Page last updated: 2024-08-22

pn 401 and uridine

pn 401 has been researched along with uridine in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.70)18.7374
1990's1 (2.70)18.2507
2000's11 (29.73)29.6817
2010's20 (54.05)24.3611
2020's4 (10.81)2.80

Authors

AuthorsStudies
Ho, IK; Kimura, T; Tateoka, Y; Watanabe, K; Yamamoto, I1
Bertino, J; Kelsen, DP; Martin, D; O'Neil, J; Saltz, L; Schwartz, G; Sung, MT; von Borstel, R1
Campbell, E; Davidson, K; Diab, SG; Drengler, RL; Eckhardt, SG; Garner, AM; Hammond, LA; Hidalgo, M; Louie, A; O'Neil, JD; Rodriguez, G; Rowinsky, EK; Villalona-Calero, MA; von Borstel, R; Von Hoff, DD; Weiss, G1
Al Safarjalani, ON; Ashour, OM; el Kouni, MH; Naguib, FN; Panzica, RP1
Ashour, OM; el Kouni, MH; Goudgaon, NM; Naguib, FN; Schinazi, RF1
Garcia, RA; Hu, Z; Li, D; Liu, LS; Saydoff, JA; von Borstel, RW1
Beal, MF; Browne, SE; Calingasan, NY; Gardian, G; Klivenyi, P; Saydoff, J; von Borstel, R; Yang, L1
Saif, MW; von Borstel, R1
Garcia, RA; Gonzalez, A; Hu, Z; Liu, L; Saydoff, JA; von Borstel, RW1
Kemeny, NE; Leonard, GD1
Abbruzzese, JL; Cobb, PW; Doroshow, JH; Issell, BF; Macdonald, JS; McCoy, S; Patel, T; Yost, KJ1
Beal, MF; Brenneman, D; Browne, SE; Burr, H; Cardin, S; Garcia, RA; Gonzalez, A; Gregorio, J; Hu, Z; Liu, L; Saydoff, JA; Sheng, J; von Borstel, RW1
Bolo, NR; Cohen, BM; Daniels, M; Haws, C; Jensen, JE; Lyoo, IK; Renshaw, PF; Rusche, JR; Stoll, AL; Yoon, SJ1
Cheung, P; Jacob, P; Mulligan, K; Roman, MC; Schambelan, M; Walker, UA; Weinberg, ME; Wen, M1
Ferreira, ML; Gudiño, ED; Iglesias, LE1
Garcia, R; Hu, Z; Li, Q; Olariu, A; Pei, J; Saydoff, JA; Sheng, J; Sun, GY; von Borstel, R1
Traynor, K1
Diasio, RB; Saif, MW1
Bai, G; Beaver, JA; Charlab, R; Chen, XH; Cheng, J; Dinin, J; Dorff, SE; Ibrahim, A; Ison, G; Jin, R; Kim, G; Liu, Q; Marathe, A; McGuinn, WD; McKee, AE; Palmby, TR; Pazdur, R; Pierce, W; Sridhara, R; Stephens, O; Tang, S; Wang, Y; Ysern, X1
Bamat, MK; Cartwright, TH; El-Rayes, BF; Fakih, MG; King, TR; Ma, WW; Posey, JA; Saif, MW; von Borstel, RW1
Wilkinson, E1
Galuski, K; Gil, B; Nugent, FW; Vaudo, CE; Zarwan, C1
Geller, RJ; Morgan, BW; Santos, C1
Hall, AJ; Holdsworth, CI; Lettieri, S; Lim, KF1
Duffy, AP; Hausner, PF; Oliver, WD1
Hu, EH; Keung, YK; Yu, D; Zurayk, M1
Aglietta, M; Bonzano, A; Cagnazzo, C; Depetris, I; Filippi, R; Leone, F; Marino, D1
Bamat, MK; Garcia, RAG; Saydoff, JA; von Borstel, RW1
Brutcher, E; Christensen, D; Hennessey Smith, M; Koutlas, JB; Sellers, JB; Thompson, J; Timmons, T1
Berrío Escobar, JF; Castelli, F; Giordani, C; Márquez Fernández, DM; Sarpietro, MG1
Robert, J1
Amylidi, AL; Angelaki, A; Aravantinos, G; Boumpoucheropoulos, S; Fildissis, G; Lampropoulou, DI; Laschos, K; Nanou, E; Nasioulas, G; Papadopoulou, E; Soupos, N; Zidianakis, V1
Badea, A; Garcia, E; Gintjee, TJ; Goodnough, R; Li, K; Lynch, KL; Repplinger, D1
Ali, S; Bui, J; Frederick, A; Garg, A; Haas, R; Nguyen, L; Sahagian, M; Sherer, K1
Leung, M; Rogers, JE; Shureiqi, I1

Reviews

6 review(s) available for pn 401 and uridine

ArticleYear
FDA Approval: Uridine Triacetate for the Treatment of Patients Following Fluorouracil or Capecitabine Overdose or Exhibiting Early-Onset Severe Toxicities Following Administration of These Drugs.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Sep-15, Volume: 22, Issue:18

    Topics: Acetates; Animals; Antineoplastic Agents; Capecitabine; Clinical Trials as Topic; Drug Approval; Drug Evaluation, Preclinical; Fluorouracil; Humans; Neoplasms; Prescription Drug Overuse; Research Design; Treatment Outcome; United States; United States Food and Drug Administration; Uridine

2016
Successful use of uridine triacetate (Vistogard) three weeks after capecitabine in a patient with homozygous dihydropyrimidine dehydrogenase mutation: A case report and review of the literature.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2019, Volume: 25, Issue:1

    Topics: Acetates; Antidotes; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Female; Humans; Middle Aged; Mutation; Uridine

2019
Fluoropyrimidine-induced cardiotoxicity.
    Critical reviews in oncology/hematology, 2018, Volume: 124

    Topics: Acetates; Capecitabine; Cardiotoxicity; Cardiovascular Diseases; Drug Combinations; Fluorouracil; Humans; Neoplasms; Pyrimidines; Pyrrolidines; Quinazolines; Thiophenes; Thymine; Trifluridine; Uracil; Uridine

2018
5-Fluorouracil and Capecitabine: Assessment and Treatment of Uncommon Early-Onset Severe Toxicities Associated With Administration.
    Clinical journal of oncology nursing, 2018, 12-01, Volume: 22, Issue:6

    Topics: Acetates; Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Patient Safety; Risk Assessment; Severity of Illness Index; Survival Analysis; Uridine

2018
Fluoropyrimidine-induced toxicity and DPD deficiency.. A case report of early onset, lethal capecitabine-induced toxicity and mini review of the literature. Uridine triacetate: Efficacy and safety as an antidote. Is it accessible outside USA?
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2020, Volume: 26, Issue:3

    Topics: Acetates; Aged; Antidotes; Antimetabolites, Antineoplastic; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Female; Humans; Neoplasms; Uridine

2020
Triacetyluridine treats epileptic encephalopathy from CAD mutations: a case report and review.
    Annals of clinical and translational neurology, 2021, Volume: 8, Issue:1

    Topics: Acetates; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Child; Dihydroorotase; Epilepsy, Generalized; Female; Humans; Mutation, Missense; Uridine

2021

Trials

5 trial(s) available for pn 401 and uridine

ArticleYear
Phase I trial of PN401, an oral prodrug of uridine, to prevent toxicity from fluorouracil in patients with advanced cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:4

    Topics: Acetates; Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Prodrugs; Uridine

1997
Phase I and pharmacologic study of PN401 and fluorouracil in patients with advanced solid malignancies.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:1

    Topics: Acetates; Adult; Antimetabolites, Antineoplastic; Cytoprotection; Diarrhea; Dose-Response Relationship, Drug; Female; Fluorouracil; Hematologic Diseases; Humans; Male; Maximum Tolerated Dose; Neutropenia; Prodrugs; Statistics, Nonparametric; Uridine

2000
Phase II trial of PN401, 5-FU, and leucovorin in unresectable or metastatic adenocarcinoma of the stomach: a Southwest Oncology Group study.
    Investigational new drugs, 2006, Volume: 24, Issue:6

    Topics: Acetates; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Stomach Neoplasms; Survival Analysis; Uridine

2006
Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients.
    Experimental and clinical psychopharmacology, 2008, Volume: 16, Issue:3

    Topics: Acetates; Adult; Antidepressive Agents; Bipolar Disorder; Brain Chemistry; Depressive Disorder; Female; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitochondria; Neuropsychological Tests; Phosphocreatine; Psychiatric Status Rating Scales; Uridine

2008
Enhanced uridine bioavailability following administration of a triacetyluridine-rich nutritional supplement.
    PloS one, 2011, Feb-17, Volume: 6, Issue:2

    Topics: Acetates; Adult; Biological Availability; Dietary Supplements; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Male; Middle Aged; Models, Biological; Osmolar Concentration; Up-Regulation; Uridine; Young Adult

2011

Other Studies

26 other study(ies) available for pn 401 and uridine

ArticleYear
N-substituted oxopyrimidines and nucleosides: structure-activity relationship for hypnotic activity as central nervous system depressant.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:12

    Topics: Animals; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Male; Mice; Phenobarbital; Sleep; Structure-Activity Relationship; Uridine

1987
Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine.
    Biochemical pharmacology, 2000, Aug-01, Volume: 60, Issue:3

    Topics: Acetates; Animals; Antimetabolites, Antineoplastic; Barbiturates; Drug Interactions; Enzyme Inhibitors; Female; Fluorouracil; Humans; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Prodrugs; Tumor Cells, Cultured; Uridine; Uridine Phosphorylase

2000
Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2',3',5'-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy.
    Cancer chemotherapy and pharmacology, 2000, Volume: 46, Issue:3

    Topics: Acetates; Animals; Biological Availability; Drug Synergism; Enzyme Inhibitors; Female; Mice; Organoselenium Compounds; Prodrugs; Uracil; Uridine; Uridine Phosphorylase

2000
Oral uridine pro-drug PN401 decreases neurodegeneration, behavioral impairment, weight loss and mortality in the 3-nitropropionic acid mitochondrial toxin model of Huntington's disease.
    Brain research, 2003, Dec-19, Volume: 994, Issue:1

    Topics: Acetates; Administration, Oral; Animals; Huntington Disease; Male; Mice; Mitochondria; Motor Activity; Nerve Degeneration; Nitro Compounds; Prodrugs; Propionates; Uridine; Weight Loss

2003
Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity.
    Neuromolecular medicine, 2004, Volume: 6, Issue:2-3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Acetates; Animals; Dietary Supplements; Disease Models, Animal; Dopamine; Homovanillic Acid; Mice; MPTP Poisoning; Neuroprotective Agents; Neurotoxins; Uridine

2004
5-Fluorouracil dose escalation enabled with PN401 (triacetyluridine): toxicity reduction and increased antitumor activity in mice.
    Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:1

    Topics: Acetates; Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Survival Rate; Tumor Burden; Uridine; Xenograft Model Antitumor Assays

2006
Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency; neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine.
    Brain research, 2005, Dec-20, Volume: 1066, Issue:1-2

    Topics: Acetates; Animals; Apoptosis; Aspartic Acid; Azides; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Complex IV; Enzyme Inhibitors; Fibroblasts; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neuroprotective Agents; Phosphonoacetic Acid; Prodrugs; Pyrimidines; Uridine

2005
Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: report of two cases.
    Diseases of the colon and rectum, 2006, Volume: 49, Issue:3

    Topics: Acetates; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Immunologic Factors; Leucovorin; Liver Neoplasms; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Remission Induction; Uridine; Vitamin B Complex

2006
Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease.
    Neurobiology of disease, 2006, Volume: 24, Issue:3

    Topics: Acetates; Administration, Oral; Analysis of Variance; Animals; Cerebral Cortex; Disease Models, Animal; Female; Huntingtin Protein; Huntington Disease; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mice, Transgenic; Motor Activity; Neostriatum; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Nuclear Proteins; Prodrugs; Rotarod Performance Test; Uridine

2006
A rational approach to the regioselective deacetylation of 2',3',5'-tri-O-acetyluridine by Novozym 435 catalysed alcoholysis.
    Biochimica et biophysica acta, 2012, Volume: 1824, Issue:4

    Topics: Acetates; Acetylation; Amino Acid Motifs; Biocatalysis; Candida; Catalytic Domain; Computer Simulation; Enzymes, Immobilized; Ethanol; Fungal Proteins; Hydrogen Bonding; Hydrolysis; Kinetics; Lipase; Models, Molecular; Protein Binding; Uridine; Water

2012
Uridine prodrug improves memory in Tg2576 and TAPP mice and reduces pathological factors associated with Alzheimer's disease in related models.
    Journal of Alzheimer's disease : JAD, 2013, Volume: 36, Issue:4

    Topics: Acetates; Alzheimer Disease; Animals; Cell Line, Tumor; Cricetinae; Disease Models, Animal; Female; Gerbillinae; Humans; Male; Maze Learning; Memory; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Prodrugs; Stroke; Uridine

2013
FDA approves therapy to treat overdose of fluorouracil, capecitabine.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2016, Feb-01, Volume: 73, Issue:3

    Topics: Acetates; Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Chemistry, Pharmaceutical; Drug Approval; Drug Overdose; Fluorouracil; Humans; United States; United States Food and Drug Administration; Uridine

2016
In brief: Uridine triacetate (Xuriden) for hereditary orotic aciduria.
    The Medical letter on drugs and therapeutics, 2016, Mar-28, Volume: 58, Issue:1491

    Topics: Acetates; Administration, Oral; Biomarkers; Drug Costs; Humans; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Purine-Pyrimidine Metabolism, Inborn Errors; Treatment Outcome; Uridine

2016
Benefit of uridine triacetate (Vistogard) in rescuing severe 5-fluorouracil toxicity in patients with dihydropyrimidine dehydrogenase (DPYD) deficiency.
    Cancer chemotherapy and pharmacology, 2016, Volume: 78, Issue:1

    Topics: Acetates; Aged; Antidotes; Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Humans; Male; Pancreatic Neoplasms; Severity of Illness Index; Time Factors; Uridine

2016
In brief: uridine triacetate (Vistogard) for fluorouracil overdose.
    The Medical letter on drugs and therapeutics, 2016, Jul-04, Volume: 58, Issue:1498

    Topics: Acetates; Antidotes; Antimetabolites, Antineoplastic; Drug Overdose; Fluorouracil; Humans; Treatment Outcome; Uridine

2016
Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity.
    Cancer, 2017, 01-01, Volume: 123, Issue:2

    Topics: Acetates; Antimetabolites, Antineoplastic; Capecitabine; Drug Overdose; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Uridine

2017
An antidote to fluorouracil and capecitabine toxicity.
    The Lancet. Oncology, 2016, Volume: 17, Issue:10

    Topics: Acetates; Antidotes; Antineoplastic Agents; Capecitabine; Drug Costs; Drug Overdose; Fluorouracil; Humans; Treatment Outcome; Uridine

2016
Early-Onset 5-Fluorouracil Toxicity in a Patient Negative for Dihydropyrimidine Dehydrogenase Mutations: The Clinical Course of Reversal with Uridine Triacetate.
    Pharmacotherapy, 2016, Volume: 36, Issue:11

    Topics: Acetates; Aged; Antidotes; Antimetabolites, Antineoplastic; Anus Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fatigue; Fluorouracil; Follow-Up Studies; Humans; Male; Mucositis; Mutation; Neutrophils; Time Factors; Uridine

2016
The successful treatment of 5-fluorouracil (5-FU) overdose in a patient with malignancy and HIV/AIDS with uridine triacetate.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:5

    Topics: Acetates; Antimetabolites, Antineoplastic; Anus Neoplasms; Depression; Drug Overdose; Emergency Medicine; Fluorouracil; HIV Infections; Humans; Male; Middle Aged; Toxoplasmosis, Cerebral; Treatment Outcome; Uridine

2017
Assessment of the imprinting efficiency of an imide with a "stoichiometric" pyridine-based functional monomer in precipitation polymerisation.
    Journal of molecular recognition : JMR, 2018, Volume: 31, Issue:3

    Topics: Acetates; Hydrogen Bonding; Imides; Macromolecular Substances; Molecular Imprinting; Polymerization; Polymers; Pyridines; Uridine

2018
Case report of capecitabine toxicity and use of uridine triacetate.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2019, Volume: 25, Issue:2

    Topics: Acetates; Aged; Antimetabolites, Antineoplastic; Capecitabine; Diarrhea; Drug Eruptions; Fatal Outcome; Humans; Liver Neoplasms; Male; Mucositis; Uridine

2019
Prompt treatment with uridine triacetate improves survival and reduces toxicity due to fluorouracil and capecitabine overdose or dihydropyrimidine dehydrogenase deficiency.
    Toxicology and applied pharmacology, 2018, 08-15, Volume: 353

    Topics: Acetates; Animals; Antidotes; Antimetabolites, Antineoplastic; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Dose-Response Relationship, Drug; Drug Overdose; Female; Fluorouracil; Mice; Survival Analysis; Uridine

2018
Anomalous interaction of tri-acyl ester derivatives of uridine nucleoside with a l-α-dimyristoylphosphatidylcholine biomembrane model: a differential scanning calorimetry study.
    The Journal of pharmacy and pharmacology, 2019, Volume: 71, Issue:3

    Topics: Acetates; Calorimetry, Differential Scanning; Dimyristoylphosphatidylcholine; Esters; Fatty Acids; Membranes; Models, Theoretical; Nucleosides; Phospholipids; Uridine

2019
[5-FU: At last!]
    Bulletin du cancer, 2019, Volume: 106, Issue:3

    Topics: Acetates; Antidotes; Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Fluorouracil; Humans; Neoplasms; Practice Guidelines as Topic; Pyrimidines; Uracil; Uridine

2019
Real-time comprehensive toxicology testing in the clinical management of accidental pediatric capecitabine ingestion.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2020, Volume: 26, Issue:7

    Topics: Acetates; Antidotes; Antimetabolites, Antineoplastic; Capecitabine; Child, Preschool; Humans; Male; Uridine

2020
Use of Uridine Triacetate to Reverse Severe Persistent Myelosuppression Following 5-fluorouracil Exposure in a Patient With a c.557A>G Heterozygous DPYD Variant.
    Clinical colorectal cancer, 2021, Volume: 20, Issue:3

    Topics: Acetates; Fluorouracil; Humans; Neoplasms; Uridine

2021