podophyllotoxin has been researched along with etoposide in 567 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 388 (68.43) | 18.7374 |
| 1990's | 70 (12.35) | 18.2507 |
| 2000's | 37 (6.53) | 29.6817 |
| 2010's | 64 (11.29) | 24.3611 |
| 2020's | 8 (1.41) | 2.80 |
| Authors | Studies |
|---|---|
| Harkes, M; Homan, B; Malingré, TM; Pras, N; Van Uden, W; Wichers, HJ; Woerdenbag, HJ | 1 |
| Chu, DT; Clement, JJ; Klein, LL; McDonald, EJ; Plattner, JJ; Yeung, CM | 1 |
| Hansch, C; Khwaja, TA; Selassie, CD | 1 |
| Jurd, L; Narayanan, VL; Paull, KD | 1 |
| Cheng, YC; Han, FS; Irie, H; Lee, KH; Liu, ZC; Tani, S; Thurston, LS | 1 |
| Feringa, BL; Jansen, JF; Kellogg, RM; Konings, AW; Middel, O; Pras, N; van Oeveren, A; van Uden, W; Woerdenbag, HJ | 1 |
| Bastow, KF; Brossi, A; Guan, J; Hamel, E; Lee, KH; Tachibana, Y; Zhu, XK | 1 |
| Daley, L; Demerseman, P; Etiévant, C; Guminski, Y; Hill, BT; Imbert, T; Kruczynski, A; Monneret, C | 1 |
| Charlton, JL | 1 |
| Babu, JM; Deevi, DS; Rao, CV; Renuka, B; Sagar, PS; Subrahmanyam, D; Vyas, K | 1 |
| Deevi, DS; Kumar, GS; Renuka, B; Subrahmanyam, D; Vandana, V | 1 |
| Bastow, KF; Huang, ES; Lee, KH; Tachibana, Y; VanVliet, DS | 1 |
| Abad, A; de Pascual-Teresa, B; del Olmo, E; López-Pérez, JL; San Feliciano, A | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Kornienko, A; Magedov, IV; Manpadi, M; Przheval'skii, NM; Rogelj, S; Rozhkova, E; Shors, ST; Steelant, WF; Van slambrouck, S | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Kornienko, A; Magedov, IV; Manpadi, M; Przheval'skii, NM; Rogelj, S; Rozhkova, E; Slambrouck, SV; Steelant, WF | 1 |
| Agrawal, SK; Bhat, BA; Kumar, HM; Qazi, GN; Reddy, PB; Saxena, AK | 1 |
| Imai, T; Kobayashi, S; Kuramochi, K; Saitoh, T; Sakaguchi, K; Sugawara, F; Takata, K; Takehara, M | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Lee, KH | 1 |
| Jain, N; Kalivendi, SV; Kamal, A; Kumar, BA; Mallareddy, A; Raju, P; Reddy, PV; Shaik, TB; Suresh, P; Tamboli, JR | 1 |
| Chen, H; Hua, HM; Li, ZL; Liu, XQ; Sun, YJ; Zhou, W | 1 |
| Janaki Ramaiah, M; Kamal, A; Kumar, BA; Lavanya, A; Mallareddy, A; Pal-Bhadra, M; Pushpavalli, SN; Raju, P; Sarma, P; Suresh, P; Vinay Gopal, J | 1 |
| Chen, H; Chen, L; Li, T; Liu, D; Liu, J; Liu, Y; Lu, Y; Tang, X; Wang, X; Zhang, S; Zhao, M; Zuo, S | 1 |
| Firgang, SI; Fuchs, F; Kiselyov, AS; Konyushkin, LD; Kuznetsov, SA; Lantow, M; Malyshev, OR; Philchenkov, AA; Raihstat, MM; Semenov, RV; Semenov, VV; Semenova, MN; Stielow, A; Tsyganov, DV; Zavelevich, MP; Zefirov, NS | 1 |
| Kamal, A; Lakshma Nayak, V; Mallareddy, A; Ramakrishna, S; Sankara Rao, N; Shaik, TB; Shetti, RV; Suresh, P; Tamboli, JR; Vishnuvardhan, MV | 1 |
| Chen, SW; Ding, YL; Huang, WT; Hui, L; Liu, J; Liu, JF | 1 |
| Chen, X; Hu, K; Ren, J; Wu, L; Xin, WQ | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Adil, SF; Kamal, A; Nayak, VL; Ramakrishna, S; Tamboli, JR; Vishnuvardhan, MV | 2 |
| Chen, SW; Hui, L; Liu, JF; Sang, CY; Xu, XH; Yang, X; Zhang, JB; Zhang, LL | 1 |
| Ganga Reddy, V; Jain, N; Kamal, A; Paidakula, S; Polepalli, S; Shankaraiah, N; Srinivasa Reddy, T; Srinivasulu, V | 1 |
| Cao, B; Chen, H; Cheng, WH; Niu, C; Shang, H; Tian, DL; Zhang, LM; Zhang, S; Zhang, ZH; Zou, ZM | 1 |
| Jain, N; Kamal, A; Polepalli, S; Reddy, VG; Shalini, N; Shankaraiah, N; Srinivasa Reddy, T; Subba Rao, AV | 1 |
| Das, A; Dhoke, NR; Duscharla, D; Ramasatyaveni, G; Shareef, MA; Srivastava, AK; Ummanni, R | 1 |
| Amula, SB; Jeengar, MK; Kamal, A; Kumar, NP; Naidu, VG; Nekkanti, S; Reddy, TS; Shankaraiah, N | 1 |
| Chen, F; Chen, Y; Wang, J; Zhang, L; Zhang, Z | 1 |
| Jones, AT; Kandil, S; Kariuki, BM; McGuigan, C; Westwell, AD; Wymant, JM | 1 |
| Bahulayan, AK; Kabeer, FA; Madhusoodhanan, AR; Nair, MS; Prakasan, N; Prathapan, R; Rajalekshmi, DS; Varughese, S | 1 |
| Han, HW; Hu, C; Lu, GH; Qi, JL; Qiu, HY; Sun, WX; Wang, XM; Yang, RW; Yang, YH | 1 |
| Chen, F; Chen, Y; Lin, Y; Wang, J; Zhang, L; Zhang, Z | 1 |
| Han, HW; Ji, YJ; Lin, HY; Lu, GH; Qi, JL; Sun, WX; Wan, Y; Wang, XM; Yang, YH | 1 |
| Ajitha, A; Alarifi, A; Kamal, A; Kavitha, B; Nagesh, N; Nayak, VL; Nekkanti, S; Sathish, M; Shankaraiah, N; Tangella, Y | 1 |
| Akunuri, R; Bhargava, SK; Bonam, SR; Kamal, A; Kumar, HMS; Naidu, VGM; Nayak, VL; Reddy, TS; Reddy, VG; Srihari, P | 1 |
| Chen, Y; Long, L; Wang, J; Xu, Y; Zhang, L | 1 |
| Abdel Wahab, AHA; Abdelhameid, MK; Ashmawy, AM; El-Deen, IM; Mohamed, KO; Zaki, I | 1 |
| He, L; Tang, YJ; Xiang, TL; Zhao, W | 1 |
| Liu, Y; Xu, Z; Zhao, SJ | 1 |
| Chanda, D; Dudi, RK; Fatima, K; Iqbal, H; Khan, F; Kumar, Y; Luqman, S; Mondhe, DM; Negi, AS; Shanker, K; Tabassum, M; Verma, AK | 1 |
| Diao, Q; Gao, F; Gao, M; Sun, Z; Wang, P; Xiao, J | 1 |
| Barton, CE; Bradley, AM; Deweese, JE; Kumar, P; Mercer, SL; Murphy, MB | 1 |
| Carr, DT; Eagan, RT; Frytak, S; Lee, RE; Rubin, J | 1 |
| Bagshawe, KD; Newlands, ES | 3 |
| Grieder, A; Maurer, R; Stähelin, H | 1 |
| Brunner, KW; Cavalli, F; Sonntag, RW | 1 |
| Beckmann, C; Flury, R; Frei, P; Holdener, E; Jungi, WF; Senn, HJ | 1 |
| Dombernowsky, P; Hansen, HH; Hansen, M; Hirsch, F | 1 |
| Brunner, KW; Cavalli, F; Gerber, A; Ryssel, HJ; Sonntag, RW; Tschopp, L | 1 |
| Ferguson, A; Hewitson, R; Levin, W; Sealy, R; Tucker, RD; Van Wyk, C | 1 |
| Fontana, JA | 1 |
| Bunn, PA; Ihde, DC; Radice, PA | 1 |
| Gétaz, EP; Staples, WG | 1 |
| Henney, JE; Muggia, FM; Rozencweig, M; Von Hoff, DD | 1 |
| Brunner, KW; Cavalli, F; Jungi, F; Senn, HJ; Sonntag, RW | 1 |
| Hartmann, D; Obrecht, JP; Stalder, GA | 1 |
| Hansen, HH; Lau, ME; Nissen, NI; Pedersen, H | 1 |
| Bauer, M; Bennett, JM; Creech, R; Hahn, RG; Wampler, G; Wolter, J | 1 |
| Crooke, ST; Issell, BF | 1 |
| Arnold, AM | 1 |
| Crooke, ST; Gutierrez, ML | 1 |
| Creagan, ET; Eagan, RT; Fleming, TR; Frytak, S; Ingle, JN; Kvols, LK; Rubin, J | 1 |
| Illiger, HJ; Labedzki, L | 1 |
| Jungi, WF; Mayr, AC; Schmieder, HA; Senn, HJ | 1 |
| Carbone, PP; Douglass, HO; Evans, JT; Lavin, PT; Mittelman, A | 1 |
| Kreis, W; Soricelli, A | 1 |
| Brunner, KW; Cavalli, F; Ryssel, HJ; Sonntag, RW | 2 |
| Decker, DG; Edmonson, JH; Jorgensen, EO; Malkasian, GD; Webb, MJ | 1 |
| Al-Sarraf, M; Cecil, JW; Coltman, CA; Groppe, CW; Quagliana, JM; Thigpen, T | 1 |
| Creagan, ET; Eagan, RT; Frytak, S; Ingle, JN; Kvols, LK; McMachon, RT; Rubin, J | 1 |
| Allen, LM | 2 |
| Allen, LM; Creaven, PJ; Pelsor, FR | 1 |
| Brewer, CF; Gensler, WJ; Horwitz, SB; Loike, JD; Sternlicht, H | 1 |
| Coulter, D; Kalish, R; Valeriote, FA; Vietti, TJ | 1 |
| Allen, L | 1 |
| Dubovsky, D; Jacobs, P; Kernoff, L | 1 |
| Agusti, A; Estape, J; Lloret, JS; Milla, A; Palacin, A; Soriano, E | 1 |
| Clink, HM; Gerken, ME; McElwain, TJ; Smith, IE | 1 |
| Hahn, RG; Moertel, CG; Perry, MC; Reitemeier, RJ; Schutt, AJ | 1 |
| Brunner, KW; Cavalli, F; Hasler, E; Martin, J; Ryssel, HJ; Sonntag, RW; Tschopp, L | 1 |
| Barouh, M; Carpentier, Y; Cattan, A; Cattan, E; Pourny, C | 2 |
| Dombernowsky, P; Nissen, NI | 1 |
| Stähelin, H | 1 |
| Horwitz, SB; Loike, JD | 2 |
| Dombernowsky, P; Hansen, HH; Larsen, V; Nissen, NI | 1 |
| Ahmann, DL; Bisel, HF; Eagan, RT | 1 |
| Barlogie, B; Drewinko, B | 1 |
| Ahmann, DL; Bisel, HF; Edmonson, JH; Frytak, S; Hahn, RG; O'Connell, MJ | 1 |
| Ahmann, DL; Bisel, HF; Eagan, RT; Edmonson, JH; Frytak, S; Hahn, RG; O'Connell, MJ | 1 |
| Brunner, KW; Cavalli, F; Sonntag, R | 1 |
| Alberto, P; Cavalli, F; Sauter, C; Senn, HJ | 1 |
| Allen, LM; Creaven, PJ | 1 |
| Avery, T; Rivera, G; Roberts, DW | 1 |
| Cheng, YC; Hu, H; Lee, KH; Liu, SY; Wang, ZQ | 1 |
| Chen, HX; Cheng, YC; Hu, H; Lee, KH; Wang, ZQ | 1 |
| Barley, LR; Chang, JY; Cheng, YC; Dethlefsen, LA; Zhou, BS | 1 |
| Kolonias, D; Lampidis, TJ; Rubin, RW; Savaraj, N | 1 |
| Adam, M; Baruchel, A; Brice, P; Dombret, H; Gisselbrecht, C; Lepage, E; Marolleau, JP; Miclea, JM; Sitthy, X | 1 |
| He, XQ; Li, JX; Tian, X; Zhang, PY | 1 |
| Kobayashi, K; Ratain, MJ | 2 |
| Miyazaki, I; Ohyama, S; Sasaki, T; Tanaka, M; Tsugawa, K; Yonemura, Y | 1 |
| Imakura, Y; Lee, KH; Miki, T; Sakurai, H; Shibuya, M | 1 |
| Derry, WB; Gupta, RS; Pamidi, CC | 1 |
| Coldman, AJ; Klasa, RJ; Murray, N | 1 |
| Chang, JY; Cheng, YC; Han, FS; Lee, KH; Liu, SY; Wang, ZQ | 1 |
| Behm, FG; Evans, WE; Hancock, ML; Head, DR; Mahmoud, MH; Pui, CH; Raimondi, SC; Ribeiro, RC; Rivera, GK; Sandlund, JT | 1 |
| Stähelin, HF; von Wartburg, A | 1 |
| Bugat, R; Canal, P; Chatelut, E; Chevreau, C; de Forni, M; Houin, G; Johnson, NP; Plusquellec, Y; Roche, H | 1 |
| Endo, Y; Kimura, H; Kosaka, T; Miyazaki, I; Ohyama, S; Sasaki, T; Tanaka, M; Tugawa, K; Yonemura, Y | 1 |
| Chen, YZ; Jia, ZP; Li, JX; Liang, ZD; Tian, X; Wang, YG; Zhang, PY | 1 |
| Gupta, R | 1 |
| Kiue, A; Kohno, K; Kuwano, M; Matsuo, K; Sato, S; Takano, H | 1 |
| Björkholm, M | 1 |
| D'Incalci, M; Figoli, F; Montaldo, PG; Sorio, R; Tirelli, U; Zanette, ML; Zucchetti, M | 1 |
| Huang, L; White, JC; Wright, SE | 1 |
| Hines, LH; White, JC; Wright, SE | 1 |
| Iwabuchi, M; Takahashi, K | 1 |
| Gorin, NC | 1 |
| Babaya, K; Hirao, Y; Kubota, K; Natsume, O; Okajima, E; Ozono, S; Tsumatani, K; Yoshie, T | 1 |
| Pizzocaro, G | 1 |
| Blazka, ME; Henner, WD | 1 |
| Boven, E; De Pauw, M; Harris, A; Jones, W; Kaye, SB; Sleijfer, D; Splinter, T; Stoter, G; Ten Bokkel Huinink, W; Van Oosterom, A | 1 |
| Bijma, AT; Dijksman, JA; Herscheid, JD; Visser, GW | 1 |
| Denyer, SP; Dewick, PM; Figgitt, DP; Jackson, DE; Williams, P | 1 |
| Cheng, YC; Haruna, M; Hwang, BD; Imakura, Y; Lee, KH; Liu, SY | 1 |
| Lönn, S; Lönn, U; Nylen, U; Winblad, G | 1 |
| Ellis, AL; Gewirtz, DA; Povirk, LF; Randolph, JK; Swerdlow, PS; Yalowich, JC; Yanovich, S | 1 |
| Martin, J; Nunn, AJ; Siddall, SJ | 1 |
| Newlands, ES | 1 |
| Kinouchi, T; Kotake, T; Kuroda, M; Maeda, O; Miki, T; Saiki, S; Tomooka, Y; Usami, M; Yoshimura, K | 1 |
| Bult, A; Holthuis, JJ; van Bennekom, WP; van der Horst, FA; van Opstal, MA | 1 |
| Liang, ZD; Mao, XJ; Tian, XA; Wang, JZ; Zhang, PY | 1 |
| Stähelin, H; von Wartburg, A | 1 |
| McVie, G; Muggia, FM | 1 |
| Beerman, TA; Sigmund, RD; Woynarowski, JM | 1 |
| Chow, KC; Macdonald, TL; Ross, WE | 1 |
| Berendsen, HH; Haaxma-Reiche, H; Postmus, PE | 1 |
| Yalowich, JC | 1 |
| Danigel, H; Jungclas, H; Pflüger, KH; Schmidt, L | 1 |
| de Ruiter, C; de Vries, J; Kootstra, PR; Lafleur, MV; Pinedo, HM; Retèl, J; van Maanen, JM | 1 |
| Anderson, PN; Baker, LH; Comis, RL; Daniels, JR; Einhorn, LH; Harvey, HA; Issell, BF; Lanzotti, VA; Lawson, RD; Wampler, GL | 1 |
| D'Incalci, M; Mangioni, C; Rossi, C; Roviaro, G; Sessa, C | 1 |
| Greco, FA; Grosh, WW; Hainsworth, JD; Hande, KR; Johnson, DH; Porter, LL; Wolff, SN | 1 |
| Klastersky, J; Sculier, JP; Stryckmans, P | 1 |
| Abratt, RP; Levin, W | 1 |
| Alonso, MT; Leyland-Jones, B; Marsoni, S; O'Dwyer, PJ; Wittes, RE | 1 |
| Ahmedzai, S; Banham, S; Burnett, A; Cunningham, D; Dorward, A; Hutcheon, A; Kaye, S; Lucie, N; Soukop, M | 1 |
| Greco, FA; Hainsworth, JD; Hande, KR; Johnson, DH; Porter, LL; Wolff, SN | 1 |
| Bateman, NT; Bellamy, D; Calman, FM; Costello, J; Farebrother, M; Rubens, RD; Slevin, ML; Timothy, AR | 1 |
| Bosl, GJ; Golbey, RB; Herr, H; MacDonald, G; Morse, M; Sogani, P; Vogelzang, N; Whitmore, W; Yagoda, A | 1 |
| Kimura, K; Niitani, H; Yamada, K | 1 |
| Chan, SY; Choo, YC; Ma, HK; Wong, LC | 1 |
| Finkel, H; Grapski, RT; Krikorian, JG; Lopez, JA; Mann, J; Nassif, E; Vannicola, P | 1 |
| Adelstein, DJ; Hines, JD | 1 |
| Kupfer, G; Ross, W; Rowe, T | 1 |
| Danigel, H; Dellbrügge, J; Jungclas, H; Pflüger, KH; Schmidt, L | 1 |
| Chikata, E; Hara, K; Ito, F; Kado, M; Kanda, T; Matsui, Y; Nakayama, M; Ohshima, S; Sakai, S; Shimokata, K | 1 |
| Harvey, VJ; Joel, SP; Johnston, A; Slevin, ML; Wrigley, PF | 2 |
| Kimura, K; Niitani, H | 1 |
| Liu, LF; Rowe, TC; Yang, L | 1 |
| Ahmedzai, S; Banham, SW; Cunningham, D; Dorward, A; Hutcheon, AH; Kaye, SB; Soukop, M; Stack, BR; Stevenson, RD; Tansey, P | 1 |
| Furuse, K | 1 |
| Harvey, VJ; Joel, SP; Johnston, A; Slevin, ML; Smythe, MM; Wrigley, PF | 1 |
| Hara, K; Kado, M; Kanda, T; Matsui, Y; Oshima, S; Shima, K; Shimokata, K; Takenaka, S | 1 |
| Glisson, B; Gupta, R; Ross, W; Smallwood-Kentro, S | 1 |
| Bakaert, AB; De Broe, ME; Holthuis, JJ; Van de Vyver, FL; van Oort, WJ; Verleun, H | 1 |
| Haim, N; Nemec, J; Roman, J; Sinha, BK | 1 |
| Livingston, RB | 1 |
| Hiraga, Y; Ito, T; Konno, K; Nagahama, F; Nakabayashi, T; Nakai, Y; Oizumi, K; Sato, M; Takebe, K; Tamura, M | 1 |
| Kinameri, K; Kurita, Y; Matsuura, N; Sano, K; Yokoyama, A | 1 |
| Hara, K; Ikebe, A; Ishizaki, T; Iwasaki, H; Kanda, T; Koteda, T; Nakano, M; Oka, M; Okuno, K; Tsutsumi, T | 1 |
| Glisson, BS; Hodges, PK; Ross, WE; Smallwood-Kentro, S; Sullivan, DM | 1 |
| Choo, YC; Ma, HK; Wong, LC | 3 |
| Birch, R; Greco, FA; Sarma, P; Wolff, SN | 1 |
| Brattain, MG; Long, BH; Musial, ST | 3 |
| Dorr, RT; Gerner, EW; Liddil, JD | 1 |
| Bentley, DP; Littlewood, TJ; Smith, AP | 1 |
| Cummings, J; Cunningham, D; Forrest, GJ; McTaggart, L; Soukop, M; Stuart, JF | 1 |
| White, JC; Wright, SE | 1 |
| Coles, DT; Creagan, ET; Eagan, RT; Frytak, S; Jett, JL; Lee, RE; Richardson, RL | 1 |
| Kerrigan, D; Kohn, KW; Pommier, Y | 1 |
| Holthuis, JJ | 1 |
| Dombernowsky, P; Hansen, HH | 1 |
| D'Incalci, M; Garattini, S | 2 |
| Nakajima, T; Ochi, H; Saijo, N; Shinkai, T; Suemasu, K; Tominaga, K | 1 |
| Bakkenist, TR; de Vries, J; Lankelma, J; Pinedo, HM; Retèl, J; van den Akker, E; Van Maanen, JM | 1 |
| Huijgens, PC; Ossenkoppele, GJ; Reijneke, RM; Thomas, LL; van der Lelie, J; Wijngaarden, MJ | 1 |
| Clark, PI; Slevin, ML | 1 |
| Bromke, A; Bryant, DW; Gupta, R; Gupta, RS; McCalla, DR; Singh, B | 1 |
| Chenchaiah, PC; Gupta, R; Gupta, RS | 1 |
| Chenchaiah, PC; Gupta, RS | 1 |
| Murray, SL; Slater, LM; Stupecky, M; Sweet, P; Wetzel, MW | 1 |
| Athanassiades, P; Bacoyiannes, H; Kontoyiannes, D | 1 |
| Birch, R; Einhorn, LH; Greco, FA; Troner, M; Walther, PJ; Williams, SD | 1 |
| Bartolucci, AA; Gockerman, JP; Nelson, MO; Silberman, H; Stein, R; Velez-Garcia, E | 1 |
| Creger, RJ; Diaz, D; Lazarus, HM | 1 |
| Andreeff, M; Ciobanu, N; Paietta, E; Papenhausen, P; Wiernik, PH | 1 |
| Canetta, R; Carbone, A; Tirelli, U; Veronesi, A; Zagonel, V | 1 |
| Cavalli, F; D'Incalci, M; Mangioni, C; Rossi, C; Sessa, C; Urso, R; Willems, Y; Zucchetti, M | 1 |
| Feun, LG; Fields, WS; Loo, TL; Lu, K; Savaraj, N; Wallace, S | 1 |
| Cummings, J; Cunningham, D; Forrest, GJ; Gilchrist, NL; Soukop, M | 1 |
| Amato, G; Broggini, M; Colombo, T; D'Incalci, M; Erba, E; Vaghi, M | 1 |
| Bugat, R; Canal, P; Carton, M; Michel, C; Soula, G | 1 |
| Feuer, EJ; Holland, JF; Hollis, PH; Johnson, J; Malis, LI; Spigelman, MK; Zappulla, RA | 1 |
| Hocking, WG; Swanson, M | 1 |
| Barlow, JJ; Lele, SB | 1 |
| Háber, J; Klener, P | 1 |
| Suzuki, K | 1 |
| Nishikawa, K; Okamoto, K; Takahashi, K; Uchida, T | 1 |
| Hiraoka, M; Nakanomyo, H; Shiraya, M | 1 |
| Kondo, S; Nishimura, Y; Saito, H; Takeuchi, T; Umezawa, H; Yoshikawa, H | 2 |
| Christensen, IJ; Hansen, HH; Roed, H; Spang-Thomsen, M; Vindelov, LL | 1 |
| Pirtoli, L; Tucci, E | 1 |
| Calabresi, F; Greco, C; Sacchi, A; Zupi, G | 1 |
| Abe, T; Kariyone, S; Maekawa, I; Maekawa, T; Miura, A; Miura, Y; Moriyama, Y; Shibata, A; Wakui, A; Yoshida, Y | 1 |
| Apostol, JV; Kucuk, O | 1 |
| Chang, TT; Chou, TC; Clarkson, BD; Colvin, M; Gandola, L; Gulati, SC; Ibrahim, SM; Vega, R; Yopp, J | 1 |
| Gross, M; Ross, WE; Yalowich, JC; Zucali, JR | 1 |
| Ogawa, M | 1 |
| Anderson, G; Payne, H | 1 |
| Maroun, JA; Nundy, D; Prior, J; Stewart, DJ; Tetreault, L | 1 |
| Dent, DM; Hayes, M; Jacobs, P; King, HS | 1 |
| Jacobs, P | 1 |
| Bentley, DP; Littlewood, TJ; Spragg, BP | 1 |
| Holden, SA; Rose, CM; Teicher, BA | 1 |
| Alvarado, CS; Buchanan, GR; Kim, TH; Ragab, AH; Sartain, P; Zaatari, G | 1 |
| Hashimoto, S; Kano, A; Kawamoto, K; Konno, K; Sakata, Y; Sato, S; Takahashi, H; Wakui, A; Yokoyama, M; Yoshida, Y | 1 |
| Cavallin-Ståhl, E; Hagberg, H; Lind, J | 1 |
| Kimura, K; Yamada, K; Yoshida, T | 1 |
| Buccheri, G; Curcio, A; Ferrigno, D; Mattalia, E; Vola, F | 1 |
| Goto, A; Haji, A; Hasegawa, Y; Hattori, N; Morita, M | 2 |
| Arakawa, S; Esumi, N; Imashuku, S; Todo, S | 1 |
| Estruch, R; Fernandez-Huerta, JM; Montserrat, E; Rozman, C; Urbano-Márquez, A | 1 |
| Aisner, J; Egorin, MJ; Jones, JM; Olman, EA | 1 |
| Cavalli, F | 2 |
| Comis, RL; Pfeffer, M; Scalzo, A; Smyth, RD | 1 |
| Ross, WE; Yalowich, JC | 2 |
| Floor, BJ; Klein, AE; Muhammad, N; Ross, D | 1 |
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| An, L; Han, Y; Miao, R; Wang, Q; Yang, J | 1 |
| Akhmedjanova, V; Balansard, G; Barthomeuf, C; Beliveau, R; Debiton, E; Grassi, J; Lim, S | 1 |
| Albo, C; Alonso, N; Arranz, R; Caballero, D; Conde, E; Fernández-Rañada, JM; Gandarillas, M; García Vela, JA; Garzón, S; Grande, C; Hernández, MT; Lahuerta, JJ; Mateos, MV; Rodríguez, J | 1 |
| Alegria, AE; Garcia, C; Gonzalez, FA; Gordaliza, M; Kumar, A; Orellano, A; Sanchez-Cruz, P; Zayas, B | 1 |
| Anklin, C; Bender, RP; Dunlap, N; Graves, DE; Jablonksy, MJ; Osheroff, N; Romaine, I; Shadid, M | 1 |
| Annereau, JP; Bailly, C; Barret, JM; Brel, V; Delcros, JG; Guilbaud, N; Guminski, Y; Imbert, T; Kruczynski, A; Lansiaux, A; Vispé, S | 1 |
| Lv, M; Tian, X; Xu, H | 1 |
| Du, W; He, Q; Hu, C; Hu, Y; Lou, J; Qian, S; Wang, L; Xu, D; Yang, B | 1 |
| Asmar, L; Beveridge, R; Boehm, KA; Mandanas, R; McGaughey, D; Orloff, G; Rifkin, R; Spitzer, G; Zhan, F | 1 |
| Bailly, C; Gentry, AC; Graves, DE; Jablonsky, MJ; Osheroff, N; Pitts, SL | 1 |
| Juvekar, A; Kamal, A; Kumar, BA; Suresh, P; Zingde, S | 1 |
| Lv, M; Xu, H | 1 |
| Chen, MC; Lee, KH; Li, TK; Pan, SL; Shi, Q; Teng, CM; Xiao, Z | 1 |
| Annereau, JP; Bailly, C; Brel, V; Guilbaud, N; Kruczynski, A; Vispé, S | 1 |
| Imthiajali, S; Kamal, A; Lavanya, A; Mallareddy, A; Pal-Bhadra, M; Pushpavalli, SN; Ramaiah, MJ; Suresh, P | 1 |
| Briere, J; Bron, D; Cogliatti, S; Cuccuini, W; Gaulard, P; Gisselbrecht, C; Hirchaud, E; Houlgatte, R; Mounier, N; Rosenwald, A; Soulier, J; Sundstrom, C; Thieblemont, C; Voelker, HU; Ysebaert, L | 1 |
| Andersen, NS; Bentzen, H; Brown, P; Delabie, J; Ehinger, M; Elonen, E; Eriksson, M; Geisler, CH; Jerkeman, M; Karjalainen-Lindsberg, ML; Kimby, E; Kolstad, A; Kuittinen, O; Laurell, A; Lauritzsen, GF; Nilsson-Ehle, H; Nordström, M; Pedersen, LB; Ralfkiaer, E; Räty, R; Sundström, C | 1 |
| Buschmann, MD; Gal, S; Jean, M; Li, Z; Liao, S; Merzouki, A; Slilaty, SN; Young, RS | 1 |
| Jin, S; Qi, SN; Yang, TM; Yang, YJ; Yuan, HQ; Zhang, B; Zhao, N | 1 |
| Kumar, D; Kumari, A; Yadav, R; Yadav, SK | 1 |
| Kou, L; Lee, KH; Liu, YQ; Morris-Natschke, SL; Nan, X; Wang, LT; Wang, MJ; Yang, L; Zhao, XB | 1 |
| Belada, D; Berková, A; Bolomská, I; Burešová, L; Campr, V; Klener, P; Kozák, T; Kubáčková, K; Matuška, M; Pirnos, J; Přibylová, J; Pytlík, R; Sýkorová, A; Trněný, M; Vášová, I | 1 |
| Chen, H; Luo, G; Zhang, LM; Zhang, S; Zhang, ZH; Zhou, J | 1 |
| Bailly, C; Bal-Mahieu, C; Boulet, E; Guilbaud, N; Kruczynski, A; Lansiaux, A; Lartigau, E; Leblond, P; Meignan, S; Pillon, A; Sarrazin, T | 1 |
| Hasinoff, BB; Patel, D; Wu, X; Yadav, AA; Yalowich, JC | 1 |
| Chee, GL; Hasinoff, BB; Patel, D; Wu, X; Yadav, AA; Yalowich, JC | 1 |
| O'Connor, SE | 1 |
| Lau, W; Sattely, ES | 1 |
| Basha, SA; Bhadra, MP; Bhadra, U; Kamal, A; Kavi Kishor, PB; Lavanya, A; Ramaiah, MJ; Srinivas, C; Yerramsetty, S | 1 |
| Hu, Y; Liao, JX; Liu, H; Sun, JS; Tu, YH | 1 |
| Chen, C; Geng, WY; Luo, DQ; Song, XM; Wang, CC; Wang, Z; Xu, H | 1 |
| Belaaloui, G; Jiang, ZZ; Khaled, M; Zhang, LY; Zhu, X | 1 |
| Baek, SW; Choi, YS; Jo, DY; Kim, S; Lee, HJ; Moon, JY; Ryu, H; Song, IC; Yun, HJ | 1 |
| Chen, SW; Guan, XW; Hui, L; Jin, YX; Xiang, R | 1 |
| Butcher, B; Chong, G; Cull, G; Fay, K; Filshie, R; Gandhi, MK; Gill, D; Grigg, A; Hahn, U; Hertzberg, M; Hicks, RJ; Ho, SJ; Hofman, MS; Johnston, A; Kannourakis, G; Lewis, ID; Milliken, S; Renwick, W; Seymour, JF; Taper, J; Trotman, J; Warburton, P; Watson, AM; Wirth, A | 1 |
| Jing, YX; Qi, SN; Shi, RY; Wang, LS; Yang, YJ; Yao, J; Yuan, HQ | 1 |
| Jakobs, A; Klempnauer, KH; Yusenko, M | 1 |
| Li, F; Li, R; Liao, X; Liu, D; Yang, B; Zhao, Y | 1 |
| Abounader, D; Andritsos, L; Benson, DM; Bolwell, B; Dean, R; Devine, SM; Efebera, YA; Elder, P; Hill, B; Hofmeister, CC; Jagadeesh, D; Jaglowski, S; Kalaycio, M; Majhail, NS; Penza, S; Pohlman, B; Rosko, A; Sharma, N; Singer, S; Sobecks, R; Vasu, S; William, BM; Zhao, Q | 1 |
| Jia, KZ; Li, S; Li, YZ; Qi, Q; Qu, X; Shen, Y; Tang, YJ; Zhang, Y; Zhu, LW | 1 |
| Boyé, P; Floch, F; Fournel-Fleury, C; Serres, F; Tierny, D | 1 |
| Castro, MÁ; Díez, D; Díez, P; Fuentes, M; García, PA; Hernández, ÁP; Jambrina, PG; Ortega, P; Pérez-Andrés, M | 1 |
| Duan, Y; Li, HM; Li, S; Li, YZ; Shen, Y; Tang, YJ; Zhang, Y; Zhao, W | 1 |
| Bosch, M; Danyluk, P; Dusyk, T; Elemary, M; Hahn, L; Lim, H; Sabry, W; Stakiw, J | 1 |
| Cao, X; Jiang, P; Li, L; Meng, J; Sun, F; Sun, W; Wang, C; Zhao, S | 1 |
43 review(s) available for podophyllotoxin and etoposide
| Article | Year |
|---|---|
Antiviral activity of lignans.
Topics: Animals; Antiviral Agents; Humans; Lignans; Plants, Medicinal; Viruses | 1998 |
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
Topics: Anti-HIV Agents; Biological Factors; Drug Design; Molecular Structure; Pharmaceutical Preparations; Plants, Medicinal | 2010 |
1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.
Topics: Antineoplastic Agents; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Triazoles | 2019 |
Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020).
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Molecular Structure; Podophyllotoxin; Stereoisomerism; Structure-Activity Relationship | 2020 |
VM 26 and VP 16-213: a comparative analysis.
Topics: Animals; Brain Neoplasms; Drug Evaluation; Etoposide; Humans; Kinetics; Leukemia; Lung Neoplasms; Lymphoma; Neoplasms, Experimental; Podophyllotoxin; Teniposide; Urinary Bladder Neoplasms | 1977 |
Etoposide (VP-16-213).
Topics: Adult; Animals; Bone Marrow; Cell Cycle; Child; Digestive System; Drug Therapy, Combination; Etoposide; Female; Humans; Leukemia; Lung Neoplasms; Lymphoma; Male; Mice; Neoplasms; Neoplasms, Experimental; Podophyllotoxin; Rats | 1979 |
Podophyllotoxin derivative VP 16-213.
Topics: Animals; Bronchial Neoplasms; Carcinoma; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Etoposide; Humans; In Vitro Techniques; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Lymphoma; Mice; Neoplasms; Podophyllotoxin; Rabbits; Rats; Sarcoma | 1979 |
Pediatric cancer chemotherapy: an updated review. I. Cis-Diammine--dichloroplatinum II (cisplatin), VM-26 (teniposide), VP-16 (etoposide), mitomycin C.
Topics: Child; Cisplatin; Clinical Trials as Topic; Drug Administration Schedule; Etoposide; Humans; Leukemia; Mitomycins; Neoplasms; Podophyllotoxin; Teniposide | 1979 |
Dose-intensity meta-analysis of chemotherapy regimens in small-cell carcinoma of the lung.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Drug Evaluation; Etoposide; Humans; Lung Neoplasms; Meta-Analysis as Topic; Podophyllotoxin; Vincristine | 1991 |
The chemical and biological route from podophyllotoxin glucoside to etoposide: ninth Cain memorial Award lecture.
Topics: Aldehydes; Antineoplastic Agents; Cell Division; Cyclosporins; Etoposide; Glucosides; Growth Inhibitors; History, 19th Century; History, 20th Century; Plants, Medicinal; Plants, Toxic; Podophyllotoxin; Podophyllum; Structure-Activity Relationship; Teniposide | 1991 |
Etoposide and teniposide in the treatment of acute leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Etoposide; Humans; Leukemia, Myeloid, Acute; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide | 1990 |
From podophyllotoxin glucoside to etoposide.
Topics: Animals; Chemistry; Etoposide; History, 20th Century; Humans; Podophyllotoxin | 1989 |
Etoposide (VP-16-213). Current status of an active anticancer drug.
Topics: Animals; Carcinoma, Small Cell; Clinical Trials as Topic; DNA; Drug Administration Schedule; Drug Evaluation; Drug Evaluation, Preclinical; Drug Resistance; Etoposide; Female; Hodgkin Disease; Humans; Leukemia; Lung Neoplasms; Lymphoma; Male; Mice; Podophyllotoxin; Testicular Neoplasms; Tissue Distribution | 1985 |
Current chemotherapy of small cell lung cancer.
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Combined Modality Therapy; Complement Membrane Attack Complex; Complement System Proteins; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Etoposide; Humans; Lomustine; Lung Neoplasms; Methotrexate; Mitomycin; Mitomycins; Podophyllotoxin; Procarbazine; Prognosis; Time Factors; Vincristine | 1986 |
Etoposide and teniposide. Bioanalysis, metabolism and clinical pharmacokinetics.
Topics: Etoposide; Humans; Podophyllotoxin; Teniposide | 1988 |
The epipodophyllotoxin derivatives VM26 and VP16: experimental and clinical aspects.
Topics: Animals; Antineoplastic Agents; Etoposide; Humans; Podophyllotoxin; Teniposide | 1988 |
Podophyllotoxin derivatives VP-16 and VM-26.
Topics: Animals; Drug Resistance; Etoposide; Humans; Molecular Structure; Podophyllotoxin; Teniposide | 1988 |
Podophyllotoxin derivatives VP-16 and VM-26.
Topics: Animals; Cell Survival; Drug Interactions; Drug Resistance; Etoposide; Humans; Podophyllotoxin; Teniposide | 1987 |
The clinical pharmacology of etoposide and teniposide.
Topics: Chemical Phenomena; Chemistry; Drug Stability; Etoposide; Humans; Kidney; Kinetics; Liver; Podophyllotoxin; Teniposide | 1987 |
Pharmacokinetics of anticancer drugs in children.
Topics: Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Child; Cyclophosphamide; Etoposide; Humans; Kinetics; Mercaptopurine; Methotrexate; Naphthacenes; Podophyllotoxin; Teniposide; Vinca Alkaloids | 1983 |
[Etoposide. A new highly effective cytostatic agent in anaplastic small-cell bronchial carcinoma, other solid tumors and hemoblastoses].
Topics: Bronchial Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Small Cell; Cell Division; Choriocarcinoma; Etoposide; Female; Humans; Leukemia; Liver Neoplasms; Lung Neoplasms; Male; Ovarian Neoplasms; Podophyllotoxin; Pregnancy; Testicular Neoplasms; Uterine Neoplasms | 1981 |
Etoposide (VP-16) in the treatment of lung cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Drug Evaluation; Etoposide; Humans; Lung Neoplasms; Podophyllotoxin; Time Factors | 1983 |
Review of etoposide single-agent activity.
Topics: Animals; Drug Administration Schedule; Etoposide; Female; Humans; Male; Neoplasms; Podophyllotoxin | 1982 |
The epipodophyllotoxin derivatives VM-26 and VP-16-213, 1976-1979, a review.
Topics: Animals; Antineoplastic Agents; Etoposide; Hodgkin Disease; Humans; Leukemia, Lymphoid; Lung Neoplasms; Podophyllotoxin; Teniposide | 1980 |
VP16-213 and podophyllotoxin. A study on the relationship between chemical structure and biological activity.
Topics: Animals; Chemical Phenomena; Chemistry; DNA; Etoposide; HeLa Cells; Humans; Microtubules; Molecular Conformation; Nucleosides; Podophyllotoxin; Structure-Activity Relationship; Teniposide | 1982 |
The clinical pharmacology of VM26 and VP16-213. A brief overview.
Topics: Biotransformation; Blood-Brain Barrier; Etoposide; Humans; Intestinal Absorption; Kinetics; Models, Biological; Podophyllotoxin; Teniposide; Tissue Distribution | 1982 |
The podophyllotoxin derivatives VP16-213 and VM26.
Topics: Animals; Chemical Phenomena; Chemistry; Drug Therapy, Combination; Etoposide; Humans; Neoplasms; Podophyllotoxin; Teniposide | 1982 |
VP16-213 (etoposide). A critical review of its activity.
Topics: Drug Evaluation; Etoposide; Humans; Neoplasms; Podophyllotoxin; Research Design | 1982 |
Current development of podophyllotoxins.
Topics: Chemistry, Pharmaceutical; Drug Compounding; Drug Stability; Drug Synergism; Drug Therapy, Combination; Etoposide; Humans; Kinetics; Podophyllotoxin; Teniposide | 1982 |
Intensive therapy and autotransplantation in Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Bone Marrow Transplantation; Carmustine; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Digestive System Diseases; Etoposide; Heart Diseases; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Lung Diseases; Melphalan; Multicenter Studies as Topic; Podophyllotoxin; Recurrence; Remission Induction; Salvage Therapy; Survival Rate; Treatment Outcome; Whole-Body Irradiation | 1994 |
Pharmacodynamics and long-term toxicity of etoposide.
Topics: Child; Etoposide; Humans; Leukemia; Leukemia, Myeloid, Acute; Male; Neoplasms; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Testicular Neoplasms | 1994 |
[A case of secondary leukemia in anaplastic seminoma patient treated with long-term chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Etoposide; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplasms, Second Primary; Podophyllotoxin; Seminoma; Testicular Neoplasms | 1996 |
Peripheral blood progenitor cell transplantation: a single centre experience comparing two mobilisation regimens in 67 patients.
Topics: Adolescent; Adult; Amyloidosis; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carmustine; Cell Movement; Colony-Forming Units Assay; Cyclophosphamide; Cytarabine; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Kidney Diseases; Leukapheresis; Leukocyte Count; Male; Melphalan; Middle Aged; Neoplasms; Podophyllotoxin; Retrospective Studies; Thiotepa; Transplantation Conditioning | 1996 |
Etoposide phosphate: what, why, where, and how?
Topics: Antineoplastic Agents; Carcinoma, Small Cell; Clinical Trials as Topic; Etoposide; Humans; Lung Neoplasms; Organophosphorus Compounds; Podophyllotoxin | 1996 |
Sarah Cannon Cancer Center Consensus Conference on Novel Developments with Podophyllotoxin Therapy.
Topics: Antineoplastic Agents, Phytogenic; Etoposide; Humans; Organophosphorus Compounds; Podophyllotoxin; Prodrugs | 1996 |
DNA topoisomerase II poisons and inhibitors.
Topics: Animals; Antineoplastic Agents; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Humans; Podophyllotoxin; Topoisomerase II Inhibitors | 1997 |
Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dexamethasone; Encephalitis; Etoposide; Female; Humans; Immunoglobulins, Intravenous; Immunosuppression Therapy; Injections, Spinal; Interferon-alpha; Interleukin-12; Leukoencephalopathy, Progressive Multifocal; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Melphalan; Memory Disorders; Middle Aged; Podophyllotoxin; Transplantation Conditioning; Transplantation, Autologous; Vincristine | 1999 |
Antitumor properties of podophyllotoxin and related compounds.
Topics: Antineoplastic Agents, Phytogenic; Antiviral Agents; Etoposide; Humans; Immunosuppressive Agents; Podophyllotoxin; Structure-Activity Relationship; Teniposide | 2000 |
Taxanes in the treatment of advanced (stage III and IV) non-small cell lung cancer (NSCLC): recent developments.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Docetaxel; Etoposide; Female; Gemcitabine; Humans; Lung Neoplasms; Male; Microtubules; Multicenter Studies as Topic; Neoadjuvant Therapy; Organoplatinum Compounds; Paclitaxel; Palliative Care; Podophyllotoxin; Randomized Controlled Trials as Topic; Salvage Therapy; Survival Analysis; Taxoids; Teniposide; Treatment Outcome; Vinblastine; Vinorelbine | 2003 |
Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives.
Topics: Cytotoxins; Etoposide; Lignans; Organophosphorus Compounds; Plants, Toxic; Podophyllotoxin; Teniposide; Tumor Cells, Cultured | 2004 |
Toxicity of the topoisomerase II inhibitors.
Topics: Antineoplastic Agents; Cardiovascular Diseases; Daunorubicin; Doxorubicin; Enzyme Inhibitors; Epirubicin; Etoposide; Humans; Idarubicin; Leukemia; Middle Aged; Mitoxantrone; Mucositis; Podophyllotoxin; Teniposide; Topoisomerase II Inhibitors; Vascular Diseases | 2005 |
A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Etoposide; Humans; Inhibitory Concentration 50; Organophosphorus Compounds; Podophyllotoxin; Structure-Activity Relationship; Teniposide | 2009 |
Recent advances in semisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: an update (2008-2010).
Topics: Antineoplastic Agents, Phytogenic; Cell Survival; Drug Screening Assays, Antitumor; Etoposide; Humans; Organophosphorus Compounds; Podophyllotoxin; Structure-Activity Relationship; Teniposide | 2011 |
57 trial(s) available for podophyllotoxin and etoposide
| Article | Year |
|---|---|
VP-16-213 versus polychemotherapy in patients with advanced small cell lung cancer.
Topics: Adult; Aged; Bleomycin; Cyclophosphamide; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Podophyllotoxin; Prognosis; Vincristine | 1976 |
Therapeutic trials with VP-16-213 and VM-26: active agents in small cell lung cancer, non-Hodgkin's lymphomas, and other malignancies.
Topics: Alopecia; Carcinoma, Small Cell; Clinical Trials as Topic; Drug Evaluation; Etoposide; Humans; Leukemia; Leukopenia; Lung Neoplasms; Lymphoma; Podophyllotoxin; Teniposide | 1979 |
VP-16-213 monotherapy for remission induction of small cell lung cancer: a randomized trial using three dosage schedules.
Topics: Carcinoma; Clinical Trials as Topic; Drug Administration Schedule; Etoposide; Humans; Lung Neoplasms; Middle Aged; Podophyllotoxin | 1978 |
Phase I trial of a new form of an oral administration of VP-16-213.
Topics: Administration, Oral; Adult; Aged; Capsules; Clinical Trials as Topic; Drug Evaluation; Etoposide; Female; Hematologic Diseases; Humans; Male; Middle Aged; Neoplasms; Podophyllotoxin | 1979 |
Phase II study of single-agent therapy with megestrol acetate, VP-16-213, cyclophosphamide, and dianhydrogalactitol in advanced renal cell cancer.
Topics: Adenocarcinoma; Adult; Aged; Clinical Trials as Topic; Cyclophosphamide; Dianhydrogalactitol; Drug Evaluation; Etoposide; Humans; Kidney Neoplasms; Megestrol; Middle Aged; Neoplasm Metastasis; Podophyllotoxin; Sugar Alcohols | 1979 |
Podophyllotoxin derivative VP 16-213.
Topics: Animals; Bronchial Neoplasms; Carcinoma; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Etoposide; Humans; In Vitro Techniques; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Lymphoma; Mice; Neoplasms; Podophyllotoxin; Rabbits; Rats; Sarcoma | 1979 |
Pediatric cancer chemotherapy: an updated review. I. Cis-Diammine--dichloroplatinum II (cisplatin), VM-26 (teniposide), VP-16 (etoposide), mitomycin C.
Topics: Child; Cisplatin; Clinical Trials as Topic; Drug Administration Schedule; Etoposide; Humans; Leukemia; Mitomycins; Neoplasms; Podophyllotoxin; Teniposide | 1979 |
Phase II evaluation of diglycoaldehyde, VP-16-213, and the combination of methyl-CCNU and beta-2'-deoxythioguanosine in previously treated patients with colorectal cancer: an Eastern Cooperative Oncology Group study (EST-1275).
Topics: Aldehydes; Colonic Neoplasms; Deoxyguanosine; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Humans; Inosine; Male; Nitrosourea Compounds; Podophyllotoxin; Rectal Neoplasms; Semustine; Thionucleosides | 1979 |
VP 16-213 in acute myelogenous leukaemia.
Topics: Adult; Aged; Clinical Trials as Topic; Drug Evaluation; Etoposide; Female; Humans; Leukemia, Myeloid; Male; Middle Aged; Podophyllotoxin; Remission, Spontaneous | 1976 |
Phase II studies of dianhydrogalactitol and VP-16-213 in colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Drug Evaluation; Ethers, Cyclic; Etoposide; Female; Galactitol; Humans; Male; Middle Aged; Podophyllotoxin; Rectal Neoplasms; Sugar Alcohols | 1976 |
Evaluation of VP-16 and the combination of adriamycin and vincristine in advanced breast cancer.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Humans; Neoplasm Metastasis; Podophyllotoxin; Remission, Spontaneous; Vincristine | 1976 |
Comparison of the biologic activity of VP-16-213 given iv and orally in capsules or drink ampules.
Topics: Administration, Oral; Blood Cell Count; Blood Platelets; Etoposide; Humans; Infusions, Parenteral; Leukocytes; Podophyllotoxin | 1976 |
Phase II study of VP-16-213 versus dianhydrogalactitol in patients with metastatic malignant melanoma.
Topics: Drug Evaluation; Drug Therapy, Combination; Ethers, Cyclic; Etoposide; Female; Galactitol; Humans; Male; Melanoma; Podophyllotoxin; Sugar Alcohols | 1976 |
Phase II evaluation of VP-16-213 (NSC-141540) and cytembena (NSC-104801) in patients with advanced breast cancer.
Topics: Acrylates; Breast Neoplasms; Drug Therapy, Combination; Etoposide; Female; Humans; Podophyllotoxin | 1976 |
Dose-intensity meta-analysis of chemotherapy regimens in small-cell carcinoma of the lung.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Drug Evaluation; Etoposide; Humans; Lung Neoplasms; Meta-Analysis as Topic; Podophyllotoxin; Vincristine | 1991 |
Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Humans; Leukemia, Myeloid; Neoplasms, Second Primary; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Teniposide | 1991 |
Teniposide and cisplatin given by intraperitoneal administration: preclinical and phase I/pharmacokinetic studies.
Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Evaluation; Drug Synergism; Etoposide; Female; Humans; Injections, Intraperitoneal; Leukemia P388; Leukopenia; Male; Mice; Middle Aged; Peritoneal Neoplasms; Podophyllotoxin; Remission Induction; Teniposide | 1991 |
Potential advances in combination chemotherapy for advanced testicular cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Clinical Trials as Topic; Etoposide; Humans; Ifosfamide; Male; Neoplasm Metastasis; Podophyllotoxin; Testicular Neoplasms; Vinblastine; Vincristine | 1988 |
Etoposide (VP-16-213). Current status of an active anticancer drug.
Topics: Animals; Carcinoma, Small Cell; Clinical Trials as Topic; DNA; Drug Administration Schedule; Drug Evaluation; Drug Evaluation, Preclinical; Drug Resistance; Etoposide; Female; Hodgkin Disease; Humans; Leukemia; Lung Neoplasms; Lymphoma; Male; Mice; Podophyllotoxin; Testicular Neoplasms; Tissue Distribution | 1985 |
[Phase I clinical study of NK 171 (etoposide)].
Topics: Administration, Oral; Adult; Aged; Carcinoma, Hepatocellular; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Infusions, Parenteral; Liver Neoplasms; Lung Neoplasms; Lymphoma; Male; Middle Aged; Neoplasms; Podophyllotoxin | 1985 |
Randomized dose-response evaluation of etoposide in small cell carcinoma of the lung: a Southeastern Cancer Study Group Trial.
Topics: Carcinoma, Small Cell; Clinical Trials as Topic; Dose-Response Relationship, Drug; Etoposide; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Podophyllotoxin; Random Allocation | 1986 |
Etoposide (VP-16-213) and cis-dichlorodiammineplatinum (DDP) in advanced breast carcinoma resistant to previous chemotherapy.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Etoposide; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Neoplasm Metastasis; Podophyllotoxin; Vincristine | 1986 |
Phase II study of etoposide for carcinoma of the prostate.
Topics: Blood Cell Count; Clinical Trials as Topic; Drug Evaluation; Etoposide; Hematologic Diseases; Humans; Male; Podophyllotoxin; Prostatic Neoplasms | 1986 |
Phase II evaluation of etoposide in refractory multiple myeloma: a Southeastern Cancer Study Group Trial.
Topics: Clinical Trials as Topic; Drug Evaluation; Etoposide; Female; Hematologic Diseases; Humans; Male; Middle Aged; Multiple Myeloma; Podophyllotoxin | 1986 |
Response rate and toxicity of etoposide (VP-16) in squamous carcinoma of the lung: report from the Lung Cancer Treatment Study Group.
Topics: Carcinoma, Squamous Cell; Clinical Trials as Topic; Etoposide; Humans; Lung Neoplasms; Podophyllotoxin | 1985 |
Bioavailability, pharmacokinetics, and clinical effects of an oral preparation of etoposide.
Topics: Administration, Oral; Biological Availability; Capsules; Clinical Trials as Topic; Drug Administration Schedule; Etoposide; Granulocytes; Half-Life; Humans; Infusions, Parenteral; Kinetics; Leukocyte Count; Nausea; Neoplasms; Platelet Count; Podophyllotoxin; Random Allocation | 1985 |
VP-16-213 in the treatment of stage III and IV diffuse large cell lymphoma.
Topics: Alopecia; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Leukopenia; Lymphoma; Male; Middle Aged; Podophyllotoxin; Prognosis; Prospective Studies; Random Allocation | 1985 |
The epipodophyllotoxin VP16-213 in combination chemotherapy for adults with acute nonlymphoblastic leukaemia.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cytarabine; Doxorubicin; Etoposide; Humans; Leukemia; Podophyllotoxin; Thioguanine | 1985 |
VP-16-213 in combination chemotherapy with chest irradiation for small-cell lung cancer: a randomized trial of the Piedmont Oncology Association.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Podophyllotoxin; Vincristine | 1984 |
VP-16-213 (etoposide): the mandrake root from Issyk-Kul.
Topics: Animals; Breast Neoplasms; Carcinoma, Small Cell; Cell Cycle; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Dysgerminoma; Etoposide; Female; Humans; Leukemia; Lung Neoplasms; Lymphoma; Mice; Podophyllotoxin | 1982 |
Doxorubicin, Cyclophosphamide and VP16-213 (ACE) in the treatment of small cell lung cancer.
Topics: Adult; Aged; Brain Neoplasms; Carcinoma, Small Cell; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1982 |
Induction of remission in hepatocellular carcinoma. A comparison of VP 16 with adriamycin.
Topics: Adolescent; Adult; Aged; Carcinoma, Hepatocellular; Doxorubicin; Etoposide; Female; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Pilot Projects; Podophyllotoxin; Prognosis; Random Allocation | 1983 |
Lack of potentiation of vincristine-induced neurotoxicity by VP-16-213.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nervous System Diseases; Podophyllotoxin; Random Allocation; Vincristine | 1983 |
[New antineoplastic drugs of the podophyllotoxin derivative group].
Topics: Adult; Child; Clinical Trials as Topic; Etoposide; Female; Humans; Leukemia; Lung Neoplasms; Lymphoma; Neoplasms; Ovarian Neoplasms; Podophyllotoxin; Teniposide; Urinary Bladder Neoplasms | 1983 |
[Phase II study of etoposide (NK 171) in advanced hematological malignancies].
Topics: Administration, Oral; Adolescent; Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Infusions, Parenteral; Leukemia; Leukopenia; Lymphoma; Male; Middle Aged; Nausea; Podophyllotoxin; Prednisolone; Thrombocytosis; Vincristine | 1984 |
A phase II trial of VP 16-213 in adults with refractory acute myeloid leukemia. An Eastern Cooperative Oncology Group study.
Topics: Adult; Bone Marrow; Drug Evaluation; Etoposide; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Podophyllotoxin | 1984 |
Doxorubicin plus VP-16-213 for the treatment of refractory breast carcinoma.
Topics: Adult; Aged; Breast Neoplasms; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Humans; Infusions, Parenteral; Leukopenia; Middle Aged; Podophyllotoxin; Thrombocytopenia | 1982 |
Cis-dichlorodiammineplatinum (II), VP 16-213, and prednisone (DVP regimen) in the treatment of pretreated advanced malignant lymphomas.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Drug Therapy, Combination; Etoposide; Female; Humans; Lymphoma; Male; Middle Aged; Neoplasm Staging; Podophyllotoxin; Prednisone | 1982 |
Clinical trial of VP 16--213 (NSC 141540) I.V. twice weekly in advanced neoplastic disease: a study by the Cancer and Leukemia Group B.
Topics: Adult; Bone Marrow; Child; Clinical Trials as Topic; Drug Administration Schedule; Etoposide; Female; Humans; Injections, Intravenous; Male; Neoplasms; Podophyllotoxin; Remission, Spontaneous | 1980 |
VP 16-213 and cyclophosphamide in the treatment of refractory acute nonlymphocytic leukemia with monocytic features.
Topics: Adult; Aged; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; Etoposide; Female; Humans; Leukemia, Monocytic, Acute; Male; Middle Aged; Podophyllotoxin | 1981 |
[Randomized phase II study with VP-16-213 (etoposide) in the treatment of advanced breast cancer].
Topics: Administration, Oral; Breast Neoplasms; Drug Evaluation; Etoposide; Female; Humans; Injections, Intravenous; Middle Aged; Podophyllotoxin; Prognosis; Random Allocation | 1981 |
[Etoposide VP 16--213)--a podophyllotoxinderivative with high antitumor activity (author's transl)].
Topics: Animals; Chemical Phenomena; Chemistry; Clinical Trials as Topic; DNA, Neoplasm; Drug Therapy, Combination; Etoposide; Humans; Neoplasms; Neoplasms, Experimental; Podophyllotoxin; RNA, Neoplasm | 1981 |
An evaluation of two schedules of VP-16 and adriamycin in patients with advanced breast cancer.
Topics: Bone Marrow; Breast Neoplasms; Cardiomyopathies; Doxorubicin; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Humans; Male; Podophyllotoxin; Remission, Spontaneous; Time Factors | 1980 |
Peripheral blood progenitor cell transplantation: a single centre experience comparing two mobilisation regimens in 67 patients.
Topics: Adolescent; Adult; Amyloidosis; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carmustine; Cell Movement; Colony-Forming Units Assay; Cyclophosphamide; Cytarabine; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Kidney Diseases; Leukapheresis; Leukocyte Count; Male; Melphalan; Middle Aged; Neoplasms; Podophyllotoxin; Retrospective Studies; Thiotepa; Transplantation Conditioning | 1996 |
BEAC or BEAM for high-dose therapy in patients with non-Hodgkin's lymphoma? A single centre analysis on toxicity and efficacy.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Non-Hodgkin; Male; Melphalan; Middle Aged; Podophyllotoxin; Prognosis; Survival Rate; Transplantation, Autologous | 2003 |
Low-dose oral etoposide-based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Child, Preschool; Dexamethasone; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Infant; Male; Neoplasm Recurrence, Local; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Treatment Outcome; Vincristine | 2004 |
Upfront double high-dose chemotherapy with DICEP followed by BEAM and autologous stem cell transplantation for poor-prognosis aggressive non-Hodgkin lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cisplatin; Cyclophosphamide; Cytarabine; Disease-Free Survival; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; L-Lactate Dehydrogenase; Lymphoma, Non-Hodgkin; Male; Melphalan; Middle Aged; Podophyllotoxin; Prednisone; Prognosis; Prospective Studies; Recurrence; Remission Induction; Risk Factors; Stem Cell Transplantation; Survival Rate; Transplantation, Autologous; Vincristine | 2006 |
Randomised phase III study of R-ICE versus R-DHAP in relapsed patients with CD20 diffuse large B-cell lymphoma (DLBCL) followed by high-dose therapy and a second randomisation to maintenance treatment with rituximab or not: an update of the CORAL study.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carmustine; Cisplatin; Combined Modality Therapy; Cytarabine; Dexamethasone; Disease-Free Survival; Dose-Response Relationship, Drug; Etoposide; Hodgkin Disease; Humans; Ifosfamide; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Podophyllotoxin; Remission Induction; Rituximab; Salvage Therapy; Stem Cell Transplantation; Survival Rate; Transplantation, Autologous; Treatment Outcome | 2006 |
Outpatient autologous hematopoietic stem cell transplantation for patients with relapsed follicular lymphoma.
Topics: Adult; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Cytarabine; Disease-Free Survival; Etoposide; Female; Follow-Up Studies; Gastrointestinal Diseases; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Follicular; Male; Melphalan; Middle Aged; Neutropenia; Podophyllotoxin; Retrospective Studies; Transplantation Conditioning; Transplantation, Autologous | 2006 |
Morbidity and transplant-related mortality of CBV and BEAM preparative regimens for patients with lymphoid malignancies undergoing autologous stem-cell transplantation.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hepatic Veno-Occlusive Disease; Humans; Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Male; Melphalan; Middle Aged; Morbidity; Mortality; Podophyllotoxin; Transplantation Conditioning; Transplantation, Autologous | 2006 |
Combination chemotherapy followed by autologous stem cell transplant for enteropathy-associated T cell lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Celiac Disease; Combined Modality Therapy; Cytarabine; Enteral Nutrition; Epirubicin; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Humans; Ifosfamide; Immunosuppressive Agents; Lymphoma, T-Cell, Peripheral; Male; Melphalan; Methotrexate; Middle Aged; Peripheral Blood Stem Cell Transplantation; Podophyllotoxin; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome | 2007 |
Dose-escalated CHOP and tailored intensification with IFE according to early response and followed by BEAM/autologous stem-cell transplantation in poor-risk aggressive B-cell lymphoma: a prospective study from the GEL-TAMO Study Group.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Administration Schedule; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Lymphoma, Large B-Cell, Diffuse; Male; Melphalan; Middle Aged; Podophyllotoxin; Prednisone; Prognosis; Prospective Studies; Risk Assessment; Stem Cell Transplantation; Survival Analysis; Transplantation, Autologous; Vincristine | 2008 |
Pegfilgrastim appears equivalent to daily dosing of filgrastim to treat neutropenia after autologous peripheral blood stem cell transplantation in patients with non-Hodgkin lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Cytarabine; Etoposide; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Non-Hodgkin; Male; Melphalan; Middle Aged; Neoplasm Staging; Neutropenia; Podophyllotoxin; Polyethylene Glycols; Recombinant Proteins; Transplantation, Autologous; Young Adult | 2010 |
MYC+ diffuse large B-cell lymphoma is not salvaged by classical R-ICE or R-DHAP followed by BEAM plus autologous stem cell transplantation.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Cytarabine; Dexamethasone; Etoposide; Female; Genes, myc; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Immunotherapy; Lymphoma, Large B-Cell, Diffuse; Male; Melphalan; Middle Aged; Podophyllotoxin; Rituximab; Salvage Therapy; Transplantation, Autologous; Treatment Failure; Young Adult | 2012 |
Nordic MCL2 trial update: six-year follow-up after intensive immunochemotherapy for untreated mantle cell lymphoma followed by BEAM or BEAC + autologous stem-cell support: still very long survival but late relapses do occur.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Cytarabine; Disease-Free Survival; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunotherapy; Lymphoma, Mantle-Cell; Male; Melphalan; Middle Aged; Podophyllotoxin; Prognosis; Recurrence; Rituximab; Survival Rate; Transplantation, Autologous | 2012 |
Early treatment intensification with R-ICE and 90Y-ibritumomab tiuxetan (Zevalin)-BEAM stem cell transplantation in patients with high-risk diffuse large B-cell lymphoma patients and positive interim PET after 4 cycles of R-CHOP-14.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carmustine; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Fluorodeoxyglucose F18; Humans; Ifosfamide; Lymphoma, Large B-Cell, Diffuse; Male; Melphalan; Middle Aged; Podophyllotoxin; Positron-Emission Tomography; Prednisone; Retreatment; Rituximab; Treatment Outcome; Vincristine; Young Adult | 2017 |
Prognostic value of pretreatment plasma D-dimer level in dogs with intermediate to high-grade non-Hodgkin lymphoma.
Topics: Animals; Antineoplastic Agents; Dog Diseases; Dogs; Double-Blind Method; Etoposide; Female; Fibrin Fibrinogen Degradation Products; Lymphoma, Non-Hodgkin; Male; Organophosphorus Compounds; Podophyllotoxin; Prognosis; Thymidine Kinase | 2021 |
472 other study(ies) available for podophyllotoxin and etoposide
| Article | Year |
|---|---|
Isolation, purification, and cytotoxicity of 5-methoxypodophyllotoxin, a lignan from a root culture of Linum flavum.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Ehrlich Tumor; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Mice; Molecular Structure; Plants; Podophyllotoxin; Tumor Cells, Cultured | 1992 |
Synthesis and antitumor activity of structural analogues of the epipodophyllotoxins.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma; Chemical Phenomena; Chemistry; Colonic Neoplasms; Etoposide; Humans; Indans; Leukemia P388; Lung Neoplasms; Mice; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Tumor Cells, Cultured | 1991 |
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models.
Topics: Animals; Antineoplastic Agents; Astrocytoma; Bucladesine; Cell Differentiation; Dioxoles; DNA Topoisomerases, Type I; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Tubulin | 1987 |
Antitumor agents. 78. Inhibition of human DNA topoisomerase II by podophyllotoxin and alpha-peltatin analogues.
Topics: Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Humans; Leukemia, Lymphoid; Molecular Weight; Plants; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1986 |
Synthesis and cytotoxicity of novel lignans.
Topics: Antineoplastic Agents; Carcinoma, Small Cell; Humans; Lignans; Lung Neoplasms; Tumor Cells, Cultured | 1995 |
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
Topics: Antineoplastic Agents; Cell Division; Colchicine; DNA; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; KB Cells; Topoisomerase II Inhibitors; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 1998 |
Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611.
Topics: Animals; Antineoplastic Agents; Biopolymers; Drug Screening Assays, Antitumor; Female; Glycosides; Glycosylation; Humans; Inhibitory Concentration 50; Leukemia L1210; Leukemia P388; Mice; Mice, Inbred DBA; Podophyllotoxin; Stereoisomerism; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transplantation, Heterologous; Tubulin; Tumor Cells, Cultured | 1998 |
Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Podophyllotoxin; Tumor Cells, Cultured | 1998 |
9-Deoxopodophyllotoxin derivatives as anti-cancer agents.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Podophyllotoxin; Tumor Cells, Cultured | 1999 |
Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Chlorocebus aethiops; DNA; Drug Design; Drug Screening Assays, Antitumor; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Microbial Sensitivity Tests; Nucleic Acid Hybridization; Podophyllotoxin; Structure-Activity Relationship; Tumor Cells, Cultured; Vero Cells | 2001 |
Synthesis and cytotoxicity of hydrophobic esters of podophyllotoxins.
Topics: Animals; Cell Line, Tumor; Esters; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Mice, Inbred DBA; Podophyllotoxin | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Structural simplification of bioactive natural products with multicomponent synthesis: dihydropyridopyrazole analogues of podophyllotoxin.
Topics: Antineoplastic Agents; Apoptosis; Biological Products; Humans; Jurkat Cells; Methods; Podophyllotoxin; Pyrazoles; Structure-Activity Relationship | 2007 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 3-Ring; Humans; Lymphocytes; Podophyllotoxin; Pyrazoles; Stereoisomerism; Structure-Activity Relationship | 2007 |
Studies on novel 4beta-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxins as potential anticancer agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Design; Humans; Inhibitory Concentration 50; Podophyllotoxin; Stereoisomerism; Substrate Specificity; Triazoles | 2008 |
Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
Topics: Animals; Binding Sites; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Mice; Molecular Conformation; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Peptide Library; Podophyllotoxin; Protein Binding; Protein Structure, Tertiary; Stereoisomerism; Structure-Activity Relationship; Time Factors | 2008 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents.
Topics: Antimitotic Agents; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Activation; Flow Cytometry; Humans; Podophyllotoxin; Structure-Activity Relationship; Tubulin | 2011 |
Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi.
Topics: Antineoplastic Agents, Phytogenic; Berberidaceae; Cell Line, Tumor; Cell Survival; Glucosides; HeLa Cells; Humans; Inhibitory Concentration 50; Lignans; Magnetic Resonance Spectroscopy; Plant Roots; Podophyllotoxin | 2011 |
Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Comet Assay; DNA; DNA Damage; Drug Screening Assays, Antitumor; Etoposide; Humans; Neoplasms; Podophyllotoxin | 2011 |
Synthesis of 4β-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents.
Topics: Antineoplastic Agents; Azides; Cell Line, Tumor; Cyclization; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Podophyllotoxin; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Triazoles | 2011 |
Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays.
Topics: Animals; Antimitotic Agents; Apoptosis; Aza Compounds; Caspase 2; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Embryo, Nonmammalian; Humans; Microtubules; Petroselinum; Plant Extracts; Plant Oils; Podophyllotoxin; Sea Urchins; Seeds; Stereoisomerism; Structure-Activity Relationship; Tubulin Modulators | 2011 |
Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Chalcone; Cinnamates; DNA Fragmentation; Enzyme Activation; Humans; Podophyllotoxin | 2012 |
Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; Drugs, Chinese Herbal; Enzyme Activation; Fluorouracil; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; Neoplasms; Podophyllotoxin | 2012 |
Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)-podophyllotoxin derivatives.
Topics: Animals; Cell Line; Cell Survival; Gene Expression Regulation, Enzymologic; Humans; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2012 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; DNA; DNA Fragmentation; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; HeLa Cells; Heterocyclic Compounds; HT29 Cells; Humans; M Phase Cell Cycle Checkpoints; Mice; Podophyllotoxin | 2013 |
Synthesis and cytotoxic activity on human cancer cells of carbamate derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin.
Topics: Antineoplastic Agents; Apoptosis; Carbamates; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; HL-60 Cells; Humans; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship | 2013 |
Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; DNA Fragmentation; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Humans; Podophyllotoxin; Polymerization; Tubulin; Tubulin Modulators | 2014 |
Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Heterocyclic Compounds, 4 or More Rings; Humans; MCF-7 Cells; Molecular Structure; Phenanthrolines; Polymerization; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2014 |
Synthesis and evaluation of novel podophyllotoxin derivatives as potential antitumor agents.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Resistance, Multiple; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; K562 Cells; Podophyllotoxin; RNA, Messenger | 2014 |
Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2014 |
Investigation of podophyllotoxin esters as potential anticancer agents: synthesis, biological studies and tubulin inhibition properties.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Esters; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2015 |
One-pot synthesis of podophyllotoxin-thiourea congeners by employing NH₂SO₃H/NaI: Anticancer activity, DNA topoisomerase-II inhibition, and apoptosis inducing agents.
Topics: Amides; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Podophyllotoxin; Sodium Iodide; Structure-Activity Relationship; Sulfur Oxides; Thiourea; Topoisomerase II Inhibitors | 2015 |
Synthesis and biological evaluation of a novel artesunate-podophyllotoxin conjugate as anticancer agent.
Topics: Antineoplastic Agents; Artemisinins; Artesunate; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; K562 Cells; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship | 2016 |
Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Humans; MCF-7 Cells; Microtubules; Molecular Docking Simulation; Neoplasms; Podophyllotoxin; Stereoisomerism; Tubulin; Tubulin Modulators | 2016 |
Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Humans; Lignans; Models, Molecular; Neoplasms; Piper; Seeds | 2016 |
Design, synthesis and anti-cancer activity evaluation of podophyllotoxin-norcantharidin hybrid drugs.
Topics: Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; MCF-7 Cells; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship | 2016 |
Design, synthesis and evaluation of the multidrug resistance-reversing activity of pyridine acid esters of podophyllotoxin in human leukemia cells.
Topics: Cell Line, Tumor; Drug Design; Drug Resistance, Multiple; Esters; Humans; Inhibitory Concentration 50; Leukemia; MAP Kinase Signaling System; Podophyllotoxin; Pyridines | 2016 |
Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents.
Topics: Acetates; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Esters; Humans; MCF-7 Cells; Molecular Structure; Piperazine; Piperazines; Podophyllotoxin; Polymerization; Structure-Activity Relationship; Tubulin | 2017 |
Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors.
Topics: Antineoplastic Agents; Carbolines; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2018 |
4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Humans; Male; Membrane Potential, Mitochondrial; Molecular Docking Simulation; Molecular Structure; Podophyllotoxin; Prostatic Neoplasms; Reactive Oxygen Species; Structure-Activity Relationship; Topoisomerase II Inhibitors; Triazoles; Tumor Cells, Cultured | 2018 |
Design, synthesis and antineoplastic activity of novel hybrids of podophyllotoxin and indirubin against human leukaemia cancer cells as multifunctional anti-MDR agents.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Down-Regulation; Drug Design; Drug Resistance, Neoplasm; G2 Phase Cell Cycle Checkpoints; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Dynamics Simulation; Multidrug Resistance-Associated Proteins; Podophyllotoxin; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Signal Transduction; Tubulin | 2018 |
Design, synthesis and screening of 1, 2, 4-triazinone derivatives as potential antitumor agents with apoptosis inducing activity on MCF-7 breast cancer cell line.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Drug Design; Female; Humans; MCF-7 Cells; Topoisomerase II Inhibitors; Triazines; Tubulin; Tubulin Modulators | 2018 |
Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain.
Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Cycle Checkpoints; Colchicine; Drug Design; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; Podophyllotoxin; Tubulin; Tubulin Modulators | 2019 |
Antiproliferative activity of diarylnaphthylpyrrolidine derivative via dual target inhibition.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; G2 Phase Cell Cycle Checkpoints; Humans; Male; Mice; Molecular Docking Simulation; Naphthalenes; Pyrrolidines; Topoisomerase II Inhibitors; Tubulin Modulators | 2020 |
Synthesis and evaluation of etoposide and podophyllotoxin analogs against topoisomerase IIα and HCT-116 cells.
Topics: A549 Cells; Antineoplastic Agents; Cell Proliferation; Cell Survival; DNA Cleavage; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Etoposide; HCT116 Cells; Humans; Molecular Docking Simulation; Molecular Structure; Plasmids; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2020 |
Epipodophylin derivative (VP 16-23) in malignant teratomas and choriocarcinomas.
Topics: Choriocarcinoma; Etoposide; Female; Humans; Podophyllotoxin; Pregnancy; Teratoma; Uterine Neoplasms | 1977 |
Comparative study of early effects of epipodophyllotoxin derivatives and other cytostatic agents on mastocytoma cultures.
Topics: Antineoplastic Agents; Bleomycin; Cell Division; Cell Line; Colchicine; Cytarabine; DNA, Neoplasm; Etoposide; Mast-Cell Sarcoma; Mechlorethamine; Mercaptopurine; Methotrexate; Mitosis; Neoplasm Proteins; Neoplasms, Experimental; Podophyllotoxin; Razoxane; RNA, Neoplasm; Teniposide; Vincristine; X-Rays | 1977 |
Epipodophyllin derivative (VP 16-213) in treatment of solid tumours.
Topics: Carcinoma, Hepatocellular; Etoposide; Humans; Liver Neoplasms; Podophyllotoxin; Teratoma | 1977 |
[Therapeutic experiences using the new podophyllotoxin derivative VP 16-213 in malignant human tumors].
Topics: Adenocarcinoma; Bronchial Neoplasms; Carcinoma; Carcinoma, Small Cell; Etoposide; Female; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Male; Middle Aged; Neoplasms; Ovarian Neoplasms; Podophyllotoxin; Prostatic Neoplasms; Remission, Spontaneous | 1975 |
Treatment of small cell anaplastic carcinoma of the lung with the oral solution of VP-16-213 (NSC 141540, 4'-demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside).
Topics: Administration, Oral; Aged; Carcinoma, Small Cell; Etoposide; Female; Humans; Leukopenia; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Remission, Spontaneous; Solutions | 1977 |
[Therapeutic results using VP 16-213 alone or in combination with 5-fluorouracil in liver cancer (hepatoma)].
Topics: Adult; Aged; Carcinoma, Hepatocellular; Drug Therapy, Combination; Etoposide; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Podophyllotoxin | 1977 |
Chemotherapy of small cell carcinoma of the lung with V.P. 16-213.
Topics: Bone Marrow; Carcinoma, Small Cell; Disability Evaluation; Drug Evaluation; Etoposide; Female; Humans; Lung Neoplasms; Male; Podophyllotoxin; Recurrence; Remission, Spontaneous; Time Factors | 1978 |
Radiation recall associated with VP-16-213 therapy.
Topics: Carcinoma, Small Cell; Erythema; Etoposide; Female; Humans; Lung Neoplasms; Middle Aged; Podophyllotoxin; Radiation Injuries; Radiation-Sensitizing Agents; Time Factors | 1979 |
Chronic myelomonocytic leukaemia: a case report.
Topics: Aged; Chronic Disease; Etoposide; Humans; Leukemia, Myeloid; Male; Podophyllotoxin | 1977 |
[Clinical and therapeutic study (phase II) using VP-16/213 and methyl-CCNU in patients with inoperable, recurring or metastasizing carcinomas of the gastriointestinal tract].
Topics: Adult; Aged; Colonic Neoplasms; Drug Therapy, Combination; Etoposide; Female; Follow-Up Studies; Humans; Lomustine; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nitrosourea Compounds; Podophyllotoxin; Stomach Neoplasms; Terminal Care; Time Factors | 1978 |
VP-16, cyclophosphamide, adriamycin and cis-platinum (V:CAP-I) in patients with metastatic adenocarcinoma of the lung.
Topics: Adenocarcinoma; Adult; Aged; Bone Marrow; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Podophyllotoxin; Remission, Spontaneous; Time Factors; Vomiting | 1979 |
[Successful therapy of chronic myelomonocytic leukemia with vp 16-213 (author's transl)].
Topics: Age Factors; Aged; Chronic Disease; Etoposide; Granulocytes; Humans; Leukemia; Male; Monocytes; Podophyllotoxin | 1979 |
[Experiences with VP-16 in combination with cyclophosphamide or adriamycin in the anaplastic, predominantly small cell bronchogenic carcinoma].
Topics: Carcinoma, Bronchogenic; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; Humans; Leukopenia; Patient Isolation; Podophyllotoxin | 1979 |
Comparison of a water-soluble and a water-insoluble podophyllotoxin derivative in murine neoplasms.
Topics: Animals; Body Weight; Etoposide; Liver Neoplasms, Experimental; Mice; Neoplasms, Experimental; Podophyllotoxin; Solubility; Water | 1979 |
Lack of severe hypotension with VP-16-213 administered directly lv.
Topics: Adult; Aged; Blood Pressure; Etoposide; Humans; Infusions, Parenteral; Middle Aged; Neoplasms; Podophyllotoxin | 1977 |
Phase II evaluation of VP-16-213 (NSC-141540) in patients with advanced ovarian carcinoma resistant to alkylating agents.
Topics: Alkylating Agents; Alopecia; Drug Evaluation; Drug Resistance; Etoposide; Female; Humans; Nausea; Ovarian Neoplasms; Podophyllotoxin; Vomiting | 1978 |
Evaluation of VP-16-213 in malignant lymphoma and melanoma.
Topics: Adult; Drug Evaluation; Etoposide; Female; Hodgkin Disease; Humans; Lymphoma; Male; Melanoma; Podophyllotoxin | 1978 |
VP-16-213 chemotherapy for advanced squamous cell carcinoma and adenocarcinoma of the lung.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Time Factors | 1978 |
Comparison of uptake and binding of two epipodophyllotoxin glucopyranosides, 4'-demethyl epipodophyllotoxin thenylidene-beta-D-glucoside and 4'-demethyl epipodophyllotoxin ethylidene-beta-D-glucoside, in the L1210 leukemia cell.
Topics: Animals; Binding Sites; Biological Transport; Cell Nucleus; Etoposide; Kinetics; Leukemia L1210; Mice; Mice, Inbred DBA; Podophyllotoxin; Teniposide; Thermodynamics; Vinblastine | 1978 |
Multicompartment pharmacokinetic model of 4'-demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside) in humans.
Topics: Etoposide; Humans; Kinetics; Models, Biological; Podophyllotoxin | 1978 |
Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congeners.
Topics: Animals; Etoposide; In Vitro Techniques; Magnetic Resonance Spectroscopy; Microtubules; Podophyllotoxin; Stereoisomerism; Structure-Activity Relationship; Teniposide; Tubulin | 1978 |
Kinetics of cytotoxicity of VM-26 and VP-16-213 on L1210 leukemia and hematopoietic stem cells.
Topics: Animals; Cell Survival; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Etoposide; Hematopoietic Stem Cells; Leukemia L1210; Podophyllotoxin; Rats; Teniposide; Time Factors | 1978 |
The role of drug disposition kinetics on cellular transport of the antineoplastic agent VM-26.
Topics: Animals; Biological Transport, Active; Chemical Phenomena; Chemistry; Diffusion; Etoposide; Kinetics; Leukemia L1210; Mice; Models, Biological; Podophyllotoxin; Protein Binding; Serum Albumin; Teniposide | 1978 |
Rapid remission induction in adult acute non-lymphoblastic leukaemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Cytarabine; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Humans; Leukemia; Male; Middle Aged; Podophyllotoxin; Remission, Spontaneous; Sepsis; Time Factors | 1978 |
VP 16-213 (VP 16) and cyclophosphamide in the treatment of primitive lung cancer in phase M 1.
Topics: Adult; Aged; Bone Marrow; Cyclophosphamide; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Prednisone; Remission, Spontaneous; Vincristine | 1979 |
[VP 16-213 in combination with endoxan, methotrexate and oncovin as polychemotherapy for bronchogenic carcinoma].
Topics: Adenocarcinoma; Anaplasia; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Etoposide; Humans; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Podophyllotoxin; Remission, Spontaneous; Vincristine | 1977 |
Effect of hemostasis modifiers of the activity of VP 16 213 on Lewis lung carcinoma.
Topics: Animals; Aspirin; Etoposide; Hemostasis; Heparin; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Podophyllotoxin; Transplantation, Homologous | 1977 |
Combination chemotherapy with 4'Demethylepipodophyllotoxin 9-(4,6-0-ethylidene-beta-D-glucopyranoside), VP 16-213 (NSC 141540) in L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Drug Therapy, Combination; Etoposide; Female; Fluorouracil; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred DBA; Podophyllotoxin; Vincristine | 1976 |
Antimetastasis effect of two derivatives of epiposophyllotoxin in mice.
Topics: Animals; Etoposide; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Podophyllotoxin; Solvents; Teniposide; Time Factors | 1976 |
Delayed toxicity of epipodophyllotoxin derivatives (VM 26 and VP 16-213), due to a local effect.
Topics: Animals; Dose-Response Relationship, Drug; Etoposide; Female; Injections, Intraperitoneal; Injections, Intravenous; Leukemia L1210; Liver; Lung; Male; Mice; Organ Size; Podophyllotoxin; Rats; Teniposide; Time Factors | 1976 |
Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in HeLa cells.
Topics: Adenosine; Anthramycin; Choline; Deoxyglucose; Dose-Response Relationship, Drug; Etoposide; Guanosine; HeLa Cells; Leucine; Microtubules; Nucleosides; Podophyllotoxin; Thymidine; Thymine Nucleotides; Tubulin; Uracil Nucleotides; Uridine | 1976 |
Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells.
Topics: Adenoviruses, Human; DNA; DNA, Viral; Dose-Response Relationship, Drug; Etoposide; HeLa Cells; Molecular Weight; Podophyllotoxin; Temperature | 1976 |
PHASE I clinical trial of an oral solution of VP-16-213.
Topics: Antineoplastic Agents; Etoposide; Humans; Podophyllotoxin; Prognosis | 1976 |
Survival and cycle-progression delay of human lymphoma cells in vitro exposed to VP-16-213.
Topics: Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Etoposide; Humans; Lymphoma; Neoplasms, Experimental; Podophyllotoxin | 1976 |
Letter: Epipodophyllotoxin VP 16213 in acute non-lymphoblastic leukaemia.
Topics: Doxorubicin; Drug Therapy, Combination; Etoposide; Humans; Leukemia, Myeloid, Acute; Podophyllotoxin; Thioguanine; Vincristine | 1975 |
[The treatment of acute myelocytic leukemia during the first recurrence by means of a new cytostatic combination].
Topics: Cytarabine; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Etoposide; Humans; Leukemia, Myeloid, Acute; Podophyllotoxin; Thioguanine; Vincristine | 1976 |
Comparison of the human pharmacokinetics of VM-26 and VP-16, two antineoplastic epipodophyllotixin glucopyranoside derivatives.
Topics: Body Water; Etoposide; Humans; Metabolic Clearance Rate; Models, Biological; Neoplasms; Podophyllotoxin; Teniposide | 1975 |
Response of L1210 to combinations of cytosine arabinoside and VM-26 or VP16-213.
Topics: Animals; Cytarabine; Drug Therapy, Combination; Etoposide; Female; Leukemia L1210; Leukemia, Experimental; Mice; Podophyllotoxin; Pyrans; Teniposide | 1975 |
Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4 beta-(arylamino)-4'-O-demethylpodophyllotoxins.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; DNA Damage; Etoposide; Humans; KB Cells; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Succinimides; Topoisomerase II Inhibitors | 1992 |
Antitumor agents. 124. New 4 beta-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II.
Topics: Aniline Compounds; Antineoplastic Agents; Cell Line; Cell Survival; DNA Damage; Etoposide; Humans; KB Cells; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1992 |
Characterization of camptothecin-resistant Chinese hamster lung cells.
Topics: Animals; Base Sequence; Camptothecin; Cell Line; Cricetinae; Cricetulus; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Resistance; Etoposide; Lung; Molecular Sequence Data; Podophyllotoxin; RNA, Messenger; Vincristine | 1992 |
Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Doxorubicin; Etoposide; Heart Rate; In Vitro Techniques; Microtubules; Myocardial Contraction; Nocodazole; Paclitaxel; Podophyllotoxin; Rats; Tubulin; Vinca Alkaloids | 1992 |
Autologous peripheral blood stem cell transplantation after high dose therapy in patients with advanced lymphomas.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion, Autologous; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Etoposide; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Leukapheresis; Lymphoma, Non-Hodgkin; Male; Melphalan; Middle Aged; Podophyllotoxin; Salvage Therapy; Whole-Body Irradiation | 1992 |
[Effects of 4-(4"-(2",2",6",6"-tetramethyl-1"-pipe-ridinyloxy) amino)-4'-demethylepipodophyllotoxin on nucleic acids, proteins, and DNA strand of L7712 cells in vitro].
Topics: Animals; Antineoplastic Agents, Phytogenic; DNA Damage; DNA, Neoplasm; Etoposide; Leukemia, Experimental; Mice; Podophyllotoxin; RNA, Neoplasm; Tumor Cells, Cultured | 1992 |
New perspectives on the toxicity of etoposide.
Topics: Bone Marrow Diseases; Etoposide; Humans; Leukemia; Neoplasms, Second Primary; Podophyllotoxin | 1992 |
Discrimination of mitotic cells using anti-p105 monoclonal antibody to analyze the mode of action of etoposide and podophyllotoxin in human gastric cancer cells.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Cell Cycle; Cell Line; DNA, Neoplasm; Etoposide; Humans; Kinetics; Mitosis; Mitotic Index; Nuclear Proteins; Podophyllotoxin; Proliferating Cell Nuclear Antigen; Stomach Neoplasms | 1991 |
Metal- and photo-induced cleavage of DNA by podophyllotoxin, etoposide, and their related compounds.
Topics: DNA; DNA Damage; DNA, Superhelical; Etoposide; Gallic Acid; Metals; Oxygen; Podophyllotoxin; Ultraviolet Rays | 1991 |
Synthesis and biological activity of galactopyranoside derivatives of 4'-demethylepipodophyllotoxin showing VP-16 (etoposide)-like activity.
Topics: Acetals; Animals; Antineoplastic Agents; CHO Cells; Cricetinae; DNA; DNA Damage; Etoposide; Galactose; Podophyllotoxin; Structure-Activity Relationship; Teniposide | 1991 |
Effect of 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin on human DNA topoisomerase II, tubulin polymerization, KB cells, and their resistant variants.
Topics: DNA Damage; Drug Resistance; Etoposide; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tubulin; Tumor Cells, Cultured | 1991 |
[Application of anti-p-105 monoclonal antibody to analysis of mode of action of antitumor agents].
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Cell Cycle; Etoposide; Humans; Mitosis; Podophyllotoxin; Stomach Neoplasms; Tumor Cells, Cultured | 1991 |
[Antitumor activity of 4-(4''-(2'',2'',6'',6''-tetramethyl-1''-piperidinyoxy)amino)-4'- demethyl epipodophyllotoxin in vitro].
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Etoposide; Humans; Microtubule-Associated Proteins; Mitotic Index; Podophyllotoxin; Stomach Neoplasms; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1990 |
Tests for the genotoxicity of m-AMSA, etoposide, teniposide and ellipticine in Neurospora crassa.
Topics: Alkaloids; Amsacrine; Ellipticines; Etoposide; Molecular Structure; Mutagenicity Tests; Mutagens; Neurospora crassa; Podophyllotoxin; Teniposide | 1990 |
Reduction of drug accumulation and DNA topoisomerase II activity in acquired teniposide-resistant human cancer KB cell lines.
Topics: DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance; Etoposide; Humans; KB Cells; Podophyllotoxin; Temperature; Teniposide | 1990 |
Pharmacokinetics of intrapleural versus intravenous etoposide (VP 16) and teniposide (VM 26) in patients with malignant pleural effusion.
Topics: Aged; Etoposide; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Pleural Effusion; Podophyllotoxin; Teniposide | 1990 |
Partitioning of teniposide into membranes and the role of lipid composition.
Topics: Etoposide; Kinetics; Lipid Bilayers; Models, Biological; Phosphatidylcholines; Podophyllotoxin; Structure-Activity Relationship; Teniposide; Tritium | 1990 |
Effects of the lipophilic anticancer drug teniposide (VM-26) on membrane transport.
Topics: Amino Acids; Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Carrier Proteins; Cell Membrane; Cell Membrane Permeability; Cytarabine; Etoposide; Humans; Membrane Lipids; Membranes, Artificial; Nucleosides; Podophyllotoxin; Teniposide; Tumor Cells, Cultured | 1990 |
[Kinetics of etoposide cytotoxicity against mouse P388 leukemia].
Topics: Animals; Bleomycin; Cell Cycle; Cell Survival; Cisplatin; Colony-Forming Units Assay; Cytarabine; Doxorubicin; Etoposide; Fluorouracil; Leukemia P388; Leukemia, Experimental; Melphalan; Mice; Peplomycin; Podophyllotoxin; Tumor Stem Cell Assay; Vinblastine | 1985 |
Pharmacological purging of bone marrow with drugs other than cyclophosphamide derivatives.
Topics: Animals; Antineoplastic Agents; Bleomycin; Bone Marrow; Cell Line; Cell Separation; Etoposide; Hematopoietic Stem Cells; Leukemia L1210; Leukemia, Experimental; Mice; Mice, Inbred C57BL; Podophyllotoxin | 1985 |
[Complete remission obtained in advanced testicular cancer treated by etoposide (NK-171)].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Etoposide; Humans; Lung Neoplasms; Lymph Node Excision; Male; Peplomycin; Podophyllotoxin; Teratoma; Testicular Neoplasms; Vincristine | 1986 |
VP-16-213 (etoposide) in the management of germinal testis tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Etoposide; Humans; Male; Middle Aged; Neoplasms, Germ Cell and Embryonal; Podophyllotoxin; Testicular Neoplasms; Vinblastine | 1985 |
Hypersensitivity of cultured ataxia-telangiectasia cells to etoposide.
Topics: Aminoacridines; Amsacrine; Ataxia Telangiectasia; Bleomycin; Cell Survival; Cells, Cultured; DNA; Etoposide; Fibroblasts; Humans; Podophyllotoxin | 1986 |
Synthesis of 18F-labelled VP 16-213 and podophyllotoxin using acetyl hypofluorite.
Topics: Acetates; Esters; Etoposide; Fluorine; Fluorine Radioisotopes; Isotope Labeling; Molecular Conformation; Podophyllotoxin | 1989 |
Topoisomerase II: a potential target for novel antifungal agents.
Topics: Amiloride; Amsacrine; Antifungal Agents; DNA, Superhelical; Etoposide; Molecular Structure; Novobiocin; Plasmids; Podophyllotoxin; Saccharomyces cerevisiae; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1989 |
Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants.
Topics: DNA Damage; Drug Resistance; Etoposide; Humans; KB Cells; Podophyllotoxin; Polymers; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tubulin | 1989 |
Altered formation of DNA in human cells treated with inhibitors of DNA topoisomerase II (etoposide and teniposide).
Topics: DNA Replication; DNA, Neoplasm; Etoposide; Humans; Kinetics; Melanoma; Podophyllotoxin; Teniposide; Thymidine; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1989 |
Expression of protein-associated DNA damage in the alkaline elution assay in the absence of enzymatic deproteinization.
Topics: Animals; Cell Line; DNA Damage; DNA Replication; DNA Topoisomerases, Type II; DNA, Neoplasm; Endopeptidase K; Etoposide; Humans; Hydrogen-Ion Concentration; Leukemia L1210; Liver Neoplasms, Experimental; Mice; Mitoxantrone; Podophyllotoxin; Protein Binding; Rats; Serine Endopeptidases; Teniposide; Tumor Cells, Cultured | 1989 |
Anaphylactic reactions to teniposide.
Topics: Adolescent; Anaphylaxis; Child; Child, Preschool; Etoposide; Humans; Infusions, Intravenous; Podophyllotoxin; Teniposide | 1989 |
VP-16 in combinations for first-line treatment of malignant germ-cell tumors and gestational choriocarcinoma.
Topics: alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Choriocarcinoma; Chorionic Gonadotropin; Cyclophosphamide; Cytarabine; Dactinomycin; Etoposide; Female; Humans; Male; Methotrexate; Neoplasms, Germ Cell and Embryonal; Podophyllotoxin; Pregnancy; Uterine Neoplasms; Vincristine | 1985 |
[VM-26 and VP-16 salvage therapy for refractory germinal testicular cancers].
Topics: Adult; Choriocarcinoma; Dysgerminoma; Etoposide; Humans; Male; Middle Aged; Podophyllotoxin; Teniposide; Teratoma; Testicular Neoplasms | 1989 |
Automated reversed-phase chromatographic analysis of etoposide and teniposide in plasma by using on-line surfactant-mediated sample clean-up and column-switching.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Etoposide; Humans; Podophyllotoxin; Spectrometry, Fluorescence; Teniposide | 1989 |
[Podophyllic acid piperidyl hydrazone nitroxide radical and etoposide on nucleic acids and protein metabolism of leukemia L7712 cells in vitro].
Topics: Adenosine Triphosphate; Animals; DNA, Neoplasm; Etoposide; Leukemia, Experimental; Mice; Neoplasm Proteins; Podophyllotoxin; RNA, Neoplasm; Tumor Cells, Cultured | 1989 |
Treatment strategies in relation to drug action.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; DNA Topoisomerases, Type II; Etoposide; Hodgkin Disease; Humans; Leukemia; Lung Neoplasms; Lymphoma, Non-Hodgkin; Neoplasms; Podophyllotoxin; Teniposide | 1987 |
Topoisomerase-II-mediated lesions in nascent DNA: comparison of the effects of epipodophyllotoxin derivatives, VM-26 and VP-16, and 9-anilinoacridine derivatives, m-AMSA and o-AMSA.
Topics: Adenosine Triphosphate; Amsacrine; Animals; Cross-Linking Reagents; DNA; DNA Damage; DNA Replication; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Leukemia L1210; Mice; Novobiocin; Podophyllotoxin; Teniposide; Topoisomerase II Inhibitors | 1988 |
DNA binding by epipodophyllotoxins and N-acyl anthracyclines: implications for mechanism of topoisomerase II inhibition.
Topics: Antibiotics, Antineoplastic; DNA; DNA, Mitochondrial; Etoposide; In Vitro Techniques; Plasmids; Podophyllotoxin; Teniposide; Topoisomerase II Inhibitors | 1988 |
Podophyllotoxins for brain metastases of small cell lung cancer.
Topics: Brain Neoplasms; Carcinoma, Small Cell; Etoposide; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Teniposide | 1988 |
Effects of microtubule inhibitors on etoposide accumulation and DNA damage in human K562 cells in vitro.
Topics: Alkaloids; Cell Line; Colchicine; DNA; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Humans; In Vitro Techniques; Maytansine; Microtubules; Paclitaxel; Podophyllotoxin; Time Factors; Vinblastine | 1987 |
Combined thin layer chromatography/mass spectrometry: an application of 252Cf plasma desorption mass spectrometry for drug monitoring.
Topics: Californium; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Etoposide; Humans; Kinetics; Mass Spectrometry; Podophyllotoxin | 1985 |
Inactivation of phi X174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213.
Topics: Bacteriophage phi X 174; DNA, Single-Stranded; DNA, Viral; Etoposide; NADP; Podophyllotoxin | 1985 |
Multicenter Phase II trial of etoposide in refractory small cell lung cancer.
Topics: Carcinoma, Small Cell; Drug Evaluation; Etoposide; Female; Humans; Leukopenia; Lung Neoplasms; Male; Multi-Institutional Systems; Nausea; Podophyllotoxin; Vomiting | 1985 |
Pharmacokinetics of etoposide in gestochoriocarcinoma.
Topics: Choriocarcinoma; Etoposide; Female; Half-Life; Humans; Kinetics; Lung; Lung Neoplasms; Myometrium; Podophyllotoxin; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms | 1985 |
Extensive-stage small-cell bronchogenic carcinoma: intensive induction chemotherapy with high-dose cyclophosphamide plus high-dose etoposide.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Leukopenia; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Pilot Projects; Podophyllotoxin; Thrombocytopenia; Vincristine | 1985 |
Late intensification in small-cell lung cancer: a phase I study of high doses of cyclophosphamide and etoposide with autologous bone marrow transplantation.
Topics: Adrenal Gland Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Transplantation; Carcinoma, Small Cell; Cyclophosphamide; Drug Evaluation; Etoposide; Female; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Podophyllotoxin | 1985 |
Probable cure of small cell carcinoma of the lung by etoposide.
Topics: Carcinoma, Small Cell; Etoposide; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Radiography; Smoking | 1985 |
The role of VP-16 in the treatment of small-cell lung cancer: studies of the West of Scotland Lung Cancer Group.
Topics: Carcinoma, Small Cell; Cyclophosphamide; Drug Resistance; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Verapamil | 1985 |
High-dose etoposide (VP-16) in small-cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Etoposide; Humans; Lung Neoplasms; Middle Aged; Podophyllotoxin | 1985 |
Single-dose etoposide in combination with vincristine and doxorubicin in the treatment of small-cell lung cancer (SCLC).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Doxorubicin; Etoposide; Humans; Lung Neoplasms; Middle Aged; Podophyllotoxin; Vincristine | 1985 |
Role of etoposide-based chemotherapy in the treatment of patients with refractory or relapsing germ cell tumors.
Topics: Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Dysgerminoma; Etoposide; Female; Fever; Follow-Up Studies; Humans; Male; Nausea; Neoplasm Recurrence, Local; Neoplasms, Germ Cell and Embryonal; Podophyllotoxin; Prognosis; Teratoma | 1985 |
Ovarian dysfunction in patients with gestational trophoblastic neoplasia treated with short intensive courses of etoposide (VP-16-213).
Topics: Adult; Amenorrhea; Chorionic Gonadotropin; Estradiol; Etoposide; Female; Follicle Stimulating Hormone; Humans; Middle Aged; Ovary; Ovulation; Podophyllotoxin; Pregnancy; Progesterone; Prolactin; Prospective Studies; Trophoblastic Neoplasms; Uterine Neoplasms | 1985 |
Etoposide and cisplatin salvage chemotherapy for small cell lung cancer.
Topics: Aged; Carcinoma, Small Cell; Cisplatin; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Humans; Injections, Intravenous; Leukocyte Count; Male; Middle Aged; Neoplasm Metastasis; Platelet Count; Podophyllotoxin | 1985 |
Bone marrow morphologic changes after combination chemotherapy including VP-16.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carcinoma, Small Cell; Cyclophosphamide; Doxorubicin; Erythrocytes; Etoposide; Female; Hematopoiesis; Humans; Lung Neoplasms; Male; Mitosis; Podophyllotoxin; Vincristine | 1985 |
Inhibition of epipodophyllotoxin cytotoxicity by interference with topoisomerase-mediated DNA cleavage.
Topics: Animals; Cell Survival; DNA; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Ethidium; Etoposide; Leukemia L1210; Mice; Podophyllotoxin | 1985 |
Drug monitoring of etoposide (VP16-213). I. A combined method of liquid chromatography and mass spectrometry.
Topics: Californium; Carcinoma, Small Cell; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Computers; Etoposide; Half-Life; Humans; Kinetics; Lung Neoplasms; Mass Spectrometry; Podophyllotoxin | 1985 |
Etoposide.
Topics: Brain Neoplasms; Etoposide; Female; Humans; Podophyllotoxin; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms | 1985 |
[A phase II study of oral VP-16 in primary lung cancer].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Anorexia; Capsules; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nausea; Podophyllotoxin | 1985 |
The effect of food and concurrent chemotherapy on the bioavailability of oral etoposide.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Carcinoma, Small Cell; Drug Interactions; Etoposide; Food; Humans; Kinetics; Lung Neoplasms; Podophyllotoxin | 1985 |
[A phase II study of NK171 (etoposide)].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Alopecia; Anorexia; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Infusions, Parenteral; Leukopenia; Lung Neoplasms; Male; Middle Aged; Nausea; Podophyllotoxin | 1985 |
Identification of DNA topoisomerase II as an intracellular target of antitumor epipodophyllotoxins in simian virus 40-infected monkey cells.
Topics: Animals; Cells, Cultured; Chemical Precipitation; DNA Topoisomerases, Type II; DNA, Viral; Etoposide; Haplorhini; Novobiocin; Podophyllotoxin; Simian virus 40; Teniposide | 1985 |
High-dose cyclophosphamide and VP 16 as late dosage intensification therapy for small cell carcinoma of lung.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carcinoma, Small Cell; Cyclophosphamide; Etoposide; Follow-Up Studies; Humans; Lung Neoplasms; Podophyllotoxin | 1985 |
[A phase II study of etoposide (NK 171) in small cell lung cancer--comparison of results between intravenous administration and oral administration].
Topics: Administration, Oral; Adult; Aged; Alopecia; Anorexia; Carcinoma, Small Cell; Drug Evaluation; Etoposide; Fatigue; Female; Humans; Infusions, Parenteral; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1985 |
Variable bioavailability following repeated oral doses of etoposide.
Topics: Adult; Biological Availability; Carcinoma, Small Cell; Drug Administration Schedule; Etoposide; Humans; Kinetics; Lung Neoplasms; Mesothelioma; Podophyllotoxin; Time Factors | 1985 |
[A phase II study of etoposide (VP-16) injection in primary lung cancer by cooperative study group].
Topics: Adenocarcinoma; Adult; Aged; Alopecia; Anorexia; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Injections; Lung Neoplasms; Male; Middle Aged; Nausea; Podophyllotoxin | 1986 |
Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity.
Topics: Aminoacridines; Amsacrine; Animals; Cell Line; Cricetinae; Cricetulus; DNA; DNA Topoisomerases, Type II; Drug Resistance; Etoposide; Female; Ovary; Podophyllotoxin | 1986 |
Pharmacokinetic evaluation of increasing dosages of etoposide in a chronic hemodialysis patient.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Chromatography, High Pressure Liquid; Cyclophosphamide; Doxorubicin; Etoposide; Humans; Kidney Failure, Chronic; Kinetics; Lung Neoplasms; Male; Mathematics; Middle Aged; Podophyllotoxin; Renal Dialysis | 1985 |
The effect of dose on the bioavailability of oral etoposide.
Topics: Administration, Oral; Adult; Biological Availability; Carcinoma, Small Cell; Chromatography, High Pressure Liquid; Etoposide; Half-Life; Humans; Kinetics; Mesothelioma; Podophyllotoxin; Random Allocation | 1986 |
Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26).
Topics: Chromatography, High Pressure Liquid; Electron Spin Resonance Spectroscopy; Etoposide; Free Radicals; Horseradish Peroxidase; Mass Spectrometry; Oxidoreductases, O-Demethylating; Peroxides; Podophyllotoxin; Prostaglandin-Endoperoxide Synthases; Quinones; Teniposide | 1986 |
[A phase II study of intravenous VP-16-213 in small cell and non-small cell carcinoma of the lung].
Topics: Adult; Aged; Alopecia; Carcinoma, Small Cell; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Infusions, Parenteral; Lung Neoplasms; Male; Middle Aged; Nausea; Podophyllotoxin | 1986 |
[Phase II study of etoposide in patients with lung cancer, with special reference to small cell carcinoma].
Topics: Adenocarcinoma; Aged; Carcinoma, Small Cell; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1986 |
[Phase II study of VP-16 in patients with primary bronchogenic carcinoma, with special reference to small cell carcinoma--a multi-institutional cooperative study].
Topics: Administration, Oral; Aged; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1986 |
Proliferation dependence of topoisomerase II mediated drug action.
Topics: Aminoacridines; Amsacrine; Animals; Cell Line; Cricetinae; Cricetulus; DNA Replication; DNA Topoisomerases, Type II; Etoposide; Female; HeLa Cells; Humans; Intercalating Agents; Kinetics; Leukemia L1210; Mice; Ovary; Plasmids; Podophyllotoxin | 1986 |
Primary oral etoposide therapy in gestational trophoblastic disease. An update.
Topics: Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Chorionic Gonadotropin; Etoposide; Female; Humans; Hydatidiform Mole; Hysterectomy; Lung Neoplasms; Neoplasm Recurrence, Local; Podophyllotoxin; Pregnancy; Risk; Trophoblastic Neoplasms; Uterine Neoplasms; Vaginal Neoplasms | 1986 |
DNA breakage in human lung carcinoma cells and nuclei that are naturally sensitive or resistant to etoposide and teniposide.
Topics: Adenocarcinoma; Adenosine Triphosphate; Carcinoma, Small Cell; Cell Division; Cell Nucleus; Cells, Cultured; DNA; DNA, Single-Stranded; Drug Resistance; Etoposide; Humans; Intercalating Agents; Lung Neoplasms; Podophyllotoxin; Teniposide; Topoisomerase II Inhibitors | 1986 |
Modulation of etoposide cytotoxicity and DNA strand scission in L1210 and 8226 cells by polyamines.
Topics: Animals; Cell Survival; DNA Topoisomerases, Type II; DNA, Neoplasm; DNA, Single-Stranded; Eflornithine; Etoposide; Humans; Leukemia L1210; Mice; Multiple Myeloma; Nucleic Acid Conformation; Ornithine; Podophyllotoxin; Polyamines; Putrescine | 1986 |
High-dose etoposide with autologous bone marrow transplantation as initial treatment of small cell lung cancer--a negative report.
Topics: Bone Marrow Diseases; Bone Marrow Transplantation; Carcinoma, Small Cell; Combined Modality Therapy; Etoposide; Humans; Lung Neoplasms; Middle Aged; Mouth Mucosa; Podophyllotoxin; Stomatitis; Transplantation, Autologous | 1986 |
Etoposide: a pharmacokinetic profile including an assessment of bioavailability.
Topics: Administration, Oral; Biological Availability; Carcinoma; Carcinoma, Small Cell; Etoposide; Female; Hodgkin Disease; Humans; Injections, Intravenous; Kinetics; Lung Neoplasms; Lymphoma; Male; Neoplasms; Podophyllotoxin | 1986 |
Membrane ordering effects of the anticancer agent VM-26.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cell Membrane; Cholesterol; Cyclic N-Oxides; Dimyristoylphosphatidylcholine; Electron Spin Resonance Spectroscopy; Etoposide; Humans; Leukemia; Lipid Bilayers; Liposomes; Male; Membrane Lipids; Mice; Podophyllotoxin; Spin Labels; Teniposide | 1986 |
Cyclophosphamide, etoposide, and infusion cisplatin in refractory small cell lung cancer. A preliminary report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Vincristine | 1987 |
Protein-linked DNA strand breaks produced by etoposide and teniposide in mouse L1210 and human VA-13 and HT-29 cell lines: relationship to cytotoxicity.
Topics: Animals; Cell Line; Cell Survival; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Humans; Kinetics; Leukemia L1210; Podophyllotoxin; Teniposide | 1987 |
Cytogenetic effects of etoposide (VP-16) on human lymphocytes; with special reference to the relation between sister chromatid exchange and chromatid breakage.
Topics: Cells, Cultured; Chromosome Aberrations; Etoposide; Humans; Karyotyping; Lymphocytes; Podophyllotoxin; Sister Chromatid Exchange | 1986 |
Structure-bioactivation relationship of a series of podophyllotoxin derivatives.
Topics: Animals; Cell Survival; Cytochrome P-450 Enzyme System; Etoposide; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Podophyllotoxin; Rats; Rats, Inbred Strains; Spectrophotometry; Structure-Activity Relationship; Teniposide | 1988 |
Ifosfamide and VP-16213 combination chemotherapy combined with ablative chemotherapy and autologous marrow transplantation as salvage treatment for malignant lymphoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Combined Modality Therapy; Cytarabine; Etoposide; Humans; Ifosfamide; Lymphoma; Melphalan; Methotrexate; Middle Aged; Mitoguazone; Podophyllotoxin | 1988 |
Etoposide (VP16) and teniposide (VM26): novel anticancer drugs, strongly mutagenic in mammalian but not prokaryotic test systems.
Topics: Animals; Cell Line; Escherichia coli; Etoposide; Hypoxanthine Phosphoribosyltransferase; L Cells; Mice; Mutagenicity Tests; Mutagens; Mutation; Podophyllotoxin; Salmonella typhimurium; Teniposide | 1987 |
Synthesis and structure-activity relationships among glycosidic derivatives of 4'-demethylepipodophyllotoxin and epipodophyllotoxin, showing VM26- and VP16-213-like activities.
Topics: Antineoplastic Agents; Cell Line; Drug Resistance; Etoposide; Podophyllotoxin; Structure-Activity Relationship; Teniposide | 1987 |
Synthesis and biological activities of the C-4 esters of 4'-demethylepipodophyllotoxin.
Topics: Antineoplastic Agents; Cell Line; Drug Resistance; Esters; Etoposide; Mitotic Index; Podophyllotoxin; Structure-Activity Relationship; Teniposide | 1987 |
Verapamil potentiation of VP-16-213 in acute lymphatic leukemia and reversal of pleiotropic drug resistance.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Etoposide; Humans; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Leukemia, Lymphoid; Mice; Podophyllotoxin; Verapamil; Vincristine | 1986 |
Simple method for the administration of high-dose etoposide during autologous bone marrow transplantation.
Topics: Adult; Aged; Bone Marrow Transplantation; Drug Evaluation; Etoposide; Humans; Infusions, Parenteral; Leukemia; Lung Neoplasms; Middle Aged; Podophyllotoxin | 1986 |
Etoposide as an in vitro purging agent for the treatment of acute leukemias and lymphomas in conjunction with autologous bone marrow transplantation.
Topics: Bone Marrow; Bone Marrow Transplantation; Colony-Forming Units Assay; Etoposide; Hematopoietic Stem Cells; Humans; Leukemia; Lymphoma; Microscopy, Electron; Podophyllotoxin; Transplantation, Autologous | 1986 |
Non-Hodgkin's lymphomas in the elderly: prospective studies with specifically devised chemotherapy regimens in 66 patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Etoposide; Female; Humans; Lymphoma, Non-Hodgkin; Male; Podophyllotoxin; Prednimustine; Prospective Studies; Teniposide | 1987 |
Pharmacokinetics of etoposide in patients with abnormal renal and hepatic function.
Topics: Adult; Aged; Etoposide; Female; Humans; Kidney Diseases; Liver Diseases; Male; Metabolic Clearance Rate; Middle Aged; Podophyllotoxin | 1986 |
Clinical pharmacology of intracarotid etoposide.
Topics: Brain; Carotid Arteries; Etoposide; Half-Life; Humans; Injections, Intra-Arterial; Kinetics; Podophyllotoxin | 1986 |
Influence of polysorbate 80 (Tween 80) and etoposide (VP-16-213) on the pharmacokinetics and urinary excretion of adriamycin and its metabolites in cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Interactions; Etoposide; Female; Humans; Kinetics; Male; Middle Aged; Neoplasms; Pharmaceutical Vehicles; Podophyllotoxin; Polysorbates | 1986 |
Comparison between VP 16 and VM 26 in Lewis lung carcinoma of the mouse.
Topics: Animals; Body Weight; Cell Count; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Etoposide; Kinetics; Leukocyte Count; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Podophyllotoxin; Teniposide | 1986 |
Quantification of teniposide in human serum by high-performance liquid chromatography with electrochemical detection.
Topics: Carcinoma; Chromatography, High Pressure Liquid; Electrochemistry; Etoposide; Female; Humans; Indicators and Reagents; Ovarian Neoplasms; Podophyllotoxin; Teniposide; Time Factors | 1986 |
Physiological and electrophysiological consequences of etoposide-induced blood-brain barrier disruption.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain; Electroencephalography; Electrophysiology; Etoposide; Female; Intracranial Pressure; Podophyllotoxin; Rats; Rats, Inbred Strains | 1986 |
Multifocal eosinophilic granuloma. Response of a patient to etoposide.
Topics: Eosinophilic Granuloma; Etoposide; Humans; Lymphography; Male; Middle Aged; Podophyllotoxin; Tomography, X-Ray Computed | 1986 |
Etoposide (VP-16) plus cisplatin (DDP): a new active chemotherapeutic combination in patients with stage III-IV ovarian adenocarcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cystadenocarcinoma; Etoposide; Female; Humans; Middle Aged; Ovarian Neoplasms; Podophyllotoxin; Prognosis | 1986 |
[Etoposide in the treatment of recurrent malignant lymphoma].
Topics: Adolescent; Adult; Aged; Etoposide; Hodgkin Disease; Humans; Lymphoma; Middle Aged; Neoplasm Recurrence, Local; Podophyllotoxin | 1986 |
[Phase II study of etoposide (VP-16-213) in genitourinary tumors. VP-16-213 Genitourinary Study Group].
Topics: Adult; Aged; Alopecia; Anorexia; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Male; Middle Aged; Nausea; Podophyllotoxin; Prostatic Neoplasms; Testicular Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms | 1986 |
[Combination of etoposide with cisplatin or cyclophosphamide in the treatment of mouse Lewis lung carcinoma].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Drug Synergism; Etoposide; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Podophyllotoxin | 1986 |
[Mutagenicity tests of etoposide and teniposide].
Topics: Animals; Etoposide; Male; Mice; Mutagenicity Tests; Podophyllotoxin; Teniposide | 1986 |
Studies on lignan lactone antitumor agents. I. Synthesis of aminoglycosidic lignan variants related to podophyllotoxin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Etoposide; Leukemia L1210; Mice; Podophyllotoxin | 1986 |
Studies on lignan lactone antitumor agents. II. Synthesis of N-alkylamino- and 2,6-dideoxy-2-aminoglycoside lignan variants related to podophyllotoxin.
Topics: Aminoglycosides; Animals; Antineoplastic Agents, Phytogenic; Etoposide; Leukemia L1210; Mice; Podophyllotoxin | 1986 |
The effect of the two epipodophyllotoxin derivatives etoposide (VP-16) and teniposide (VM-26) on cell lines established from patients with small cell carcinoma of the lung.
Topics: Animals; Carcinoma, Squamous Cell; Cell Cycle; Cell Line; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Etoposide; Lung Neoplasms; Podophyllotoxin; Teniposide | 1987 |
Etoposide-induced hypersensitivity reactions. Report of two cases.
Topics: Bronchial Spasm; Drug Hypersensitivity; Etoposide; Female; Flushing; Humans; Hypotension; Male; Middle Aged; Podophyllotoxin | 1985 |
Etoposide prior to cis-diamminedichloroplatinum in combination chemotherapy: in vitro and in vivo studies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Etoposide; Lung Neoplasms; Mice; Mice, Inbred C57BL; Podophyllotoxin | 1985 |
[A phase II trial of etoposide (VP-16) administered intravenously in the treatment of malignant lymphoma and acute leukemia].
Topics: Acute Disease; Adolescent; Adult; Aged; Drug Evaluation; Etoposide; Female; Humans; Infusions, Parenteral; Leukemia; Lymphoma; Male; Middle Aged; Podophyllotoxin | 1985 |
Single- and double-strand DNA breakage and repair in human lung adenocarcinoma cells exposed to etoposide and teniposide.
Topics: Adenocarcinoma; Aminoacridines; Amsacrine; Cells, Cultured; DNA; DNA Repair; Etoposide; Humans; Lung Neoplasms; Podophyllotoxin; Teniposide | 1985 |
Amsacrine and etoposide induced paralytic ileus in a patient with acute myelomonocytic leukemia.
Topics: Aged; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Humans; Leukemia, Myeloid, Acute; Male; Podophyllotoxin | 1985 |
Synergistic effect of 4-hydroperoxycyclophosphamide and etoposide on a human promyelocytic leukemia cell line (HL-60) demonstrated by computer analysis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line; Computers; Cyclophosphamide; Drug Synergism; Etoposide; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Podophyllotoxin | 1985 |
Effects of verapamil on etoposide, vincristine, and adriamycin activity in normal human bone marrow granulocyte-macrophage progenitors and in human K562 leukemia cells in vitro.
Topics: Bone Marrow; Cell Survival; Cells, Cultured; Doxorubicin; Drug Synergism; Etoposide; Granulocytes; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid; Macrophages; Podophyllotoxin; Verapamil; Vincristine | 1985 |
[VP 16-213].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Doxorubicin; Drug Evaluation; Etoposide; Humans; Leucovorin; Lymphoma; Methotrexate; Podophyllotoxin; Prednisolone | 1985 |
When is autologous bone marrow transplantation safe after high-dose treatment with etoposide?
Topics: Adult; Aged; Bone Marrow; Bone Marrow Transplantation; Cyclophosphamide; Etoposide; Female; Humans; Infusions, Parenteral; Lung Neoplasms; Male; Middle Aged; Neutrophils; Podophyllotoxin; Reticulocytes; Time Factors; Transplantation, Autologous | 1985 |
Effect of oxygen on the cytotoxicity and antitumor activity of etoposide.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Carbon Dioxide; Cell Line; Cell Survival; Drug Combinations; Drug Interactions; Etoposide; Fibrosarcoma; Fluorocarbons; Hydroxyethyl Starch Derivatives; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Oxygen; Podophyllotoxin; Tumor Stem Cell Assay | 1985 |
Use of VP-16-213 in the treatment of familial erythrophagocytic lymphohistiocytosis.
Topics: Child, Preschool; Etoposide; Female; Follow-Up Studies; Humans; Infant; Lymphatic Diseases; Male; Nervous System Neoplasms; Podophyllotoxin | 1986 |
[A phase I study of VP-16-213 (VP, etoposide) by single and 5-day intravenous administration].
Topics: Adult; Aged; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Infusions, Parenteral; Kinetics; Leukopenia; Male; Middle Aged; Neoplasms; Podophyllotoxin; Thrombocytopenia | 1986 |
Ifosfamide and etoposide as salvage therapy for non-Hodgkin's lymphoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Etoposide; Humans; Ifosfamide; Lymphoma; Methotrexate; Podophyllotoxin; Recurrence | 1986 |
[Phase II study of NK 171 (etoposide) on malignant lymphomas and acute leukemia. A cooperative study group on NK 171 in hematological malignancies].
Topics: Acute Disease; Adolescent; Adult; Aged; Alopecia; Anorexia; Drug Evaluation; Etoposide; Fatigue; Female; Humans; Leukemia; Lymphoma; Male; Middle Aged; Nausea; Podophyllotoxin | 1986 |
MACC (methotrexate, doxorubicin, cyclophosphamide and lomustine) versus cis-platinum and etoposide in the treatment of advanced non-small cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Lomustine; Lung Neoplasms; Male; Methotrexate; Middle Aged; Podophyllotoxin; Time Factors | 1986 |
[Antitumor effects of a podophyllotoxin derivative, VP 16-213].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Female; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Podophyllotoxin | 1986 |
[General pharmacological studies of VP 16-213. Effect on the peripheral system].
Topics: Animals; Anti-Inflammatory Agents; Blood Coagulation; Blood Glucose; Conjunctiva; Dogs; Etoposide; Female; Guinea Pigs; Immunosuppressive Agents; Intestinal Mucosa; Kidney; Liver; Male; Muscle, Smooth; Peripheral Nerves; Podophyllotoxin; Rabbits; Rats; Rats, Inbred Strains | 1986 |
[Etoposide (VP 16/NK 171) and cytosine arabinoside combination chemotherapy in refractory childhood leukemia].
Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Drug Administration Schedule; Etoposide; Female; Humans; Infant; Leukemia; Lymphoma; Male; Myeloproliferative Disorders; Podophyllotoxin | 1986 |
Etoposide in the treatment of multifocal eosinophilic granuloma.
Topics: Bone Diseases; Eosinophilic Granuloma; Etoposide; Female; Gingival Diseases; Humans; Middle Aged; Podophyllotoxin; Recurrence; Vulvar Diseases | 1985 |
A case report and description of the pharmacokinetic behavior of intrapleurally instilled etoposide.
Topics: Absorption; Chromatography, High Pressure Liquid; Diffusion; Etoposide; Female; Humans; Kinetics; Lymphoma; Middle Aged; Pleural Effusion; Podophyllotoxin | 1985 |
VP-16 in the treatment of malignant lymphomas: a report from the Swiss Group for Clinical Cancer Research (SAKK).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Etoposide; Humans; Lymphoma; Middle Aged; Pilot Projects; Podophyllotoxin | 1985 |
Bioavailability and pharmacokinetics of etoposide (VP-16).
Topics: Aged; Biological Availability; Etoposide; Female; Humans; Kinetics; Male; Middle Aged; Podophyllotoxin | 1985 |
Verapamil-induced augmentation of etoposide accumulation in L1210 cells in vitro.
Topics: Animals; Cells, Cultured; DNA Repair; Drug Synergism; Etoposide; Leukemia L1210; Mice; Podophyllotoxin; Tritium; Verapamil | 1985 |
Stability-indicating liquid chromatographic determination of etoposide and benzyl alcohol in injectable formulations.
Topics: Benzaldehydes; Benzyl Alcohol; Benzyl Alcohols; Benzyl Compounds; Chromatography, High Pressure Liquid; Drug Compounding; Drug Stability; Etoposide; Injections; Podophyllotoxin; Spectrophotometry, Ultraviolet | 1985 |
The Kidney Invasion Test: an assay allowing macroscopic quantification of malignant invasion in vivo. Comparison between the microtubule inhibitor tubulozole and the podophyllotoxin congener etoposide (VP-16-213).
Topics: Animals; Cell Division; Dioxolanes; Dioxoles; Drug Evaluation, Preclinical; Etoposide; Kidney Neoplasms; Male; Mice; Neoplasm Invasiveness; Neoplasm Transplantation; Podophyllotoxin | 1985 |
[Effect of etoposide for urogenital tumors].
Topics: Adenocarcinoma; Adenocarcinoma, Papillary; Aged; Antineoplastic Agents, Phytogenic; Drug Administration Schedule; Etoposide; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Pancreatic Neoplasms; Podophyllotoxin; Prostatic Neoplasms; Rhabdomyosarcoma; Ureteral Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms | 1985 |
Microsomal interactions and inhibition of lipid peroxidation by etoposide (VP-16, 213): implications for mode of action.
Topics: Animals; Daunorubicin; Etoposide; Free Radicals; Lipid Peroxides; Mice; Microsomes, Liver; NADP; Oxygen Consumption; Podophyllotoxin | 1985 |
Inhibition of 1-beta-D-arabinofuranosylcytosine transport and net accumulation by teniposide and etoposide in Ehrlich ascites cells and human leukemic blasts.
Topics: Animals; Binding Sites; Biological Transport; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cytarabine; Etoposide; Humans; Leukemia; Male; Mice; Mice, Inbred Strains; Podophyllotoxin; Teniposide; Thioinosine; Tritium | 1985 |
High-performance liquid chromatography of etoposide in plasma and urine.
Topics: Chromatography, High Pressure Liquid; Etoposide; Humans; Podophyllotoxin; Spectrophotometry, Ultraviolet | 1985 |
[Phase II study of etoposide (VP-16) in the form of oral capsules for malignant lymphomas].
Topics: Administration, Oral; Adult; Aged; Capsules; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Leukopenia; Lymphoma; Male; Middle Aged; Podophyllotoxin; Thrombocytopenia | 1985 |
High-dose etoposide in the treatment of relapsed primary brain tumors.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Etoposide; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Podophyllotoxin | 1985 |
Metabolic studies of a podophyllotoxin derivative (VP16) in the isolated perfused liver.
Topics: Animals; Bile; Etoposide; In Vitro Techniques; Isomerism; Kinetics; Liver; Male; Mass Spectrometry; Perfusion; Podophyllotoxin; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1985 |
Transient heart block. An unreported toxicity of high dose chemotherapy with cyclophosphamide and etoposide.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Electrocardiography; Etoposide; Heart Block; Humans; Male; Middle Aged; Podophyllotoxin | 1985 |
Pharmacokinetics and toxicity of the epipodophyllotoxin derivative etoposide (VP 16-213) in patients with gestational choriocarcinoma and malignant teratoma.
Topics: Choriocarcinoma; Cyclophosphamide; Drug Administration Schedule; Etoposide; Female; Humans; Male; Podophyllotoxin; Pregnancy; Teratoma; Testicular Neoplasms; Time Factors; Uterine Neoplasms | 1985 |
[Collaborative phase II study of etoposide (NK-171). Urological Cooperative Study Group of etoposide (NK-171)].
Topics: Administration, Oral; Alopecia; Anorexia; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Infusions, Parenteral; Kidney Neoplasms; Male; Nausea; Podophyllotoxin; Prostatic Neoplasms; Testicular Neoplasms; Urogenital Neoplasms | 1985 |
Phase II trial of VP-16-213 in advanced ovarian carcinoma.
Topics: Administration, Oral; Aged; Carcinoma; Cisplatin; Cystadenocarcinoma; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Infusions, Parenteral; Middle Aged; Nausea; Ovarian Neoplasms; Podophyllotoxin; Vomiting | 1985 |
Phase II trial of oral VP 16-213 (etoposide) in patients with advanced head and neck cancer.
Topics: Aged; Drug Evaluation; Etoposide; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Podophyllotoxin | 1985 |
Phase II study of etoposide (VP-16) in the treatment of advanced head and neck cancer.
Topics: Alopecia; Carcinoma, Squamous Cell; Drug Evaluation; Etoposide; Head and Neck Neoplasms; Humans; Leukopenia; Lymphatic Metastasis; Podophyllotoxin | 1985 |
[Antitumor effect of etoposide and its analogs].
Topics: Animals; Cell Division; Dogs; Etoposide; HeLa Cells; Humans; Leukemia L1210; Male; Mice; Podophyllotoxin; Structure-Activity Relationship | 1985 |
The effect of etoposide on human CFU-GM.
Topics: Cell Count; Cell Survival; Etoposide; Granulocytes; Hematopoietic Stem Cells; Humans; In Vitro Techniques; Monocytes; Podophyllotoxin; Protein Binding; Serum Albumin; Serum Albumin, Bovine | 1985 |
Horseradish peroxidase/hydrogen peroxide-catalyzed oxidation of VP16-213. Identification of a new metabolite.
Topics: Acetylation; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Etoposide; Free Radicals; Horseradish Peroxidase; Hydrogen Peroxide; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction; Peroxidases; Podophyllotoxin | 1985 |
The role of metabolic activation by cytochrome P-450 in covalent binding of VP 16-213 to rat liver and HeLa cell microsomal proteins.
Topics: Animals; Ascorbic Acid; Biotransformation; Cytochrome P-450 Enzyme System; Etoposide; HeLa Cells; Humans; In Vitro Techniques; Microsomes; Microsomes, Liver; NADP; Neoplasm Proteins; Nitrogen Oxides; Phenobarbital; Podophyllotoxin; Proadifen; Protein Binding; Pyridines; Rats; Rats, Inbred Strains | 1985 |
[The antitumor activity of intraperitoneally- or orally-administered etoposide in animals and its administration-schedule dependency].
Topics: Adenocarcinoma; Administration, Oral; Animals; Carcinoma, Ehrlich Tumor; Colonic Neoplasms; Drug Administration Schedule; Etoposide; Female; Leukemia, Experimental; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Podophyllotoxin | 1985 |
Timing- and sequence-dependent synergism between etoposide and methotrexate or etoposide, methotrexate and 5-fluorouracil in advanced leukemia L1210.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Etoposide; Female; Fluorouracil; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Podophyllotoxin; Time Factors | 1985 |
Circadian rhythm in tolerance of mice for etoposide.
Topics: Animals; Body Weight; Circadian Rhythm; Disease Models, Animal; Drug Tolerance; Etoposide; Leukocyte Count; Light; Lung Diseases; Male; Mathematics; Mice; Podophyllotoxin | 1985 |
Radioimmunoassay for etoposide and teniposide.
Topics: Animals; Antibody Affinity; Cross Reactions; Dogs; Etoposide; Humans; Liver; Metabolic Clearance Rate; Mice; Podophyllotoxin; Rabbits; Radioimmunoassay; Teniposide | 1985 |
Phase II trial of etoposide, vincristine, and high-dose cisplatin in advanced non-small cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Evaluation; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Vincristine | 1985 |
Remission of brain metastases from small-cell lung cancer after high-dose chemotherapy.
Topics: Brain Neoplasms; Carcinoma, Small Cell; Etoposide; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1984 |
Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.
Topics: Animals; Cattle; DNA, Neoplasm; Etoposide; HeLa Cells; Humans; Kinetics; Phosphorus Radioisotopes; Podophyllotoxin; Teniposide; Thymus Gland; Topoisomerase II Inhibitors | 1984 |
Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.
Topics: Animals; Cattle; Cell Nucleus; Cell Survival; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Leukemia L1210; Mice; Podophyllotoxin; Structure-Activity Relationship; Teniposide; Thymus Gland | 1984 |
Phase II trial of etoposide in previously treated small cell carcinoma of the lung.
Topics: Carcinoma, Small Cell; Drug Evaluation; Etoposide; Female; Humans; Lung Neoplasms; Male; Podophyllotoxin | 1984 |
Use of oral VP16-213 as primary chemotherapeutic agent in treatment of gestational trophoblastic disease.
Topics: Administration, Oral; Chorionic Gonadotropin; Drug Evaluation; Etoposide; Female; Humans; Ovarian Function Tests; Podophyllotoxin; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms | 1984 |
Feasibility of high dose VP 16-213 as single agent or in combination with cyclophosphamide and autologous bone marrow transplantation (ABMT).
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carcinoma, Small Cell; Combined Modality Therapy; Cyclophosphamide; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms, Germ Cell and Embryonal; Podophyllotoxin | 1984 |
Etoposide: a new anti-cancer agent.
Topics: Animals; Drug Evaluation; Etoposide; Female; Humans; Kinetics; Lung Neoplasms; Male; Mitosis; Neoplasms; Podophyllotoxin; Testicular Neoplasms | 1981 |
Remission induction in acute myeloid leukaemia with oral etoposide.
Topics: Administration, Oral; Aged; Etoposide; Female; Humans; Leukemia, Myeloid, Acute; Middle Aged; Podophyllotoxin | 1982 |
Anti-tumour activity of the epipodophyllin derivative VP16-213 (etoposide: NSC-141540) in gestational choriocarcinoma.
Topics: Adult; Bleomycin; Choriocarcinoma; Chorionic Gonadotropin; Drug Therapy, Combination; Etoposide; Female; Humans; Methotrexate; Middle Aged; Podophyllotoxin; Pregnancy; Uterine Neoplasms; Vincristine | 1980 |
Treatment of the blast crisis of chronic myelogenous leukemia with 5-azacitidine and VP-16-213.
Topics: Adult; Aged; Azacitidine; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Podophyllotoxin | 1982 |
Clinical and cell kinetic studies of the effects of the epipodophyllotoxin VP16-213 during therapy of refractory acute nonlymphocytic leukemia.
Topics: Acute Disease; Adolescent; Adult; Azacitidine; Cell Division; Child; Child, Preschool; DNA, Neoplasm; Drug Resistance; Etoposide; Female; Flow Cytometry; Humans; Infant; Kinetics; Leukemia; Male; Mitosis; Podophyllotoxin | 1982 |
Reversal of recurrent laryngeal nerve palsy following VP16-213 combination therapy in a patient with metastatic teratoma of the testis.
Topics: Adult; alpha-Fetoproteins; Bleomycin; Cisplatin; Drug Therapy, Combination; Etoposide; Humans; Laryngeal Nerves; Male; Neoplasm Metastasis; Podophyllotoxin; Recurrent Laryngeal Nerve; Teratoma; Testicular Neoplasms; Vocal Cord Paralysis | 1982 |
Teniposide (VM-26)- and etoposide (VP-16-213)-induced augmentation of methotrexate transport and polyglutamylation in Ehrlich ascites tumor cells in vitro.
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chlorides; Etoposide; Glucose; Kinetics; Methotrexate; Mice; Peptides; Podophyllotoxin; Polyglutamic Acid; Teniposide; Vincristine; Water | 1982 |
Single-agent and combination chemotherapy with etoposide in the acute leukemias of childhood.
Topics: Acute Disease; Azacitidine; Child; Drug Therapy, Combination; Etoposide; Humans; Leukemia; Podophyllotoxin; Prednisone; Vincristine | 1982 |
The treatment of metastatic germ-cell testicular tumours with bleomycin, etoposide and cis-platin (BEP).
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dysgerminoma; Etoposide; Humans; Male; Neoplasms, Germ Cell and Embryonal; Podophyllotoxin; Testicular Neoplasms | 1983 |
Treatment of epidemic Kaposi's sarcoma with etoposide or a combination of doxorubicin, bleomycin, and vinblastine.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Disease Outbreaks; Doxorubicin; Etoposide; Homosexuality; Humans; Infections; Male; Middle Aged; Neoplasm Staging; Podophyllotoxin; Sarcoma, Kaposi; Vinblastine | 1984 |
Cis-dichlorodiammineplatinum (II) and VP 16-213 combination chemotherapy for non-small cell lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cisplatin; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Humans; Injections, Intravenous; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1981 |
VP-16-213 therapy in patients with small-cell carcinoma of the lung after failure on combination chemotherapy.
Topics: Adult; Aged; Carcinoma, Small Cell; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1981 |
Possible enhancement of vincristine neuropathy by VP-16.
Topics: Aged; Carcinoma, Small Cell; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Electrophysiology; Etoposide; Humans; Lung Neoplasms; Male; Middle Aged; Muscles; Nervous System Diseases; Peripheral Nerves; Podophyllotoxin; Vincristine | 1982 |
Phase II study of oral VP-16-213 in hepatocellular carcinoma.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Drug Evaluation; Etoposide; Humans; Liver Neoplasms; Middle Aged; Podophyllotoxin | 1981 |
Epipodophyllotoxin (VP16-213) in small cell carcinoma of the Bronchus resistant to initial combination chemotherapy.
Topics: Bronchial Neoplasms; Carcinoma, Small Cell; Drug Resistance; Drug Therapy, Combination; Etoposide; Humans; Podophyllotoxin | 1982 |
Treatment of small cell lung cancer with a combination of VP16-213 and cyclophosphamide with cisplatin or radiotherapy.
Topics: Adult; Aged; Carcinoma, Small Cell; Cisplatin; Cyclophosphamide; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Time Factors | 1982 |
VP16-213 combined with cis-platinum (CDDP) in the treatment of small cell carcinoma of the lung (SCLC).
Topics: Adult; Aged; Carcinoma, Small Cell; Cisplatin; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1982 |
VP16-213, cisplatinum, and adriamycin salvage therapy of refractory and/or recurrent nonseminomatous germ cell neoplasms.
Topics: Adolescent; Adult; Cisplatin; Doxorubicin; Drug Resistance; Drug Therapy, Combination; Etoposide; Humans; Male; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms, Germ Cell and Embryonal; Podophyllotoxin; Testicular Neoplasms | 1982 |
Cisplatin, adriamycin, and etoposide (CAV) for remission induction of small-cell bronchogenic carcinoma.
Topics: Adult; Aged; Agranulocytosis; Bone Marrow Transplantation; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Cisplatin; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Humans; Leukocyte Count; Male; Middle Aged; Pilot Projects; Podophyllotoxin; Thrombocytopenia | 1982 |
Enhanced radiation reaction following combination chemotherapy for small cell carcinoma of the lung, possibly secondary to VP16-213.
Topics: Aged; Carcinoma, Small Cell; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Radiotherapy; Vincristine | 1982 |
VP16-213 in combined modality treatment of small cell carcinoma of the lung.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; Humans; Lung Neoplasms; Methotrexate; Nausea; Neoplasm Staging; Podophyllotoxin | 1982 |
Small-cell bronchogenic carcinoma--primary and relapse therapy with etoposide (VP-16), methotrexate and CCNU.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Drug Therapy, Combination; Etoposide; Humans; Lomustine; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Podophyllotoxin | 1982 |
Etoposide after ACO treatment for small-cell bronchogenic carcinoma.
Topics: Aged; Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Cisplatin; Cyclophosphamide; Doxorubicin; Etoposide; Humans; Lung Neoplasms; Middle Aged; Podophyllotoxin; Vincristine | 1982 |
Etoposide single-agent chemotherapy for solid tumors.
Topics: Carcinoma, Hepatocellular; Etoposide; Female; Head and Neck Neoplasms; Humans; Liver Neoplasms; Neoplasms; Ovarian Neoplasms; Podophyllotoxin; Sarcoma; Soft Tissue Neoplasms | 1982 |
Etoposide salvage therapy for refractory germ cell tumors: an update.
Topics: Antineoplastic Agents; Drug Therapy, Combination; Etoposide; Humans; Male; Neoplasms, Germ Cell and Embryonal; Podophyllotoxin; Testicular Neoplasms | 1982 |
Etoposide as single agent and in combination chemotherapy of bronchogenic carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Cisplatin; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1982 |
Combination cis-platinum and etoposide in small-cell lung cancer.
Topics: Adult; Aged; Carcinoma, Small Cell; Cisplatin; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1982 |
Combination chemotherapy of small-cell bronchogenic carcinoma with etoposide (VP-16), ifosfamide and vindesine (VPIV), and with adriamycin, cis-platinum and vincristine (APO).
Topics: Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Cisplatin; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Podophyllotoxin; Vinblastine; Vincristine; Vindesine | 1982 |
VP-16 plus cyclophosphamide in the treatment of advanced lung cancer.
Topics: Adult; Aged; Carcinoma, Small Cell; Cyclophosphamide; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Probability | 1983 |
Etoposide in small cell lung cancer resistant to prior chemotherapy.
Topics: Carcinoma, Small Cell; Drug Resistance; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1983 |
High-dose etoposide as single-agent chemotherapy for small cell carcinoma of the lung.
Topics: Adult; Aged; Carcinoma, Small Cell; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1983 |
Etoposide-induced hepatic injury: a potential complication of high-dose therapy.
Topics: Adult; Chemical and Drug Induced Liver Injury; Etoposide; Humans; Liver Diseases; Liver Function Tests; Male; Neoplasms, Germ Cell and Embryonal; Podophyllotoxin | 1983 |
Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents.
Topics: Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Benzoates; Benzoic Acid; Cell Survival; Disulfiram; Ditiocarb; DNA; Etoposide; Leukemia L1210; Mice; NADP; Podophyllotoxin; Thiocarbamates | 1984 |
VP-16 alone and in combination with cisplatin in previously treated patients with small cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Drug Evaluation; Etoposide; Female; Humans; Leukopenia; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Thrombocytopenia; Time Factors | 1984 |
Chemotherapy of refractory germ cell cancer with Etoposide.
Topics: Adolescent; Adult; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Choriocarcinoma; Cisplatin; Dysgerminoma; Etoposide; Humans; Lung Neoplasms; Male; Mesonephroma; Nausea; Neoplasms, Germ Cell and Embryonal; Podophyllotoxin; Retroperitoneal Neoplasms; Testicular Neoplasms | 1983 |
Penetration of VP 16-213 into cerebrospinal fluid after high-dose intravenous administration.
Topics: Adult; Aged; Blood-Brain Barrier; Brain Neoplasms; Carcinoma, Small Cell; Drug Evaluation; Etoposide; Humans; Injections, Intravenous; Lung Neoplasms; Middle Aged; Podophyllotoxin; Tomography, X-Ray Computed | 1984 |
Etoposide (VP 16-213; VePesid).
Topics: Carcinoma, Small Cell; Etoposide; Humans; Lung Neoplasms; Male; Podophyllotoxin; Testicular Neoplasms | 1984 |
Oral etoposide in gestational trophoblastic disease.
Topics: Adolescent; Adult; Alopecia; Chorionic Gonadotropin; Drug Evaluation; Etoposide; Female; Humans; Middle Aged; Nausea; Parity; Podophyllotoxin; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms | 1984 |
[Effects of oral etoposide in small cell carcinoma of the lung].
Topics: Administration, Oral; Adult; Aged; Capsules; Carcinoma, Small Cell; Etoposide; Humans; Leukopenia; Lung Neoplasms; Male; Nausea; Podophyllotoxin; Thrombocytopenia | 1984 |
Etoposide infusions for treatment of metastatic lung cancer.
Topics: Carcinoma, Small Cell; Chromatography, High Pressure Liquid; Etoposide; Follow-Up Studies; Humans; Infusions, Parenteral; Kinetics; Lung Neoplasms; Neoplasm Metastasis; Podophyllotoxin | 1984 |
[Treatment of bronchopulmonary small cell carcinoma with a combination of cyclophosphamide and VP-16].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Combined Modality Therapy; Cyclophosphamide; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1984 |
Inhibition of the DNA catenation activity of type II topoisomerase by VP16-213 and VM26.
Topics: Animals; DNA Topoisomerases, Type I; DNA, Neoplasm; Etoposide; Liver Neoplasms, Experimental; Podophyllotoxin; Rats; Structure-Activity Relationship; Teniposide; Topoisomerase II Inhibitors | 1984 |
High-dose VP-16-213 and autologous bone marrow transplantation for refractory malignancies: a phase I study.
Topics: Adolescent; Adult; Aged; Blood Cell Count; Bone Marrow; Bone Marrow Transplantation; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Evaluation; Drug Resistance; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Podophyllotoxin | 1983 |
High-dose VP-16-213 monotherapy for refractory germinal malignancies: a phase II study.
Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Transplantation; Chemical and Drug Induced Liver Injury; Choriocarcinoma; Combined Modality Therapy; Drug Evaluation; Drug Resistance; Dysgerminoma; Etoposide; Female; Humans; Male; Nausea; Neutropenia; Podophyllotoxin; Pregnancy; Teratoma; Vomiting | 1984 |
Effect of intracarotid etoposide on opening the blood-brain barrier.
Topics: Animals; Blood-Brain Barrier; Brain; Carotid Artery, External; Dose-Response Relationship, Drug; Etoposide; Female; Infusions, Intra-Arterial; Pentetic Acid; Podophyllotoxin; Rats; Rats, Inbred Strains; Technetium; Technetium Tc 99m Pentetate | 1984 |
[Action of alkaloids from podophyllin on the response of pancreatic beta-cells of the rabbit to tolbutamide].
Topics: Animals; Etoposide; Insulin; Insulin Secretion; Islets of Langerhans; Podophyllotoxin; Rabbits; Teniposide; Tolbutamide | 1983 |
Evaluation of intravitreal 5-fluorouracil, vincristine, VP 16, doxorubicin, and thiotepa in primate eyes.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Electroretinography; Etoposide; Fluorouracil; Macaca fascicularis; Podophyllotoxin; Retina; Thiotepa; Vincristine; Vitreous Body | 1984 |
Malignant histiocytosis. Response to VP-16-213 and cytosine arabinoside.
Topics: Aged; Cytarabine; Etoposide; Female; Humans; Lymph Nodes; Lymphatic Diseases; Podophyllotoxin | 1984 |
Etoposide-induced blood-brain barrier disruption. Effect of drug compared with that of solvents.
Topics: Animals; Benzyl Alcohol; Benzyl Alcohols; Blood-Brain Barrier; Brain; Capillary Permeability; Citrates; Citric Acid; Etoposide; Female; Podophyllotoxin; Polyethylene Glycols; Polysorbates; Radionuclide Imaging; Rats; Rats, Inbred Strains; Solvents | 1984 |
[A phase II clinical trial of oral VP 16-213 in advanced non-Hodgkin's lymphoma].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Evaluation; Drug Resistance; Etoposide; Humans; Lymphoma; Podophyllotoxin; Vincristine | 1984 |
Characterization of VP-16-induced DNA damage in isolated nuclei from L1210 cells.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; DNA; Etoposide; Hydrogen-Ion Concentration; Leukemia L1210; Magnesium; Mice; Nucleotides; Podophyllotoxin; Temperature | 1984 |
Phase II trial of etoposide in advanced prostate cancer.
Topics: Aged; Bone Marrow Diseases; Drug Evaluation; Etoposide; Humans; Infusions, Parenteral; Male; Middle Aged; Podophyllotoxin; Prostatic Neoplasms | 1984 |
Penetration of VP-16 (etoposide) into human intracerebral and extracerebral tumors.
Topics: Brain Neoplasms; Etoposide; Glioma; Half-Life; Humans; Kinetics; Necrosis; Neoplasms; Podophyllotoxin | 1984 |
Synergistic antitumor activity of vincristine and VP-16-213.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Etoposide; Leukemia, Experimental; Male; Mice; Podophyllotoxin; Vincristine | 1984 |
[Effect of etoposide for pulmonary metastases from urogenital tract cancer].
Topics: Adenocarcinoma; Administration, Oral; Aged; Carcinoma, Transitional Cell; Etoposide; Humans; Infusions, Parenteral; Kidney Neoplasms; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Prostatic Neoplasms; Urinary Bladder Neoplasms; Urologic Neoplasms | 1984 |
Irreversible binding of etoposide (VP-16-213) to deoxyribonucleic acid and proteins.
Topics: Animals; Chemical Phenomena; Chemistry; DNA; Etoposide; Kinetics; Male; Mice; Microsomes, Liver; Podophyllotoxin; Protein Binding; Proteins | 1984 |
High-dose etoposide for refractory malignancies: a phase I study.
Topics: Adult; Aged; Bone Marrow; Diarrhea; Drug Evaluation; Erythema; Etoposide; Female; Humans; Male; Middle Aged; Mouth Diseases; Neoplasm Metastasis; Neoplasms; Paresthesia; Podophyllotoxin; Reflex | 1984 |
Phase II trial of etoposide in the management of advanced or recurrent non-squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Drug Evaluation; Etoposide; Female; Humans; Middle Aged; Podophyllotoxin; Uterine Cervical Neoplasms | 1984 |
High-performance liquid chromatographic determination of etoposide in plasma using electrochemical detection.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Etoposide; Humans; Podophyllotoxin; Solvents | 1984 |
Etoposide by oral route in the treatment of unresectable non-small cell lung cancer.
Topics: Administration, Oral; Aged; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1984 |
Pharmacokinetics of etoposide (VP16) in children and adolescents with refractory solid tumors.
Topics: Adolescent; Adult; Child; Child, Preschool; Cisplatin; Etoposide; Female; Humans; Kinetics; Leukemia; Male; Metabolic Clearance Rate; Neoplasms; Podophyllotoxin | 1984 |
Establishment of an etoposide-resistant human epithelial tumour cell line in vitro: characterization of patterns of cross-resistance and drug sensitivities.
Topics: Carcinoma, Squamous Cell; Cell Line; Cisplatin; DNA, Neoplasm; Drug Resistance; Etoposide; Fluorouracil; Humans; Podophyllotoxin; Teniposide; Tongue Neoplasms; Vincristine; X-Rays | 1984 |
Effects of the epipodophyllotoxin VP-16-213 on cell cycle traverse, DNA synthesis, and DNA strand size in cultures of human leukemic lymphoblasts.
Topics: Cell Cycle; Cell Line; DNA Replication; DNA, Neoplasm; Etoposide; Humans; Kinetics; Leukemia, Lymphoid; Podophyllotoxin | 1983 |
[VP 16-213 in the treatment of acute leukemia in childhood].
Topics: Acute Disease; Adolescent; Antineoplastic Agents; Child; Child, Preschool; Cytarabine; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Humans; Leukemia; Leukemia, Lymphoid; Male; Podophyllotoxin | 1983 |
Comparative cytotoxic and cytokinetic effects of the epipodophyllotoxins 4'-demethylepipodophyllotoxin-9-(4,6-O-2-ethylidene-beta-D-glucopyranoside) and 4'-demethylepipodophyllotoxin-9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) and their metabolites on
Topics: Cell Cycle; Cell Line; Cell Survival; Clone Cells; Dose-Response Relationship, Drug; Etoposide; Humans; Kinetics; Leukemia, Lymphoid; Podophyllotoxin; Structure-Activity Relationship; Teniposide | 1983 |
Tumor lysis syndrome following VP-16-213 in chronic myeloid leukemia in blast crisis.
Topics: Adult; Chromosomes, Human, 21-22 and Y; Etoposide; Fever; Heart Arrest; Humans; Hypocalcemia; Leukemia, Myeloid; Male; Phosphates; Podophyllotoxin; Syncope | 1984 |
4'-Demethylepipodophyllotoxin-beta-D-glucoside: a new podophyllotoxin derivative with VM-26-like and VP-16-213-like activities.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Etoposide; Female; Ovary; Podophyllotoxin; Structure-Activity Relationship; Teniposide | 1984 |
Automated liquid chromatographic analysis of the anti-tumorigenic drugs etoposide (VP 16-213) and teniposide (VM 26).
Topics: Autoanalysis; Chromatography, Liquid; Etoposide; Humans; Hydrolysis; Podophyllotoxin; Teniposide | 1983 |
[Phase I study of an oral administration of VP 16-213].
Topics: Administration, Oral; Adult; Aged; Capsules; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Lung Neoplasms; Lymphoma; Male; Middle Aged; Podophyllotoxin | 1983 |
Stevens-Johnson syndrome associated with etoposide therapy.
Topics: Etoposide; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Stevens-Johnson Syndrome | 1983 |
Free radical metabolism of VP-16 and inhibition of anthracycline-induced lipid peroxidation.
Topics: Animals; Daunorubicin; Etoposide; Free Radicals; Horseradish Peroxidase; Hydrogen Peroxide; Lipid Peroxides; Male; Mice; Microsomes, Liver; Oxygen; Podophyllotoxin | 1983 |
Skin ulceration potential without therapeutic anticancer activity for epipodophyllotoxin commercial diluents.
Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Etoposide; Humans; Leukemia P388; Leukemia, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Podophyllotoxin; Skin Ulcer; Solvents; Teniposide; Tumor Stem Cell Assay | 1983 |
cis-platinum and etoposide combination chemotherapy of advanced non-oat cell bronchogenic carcinoma.
Topics: Adult; Aged; Carcinoma, Bronchogenic; Cisplatin; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1983 |
Pharmacokinetics of high-dose etoposide (VP-16-213) administered to cancer patients.
Topics: Etoposide; Half-Life; Humans; Kinetics; Neoplasms; Podophyllotoxin | 1984 |
Phase II study of VP 16-213 (etoposide) in metastatic transitional cell urothelial cancer.
Topics: Adult; Aged; Carcinoma, Transitional Cell; Drug Evaluation; Etoposide; Humans; Infusions, Parenteral; Middle Aged; Podophyllotoxin; Urinary Bladder Neoplasms | 1984 |
Analysis of the inhibitory effects of VP-16-213 (etoposide) and podophyllotoxin on thymidine transport and metabolism in Ehrlich ascites tumor cells in vitro.
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Chromatography, High Pressure Liquid; DNA Replication; Etoposide; Kinetics; Male; Mice; Podophyllotoxin; Thymidine; Tritium | 1984 |
High-performance liquid chromatographic analysis of the semisynthetic epipodophyllotoxins teniposide and etoposide using electrochemical detection.
Topics: Body Fluids; Chromatography, High Pressure Liquid; Electrochemistry; Etoposide; Humans; Kinetics; Podophyllotoxin; Teniposide | 1984 |
Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship.
Topics: Adenocarcinoma; Cell Line; Cell Survival; DNA; DNA Repair; Etoposide; Humans; Kinetics; Lung Neoplasms; Podophyllotoxin; Structure-Activity Relationship; Teniposide | 1984 |
[Phase II study of etoposide in malignant lymphoma].
Topics: Adult; Aged; Drug Evaluation; Etoposide; Female; Humans; Lymphoma; Male; Middle Aged; Podophyllotoxin | 1984 |
Etoposide (VP-16-213) in malignant brain tumors: a phase II study.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Drug Evaluation; Etoposide; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Podophyllotoxin; Teniposide; Time Factors; Tomography, X-Ray Computed | 1984 |
[Etoposide effect on cell cycle kinetics of a human lung cancer cell line].
Topics: Cell Count; Cell Cycle; Cell Division; Cell Line; Cell Survival; DNA, Neoplasm; Etoposide; Flow Cytometry; Humans; Lung Neoplasms; Podophyllotoxin | 1984 |
Potentiation of etoposide-induced DNA damage by calcium antagonists in L1210 cells in vitro.
Topics: Animals; Cell Division; Cell Nucleus; Cell Survival; DNA Replication; DNA, Neoplasm; Drug Synergism; Etoposide; Gallopamil; Kinetics; Leukemia L1210; Mice; Podophyllotoxin; Verapamil | 1984 |
Mitomycin-C, VP16-213 combination as third line chemotherapy in advanced breast cancer.
Topics: Adult; Breast Neoplasms; Drug Therapy, Combination; Etoposide; Female; Humans; Middle Aged; Mitomycin; Mitomycins; Podophyllotoxin | 1982 |
New anticancer drug class.
Topics: Child; Etoposide; Humans; Legislation, Drug; Neoplasms; Podophyllotoxin; Teniposide; United States | 1983 |
Genetic, biochemical, and cross-resistance studies with mutants of Chinese hamster ovary cells resistant to the anticancer drugs, VM-26 and VP16-213.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line; Cricetinae; Cricetulus; Daunorubicin; Drug Resistance; Etoposide; Female; Mutation; Ovary; Phenotype; Podophyllotoxin; Teniposide | 1983 |
DNA damage as a basis for 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucopyranoside) (etoposide) cytotoxicity.
Topics: Animals; Chemical Phenomena; Chemistry; Colony-Forming Units Assay; DNA; DNA, Single-Stranded; Dose-Response Relationship, Drug; Etoposide; Leukemia L1210; Mice; Podophyllotoxin | 1983 |
Phase II study of etoposide in the treatment of esophageal carcinoma.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Drug Evaluation; Esophageal Neoplasms; Etoposide; Humans; Middle Aged; Podophyllotoxin | 1983 |
Phase II trial of etoposide in adenocarcinomas of the upper gastrointestinal tract.
Topics: Adenocarcinoma; Adult; Aged; Drug Evaluation; Etoposide; Female; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Podophyllotoxin | 1983 |
VP16-213 and cyclophosphamide in advanced breast cancer. A phase II study.
Topics: Adult; Aged; Breast Neoplasms; Cyclophosphamide; Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Etoposide; Female; Humans; Middle Aged; Neoplasm Metastasis; Podophyllotoxin; Prognosis | 1983 |
Flow-cytometric analysis of DNA distribution after VP16-213 treatment of Lewis lung carcinoma.
Topics: Animals; Cell Cycle; Cell Line; DNA, Neoplasm; Etoposide; Flow Cytometry; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Podophyllotoxin | 1983 |
In vitro cytotoxicity of VP 16 on primary tumor and metastasis of Lewis lung carcinoma.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Etoposide; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasms, Experimental; Podophyllotoxin; Thymidine | 1982 |
In vivo resistance towards anthracyclines, etoposide, and cis-diamminedichloroplatinum(II).
Topics: Animals; Carcinoma, Ehrlich Tumor; Cisplatin; Daunorubicin; Doxorubicin; Drug Administration Schedule; Drug Resistance; Etoposide; Kinetics; Mice; Podophyllotoxin; Structure-Activity Relationship | 1982 |
A review of etoposide in patients with non-small-cell lung cancer (NSCLC).
Topics: Cisplatin; Drug Therapy, Combination; Etoposide; Humans; Lung Neoplasms; Podophyllotoxin | 1982 |
Etoposide alone and in combination with cyclophosphamide, adriamycin and cis-platinum in patients with Mo and Mi non-small-cell lung cancer.
Topics: Adenocarcinoma; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Podophyllotoxin | 1982 |
Etoposide and cis-platinum in non-small-cell bronchogenic carcinoma.
Topics: Carcinoma, Bronchogenic; Cisplatin; Drug Therapy, Combination; Etoposide; Humans; Lung Neoplasms; Podophyllotoxin | 1982 |
Treatment of inoperable non-small-cell bronchogenic carcinoma with etoposide and cis-platinum.
Topics: Carcinoma, Bronchogenic; Cisplatin; Drug Therapy, Combination; Etoposide; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1982 |
Etoposide as single agent and in combination with cis-platinum for malignant lymphomas.
Topics: Adult; Aged; Blood; Cisplatin; Drug Therapy, Combination; Etoposide; Humans; Lymphoma; Middle Aged; Podophyllotoxin | 1982 |
Cis-dichlorodiammineplatinum (II) (cis-platinum) and etoposide for patients with refractory lymphomas.
Topics: Adult; Cisplatin; Drug Therapy, Combination; Etoposide; Female; Humans; Lymphoma; Male; Middle Aged; Podophyllotoxin | 1982 |
Combination chemotherapy with cisplatin and etoposide in bronchogenic squamous cell carcinoma and adenocarcinoma. A study by the EORTC lung cancer working party (Belgium).
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Cisplatin; Drug Evaluation; Drug Therapy, Combination; Etoposide; Humans; Lung Neoplasms; Middle Aged; Podophyllotoxin | 1982 |
In vitro and in vivo metabolism of VP 16-213 in the rat.
Topics: Animals; Chromatography, High Pressure Liquid; Etoposide; In Vitro Techniques; Liver; Male; Microsomes, Liver; Podophyllotoxin; Rabbits; Rats; Rats, Inbred Strains; Subcellular Fractions | 1982 |
Adriamycin and VP16-213 combination treatment for breast cancer previously treated by the CMF regimen.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Resistance; Drug Therapy, Combination; Etoposide; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Neoplasm Metastasis; Podophyllotoxin | 1982 |
Pilot studies of various combinations of dibromodulcitol, VP-16, and AMSA.
Topics: Aged; Aminoacridines; Amsacrine; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Humans; Male; Middle Aged; Mitolactol; Neoplasms; Pilot Projects; Podophyllotoxin | 1982 |
[Prospects of new chemotherapies].
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cisplatin; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Humans; Male; Neoplasms; Podophyllotoxin; Vinblastine; Vindesine | 1982 |
VP-16 and adriamycin in patients with advanced breast cancer.
Topics: Adenocarcinoma; Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dexamethasone; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Fluorouracil; Humans; Leukopenia; Male; Methotrexate; Middle Aged; Podophyllotoxin; Prednisone; Thrombocytopenia; Vincristine; Vomiting | 1982 |
High-dose VP 16-213 (NSC 141540) for the treatment of patients with previously treated acute leukemia.
Topics: Adult; Antineoplastic Agents; Child; Drug Evaluation; Esophagitis; Etoposide; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Nausea; Pilot Projects; Podophyllotoxin; Vomiting | 1980 |
Cytokinetic changes in the peripheral blood of leukemic patients during cytostatic therapy. V. Effect of VP 16 213 studied with flow cytofluorometry and cytoautoradiography.
Topics: Autoradiography; Bone Marrow Cells; Etoposide; Histocytochemistry; Humans; Leukemia, Lymphoid; Leukocyte Count; Podophyllotoxin | 1980 |
Model studies of etoposide resistance.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Etoposide; Naphthacenes; Podophyllotoxin | 1982 |
Glycosylated podophyllotoxin congeners: loss of microtubule inhibition and permission of invasion in vitro.
Topics: Animals; Cell Division; Chick Embryo; Etoposide; Fibrosarcoma; Mice; Microtubules; Myocardium; Organ Culture Techniques; Podophyllotoxin; Teniposide | 1982 |
Phase II trial of VP-16-213 in non-small-cell lung cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Bone Marrow; Carcinoma, Squamous Cell; Digestive System; Drug Evaluation; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1982 |
Etoposide (VP16-213) and teniposide (VM26) comparative in vitro activities in human tumors.
Topics: Antineoplastic Agents; Cells, Cultured; Etoposide; Humans; Neoplasms; Neoplasms, Experimental; Podophyllotoxin; Teniposide | 1982 |
A radioimmunoassay for VP16-213 in plasma.
Topics: Animals; Chemical Phenomena; Chemistry; Cross Reactions; Etoposide; Histamine; Humans; Podophyllotoxin; Radioimmunoassay; Sheep | 1982 |
Interaction of VP16-213 with the DNA repair antagonist chloroquine.
Topics: Animals; Chloroquine; DNA Repair; Drug Interactions; Etoposide; Female; Lymphoma; Mice; Mice, Inbred CBA; Neoplasms, Experimental; Podophyllotoxin; Vincristine | 1982 |
Pharmacokinetics of VP16-213 in Lewis lung carcinoma bearing mice.
Topics: Animals; Etoposide; Kinetics; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Podophyllotoxin; Tissue Distribution | 1982 |
Pharmacokinetics of VP16-213 given by different administration methods.
Topics: Administration, Oral; Adult; Aging; Biological Availability; Child; Etoposide; Humans; Injections, Intravenous; Kinetics; Podophyllotoxin | 1982 |
Pharmacokinetics of Teniposide (VM26) and etoposide (VP16-213) in children with cancer.
Topics: Biotransformation; Child; Chromatography, High Pressure Liquid; Etoposide; Humans; Kinetics; Leukemia; Models, Biological; Neoplasms; Podophyllotoxin; Teniposide | 1982 |
Combination chemotherapy of the epipodophyllotoxin derivatives, teniposide and etoposide. A pharmacodynamic rationale?
Topics: Adult; Aged; Ascitic Fluid; Drug Interactions; Drug Therapy, Combination; Etoposide; Female; Humans; Kinetics; Male; Middle Aged; Models, Biological; Podophyllotoxin; Protein Binding; Teniposide | 1982 |
A phase I trial of continuous infusion VP16-213 (etoposide).
Topics: Adult; Aged; Drug Evaluation; Etoposide; Female; Heart Diseases; Hematologic Diseases; Humans; Infusions, Parenteral; Male; Middle Aged; Neoplasms; Podophyllotoxin | 1982 |
Etoposide as a single agent in relapsed advanced lymphomas. A phase II study.
Topics: Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Etoposide; Humans; Lymphoma; Middle Aged; Neoplasm Recurrence, Local; Podophyllotoxin | 1982 |
Phase II trial of VP16-213 in non-small cell lung cancer (NSCLC).
Topics: Adult; Aged; Drug Evaluation; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1982 |
VP16-213 and cyclophosphamide in non oat cell bronchogenic carcinoma.
Topics: Carcinoma, Bronchogenic; Cyclophosphamide; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Podophyllotoxin | 1982 |
The role of VP16-213 (etoposide; NSC-141540) in gestational choriocarcinoma.
Topics: Choriocarcinoma; Drug Resistance; Etoposide; Female; Humans; Podophyllotoxin; Pregnancy; Risk; Uterine Neoplasms | 1982 |
Phase II study of VP16-213 (etoposide) in refractory metastatic breast carcinoma.
Topics: Adult; Aged; Breast Neoplasms; Drug Evaluation; Drug Resistance; Etoposide; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Podophyllotoxin | 1982 |
IMVP-16: an effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Cyclophosphamide; Drug Therapy, Combination; Etoposide; Humans; Ifosfamide; Inflammation; Lymphoma; Methotrexate; Mucous Membrane; Neutropenia; Podophyllotoxin; Recurrence | 1982 |
Phase II trial of etoposide in the management of advanced or recurrent endometrial carcinoma: a Gynecologic Oncology Group Study.
Topics: Adult; Aged; Drug Evaluation; Etoposide; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Podophyllotoxin; Uterine Neoplasms | 1982 |
Proceedings of the German Cancer Society (Clinical Oncology Section) and Bristol-Myers GmbH Symposium on Etoposide (VP-16). Current status and new developments. Frankfurt, 21-22 May 1981.
Topics: Etoposide; Humans; Neoplasms; Podophyllotoxin | 1982 |
Etoposide and ifosfamide in combination for inoperable carcinoma of the bronchus.
Topics: Bronchial Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Etoposide; Humans; Ifosfamide; Podophyllotoxin | 1982 |
Etoposide--chemistry, preclinical and clinical pharmacology.
Topics: Animals; Chemical Phenomena; Chemistry; Drug Therapy, Combination; Etoposide; Humans; Kinetics; Neoplasms, Experimental; Podophyllotoxin | 1982 |
Etoposide in the treatment of acute leukemia in adults.
Topics: Acute Disease; Adult; Drug Administration Schedule; Drug Therapy, Combination; Etoposide; Humans; Leukemia; Podophyllotoxin | 1982 |
Etoposide in the treatment of refractory breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Drug Therapy, Combination; Etoposide; Female; Humans; Podophyllotoxin | 1982 |
Etoposide for therapy-resistant testicular tumors.
Topics: Adult; Antineoplastic Agents; Drug Resistance; Drug Therapy, Combination; Etoposide; Humans; Male; Middle Aged; Podophyllotoxin; Testicular Neoplasms | 1982 |
Etoposide and etoposide-ifosfamide therapy for refractory testicular tumors.
Topics: Cyclophosphamide; Drug Therapy, Combination; Etoposide; Humans; Ifosfamide; Male; Podophyllotoxin; Testicular Neoplasms | 1982 |
Synthesis, 470-MHz 1H NMR spectra, and activity of delactonized derivatives of the anticancer drug etoposide.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Etoposide; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Podophyllotoxin | 1982 |
Etoposide--an effective single drug for treating bronchogenic carcinoma.
Topics: Bone Marrow; Carcinoma, Bronchogenic; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin | 1982 |
[Etoposide: VP-16].
Topics: Etoposide; Humans; Lung Neoplasms; Lymphoma; Neoplasms; Podophyllotoxin | 1982 |
Preliminary study of the combination, dianhydrogalactitol, cis-diaminedichloroplatinum (II), and VP-16-213 in patients with advanced cancer.
Topics: Brain Neoplasms; Carcinoma, Squamous Cell; Cisplatin; Dianhydrogalactitol; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Pilot Projects; Podophyllotoxin; Sugar Alcohols | 1981 |
[Chemotherapy of non-small-cell bronchial cancer with a combination of Cis-diamminedichloroplatinum (II) and VP 16-213].
Topics: Adenocarcinoma; Body Weight; Carcinoma; Carcinoma, Squamous Cell; Cisplatin; Drug Therapy, Combination; Etoposide; Humans; Leukocyte Count; Lung Neoplasms; Podophyllotoxin; Vomiting | 1981 |
High-performance liquid chromatography determination of 4'-demethyl-epipodophyllotoxin-9-(4,6-O-ethylidene beta-D-glucopyranoside) (VP 16-213) in human plasma.
Topics: Adult; Chromatography, High Pressure Liquid; Drug Stability; Etoposide; Female; Humans; Kinetics; Podophyllotoxin; Spectrophotometry, Ultraviolet | 1981 |
VP16-213 as a single agent in advanced testicular tumors.
Topics: Drug Evaluation; Dysgerminoma; Etoposide; Humans; Leukopenia; Male; Podophyllotoxin; Teratoma; Testicular Neoplasms; Thrombocytopenia | 1980 |
A phase II study of oral VP-16-213 in non-seminomatous testicular cancer.
Topics: Adult; Drug Evaluation; Etoposide; Humans; Leukopenia; Male; Middle Aged; Podophyllotoxin; Teratoma; Testicular Neoplasms; Time Factors | 1981 |
Analysis of the anticancer drugs etoposide (VP 16-213) and teniposide (VM 26) by high-performance liquid chromatography with fluorescence detection.
Topics: Chromatography, High Pressure Liquid; Etoposide; Humans; Podophyllotoxin; Reference Values; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Teniposide; Time Factors | 1981 |
Response of L1210 leukemia to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea plus 4'-demethylepipodophyllotoxin-9-(4,6-O-2-thenylidene-beta-D-glucopyranoside).
Topics: Animals; Carmustine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Etoposide; Female; Leukemia L1210; Mice; Mice, Inbred Strains; Podophyllotoxin; Prognosis | 1981 |
Oral VP-16-213 in advanced bronchogenic carcinoma and toxic effects when combined with methotrexate.
Topics: Bone Marrow Diseases; Doxorubicin; Drug Therapy, Combination; Etoposide; Humans; Lung Neoplasms; Methotrexate; Podophyllotoxin; Vincristine | 1981 |
Oral VP-16-213 in advanced bronchogenic carcinoma.
Topics: Bone Marrow Diseases; Carcinoma, Bronchogenic; Drug Combinations; Etoposide; Humans; Lung Neoplasms; Podophyllotoxin; Vincristine | 1981 |
VP-16-213. A phase II trial using a weekly schedule.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Etoposide; Humans; Neoplasms; Podophyllotoxin | 1981 |
Partial cross-resistance of cultured murine leukemia vincristine-resistant P388 cells to 4'-demethylepipodophyllotoxin ethylidene-beta-D-glucoside.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Etoposide; Leukemia, Experimental; Mice; Podophyllotoxin; Time Factors; Vincristine | 1980 |
Effects of monocytopenia and anticoagulation in experimental Streptococcus sanguis endocarditis.
Topics: Animals; Endocarditis, Bacterial; Endocardium; Etoposide; Granulocytes; Leukocyte Count; Male; Microscopy, Electron; Monocytes; Podophyllotoxin; Rabbits; Streptococcal Infections; Streptococcus sanguis; Warfarin | 1980 |
Successful treatment of lymphohistiocytic reticulosis with phagocytosis with epipodophyllotoxin VP 16-213.
Topics: Blood Cell Count; Etoposide; Female; Humans; Hyperlipidemias; Immunoglobulins; Infant; Lymphatic Diseases; Lymphocyte Activation; Male; Phagocytosis; Podophyllotoxin | 1980 |
Analysis of the anticancer drugs VP 16-213 and VM 26 and their metabolites by high-performance liquid chromatography.
Topics: Adult; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Etoposide; Humans; Isomerism; Kinetics; Male; Podophyllotoxin; Spectrometry, Fluorescence; Teniposide | 1980 |
The effect of VP 16-213 on NBT reduction in the normal polymorphonuclear neutrophil.
Topics: Adult; Etoposide; Humans; In Vitro Techniques; Neutrophils; Nitroblue Tetrazolium; Oxidation-Reduction; Podophyllotoxin; Tetrazolium Salts | 1980 |
Analysis of 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucopyranoside) by high-pressure liquid chromatography.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Etoposide; Humans; Podophyllotoxin | 1980 |
Activity of NK 611, a new epipodophyllotoxin derivative, against colony forming units from freshly explanted human tumours in vitro.
Topics: Antineoplastic Agents; Cell Survival; Dose-Response Relationship, Drug; Etoposide; Humans; Neoplastic Stem Cells; Podophyllotoxin; Tumor Stem Cell Assay | 1995 |
Expression of adhesion molecules on CD34+ cells: CD34+ L-selectin+ cells predict a rapid platelet recovery after peripheral blood stem cell transplantation.
Topics: Adult; Antigens, CD; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Bone Marrow; Bone Marrow Cells; Carboplatin; Carmustine; Cell Adhesion Molecules; Cell Movement; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Epirubicin; Etoposide; Female; Fluorouracil; Gene Expression; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Ifosfamide; L-Selectin; Leukocyte Count; Male; Melphalan; Middle Aged; Neoplasms; Neutrophils; Platelet Count; Podophyllotoxin; Receptors, Very Late Antigen; Thiotepa | 1995 |
Time-course of the recovery of cellular immune function after high-dose chemotherapy and peripheral blood progenitor cell transplantation for high-grade non-Hodgkin's lymphoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Diseases; Busulfan; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Leukapheresis; Lymphocyte Count; Lymphocyte Subsets; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Male; Melphalan; Mesna; Middle Aged; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors; Treatment Outcome; Vincristine | 1995 |
Formation of apoptotic bodies is associated with internucleosomal DNA fragmentation during drug-induced apoptosis.
Topics: Apoptosis; Aurintricarboxylic Acid; Deoxyribonuclease I; DNA; Etoposide; G1 Phase; Humans; Nucleosomes; Podophyllotoxin; T-Lymphocytes; Tumor Cells, Cultured | 1995 |
Pregnancy after autologous bone marrow transplantation for malignant lymphomas.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Infant, Newborn; Lymphoma, Large B-Cell, Diffuse; Mechlorethamine; Melphalan; Podophyllotoxin; Prednisone; Pregnancy; Pregnancy Outcome; Procarbazine; Remission Induction; Salvage Therapy; Vincristine | 1994 |
[Synthesis and antitumor activity of 4-O-(halogenated) acyl-4'-demethylepipodophyllotoxin analogues].
Topics: Animals; Etoposide; Humans; KB Cells; Leukemia L1210; Mice; Podophyllotoxin; Tumor Cells, Cultured | 1993 |
[Synthesis and antitumor activity of 4-S-(5-amido-1,3,4-thiodiazol-2-yl)4-deoxy-4'-demethylepipodophyllotoxi n analogues].
Topics: Animals; Etoposide; Humans; KB Cells; Leukemia L1210; Podophyllotoxin; Tumor Cells, Cultured | 1993 |
Epipodophyllotoxins and secondary leukaemia.
Topics: Etoposide; Humans; Leukemia, Myeloid, Acute; Neoplasms, Second Primary; Podophyllotoxin | 1993 |
Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia.
Topics: Child, Preschool; Chromosomes, Human, Pair 11; DNA-Cytosine Methylases; DNA, Neoplasm; Etoposide; Humans; Leukemia, Monocytic, Acute; Male; Neoplasms, Second Primary; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Translocation, Genetic | 1993 |
Cytotoxic properties of a new synthetic demethylpodophyllotoxin derivative, BN 58705, against human tumor cell lines.
Topics: Animals; Antineoplastic Agents; DNA Damage; DNA, Neoplasm; Etoposide; Female; Humans; Lethal Dose 50; Mice; Mitosis; Podophyllotoxin; Tumor Cells, Cultured; Vincristine | 1993 |
[In vitro comparison of podophyllotoxin analogues; etoposide, teniposide and NK 611 using human lung cancer cell lines].
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cell Division; Drug Resistance; Drug Screening Assays, Antitumor; Etoposide; Humans; Lung Neoplasms; Podophyllotoxin; Teniposide; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1993 |
Antitumor agents. 125. New 4 beta-benzoylamino derivatives of 4'-O-demethyl-4-desoxypodophyllotoxin and 4 beta-benzoyl derivatives of 4'-O-demethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Topics: Antineoplastic Agents; DNA; DNA Damage; Etoposide; Humans; Magnetic Resonance Spectroscopy; Podophyllotoxin; Proteins; Spectrophotometry, Infrared; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1993 |
Antitumor agents. 126. Novel 4 beta-substituted anilino derivatives of 3',4'-O,O-didemethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
Topics: Antineoplastic Agents; Catalysis; DNA; Etoposide; Humans; Hydrogenation; KB Cells; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Podophyllotoxin; Topoisomerase II Inhibitors | 1993 |
Antitumor agents. 3. Synthesis and biological activity of 4 beta-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents.
Topics: Animals; Antineoplastic Agents; Etoposide; Humans; Leukemia L1210; Leukemia P388; Lung Neoplasms; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tubulin Modulators; Tumor Cells, Cultured | 1993 |
Report of the Cancer Therapy Evaluation Program monitoring plan for secondary acute myeloid leukemia following treatment with epipodophyllotoxins.
Topics: Acute Disease; Adult; Child; Clinical Trials as Topic; Etoposide; Humans; Incidence; Leukemia, Myeloid; Myelodysplastic Syndromes; Neoplasms, Second Primary; Podophyllotoxin | 1993 |
Antitumor activity of a new low immunosuppressive derivative of podophyllotoxin (GP-11) and its mechanisms.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Division; Cyclic N-Oxides; Etoposide; Female; Humans; Immunosuppressive Agents; In Vitro Techniques; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Podophyllin; Podophyllotoxin; Spin Labels; Tumor Cells, Cultured | 1993 |
Activities of novel nonglycosidic epipodophyllotoxins in etoposide-sensitive and -resistant variants of human KB cells, P-388 cells, and in vivo multidrug-resistant murine leukemia cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; DNA Damage; Drug Resistance, Multiple; Etoposide; Female; Humans; KB Cells; Leukemia P388; Leukemia, Experimental; Mice; Podophyllotoxin; Topoisomerase II Inhibitors | 1996 |
Mechanisms of resistance of human small cell lung cancer lines selected in VP-16 and cisplatin.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cadmium; Cadmium Chloride; Carcinoma, Small Cell; Cell Line; Chlorides; Cisplatin; Cross Reactions; DNA; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Humans; Lung Neoplasms; Metallothionein; Platinum Compounds; Podophyllotoxin; Teniposide; Tumor Cells, Cultured; Vinca Alkaloids | 1996 |
Topoisomerase II activities in AML blasts and their correlation with cellular sensitivity to anthracyclines and epipodophyllotoxines.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Daunorubicin; DNA Topoisomerases, Type II; Etoposide; Humans; Hydrogen-Ion Concentration; Idarubicin; Leukemia, Myeloid, Acute; Podophyllotoxin; Precipitin Tests; Topoisomerase II Inhibitors | 1996 |
Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors.
Topics: Antineoplastic Agents; Cell Division; DNA; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Etoposide; Humans; KB Cells; Molecular Structure; Phenazines; Podophyllotoxin; Topoisomerase II Inhibitors | 1996 |
Successful mobilisation of blood stem cells following previous autologous bone marrow transplantation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Blood Cells; Bone Marrow; Bone Marrow Transplantation; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Doxorubicin; Epirubicin; Etoposide; Hematopoietic Stem Cells; Humans; Ifosfamide; Leukapheresis; Lymphoma, Follicular; Male; Melphalan; Methotrexate; Podophyllotoxin; Prednisolone; Prednisone; Transplantation Conditioning; Transplantation, Autologous; Vincristine | 1996 |
Endo-exonuclease of human leukaemic cells: evidence for a role in apoptosis.
Topics: Apoptosis; Cell Nucleus; Cytosol; DNA Fragmentation; Endonucleases; Endoplasmic Reticulum; Etoposide; Exonucleases; Humans; Kinetics; Leukemia; Molecular Weight; Podophyllotoxin; Tumor Cells, Cultured | 1996 |
Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL331, a new homolog of etoposide.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; DNA Fragmentation; DNA, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; Lethal Dose 50; Podophyllotoxin; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1996 |
Comparative induction of micronuclei in repair-deficient and -proficient Chinese hamster cell lines following clastogen or aneugen exposures.
Topics: Aneuploidy; Animals; Cell Division; Cell Line; Chromosomes; Cricetinae; Cricetulus; DNA Repair; Etoposide; Kinetochores; Micronucleus Tests; Mutagens; Podophyllotoxin; Radiation Tolerance; X-Rays | 1997 |
Synthesis and biological evaluation of flavanones and flavones related to podophyllotoxin.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Cell Division; Doxorubicin; Etoposide; Flavanones; Flavonoids; Humans; Keratolytic Agents; Podophyllotoxin; Tumor Cells, Cultured | 1998 |
Assay for etoposide in human serum using solid-phase extraction and high-performance liquid chromatography with fluorescence detection.
Topics: Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Etoposide; Humans; Indicators and Reagents; Podophyllotoxin; Reference Standards; Spectrometry, Fluorescence | 1998 |
Discovery of podophyllotoxins.
Topics: Animals; Antineoplastic Agents, Phytogenic; Enzyme Inhibitors; Etoposide; History, 19th Century; History, 20th Century; Humans; Podophyllotoxin; Teniposide; Topoisomerase II Inhibitors | 1998 |
Effects of spin labeled derivatives of podophyllotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Division; DNA, Neoplasm; Etoposide; Humans; Leukemia, Lymphoid; Mitotic Index; Neoplasm Proteins; Podophyllotoxin; Tumor Cells, Cultured | 1998 |
A novel podophyllotoxin-derived compound GL331 is more potent than its congener VP-16 in killing refractory cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Death; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Etoposide; Humans; Neoplasms; Podophyllotoxin; Tumor Cells, Cultured | 1999 |
High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Child; Child, Preschool; Chlorambucil; Cohort Studies; Combined Modality Therapy; Cytarabine; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Incidence; Infant; Leukemia, Myeloid; Life Tables; Lomustine; Male; Mechlorethamine; Melphalan; Middle Aged; Myelodysplastic Syndromes; Neoplasms, Second Primary; Podophyllotoxin; Prednisolone; Prednisone; Procarbazine; Retrospective Studies; Risk; Salvage Therapy; Vinblastine; Vincristine | 1999 |
Feasibility and toxicity of high-dose chemotherapy supported by peripheral blood stem cell transplantation in elderly patients (>/=60 years) with non-Hodgkin's lymphoma: comparison with patients <60 years treated within the same protocol.
Topics: Adolescent; Adult; Age Factors; Aged; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Cytarabine; Disease Progression; Etoposide; Female; Graft Survival; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Humans; Infections; Lymphoma, Non-Hodgkin; Male; Melphalan; Middle Aged; Podophyllotoxin; Survival Rate; Time Factors; Transplantation Conditioning | 2000 |
Positron emission tomography with [18F]2-fluoro-D-2-deoxyglucose (FDG-PET) predicts relapse of malignant lymphoma after high-dose therapy with stem cell transplantation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Disease-Free Survival; Etoposide; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Male; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Podophyllotoxin; Prognosis; Radiopharmaceuticals; Survival Analysis; Survival Rate; Tomography, Emission-Computed; Transplantation Conditioning; Treatment Outcome; Whole-Body Irradiation | 2002 |
Deoxypodophyllotoxin; the cytotoxic and antiangiogenic component from Pulsatilla koreana.
Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Lewis Lung; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Endothelium, Vascular; Etoposide; Humans; Medicine, East Asian Traditional; Mice; Plant Extracts; Plant Roots; Podophyllotoxin; Ranunculaceae; Tumor Cells, Cultured; Umbilical Veins | 2002 |
High-dose therapy in diffuse large cell lymphoma: results and prognostic factors in 452 patients from the GEL-TAMO Spanish Cooperative Group.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Cytokines; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; L-Lactate Dehydrogenase; Lymphoma, Large B-Cell, Diffuse; Male; Melphalan; Middle Aged; Podophyllotoxin; Prednisone; Prognosis; Radiotherapy, Adjuvant; Remission Induction; Retrospective Studies; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome; Vincristine | 2003 |
An epiisopicropodophyllin aza analogue via palladium-catalyzed pseudo-domino cyclization.
Topics: Aza Compounds; Catalysis; Cyclization; Etoposide; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Palladium; Podophyllotoxin; Stereoisomerism | 2002 |
High-dose CEB vs BEAM with autologous stem cell transplant in lymphoma.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Length of Stay; Lymphoma; Male; Melphalan; Middle Aged; Podophyllotoxin; Prognosis; Retrospective Studies; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome | 2004 |
Synthesis and cytotoxic activity of novel derivatives of 4'-demethylepipodophyllotoxin.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Etoposide; Fluorouracil; Humans; Podophyllotoxin; Structure-Activity Relationship | 2004 |
Novel carbamate derivatives of 4-beta-amino-4'-O-demethyl-4-desoxypodophyllotoxin as inhibitors of topoisomerase II: synthesis and biological evaluation.
Topics: Animals; Antineoplastic Agents; Carbamates; Cell Division; DNA; DNA Damage; Enzyme Inhibitors; Etoposide; G2 Phase; Leukemia L1210; Mice; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2005 |
Ifosfamide, epirubicin, etoposide (IEV) and autologous peripheral blood progenitor cell transplant: a feasible and effective salvage treatment for lymphoid malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Epirubicin; Etoposide; Female; Hodgkin Disease; Humans; Ifosfamide; Lymphoma, Non-Hodgkin; Male; Melphalan; Middle Aged; Mitoxantrone; Multiple Myeloma; Odds Ratio; Peripheral Blood Stem Cell Transplantation; Podophyllotoxin; Recurrence; Remission Induction; Salvage Therapy; Time Factors; Transplantation Conditioning; Treatment Outcome | 2005 |
Tandem high-dose chemotherapy and autologous stem cell transplantation in refractory/relapsed Hodgkin's lymphoma: a monocenter prospective study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Deoxycytidine; Disease-Free Survival; Etoposide; Female; Gemcitabine; Hodgkin Disease; Humans; Ifosfamide; Male; Melphalan; Middle Aged; Peripheral Blood Stem Cell Transplantation; Podophyllotoxin; Prospective Studies; Recurrence; Remission Induction; Retrospective Studies; Salvage Therapy; Survival Rate; Transplantation, Autologous; Vinblastine; Vinorelbine | 2007 |
Seleno-podophyllotoxin derivatives induce hepatoma SMMC-7721 cell apoptosis through Bax pathway.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Shape; Cytochromes c; Etoposide; Humans; Liver Neoplasms; Membrane Potentials; Mitochondria; Molecular Structure; Podophyllotoxin | 2008 |
Reversal of P-glycoprotein-mediated drug efflux by eudesmin from Haplophyllum perforatum and cytotoxicity pattern versus diphyllin, podophyllotoxin and etoposide.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Cell Line, Tumor; Dioxolanes; Drug Resistance, Neoplasm; Etoposide; Furans; Humans; Lignans; Phytotherapy; Plant Extracts; Plant Leaves; Plant Roots; Podophyllotoxin; Rutaceae | 2007 |
Thiols oxidation and covalent binding of BSA by cyclolignanic quinones are enhanced by the magnesium cation.
Topics: Antineoplastic Agents; Benzoquinones; Cations, Divalent; Chelating Agents; DNA Topoisomerases, Type II; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Etoposide; Glutathione; Magnesium Chloride; Models, Molecular; Molecular Structure; Oxidation-Reduction; Podophyllotoxin; Protein Binding; Quinones; Serum Albumin, Bovine; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds; Topoisomerase II Inhibitors | 2008 |
Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.
Topics: Antigens, Neoplasm; Antineoplastic Agents, Phytogenic; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Design; Etoposide; Humans; Podophyllotoxin; Protein Binding | 2008 |
F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system.
Topics: Animals; Binding, Competitive; Biogenic Polyamines; Breast Neoplasms; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Delivery Systems; Etoposide; Female; Humans; Leukemia L1210; Lung Neoplasms; Mice; Mice, Nude; Neoplasms; Podophyllotoxin; Topoisomerase II Inhibitors; Xenograft Model Antitumor Assays | 2008 |
Novel 4 beta-anilino-podophyllotoxin derivatives: design synthesis and biological evaluation as potent DNA-topoisomerase II poisons and anti-MDR agents.
Topics: Aniline Compounds; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Etoposide; Humans; Mice; Neoplasms; Podophyllotoxin; Topoisomerase II Inhibitors; Xenograft Model Antitumor Assays | 2010 |
Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage.
Topics: Antigens, Neoplasm; Antineoplastic Agents; DNA; DNA Cleavage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Stability; Etoposide; Humans; Podophyllotoxin; Protein Binding; Spermine; Structure-Activity Relationship | 2011 |
Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Etoposide; Humans; Neoplasms; Podophyllotoxin; Topoisomerase II Inhibitors | 2011 |
QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells.
Topics: Adenocarcinoma; Antigens, Neoplasm; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Caspase 3; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Etoposide; Flow Cytometry; Humans; Lung Neoplasms; Piperidines; Podophyllotoxin; Poly(ADP-ribose) Polymerases; RNA, Small Interfering; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 2012 |
Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Topoisomerases, Type II; Etoposide; Humans; Molecular Structure; Podophyllotoxin; Polyamines; Topoisomerase II Inhibitors | 2011 |
Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Benzamides; Cell Cycle; Cell Line, Tumor; Comet Assay; DNA Breaks; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Etoposide; Humans; Neoplasms; Podophyllotoxin; Podophyllum | 2012 |
Adva-27a, a novel podophyllotoxin derivative found to be effective against multidrug resistant human cancer cells.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Female; Fluorine Compounds; Glycosides; Humans; Male; Microsomes, Liver; Monosaccharides; Podophyllotoxin; Rats; Rats, Sprague-Dawley; Small Cell Lung Carcinoma; Topoisomerase II Inhibitors | 2012 |
Induction of apoptosis through caspase-independent or caspase-9-dependent pathway in mouse and human osteosarcoma cells by a new nitroxyl spin-labeled derivative of podophyllotoxin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 9; Caspase Inhibitors; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Drug Therapy, Combination; Endodeoxyribonucleases; Etoposide; Humans; Mice; Osteosarcoma; Podophyllotoxin; Spin Labels | 2013 |
Encapsulation of podophyllotoxin and etoposide in biodegradable poly-D,L-lactide nanoparticles improved their anticancer activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; CHO Cells; Cricetinae; Cricetulus; Delayed-Action Preparations; Drug Screening Assays, Antitumor; Etoposide; Humans; Nanoparticles; Neoplasms; Podophyllotoxin; Polyesters | 2014 |
Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cyanides; Drug Screening Assays, Antitumor; Etoposide; Humans; Neoplasms; Podophyllotoxin; Spin Labels; Structure-Activity Relationship | 2014 |
Treatment of high-risk aggressive B-cell non-Hodgkin lymphomas with rituximab, intensive induction and high-dose consolidation: long-term analysis of the R-MegaCHOP-ESHAP-BEAM Trial.
Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cisplatin; Consolidation Chemotherapy; Cyclophosphamide; Cytarabine; Disease Progression; Doxorubicin; Etoposide; Female; Humans; Induction Chemotherapy; Lymphoma, B-Cell; Male; Melphalan; Methylprednisolone; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Podophyllotoxin; Prednisone; Prognosis; Rituximab; Treatment Outcome; Vincristine; Young Adult | 2015 |
Synthesis and biological evaluation of novel podophyllotoxin analogs as antitumor agents.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Etoposide; HeLa Cells; Humans; K562 Cells; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Podophyllotoxin; Structure-Activity Relationship | 2014 |
Activity of the polyamine-vectorized anti-cancer drug F14512 against pediatric glioma and neuroblastoma cell lines.
Topics: Animals; Antineoplastic Agents; Carboplatin; Cell Line, Tumor; Cell Survival; Cisplatin; Etoposide; Female; Glioma; Humans; Liver Neoplasms; Melphalan; Mice, Inbred BALB C; Neuroblastoma; Podophyllotoxin; Radiation, Ionizing; Spermine | 2014 |
Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; DNA Breaks, Double-Stranded; DNA Topoisomerases, Type II; Etoposide; Humans; Leukemia; Molecular Docking Simulation; Mustard Compounds; Neoplasms; Podophyllotoxin; Topoisomerase II Inhibitors | 2014 |
Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs.
Topics: Antineoplastic Agents; Binding Sites; Cell Proliferation; Cell Survival; DNA Topoisomerases, Type II; Drug Design; Drug Screening Assays, Antitumor; Etoposide; Humans; Inhibitory Concentration 50; Intercalating Agents; K562 Cells; Molecular Docking Simulation; Molecular Structure; Piperazines; Podophyllotoxin; Protein Binding; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2015 |
PLANT BIOCHEMISTRY. Fighting cancer while saving the mayapple.
Topics: Etoposide; Genetic Engineering; Mixed Function Oxygenases; Nicotiana; Podophyllotoxin; Podophyllum peltatum; Topoisomerase Inhibitors | 2015 |
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
Topics: Amino Acid Sequence; Biosynthetic Pathways; Etoposide; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Genetic Engineering; Methylation; Mixed Function Oxygenases; Molecular Sequence Data; Nicotiana; Podophyllotoxin; Podophyllum peltatum; Topoisomerase Inhibitors; Transcriptome | 2015 |
Novel Etoposide Analogue Modulates Expression of Angiogenesis Associated microRNAs and Regulates Cell Proliferation by Targeting STAT3 in Breast Cancer.
Topics: Apoptosis; Breast Neoplasms; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Damage; Enzyme Activation; Etoposide; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; MCF-7 Cells; MicroRNAs; Models, Molecular; Molecular Docking Simulation; Neovascularization, Pathologic; Podophyllotoxin; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Quinazolines; RNA Interference; RNA, Small Interfering; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A | 2015 |
A Highly Efficient Approach To Construct (epi)-Podophyllotoxin-4-O-glycosidic Linkages as well as Its Application in Concise Syntheses of Etoposide and Teniposide.
Topics: Antineoplastic Agents; Catalysis; Etoposide; Glycosides; Glycosylation; Molecular Structure; Podophyllotoxin; Teniposide | 2016 |
Cytotoxic activity of a synthetic deoxypodophyllotoxin derivative with an opened D-ring.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Etoposide; HEK293 Cells; HeLa Cells; Humans; Inhibitory Concentration 50; Microtubules; Molecular Structure; Podophyllotoxin; Tubulin | 2016 |
Antitumor effect of Deoxypodophyllotoxin on human breast cancer xenograft transplanted in BALB/c nude mice model.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Intravenous; Animals; Antineoplastic Agents, Phytogenic; beta-Cyclodextrins; Breast Neoplasms; Cell Line, Tumor; Docetaxel; Drugs, Chinese Herbal; Etoposide; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Podophyllotoxin; Taxoids; Xenograft Model Antitumor Assays | 2016 |
VIP (etoposide, ifosfamide, and cisplatin) in patients with previously treated soft tissue sarcoma.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Survival; Etoposide; Female; Humans; Ifosfamide; Male; Middle Aged; Podophyllotoxin; Retrospective Studies; Sarcoma; Soft Tissue Neoplasms; Young Adult | 2017 |
Investigation of the anti-angiogenesis effects induced by deoxypodophyllotoxin-5-FU conjugate C069 against HUVE cells.
Topics: Angiogenesis Inhibitors; beta Catenin; Cell Movement; Cell Proliferation; Cell Survival; Down-Regulation; Drugs, Chinese Herbal; Etoposide; Fluorouracil; Human Umbilical Vein Endothelial Cells; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neovascularization, Physiologic; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt | 2017 |
Induction of apoptotic DNA fragmentation mediated by mitochondrial pathway with caspase-3-dependent BID cleavage in human gastric cancer cells by a new nitroxyl spin-labeled derivative of podophyllotoxin.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes c; DNA Fragmentation; Etoposide; Fluorouracil; Humans; Mitochondria; Podophyllotoxin; Spin Labels; Stomach Neoplasms | 2017 |
A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; DNA Damage; Dose-Response Relationship, Drug; Etoposide; Gene Expression Regulation, Leukemic; High-Throughput Screening Assays; Humans; Leukocytes; Podophyllotoxin; Proto-Oncogene Proteins c-myb; Signal Transduction; Small Molecule Libraries; Teniposide | 2018 |
Acid-controlled release complexes of podophyllotoxin and etoposide with acyclic cucurbit[n]urils for low cytotoxicity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Etoposide; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Macrocyclic Compounds; Molecular Structure; Optical Imaging; Podophyllotoxin; Structure-Activity Relationship | 2019 |
BEAM versus BUCYVP16 Conditioning before Autologous Hematopoietic Stem Cell Transplant in Patients with Hodgkin Lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Carmustine; Cyclophosphamide; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Male; Melphalan; Middle Aged; Podophyllotoxin; Transplantation Conditioning; Young Adult | 2019 |
Enzymatic
Topics: Amino Acid Sequence; Amino Acids; Arabidopsis; Biocatalysis; Etoposide; Glycosylation; Glycosyltransferases; Phylogeny; Podophyllotoxin; Substrate Specificity | 2019 |
A Novel Cytotoxic Conjugate Derived from the Natural Product Podophyllotoxin as a Direct-Target Protein Dual Inhibitor.
Topics: Aldehydes; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Products; Cell Line, Tumor; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Etoposide; Humans; Molecular Docking Simulation; Podophyllotoxin; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2020 |
Triazole/thiadiazole substituted 4'-demethylepipodophyllotoxin derivatives induced apoptosis in HeLa cells by up-regulating TMEM133.
Topics: Animals; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Checkpoints; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; Etoposide; Female; Gene Expression Regulation; Gene Knockout Techniques; HeLa Cells; Histones; Humans; Male; Mice, Inbred C57BL; Podophyllotoxin; Thiadiazoles; Triazoles; Up-Regulation | 2021 |
BeEAM conditioning regimen is a safe, efficacious and economical alternative to BEAM chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Melphalan; Middle Aged; Neoplasms; Outcome Assessment, Health Care; Podophyllotoxin; Transplantation Conditioning | 2021 |
Design, semi-synthesis and bioactivity evaluation of novel podophyllotoxin derivatives as potent anti-tumor agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Etoposide; Humans; Phosphatidylinositol 3-Kinases; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Tubulin | 2022 |