pn 401 has been researched along with uridine in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.70) | 18.7374 |
| 1990's | 1 (2.70) | 18.2507 |
| 2000's | 11 (29.73) | 29.6817 |
| 2010's | 20 (54.05) | 24.3611 |
| 2020's | 4 (10.81) | 2.80 |
| Authors | Studies |
|---|---|
| Ho, IK; Kimura, T; Tateoka, Y; Watanabe, K; Yamamoto, I | 1 |
| Bertino, J; Kelsen, DP; Martin, D; O'Neil, J; Saltz, L; Schwartz, G; Sung, MT; von Borstel, R | 1 |
| Campbell, E; Davidson, K; Diab, SG; Drengler, RL; Eckhardt, SG; Garner, AM; Hammond, LA; Hidalgo, M; Louie, A; O'Neil, JD; Rodriguez, G; Rowinsky, EK; Villalona-Calero, MA; von Borstel, R; Von Hoff, DD; Weiss, G | 1 |
| Al Safarjalani, ON; Ashour, OM; el Kouni, MH; Naguib, FN; Panzica, RP | 1 |
| Ashour, OM; el Kouni, MH; Goudgaon, NM; Naguib, FN; Schinazi, RF | 1 |
| Garcia, RA; Hu, Z; Li, D; Liu, LS; Saydoff, JA; von Borstel, RW | 1 |
| Beal, MF; Browne, SE; Calingasan, NY; Gardian, G; Klivenyi, P; Saydoff, J; von Borstel, R; Yang, L | 1 |
| Saif, MW; von Borstel, R | 1 |
| Garcia, RA; Gonzalez, A; Hu, Z; Liu, L; Saydoff, JA; von Borstel, RW | 1 |
| Kemeny, NE; Leonard, GD | 1 |
| Abbruzzese, JL; Cobb, PW; Doroshow, JH; Issell, BF; Macdonald, JS; McCoy, S; Patel, T; Yost, KJ | 1 |
| Beal, MF; Brenneman, D; Browne, SE; Burr, H; Cardin, S; Garcia, RA; Gonzalez, A; Gregorio, J; Hu, Z; Liu, L; Saydoff, JA; Sheng, J; von Borstel, RW | 1 |
| Bolo, NR; Cohen, BM; Daniels, M; Haws, C; Jensen, JE; Lyoo, IK; Renshaw, PF; Rusche, JR; Stoll, AL; Yoon, SJ | 1 |
| Cheung, P; Jacob, P; Mulligan, K; Roman, MC; Schambelan, M; Walker, UA; Weinberg, ME; Wen, M | 1 |
| Ferreira, ML; Gudiño, ED; Iglesias, LE | 1 |
| Garcia, R; Hu, Z; Li, Q; Olariu, A; Pei, J; Saydoff, JA; Sheng, J; Sun, GY; von Borstel, R | 1 |
| Traynor, K | 1 |
| Diasio, RB; Saif, MW | 1 |
| Bai, G; Beaver, JA; Charlab, R; Chen, XH; Cheng, J; Dinin, J; Dorff, SE; Ibrahim, A; Ison, G; Jin, R; Kim, G; Liu, Q; Marathe, A; McGuinn, WD; McKee, AE; Palmby, TR; Pazdur, R; Pierce, W; Sridhara, R; Stephens, O; Tang, S; Wang, Y; Ysern, X | 1 |
| Bamat, MK; Cartwright, TH; El-Rayes, BF; Fakih, MG; King, TR; Ma, WW; Posey, JA; Saif, MW; von Borstel, RW | 1 |
| Wilkinson, E | 1 |
| Galuski, K; Gil, B; Nugent, FW; Vaudo, CE; Zarwan, C | 1 |
| Geller, RJ; Morgan, BW; Santos, C | 1 |
| Hall, AJ; Holdsworth, CI; Lettieri, S; Lim, KF | 1 |
| Duffy, AP; Hausner, PF; Oliver, WD | 1 |
| Hu, EH; Keung, YK; Yu, D; Zurayk, M | 1 |
| Aglietta, M; Bonzano, A; Cagnazzo, C; Depetris, I; Filippi, R; Leone, F; Marino, D | 1 |
| Bamat, MK; Garcia, RAG; Saydoff, JA; von Borstel, RW | 1 |
| Brutcher, E; Christensen, D; Hennessey Smith, M; Koutlas, JB; Sellers, JB; Thompson, J; Timmons, T | 1 |
| Berrío Escobar, JF; Castelli, F; Giordani, C; Márquez Fernández, DM; Sarpietro, MG | 1 |
| Robert, J | 1 |
| Amylidi, AL; Angelaki, A; Aravantinos, G; Boumpoucheropoulos, S; Fildissis, G; Lampropoulou, DI; Laschos, K; Nanou, E; Nasioulas, G; Papadopoulou, E; Soupos, N; Zidianakis, V | 1 |
| Badea, A; Garcia, E; Gintjee, TJ; Goodnough, R; Li, K; Lynch, KL; Repplinger, D | 1 |
| Ali, S; Bui, J; Frederick, A; Garg, A; Haas, R; Nguyen, L; Sahagian, M; Sherer, K | 1 |
| Leung, M; Rogers, JE; Shureiqi, I | 1 |
6 review(s) available for pn 401 and uridine
| Article | Year |
|---|---|
FDA Approval: Uridine Triacetate for the Treatment of Patients Following Fluorouracil or Capecitabine Overdose or Exhibiting Early-Onset Severe Toxicities Following Administration of These Drugs.
Topics: Acetates; Animals; Antineoplastic Agents; Capecitabine; Clinical Trials as Topic; Drug Approval; Drug Evaluation, Preclinical; Fluorouracil; Humans; Neoplasms; Prescription Drug Overuse; Research Design; Treatment Outcome; United States; United States Food and Drug Administration; Uridine | 2016 |
Successful use of uridine triacetate (Vistogard) three weeks after capecitabine in a patient with homozygous dihydropyrimidine dehydrogenase mutation: A case report and review of the literature.
Topics: Acetates; Antidotes; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Female; Humans; Middle Aged; Mutation; Uridine | 2019 |
Fluoropyrimidine-induced cardiotoxicity.
Topics: Acetates; Capecitabine; Cardiotoxicity; Cardiovascular Diseases; Drug Combinations; Fluorouracil; Humans; Neoplasms; Pyrimidines; Pyrrolidines; Quinazolines; Thiophenes; Thymine; Trifluridine; Uracil; Uridine | 2018 |
5-Fluorouracil and Capecitabine: Assessment and Treatment of Uncommon Early-Onset Severe Toxicities Associated With Administration.
Topics: Acetates; Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Patient Safety; Risk Assessment; Severity of Illness Index; Survival Analysis; Uridine | 2018 |
Fluoropyrimidine-induced toxicity and DPD deficiency.. A case report of early onset, lethal capecitabine-induced toxicity and mini review of the literature. Uridine triacetate: Efficacy and safety as an antidote. Is it accessible outside USA?
Topics: Acetates; Aged; Antidotes; Antimetabolites, Antineoplastic; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Female; Humans; Neoplasms; Uridine | 2020 |
Triacetyluridine treats epileptic encephalopathy from CAD mutations: a case report and review.
Topics: Acetates; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Child; Dihydroorotase; Epilepsy, Generalized; Female; Humans; Mutation, Missense; Uridine | 2021 |
5 trial(s) available for pn 401 and uridine
| Article | Year |
|---|---|
Phase I trial of PN401, an oral prodrug of uridine, to prevent toxicity from fluorouracil in patients with advanced cancer.
Topics: Acetates; Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Prodrugs; Uridine | 1997 |
Phase I and pharmacologic study of PN401 and fluorouracil in patients with advanced solid malignancies.
Topics: Acetates; Adult; Antimetabolites, Antineoplastic; Cytoprotection; Diarrhea; Dose-Response Relationship, Drug; Female; Fluorouracil; Hematologic Diseases; Humans; Male; Maximum Tolerated Dose; Neutropenia; Prodrugs; Statistics, Nonparametric; Uridine | 2000 |
Phase II trial of PN401, 5-FU, and leucovorin in unresectable or metastatic adenocarcinoma of the stomach: a Southwest Oncology Group study.
Topics: Acetates; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Stomach Neoplasms; Survival Analysis; Uridine | 2006 |
Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients.
Topics: Acetates; Adult; Antidepressive Agents; Bipolar Disorder; Brain Chemistry; Depressive Disorder; Female; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitochondria; Neuropsychological Tests; Phosphocreatine; Psychiatric Status Rating Scales; Uridine | 2008 |
Enhanced uridine bioavailability following administration of a triacetyluridine-rich nutritional supplement.
Topics: Acetates; Adult; Biological Availability; Dietary Supplements; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Male; Middle Aged; Models, Biological; Osmolar Concentration; Up-Regulation; Uridine; Young Adult | 2011 |
26 other study(ies) available for pn 401 and uridine
| Article | Year |
|---|---|
N-substituted oxopyrimidines and nucleosides: structure-activity relationship for hypnotic activity as central nervous system depressant.
Topics: Animals; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Male; Mice; Phenobarbital; Sleep; Structure-Activity Relationship; Uridine | 1987 |
Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine.
Topics: Acetates; Animals; Antimetabolites, Antineoplastic; Barbiturates; Drug Interactions; Enzyme Inhibitors; Female; Fluorouracil; Humans; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Prodrugs; Tumor Cells, Cultured; Uridine; Uridine Phosphorylase | 2000 |
Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2',3',5'-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy.
Topics: Acetates; Animals; Biological Availability; Drug Synergism; Enzyme Inhibitors; Female; Mice; Organoselenium Compounds; Prodrugs; Uracil; Uridine; Uridine Phosphorylase | 2000 |
Oral uridine pro-drug PN401 decreases neurodegeneration, behavioral impairment, weight loss and mortality in the 3-nitropropionic acid mitochondrial toxin model of Huntington's disease.
Topics: Acetates; Administration, Oral; Animals; Huntington Disease; Male; Mice; Mitochondria; Motor Activity; Nerve Degeneration; Nitro Compounds; Prodrugs; Propionates; Uridine; Weight Loss | 2003 |
Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Acetates; Animals; Dietary Supplements; Disease Models, Animal; Dopamine; Homovanillic Acid; Mice; MPTP Poisoning; Neuroprotective Agents; Neurotoxins; Uridine | 2004 |
5-Fluorouracil dose escalation enabled with PN401 (triacetyluridine): toxicity reduction and increased antitumor activity in mice.
Topics: Acetates; Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Survival Rate; Tumor Burden; Uridine; Xenograft Model Antitumor Assays | 2006 |
Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency; neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine.
Topics: Acetates; Animals; Apoptosis; Aspartic Acid; Azides; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Complex IV; Enzyme Inhibitors; Fibroblasts; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neuroprotective Agents; Phosphonoacetic Acid; Prodrugs; Pyrimidines; Uridine | 2005 |
Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: report of two cases.
Topics: Acetates; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Immunologic Factors; Leucovorin; Liver Neoplasms; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Remission Induction; Uridine; Vitamin B Complex | 2006 |
Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease.
Topics: Acetates; Administration, Oral; Analysis of Variance; Animals; Cerebral Cortex; Disease Models, Animal; Female; Huntingtin Protein; Huntington Disease; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mice, Transgenic; Motor Activity; Neostriatum; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Nuclear Proteins; Prodrugs; Rotarod Performance Test; Uridine | 2006 |
A rational approach to the regioselective deacetylation of 2',3',5'-tri-O-acetyluridine by Novozym 435 catalysed alcoholysis.
Topics: Acetates; Acetylation; Amino Acid Motifs; Biocatalysis; Candida; Catalytic Domain; Computer Simulation; Enzymes, Immobilized; Ethanol; Fungal Proteins; Hydrogen Bonding; Hydrolysis; Kinetics; Lipase; Models, Molecular; Protein Binding; Uridine; Water | 2012 |
Uridine prodrug improves memory in Tg2576 and TAPP mice and reduces pathological factors associated with Alzheimer's disease in related models.
Topics: Acetates; Alzheimer Disease; Animals; Cell Line, Tumor; Cricetinae; Disease Models, Animal; Female; Gerbillinae; Humans; Male; Maze Learning; Memory; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Prodrugs; Stroke; Uridine | 2013 |
FDA approves therapy to treat overdose of fluorouracil, capecitabine.
Topics: Acetates; Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Chemistry, Pharmaceutical; Drug Approval; Drug Overdose; Fluorouracil; Humans; United States; United States Food and Drug Administration; Uridine | 2016 |
In brief: Uridine triacetate (Xuriden) for hereditary orotic aciduria.
Topics: Acetates; Administration, Oral; Biomarkers; Drug Costs; Humans; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Purine-Pyrimidine Metabolism, Inborn Errors; Treatment Outcome; Uridine | 2016 |
Benefit of uridine triacetate (Vistogard) in rescuing severe 5-fluorouracil toxicity in patients with dihydropyrimidine dehydrogenase (DPYD) deficiency.
Topics: Acetates; Aged; Antidotes; Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Humans; Male; Pancreatic Neoplasms; Severity of Illness Index; Time Factors; Uridine | 2016 |
In brief: uridine triacetate (Vistogard) for fluorouracil overdose.
Topics: Acetates; Antidotes; Antimetabolites, Antineoplastic; Drug Overdose; Fluorouracil; Humans; Treatment Outcome; Uridine | 2016 |
Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity.
Topics: Acetates; Antimetabolites, Antineoplastic; Capecitabine; Drug Overdose; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Uridine | 2017 |
An antidote to fluorouracil and capecitabine toxicity.
Topics: Acetates; Antidotes; Antineoplastic Agents; Capecitabine; Drug Costs; Drug Overdose; Fluorouracil; Humans; Treatment Outcome; Uridine | 2016 |
Early-Onset 5-Fluorouracil Toxicity in a Patient Negative for Dihydropyrimidine Dehydrogenase Mutations: The Clinical Course of Reversal with Uridine Triacetate.
Topics: Acetates; Aged; Antidotes; Antimetabolites, Antineoplastic; Anus Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fatigue; Fluorouracil; Follow-Up Studies; Humans; Male; Mucositis; Mutation; Neutrophils; Time Factors; Uridine | 2016 |
The successful treatment of 5-fluorouracil (5-FU) overdose in a patient with malignancy and HIV/AIDS with uridine triacetate.
Topics: Acetates; Antimetabolites, Antineoplastic; Anus Neoplasms; Depression; Drug Overdose; Emergency Medicine; Fluorouracil; HIV Infections; Humans; Male; Middle Aged; Toxoplasmosis, Cerebral; Treatment Outcome; Uridine | 2017 |
Assessment of the imprinting efficiency of an imide with a "stoichiometric" pyridine-based functional monomer in precipitation polymerisation.
Topics: Acetates; Hydrogen Bonding; Imides; Macromolecular Substances; Molecular Imprinting; Polymerization; Polymers; Pyridines; Uridine | 2018 |
Case report of capecitabine toxicity and use of uridine triacetate.
Topics: Acetates; Aged; Antimetabolites, Antineoplastic; Capecitabine; Diarrhea; Drug Eruptions; Fatal Outcome; Humans; Liver Neoplasms; Male; Mucositis; Uridine | 2019 |
Prompt treatment with uridine triacetate improves survival and reduces toxicity due to fluorouracil and capecitabine overdose or dihydropyrimidine dehydrogenase deficiency.
Topics: Acetates; Animals; Antidotes; Antimetabolites, Antineoplastic; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Dose-Response Relationship, Drug; Drug Overdose; Female; Fluorouracil; Mice; Survival Analysis; Uridine | 2018 |
Anomalous interaction of tri-acyl ester derivatives of uridine nucleoside with a l-α-dimyristoylphosphatidylcholine biomembrane model: a differential scanning calorimetry study.
Topics: Acetates; Calorimetry, Differential Scanning; Dimyristoylphosphatidylcholine; Esters; Fatty Acids; Membranes; Models, Theoretical; Nucleosides; Phospholipids; Uridine | 2019 |
[5-FU: At last!]
Topics: Acetates; Antidotes; Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Fluorouracil; Humans; Neoplasms; Practice Guidelines as Topic; Pyrimidines; Uracil; Uridine | 2019 |
Real-time comprehensive toxicology testing in the clinical management of accidental pediatric capecitabine ingestion.
Topics: Acetates; Antidotes; Antimetabolites, Antineoplastic; Capecitabine; Child, Preschool; Humans; Male; Uridine | 2020 |
Use of Uridine Triacetate to Reverse Severe Persistent Myelosuppression Following 5-fluorouracil Exposure in a Patient With a c.557A>G Heterozygous DPYD Variant.
Topics: Acetates; Fluorouracil; Humans; Neoplasms; Uridine | 2021 |