Page last updated: 2024-08-21

podophyllotoxin and fosbretabulin

podophyllotoxin has been researched along with fosbretabulin in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.78)	18.7374
1990's	10 (27.78)	18.2507
2000's	16 (44.44)	29.6817
2010's	6 (16.67)	24.3611
2020's	3 (8.33)	2.80

Authors

Authors	Studies
Chakraborti, AK; Cushman, M; Gopal, D; Hamel, E; Lin, CM; Nagarathnam, D	1
Hamel, E; Kuo, SC; Lee, KH; Li, L; Lin, CM; Mauger, A; Wang, HK; Wu, TS	1
Hamel, E; Kuo, SC; Lednicer, D; Lee, KH; Li, L; Lin, CM; Wang, HK; Wu, TS	1
Chang, JJ; Hamel, E; Juang, JP; Kuo, SC; Lednicer, D; Lee, HZ; Lin, CM; Lin, YT; Paull, KD; Wu, TS	1
Chen, K; Hamel, E; Hsieh, MC; Kuo, SC; Lee, KH; Lin, CM; Mauger, A	2
Bastow, KF; Hackl, T; Hamel, E; Kuo, SC; Lee, KH; Tachibana, Y; Xia, P; Xia, Y; Yang, ZY	1
Bai, R; Bounds, AD; Dingeman, KM; Hamel, E; Mocharla, VP; Pettit, GR; Pinney, KG	1
Bastow, KF; Hamel, E; Kuo, SC; Lee, KH; Mauger, A; Narayanan, VL; Tachibana, Y; Zhang, SX	1
Bastow, K; Hamel, E; Hour, MJ; Huang, LJ; Kuo, SC; Lee, KH; Nakanishi, Y; Xia, Y	1
Bastow, KF; Hackl, T; Hamel, E; Hour, MJ; Kuo, SC; Lee, HK; Nakanishi, Y; Namrpoothiri, P; Xia, P; Xia, Y; Yang, ZY	1
Hackl, T; Hamel, E; Lee, KH; Mauger, A; Wu, JH; Xia, P; Xia, Y; Yang, ZY	1
Cushman, M; Hamel, E; Lee, DJ; Mu, F; Pryor, DE	1
Burger, AM; Camacho Gomez, JA; Düssmann, H; Günther, EG; Hirano, T; Ishii, Y; Prehn, JH; Prinz, H; Schmidt, P; Stoiber, T; Umezawa, K; Unger, E	1
Dalrymple, S; Hallur, G; Hamel, E; Hidalgo, M; Isaacs, JT; Jimeno, A; Jung, MK; Khan, SR; Sukumar, S; Zhu, T	1
Baraldi, PG; Borgatti, M; Fruttarolo, F; Gambari, R; Hamel, E; Jung, MK; Pavani, MG; Piccagli, L; Preti, D; Romagnoli, R; Tabrizi, MA	1
Boykin, DW; Hu, L; Jiang, JD; Li, Y; Li, ZR; Ling, YH; Qu, J	1
Boykin, DW; Hu, L; Jiang, JD; Li, ZR; Wang, YM; Wu, Y	1
Boykin, DW; Hu, L; Jiang, JD; Jin, J; Li, Y; Li, ZR; Qu, J	1
Cafici, L; Canonico, PL; Galli, U; Genazzani, AA; Imperio, D; Pagliai, F; Pirali, T; Sorba, G; Tron, GC	1
Boykin, DW; Hu, L; Jiang, JD; Li, JN; Li, ZR; Qu, J	1
Balasubramanian, R; Fecik, RA; Raghavan, B; Sackett, DL; Steele, JC	1
Janaki Ramaiah, M; Kamal, A; Kumar, BA; Lavanya, A; Mallareddy, A; Pal-Bhadra, M; Pushpavalli, SN; Raju, P; Sarma, P; Suresh, P; Vinay Gopal, J	1
Das, A; Dhoke, NR; Duscharla, D; Ramasatyaveni, G; Shareef, MA; Srivastava, AK; Ummanni, R	1
Bhoyar, AS; Chaudhary, V; Dhaked, HP; Guchhait, SK; Panda, D; Venghateri, JB	1
Chen, X; Hu, L; Liu, Y; Sun, L; Wu, Y	1
Diao, Q; Gao, F; Gao, M; Sun, Z; Wang, P; Xiao, J	1
Kislyi, VP; Maksimenko, AS; Semenov, VV; Semenova, MN; Stroylov, VS; Svitanko, IV	1
Chen, TT; Kong, LY; Leng, JF; Yan, XY; Yin, Y; Zhao, YJ	1
Hamel, E; Ho, HH; Lin, CM; Pettit, GR	1
D'Amato, RJ; Flynn, E; Hamel, E; Lin, CM	1
Gupta, MM; Khanuja, SP; Kumar, JK; Negi, AS; Srivastava, V	1
Burnett, JC; Day, BW; Gussio, R; Hamel, E; Hermone, AR; McGrath, C; Nguyen, TL; Wipf, P; Zaharevitz, DW	1
Chen, P; Hu, Z; Lewis, A; Li, C; Li, PK; Pandit, B; Rich, W; Sackett, DL; Schaefer, K; Sun, Y	1
Akhmanova, A; Doodhi, H; Kapitein, LC; Katrukha, EA; Meijering, E; Mohan, R; Smal, I; Steinmetz, MO	1
Defant, A; Mancini, I	1

Reviews

2 review(s) available for podophyllotoxin and fosbretabulin

Article	Year
Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020). European journal of medicinal chemistry, 2020, Dec-15, Volume: 208 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Molecular Structure; Podophyllotoxin; Stereoisomerism; Structure-Activity Relationship	2020
Plant-based anticancer molecules: a chemical and biological profile of some important leads. Bioorganic & medicinal chemistry, 2005, Nov-01, Volume: 13, Issue:21 Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Humans; Paclitaxel; Podophyllotoxin; Stilbenes	2005

Article

Year

Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020).

European journal of medicinal chemistry, 2020, Dec-15, Volume: 208

Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Molecular Structure; Podophyllotoxin; Stereoisomerism; Structure-Activity Relationship

2020

Plant-based anticancer molecules: a chemical and biological profile of some important leads.

Bioorganic & medicinal chemistry, 2005, Nov-01, Volume: 13, Issue:21

Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Humans; Paclitaxel; Podophyllotoxin; Stilbenes

2005

Other Studies

34 other study(ies) available for podophyllotoxin and fosbretabulin

Article	Year
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. Journal of medicinal chemistry, 1991, Volume: 34, Issue:8 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Chemical Phenomena; Chemistry; Colchicine; Colonic Neoplasms; Humans; Lung Neoplasms; Melanoma; Molecular Structure; Polymers; Stilbenes; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	1991
Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents. Journal of medicinal chemistry, 1994, Sep-30, Volume: 37, Issue:20 Topics: Animals; Antineoplastic Agents; Cattle; Colchicine; Humans; Microtubules; Molecular Structure; Polymers; Pyrrolidines; Quinolones; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	1994
Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 1994, Apr-15, Volume: 37, Issue:8 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Small Cell; Cattle; Cell Division; Central Nervous System Neoplasms; Colonic Neoplasms; Female; Humans; Leukemia; Lung Neoplasms; Molecular Structure; Polymers; Quinolones; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	1994
Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin. Journal of medicinal chemistry, 1993, Apr-30, Volume: 36, Issue:9 Topics: Animals; Antineoplastic Agents; Humans; Intestinal Neoplasms; Leukemia L1210; Leukemia P388; Lung Neoplasms; Melanoma; Mice; Molecular Structure; Nasopharyngeal Neoplasms; Quinolines; Quinolones; Software; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	1993
Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 1997, Jul-04, Volume: 40, Issue:14 Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Screening Assays, Antitumor; Female; Humans; Indicators and Reagents; KB Cells; Magnetic Resonance Spectroscopy; Male; Mice; Naphthyridines; Software; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured	1997
Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization. Journal of medicinal chemistry, 1997, Sep-12, Volume: 40, Issue:19 Topics: Antineoplastic Agents; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Female; Humans; Indicators and Reagents; Macromolecular Substances; Male; Molecular Structure; Naphthyridines; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured	1997
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents. Journal of medicinal chemistry, 1998, Mar-26, Volume: 41, Issue:7 Topics: Antibiotics, Antineoplastic; Humans; Quinolones; Tubulin; Tumor Cells, Cultured	1998
A new anti-tubulin agent containing the benzo[b]thiophene ring system. Bioorganic & medicinal chemistry letters, 1999, Apr-19, Volume: 9, Issue:8 Topics: Dose-Response Relationship, Drug; Humans; Hydrolysis; Thiophenes; Time Factors; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	1999
Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 1999, Oct-07, Volume: 42, Issue:20 Topics: Antineoplastic Agents; Biopolymers; Colchicine; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Models, Molecular; Naphthyridines; Structure-Activity Relationship; Thiophenes; Tubulin; Tumor Cells, Cultured	1999
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 2000, Nov-16, Volume: 43, Issue:23 Topics: Antineoplastic Agents; Biopolymers; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Pyrrolidines; Quinazolines; Quinazolinones; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	2000
Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones. Bioorganic & medicinal chemistry letters, 2001, May-07, Volume: 11, Issue:9 Topics: Anti-HIV Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; HIV Infections; Humans; Lymphocytes; Quinazolines; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured	2001
Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents. Journal of medicinal chemistry, 2001, Nov-08, Volume: 44, Issue:23 Topics: Antineoplastic Agents; Biopolymers; Drug Screening Assays, Antitumor; Humans; Mitosis; Pyrroles; Quinolones; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured	2001
Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Antineoplastic Agents; Biopolymers; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Phenols; Salicylamides; Stilbenes; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured	2003
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 2003, Jul-17, Volume: 46, Issue:15 Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Biopolymers; Blotting, Western; Cell Cycle; Cell Survival; Drug Screening Assays, Antitumor; Humans; K562 Cells; Microscopy, Electron; Structure-Activity Relationship; Tubulin	2003
Benzoylphenylurea sulfur analogues with potent antitumor activity. Journal of medicinal chemistry, 2006, Apr-06, Volume: 49, Issue:7 Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Phenylurea Compounds; Pyrimidines; Structure-Activity Relationship; Tubulin Modulators	2006
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents. Journal of medicinal chemistry, 2006, Jun-29, Volume: 49, Issue:13 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzoates; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Screening Assays, Antitumor; Humans; Mice; Models, Molecular; Protein Binding; Structure-Activity Relationship; Thiophenes; Tubulin; Tubulin Modulators	2006
Synthesis and structure-activity relationships of carbazole sulfonamides as a novel class of antimitotic agents against solid tumors. Journal of medicinal chemistry, 2006, Oct-19, Volume: 49, Issue:21 Topics: Animals; Antimitotic Agents; Apoptosis; Breast Neoplasms; Carbazoles; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Structure-Activity Relationship; Sulfonamides; Transplantation, Heterologous; Tumor Suppressor Protein p53	2006
Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents. Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5 Topics: Antineoplastic Agents; Carbazoles; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Pyridines; Pyrimidines; Structure-Activity Relationship; Sulfonamides	2007
Novel potent antimitotic heterocyclic ketones: synthesis, antiproliferative activity, and structure-activity relationships. Bioorganic & medicinal chemistry letters, 2007, Jul-01, Volume: 17, Issue:13 Topics: Antimitotic Agents; Antineoplastic Agents; Carbazoles; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Ketones; Models, Chemical; Structure-Activity Relationship; Sulfonamides; Tubulin	2007
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry. Bioorganic & medicinal chemistry, 2007, Nov-01, Volume: 15, Issue:21 Topics: 4-Butyrolactone; Antineoplastic Agents; Catalysis; Cell Line, Tumor; Humans; Lactones; Lignans; Molecular Conformation; Podophyllotoxin; Ruthenium; Triazoles; Tubulin	2007
3-(2'-Bromopropionylamino)-benzamides as novel S-phase arrest agents. Bioorganic & medicinal chemistry letters, 2007, Dec-15, Volume: 17, Issue:24 Topics: Animals; Benzamides; Brain; Bromides; Cattle; Cell Line, Tumor; Humans; Leukemia; Molecular Structure; Propylamines; S Phase; Structure-Activity Relationship; Tubulin	2007
Cytotoxic simplified tubulysin analogues. Journal of medicinal chemistry, 2008, Mar-27, Volume: 51, Issue:6 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Oligopeptides; Structure-Activity Relationship; Time Factors	2008
Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents. Bioorganic & medicinal chemistry, 2011, Aug-01, Volume: 19, Issue:15 Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Comet Assay; DNA; DNA Damage; Drug Screening Assays, Antitumor; Etoposide; Humans; Neoplasms; Podophyllotoxin	2011
Investigation of podophyllotoxin esters as potential anticancer agents: synthesis, biological studies and tubulin inhibition properties. European journal of medicinal chemistry, 2015, Jan-07, Volume: 89 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Esters; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2015
Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety. Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7 Topics: Apoptosis; Bibenzyls; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; Imidazoles; Microtubules; Mitosis; Molecular Structure; Prodrugs; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	2016
Novel carbazole sulfonamide derivatives of antitumor agent: Synthesis, antiproliferative activity and aqueous solubility. Bioorganic & medicinal chemistry letters, 2017, 01-15, Volume: 27, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Carbazoles; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Solubility; Structure-Activity Relationship; Sulfonamides; Water	2017
Computational modeling and target synthesis of monomethoxy-substituted o-diphenylisoxazoles with unexpectedly high antimitotic microtubule destabilizing activity. Bioorganic & medicinal chemistry letters, 2020, 12-01, Volume: 30, Issue:23 Topics: Animals; Binding Sites; Cell Line, Tumor; Embryo, Nonmammalian; Humans; Isoxazoles; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Sea Urchins; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2020
Design, synthesis, and biological evaluation of novel diphenylamine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Colchicine; Diphenylamine; Drug Screening Assays, Antitumor; Humans; Mice; Molecular Docking Simulation; Poly(ADP-ribose) Polymerase Inhibitors; Polymerization; Tubulin; Tubulin Modulators	2022
Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin. Biochemistry, 1989, Aug-22, Volume: 28, Issue:17 Topics: Animals; Bibenzyls; Binding Sites; Brain; Cattle; Colchicine; Guanosine Triphosphate; Kinetics; Macromolecular Substances; Mitosis; Models, Structural; Plant Extracts; Podophyllotoxin; Protein Binding; Stilbenes; Tropolone; Tubulin	1989
Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin polymers. Biochemistry, 1996, Jan-30, Volume: 35, Issue:4 Topics: 2-Methoxyestradiol; Binding Sites; Colchicine; Estradiol; Glutamates; Kinetics; Microtubule-Associated Proteins; Microtubules; Podophyllotoxin; Polymers; Stilbenes; Tubulin	1996
A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. Journal of medicinal chemistry, 2005, Sep-22, Volume: 48, Issue:19 Topics: 2-Methoxyestradiol; 4-Butyrolactone; Aminophenols; Binding Sites; Chalcone; Colchicine; Cyclopropanes; Estradiol; Indans; Lignans; Models, Molecular; Molecular Structure; Nocodazole; Podophyllotoxin; Protein Binding; Stilbenes; Structure-Activity Relationship; Sulfonamides; Thiazoles; Tubulin; Tubulin Modulators	2005
Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416. Bioorganic & medicinal chemistry, 2006, Oct-01, Volume: 14, Issue:19 Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; DNA, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Indoles; Isomerism; Magnetic Resonance Spectroscopy; Molecular Conformation; Podophyllotoxin; Pyrroles; Stilbenes; Structure-Activity Relationship; Tubulin	2006
End-binding proteins sensitize microtubules to the action of microtubule-targeting agents. Proceedings of the National Academy of Sciences of the United States of America, 2013, May-28, Volume: 110, Issue:22 Topics: Bridged Bicyclo Compounds, Heterocyclic; Cellular Senescence; Colchicine; Depsipeptides; Green Fluorescent Proteins; HeLa Cells; Humans; Lactones; Microscopy, Fluorescence; Microtubule-Associated Proteins; Microtubules; Models, Biological; Paclitaxel; Podophyllotoxin; Statistics, Nonparametric; Stilbenes; Tubulin Modulators; Vinblastine	2013
Design, Synthesis and Cancer Cell Growth Inhibition Evaluation of New Aminoquinone Hybrid Molecules. Molecules (Basel, Switzerland), 2019, Jun-14, Volume: 24, Issue:12 Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Naphthoquinones; Neoplasms; Podophyllotoxin; Pyridines; Quinolines; rho-Associated Kinases; Stilbenes; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tubulin; Tubulin Modulators	2019