podophyllotoxin has been researched along with colchicine in 234 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 141 (60.26) | 18.7374 |
| 1990's | 35 (14.96) | 18.2507 |
| 2000's | 23 (9.83) | 29.6817 |
| 2010's | 31 (13.25) | 24.3611 |
| 2020's | 4 (1.71) | 2.80 |
| Authors | Studies |
|---|---|
| Ishiguro, T; Kishi, T; Koga, K; Komeshima, N; Mizuguchi, H; Tanida, S; Tashiro, T; Tomioka, K; Tsukagoshi, S; Tsuruo, T | 1 |
| Hansch, C; Khwaja, TA; Selassie, CD | 1 |
| Jurd, L; Narayanan, VL; Paull, KD | 1 |
| Brown, E; Guenard, D; Robin, JP; Zavala, F | 1 |
| Autry, C; Chang, JJ; Chen, K; Estes, JR; Hamel, E; Konoshima, T; Kozuka, M; Li, L; Lin, CM; Shi, Q | 1 |
| Hamel, E; Kuo, SC; Lee, KH; Li, L; Lin, CM; Mauger, A; Wang, HK; Wu, TS | 1 |
| Hamel, E; Kuo, SC; Lednicer, D; Lee, KH; Li, L; Lin, CM; Wang, HK; Wu, TS | 1 |
| Chai, H; Cruz, JG; Hernández, L; Mar, W; Novelo, M; Pereda-Miranda, R; Pezzuto, JM | 1 |
| Chang, JJ; Hamel, E; Juang, JP; Kuo, SC; Lednicer, D; Lee, HZ; Lin, CM; Lin, YT; Paull, KD; Wu, TS | 1 |
| Chen, K; Hamel, E; Hsieh, MC; Kuo, SC; Lee, KH; Lin, CM; Mauger, A | 2 |
| Goldbrunner, M; Loidl, G; Mannschreck, A; Polossek, T; von Angerer, E | 1 |
| Bastow, KF; Hackl, T; Hamel, E; Kuo, SC; Lee, KH; Tachibana, Y; Xia, P; Xia, Y; Yang, ZY | 1 |
| Bastow, KF; Brossi, A; Guan, J; Hamel, E; Lee, KH; Tachibana, Y; Zhu, XK | 1 |
| Beutler, JA; Boyd, MR; Cardellina, JH; Haemers, A; Hamel, E; Rajan, P; Roitman, JN; Vlietinck, AJ | 1 |
| Bastow, K; Hamel, E; Hour, MJ; Huang, LJ; Kuo, SC; Lee, KH; Nakanishi, Y; Xia, Y | 1 |
| Bastow, KF; Hackl, T; Hamel, E; Hour, MJ; Kuo, SC; Lee, HK; Nakanishi, Y; Namrpoothiri, P; Xia, P; Xia, Y; Yang, ZY | 1 |
| Hackl, T; Hamel, E; Lee, KH; Mauger, A; Wu, JH; Xia, P; Xia, Y; Yang, ZY | 1 |
| Burger, AM; Camacho Gomez, JA; Düssmann, H; Günther, EG; Hirano, T; Ishii, Y; Prehn, JH; Prinz, H; Schmidt, P; Stoiber, T; Umezawa, K; Unger, E | 1 |
| Fang, X; Shao, L; Wang, S; Zhang, H | 1 |
| Dalrymple, S; Hallur, G; Hamel, E; Hidalgo, M; Isaacs, JT; Jimeno, A; Jung, MK; Khan, SR; Sukumar, S; Zhu, T | 1 |
| Bär, T; Beckers, TL; Eichhorn, E; Höcher, H; Mahboobi, S; Maier, T; Schmidt, M; Sellmer, A; Stadlwieser, JF | 1 |
| Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Prinz, H; Schmidt, P; Unger, E; Zuse, A | 2 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Kornienko, A; Magedov, IV; Manpadi, M; Przheval'skii, NM; Rogelj, S; Rozhkova, E; Slambrouck, SV; Steelant, WF | 1 |
| Nussbaumer, P; Winiski, AP | 1 |
| Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Prinz, H; Schmidt, P; Unger, E | 2 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Lee, KH | 1 |
| Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Nickel, HC; Prinz, H; Schmidt, P; Unger, E | 1 |
| Böhm, KJ; Müller, K; Prinz, H; Surkau, G | 1 |
| Khagga, M; Pallapothula, VR; Palle, S; Ramanatham, V; Reddy, PS; Vantikommu, J | 1 |
| Aicher, B; Amon, P; Böhm, KJ; Chamasmani, B; Gerlach, M; Günther, EG; Ivanov, I; Müller, K; Prinz, H; Vogel, K | 1 |
| Bhoga, Ud; Evdokimov, NM; Fernandes, MA; Frolova, L; George, O; Georgiou, KH; Getlik, M; Kinnibrugh, TL; Kornienko, A; Magedov, IV; Manpadi, M; Renner, S; Rogelj, S; Shuster, CB; Steelant, WF; Tang, H; van Otterlo, WA; Van slambrouck, S | 1 |
| Cao, H; Cheng, W; Han, C; Li, X; Liu, Y; Lu, Y; Ma, Y; Wei, D; Wei, Y; Zhao, C; Zhao, Y | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Akula, B; Bharathi, EV; Billa, VK; Cosenza, SC; Gallo, JM; Lv, H; Mallireddigari, MR; Padgaonkar, A; Pallela, VR; Reddy, EP; Reddy, MV; Subbaiah, DR | 1 |
| Camarasa, MJ; Canela, MD; Díaz, JF; Liekens, S; Noppen, S; Pérez-Pérez, MJ; Priego, EM; Sáez-Calvo, G | 1 |
| Brett, ML; Colley, HE; Coole, SF; Danson, SJ; Dossetter, AG; Griffen, EJ; Harrison, J; Jackson, LV; Jennings, LR; Lockey, PM; Mason, DP; Muthana, M; Norman, D; Thompson, MJ; Tulasi, V; Williams, L; Wong, M | 1 |
| Han, HW; Hu, C; Lu, GH; Qi, JL; Qiu, HY; Sun, WX; Wang, XM; Yang, RW; Yang, YH | 1 |
| Aghaee, E; Böhm, KJ; Ghasemi, JB; Ivanov, I; Müller, K; Prinz, H; Ridder, AK; Vogel, K | 1 |
| Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR | 1 |
| Han, HW; Ji, YJ; Lin, HY; Lu, GH; Qi, JL; Sun, WX; Wan, Y; Wang, XM; Yang, YH | 1 |
| Briguglio, I; Carta, A; Corona, P; Fermeglia, M; Laurini, E; Piras, S; Pirisi, MA; Pricl, S | 1 |
| Bueno, O; Camarasa, MJ; Díaz, JF; Estévez-Gallego, J; Liekens, S; Noppen, S; Pérez-Pérez, MJ; Priego, EM; Quesada, E; Tobajas, G | 1 |
| Carda, M; Falomir, E; Marco, JA; Marzo-Mas, A; Murga, J | 1 |
| Behera, C; Chanda, D; Fatima, K; Gupta, AK; Hasanain, M; Khwaja, S; Kour, A; Luqman, S; Mondhe, DM; Negi, AS; Sarkar, J; Shanker, K; Singh, A | 1 |
| He, L; Tang, YJ; Xiang, TL; Zhao, W | 1 |
| Bueno, O; Camarasa, MJ; Díaz, JF; Estévez-Gallego, J; Gargantilla, M; Liekens, S; Martins, S; Pérez-Pérez, MJ; Priego, EM | 1 |
| Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR | 1 |
| Kislyi, VP; Maksimenko, AS; Semenov, VV; Semenova, MN; Stroylov, VS; Svitanko, IV | 1 |
| Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR | 1 |
| Itkin, M; Kabir, M; Mathé, EA; Nguyễn, ÐT; Padilha, EC; Shah, P; Shinn, P; Siramshetty, V; Wang, AQ; Williams, J; Xu, X; Yu, KR; Zhao, T | 1 |
| Chen, TT; Kong, LY; Leng, JF; Yan, XY; Yin, Y; Zhao, YJ | 1 |
| Davidse, LC; Flach, W | 1 |
| Bhattacharyya, B; Cortese, F; Wolff, J | 1 |
| Cherry, WR; Clavin, SA; Hull, RN; Huseby, RM | 1 |
| Grunspan-Swirsky, A; Pick, E | 1 |
| Kerkut, GA | 1 |
| McClure, WO; Paulson, JC | 4 |
| Banks, P; Till, R | 1 |
| Grieder, A; Maurer, R; Stähelin, H | 1 |
| von Krogh, G | 2 |
| Edström, A; Hanson, M | 1 |
| Dahlström, A; Heiwall, PO; Larsson, PA | 1 |
| Kelleher, JK | 2 |
| O'Hare, MJ | 1 |
| Golbetz, H; Maffly, R; Mamelak, M; Taylor, A | 1 |
| Hisata, T; Katsufuji, N; Tatibana, M | 1 |
| Labourdette, G; Marks, A | 1 |
| Bray, D; Shaw, G; Thomas, C | 1 |
| Deanin, GG; Gordon, MW; Thompson, WC | 1 |
| Friedkin, M; Legg, A; Rozengurt, E | 1 |
| Pick, E; Wilner, I | 1 |
| Cox, PJ; Farmer, PB | 1 |
| Matsumoto, G; Sakai, H | 1 |
| Sandoval, IV; Weber, K | 1 |
| Raff, EC | 1 |
| Kupchan, SM; Rebhum, LI; Wang, RW | 1 |
| Cheng, Y; Miller, MD; Reaven, EP | 1 |
| Houston, LL; McChesney, JD; Murray, RJ; Pazdernik, TL; Smissman, EE | 1 |
| Asnes, CF; Pfeffer, TA; Wilson, L | 1 |
| Geel, SE; Gonzales, LW | 1 |
| Misra, NC; Roberts, DW | 1 |
| Aubin, JE; Carlsen, SA; Ling, V | 1 |
| Bhattacharyya, B; Wolff, J | 2 |
| Wilson, L | 3 |
| Maffly, R; Reaven, E; Taylor, A; Wilson, L | 1 |
| Bhattacharyya, B; Volff, J | 1 |
| Hoebeke, J; Nijen, GV | 1 |
| Betel, I; Martijnse, J | 1 |
| Chène, P; Mazarguil, H; Wright, M | 1 |
| Hahn, KM; Hastie, SB; Sundberg, RJ | 1 |
| Marx, KA; Mello, CM | 1 |
| Cahnmann, HJ; Knipling, L; Palumbo, G; Wolff, J | 1 |
| Austin, RC; Dudani, AK; Gupta, RS; Venner, TJ | 1 |
| Iwasaki, S; Ludueña, RF; Prasad, V; Roach, MC; Sullivan, AS; Takahashi, M | 1 |
| Norberg, B | 1 |
| Lacey, E; Russell, GJ | 1 |
| Hamel, E; Ho, HH; Lin, CM; Pettit, GR | 1 |
| Ishida, R; Nishimoto, T; Nishizawa, M; Takahashi, T | 1 |
| Menon, KM; Rajan, VP | 1 |
| Matsumoto, G; Murofushi, H; Sakai, H | 1 |
| Avila, J; Serrano, L; Villanueva, N; Wandosell, F | 1 |
| Yalowich, JC | 1 |
| Beck, WT; Cirtain, MC; Danks, MK; Felsted, RL; Safa, AR; Suttle, DP; Trent, JM; Wolverton, JS | 1 |
| Avivi, L; Dotan, A | 1 |
| Morgan, EH; Sorokin, LM; Yeoh, GC | 1 |
| Batra, JK; Hamel, E; Jurd, L; Kang, GJ | 1 |
| Chu, PS; Dempcy, RO; Hamel, E; Lin, CM; Pettit, GR; Schmidt, JM; Singh, SB | 1 |
| Alcantara, O; Boldt, DH; Phillips, JL | 1 |
| Horowitz, PM; Ludueña, RF; Prasad, AR; Prasad, V | 1 |
| Banerjee, A; Barnes, LD; Luduena, RF | 1 |
| Batra, JK; Hamel, E; Jurd, L | 1 |
| Gupta, RS | 3 |
| Bane, S; Ludueña, RF; Roach, MC | 1 |
| Banerjee, A; Jordan, MA; Luduena, RF | 1 |
| Davis, RE; Klinger, PD; Schlumpf, BE | 1 |
| Langford, GM; Luduena, RF; MacRae, TH; Roach, MC | 1 |
| Whittaker, JR | 1 |
| Margulis, L | 1 |
| Temple, R; Wolff, J | 1 |
| Maffly, R; Mamelak, M; Reaven, E; Taylor, A | 1 |
| Flavin, M; Slaughter, C | 1 |
| Stone, M; van den Brenk, HA | 1 |
| Eng, LF; Pratt, D; Wilson, L | 1 |
| Edelman, GM; Yahara, I | 1 |
| Chignell, CF; Zweig, MH | 1 |
| Meza, I; Wilson, L | 1 |
| Bamburg, JR; Creswell, KM; Grisham, LM; Mizel, SB; Wilson, L | 1 |
| De la Llosa-Hermier, MP; Hermier, C; Saltarelli, D; Tertrin-Clary, C | 1 |
| Carney, DH; Crossin, KL | 1 |
| Hamel, E; Lin, CM | 1 |
| Watanabe, K; West, WL | 1 |
| Fujii, T; Kondo, Y; Kumasaka, M; Ohki, K; Suzuki, T | 1 |
| Christen, P; Jaussi, R; Skoda, RC | 1 |
| Ichikawa, M; Matsumoto, G; Murofushi, H; Sakai, H; Tasaki, A | 1 |
| Hanson, M | 1 |
| Bennett, EL; Flood, JF; Jarvik, ME; Landry, DW | 1 |
| Seif, R | 1 |
| Iida, K; Natori, S; Yahara, I | 1 |
| Ludueña, RF; Roach, MC | 2 |
| Brunet, C; Cazin, M; Luyckx, M | 1 |
| Morgan, JL; Spooner, BS | 1 |
| Oka, JA; Weigel, PH | 1 |
| Kaufman, SS; Sorrell, MF; Tuma, DJ; Vanderhoof, JA | 1 |
| Gupta, R; Gupta, RS | 1 |
| Ichikawa, M; Matsumoto, G; Tasaki, A | 1 |
| Ludueña, RF; Palanivelu, P | 1 |
| Farrell, KW; Jordan, MA | 1 |
| Geller, RL; Lilien, J | 1 |
| Banerjee, AC; Bhattacharyya, B; Biswas, BB | 1 |
| Chalfie, M; Thomson, JN | 1 |
| Na, GC; Timasheff, SN | 1 |
| Andreu, JM; Timasheff, SN | 1 |
| Silverstein, SC; Wright, SD | 1 |
| Kredich, NM; Pike, MC; Snyderman, R | 1 |
| Bernstam, VA; Bernstein, IA; Gray, RH | 1 |
| Watts, SD | 1 |
| Schrek, R; Stefani, SS | 1 |
| Grenier, JF; Launay, JF; Stock, C | 1 |
| Phaire-Washington, L; Silverstein, SC; Wang, E | 1 |
| Ludueña, RF; Myles, DG; Pfeffer, TA | 1 |
| Allam, N; Breillout, F; Debal, V; Gourdier, B; Manfait, M; Millot, JM; Morjani, H | 1 |
| Kamiguchi, Y; Mikamo, K; Shimada, M; Sugawara, S; Tateno, H | 1 |
| Knipling, L; Wolff, J | 1 |
| Lu, Q; Luduena, RF | 1 |
| Ludueña, RF; Pettit, GR; Prasad, V; Roach, MC | 1 |
| Hamel, E; Lee, KH; Lin, CM; Paull, KD; Plowman, J; Wang, HK | 1 |
| D'Amato, RJ; Flynn, E; Hamel, E; Lin, CM | 1 |
| Cordell, GA; Kingston, DG; Neidigh, KA; Pengsuparp, T; Pezzuto, JM | 1 |
| Denyer, SP; Hammonds, TR; Irving, WL; Jackson, DE | 1 |
| Ackerman-Morris, S; Bollenbacher, WE; Smith, WA; Watson, CJ; Watson, RD | 1 |
| Day, BW; Hamel, E; Rosenkranz, HS; ter Haar, E | 1 |
| Andreu, JM; Dumortier, C; Engelborghs, Y; Gorbunoff, MJ | 1 |
| Basu, A; Haldar, S | 1 |
| Jordan, MA; Wilson, L | 1 |
| Chaudhuri, AR; Curcio, M; Ludueña, RF; Mizuhashi, F; Murata, K; Prasad, V; Tomita, I | 1 |
| Hagen, K; Kong, AN; Mandlekar, S; Roninson, IB; Shtil, AA; Tan, TH; Walter, RJ; Yu, R | 1 |
| Kovar, P; Ng, SC; Rosenberg, SH; Tahir, SK | 1 |
| Chaudhuri, AR; Hausheer, FH; Ludueña, RF; Schwarz, PM; Seetharamalu, P | 1 |
| Cande, WZ; Cowan, CR | 1 |
| KROUTIL, M; LENFELD, J; ZEMANEK, J | 2 |
| BELLONI, F; VERGA, L | 1 |
| DAVISON, C; MILLER, ZB; SMITH, PK | 1 |
| Burnett, JC; Day, BW; Gussio, R; Hamel, E; Hermone, AR; McGrath, C; Nguyen, TL; Wipf, P; Zaharevitz, DW | 1 |
| Danieli, B; Giardini, A; Lesma, G; Passarella, D; Peretto, B; Pratesi, G; Sacchetti, A; Silvani, A; Zunino, F | 1 |
| Bhattacharyya, B; Das, L; Datta, AB; Gupta, S; Janik, ME; Poddar, A | 1 |
| Han, CK; Kim, DY; Kim, KH; Kim, ND; Lee, KY; Lee, SS; Moon, SK; Seong, BL; Yoon, JH | 1 |
| Cormier, A; Gigant, B; Knossow, M; Wang, C | 1 |
| Borlak, J; Cappelletti, G; Cartelli, D; Danieli, B; Fontana, G; Giardini, A; Passarella, D; Peretto, B; Ronchi, C; Sacchetti, A; Silvani, A | 1 |
| Blasco y Yepes, R; Borlak, J; Cappelletti, G; Cartelli, D; Danieli, B; Fontana, G; Passarella, D; Peretto, B; Ronchi, C; Snaith, J | 1 |
| Ahn, S; Dalton, JT; Li, CM; Lu, Y; Miller, DD; Narayanan, R | 1 |
| Akhmanova, A; Doodhi, H; Kapitein, LC; Katrukha, EA; Meijering, E; Mohan, R; Smal, I; Steinmetz, MO | 1 |
| Bai, JK; Chen, T; Li, HM; Tang, YJ; Zhao, W | 1 |
| Andricopulo, AD; da Fonseca, MB; Graebin, CS; Magalhaes, LG; Marques, FB; Rogério, KR | 1 |
| Alvarez, L; Antúnez-Mojica, M; Barasoain, I; Cañada, FJ; Canales, Á; Díaz, JF; Jiménez-Barbero, J; León, A; Redondo-Horcajo, M; Rodríguez-Salarichs, J | 1 |
| Banerjee, S; Kelleher, JK; Kerrr, V; Margulis, L; Winston, M | 1 |
| Bryan, J | 1 |
| van Os, FH | 1 |
| Seidenglanz, G | 1 |
| Medel, M; Prager, R; Zipper, J | 1 |
| Banerjee, S; Margulis, L | 1 |
| Mizel, SB; Wilson, L | 1 |
| Bettley, FR | 1 |
| Cardinali, G; Gedda, L | 1 |
| Shelanski, ML; Terry, RD; Wisniewski, H | 1 |
| Friedkin, M; Wilson, L | 1 |
| KLINE, TS | 1 |
| DUSTIN, P | 1 |
| JOHN, AC; LENNETTE, EH; SPENDLOVE, RS | 1 |
| BELISARIO, JC | 1 |
| GOLDENBERG, DM | 1 |
| DOGLIOTTI, GC | 1 |
| KELLNER, B; SUGAR, J | 1 |
| MERCIER-PAROT, L; TUCHMANN-DUPLESSIS, H | 1 |
| CHIN, JN; KNIGHT, CO; LENNETTE, EH; SPENDLOVE, RS | 1 |
| ISLER, H | 1 |
| Chen, T; Li, HM; Liang, XH; Tang, YJ; Tang, YL; Yang, Y; Zhang, YX; Zhao, W; Zhou, C | 1 |
15 review(s) available for podophyllotoxin and colchicine
| Article | Year |
|---|---|
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
Topics: Anti-HIV Agents; Biological Factors; Drug Design; Molecular Structure; Pharmaceutical Preparations; Plants, Medicinal | 2010 |
Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability.
Topics: Administration, Oral; Animals; Betamethasone; Biological Availability; Caco-2 Cells; Cell Membrane Permeability; Cells, Cultured; Dexamethasone; Dogs; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Madin Darby Canine Kidney Cells; Mice; Molecular Structure; Neural Networks, Computer; Ranitidine; Rats; Structure-Activity Relationship; Verapamil | 2022 |
Axoplasmic transport.
Topics: Animals; Axonal Transport; Axons; Biological Transport; Colchicine; Kinetics; Models, Biological; Podophyllotoxin; Synaptic Vesicles; Synaptosomes; Time Factors; Vinblastine; Vincristine | 1975 |
Mitosis inhibitors and axonal transport.
Topics: Anesthetics; Animals; Axonal Transport; Colchicine; Deuterium; Griseofulvin; Herbicides; Invertebrates; Mammals; Melatonin; Mescaline; Microtubules; Mitosis; Nerve Tissue Proteins; Neurons; Optic Nerve; Podophyllotoxin; Sciatic Nerve; Synaptic Transmission; Vagus Nerve; Vinblastine; Vincristine | 1978 |
Towards selectivity? Approaches to the design of new anti-tumour agents--II.
Topics: Altretamine; Amino Acids; Antineoplastic Agents; Carbohydrates; Chelating Agents; Colchicine; Coloring Agents; Dacarbazine; Daunorubicin; Doxorubicin; Drug Interactions; Ellipticines; Folic Acid Antagonists; Heart Diseases; Humans; Lectins; Neoplasms; Nitrosourea Compounds; Peptide Hydrolases; Podophyllotoxin; Polymers; Structure-Activity Relationship | 1977 |
Microtubules as drug receptors: pharmacological properties of microtubule protein.
Topics: Animals; Binding Sites; Biological Transport; Brain; Chick Embryo; Colchicine; HeLa Cells; Kinetics; Microtubules; Nucleosides; Podophyllotoxin; Protein Binding; Receptors, Drug; Tubulin; Vinblastine; Vinca Alkaloids | 1975 |
Evidence for involvement of microtubules in the action of vasopressin.
Topics: Animals; Anura; Biological Transport; Colchicine; Epithelial Cells; Epithelium; In Vitro Techniques; Microtubules; Podophyllotoxin; Sodium; Tubulin; Urinary Bladder; Vasopressins; Vinblastine; Water | 1975 |
Action of drugs on microtubules.
Topics: Animals; Binding Sites; Binding, Competitive; Colchicine; Depression, Chemical; Griseofulvin; Microtubules; Mitosis; Podophyllotoxin; Species Specificity; Tubulin; Vinblastine; Vinca Alkaloids | 1975 |
Role of microtubules and axolinin in membrane excitation of the squid giant axon.
Topics: Alkaloids; Animals; Axons; Calcium; Cell Membrane; Colchicine; Cyclic AMP; Cytoskeleton; Decapodiformes; Intracellular Fluid; Membrane Potentials; Microtubule-Associated Proteins; Microtubules; Nerve Tissue Proteins; Paclitaxel; Peptide Synthases; Podophyllotoxin; Sodium; Sulfhydryl Reagents; Tubulin | 1985 |
Colchicine-sensitive microtubules.
Topics: Actins; Cell Movement; Cell Nucleus; Chromosomes; Cilia; Ciliophora; Colchicine; Cytogenetics; Flagella; Griseofulvin; Microtubules; Mitosis; Motion Pictures; Muscle Proteins; Mutation; Niacinamide; Nucleotides; Organoids; Podophyllotoxin; Regeneration; Riboflavin; Triticum; Vinblastine | 1973 |
[Agents affecting cytoskeletal proteins].
Topics: Actins; Animals; Colchicine; Cytochalasins; Cytoskeleton; Mice; Mice, Inbred C3H; Microtubules; Podophyllotoxin; Tubulin | 1983 |
Tubulin and the microtubule system in cellular growth and development.
Topics: Animals; Cell Division; Colchicine; Griseofulvin; Microtubule-Associated Proteins; Microtubules; Mitosis; Nerve Tissue Proteins; Plant Physiological Phenomena; Podophyllotoxin; Proteins; Tubulin; Vinblastine; Vincristine | 1981 |
[Plants with cytostatic effect].
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Nucleus; Cell Transformation, Neoplastic; Colchicine; Colchicum; DNA; Drug Synergism; Glutamine; Glycolysis; Humans; Leukemia; Mercaptopurine; Methotrexate; Mitosis; Neoplasms; Plant Extracts; Plants, Medicinal; Plants, Toxic; Podophyllum; Prednisone; Purines; Pyrimidines; RNA; Steroids; Vincristine | 1970 |
[Chemotherapy of malignant tumors. 44].
Topics: Adrenal Cortex Hormones; Alkylating Agents; Androgens; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Azirines; Carbamates; Colchicine; Dichlorodiphenyldichloroethane; Esters; Estrogens; Ethers, Cyclic; Ethylamines; Excitatory Amino Acid Antagonists; Folic Acid Antagonists; Heterocyclic Compounds; Hormones; Hydrazines; Mannitol; Neoplasms; Phytotherapy; Pipobroman; Plants, Medicinal; Plants, Toxic; Podophyllum; Purines; Pyrimidines; Sulfonic Acids; Triazines; Vinblastine; Vincristine | 1970 |
NEW ASPECTS OF THE PHARMACOLOGY OF ANTIMITOTIC AGENTS.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antimetabolites; Antimitotic Agents; Antineoplastic Agents; Carbamates; Cell Division; Chromosomes; Colchicine; Epinephrine; Griseofulvin; Humans; Lactones; Pharmacology; Podophyllum; Sulfhydryl Compounds; Vinblastine | 1963 |
2 trial(s) available for podophyllotoxin and colchicine
| Article | Year |
|---|---|
Topical treatment of penile condylomata acuminata with podophyllin, podophyllotoxin and colchicine. A comparative study.
Topics: Administration, Topical; Clinical Trials as Topic; Colchicine; Condylomata Acuminata; Drug Evaluation; Humans; Male; Penile Neoplasms; Podophyllin; Podophyllotoxin | 1978 |
Podophyllotoxin for condylomata acuminata eradication. Clinical and experimental comparative studies on Podophyllum lignans, colchicine and 5-fluorouracil.
Topics: Administration, Topical; Animals; Clinical Trials as Topic; Colchicine; Condylomata Acuminata; Ethanol; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Mice; Mice, Hairless; Plants, Medicinal; Plants, Toxic; Podophyllotoxin; Podophyllum; Rabbits; Skin; Skin Neoplasms; Urogenital Neoplasms | 1981 |
217 other study(ies) available for podophyllotoxin and colchicine
| Article | Year |
|---|---|
Absolute structure-cytotoxic activity relationships of steganacin congeners and analogues.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Cell Division; Humans; Indicators and Reagents; KB Cells; Lignans; Models, Molecular; Molecular Conformation; Molecular Structure; Structure-Activity Relationship | 1991 |
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models.
Topics: Animals; Antineoplastic Agents; Astrocytoma; Bucladesine; Cell Differentiation; Dioxoles; DNA Topoisomerases, Type I; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Tubulin | 1987 |
Structure--antitubulin activity relationship in steganacin congeners and analogues. Inhibition of tubulin polymerization in vitro by (+/-)-isodeoxypodophyllotoxin.
Topics: Colchicine; Depression, Chemical; Drugs, Chinese Herbal; Kinetics; Podophyllotoxin; Protein Binding; Structure-Activity Relationship; Tubulin | 1980 |
Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Flavonoids; Humans; KB Cells; Magnetic Resonance Spectroscopy; Tubulin; Tumor Cells, Cultured | 1995 |
Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.
Topics: Animals; Antineoplastic Agents; Cattle; Colchicine; Humans; Microtubules; Molecular Structure; Polymers; Pyrrolidines; Quinolones; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 1994 |
Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Small Cell; Cattle; Cell Division; Central Nervous System Neoplasms; Colonic Neoplasms; Female; Humans; Leukemia; Lung Neoplasms; Molecular Structure; Polymers; Quinolones; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 1994 |
Cytotoxic constituents from Hyptis verticillata.
Topics: Animals; Antineoplastic Agents, Phytogenic; Artemia; Candida albicans; Drug Screening Assays, Antitumor; Humans; Leukemia P388; Mexico; Mice; Microbial Sensitivity Tests; Plants, Medicinal; Podophyllotoxin; Rats | 1993 |
Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.
Topics: Animals; Antineoplastic Agents; Humans; Intestinal Neoplasms; Leukemia L1210; Leukemia P388; Lung Neoplasms; Melanoma; Mice; Molecular Structure; Nasopharyngeal Neoplasms; Quinolines; Quinolones; Software; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 1993 |
Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Screening Assays, Antitumor; Female; Humans; Indicators and Reagents; KB Cells; Magnetic Resonance Spectroscopy; Male; Mice; Naphthyridines; Software; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured | 1997 |
Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.
Topics: Antineoplastic Agents; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Female; Humans; Indicators and Reagents; Macromolecular Substances; Male; Molecular Structure; Naphthyridines; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured | 1997 |
Inhibition of tubulin polymerization by 5,6-dihydroindolo[2,1-alpha]isoquinoline derivatives.
Topics: Animals; Antineoplastic Agents; Cattle; Colchicine; Humans; Indoles; Isoquinolines; Magnetic Resonance Spectroscopy; Molecular Structure; Polymers; Protein Binding; Spectrophotometry, Infrared; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 1997 |
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Topics: Antibiotics, Antineoplastic; Humans; Quinolones; Tubulin; Tumor Cells, Cultured | 1998 |
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
Topics: Antineoplastic Agents; Cell Division; Colchicine; DNA; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; KB Cells; Topoisomerase II Inhibitors; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 1998 |
Structure-activity requirements for flavone cytotoxicity and binding to tubulin.
Topics: Antineoplastic Agents, Phytogenic; Biopolymers; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Flavonoids; Humans; Protein Binding; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured | 1998 |
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Topics: Antineoplastic Agents; Biopolymers; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Pyrrolidines; Quinazolines; Quinazolinones; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 2000 |
Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones.
Topics: Anti-HIV Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; HIV Infections; Humans; Lymphocytes; Quinazolines; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured | 2001 |
Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.
Topics: Antineoplastic Agents; Biopolymers; Drug Screening Assays, Antitumor; Humans; Mitosis; Pyrroles; Quinolones; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured | 2001 |
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Biopolymers; Blotting, Western; Cell Cycle; Cell Survival; Drug Screening Assays, Antitumor; Humans; K562 Cells; Microscopy, Electron; Structure-Activity Relationship; Tubulin | 2003 |
CHMIS-C: a comprehensive herbal medicine information system for cancer.
Topics: Antineoplastic Agents, Phytogenic; Databases, Factual; Internet; National Institutes of Health (U.S.); Neoplasms; Phytotherapy; Plant Preparations; United States; United States Food and Drug Administration | 2005 |
Benzoylphenylurea sulfur analogues with potent antitumor activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Phenylurea Compounds; Pyrimidines; Structure-Activity Relationship; Tubulin Modulators | 2006 |
[4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines.
Topics: Aniline Compounds; Binding Sites; Cell Line, Tumor; Cell Shape; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Humans; Structure-Activity Relationship; Thiazoles; Tubulin; Tubulin Modulators | 2006 |
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Proliferation; Cell Survival; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Flow Cytometry; Humans; Inhibitory Concentration 50; K562 Cells; Leukemia P388; Mice; Molecular Structure; Structure-Activity Relationship; Thiophenes; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 2006 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 3-Ring; Humans; Lymphocytes; Podophyllotoxin; Pyrazoles; Stereoisomerism; Structure-Activity Relationship | 2007 |
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Topics: Anthracenes; Cell Cycle; Cell Line, Tumor; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Naphthalenes; Nocodazole; Podophyllotoxin; Structure-Activity Relationship; Thiophenes; Tubulin; Tubulin Modulators | 2007 |
Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications.
Topics: Binding Sites; Cell Growth Processes; Cell Line; Colchicine; Humans; Keratinocytes; Microscopy, Fluorescence; Microtubules; Mitosis; Phenols; Protein Kinase Inhibitors; Structure-Activity Relationship; Tubulin | 2008 |
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Topics: Anthracenes; Binding, Competitive; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase; Humans; Protein Binding; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2009 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
Topics: Anthracenes; Antineoplastic Agents; Benzylidene Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Protein Multimerization; Protein Structure, Quaternary; Tubulin | 2010 |
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives.
Topics: Anthracenes; Antineoplastic Agents; Cell Proliferation; Humans; Inhibitory Concentration 50; K562 Cells; Oximes; Protein Multimerization; Protein Structure, Quaternary; Tubulin | 2010 |
Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition.
Topics: Catalysis; Cell Line, Tumor; Copper; Cyclization; Drug Evaluation, Preclinical; Humans; Triazoles | 2010 |
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Topics: Antineoplastic Agents; Biopolymers; Cell Cycle; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Organ Specificity; Oxazines; Phenothiazines; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2011 |
Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.
Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Computer Simulation; HeLa Cells; Heterocyclic Compounds; Humans; Indoles; Models, Molecular; Molecular Mimicry; Naphthalenes; Podophyllotoxin; Pyrazoles; Pyridines; Small Molecule Libraries; Stereoisomerism; Tubulin Modulators | 2011 |
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Topics: Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Microtubules; Molecular Structure; Schiff Bases; Stereoisomerism; Structure-Activity Relationship; Tubulin | 2011 |
Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; Humans; K562 Cells; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 2012 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Blood-Brain Barrier; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Drug Design; Drug Resistance, Neoplasm; HCT116 Cells; Humans; K562 Cells; MCF-7 Cells; Mice; Mice, Nude; Microtubules; Neoplasms; Polymerization; Sulfonamides; Tubulin; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach.
Topics: Antineoplastic Agents; Binding Sites; Cell Cycle; Cell Proliferation; Cells, Cultured; Colchicine; Cyclohexanones; Drug Evaluation, Preclinical; Drug Stability; Humans; Neoplasm Invasiveness; Spindle Apparatus; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2014 |
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer.
Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Cell Proliferation; Drug Screening Assays, Antitumor; Head and Neck Neoplasms; Heterografts; Humans; Indoles; Male; Mice; Mice, Nude; Microtubules; Neoplasm Transplantation; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2015 |
Design, synthesis and anti-cancer activity evaluation of podophyllotoxin-norcantharidin hybrid drugs.
Topics: Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; MCF-7 Cells; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship | 2016 |
N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization.
Topics: Alkylating Agents; Antineoplastic Agents; Ethylenediamines; G2 Phase Cell Cycle Checkpoints; Humans; K562 Cells; Molecular Docking Simulation; Oxazines; Phenothiazines; Piperazines; Polymerization; Quantitative Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2017 |
Highly predictive and interpretable models for PAMPA permeability.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine | 2017 |
Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents.
Topics: Acetates; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Esters; Humans; MCF-7 Cells; Molecular Structure; Piperazine; Piperazines; Podophyllotoxin; Polymerization; Structure-Activity Relationship; Tubulin | 2017 |
Triazolopyridinyl-acrylonitrile derivatives as antimicrotubule agents: Synthesis, in vitro and in silico characterization of antiproliferative activity, inhibition of tubulin polymerization and binding thermodynamics.
Topics: Acrylonitrile; Antineoplastic Agents; Binding Sites; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Polymerization; Pyridines; Structure-Activity Relationship; Thermodynamics; Triazoles; Tubulin; Tubulin Modulators | 2017 |
Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity.
Topics: Animals; Antineoplastic Agents; Benzodioxoles; Binding Sites; Biomimetics; Cell Line; Cell Proliferation; Chalcones; Drug Design; Endothelial Cells; Humans; Neoplasms; Protein Conformation; Tubulin; Tubulin Modulators | 2018 |
Effects on tubulin polymerization and down-regulation of c-Myc, hTERT and VEGF genes by colchicine haloacetyl and haloaroyl derivatives.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Colchicine; Dose-Response Relationship, Drug; Down-Regulation; Drug Screening Assays, Antitumor; Humans; Hydrocarbons, Halogenated; Molecular Structure; Polymerization; Proto-Oncogene Proteins c-myc; Structure-Activity Relationship; Telomerase; Tubulin; Vascular Endothelial Growth Factors | 2018 |
Antiproliferative efficacy of curcumin mimics through microtubule destabilization.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug Screening Assays, Antitumor; Female; Humans; Male; Mice; Microtubules; Neoplasms | 2018 |
Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain.
Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Cycle Checkpoints; Colchicine; Drug Design; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; Podophyllotoxin; Tubulin; Tubulin Modulators | 2019 |
Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop.
Topics: Antineoplastic Agents; Binding Sites; Cell Cycle; Cell Line; Cell Proliferation; Colchicine; Crystallography, X-Ray; Cyclohexanones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Phenyl Ethers; Structure-Activity Relationship; Tubulin | 2019 |
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility | 2019 |
Computational modeling and target synthesis of monomethoxy-substituted o-diphenylisoxazoles with unexpectedly high antimitotic microtubule destabilizing activity.
Topics: Animals; Binding Sites; Cell Line, Tumor; Embryo, Nonmammalian; Humans; Isoxazoles; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Sea Urchins; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2020 |
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.
Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States | 2020 |
Design, synthesis, and biological evaluation of novel diphenylamine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site.
Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Colchicine; Diphenylamine; Drug Screening Assays, Antitumor; Humans; Mice; Molecular Docking Simulation; Poly(ADP-ribose) Polymerase Inhibitors; Polymerization; Tubulin; Tubulin Modulators | 2022 |
Differential binding of methyl benzimidazol-2-yl carbamate to fungal tubulin as a mechanism of resistance to this antimitotic agent in mutant strains of Aspergillus nidulans.
Topics: Aspergillus nidulans; Benzimidazoles; Binding, Competitive; Carbamates; Colchicine; Drug Resistance; Glycoproteins; Griseofulvin; Hydrogen-Ion Concentration; Melatonin; Mutation; Podophyllotoxin; Receptors, Drug; Temperature; Tubulin; Vinblastine | 1977 |
Podophyllotoxin as a probe for the colchicine binding site of tubulin.
Topics: Animals; Binding Sites; Brain; Colchicine; Demecolcine; Glycoproteins; Hydrogen-Ion Concentration; Kinetics; Podophyllotoxin; Protein Binding; Rats; Spectrometry, Fluorescence; Tropolone; Tubulin | 1977 |
Studies on tissue culture produced plasminogen activator. I. Preliminary observations and the enhancing effect of colchicine and other antimitotic agents.
Topics: Animals; Cell Line; Colchicine; Culture Media; Hydrogen-Ion Concentration; Maytansine; Mitosis; Plasminogen Activators; Podophyllotoxin; Stimulation, Chemical; Swine; Vinblastine; Vincristine | 1977 |
Enhancement of macrophage adenylate cyclase by microtubule disrupting drugs.
Topics: Adenylyl Cyclases; Alprostadil; Animals; Calcimycin; Cells, Cultured; Colchicine; Cyclic AMP; Cytochalasin B; Deuterium Oxide; Guinea Pigs; Isoproterenol; Macrophages, Peritoneal; Male; Microtubules; Phosphodiesterase Inhibitors; Podophyllotoxin; Vinblastine | 1978 |
Inhibition of axoplasmic transport by colchicine, podophyllotoxin, and vinblastine: an effect on microtubules.
Topics: Animals; Axonal Transport; Binding, Competitive; Brain; Colchicine; Dose-Response Relationship, Drug; Microtubules; Models, Biological; Nerve Tissue Proteins; Podophyllotoxin; Protein Binding; Rats; Sciatic Nerve; Tubulin; Vinblastine | 1975 |
Microtubules and axoplasmic transport. Inhibition of transport by podophyllotoxin: an interaction with microtubule protein.
Topics: Animals; Axonal Transport; Colchicine; Dose-Response Relationship, Drug; Female; Glycoproteins; Microtubules; Podophyllin; Podophyllotoxin; Rats; Sciatic Nerve; Tubulin; Vinblastine | 1975 |
A correlation between the effects of anti-mitotic drugs on microtubule assembly in vitro and the inhibition of axonal transport in noradrenergic neurones.
Topics: Animals; Axonal Transport; Axons; Binding Sites; Biological Transport; Cats; Colchicine; Griseofulvin; Hypogastric Plexus; In Vitro Techniques; Microtubules; Norepinephrine; Podophyllotoxin; Tubulin | 1975 |
Comparative study of early effects of epipodophyllotoxin derivatives and other cytostatic agents on mastocytoma cultures.
Topics: Antineoplastic Agents; Bleomycin; Cell Division; Cell Line; Colchicine; Cytarabine; DNA, Neoplasm; Etoposide; Mast-Cell Sarcoma; Mechlorethamine; Mercaptopurine; Methotrexate; Mitosis; Neoplasm Proteins; Neoplasms, Experimental; Podophyllotoxin; Razoxane; RNA, Neoplasm; Teniposide; Vincristine; X-Rays | 1977 |
Further evidence for the involvement of microtubules in the proximo-distal intra-axonal transport of acetylcholine and related enzymes in rat sciatic nerve.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Axonal Transport; Axons; Choline O-Acetyltransferase; Colchicine; Male; Microtubules; Peripheral Nerves; Podophyllotoxin; Rats; Sciatic Nerve | 1978 |
Correlation of tubulin-binding and antitumor activities of podophyllotoxin analogs.
Topics: Animals; Antineoplastic Agents; Ciliophora; Colchicine; Culture Techniques; Glycoproteins; Mice; Neoplasms, Experimental; Podophyllotoxin; Protein Binding; Tubulin | 1978 |
Monolayer cultures of normal adult rat adrenocortical cells: steroidogenic responses to nucleotides, bacterial toxins and antimicrotubular agents.
Topics: Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Antineoplastic Agents, Phytogenic; Colchicine; Corticosterone; Culture Techniques; Cyclic AMP; Enterotoxins; Male; Nucleotides, Cyclic; Podophyllotoxin; Purines; Rats; Ribonucleosides; Vibrio cholerae; Vinblastine | 1976 |
Evidence for involvement of microtubules in the action of vasopressin in toad urinary bladder. I. Functional studies on the effects of antimitotic agents on the response to vasopressin.
Topics: Animals; Biological Transport; Bufo marinus; Colchicine; Cyclic AMP; In Vitro Techniques; Microtubules; Podophyllotoxin; Urinary Bladder; Vasopressins; Vinblastine; Water | 1978 |
Glucagon or cyclic AMP-stimulated synthesis of 5-phosphoribosyl 1-pyrophosphate in isolated hepatocytes and inhibition by antimicrotubular drugs.
Topics: Animals; Colchicine; Cyclic AMP; Cyclic GMP; Cytochalasin B; Epinephrine; Glucagon; In Vitro Techniques; Insulin; Liver; Male; Pentosephosphates; Phosphoribosyl Pyrophosphate; Podophyllotoxin; Rats; Vinblastine | 1978 |
Succinyl concanavalin A stimulates and antimicrotubular drugs inhibit the synthesis of a brain-specific protein in rat glial cells.
Topics: Cell Line; Colchicine; Concanavalin A; Demecolcine; Griseofulvin; Kinetics; Microtubules; Mitotic Index; Nerve Tissue Proteins; Neuroglia; Podophyllotoxin; S100 Proteins; Vinblastine | 1977 |
Growth cone formation in cultures of sensory neurons.
Topics: Axons; Cells, Cultured; Colchicine; Cycloheximide; Cytochalasin B; Demecolcine; Ganglia, Spinal; Nerve Tissue Proteins; Neurons; Podophyllotoxin; Puromycin | 1978 |
Intact microtubules are required for rapid turnover of carboxyl-terminal tyrosine of alpha-tubulin in cell cultures.
Topics: Animals; Cells, Cultured; Chick Embryo; Colchicine; Glycoproteins; Kinetics; Microtubules; Muscles; Podophyllotoxin; Pressure; Tubulin; Tyrosine; Vinblastine | 1979 |
Antitubulin agents enhance the stimulation of DNA synthesis by polypeptide growth factors in 3T3 mouse fibroblasts.
Topics: Animals; Cell Line; Colchicine; Demecolcine; DNA; Drug Synergism; Epidermal Growth Factor; Growth Substances; Insulin; Mice; Microtubules; Podophyllotoxin; Tubulin Modulators; Vinblastine | 1979 |
Cytoskeletal control of concanavalin A receptor mobility in peritoneal macrophages.
Topics: Colchicine; Concanavalin A; Cytochalasin B; Cytoplasm; Cytoskeleton; Macrophage Migration-Inhibitory Factors; Macrophages; Microtubules; Movement; Podophyllotoxin; Receptors, Concanavalin A; Receptors, Drug; Vinblastine | 1979 |
Microtubules inside the plasma membrane of squid giant axons and their possible physiological function.
Topics: Action Potentials; Animals; Axons; Calcium; Cell Membrane; Colchicine; Decapodiformes; Fluorides; Glutamates; Griseofulvin; Halogens; Lumicolchicines; Membrane Potentials; Microtubules; Podophyllotoxin; Sulfhydryl Reagents; Vinblastine | 1979 |
Polymerization of tubulin in the presence of colchicine or podophyllotoxin. Formation of a ribbon structure induced by guanylyl-5'-methylene diphosphonate.
Topics: Colchicine; Guanosine Triphosphate; Kinetics; Microtubules; Podophyllotoxin; Protein Binding; Tubulin | 1979 |
Microtubule proteins in axolotl eggs and developing embryos.
Topics: Age Factors; Albinism; Ambystoma; Animals; Binding, Competitive; Chemical Precipitation; Colchicine; Female; Glycoproteins; Kinetics; Molecular Weight; Oocytes; Oogenesis; Ovum; Podophyllotoxin; Protein Binding; Solubility; Temperature; Tubulin; Vinblastine | 1977 |
The interaction of colchicine and some related alkaloids with rat brain tubulin.
Topics: Alkaloids; Animals; Binding Sites; Binding, Competitive; Chemical Phenomena; Chemistry; Colchicine; Glycoproteins; Isomerism; Kinetics; Podophyllin; Podophyllotoxin; Protein Binding; Rats; Stereoisomerism; Time Factors; Tubulin | 1977 |
Antimitotic and antitubulin activity of the tumor inhibitor steganacin.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Binding, Competitive; Cell Division; Colchicine; Cycloparaffins; Female; Glycoproteins; Lactones; Lignans; Microtubules; Mitosis; Ovum; Podophyllotoxin; Sea Urchins; Tubulin; Tubulin Modulators; Ultracentrifugation | 1977 |
Quantitative analysis of tubulin and microtubule compartments in isolated rat hepatocytes.
Topics: Animals; Binding Sites; Cell Count; Colchicine; Cold Temperature; Glycoproteins; Liver; Microtubules; Podophyllotoxin; Rats; Tubulin; Vinblastine | 1977 |
Podophyllotoxin analogs. 1. Synthesis and biological evaluation of certain trans-2-aryl-trans-6-hydroxymethyl-3-cyclohexenecarboxylic acid gamma-lactones as antimitotic agents.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Brain; Cattle; Clone Cells; Colchicine; Cyclohexanecarboxylic Acids; Depression, Chemical; Hematopoiesis; In Vitro Techniques; Lactones; Mast-Cell Sarcoma; Mitosis; Podophyllotoxin; Protein Binding; Sarcoma, Experimental; Tubulin | 1976 |
Tubulin binding affinities of podophyllotoxin and colchicine analogues.
Topics: Animals; Binding, Competitive; Brain Chemistry; Chromatography, Ion Exchange; Colchicine; Depression, Chemical; Glycoproteins; In Vitro Techniques; Mice; Microscopy, Electron; Podophyllotoxin; Protein Binding; Structure-Activity Relationship; Tubulin | 1977 |
Properties of tubulin in unfertilized sea urchin eggs. Quantitation and characterization by the colchicine-binding reaction.
Topics: Animals; Binding, Competitive; Colchicine; Female; Glycoproteins; Kinetics; Ovum; Podophyllotoxin; Sea Urchins; Structure-Activity Relationship; Temperature; Tubulin; Vinblastine | 1976 |
Brain colchicine-binding protein (tubulin) during postnatal development in the rat.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Cerebellum; Cerebral Cortex; Colchicine; DNA; Glycoproteins; Podophyllotoxin; Polyethylene Glycols; Rats; Tubulin; Vinblastine | 1976 |
Inhibition by 4'-demethyl-epipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) of human lymphoblast cultures in G2 phase of the cell cycle.
Topics: Cell Count; Cell Division; Cell Line; Cell Survival; Colchicine; DNA, Neoplasm; Humans; Leukemia, Lymphoid; Mitosis; Podophyllotoxin; RNA, Neoplasm; Thymidine; Time Factors; Tritium; Uridine | 1975 |
Colchicine permeation is required for inhibition of concanavalin A capping in Chinese hamster ovary cells.
Topics: Binding Sites; Biological Transport; Cell Line; Cell Membrane; Colchicine; Concanavalin A; Dose-Response Relationship, Drug; Microtubules; Podophyllotoxin; Receptors, Drug | 1975 |
Tubulin aggregation and disaggregation: mediation by two distinct vinblastine-binding sites.
Topics: Animals; Binding Sites; Brain; Colchicine; Glycoproteins; Kinetics; Osmolar Concentration; Podophyllotoxin; Rats; Temperature; Tubulin; Vinblastine | 1976 |
Membrane-bound tubulin in brain and thyroid tissue.
Topics: Adenylyl Cyclases; Animals; Binding Sites; Binding, Competitive; Brain; Cattle; Cell Membrane; Colchicine; Detergents; Female; Glycoproteins; Kinetics; Podophyllotoxin; Protein Binding; Radioimmunoassay; Rats; Receptors, Drug; Subcellular Fractions; Temperature; Thyroid Gland; Tubulin; Vinblastine | 1975 |
Quantitative turbidimetric assay for potency evaluation of colchicine-like drugs.
Topics: Animals; Carbamates; Colchicine; Dose-Response Relationship, Drug; Glycoproteins; Griseofulvin; Melatonin; Microtubules; Nephelometry and Turbidimetry; Podophyllotoxin; Rats; Rotenone; Tubulin; Vinblastine; Vincristine | 1975 |
Drugs that disrupt microtubuli do not inhibit lymphocyte activation.
Topics: Animals; Colchicine; DNA; Lymphocyte Activation; Microtubules; Podophyllotoxin; Rats; RNA; Time Factors; Vinblastine | 1976 |
Microtubule assembly protects the region 28-38 of the beta-tubulin subunit.
Topics: Amino Acid Sequence; Antibodies; Binding Sites, Antibody; Binding, Competitive; Cell Line; Colchicine; Microtubules; Molecular Sequence Data; Peptides; Podophyllotoxin; Protein Conformation; Tubulin | 1992 |
Synthesis and evaluation of 2-diazo-3,3,3-trifluopropanoyl derivatives of colchicine and podophyllotoxin as photoaffinity labels: reactivity, photochemistry, and tubulin binding.
Topics: Affinity Labels; Binding Sites; Colchicine; Diazonium Compounds; Indicators and Reagents; Kinetics; Photochemistry; Podophyllotoxin; Structure-Activity Relationship; Tubulin | 1992 |
The affinity of DNA-microtubule protein complexes and their disruption by tubulin binding drugs.
Topics: Animals; Cattle; Centromere; Colchicine; DNA-Binding Proteins; DNA, Fungal; DNA, Satellite; Microtubule Proteins; Microtubule-Associated Proteins; Podophyllotoxin; Saccharomyces cerevisiae; Vinblastine | 1992 |
Direct photoaffinity labeling of tubulin with colchicine.
Topics: Affinity Labels; Animals; Binding Sites; Brain; Colchicine; Kinetics; Light; Podophyllotoxin; Protein Binding; Rats; Tubulin; Vinblastine | 1991 |
Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria.
Topics: Animals; Antineoplastic Agents; Cell Line; Chick Embryo; Colchicine; Fluorescent Antibody Technique; Guinea Pigs; Microtubules; Mitochondria; Mutation; Nocodazole; Podophyllotoxin; Vinblastine | 1990 |
Interaction of rhizoxin with bovine brain tubulin.
Topics: Animals; Antibiotics, Antineoplastic; Brain; Cattle; Colchicine; Cross-Linking Reagents; Ethylenediamines; Kinetics; Lactones; Macrolides; Maytansine; Molecular Structure; Mycotoxins; Podophyllotoxin; Tubulin; Vinblastine | 1990 |
Breakthrough in microtubule research.
Topics: Colchicine; Griseofulvin; Humans; Microtubules; Podophyllotoxin; Vinca Alkaloids | 1989 |
Colchicine binding in the free-living nematode Caenorhabditis elegans.
Topics: Animals; Binding Sites; Brain; Caenorhabditis; Colchicine; Kinetics; Mebendazole; Podophyllotoxin; Sheep; Tubulin; Vinblastine | 1989 |
Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin.
Topics: Animals; Bibenzyls; Binding Sites; Brain; Cattle; Colchicine; Guanosine Triphosphate; Kinetics; Macromolecular Substances; Mitosis; Models, Structural; Plant Extracts; Podophyllotoxin; Protein Binding; Stilbenes; Tropolone; Tubulin | 1989 |
Cross-resistance of novobiocin-resistant BHK cell line to topoisomerase II inhibitors.
Topics: Amsacrine; Animals; Cell Line; Colchicine; Cytarabine; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Novobiocin; Podophyllotoxin; Vinblastine | 1988 |
Involvement of microtubules in lipoprotein degradation and utilization for steroidogenesis in cultured rat luteal cells.
Topics: Alkaloids; Animals; Benzimidazoles; Cells, Cultured; Colchicine; Corpus Luteum; Deuterium; Dimethyl Sulfoxide; Female; Humans; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lumicolchicines; Microtubules; Nocodazole; Paclitaxel; Podophyllotoxin; Progesterone; Rats; Time Factors; Vinblastine | 1985 |
Analysis of drug-tubulin interaction by trypsin cleavage: comparison for colchicine, podophyllotoxin, griseofulvin, vinblastine and taxol.
Topics: Alkaloids; Animals; Brain; Colchicine; Griseofulvin; Paclitaxel; Podophyllotoxin; Protein Binding; Swine; Trypsin; Tubulin; Vinblastine | 1986 |
Effects of microtubule inhibitors on etoposide accumulation and DNA damage in human K562 cells in vitro.
Topics: Alkaloids; Cell Line; Colchicine; DNA; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Humans; In Vitro Techniques; Maytansine; Microtubules; Paclitaxel; Podophyllotoxin; Time Factors; Vinblastine | 1987 |
Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Chromosome Banding; Chromosomes, Human, Pair 13; Colchicine; Dactinomycin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Leukemia; Membrane Glycoproteins; Molecular Weight; Podophyllotoxin; Teniposide; Tumor Cells, Cultured; Verapamil; Vinblastine; Vinca Alkaloids | 1987 |
Increased spindle resistance to antimicrotubule agents in women of high risk for meiotic nondisjunction.
Topics: Adult; Age Factors; Colchicine; Down Syndrome; Female; Humans; In Vitro Techniques; Lymphocytes; Meiosis; Microtubules; Middle Aged; Nondisjunction, Genetic; Podophyllotoxin; Risk; Spindle Apparatus; Vinblastine | 1986 |
Transferrin endocytosis and iron uptake in developing myogenic cells in culture: effects of microtubular and metabolic inhibitors, sulphydryl reagents and lysosomotrophic agents.
Topics: 2,4-Dinitrophenol; Ammonium Chloride; Animals; Antimycin A; Azides; Cells, Cultured; Chick Embryo; Chloroquine; Colchicine; Dinitrophenols; Endocytosis; Iron; Methylamines; Muscles; Podophyllotoxin; Sodium Azide; Sulfhydryl Reagents; Transferrin; Vinblastine | 1988 |
Methylenedioxy-benzopyran analogs of podophyllotoxin, a new synthetic class of antimitotic agents that inhibit tubulin polymerization.
Topics: Animals; Antineoplastic Agents; Benzopyrans; Binding, Competitive; Cattle; Colchicine; Guanosine Triphosphate; In Vitro Techniques; Microtubules; Mitosis; Podophyllotoxin; Structure-Activity Relationship; Tubulin | 1988 |
Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.
Topics: Animals; Anisoles; Antineoplastic Agents; Bibenzyls; Binding Sites; Binding, Competitive; Colchicine; Leukemia L1210; Mice; Mitosis; Podophyllotoxin; Protein Binding; Stilbenes; Structure-Activity Relationship; Tubulin | 1988 |
Phorbol diesters and transferrin modulate lymphoblastoid cell transferrin receptor expression by two different mechanisms.
Topics: Cell Line; Colchicine; Cold Temperature; Cytochalasin B; Cytoskeleton; Drug Interactions; Kinetics; Phorbol Esters; Podophyllotoxin; Receptors, Transferrin; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transferrin; Vinblastine | 1986 |
Interaction of tubulin with the macromolecular apolar probe, octyl sepharose.
Topics: Anilino Naphthalenesulfonates; Colchicine; Podophyllotoxin; Sepharose; Tubulin; Vinblastine | 1987 |
The role of the B-ring of colchicine in the stability of the colchicine-tubulin complex.
Topics: Colchicine; Kinetics; Molecular Conformation; Podophyllotoxin; Protein Binding; Structure-Activity Relationship; Temperature; Tubulin | 1987 |
Morpholino derivatives of benzyl-benzodioxole, a study of structural requirements for drug interactions at the colchicine/podophyllotoxin binding site of tubulin.
Topics: Benzyl Compounds; Binding Sites; Colchicine; Dioxoles; Guanosine Triphosphate; Morpholines; Podophyllotoxin; Polymers; Structure-Activity Relationship; Tubulin | 1986 |
Species-specific differences in toxicity of antimitotic agents toward cultured mammalian cells.
Topics: 4-Butyrolactone; Animals; Benzimidazoles; Biological Transport; Cells, Cultured; Colchicine; Cricetinae; Cricetulus; Griseofulvin; HeLa Cells; Humans; Lignans; Maytansine; Mice; Mitosis; Nocodazole; Podophyllotoxin; Species Specificity; Vinblastine | 1985 |
The effects of colchicine analogues on the reaction of tubulin with iodo[14C]acetamide and N,N'-ethylenebis(iodoacetamide).
Topics: Alkylation; Animals; Benzaldehydes; Benzimidazoles; Colchicine; Ethylenediamines; Iodoacetamide; Iodoacetates; Mathematics; Nocodazole; Podophyllotoxin; Rabbits; Tropolone; Tubulin | 1985 |
Interaction of reduced glutathione with bovine brain tubulin.
Topics: Animals; Brain Chemistry; Cattle; Colchicine; Glutathione; Glutathione Disulfide; Maytansine; Microscopy, Electron; Osmolar Concentration; Podophyllotoxin; Polymers; Temperature; Tubulin | 1985 |
Comparative neurotoxicity of tubulin-binding drugs: inhibition of goldfish optic nerve regeneration.
Topics: Analysis of Variance; Animals; Axons; Colchicine; Goldfish; Injections, Intraperitoneal; Nerve Regeneration; Optic Nerve; Podophyllotoxin; Vinblastine; Vincristine | 1985 |
N,N'-Ethylene-bis(iodoacetamide) as a probe for structural and functional characteristics of brine shrimp, squid, and bovine tubulins.
Topics: Alkylation; Animals; Artemia; Benzimidazoles; Cattle; Cell Fractionation; Colchicine; Cross-Linking Reagents; Decapodiformes; Ethylenediamines; Maytansine; Microtubules; Molecular Weight; Nocodazole; Podophyllotoxin; Species Specificity; Tubulin; Vinblastine | 1985 |
Microtubules and axoplasmic transport.
Topics: Animals; Axonal Transport; Carbamates; Colchicine; Dose-Response Relationship, Drug; Microtubules; Nerve Tissue Proteins; Optic Nerve; Podophyllotoxin; Proline; Rats; Tritium; Vinblastine | 1974 |
Segregation during ascidian embryogenesis of egg cytoplasmic information for tissue-specific enzyme development.
Topics: Acetylcholinesterase; Animals; Catechol Oxidase; Cell Division; Colchicine; Cytochalasin B; Cytoplasm; Dactinomycin; Female; Histocytochemistry; Monophenol Monooxygenase; Ovum; Podophyllotoxin; Puromycin; RNA; Urochordata | 1973 |
Stimulation of steroid secretion by antimicrotubular agents.
Topics: Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Cell Line; Chromatography, Thin Layer; Colchicine; Cyclic AMP; Deuterium; Hydroxysteroids; Ketosteroids; Leydig Cell Tumor; Mice; Microtubules; Mitosis; Podophyllotoxin; Pregnenes; Pregnenolone; Protein Biosynthesis; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Stimulation, Chemical; Time Factors; Vinblastine | 1973 |
Vasopressin: possible role of microtubules and microfilaments in its action.
Topics: Animals; Biological Transport; Bufo marinus; Colchicine; Cyclic AMP; Cytochalasin B; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; In Vitro Techniques; Microscopy, Electron; Microtubules; Organoids; Osmosis; Podophyllotoxin; Sodium; Urinary Bladder; Vasopressins; Vinblastine; Water | 1973 |
Microtubule assembly and function in Chlamydomonas: inhibition of growth and flagellar regeneration by antitubulins and other drugs and isolation of resistant mutants.
Topics: Alkanesulfonates; Chlamydomonas; Colchicine; Deoxycholic Acid; Drug Resistance, Microbial; Flagella; Microtubules; Mitosis; Mutagens; Mutation; Nitrosoguanidines; Podophyllotoxin; Protein Binding; Regeneration; Time Factors; Vinblastine | 1974 |
Effects of x-radiation on growth and function of the repair blastema (granulation tissue). III. Measurements of pharmacodynamic activity in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Amino Acids; Angiotensin II; Animals; Bradykinin; Colchicine; Cytochalasin B; Dinitrophenols; Dose-Response Relationship, Drug; Epinephrine; Female; Granulation Tissue; Griseofulvin; Histamine; In Vitro Techniques; Isoproterenol; Norepinephrine; Papaverine; Pilocarpine; Podophyllotoxin; Prostaglandins; Radiation Effects; Rats; Serotonin; Vasopressins; Vinblastine; Vincristine; X-Rays | 1974 |
Biochemical and pharmacological comparison of microtubule protein from human and chick brain.
Topics: Animals; Binding Sites; Brain; Chick Embryo; Child, Preschool; Chromatography, Gel; Colchicine; Depression, Chemical; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Infant; Male; Microtubules; Middle Aged; Molecular Weight; Nerve Tissue Proteins; Podophyllotoxin; Stimulation, Chemical; Tritium; Vinblastine | 1974 |
Promotion of fluorescence upon binding of colchicine to tubulin.
Topics: Animals; Binding Sites; Brain; Colchicine; Guanidines; Microtubules; Molecular Weight; Nerve Tissue Proteins; Podophyllotoxin; Protein Conformation; Protein Denaturation; Rats; Sodium Dodecyl Sulfate; Spectrometry, Fluorescence; Temperature; Tritium; Urea; Vinblastine | 1974 |
Modulation of lymphocyte receptor redistribution by concanavalin A, anti-mitotic agents and alterations of pH.
Topics: Alkaloids; Animals; Antibodies, Anti-Idiotypic; Antigen-Antibody Reactions; Binding Sites, Antibody; Colchicine; Concanavalin A; Griseofulvin; Hydrogen-Ion Concentration; Lymphocytes; Mice; Podophyllotoxin; Strychnine; Vinblastine; Vincristine | 1973 |
Interaction of some colchicine analogs, vinblastine and podophyllotoxin with rat brain microtubule protein.
Topics: Animals; Brain; Colchicine; In Vitro Techniques; Male; Molecular Weight; Podophyllotoxin; Protein Binding; Proteins; Rats; Temperature; Time Factors; Tritium; Vinblastine | 1973 |
The mechanism of action of colchicine. Colchicine binding properties of sea urchin sperm tail outer doublet tubulin.
Topics: Animals; Binding Sites; Binding, Competitive; Colchicine; Male; Microscopy, Electron; Microtubules; Podophyllotoxin; Protein Binding; Proteins; Sea Urchins; Solubility; Spermatozoa; Temperature; Time Factors; Tritium; Vinblastine; Vinca Alkaloids; Vincristine | 1973 |
Interaction of drugs with microtubule proteins.
Topics: Animals; Binding Sites; Brain; Chick Embryo; Colchicine; Griseofulvin; In Vitro Techniques; Kinetics; Male; Microtubules; Mitosis; Podophyllotoxin; Protein Binding; Proteins; Receptors, Drug; Sea Urchins; Spermatozoa; Tritium; Vinca Alkaloids | 1974 |
Effects of antimicrotubular agents in cAMP production and in steroidogenic response of isolated rat Leydig cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Cell Membrane; Colchicine; Cyclic AMP; Dose-Response Relationship, Drug; Leydig Cells; Luteinizing Hormone; Male; Microtubules; Podophyllotoxin; Rats; Secretory Rate; Testosterone; Vinblastine | 1984 |
Evidence that microtubule depolymerization early in the cell cycle is sufficient to initiate DNA synthesis.
Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cells, Cultured; Colchicine; DNA Replication; Growth Substances; Microtubules; Paclitaxel; Podophyllotoxin; Terpenes; Thrombin; Vinblastine | 1981 |
Effects of inhibitors of tubulin polymerization on GTP hydrolysis.
Topics: Animals; Benzimidazoles; Brain; Carbamates; Cattle; Colchicine; GTP Phosphohydrolases; Kinetics; Macromolecular Substances; Maytansine; Nocodazole; Oxazines; Phosphoric Monoester Hydrolases; Podophyllotoxin; Solvents; Structure-Activity Relationship; Tubulin; Vinblastine | 1981 |
Calmodulin, activated cyclic nucleotide phosphodiesterase, microtubules, and vinca alkaloids.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Calcium; Calcium-Binding Proteins; Calmodulin; Cattle; Colchicine; Cyclic Nucleotide Phosphodiesterases, Type 1; Griseofulvin; Microtubules; Phenoxybenzamine; Podophyllotoxin; Rats; Vinca Alkaloids | 1982 |
Stimulation of tubulin-dependent ATPase activity in microtubule proteins from porcine brain by taxol.
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Brain; Ca(2+) Mg(2+)-ATPase; Calcium; Colchicine; Microtubule-Associated Proteins; Paclitaxel; Podophyllotoxin; Proteins; Swine; Tubulin; Vinblastine | 1983 |
Vinblastine inhibits the maturation of the precursor of mitochondrial aspartate aminotransferase. Vincristine and six other cytoskeleton inhibitors do not show this effect.
Topics: Alkaloids; Animals; Aspartate Aminotransferases; Benzimidazoles; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Chick Embryo; Colchicine; Cytochalasin D; Cytochalasins; Enzyme Precursors; Fibroblasts; Kinetics; Mitochondria; Nocodazole; Oxygen Consumption; Paclitaxel; Phalloidine; Podophyllotoxin; Vinblastine | 1983 |
Axonal microtubules necessary for generation of sodium current in squid giant axons: I. Pharmacological study on sodium current and restoration of sodium current by microtubule proteins and 260K protein.
Topics: Alkaloids; Animals; Axons; Colchicine; Decapodiformes; Deuterium; Deuterium Oxide; Dimethyl Sulfoxide; Dithionitrobenzoic Acid; Ethylmaleimide; Microtubules; Paclitaxel; Podophyllotoxin; Sodium; Temperature; Tubulin; Vinblastine; Water | 1984 |
Effects of mitosis inhibitors on respiration and fast axonal transport in frog sciatic nerves.
Topics: Animals; Axonal Transport; Carbon Dioxide; Colchicine; Glucose; In Vitro Techniques; Mitosis; Oxygen Consumption; Podophyllotoxin; Rana temporaria; Sciatic Nerve; Vinblastine | 1981 |
Long-term memory: disruption by inhibitors of protein synthesis and cytoplasmic flow.
Topics: Animals; Avoidance Learning; Axonal Transport; Colchicine; Drug Interactions; Male; Memory; Mice; Podophyllotoxin; Protein Biosynthesis; Vinblastine | 1981 |
Factors which disorganize microtubules or microfilaments increase the frequency of cell transformation by polyoma virus.
Topics: Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Colchicine; Cytochalasin B; Epidermal Growth Factor; Griseofulvin; Melitten; Mutagens; Podophyllotoxin; Polyomavirus; Tetradecanoylphorbol Acetate; Vinblastine | 1980 |
Different effects of tubulin ligands on the intrachain cross-linking of beta 1-tubulin.
Topics: Animals; Benzimidazoles; Brain Chemistry; Cattle; Colchicine; Cross-Linking Reagents; Ethylenediamines; Female; Guanosine Triphosphate; Ligands; Magnesium; Magnesium Chloride; Maytansine; Nocodazole; Podophyllotoxin; Tubulin; Vinblastine | 1984 |
Binding of colchicine to beef brain tubulin: influence of methodology on binding constants.
Topics: Animals; Brain; Cattle; Chromatography, DEAE-Cellulose; Colchicine; In Vitro Techniques; Kinetics; Podophyllotoxin; Protein Binding; Tubulin | 1984 |
Immunological detection of microtubule poison-induced conformational changes in tubulin.
Topics: Animals; Antigen-Antibody Complex; Brain; Chick Embryo; Colchicine; Immune Sera; Kinetics; Microtubules; Podophyllotoxin; Radioimmunoassay; Tubulin; Vinblastine | 1983 |
Microtubule-depolymerizing agents inhibit asialo-orosomucoid delivery to lysosomes but not its endocytosis or degradation in isolated rat hepatocytes.
Topics: Animals; Asialoglycoproteins; Colchicine; Endocytosis; Kinetics; Liver; Lysosomes; Microtubules; Orosomucoid; Podophyllotoxin; Rats; Vinblastine | 1983 |
Reduced effect of microtubule inhibitors on hepatic protein secretion in the fetal rat.
Topics: Albumins; Animals; Colchicine; Female; Liver; Male; Microtubules; Podophyllotoxin; Proteins; Rats; Trichloroacetic Acid; Vinblastine | 1984 |
Mutants of chinese hamster ovary cells affected in two different microtubule-associated proteins. Genetic and biochemical studies.
Topics: Animals; Cell Line; Cell Survival; Colchicine; Cricetinae; Cricetulus; Drug Resistance; Female; Genes; Kinetics; Microtubule-Associated Proteins; Mutation; Nerve Tissue Proteins; Ovary; Podophyllotoxin; Proteins | 1984 |
Axonal microtubules necessary for generation of sodium current in squid giant axons: II. Effect of colchicine upon asymmetrical displacement current.
Topics: Animals; Axons; Colchicine; Decapodiformes; Microtubules; Podophyllotoxin; Sodium; Vinblastine | 1984 |
Interactions of the tau-tubulin-vinblastine complex with colchicine, podophyllotoxin, and N,N'-ethylenebis(iodoacetamide).
Topics: Animals; Brain; Cattle; Colchicine; Dimethyl Sulfoxide; Ethylenediamines; Iodoacetamide; Iodoacetates; Kinetics; Macromolecular Substances; Microtubules; Nerve Tissue Proteins; Podophyllotoxin; Proteins; tau Proteins; Tubulin; Vinblastine | 1982 |
Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross-resistance studies with various microtubule inhibitors and podophyllotoxin analogues.
Topics: Animals; Benzimidazoles; Cell Line; Cell Survival; Colchicine; Cricetinae; Cricetulus; Drug Resistance; Female; Microtubules; Mutation; Nocodazole; Ovary; Podophyllotoxin; Structure-Activity Relationship; Vinblastine | 1983 |
Differential radiolabeling of opposite microtubule ends: methodology, equilibrium exchange-flux analysis, and drug poisoning.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Colchicine; Isotope Labeling; Microtubules; Models, Chemical; Podophyllotoxin; Tubulin | 1983 |
Repair of a calcium-dependent adhesive mechanism of embryonic neural retina cells: kinetic and molecular analysis.
Topics: Animals; Calcium; Cell Adhesion; Cell Aggregation; Chick Embryo; Colchicine; Cycloheximide; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Kinetics; Monensin; Podophyllotoxin; Retina; Time Factors; Trypsin; Tunicamycin | 1983 |
Structural and functional diversity in the neuronal microtubules of Caenorhabditis elegans.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Caenorhabditis; Carbamates; Cilia; Colchicine; Microscopy, Electron; Microtubules; Neurons; Nocodazole; Podophyllotoxin; Temperature; Vinblastine | 1982 |
In vitro vinblastine-induced tubulin paracrystals.
Topics: Animals; Brain Chemistry; Cattle; Colchicine; Crystallization; Kinetics; Podophyllotoxin; Structure-Activity Relationship; Tubulin; Vinblastine | 1982 |
Conformational states of tubulin liganded to colchicine, tropolone methyl ether, and podophyllotoxin.
Topics: Animals; Brain Chemistry; Cattle; Circular Dichroism; Colchicine; Cycloheptanes; Mathematics; Podophyllotoxin; Protein Conformation; Tropolone; Tubulin | 1982 |
Tumor-promoting phorbol esters stimulate C3b and C3b' receptor-mediated phagocytosis in cultured human monocytes.
Topics: Cations; Cells, Cultured; Colchicine; Complement C3b; Cycloheximide; Erythrocytes; Humans; Monocytes; Phagocytosis; Phorbol Esters; Phorbols; Podophyllotoxin; Receptors, Complement; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Influence of cytoskeletal assembly on phosphatidylcholine synthesis in intact phagocytic cells.
Topics: Animals; Choline; Colchicine; Cytochalasin B; Cytoskeleton; Guinea Pigs; Lymphocytes; Macrophages; Male; Microtubules; Neutrophils; Phosphatidylcholines; Podophyllotoxin; Vinblastine; Vincristine | 1980 |
Effect of microtubule-disrupting drugs on protein and RNA synthesis in Physarum polycephalum amoebae.
Topics: Centrioles; Colchicine; Cytochalasin B; Cytoskeleton; Fungal Proteins; Griseofulvin; Microtubules; Podophyllotoxin; RNA, Fungal; Temperature; Vinblastine | 1980 |
Resistance to the microtubule inhibitor podophyllotoxin: selection and partial characterization of mutants in CHO cells.
Topics: Animals; Cell Line; Colchicine; Cricetinae; Cricetulus; Demecolcine; Dose-Response Relationship, Drug; Drug Resistance; Ethyl Methanesulfonate; Female; Griseofulvin; Microtubules; Mutation; Ovary; Podophyllotoxin; Vinblastine | 1981 |
Colchicine binding in the rat tapeworm, Hymenolepis diminuta.
Topics: Animals; Binding Sites; Colchicine; Half-Life; Hymenolepis; Lumicolchicines; Molecular Weight; Podophyllotoxin; Rats; Sodium Chloride; Tubulin; Vinblastine | 1981 |
Toxicity of microtubular drugs to leukemic lymphocytes.
Topics: Benzimidazoles; Carbamates; Colchicine; Humans; Leukemia, Lymphoid; Lymphocytes; Maytansine; Microtubules; Nocodazole; Podophyllotoxin; Tropolone; Vinblastine; Vincristine | 1981 |
Interaction of tubulin with drugs and alkylating agents. 2. Effects of colchicine, podophyllotoxin, and vinblastine on the alkylation of tubulin.
Topics: Alkylating Agents; Animals; Brain; Carbon Radioisotopes; Cattle; Colchicine; Cross-Linking Reagents; Ethylenediamines; Iodoacetamide; Iodoacetates; Kinetics; Podophyllotoxin; Tubulin; Vinblastine | 1981 |
Colchicine binding activity in the rat pancreas cytosol.
Topics: Animals; Colchicine; Cytosol; Guanosine Triphosphate; Kinetics; Pancreas; Podophyllotoxin; Rats; Vinca Alkaloids | 1980 |
Phorbol myristate acetate stimulates pinocytosis and membrane spreading in mouse peritoneal macrophages.
Topics: Animals; Ascitic Fluid; Cell Movement; Colchicine; Cytochalasins; Endocytosis; Horseradish Peroxidase; Macrophages; Mice; Phorbols; Pinocytosis; Podophyllotoxin; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1980 |
Isolation and partial characterization of flagellar tubulin from Marsilea vestita.
Topics: Animals; Colchicine; Electrophoresis, Polyacrylamide Gel; Flagella; Mitosis; Plants; Podophyllotoxin; Species Specificity; Tubulin; Vinblastine | 1980 |
[Characterization of the mechanism of cross-resistance to vinca alkaloids and taxoids in the human J82 bladder tumor cell line].
Topics: Antineoplastic Agents; Carcinoma; Colchicine; Doxorubicin; Drug Resistance, Multiple; Gene Expression Regulation, Neoplastic; Humans; Paclitaxel; Phenotype; Podophyllotoxin; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Vinblastine; Vinorelbine | 1994 |
Induction of aneuploidy in Chinese hamster oocytes following in vivo treatments with trimethoxybenzoic compounds and their analogues.
Topics: Aneuploidy; Animals; Colchicine; Cricetinae; Cricetulus; Female; Gallic Acid; Oocytes; Podophyllotoxin; Reserpine; Spindle Apparatus; Tubulin; Vinblastine | 1995 |
Antimicrotubule properties of benzophenanthridine alkaloids.
Topics: Alkaloids; Animals; Benzophenanthridines; Berberine Alkaloids; Colchicine; Isoquinolines; Microtubules; Paclitaxel; Phenanthridines; Podophyllotoxin; Protein Binding; Rats; Spectrometry, Fluorescence; Tetrahydroisoquinolines; Tubulin | 1993 |
Removal of beta III isotype enhances taxol induced microtubule assembly.
Topics: Animals; Brain; Cattle; Colchicine; Cold Temperature; In Vitro Techniques; Microscopy, Electron; Microtubules; Paclitaxel; Podophyllotoxin; Tubulin | 1993 |
Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin.
Topics: Alkylation; Animals; Binding Sites; Brain Chemistry; Cattle; Colchicine; Cross-Linking Reagents; Drug Interactions; Ethers, Cyclic; Ethylenediamines; Macrolides; Magnesium Chloride; Microtubules; Molecular Conformation; Podophyllotoxin; Structure-Activity Relationship; Tubulin; Vinblastine | 1993 |
Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin.
Topics: Animals; Antineoplastic Agents; Binding, Competitive; Brain; Cattle; Cell Division; Colchicine; Growth Inhibitors; Leukemia, Experimental; Mice; Podophyllotoxin; Protein Binding; Quinazolines; Structure-Activity Relationship; Styrenes; Tubulin; Vinblastine | 1996 |
Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin polymers.
Topics: 2-Methoxyestradiol; Binding Sites; Colchicine; Estradiol; Glutamates; Kinetics; Microtubule-Associated Proteins; Microtubules; Podophyllotoxin; Polymers; Stilbenes; Tubulin | 1996 |
Evaluation of the cytotoxic mechanism mediated by baccatin III, the synthetic precursor of taxol.
Topics: Alkaloids; Animals; Antineoplastic Agents; Binding Sites; Cell Cycle; Colchicine; Humans; Mice; Microtubules; Paclitaxel; Podophyllotoxin; Polymers; Protein Binding; Taxoids; Tubulin; Tumor Cells, Cultured; Vinblastine | 1996 |
Studies to show that with podophyllotoxin the early replicative stages of herpes simplex virus type 1 depend upon functional cytoplasmic microtubules.
Topics: Animals; Antimetabolites; Antiviral Agents; Chlorocebus aethiops; Colchicine; Deoxyuridine; Herpes Simplex; Microtubules; Podophyllotoxin; Simplexvirus; Vero Cells; Virus Replication | 1996 |
Involvement of microtubules in prothoracicotropic hormone-stimulated ecdysteroidogenesis by insect (Manduca sexta) prothoracic glands.
Topics: Actin Cytoskeleton; Animals; Colchicine; Cytochalasin B; Cytochalasin D; Ecdysteroids; Endocrine Glands; In Vitro Techniques; Insect Hormones; Manduca; Microtubules; Nocodazole; Podophyllotoxin; Steroids | 1996 |
Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents.
Topics: Antineoplastic Agents, Phytogenic; Bibenzyls; Binding Sites; Colchicine; Models, Molecular; Paclitaxel; Podophyllotoxin; Protein Conformation; Software; Stilbenes; Tubulin; Tubulin Modulators | 1996 |
Alterations of rings B and C of colchicine are cumulative in overall binding to tubulin but modify each kinetic step.
Topics: Biphenyl Compounds; Colchicine; Dimerization; Fluorescence; Kinetics; Models, Chemical; Molecular Structure; Podophyllotoxin; Protein Binding; Thermodynamics; Tropolone; Tubulin | 1996 |
Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Benzoquinones; Binding Sites; Colchicine; Demecolcine; Enzyme Inhibitors; Gout Suppressants; Humans; Lactams, Macrocyclic; Microtubules; Mutagenesis, Site-Directed; Paclitaxel; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-raf; Quinones; Serine; Tumor Cells, Cultured | 1998 |
Use of drugs to study role of microtubule assembly dynamics in living cells.
Topics: Alkaloids; Antineoplastic Agents; Biopolymers; Cell Line; Colchicine; Drug Synergism; Microtubules; Molecular Weight; Nocodazole; Paclitaxel; Podophyllotoxin; Tubulin; Vinblastine | 1998 |
Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay.
Topics: Alkylation; Animals; Antineoplastic Agents; Binding Sites; Cattle; Colchicine; Iodoacetamide; Nocodazole; Podophyllotoxin; Pyridones; Spectrometry, Fluorescence; Structure-Activity Relationship; Tubulin | 1998 |
Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Colchicine; Egtazic Acid; Enzyme Activation; Humans; Microtubules; Nocodazole; Paclitaxel; Podophyllotoxin; Tumor Cells, Cultured; Vincristine | 1999 |
Rapid colchicine competition-binding scintillation proximity assay using biotin-labeled tubulin.
Topics: Aminophenols; Bibenzyls; Binding Sites; Binding, Competitive; Biotinylation; Colchicine; Demecolcine; Mebendazole; Microspheres; Podophyllotoxin; Scintillation Counting; Solvents; Stilbenes; Streptavidin; Sulfonamides; Tritium; Tubulin; Yttrium | 2000 |
The interaction of the B-ring of colchicine with alpha-tubulin: a novel footprinting approach.
Topics: Amino Acid Sequence; Animals; Bibenzyls; Binding Sites; Cattle; Chromatography, High Pressure Liquid; Colchicine; Fluorescence; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Podophyllotoxin; Protein Conformation; Protein Footprinting; Stilbenes; Tropolone; Tryptophan; Tubulin; Urea | 2000 |
Meiotic telomere clustering is inhibited by colchicine but does not require cytoplasmic microtubules.
Topics: Cells, Cultured; Chromosome Segregation; Colchicine; Cytoplasm; Dose-Response Relationship, Drug; Flowers; Meiosis; Microtubules; Molecular Structure; Podophyllotoxin; Polymers; Prophase; Secale; Telomere | 2002 |
[Effect of urethane, demecolcine and podophyllotoxin on experimental inflammation].
Topics: Colchicine; Demecolcine; Inflammation; Podophyllin; Podophyllotoxin; Podophyllum; Urethane | 1958 |
[Comparative anticellular action of colchicine and podophyllotoxin. Experimental research].
Topics: Cell Division; Colchicine; Humans; Podophyllin; Podophyllotoxin; Podophyllum | 1959 |
[The influence of ethyl urethane, demecolcine and podophyllotoxin on experimental inflammation in rats].
Topics: Animals; Colchicine; Demecolcine; Inflammation; Podophyllin; Podophyllotoxin; Podophyllum; Rats; Urethane | 1960 |
The effect of podophyllotoxin, colchicine, urethane, and nitrogen mustard on the respiration of normal and suprarenalectomized rat lymphatic tissue.
Topics: Animals; Colchicine; Lymphoid Tissue; Mechlorethamine; Nitrogen Mustard Compounds; Podophyllotoxin; Podophyllum; Rats; Tissues; Urethane | 1950 |
A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.
Topics: 2-Methoxyestradiol; 4-Butyrolactone; Aminophenols; Binding Sites; Chalcone; Colchicine; Cyclopropanes; Estradiol; Indans; Lignans; Models, Molecular; Molecular Structure; Nocodazole; Podophyllotoxin; Protein Binding; Stilbenes; Structure-Activity Relationship; Sulfonamides; Thiazoles; Tubulin; Tubulin Modulators | 2005 |
Thiocolchicine-podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction.
Topics: Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Colchicine; Combinatorial Chemistry Techniques; Disulfides; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Molecular Conformation; Podophyllotoxin; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2006 |
Oxalone and lactone moieties of podophyllotoxin exhibit properties of both the B and C rings of colchicine in its binding with tubulin.
Topics: Animals; Colchicine; Crystallography, X-Ray; Goats; Lactones; Podophyllotoxin; Protein Binding; Thermodynamics; Tubulin | 2006 |
Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin.
Topics: Cell Line; Cell Line, Tumor; Cell Proliferation; Chalcone; Colchicine; Drug Screening Assays, Antitumor; Epithelial Cells; Humans; Models, Molecular; Podophyllotoxin; Protein Binding; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2006 |
Insight into the GTPase activity of tubulin from complexes with stathmin-like domains.
Topics: Animals; Cattle; Colchicine; GTP Phosphohydrolases; Ligands; Podophyllotoxin; Protein Structure, Secondary; Protein Structure, Tertiary; Stathmin; Tubulin; Vinblastine | 2007 |
Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III.
Topics: Alkaloids; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Colchicine; Combinatorial Chemistry Techniques; Dimerization; Drug Design; Humans; Podophyllotoxin; Radiation-Sensitizing Agents; Swine; Taxoids; Tubulin; Tubulin Modulators; Vinblastine; Vinorelbine | 2008 |
Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates.
Topics: Animals; Cattle; Cell Line, Tumor; Colchicine; Fluorescent Antibody Technique; Glutathione; Humans; Inhibitory Concentration 50; Mice; Podophyllotoxin; Protein Multimerization; Protein Structure, Quaternary; Tubulin | 2010 |
Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin.
Topics: Animals; Binding Sites; Binding, Competitive; Cattle; Chromatography, Liquid; Colchicine; Docetaxel; Guanosine Triphosphate; Linear Models; Paclitaxel; Podophyllotoxin; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Taxoids; Thiazoles; Tubulin; Tubulin Modulators; Vinblastine; Vincristine | 2010 |
End-binding proteins sensitize microtubules to the action of microtubule-targeting agents.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cellular Senescence; Colchicine; Depsipeptides; Green Fluorescent Proteins; HeLa Cells; Humans; Lactones; Microscopy, Fluorescence; Microtubule-Associated Proteins; Microtubules; Models, Biological; Paclitaxel; Podophyllotoxin; Statistics, Nonparametric; Stilbenes; Tubulin Modulators; Vinblastine | 2013 |
Tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Colchicine; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Mercaptopurine; Models, Molecular; Podophyllotoxin; Podophyllum; Polymerization; Sulfur; Surface Plasmon Resonance; Temperature; Thioguanine; Tubulin; Tubulin Modulators | 2015 |
Discovery of a Series of Acridinones as Mechanism-Based Tubulin Assembly Inhibitors with Anticancer Activity.
Topics: Acridines; Antineoplastic Agents; Apoptosis; Binding Sites; Binding, Competitive; Cell Cycle; Cell Line, Tumor; Cell Movement; Colchicine; Drug Design; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Podophyllotoxin; Tubulin; Tubulin Modulators | 2016 |
Structural and Biochemical Characterization of the Interaction of Tubulin with Potent Natural Analogues of Podophyllotoxin.
Topics: Bursera; Cell Cycle; Colchicine; Humans; Lactones; Lignans; Microtubules; Molecular Structure; Podophyllotoxin; Protein Binding; Tubulin; Tubulin Modulators | 2016 |
Melatonin: inhibition of microtubule-based oral morphogenesis in Stentor coeruleus.
Topics: Ciliophora; Colchicine; Depression, Chemical; Drug Antagonism; Melatonin; Methylamines; Microscopy, Phase-Contrast; Microtubules; Morphogenesis; Niacinamide; Plants, Medicinal; Plants, Toxic; Podophyllum; Regeneration; Riboflavin | 1972 |
Definition of three classes of binding sites in isolated microtubule crystals.
Topics: Alkaloids; Animals; Binding Sites; Centrifugation, Density Gradient; Colchicine; Cyclic AMP; Cyclic GMP; Guanosine Triphosphate; Kinetics; Macromolecular Substances; Mathematics; Microtubules; Phosphates; Phosphorus Isotopes; Plants, Medicinal; Plants, Toxic; Podophyllum; Protein Binding; Radiation Effects; Sea Urchins; Spectrophotometry; Temperature; Thermodynamics; Tritium; Ultraviolet Rays; Vinblastine | 1972 |
Alterations in fertility induced by unilateral intrauterine instillation of cytotoxic compounds in rats.
Topics: Animals; Cadmium; Colchicine; Endometrium; Ethanol; Female; Fertility; Humans; Iodoacetates; Plants, Medicinal; Plants, Toxic; Podophyllum; Pregnancy; Rats; Thiotepa; Uterus | 1968 |
Inhibition of cilia regeneration by antineoplastic agents.
Topics: Antineoplastic Agents; Cilia; Ciliophora; Colchicine; Daunorubicin; Depression, Chemical; Dinitrophenols; Griseofulvin; Methylamines; Microscopy, Phase-Contrast; Microtubules; Mitosis; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Regeneration; Vinblastine; Vincristine | 1971 |
Nucleoside transport in mammalian cells. Inhibition by colchicine.
Topics: Adenosine; Alkaloids; Aminoisobutyric Acids; Animals; Carbon Isotopes; Carcinoma; Cell Line; Cells, Cultured; Colchicine; Cricetinae; Cytarabine; Dactinomycin; Fetus; Fibroblasts; Guanosine; HeLa Cells; Hexoses; Humans; Lung; Mouth Neoplasms; Nucleic Acids; Nucleosides; Phosphorus Isotopes; Plants, Medicinal; Plants, Toxic; Podophyllum; Skin; Thymidine; Tritium; Uridine | 1972 |
Properties of colchicine binding protein from chick embryo brain. Interactions with vinca alkaloids and podophyllotoxin.
Topics: Animals; Binding Sites; Brain Chemistry; Chick Embryo; Chromatography, Gel; Colchicine; Glutamates; Hydrogen-Ion Concentration; Microtubules; Molecular Weight; Nerve Tissue Proteins; Osmolar Concentration; Plants, Medicinal; Plants, Toxic; Podophyllum; Protein Binding; Sodium; Sodium Chloride; Vinblastine; Vincristine | 1970 |
The treatment of skin carcinoma with podophyllum derivatives.
Topics: Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Colchicine; Fluorouracil; Humans; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Skin Neoplasms | 1971 |
The stathmokinetic agents.
Topics: Animals; Antineoplastic Agents; Colchicine; Griseofulvin; Leukemia; Mice; Mitosis; Plants, Medicinal; Plants, Toxic; Podophyllum; Vinblastine; Vincristine | 1968 |
Effects of mitotic spindle inhibitors on neurotubules and neurofilaments in anterior horn cells.
Topics: Animals; Colchicine; Female; Male; Microscopy, Electron; Motor Neurons; Organoids; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Rabbits; Vinblastine | 1968 |
The biochemical events of mitosis. II. The in vivo and in vitro binding of colchicine in grasshopper embryos and its possible relation to inhibition of mitosis.
Topics: Animals; Chromatography, Gel; Chromatography, Thin Layer; Colchicine; Depression, Chemical; Dialysis; Insecta; Mitosis; Models, Biological; Molecular Weight; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Protein Binding; Proteins; Stimulation, Chemical; Tritium; Vinblastine | 1967 |
Podophyllin and colchicine changes in the vaginal mucosa of the virginal, pregnant and ovariectomized rat. A comparative study.
Topics: Animals; Castration; Colchicine; Female; Humans; Male; Mucous Membrane; Orchiectomy; Podophyllin; Podophyllum; Pregnancy; Pregnancy, Animal; Rats; Vagina | 1962 |
THE ROLE OF THE MITOTIC APPARATUS IN THE INTRACELLULAR LOCATION OF REOVIRUS ANTIGEN.
Topics: Amnion; Animals; Antigens; Cell Division; Colchicine; Fluorescent Antibody Technique; Podophyllum; Reoviridae; Research; Spindle Apparatus; Sulfhydryl Compounds; Tissue Culture Techniques; Vertebrates; Vinblastine; Virus Cultivation; Viruses | 1963 |
[CHEMOTHERAPY OF SKIN CANCER].
Topics: Antineoplastic Agents; Colchicine; Methotrexate; Podophyllum; Retinoids; Skin Neoplasms; Vitamin K | 1963 |
DRUGS OF CURRENT USE FOR THE TREATMENT OF CANCER AND ALLIED DISEASES.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Aziridines; Busulfan; Colchicine; Dactinomycin; Diethylstilbestrol; Estrogens; Fluorouracil; Gonadal Steroid Hormones; Mercaptopurine; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Podophyllum; Progestins; Quinones; Thiotepa; Triethylenemelamine; Urethane; Vinblastine | 1963 |
[EARLY DIAGNOSIS AND MEDICAL THERAPY OF MALIGNANT TUMORS].
Topics: Antineoplastic Agents; Busulfan; Colchicine; Early Diagnosis; Hodgkin Disease; Mechlorethamine; Mercaptopurine; Neoplasms; Phenylalanine; Podophyllum; Triethylenemelamine; Vinblastine | 1963 |
COMPARATIVE STUDIES OF THE ACTION OF CHEMOTHERAPEUTICS ON INDUCED AND TRANSPLANTED TUMORS.
Topics: Antineoplastic Agents; Colchicine; Cyclophosphamide; Mannomustine; Melphalan; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Podophyllum; Research; Skin Neoplasms | 1964 |
[REPERCUSSIONS OF NEUROLEPTIC AND ANTITUMOR AGENTS ON PRENATAL DEVELOPMENT].
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Antipsychotic Agents; Barbiturates; Colchicine; Dactinomycin; Folic Acid Antagonists; Glutethimide; Mice; Nitrogen Mustard Compounds; Parasympatholytics; Podophyllin; Podophyllum; Pregnancy; Pregnancy, Animal; Rabbits; Rats; Research; Thalidomide; Toxicology; Tranquilizing Agents; Urethane | 1964 |
EFFECT OF ANTIMITOTIC AGENTS ON INTRACELLULAR REOVIRUS ANTIGEN.
Topics: Antigens; Antimitotic Agents; Antineoplastic Agents; Cell Division; Colchicine; Cytoplasm; Pharmacology; Podophyllum; Research; Toxicology; Vinblastine; Viruses | 1964 |
[Laboratory experience with colchicine and podophylline].
Topics: Cells; Colchicine; Diploidy; Humans; Podophyllin; Podophyllum | 1950 |
Fluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells.
Topics: Antineoplastic Agents; Apoptosis; Biocatalysis; Blotting, Western; Caspase 9; Cell Cycle Checkpoints; Colchicine; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Fluorides; HeLa Cells; Humans; Inhibitory Concentration 50; Microtubules; Mitochondria; Models, Biological; Podophyllum; Signal Transduction; Time Factors | 2015 |