 2001, Volume: 67, Issue:9 Topics: 4-Butyrolactone; Apiaceae; Dioxoles; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lignans; Plant Extracts; Podophyllotoxin	2001
Deoxypodophyllotoxin 6-hydroxylase, a cytochrome P450 monooxygenase from cell cultures of Linum flavum involved in the biosynthesis of cytotoxic lignans. Planta, 2001, Volume: 214, Issue:2 Topics: Cells, Cultured; Cytochrome c Group; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Flax; Hydrogen-Ion Concentration; Lignans; Microsomes; NAD; NADP; Podophyllotoxin; Substrate Specificity	2001
Evaluation of Podophyllum peltatum accessions for podophyllotoxin production. Planta medica, 2002, Volume: 68, Issue:4 Topics: Biomass; Lignans; Plant Leaves; Plant Stems; Podophyllotoxin; Podophyllum	2002
Biosynthesis of podophyllotoxin in Linum album cell cultures. Planta, 2002, Volume: 215, Issue:6 Topics: Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Carbon Isotopes; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Cinnamates; Coenzyme A Ligases; Coumaric Acids; Drugs, Chinese Herbal; Flax; Hydrogen-Ion Concentration; Lignans; Mass Spectrometry; Molecular Structure; Phenylalanine Ammonia-Lyase; Podophyllotoxin	2002
Naphthalene analogues of lignans. The Journal of organic chemistry, 2003, Feb-07, Volume: 68, Issue:3 Topics: Carbazoles; Catalysis; Chemistry, Organic; Cyclization; Esterification; Indicators and Reagents; Lignans; Magnetic Resonance Spectroscopy; Molecular Structure; Naphthalenes; Podophyllotoxin; Stereoisomerism	2003
Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring. European journal of medicinal chemistry, 2003, Volume: 38, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dioxanes; Dioxoles; Drug Screening Assays, Antitumor; Humans; Lignans; Magnetic Resonance Spectroscopy; Mice; Models, Chemical; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship	2003
Beta-peltatin 6-O-methyltransferase from suspension cultures of Linum nodiflorum. Phytochemistry, 2003, Volume: 64, Issue:2 Topics: Drugs, Chinese Herbal; Enzyme Inhibitors; Flax; Hydrogen-Ion Concentration; Lignans; Methyltransferases; Podophyllotoxin; S-Adenosylmethionine; Substrate Specificity; Temperature; Time Factors	2003
Alpha-conidendrin as a source for preparation of sikkimotoxin derivatives. Journal of natural products, 2004, Volume: 67, Issue:4 Topics: Catalysis; Indicators and Reagents; Lignans; Oxidation-Reduction; Podophyllotoxin; Quinones; Structure-Activity Relationship; Tetrahydronaphthalenes	2004
Deoxypodophyllotoxin, a naturally occurring lignan, inhibits the passive cutaneous anaphylaxis reaction. Planta medica, 2004, Volume: 70, Issue:5 Topics: Animals; Apiaceae; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hypersensitivity, Immediate; Injections, Intraperitoneal; Injections, Intravenous; Lignans; Male; Passive Cutaneous Anaphylaxis; Phytotherapy; Plant Extracts; Plant Roots; Podophyllotoxin; Rats; Rats, Sprague-Dawley	2004
A novel podophyllotoxin lignan from Justicia heterocarpa. Chemical & pharmaceutical bulletin, 2004, Volume: 52, Issue:5 Topics: Justicia; Lignans; Plant Components, Aerial; Plant Extracts; Podophyllotoxin	2004
Lignan accumulation in cell cultures of Linum strictum ssp. strictum L. Acta pharmaceutica (Zagreb, Croatia), 2004, Volume: 54, Issue:4 Topics: Biotechnology; Cell Culture Techniques; Cells, Cultured; Flax; Lignans; Plant Roots; Plant Shoots; Podophyllotoxin; Seeds	2004
Influence of methyl jasmonate on podophyllotoxin and 6-methoxypodophyllotoxin accumulation in Linum album cell suspension cultures. Plant cell reports, 2005, Volume: 24, Issue:5 Topics: Acetates; Alcohol Oxidoreductases; Cell Culture Techniques; Cyclopentanes; Flax; Lignans; Oxylipins; Phenylalanine Ammonia-Lyase; Podophyllotoxin	2005
Methyltrioxorhenium catalysed synthesis of highly oxidised aryltetralin lignans with anti-topoisomerase II and apoptogenic activities. Bioorganic & medicinal chemistry, 2005, Nov-01, Volume: 13, Issue:21 Topics: Animals; Apoptosis; Catalysis; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; Enzyme Inhibitors; Humans; Lignans; Molecular Structure; Organometallic Compounds; Oxidation-Reduction; Podophyllotoxin; Tetrahydronaphthalenes; Topoisomerase II Inhibitors	2005
Enhancement of lignan biosynthesis in suspension cultures of Linum nodiflorum by coronalon, indanoyl-isoleucine and methyl jasmonate. Planta, 2005, Volume: 222, Issue:5 Topics: Acetates; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclopentanes; Flax; Isoleucine; Lignans; Magnetic Resonance Spectroscopy; Molecular Structure; Oxylipins; Plant Growth Regulators; Podophyllotoxin	2005
A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. Journal of medicinal chemistry, 2005, Sep-22, Volume: 48, Issue:19 Topics: 2-Methoxyestradiol; 4-Butyrolactone; Aminophenols; Binding Sites; Chalcone; Colchicine; Cyclopropanes; Estradiol; Indans; Lignans; Models, Molecular; Molecular Structure; Nocodazole; Podophyllotoxin; Protein Binding; Stilbenes; Structure-Activity Relationship; Sulfonamides; Thiazoles; Tubulin; Tubulin Modulators	2005
Bioactive constituents from roots of Bursera tonkinensis. Phytochemistry, 2005, Volume: 66, Issue:23 Topics: Antineoplastic Agents, Phytogenic; Bursera; Drug Screening Assays, Antitumor; Humans; Lignans; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Plant Roots; Podophyllotoxin; Tumor Cells, Cultured	2005
The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans. Journal of biotechnology, 2006, Apr-20, Volume: 122, Issue:4 Topics: Cell Fractionation; Chromatography, High Pressure Liquid; Fungi; Kinetics; Lignans; Lipid Peroxidation; Models, Biological; Plant Cells; Plant Structures; Plants; Podophyllotoxin; Podophyllum; Spectrometry, Mass, Electrospray Ionization; Tetrahydronaphthalenes	2006
Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines. Journal of natural products, 2007, Volume: 70, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Berberidaceae; Drug Screening Assays, Antitumor; Humans; Lignans; Male; Molecular Structure; Plant Roots; Plants, Medicinal; Podophyllotoxin; Prostatic Neoplasms; Rhizome; Tumor Cells, Cultured	2007
Aryltetralin-lignan formation in two different cell suspension cultures of Linum album: deoxypodophyllotoxin 6-hydroxylase, a key enzyme for the formation of 6-methoxypodophyllotoxin. Phytochemistry, 2007, Volume: 68, Issue:10 Topics: Biotransformation; Cells, Cultured; Flax; Lignans; Mixed Function Oxygenases; Models, Chemical; Plant Extracts; Plant Proteins; Podophyllotoxin	2007
Sesquiterpenoids and cytotoxic lignans from the bark of Libocedrus chevalieri. Journal of natural products, 2007, Volume: 70, Issue:8 Topics: Antineoplastic Agents, Phytogenic; Cupressaceae; Drug Screening Assays, Antitumor; Humans; KB Cells; Lignans; Molecular Structure; New Caledonia; Plant Bark; Plants, Medicinal; Podophyllotoxin; Sesquiterpenes	2007
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry. Bioorganic & medicinal chemistry, 2007, Nov-01, Volume: 15, Issue:21 Topics: 4-Butyrolactone; Antineoplastic Agents; Catalysis; Cell Line, Tumor; Humans; Lactones; Lignans; Molecular Conformation; Podophyllotoxin; Ruthenium; Triazoles; Tubulin	2007
Reversal of P-glycoprotein-mediated drug efflux by eudesmin from Haplophyllum perforatum and cytotoxicity pattern versus diphyllin, podophyllotoxin and etoposide. Planta medica, 2007, Volume: 73, Issue:15 Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Cell Line, Tumor; Dioxolanes; Drug Resistance, Neoplasm; Etoposide; Furans; Humans; Lignans; Phytotherapy; Plant Extracts; Plant Leaves; Plant Roots; Podophyllotoxin; Rutaceae	2007
Selection methodology with scoring system: application to Mexican plants producing podophyllotoxin related lignans. Journal of ethnopharmacology, 2008, Dec-08, Volume: 120, Issue:3 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Humans; Lignans; Mexico; Neoplasms; Phytotherapy; Plant Extracts; Plants, Medicinal; Podophyllotoxin; Research Design	2008
Deoxypodophyllotoxin, flavolignan, from Anthriscus sylvestris Hoffm. inhibits migration and MMP-9 via MAPK pathways in TNF-alpha-induced HASMC. Vascular pharmacology, 2009, Volume: 51, Issue:1 Topics: Aorta; Apiaceae; Cell Migration Inhibition; Cells, Cultured; Drugs, Chinese Herbal; Humans; Lignans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Myocytes, Smooth Muscle; Plant Extracts; Plant Roots; Podophyllotoxin; Protease Inhibitors; Tumor Necrosis Factor-alpha	2009
Insecticidal heterolignans--tubuline polymerization inhibitors with activity against chewing pests. Bioorganic & medicinal chemistry, 2009, Jun-15, Volume: 17, Issue:12 Topics: Animals; Coleoptera; Computer Simulation; Crystallography, X-Ray; Insecticides; Lepidoptera; Lignans; Podophyllotoxin; Structure-Activity Relationship; Tubulin Modulators	2009
6-methoxypodophyllotoxin-7-O-n-hexanoate, a new aryltetralin lignan ester from seeds of Linum flavum. Planta medica, 2010, Volume: 76, Issue:7 Topics: Flax; Lignans; Podophyllotoxin; Seeds	2010
Tuned C-H functionalization to construct aza-podophyllotoxin/aza-conidendrin derivatives by means of domino cyclization. Chemistry, an Asian journal, 2010, Feb-01, Volume: 5, Issue:2 Topics: Aza Compounds; Crystallography, X-Ray; Cyclization; Lignans; Models, Molecular; Molecular Conformation; Podophyllotoxin; Tetrahydronaphthalenes	2010
Podophyllotoxin and other aryltetralin lignans from Eriope latifolia and Eriope blanchetii. Natural product research, 2011, Volume: 25, Issue:15 Topics: Chromatography, Thin Layer; Lamiaceae; Lignans; Magnetic Resonance Spectroscopy; Podophyllotoxin; Spectrometry, Mass, Electrospray Ionization; Tetrahydronaphthalenes	2011
Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi. Bioorganic & medicinal chemistry letters, 2011, Jun-15, Volume: 21, Issue:12 Topics: Antineoplastic Agents, Phytogenic; Berberidaceae; Cell Line, Tumor; Cell Survival; Glucosides; HeLa Cells; Humans; Inhibitory Concentration 50; Lignans; Magnetic Resonance Spectroscopy; Plant Roots; Podophyllotoxin	2011
Time-course changes in fungal elicitor-induced lignan synthesis and expression of the relevant genes in cell cultures of Linum album. Journal of plant physiology, 2012, Mar-15, Volume: 169, Issue:5 Topics: Aldehyde Oxidoreductases; Biosynthetic Pathways; Cells, Cultured; Flax; Furans; Fusarium; Gene Expression Regulation, Plant; Genes, Plant; Lignans; Oxidoreductases; Phenylalanine Ammonia-Lyase; Podophyllotoxin; Rhizopus	2012
[Determination of podophyllotoxin and total lignans in Sinopodophyllum emodi]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012, Volume: 37, Issue:10 Topics: Berberidaceae; Chromatography, High Pressure Liquid; Lignans; Podophyllotoxin; Spectrophotometry, Ultraviolet	2012
Cytotoxic podophyllotoxin type-lignans from the steam bark of Bursera fagaroides var. fagaroides. Molecules (Basel, Switzerland), 2012, Aug-09, Volume: 17, Issue:8 Topics: Animals; Antineoplastic Agents, Phytogenic; Bursera; Cell Line, Tumor; Humans; Lignans; Lymphoma; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Podophyllotoxin; Xenograft Model Antitumor Assays	2012
Cytotoxic lignans from fruits of Cleistanthus indochinensis: synthesis of cleistantoxin derivatives. Journal of natural products, 2012, Sep-28, Volume: 75, Issue:9 Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Euphorbiaceae; Fruit; Humans; Lignans; MCF-7 Cells; Molecular Structure; Podophyllotoxin; Vietnam	2012
Next generation sequencing in predicting gene function in podophyllotoxin biosynthesis. The Journal of biological chemistry, 2013, Jan-04, Volume: 288, Issue:1 Topics: Amino Acid Sequence; Catalysis; Computational Biology; Cytochrome P-450 Enzyme System; Databases, Factual; Gene Expression Regulation, Plant; Lignans; Microsomes; Models, Biological; Models, Chemical; Molecular Sequence Data; Plant Extracts; Plants, Medicinal; Podophyllotoxin; Podophyllum; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transcriptome	2013
Expressed sequence tags and molecular cloning and characterization of gene encoding pinoresinol/lariciresinol reductase from Podophyllum hexandrum. Protoplasma, 2013, Volume: 250, Issue:6 Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Base Sequence; Biosynthetic Pathways; Cloning, Molecular; Expressed Sequence Tags; Furans; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Library; Genes, Plant; Lignans; Molecular Sequence Data; NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases; Oxidoreductases; Phylogeny; Plant Proteins; Podophyllotoxin; Podophyllum; Sequence Alignment; Sequence Analysis, DNA; Stress, Physiological	2013
C-H bond arylation in the synthesis of aryltetralin lignans: a short total synthesis of podophyllotoxin. Angewandte Chemie (International ed. in English), 2014, Mar-17, Volume: 53, Issue:12 Topics: Biological Products; Catalysis; Lignans; Molecular Structure; Palladium; Podophyllotoxin; Stereoisomerism	2014
Synthesis and insecticidal activity of novel hydrazone compounds derived from a naturally occurring lignan podophyllotoxin against Mythimna separata (Walker). Bioorganic & medicinal chemistry letters, 2014, Jun-15, Volume: 24, Issue:12 Topics: Animals; Crystallography, X-Ray; Hydrazones; Insecticides; Larva; Lignans; Models, Molecular; Moths; Plant Roots; Podophyllotoxin	2014
Kinetics of glucosylated and non-glucosylated aryltetralin lignans in Linum hairy root cultures. Phytochemistry, 2015, Volume: 115 Topics: Drugs, Chinese Herbal; Flax; Glycosylation; Kinetics; Lignans; Molecular Structure; Plant Roots; Podophyllotoxin	2015
Purity Assessment of Aryltetralin Lactone Lignans by Quantitative 1H Nuclear Magnetic Resonance. Molecules (Basel, Switzerland), 2015, May-26, Volume: 20, Issue:6 Topics: Chromatography, High Pressure Liquid; Dinitrobenzenes; Drugs, Chinese Herbal; Lactones; Lignans; Podophyllotoxin; Proton Magnetic Resonance Spectroscopy; Reference Standards	2015
[Correlation research on contents of podophyllotoxin and total lignans in Sinopodophyllum hexandrum and ecological factors]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2015, Volume: 40, Issue:9 Topics: Berberidaceae; China; Chromatography, High Pressure Liquid; Climate; Drugs, Chinese Herbal; Ecosystem; Lignans; Podophyllotoxin; Soil; Temperature	2015
Structural and Biochemical Characterization of the Interaction of Tubulin with Potent Natural Analogues of Podophyllotoxin. Journal of natural products, 2016, 08-26, Volume: 79, Issue:8 Topics: Bursera; Cell Cycle; Colchicine; Humans; Lactones; Lignans; Microtubules; Molecular Structure; Podophyllotoxin; Protein Binding; Tubulin; Tubulin Modulators	2016
Cytotoxicity, Post-Treatment Recovery, and Selectivity Analysis of Naturally Occurring Podophyllotoxins from Bursera fagaroides var. fagaroides on Breast Cancer Cell Lines. Molecules (Basel, Switzerland), 2016, Aug-04, Volume: 21, Issue:8 Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Bursera; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; Lignans; MCF-7 Cells; Molecular Structure; Plant Extracts; Podophyllotoxin	2016
Investigation of the Lignan Content in Extracts from Linum, Callitris and Juniperus Species in Relation to Their In Vitro Antiproliferative Activities. Planta medica, 2017, Volume: 83, Issue:6 Topics: Antineoplastic Agents; Biosynthetic Pathways; Cell Line, Tumor; Cell Proliferation; Cupressaceae; Drug Synergism; Drugs, Chinese Herbal; Flax; Humans; Juniperus; Lignans; Molecular Structure; Plant Extracts; Podophyllotoxin	2017
Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin. Molecules (Basel, Switzerland), 2018, Nov-21, Volume: 23, Issue:11 Topics: Catalysis; Cyclization; Lactones; Lignans; Models, Molecular; Molecular Structure; Podophyllin; Podophyllotoxin	2018
Asymmetric Chemoenzymatic Synthesis of (-)-Podophyllotoxin and Related Aryltetralin Lignans. Angewandte Chemie (International ed. in English), 2019, 08-19, Volume: 58, Issue:34 Topics: Antineoplastic Agents, Phytogenic; Biological Products; Dioxygenases; Humans; Lignans; Molecular Structure; Podophyllotoxin; Tetrahydronaphthalenes	2019
Potential anti-neuroblastoma agents from Juniperus oblonga. Biochemical and biophysical research communications, 2019, 08-27, Volume: 516, Issue:3 Topics: Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Survival; Child, Preschool; Diterpenes; Drugs, Chinese Herbal; Furans; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Inhibitory Concentration 50; Juniperus; Lignans; Molecular Structure; N-Myc Proto-Oncogene Protein; Neuroblastoma; Phytotherapy; Plant Extracts; Podophyllotoxin; Tetrahydronaphthalenes	2019
Dereplication of podophyllotoxin and related cytotoxic lignans in Hyptis verticillata by ultra-high-performance liquid chromatography tandem mass spectrometry. Phytochemical analysis : PCA, 2020, Volume: 31, Issue:1 Topics: Chromatography, High Pressure Liquid; Hyptis; Lamiaceae; Lignans; Podophyllotoxin; Tandem Mass Spectrometry	2020
Identification and molecular characterization of the tubulin-podophyllotoxin-type lignans binding site on Giardia lamblia. Chemical biology & drug design, 2019, Volume: 94, Issue:6 Topics: Antiprotozoal Agents; Binding Sites; Giardia lamblia; Lignans; Molecular Docking Simulation; Podophyllotoxin; Protein Binding; Protozoan Proteins; Trophozoites; Tubulin	2019
Novel lignan-based compounds via click chemistry: paulownin isolation, structural modifications and cytotoxic activity evaluations. Natural product research, 2021, Volume: 35, Issue:21 Topics: Alkynes; Azides; Bridged-Ring Compounds; Catalysis; Click Chemistry; Copper; Cycloaddition Reaction; Lignans; Podophyllotoxin	2021
Deoxypodophyllotoxin, a Lignan from International journal of molecular sciences, 2020, Sep-18, Volume: 21, Issue:18 Topics: Antineoplastic Agents, Phytogenic; Apiaceae; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drugs, Chinese Herbal; ErbB Receptors; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Extracellular Signal-Regulated MAP Kinases; Humans; Lignans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species	2020
Assembly of Plant Enzymes in ACS synthetic biology, 2020, 11-20, Volume: 9, Issue:11 Topics: 4-Butyrolactone; Berberidaceae; Biotransformation; Cytochrome P-450 Enzyme System; Escherichia coli; Forsythia; Furans; Lignans; NADP; Oxidation-Reduction; Podophyllotoxin; Podophyllum peltatum	2020
Synthesis of (-)-deoxypodophyllotoxin and (-)-epipodophyllotoxin via a multi-enzyme cascade in E. coli. Microbial cell factories, 2021, Sep-20, Volume: 20, Issue:1 Topics: Biocatalysis; Biotransformation; Drugs, Chinese Herbal; Escherichia coli; Lignans; Podophyllotoxin	2021
Comprehensive study of Anthriscus sylvestris lignans. Phytochemistry, 2021, Volume: 192 Topics: Apiaceae; Lignans; Plant Extracts; Podophyllotoxin; Tandem Mass Spectrometry	2021
In Vitro Anti-Tubulin Activity on MCF10A Cell Line and In Silico Rigid/Semiflexible-Residues Docking, of Two Lignans from Bursera Fagaroides var. Fagaroides. Molecules (Basel, Switzerland), 2021, Oct-12, Volume: 26, Issue:20 Topics: Binding Sites; Bursera; Cell Line, Tumor; Computer Simulation; Humans; Lignans; Molecular Docking Simulation; Molecular Structure; Plant Extracts; Podophyllotoxin; Podophyllum; Tubulin	2021
Stereochemistry of the Benzylidene γ-Butyrolactone Dictates the Reductive Heck Cyclization Mode in the Asymmetric Synthesis of Aryltetralin Lignans: A Detailed Experimental and Theoretical Study. The Journal of organic chemistry, 2022, 03-18, Volume: 87, Issue:6 Topics: 4-Butyrolactone; Cyclization; Lignans; Models, Theoretical; Molecular Structure; Podophyllotoxin	2022
Aryltetralin lignans from Hyptis brachiata inhibiting T lymphocyte proliferation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 160 Topics: Cell Proliferation; Humans; Hyptis; Lamiaceae; Lignans; Podophyllotoxin	2023
Lignans from the Roots and Rhizomes of Molecules (Basel, Switzerland), 2023, Mar-24, Volume: 28, Issue:7 Topics: Antineoplastic Agents; Berberidaceae; Lignans; Molecular Structure; Plant Roots; Podophyllotoxin; Rhizome	2023
Methyl jasmonate redirects the dynamics of carbohydrates and amino acids toward the lignans accumulation in Linum album cells. Plant physiology and biochemistry : PPB, 2023, Volume: 198 Topics: Acetates; Amino Acids; Ammonia-Lyases; Carbohydrates; Cyclopentanes; Flax; Hydrogen Peroxide; Lignans; Oxylipins; Podophyllotoxin; Sugars	2023
Comprehensive RNA-Seq-based study and metabolite profiling to identify genes involved in podophyllotoxin biosynthesis in Linum album Kotschy ex Boiss. (Linaceae). Scientific reports, 2023, 06-07, Volume: 13, Issue:1 Topics: Flax; Lignans; Linaceae; Podophyllotoxin; RNA-Seq	2023
Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection. The Journal of biological chemistry, 2001, Apr-20, Volume: 276, Issue:16 Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Asteraceae; Base Sequence; Butylene Glycols; Cloning, Molecular; DNA, Complementary; Escherichia coli; Gene Library; Humans; Kinetics; Lignans; Molecular Sequence Data; Molecular Weight; NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases; Plants, Medicinal; Plants, Toxic; Podophyllum; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid	2001
Separation and determination of podophyllum lignans by micellar electrokinetic chromatography. Journal of chromatography. A, 2001, Aug-31, Volume: 928, Issue:1 Topics: Chromatography, Micellar Electrokinetic Capillary; Hydrogen-Ion Concentration; Lignans; Podophyllum; Reproducibility of Results; Sodium Dodecyl Sulfate	2001
New lignan glycosides from Chinese medicinal plant, Sinopodophillum emodi. Chemical & pharmaceutical bulletin, 2003, Volume: 51, Issue:3 Topics: Drugs, Chinese Herbal; Glycosides; Lignans; Plant Roots; Podophyllum; Rhizome	2003
Resin sikkimensis. I. Sikkimotoxin: a lactone from podophyllum sikkimensis r. chatterjee et mukerjee. Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1952, Volume: 41, Issue:8 Topics: Humans; Lactones; Lignans; Podophyllin; Podophyllum; Resins, Plant; Tetrahydronaphthalenes	1952
Effect of podophyllin lignans on mast cell morphology in rat peritoneal fluid. The American journal of physiology, 1961, Volume: 200 Topics: Animals; Ascitic Fluid; Lignans; Mast Cells; Podophyllin; Podophyllum; Rats	1961
[ON SOME PODOPHYLLUM LIGNANS CONTAINING NITROGEN]. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, 1964, Volume: 297 Topics: Chemistry Techniques, Analytical; Lignans; Nitrogen; Podophyllum; Research	1964
[NOTICE ON THE PREPARATION OF TETRAHYDROPYRANYL DERIVATIVES OF SOME PODOPHYLLUM LIGNANS]. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, 1964, Volume: 297 Topics: Chemistry, Pharmaceutical; Lignans; Podophyllin; Podophyllum; Pyrans; Research	1964
Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans. The Journal of biological chemistry, 2005, Apr-01, Volume: 280, Issue:13 Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Catalysis; Catalytic Domain; Crystallography, X-Ray; Fourier Analysis; Hydrogen Bonding; Light; Lignans; Models, Chemical; Models, Molecular; Models, Statistical; Molecular Sequence Data; NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases; Oxidoreductases; Plant Extracts; Plant Physiological Phenomena; Podophyllum; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Scattering, Radiation; Sequence Homology, Amino Acid; Substrate Specificity; Tyrosine	2005
Podophyllum hexandrum as a potential botanical supplement for the medical management of nuclear and radiological emergencies (NREs) and free radical-mediated ailments: leads from in vitro/in vivo radioprotective efficacy evaluation. Journal of dietary supplements, 2010, Volume: 7, Issue:1 Topics: Animals; Dietary Supplements; DNA; DNA Damage; Emergencies; Erythrocytes; Flavonoids; Free Radical Scavengers; Free Radicals; Gamma Rays; Humans; Lignans; Lipid Peroxidation; Malondialdehyde; Mice; Mice, Inbred Strains; Phytotherapy; Plant Extracts; Podophyllum; Radiation Injuries; Radiation-Protective Agents; Radioactive Hazard Release; Reactive Nitrogen Species; Reactive Oxygen Species; Treatment Outcome	2010
RP-HPLC method using one marker for quantification of four podophyllum lignans in medicinal plants. Journal of chromatographic science, 2014, Volume: 52, Issue:6 Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Lignans; Plants, Medicinal; Podophyllum; Reproducibility of Results	2014
Toxicity and Larvicidal Activity of Podophyllum-Based Lignans Against Aedes aegypti (Diptera: Culicidae). Journal of medical entomology, 2017, Volume: 54, Issue:1 Topics: Aedes; Animals; Insecticides; Larva; Lignans; Mosquito Control; Plant Extracts; Plant Roots; Podophyllum; Rhizome	2017
Combined In Vitro Studies and in Silico Target Fishing for the Evaluation of the Biological Activities of Molecules (Basel, Switzerland), 2018, Dec-13, Volume: 23, Issue:12 Topics: Anti-Bacterial Agents; Antioxidants; Berberidaceae; Cell Death; Cell Line; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Computer Simulation; Humans; Lignans; Microbial Sensitivity Tests; Plant Extracts; Podophyllum; Reproducibility of Results; ROC Curve; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2018
Dirigent Proteins Guide Asymmetric Heterocoupling for the Synthesis of Complex Natural Product Analogues. Journal of the American Chemical Society, 2021, 04-07, Volume: 143, Issue:13 Topics: Biological Products; Lignans; Oxidation-Reduction; Phenols; Plant Proteins; Podophyllum; Proteins; Stereoisomerism	2021