Page last updated: 2024-08-21

podophyllotoxin and anthricin

podophyllotoxin has been researched along with anthricin in 98 studies

Research

Studies (98)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (8.16)	18.7374
1990's	3 (3.06)	18.2507
2000's	22 (22.45)	29.6817
2010's	57 (58.16)	24.3611
2020's	8 (8.16)	2.80

Authors

Authors	Studies
Brewer, CF; Gensler, WJ; Horwitz, SB; Loike, JD; Sternlicht, H	1
Feringa, BL; Jansen, JF; Kellogg, RM; Konings, AW; Middel, O; Pras, N; van Oeveren, A; van Uden, W; Woerdenbag, HJ	1
Chai, H; Cruz, JG; Hernández, L; Mar, W; Novelo, M; Pereda-Miranda, R; Pezzuto, JM	1
Charlton, JL	1
But, PP; Hon, PM; Jiang, RW; Li, LL; Li, SL; Shaw, PC; Xu, HX; Ye, WC; Zhou, JR; Zhou, Y	1
Chen, H; Hua, HM; Li, ZL; Liu, XQ; Sun, YJ; Zhou, W	1
Chen, SW; Ding, YL; Huang, WT; Hui, L; Liu, J; Liu, JF	1
Chapuis, JC; Cragg, GM; Knight, JC; Melody, N; Pettit, GR; Searcy, JD; Tan, R	1
Arimoto, M; Numata, A; Yamaguchi, H; Yamamoto, K	1
Cole, JR; Jolad, SD; Wiedhopf, RM	1
Inamori, Y; Inoue, M; Ishida, T; Kozawa, M; Ohishi, H; Yamamoto, D	1
Baba, K; Inamori, Y; Ishida, T; Kato, Y; Kozawa, M; Kubo, M; Nomoto, K	1
Hashimoto, I; Hikino, H; Kiso, Y; Konno, C; Yagi, Y	1
Hashimoto, I; Hikino, H; Kiso, Y; Konno, C; Wakasa, H	1
Brown, E; Guenard, D; Robin, JP; Zavala, F	1
Bos, R; Koulman, A; Medarde, M; Pras, N; Quax, WJ	1
Alfermann, AW; Empt, U; Kuhlmann, S; Molog, GA; Petersen, M; Pras, N; van Uden, W	1
Ahn, BZ; Kim, SB; Kim, Y; You, YJ	1
Chikahisa, L; Inaba, Y; Masuda, T; Mizuguchi, S; Nakata, M; Okada, Y; Oyama, Y; Takeda, Y; Tanaka, T; Yamazaki, Y; Yonemori, S	1
Alfermann, AW; Arroo, RR; Eaton, G; Medarde, M; Petersen, M; Seidel, V; Windhövel, J; Woolley, JG	1
Ahn, BZ; Kim, Y; Nam, NH; You, YJ	2
Kranz, K; Petersen, M	1
Beekman, AC; Koulman, A; Pras, N; Quax, WJ	1
Chang, I; Choi, H; Hwang, JS; Lee, BG; Lee, J; Shin, HJ	1
Chang, HW; Ju, HK; Kim, MJ; Kim, SH; Lee, E; Lee, SH; Lin, CX; Moon, TC; Son, JK; Son, MJ	1
Chang, HW; Choi, HG; Ju, HK; Lee, SH; Lin, CX; Moon, TC; Son, JK; Son, MJ	1
Di, X; Gao, C; Gao, R; Tian, X; Xiao, H; Yu, X; Zhang, X	1
Chang, HW; Ha, K; Jin, MH; Kim, KJ; Kim, MJ; Lee, E; Lee, SH; Lin, CX; Moon, TC; Quan, Z; Yook, J	1
Bos, R; Clarkson, C; Ionkova, I; Jaroszewski, JW; Julsing, MK; Kayser, O; Koulman, A; Quax, WJ; Vasilev, NP; Woerdenbag, HJ	1
Ionkova, I; Julsing, MK; Kayser, O; Muntendam, R; Quax, WJ; Schneidman-Duhovny, D; Vasilev, NP; Woerdenbag, HJ; Wolfson, HJ	1
Jeong, TC; Jun, IH; Kang, MJ; Kim, DH; Kim, JH; Lee, SH; Lee, SK; Seo, YM; Yoo, HH	1
Chang, HW; Jeong, TC; Jin, M; Kim, CH; Kim, YK; Lee, E; Lee, SH; Moon, TC; Quan, Z; Suh, SJ; Yang, JH	1
Chang, HW; Chang, YC; Choi, HS; Jin, UH; Kim, CH; Kim, JR; Kim, SH; Lee, IS; Lee, YC; Moon, TC; Suh, SJ	1
Kusari, S; Lamshöft, M; Spiteller, M	1
Lee, YH; Lim, Y; Shin, SY; Yong, Y	1
Kim, CG; Lee, YH; Lim, Y; Shin, SY; Yong, Y	1
Jeong, SY; Jeong, TC; Jin, C; Kang, MJ; Kim, DH; Kim, Y; Lee, SH; Lee, SK; Yoo, HH	1
Chang, HW; Chang, YC; Jin, M; Kang, S; Kim, CH; Lee, E; Lee, SH; Lu, Y; Suh, SJ; Yang, JH	1
Chen, SW; Hui, L; Tian, X; Zhang, JQ; Zhang, ZW	1
Wang, JJ; Xu, H	1
An, S; Cheng, J; Gao, R; Sun, Q; Wang, X; Xiao, H; Xu, P; Zhang, S	1
Cheng, J; Gao, R; Hu, F; Sun, Q; Wang, LS; Xiao, H; Xu, P	1
Axelson, M; Beck, O; Bergqvist, M; Ekman, S; Eksborg, S; Harmenberg, J; Rönquist-Nii, Y	1
Hendrawati, O; Hille, J; Kayser, O; Quax, WJ; Woerdenbag, HJ	1
Doussot, J; Dupre, P; Falguieres, A; Ferroud, C; Hagege, D; Hano, C; Hendrawati, O; Laine, E; Lamblin, F; Lopez, T; Renouard, S	1
Chen, SW; Huang, WT; Hui, L; Jin, Y; Liu, J	1
Avila, J; Cerda-García-Rojas, CM; García-Mauriño, S; Gómez-Hurtado, MA; Hernández-Hernández, JD; Joseph-Nathan, P; Manríquez-Torres, JJ; Motilva, V; Román-Marín, LU; Talero, E; Torres-Valencia, JM; Valdez-Calderón, A; Velázquez-Jiménez, R	1
Aantjes, HG; Hendrawati, O; Kayser, O; Michiels, PJ; van Dam, A; Woerdenbag, HJ	1
Carpenter, CD; Gray, CA; Johnson, JA; O'Neill, T; Picot, N; Robichaud, GA; Webster, D	1
Ahn, SC; Chatterjee, B; Cho, HJ; Kim, KY; Kim, SH; Kim, SY; Mirkheshti, N; Park, YM; Song, CS; Yu, HS; Yu, SN	1
Abad, A; Del Olmo, E; Guerrero, E; López-Pérez, JL; Montenegro, G; San Feliciano, A	1
Feng, G; Jin, QA; Liu, YQ; Peng, ZQ; Tian, X; Yang, L; Zhang, J; Zhang, ZW	1
Chen, M; Duan, H; Jiang, Z; Miao, J; Sun, L; Wang, Y; Wu, M; Zhang, L; Zhang, S; Zhang, X; Zhu, X	1
Wang, J; Xu, H; Yu, X; Zhi, X	2
Fang, S; Han, C; Li, H; Liu, Y; Lu, Y; Ma, Y; Zhao, C; Zhao, Y	1
Jiang, ZZ; Khaled, M; Zhang, LY	1
Chen, M; Duan, H; Gao, Q; Jiang, Z; Song, Y; Sun, L; Wang, Y; Wu, M; Zhang, L; Zhang, S; Zhu, X	1
Li, MF; Li, TT; Li, W; Su, XM; Yang, DL; Zhou, LL	1
Chen, SW; Ding, YL; Hui, L; Liu, JF; Qin, WW; Sang, CY; Zhao, J	1
Chen, Y; Jia, LL; Li, F; Liu, L; Liu, XD; Yang, Y; Zhang, J; Zhong, ZY; Zhu, X	1
Chen, SW; Hui, L; Liu, JF; Qin, WW; Sang, CY; Xu, XH	1
Bai, XY; Wang, CH; Wang, CY	1
Beauregard, AP; Benzina, S; Bos, A; Carroll, M; Colquhoun, CD; Gray, CA; Harquail, J; Jean, S; Robichaud, GA	1
Guerram, M; Jiang, ZZ; Wang, B; Wang, YR; Xu, Y; Zhang, LY; Zhu, X	1
Boitel, M; Colas, C; Cong, LH; Corbin, C; Dauwe, R; Doussot, J; Fliniaux, O; Gontier, E; Hano, C; Jullian, N; Laberche, JC; Lamblin, F; Lequart, M; Mesnard, F; Molinié, R; Pilard, S; Renouard, S; Vinchon, S	1
Guerram, M; Jiang, ZZ; Sun, L; Zhang, LY; Zhu, X	1
Bogucka-Kocka, A; Cieśla, Ł; Kocki, J; Kubrak, T; Och, A; Och, M; Pecio, Ł; Stochmal, A	1
Gao, W; Gong, JH; Guan, YB; Sun, YJ; Wang, JM; Wang, Y; Zhang, YL; Zhao, X	1
Guerram, M; Jiang, Z; Shi, W; Sun, L; Tian, C; Wang, B; Wang, Y; Zhang, L; Zhu, X	1
Chen, S; Hui, L; Jia, Q; Ma, M; Sang, C; Wang, D; Wang, M; Wang, X	1
Chi, G; Feng, C; Feng, J; Ge, P; Jia, H; Lu, B; Luo, T; Luo, Y; Ma, D; Wang, C; Wang, Y	1
Fu, J; Gao, Y; Guo, Q; Tang, Y; Zhang, S; Zhu, X	1
Chen, C; Geng, WY; Luo, DQ; Song, XM; Wang, CC; Wang, Z; Xu, H	1
Chen, Y; Ling, Z; Liu, F; Liu, L; Liu, X; Tang, X; Wang, F; Wang, Z; Xie, Q; Zhao, K; Zhong, Z	1
Belaaloui, G; Jiang, ZZ; Khaled, M; Zhang, LY; Zhu, X	1
Colas, C; Corbin, C; Doussot, J; Dupré, P; Hano, C; Kiss, R; Lainé, E; Lamblin, F; Mathieu, V; Maunit, B; Molinié, R; Montguillon, J; Moreno Y Banuls, L; Renouard, S	1
Chen, F; Guan, ZY; Tang, YJ; Yin, P; Zhao, W; Zhou, C	1
Chen, SW; Guan, XW; Hui, L; Jin, YX; Xiang, R	1
Ahn, SC; Ji, JH; Kim, KY; Kim, SH; Kim, YW; Nam, HW; Park, SG; Son, KM; Suh, JT; Yu, SN	1
Huang, L; Shen, Y; Shi, D; Sun, C; Sun, R; Tang, L; Tu, J; Wang, Y; Webster, TJ	1
Andrus, MB; Ess, DH; Kwon, DH; Rencher, BD; Saavedra, DI; Smith, SJ	1
Cai, Q; Chen, Q; Hao, H; Wang, G; Wu, B; Zang, X; Zhang, J; Zheng, X; Zhou, F; Zhu, X	1
Alcazar, R; Bonfill, M; Cusidó, RM; Lalaleo, L; Palazon, J; Risueño, MC; Testillano, P	1
Li, YN; Shen, Y; Sun, RN; Tu, JS; Yu, YL; Zhang, Y	1
Ahn, SC; Baek, SY; Kim, JH; Kim, KJ; Kim, KY; Kim, SC; Kim, SH; Kim, YW; Lee, EH; Lee, SG; Oh, TW; Park, KI; Park, SG; Yu, SN	1
Bao, Y; Gao, W; Wang, W; Zhang, D; Zhang, L; Zhao, Z	1
Bae, WK; Gamage, CDB; Kim, E; Kim, H; Kim, KK; Park, SY; Shim, JH; Taş, İ; Yang, Y; Yoon, G; Zhou, R	1
Alizade, V; Atha, D; Borris, RP; Hatada, AE; Khutsishvili, M; Ko'omoa-Lange, DL; Lange, I; Qiao, Y; Sunada, NK	1
Chaurasiya, B; Chen, D; Li, Y; Shen, Y; Sun, R; Tang, B; Tu, J; Yu, C; Yu, Y; Zu, C	1
Fan, JT; Geng, Y; Jiang, HZ; Li, YN; Ma, CY; Ning, N; Song, L	1
Chae, JI; Cho, SS; Choi, JS; Kwak, AW; Lee, MH; Shim, JH; Yoon, G	1
Chae, JI; Cho, SS; Kim, E; Kim, HS; Kwak, AW; Lee, MH; Oh, HN; Seo, JH; Shim, JH; Yoon, G	1
Decembrino, D; Girhard, M; Knöfel, R; Raffaele, A; Urlacher, VB	1
Chan, NL; Chang, WC; Chien, TC; Han, MR; Lin, HY; Tang, H; Tu, YH; Wu, MH; Yang, ZJ	1
Abbaszadeh, H; Mottaghi, S	1
Chae, JI; Jeon, YJ; Park, S; Seo, JH; Shim, JH; Yoon, G	1

Reviews

4 review(s) available for podophyllotoxin and anthricin

Article	Year
Antiviral activity of lignans. Journal of natural products, 1998, Volume: 61, Issue:11 Topics: Animals; Antiviral Agents; Humans; Lignans; Plants, Medicinal; Viruses	1998
Deoxypodophyllotoxin: a promising therapeutic agent from herbal medicine. Journal of ethnopharmacology, 2013, Aug-26, Volume: 149, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; China; Drugs, Chinese Herbal; Humans; Molecular Structure; Plants, Medicinal; Podophyllotoxin	2013
Traditional Chinese medicine: a treasured natural resource of anticancer drug research and development. The American journal of Chinese medicine, 2014, Volume: 42, Issue:3 Topics: Alkaloids; Amphibian Venoms; Animals; Antineoplastic Agents, Phytogenic; Berberine; Diterpenes; Drug Combinations; Drug Discovery; Drugs, Chinese Herbal; Epoxy Compounds; Flavonoids; Humans; Matrines; Medicine, Chinese Traditional; Molecular Conformation; Molecular Targeted Therapy; Neoplasms; Phenanthrenes; Plants, Medicinal; Podophyllotoxin; Quinolizines	2014
A comprehensive insight into the antineoplastic activities and molecular mechanisms of deoxypodophyllotoxin: Recent trends, challenges, and future outlook. European journal of pharmacology, 2022, Aug-05, Volume: 928 Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Drugs, Chinese Herbal; Humans; Lignans; Neoplasms; Phosphatidylinositol 3-Kinases; Podophyllotoxin	2022

Other Studies

94 other study(ies) available for podophyllotoxin and anthricin

Article	Year
Conformational analysis of podophyllotoxin and its congeners. Structure--activity relationship in microtubule assembly. Journal of medicinal chemistry, 1979, Volume: 22, Issue:3 Topics: Animals; Brain; In Vitro Techniques; Magnetic Resonance Spectroscopy; Microtubules; Molecular Conformation; Podophyllotoxin; Structure-Activity Relationship	1979
Synthesis and cytotoxicity of novel lignans. Journal of medicinal chemistry, 1995, Jun-09, Volume: 38, Issue:12 Topics: Antineoplastic Agents; Carcinoma, Small Cell; Humans; Lignans; Lung Neoplasms; Tumor Cells, Cultured	1995
Cytotoxic constituents from Hyptis verticillata. Journal of natural products, 1993, Volume: 56, Issue:10 Topics: Animals; Antineoplastic Agents, Phytogenic; Artemia; Candida albicans; Drug Screening Assays, Antitumor; Humans; Leukemia P388; Mexico; Mice; Microbial Sensitivity Tests; Plants, Medicinal; Podophyllotoxin; Rats	1993
Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines. Journal of natural products, 2007, Volume: 70, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Berberidaceae; Drug Screening Assays, Antitumor; Humans; Lignans; Male; Molecular Structure; Plant Roots; Plants, Medicinal; Podophyllotoxin; Prostatic Neoplasms; Rhizome; Tumor Cells, Cultured	2007
Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi. Bioorganic & medicinal chemistry letters, 2011, Jun-15, Volume: 21, Issue:12 Topics: Antineoplastic Agents, Phytogenic; Berberidaceae; Cell Line, Tumor; Cell Survival; Glucosides; HeLa Cells; Humans; Inhibitory Concentration 50; Lignans; Magnetic Resonance Spectroscopy; Plant Roots; Podophyllotoxin	2011
Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7. European journal of medicinal chemistry, 2012, Volume: 49 Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; Drugs, Chinese Herbal; Enzyme Activation; Fluorouracil; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; Neoplasms; Podophyllotoxin	2012
Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications. Journal of natural products, 2016, Mar-25, Volume: 79, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Euphorbiaceae; Humans; Mice; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship	2016
[Studies on the constituents of the seeds of Hernandia ovigera L. (author's transl)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1979, Volume: 99, Issue:6 Topics: Benzyl Compounds; Drugs, Chinese Herbal; Lactones; Lignans; Plant Extracts; Plants, Medicinal; Podophyllin; Podophyllotoxin; Seeds	1979
Cytotoxic agents from Bursera morelensis (Burseraceae): deoxypodophyllotoxin and a new lignan, 5'-desmethoxydeoxypodophyllotoxin. Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:6 Topics: Animals; Carcinoma, Squamous Cell; Drugs, Chinese Herbal; Humans; Leukemia, Experimental; Neoplasms, Experimental; Plants, Medicinal; Podophyllotoxin	1977
Study on conformations--biological activities relationships for podophyllotoxin analogues based on crystal structure of deoxypodophyllotoxin (anthricin). Chemical & pharmaceutical bulletin, 1988, Volume: 36, Issue:9 Topics: Crystallization; Drugs, Chinese Herbal; Insecticides; Molecular Conformation; Plants; Podophyllotoxin; Structure-Activity Relationship; X-Ray Diffraction	1988
The biological actions of deoxypodophyllotoxin (anthricin). I. Physiological activities and conformational analysis of deoxypodophyllotoxin. Chemical & pharmaceutical bulletin, 1985, Volume: 33, Issue:2 Topics: Animals; Decapoda; Drugs, Chinese Herbal; Fishes; Insecticides; Lethal Dose 50; Molecular Conformation; Plants; Podophyllotoxin	1985
Liver-protective actions of desoxypodophyllotoxin and its analogs. Journal of pharmacobio-dynamics, 1982, Volume: 5, Issue:8 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Galactosamine; Liver; Male; Mice; Podophyllotoxin; Structure-Activity Relationship	1982
Protective action of desoxypodophyllotoxin on D-galactosamine-induced liver lesion in rats. Chemical & pharmaceutical bulletin, 1982, Volume: 30, Issue:10 Topics: Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Galactosamine; Male; Podophyllotoxin; Rats; Rats, Inbred Strains	1982
Structure--antitubulin activity relationship in steganacin congeners and analogues. Inhibition of tubulin polymerization in vitro by (+/-)-isodeoxypodophyllotoxin. Journal of medicinal chemistry, 1980, Volume: 23, Issue:5 Topics: Colchicine; Depression, Chemical; Drugs, Chinese Herbal; Kinetics; Podophyllotoxin; Protein Binding; Structure-Activity Relationship; Tubulin	1980
A fast and simple GC MS method for lignan profiling in Anthriscus sylvestris and biosynthetically related Plant species. Planta medica, 2001, Volume: 67, Issue:9 Topics: 4-Butyrolactone; Apiaceae; Dioxoles; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lignans; Plant Extracts; Podophyllotoxin	2001
Deoxypodophyllotoxin 6-hydroxylase, a cytochrome P450 monooxygenase from cell cultures of Linum flavum involved in the biosynthesis of cytotoxic lignans. Planta, 2001, Volume: 214, Issue:2 Topics: Cells, Cultured; Cytochrome c Group; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Flax; Hydrogen-Ion Concentration; Lignans; Microsomes; NAD; NADP; Podophyllotoxin; Substrate Specificity	2001
Deoxypodophyllotoxin; the cytotoxic and antiangiogenic component from Pulsatilla koreana. Planta medica, 2002, Volume: 68, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Lewis Lung; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Endothelium, Vascular; Etoposide; Humans; Medicine, East Asian Traditional; Mice; Plant Extracts; Plant Roots; Podophyllotoxin; Ranunculaceae; Tumor Cells, Cultured; Umbilical Veins	2002
Flow cytometric estimation on cytotoxic activity of leaf extracts from seashore plants in subtropical Japan: isolation, quantification and cytotoxic action of (-)-deoxypodophyllotoxin. Phytotherapy research : PTR, 2002, Volume: 16, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Cell Division; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flow Cytometry; Humans; Japan; K562 Cells; Magnoliopsida; Methanol; Plant Extracts; Plant Leaves; Podophyllotoxin; Time Factors; Tumor Cells, Cultured	2002
Biosynthesis of podophyllotoxin in Linum album cell cultures. Planta, 2002, Volume: 215, Issue:6 Topics: Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Carbon Isotopes; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Cinnamates; Coenzyme A Ligases; Coumaric Acids; Drugs, Chinese Herbal; Flax; Hydrogen-Ion Concentration; Lignans; Mass Spectrometry; Molecular Structure; Phenylalanine Ammonia-Lyase; Podophyllotoxin	2002
Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity. Bioorganic & medicinal chemistry letters, 2002, Dec-02, Volume: 12, Issue:23 Topics: Amino Acids; Antineoplastic Agents; Carbamates; Carbonates; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Hydrolysis; Lethal Dose 50; Podophyllotoxin; Prodrugs; Structure-Activity Relationship; Tumor Cells, Cultured	2002
Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Animals; Antineoplastic Agents, Phytogenic; Cells, Cultured; Drug Carriers; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Esters; Fatty Acids, Unsaturated; Mice; Podophyllotoxin	2003
Beta-peltatin 6-O-methyltransferase from suspension cultures of Linum nodiflorum. Phytochemistry, 2003, Volume: 64, Issue:2 Topics: Drugs, Chinese Herbal; Enzyme Inhibitors; Flax; Hydrogen-Ion Concentration; Lignans; Methyltransferases; Podophyllotoxin; S-Adenosylmethionine; Substrate Specificity; Temperature; Time Factors	2003
The bioconversion process of deoxypodophyllotoxin with Linum flavum cell cultures. Planta medica, 2003, Volume: 69, Issue:8 Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flax; Humans; Phytotherapy; Podophyllotoxin	2003
Deoxypodophyllotoxin reduces skin pigmentation of brown Guinea pigs. Planta medica, 2004, Volume: 70, Issue:4 Topics: Administration, Cutaneous; Animals; Apiaceae; Dermatologic Agents; Drugs, Chinese Herbal; Guinea Pigs; Phytotherapy; Plant Extracts; Plant Roots; Podophyllotoxin; Skin Pigmentation; Ultraviolet Rays	2004
Deoxypodophyllotoxin, a naturally occurring lignan, inhibits the passive cutaneous anaphylaxis reaction. Planta medica, 2004, Volume: 70, Issue:5 Topics: Animals; Apiaceae; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hypersensitivity, Immediate; Injections, Intraperitoneal; Injections, Intravenous; Lignans; Male; Passive Cutaneous Anaphylaxis; Phytotherapy; Plant Extracts; Plant Roots; Podophyllotoxin; Rats; Rats, Sprague-Dawley	2004
Dual inhibition of cyclooxygenases-2 and 5-lipoxygenase by deoxypodophyllotoxin in mouse bone marrow-derived mast cells. Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:6 Topics: Animals; Apiaceae; Arachidonate 5-Lipoxygenase; Bone Marrow Cells; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Inhibitors; Isoenzymes; Lipoxygenase Inhibitors; Male; Mast Cells; Mice; Mice, Inbred BALB C; Plant Extracts; Plant Roots; Podophyllotoxin; Prostaglandin-Endoperoxide Synthases	2004
Insecticidal activity of deoxypodophyllotoxin, isolated from Juniperus sabina L, and related lignans against larvae of Pieris rapae L. Pest management science, 2004, Volume: 60, Issue:11 Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Insecticides; Juniperus; Larva; Lepidoptera; Lethal Dose 50; Podophyllotoxin; Spectrum Analysis	2004
Deoxypodophyllotoxin (DPT) inhibits eosinophil recruitment into the airway and Th2 cytokine expression in an OVA-induced lung inflammation. Planta medica, 2006, Volume: 72, Issue:9 Topics: Animals; Anti-Asthmatic Agents; Apiaceae; Arginase; Asthma; Cell Movement; Chemokine CCL11; Chemokines, CC; Cytokines; Drugs, Chinese Herbal; Eosinophils; Female; Gene Expression Regulation; Mice; Mice, Inbred BALB C; Ovalbumin; Plant Preparations; Pneumonia; Podophyllotoxin; Protein Isoforms; RNA, Messenger; Th2 Cells	2006
Bioconversion of deoxypodophyllotoxin into epipodophyllotoxin in E. coli using human cytochrome P450 3A4. Journal of biotechnology, 2006, Nov-10, Volume: 126, Issue:3 Topics: Biotransformation; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Escherichia coli; Genetic Enhancement; Humans; Podophyllotoxin; Protein Engineering; Recombinant Proteins	2006
Metabolic stereoselectivity of cytochrome P450 3A4 towards deoxypodophyllotoxin: In silico predictions and experimental validation. European journal of medicinal chemistry, 2008, Volume: 43, Issue:6 Topics: Algorithms; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Drugs, Chinese Herbal; Humans; Models, Molecular; Podophyllotoxin; Recombinant Proteins	2008
Characterization of in vitro metabolites of deoxypodophyllotoxin in human and rat liver microsomes using liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 2008, Volume: 22, Issue:1 Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Cytochromes; DNA, Complementary; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; In Vitro Techniques; Insecticides; Isoenzymes; Male; Microsomes, Liver; Podophyllotoxin; Protons; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tandem Mass Spectrometry	2008
The naturally occurring flavolignan, deoxypodophyllotoxin, inhibits lipopolysaccharide-induced iNOS expression through the NF-kappaB activation in RAW264.7 macrophage cells. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:7 Topics: Animals; Apiaceae; Blotting, Western; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA; Drugs, Chinese Herbal; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Indicators and Reagents; Lipopolysaccharides; Luciferases; Macrophages; Magnetic Resonance Spectroscopy; Mice; Nitric Oxide Synthase Type II; Plant Roots; Podophyllotoxin; Transcription Factor RelA; Transfection	2008
Deoxypodophyllotoxin, flavolignan, from Anthriscus sylvestris Hoffm. inhibits migration and MMP-9 via MAPK pathways in TNF-alpha-induced HASMC. Vascular pharmacology, 2009, Volume: 51, Issue:1 Topics: Aorta; Apiaceae; Cell Migration Inhibition; Cells, Cultured; Drugs, Chinese Herbal; Humans; Lignans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Myocytes, Smooth Muscle; Plant Extracts; Plant Roots; Podophyllotoxin; Protease Inhibitors; Tumor Necrosis Factor-alpha	2009
Aspergillus fumigatus Fresenius, an endophytic fungus from Juniperus communis L. Horstmann as a novel source of the anticancer pro-drug deoxypodophyllotoxin. Journal of applied microbiology, 2009, Volume: 107, Issue:3 Topics: Antineoplastic Agents, Phytogenic; Aspergillus fumigatus; Bacteria; Chromatography, Liquid; Drugs, Chinese Herbal; Juniperus; Mass Spectrometry; Mycelium; Podophyllotoxin; Polymerase Chain Reaction; RNA, Ribosomal, 28S; Sequence Analysis, DNA	2009
Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15 Topics: Caspase 3; Caspase 7; Caspases; Cell Cycle; Chemistry, Pharmaceutical; Cyclin A; Cyclin B1; Drugs, Chinese Herbal; Flow Cytometry; HeLa Cells; Humans; Microscopy, Fluorescence; Phytotherapy; Plant Extracts; Plant Roots; Plants, Medicinal; Podophyllotoxin	2009
Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells. Cancer letters, 2010, Jan-28, Volume: 287, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Ataxia Telangiectasia Mutated Proteins; bcl-2-Associated X Protein; Caspase 3; Caspase 7; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Proliferation; Cell Survival; Checkpoint Kinase 2; DNA Fragmentation; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Female; G2 Phase; HeLa Cells; Humans; Podophyllotoxin; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Time Factors; Tubulin Modulators; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Uterine Cervical Neoplasms	2010
Inhibitory effects of deoxypodophyllotoxin from Anthriscus sylvestris on human CYP2C9 and CYP3A4. Planta medica, 2010, Volume: 76, Issue:7 Topics: Apiaceae; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Humans; Microsomes, Liver; Podophyllotoxin	2010
Deoxypodophyllotoxin inhibits the expression of intercellular adhesion molecule-1 induced by tumor necrosis factor-alpha in murine lung epithelial cells. Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Apiaceae; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Epithelial Cells; Genes, Reporter; I-kappa B Proteins; Intercellular Adhesion Molecule-1; Lung; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Plant Extracts; Plant Roots; Podophyllotoxin; Promoter Regions, Genetic; RNA, Messenger; Tumor Necrosis Factor-alpha	2010
First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin. European journal of medicinal chemistry, 2010, Volume: 45, Issue:4 Topics: Animals; Antioxidants; Cell Line; Drugs, Chinese Herbal; Humans; Podophyllotoxin; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spin Labels	2010
Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. Bioorganic & medicinal chemistry letters, 2010, Apr-15, Volume: 20, Issue:8 Topics: Animals; Biological Products; Drug Design; Drugs, Chinese Herbal; Insecticides; Larva; Moths; Podophyllotoxin	2010
Pharmacological effect of deoxypodophyllotoxin: a medicinal agent of plant origin, on mammalian neurons. Neurotoxicology, 2010, Volume: 31, Issue:6 Topics: Animals; Calcium; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ganglia, Spinal; Membrane Potentials; Neurons; Plant Extracts; Plants, Medicinal; Podophyllotoxin; Rats; Rats, Sprague-Dawley	2010
[Effect of deoxypodophyllotoxin on membrane potential of dorsal unpaired median neurons and its relationship with sodium channel]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2010, Volume: 28, Issue:10 Topics: Animals; Cells, Cultured; Drugs, Chinese Herbal; Ganglia, Invertebrate; Membrane Potentials; Neurons; Periplaneta; Podophyllotoxin; Sodium Channels	2010
Determination of picropodophyllin and its isomer podophyllotoxin in human serum samples with electrospray ionization of hexylamine adducts by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Feb-15, Volume: 879, Issue:5-6 Topics: Adult; Aged, 80 and over; Amines; Animals; Chromatography, Liquid; Drug Stability; Drugs, Chinese Herbal; Female; Humans; Least-Squares Analysis; Male; Mice; Podophyllotoxin; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Swine; Tandem Mass Spectrometry	2011
Seasonal variations in the deoxypodophyllotoxin content and yield of Anthriscus sylvestris L. (Hoffm.) grown in the field and under controlled conditions. Journal of agricultural and food chemistry, 2011, Aug-10, Volume: 59, Issue:15 Topics: Apiaceae; Drugs, Chinese Herbal; Plant Extracts; Podophyllotoxin; Seasons	2011
Podophyllotoxin and deoxypodophyllotoxin in Juniperus bermudiana and 12 other Juniperus species: optimization of extraction, method validation, and quantification. Journal of agricultural and food chemistry, 2011, Aug-10, Volume: 59, Issue:15 Topics: Chemical Fractionation; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Juniperus; Plant Extracts; Podophyllotoxin	2011
Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents. European journal of medicinal chemistry, 2011, Volume: 46, Issue:9 Topics: Antineoplastic Agents; Cell Line, Tumor; Drugs, Chinese Herbal; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Podophyllotoxin; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared	2011
Absolute configuration of podophyllotoxin related lignans from Bursera fagaroides using vibrational circular dichroism. Phytochemistry, 2011, Volume: 72, Issue:17 Topics: 4-Butyrolactone; Adenocarcinoma; Antineoplastic Agents, Phytogenic; Benzofurans; Bursera; Cell Line, Tumor; Circular Dichroism; Colonic Neoplasms; Dioxoles; Drugs, Chinese Herbal; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Phytotherapy; Plant Extracts; Plant Exudates; Podophyllotoxin	2011
Identification of lignans and related compounds in Anthriscus sylvestris by LC-ESI-MS/MS and LC-SPE-NMR. Phytochemistry, 2011, Volume: 72, Issue:17 Topics: Apiaceae; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Plant Extracts; Plant Roots; Podophyllotoxin; Spectrometry, Mass, Electrospray Ionization	2011
Anti-mycobacterial natural products from the Canadian medicinal plant Juniperus communis. Journal of ethnopharmacology, 2012, Sep-28, Volume: 143, Issue:2 Topics: Anti-Bacterial Agents; Biological Products; Canada; Carboxylic Acids; Diterpenes; Drugs, Chinese Herbal; HEK293 Cells; Humans; Juniperus; Medicine, Traditional; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Podophyllotoxin; Tetrahydronaphthalenes	2012
Interplay of reactive oxygen species, intracellular Ca2+ and mitochondrial homeostasis in the apoptosis of prostate cancer cells by deoxypodophyllotoxin. Journal of cellular biochemistry, 2013, Volume: 114, Issue:5 Topics: Apoptosis; bcl-2-Associated X Protein; Calcium; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Egtazic Acid; Enzyme Activation; G2 Phase Cell Cycle Checkpoints; Homeostasis; Humans; Intracellular Space; M Phase Cell Cycle Checkpoints; Male; Membrane Potential, Mitochondrial; Mitochondria; Models, Biological; Podophyllotoxin; Prostatic Neoplasms; Protein Transport; Reactive Oxygen Species	2013
Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharmaceutical biology, 2013, Volume: 51, Issue:5 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carbazoles; Cell Line, Tumor; Disease Models, Animal; Drugs, Chinese Herbal; HT29 Cells; Humans; Indomethacin; Inflammation; Juniperus; Male; Mice; Naphthalenes; Neoplasms; Pain; Plant Leaves; Podophyllotoxin	2013
Antifeedant activity of spin-labeled derivatives of deoxypodophyllotoxin against Brontispa longissima larvae. Natural product communications, 2013, Volume: 8, Issue:2 Topics: Animals; Coleoptera; Drugs, Chinese Herbal; Larva; Podophyllotoxin; Spin Labels; Structure-Activity Relationship	2013
Deoxypodophyllotoxin exerts both anti-angiogenic and vascular disrupting effects. The international journal of biochemistry & cell biology, 2013, Volume: 45, Issue:8 Topics: Amides; Angiogenesis Inhibitors; Animals; Blood Vessels; Cell Cycle; Cell Movement; Cell Proliferation; Chickens; Chorioallantoic Membrane; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Drugs, Chinese Herbal; Human Umbilical Vein Endothelial Cells; Humans; In Vitro Techniques; Male; Mice, Nude; Microtubules; Neovascularization, Pathologic; Neovascularization, Physiologic; Paclitaxel; Podophyllotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Xenograft Model Antitumor Assays	2013
Synthesis and insecticidal activity of new deoxypodophyllotoxin-based phenazine analogues against Mythimna separata Walker. Journal of agricultural and food chemistry, 2013, Jul-03, Volume: 61, Issue:26 Topics: Animals; China; Drugs, Chinese Herbal; Insecticides; Larva; Lepidoptera; Phenazines; Podophyllotoxin; Pupa	2013
Biological evaluation and molecular modelling study of podophyllotoxin derivatives as potent inhibitors of tubulin polymerization. Chemical biology & drug design, 2013, Volume: 82, Issue:1 Topics: Antineoplastic Agents; Binding Sites; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Drugs, Chinese Herbal; HeLa Cells; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Molecular Docking Simulation; Podophyllotoxin; Thermodynamics; Tubulin; Tubulin Modulators	2013
Deoxypodophyllotoxin triggers necroptosis in human non-small cell lung cancer NCI-H460 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2013, Volume: 67, Issue:8 Topics: Animals; Antineoplastic Agents, Phytogenic; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Culture Techniques; Cell Death; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Humans; Lung Neoplasms; Male; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Necrosis; Podophyllotoxin; Reactive Oxygen Species; Xenograft Model Antitumor Assays	2013
Relationship between podophyllotoxin accumulation and soil nutrients and the influence of Fe2+ and Mn2+ on podophyllotoxin biosynthesis in Podophyllum hexandrum tissue culture. Plant physiology and biochemistry : PPB, 2013, Volume: 71 Topics: Drugs, Chinese Herbal; Iron; Manganese; Podophyllotoxin; Podophyllum; Soil; Tissue Culture Techniques	2013
Synthesis and evaluation of the cell cycle arrest and CT DNA interaction properties of 4β-amino-4'-O-demethyl-4-deoxypodophyllotoxins. Bioorganic & medicinal chemistry, 2013, Nov-15, Volume: 21, Issue:22 Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cattle; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin B1; DNA; Drugs, Chinese Herbal; G2 Phase Cell Cycle Checkpoints; HeLa Cells; Hep G2 Cells; Humans; M Phase Cell Cycle Checkpoints; Microtubules; Piperazines; Podophyllotoxin; Tubulin Modulators; Tumor Suppressor Protein p53	2013
Validated LC-MS/MS assay for quantitative determination of deoxypodophyllotoxin in rat plasma and its application in pharmacokinetic study. Journal of pharmaceutical and biomedical analysis, 2014, Volume: 88 Topics: Animals; Area Under Curve; Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drugs, Chinese Herbal; Female; Male; Plant Extracts; Plants, Medicinal; Podophyllotoxin; Rats; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2014
DPMA, a deoxypodophyllotoxin derivative, induces apoptosis and anti-angiogenesis in non-small cell lung cancer A549 cells. Bioorganic & medicinal chemistry letters, 2013, Dec-15, Volume: 23, Issue:24 Topics: Adenosine; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Line, Tumor; Drugs, Chinese Herbal; Human Umbilical Vein Endothelial Cells; Humans; Lung Neoplasms; Neovascularization, Physiologic; Podophyllotoxin; Signal Transduction; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A	2013
Deoxypodophyllotoxin isolated from Juniperus communis induces apoptosis in breast cancer cells. Anti-cancer agents in medicinal chemistry, 2015, Volume: 15, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biological Products; Breast Neoplasms; Carboxylic Acids; Caspases; Cell Line, Tumor; Diterpenes; Drugs, Chinese Herbal; Female; Humans; Juniperus; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Plant Extracts; Plants, Medicinal; Podophyllotoxin; Signal Transduction; Tetrahydronaphthalenes	2015
Synthesis and insecticidal activity of new deoxypodophyllotoxin derivatives modified in the D-ring. Bioorganic & medicinal chemistry letters, 2014, Sep-15, Volume: 24, Issue:18 Topics: Animals; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Insecticides; Models, Molecular; Molecular Conformation; Moths; Podophyllotoxin; Structure-Activity Relationship	2014
Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in SGC-7901 cells and inhibits tumor growth in vivo. Molecules (Basel, Switzerland), 2015, Jan-20, Volume: 20, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Caspases; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Drugs, Chinese Herbal; Enzyme Activation; Female; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; Mice, Nude; Microtubules; Microvessels; Podophyllotoxin; Proto-Oncogene Proteins c-bcl-2; Stomach Neoplasms; Xenograft Model Antitumor Assays	2015
Kinetics of glucosylated and non-glucosylated aryltetralin lignans in Linum hairy root cultures. Phytochemistry, 2015, Volume: 115 Topics: Drugs, Chinese Herbal; Flax; Glycosylation; Kinetics; Lignans; Molecular Structure; Plant Roots; Podophyllotoxin	2015
Antineoplastic effects of deoxypodophyllotoxin, a potent cytotoxic agent of plant origin, on glioblastoma U-87 MG and SF126 cells. Pharmacological reports : PR, 2015, Volume: 67, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspases; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Count; Cell Cycle; Cell Line, Tumor; Cyclin B1; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Glioblastoma; Humans; Membrane Potential, Mitochondrial; Podophyllotoxin	2015
Study of cytotoxic activity, podophyllotoxin, and deoxypodophyllotoxin content in selected Juniperus species cultivated in Poland. Pharmaceutical biology, 2015, Volume: 53, Issue:6 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Coloring Agents; Drugs, Chinese Herbal; Humans; Juniperus; Leukemia; Plant Leaves; Podophyllotoxin; Poland; Trypan Blue	2015
Purity Assessment of Aryltetralin Lactone Lignans by Quantitative 1H Nuclear Magnetic Resonance. Molecules (Basel, Switzerland), 2015, May-26, Volume: 20, Issue:6 Topics: Chromatography, High Pressure Liquid; Dinitrobenzenes; Drugs, Chinese Herbal; Lactones; Lignans; Podophyllotoxin; Proton Magnetic Resonance Spectroscopy; Reference Standards	2015
Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activatio. Oncotarget, 2015, Oct-06, Volume: 6, Issue:30 Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Cytoskeleton; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Female; HeLa Cells; Human Umbilical Vein Endothelial Cells; Humans; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Neovascularization, Physiologic; Podophyllotoxin; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; rhoA GTP-Binding Protein; RNA Interference; Signal Transduction; Stomach Neoplasms; Time Factors; Transfection; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays; Zebrafish	2015
Newly synthesized podophyllotoxin derivative, LJ12, induces apoptosis and mitotic catastrophe in non-small cell lung cancer cells in vitro. Molecular medicine reports, 2016, Volume: 13, Issue:1 Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Drugs, Chinese Herbal; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methionine; Microtubules; Mitosis; Neoplasm Proteins; Podophyllotoxin	2016
Deoxypodophyllotoxin triggers parthanatos in glioma cells via induction of excessive ROS. Cancer letters, 2016, Feb-28, Volume: 371, Issue:2 Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Antioxidants; Apoptosis Inducing Factor; Brain Neoplasms; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glioma; Humans; Membrane Potential, Mitochondrial; Mice, Inbred BALB C; Mice, Nude; Oxidative Stress; Podophyllotoxin; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Reactive Oxygen Species; RNA Interference; Signal Transduction; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays	2016
Design and synthesis of novel 4'-demethyl-4-deoxypodophyllotoxin derivatives as potential anticancer agents. Bioorganic & medicinal chemistry letters, 2016, Feb-15, Volume: 26, Issue:4 Topics: Animals; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Drug Design; Drugs, Chinese Herbal; G2 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; Liver Neoplasms; M Phase Cell Cycle Checkpoints; Mice; Mice, Nude; Podophyllotoxin; Transplantation, Heterologous	2016
Cytotoxic activity of a synthetic deoxypodophyllotoxin derivative with an opened D-ring. Journal of Asian natural products research, 2016, Volume: 18, Issue:5 Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Etoposide; HEK293 Cells; HeLa Cells; Humans; Inhibitory Concentration 50; Microtubules; Molecular Structure; Podophyllotoxin; Tubulin	2016
Interspecies differences in metabolism of deoxypodophyllotoxin in hepatic microsomes from human, monkey, rat, mouse and dog. Drug metabolism and pharmacokinetics, 2016, Volume: 31, Issue:4 Topics: Animals; Cytochrome P-450 Enzyme System; Dogs; Drugs, Chinese Herbal; Humans; Isoenzymes; Kinetics; Macaca fascicularis; Male; Mice; Microsomes, Liver; Podophyllotoxin; Rats; Rats, Sprague-Dawley; Species Specificity	2016
Antitumor effect of Deoxypodophyllotoxin on human breast cancer xenograft transplanted in BALB/c nude mice model. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2016, Volume: 22, Issue:10 Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Intravenous; Animals; Antineoplastic Agents, Phytogenic; beta-Cyclodextrins; Breast Neoplasms; Cell Line, Tumor; Docetaxel; Drugs, Chinese Herbal; Etoposide; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Podophyllotoxin; Taxoids; Xenograft Model Antitumor Assays	2016
Investigation of the Lignan Content in Extracts from Linum, Callitris and Juniperus Species in Relation to Their In Vitro Antiproliferative Activities. Planta medica, 2017, Volume: 83, Issue:6 Topics: Antineoplastic Agents; Biosynthetic Pathways; Cell Line, Tumor; Cell Proliferation; Cupressaceae; Drug Synergism; Drugs, Chinese Herbal; Flax; Humans; Juniperus; Lignans; Molecular Structure; Plant Extracts; Podophyllotoxin	2017
Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4β-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin. ACS chemical biology, 2017, 03-17, Volume: 12, Issue:3 Topics: Antineoplastic Agents; Drugs, Chinese Herbal; Microtubules; Podophyllotoxin; Polymerization; Protein Conformation; Thermodynamics; Tubulin	2017
Investigation of the anti-angiogenesis effects induced by deoxypodophyllotoxin-5-FU conjugate C069 against HUVE cells. Bioorganic & medicinal chemistry letters, 2017, 02-15, Volume: 27, Issue:4 Topics: Angiogenesis Inhibitors; beta Catenin; Cell Movement; Cell Proliferation; Cell Survival; Down-Regulation; Drugs, Chinese Herbal; Etoposide; Fluorouracil; Human Umbilical Vein Endothelial Cells; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neovascularization, Physiologic; Phosphorylation; Podophyllotoxin; Proto-Oncogene Proteins c-akt	2017
Deoxypodophyllotoxin induces cytoprotective autophagy against apoptosis via inhibition of PI3K/AKT/mTOR pathway in osteosarcoma U2OS cells. Pharmacological reports : PR, 2017, Volume: 69, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Drugs, Chinese Herbal; Gene Expression Regulation; Humans; Osteosarcoma; Phosphoinositide-3 Kinase Inhibitors; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; TOR Serine-Threonine Kinases	2017
Electrostatic interactions between polyglutamic acid and polylysine yields stable polyion complex micelles for deoxypodophyllotoxin delivery. International journal of nanomedicine, 2017, Volume: 12 Topics: Animals; Drug Carriers; Drug Liberation; Drugs, Chinese Herbal; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Micelles; Molecular Weight; Particle Size; Podophyllotoxin; Polyesters; Polyethylene Glycols; Polyglutamic Acid; Polylysine; Proton Magnetic Resonance Spectroscopy; Rabbits; Rats, Sprague-Dawley; Static Electricity; Temperature	2017
Synthesis and Computational Studies Demonstrate the Utility of an Intramolecular Styryl Diels-Alder Reaction and Di-t-butylhydroxytoluene Assisted [1,3]-Shift to Construct Anticancer dl-Deoxypodophyllotoxin. The Journal of organic chemistry, 2018, 02-16, Volume: 83, Issue:4 Topics: Antineoplastic Agents; Butylated Hydroxytoluene; Cycloaddition Reaction; Drugs, Chinese Herbal; Molecular Structure; Podophyllotoxin; Quantum Theory; Stereoisomerism; Styrene	2018
A Promising Microtubule Inhibitor Deoxypodophyllotoxin Exhibits Better Efficacy to Multidrug-Resistant Breast Cancer than Paclitaxel via Avoiding Efflux Transport. Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:5 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Female; G2 Phase Cell Cycle Checkpoints; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubules; Neoplasm Proteins; Paclitaxel; Podophyllotoxin	2018
Effect of in vitro morphogenesis on the production of podophyllotoxin derivatives in callus cultures of Linum album. Journal of plant physiology, 2018, Volume: 228 Topics: Cells, Cultured; Drugs, Chinese Herbal; Flax; Morphogenesis; Plant Shoots; Podophyllotoxin	2018
Optimization and characterization of deoxypodophyllotoxin loaded mPEG-PDLLA micelles by central composite design with response surface methodology. Chinese journal of natural medicines, 2018, Volume: 16, Issue:6 Topics: Antineoplastic Agents; Cell Survival; Drug Carriers; Drug Delivery Systems; Drug Design; Drugs, Chinese Herbal; HeLa Cells; Humans; Micelles; Particle Size; Podophyllotoxin; Polyesters; Polyethylene Glycols; Solubility; Surface Properties	2018
Deoxypodophyllotoxin in Anthriscus sylvestris alleviates fat accumulation in the liver via AMP-activated protein kinase, impeding SREBP-1c signal. Chemico-biological interactions, 2018, Oct-01, Volume: 294 Topics: AMP-Activated Protein Kinases; Animals; Apiaceae; Body Weight; Cholesterol; Diet, High-Fat; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Hydrocarbons, Fluorinated; Lipid Metabolism; Liver; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Podophyllotoxin; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Sulfonamides; Triglycerides; Up-Regulation	2018
Deoxypodophyllotoxin inhibits cell viability and invasion by blocking the PI3K/Akt signaling pathway in human glioblastoma cells. Oncology reports, 2019, Volume: 41, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Astrocytes; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Sequiviridae; Signal Transduction	2019
Deoxypodophyllotoxin Exerts Anti-Cancer Effects on Colorectal Cancer Cells Through Induction of Apoptosis and Suppression of Tumorigenesis. International journal of molecular sciences, 2019, May-28, Volume: 20, Issue:11 Topics: Animals; Antineoplastic Agents; Apoptosis; Caco-2 Cells; Carcinogenesis; Colorectal Neoplasms; Drugs, Chinese Herbal; HT29 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Microtubules; Podophyllotoxin; Tubulin Modulators	2019
Potential anti-neuroblastoma agents from Juniperus oblonga. Biochemical and biophysical research communications, 2019, 08-27, Volume: 516, Issue:3 Topics: Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Survival; Child, Preschool; Diterpenes; Drugs, Chinese Herbal; Furans; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Inhibitory Concentration 50; Juniperus; Lignans; Molecular Structure; N-Myc Proto-Oncogene Protein; Neuroblastoma; Phytotherapy; Plant Extracts; Podophyllotoxin; Tetrahydronaphthalenes	2019
Highly loaded deoxypodophyllotoxin nano-formulation delivered by methoxy polyethylene glycol-block-poly (D,L-lactide) micelles for efficient cancer therapy. Drug delivery, 2020, Volume: 27, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Delivery Systems; Drugs, Chinese Herbal; Freeze Drying; Humans; Male; Mice; Mice, Nude; Micelles; Nanoparticles; Neoplasms; Particle Size; Podophyllotoxin; Polyesters; Polyethylene Glycols; Time Factors; Tissue Distribution	2020
Derivatives of Deoxypodophyllotoxin Induce Apoptosis through Bcl-2/Bax Proteins Expression. Anti-cancer agents in medicinal chemistry, 2021, Volume: 21, Issue:5 Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Molecular Structure; Podophyllotoxin; Proto-Oncogene Proteins c-bcl-2; Structure-Activity Relationship; Tumor Cells, Cultured	2021
Deoxypodophyllotoxin, a Lignan from International journal of molecular sciences, 2020, Sep-18, Volume: 21, Issue:18 Topics: Antineoplastic Agents, Phytogenic; Apiaceae; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drugs, Chinese Herbal; ErbB Receptors; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Extracellular Signal-Regulated MAP Kinases; Humans; Lignans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species	2020
Deoxypodophyllotoxin Inhibits Cell Growth and Induces Apoptosis by Blocking EGFR and MET in Gefitinib-Resistant Non-Small Cell Lung Cancer. Journal of microbiology and biotechnology, 2021, Apr-28, Volume: 31, Issue:4 Topics: Antineoplastic Agents; Apiaceae; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Podophyllotoxin; Proto-Oncogene Proteins c-met; Signal Transduction	2021
Synthesis of (-)-deoxypodophyllotoxin and (-)-epipodophyllotoxin via a multi-enzyme cascade in E. coli. Microbial cell factories, 2021, Sep-20, Volume: 20, Issue:1 Topics: Biocatalysis; Biotransformation; Drugs, Chinese Herbal; Escherichia coli; Lignans; Podophyllotoxin	2021
Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase. Proceedings of the National Academy of Sciences of the United States of America, 2022, 01-04, Volume: 119, Issue:1 Topics: Berberidaceae; Drugs, Chinese Herbal; Ligases; Oxidation-Reduction; Plant Proteins; Podophyllotoxin	2022
Deoxypodophyllotoxin Induces ROS-Mediated Apoptosis by Modulating the PI3K/AKT and p38 MAPK-Dependent Signaling in Oral Squamous Cell Carcinoma. Journal of microbiology and biotechnology, 2022, Sep-28, Volume: 32, Issue:9 Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Drugs, Chinese Herbal; Flavonolignans; Head and Neck Neoplasms; Humans; Mouth Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Squamous Cell Carcinoma of Head and Neck	2022