Page last updated: 2024-08-21

plumbagin and juglone

plumbagin has been researched along with juglone in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19903 (8.33)18.7374
1990's4 (11.11)18.2507
2000's8 (22.22)29.6817
2010's18 (50.00)24.3611
2020's3 (8.33)2.80

Authors

AuthorsStudies
Divo, AA; Lin, TS; Sartorelli, AC; Xu, SP; Zhu, LY1
Assimopoulou, AN; Couladouros, EA; Li, T; Mellidis, AS; Papageorgiou, VP; Pitsinos, EN; Plyta, ZF1
Fischer, TC; Gosch, C; Gselmann, M; Mirbeth, B; Stich, K; Thallmair, V1
Bhasin, D; Chettiar, SN; Etter, JP; Li, PK; Mok, M1
Balaji, R; Dinesh, R; Kandhasamy, S; Karunagaran, D; Mathivanan, N; Mukesh, D; Perumal, PT; Shruthy, S; Shweta, S; Sreelatha, T1
Mallavadhani, UV; Naidu, VG; Prasad, CV; Shrivastava, S1
Mostert, S; Petzer, A; Petzer, JP1
Epifano, F; Fiorito, S; Genovese, S; Kiss, R; Mathieu, V; Taddeo, VA1
Epifano, F; Fiorito, S; Genovese, S; Hill, K; Leonhardt, M; Schulze, A; Taddeo, VA1
Barbosa, JMC; Bower, JF; da Silva Júnior, EN; de Castro, SL; de Simone, CA; Goulart, MOF; Jardim, GAM; Salomão, K; Silva, TL1
Abdeen, S; Chapman, E; Chitre, S; Hoang, QQ; Johnson, SM; Park, Y; Ray, AM; Salim, N; Sivinski, J; Stevens, M; Washburn, A1
Afraj, SN; Barve, BD; Ho, HO; Hung, CC; Kuo, LY; Kuo, YH; Lin, ZH; Shen, CC1
Mitchell, MJ; Smith, SL1
Inada, A; Inouye, K; Muto, N; Nakanishi, T; Tan, L1
Hassan, HM; Kao, SM1
Matthews, RS1
Kawai, K; Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Tanaka, T; Yamahara, J1
Munday, CM; Munday, R1
Fischer, G; Küllertz, G; Lu, KP; Luckner, M; Metzner, M; Rücknagel, KP; Stoller, G1
Chen, AY; LaVoie, EJ; Liu, LF; Mao, Y; Wang, H; Zhou, N1
Comandini, O; Curreli, N; Massa, L; Rinaldi, A; Rinaldi, AC; Rufo, A; Sanjust, E; Sollai, F1
Chignell, CF; Inbaraj, JJ1
de Vries, S; Heering, HA1
Cutler, HG; Cutler, SJ; Dawson, R; Orano-Dawson, CE; Wright, DA1
Frontana, C; Gómez, M; González, FJ; González, I; Hernández-Muñoz, LS1
Rajaram, A; Rajaram, R; Seshadri, P1
Banerji, A; G, R; G, S; K A, T; K C, S; Nair, RS; Somasundaram, V; Srinivas, P; T, R1
Bao, JL; Chen, XP; Huang, MQ; Lu, JJ; Wang, YT; Wu, GS; Xu, WS1
Gautam, S; Kumar, S; Sharma, A1
Kawamura, M; Kuramochi, K; Kuriyama, I; Maruo, S; Mizushina, Y; Tsubaki, K; Yoshida, H1
Biersack, B; Mahal, K; Schobert, R; Spoerlein-Guettler, C1
Adam, V; Babula, P; Jampilek, J; Pekarek, T; Vaverkova, V; Vrana, O1
Kim, SY; Lee, TH; Moon, EY; Wahedi, HM1
Margina, D; Mihai, DP; Nicorescu, IM; Nitulescu, G; Nitulescu, GM; Olaru, OT; Ungurianu, A; Zanfirescu, A1
Barnaś, K; Dziuba, J; Kapsiak, M; Nowicka, B; Suchoń, A; Walczak, J1
Benfodda, Z; Duvauchelle, V; Majdi, C; Meffre, P1

Reviews

2 review(s) available for plumbagin and juglone

ArticleYear
Quinones derived from plant secondary metabolites as anti-cancer agents.
    Anti-cancer agents in medicinal chemistry, 2013, Volume: 13, Issue:3

    Topics: Anthraquinones; Antineoplastic Agents, Phytogenic; Benzoquinones; Cell Line, Tumor; Cell Survival; Humans; Naphthoquinones; Neoplasms; Plant Extracts

2013
An overview on the antibacterial properties of juglone, naphthazarin, plumbagin and lawsone derivatives and their metal complexes.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 162

    Topics: Anti-Bacterial Agents; Bacteria; Coordination Complexes; Humans; Naphthoquinones

2023

Other Studies

34 other study(ies) available for plumbagin and juglone

ArticleYear
Synthesis and antimalarial activity of 2-aziridinyl- and 2,3-bis(aziridinyl)-1,4-naphthoquinonyl sulfonate and acylate derivatives.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:5

    Topics: Animals; Antimalarials; Aziridines; Chemical Phenomena; Chemistry; Naphthoquinones; Plasmodium falciparum; Structure-Activity Relationship

1991
Inhibition of topoisomerase I by naphthoquinone derivatives.
    Bioorganic & medicinal chemistry letters, 1998, Dec-01, Volume: 8, Issue:23

    Topics: Enzyme Inhibitors; Naphthoquinones; Structure-Activity Relationship; Topoisomerase I Inhibitors; Zinc

1998
Potent and specific bactericidal effect of juglone (5-hydroxy-1,4-naphthoquinone) on the fire blight pathogen Erwinia amylovora.
    Journal of agricultural and food chemistry, 2012, Dec-12, Volume: 60, Issue:49

    Topics: Agrochemicals; Anti-Bacterial Agents; Drug Evaluation, Preclinical; Drug Stability; Erwinia amylovora; Flowers; Germination; Hydrogen-Ion Concentration; Malus; Microbial Sensitivity Tests; Naphthoquinones; Plant Diseases; Quinones; Toxicity Tests

2012
Anticancer activity and SAR studies of substituted 1,4-naphthoquinones.
    Bioorganic & medicinal chemistry, 2013, Aug-01, Volume: 21, Issue:15

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Models, Molecular; Naphthoquinones; Structure-Activity Relationship

2013
Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives.
    Bioorganic & medicinal chemistry letters, 2014, Aug-01, Volume: 24, Issue:15

    Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Candida albicans; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Drug Screening Assays, Antitumor; Fluconazole; HeLa Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa; Structure-Activity Relationship

2014
Synthesis and anticancer activity of some novel 5,6-fused hybrids of juglone based 1,4-naphthoquinones.
    European journal of medicinal chemistry, 2014, Aug-18, Volume: 83

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Humans; Naphthoquinones

2014
Evaluation of Natural and Synthetic 1,4-naphthoquinones as Inhibitors of Monoamine Oxidase.
    Chemical biology & drug design, 2016, Volume: 87, Issue:5

    Topics: Kinetics; Molecular Docking Simulation; Monoamine Oxidase Inhibitors; Naphthoquinones; Structure-Activity Relationship

2016
Novel juglone and plumbagin 5-O derivatives and their in vitro growth inhibitory activity against apoptosis-resistant cancer cells.
    Bioorganic & medicinal chemistry letters, 2016, Jan-15, Volume: 26, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Naphthoquinones

2016
Plumbagin, Juglone, and Boropinal as Novel TRPA1 Agonists.
    Journal of natural products, 2016, Apr-22, Volume: 79, Issue:4

    Topics: Animals; Ankyrins; Calcium; Coumarins; Female; Ganglia, Spinal; HEK293 Cells; Humans; Male; Mice; Molecular Structure; Naphthoquinones; Phenylpropionates; Sensory Receptor Cells; Transient Receptor Potential Channels; TRPA1 Cation Channel

2016
Rhodium-catalyzed C-H bond activation for the synthesis of quinonoid compounds: Significant Anti-Trypanosoma cruzi activities and electrochemical studies of functionalized quinones.
    European journal of medicinal chemistry, 2017, Aug-18, Volume: 136

    Topics: Animals; Catalysis; Dose-Response Relationship, Drug; Electrochemical Techniques; Macrophages; Mice; Molecular Structure; Quinones; Rhodium; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi

2017
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.
    Bioorganic & medicinal chemistry letters, 2019, 05-01, Volume: 29, Issue:9

    Topics: Biological Products; Chaperonin 10; Chaperonin 60; Escherichia coli; Humans; Inhibitory Concentration 50; Protein Folding; Rafoxanide; Salicylanilides; Suramin

2019
Synthesis, biological evaluation, and correlation of cytotoxicity versus redox potential of 1,4-naphthoquinone derivatives.
    Bioorganic & medicinal chemistry letters, 2021, 06-01, Volume: 41

    Topics: Antineoplastic Agents; Cell Proliferation; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Humans; KB Cells; Molecular Structure; Naphthoquinones; Oxidation-Reduction; Structure-Activity Relationship; Topoisomerase I Inhibitors

2021
Effects of the chitin synthetase inhibitor plumbagin and its 2-demethyl derivative juglone on insect ecdysone 20-monooxygenase activity.
    Experientia, 1988, Dec-01, Volume: 44, Issue:11-12

    Topics: Aedes; Animals; Aryl Hydrocarbon Hydroxylases; Chitin Synthase; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drosophila melanogaster; Female; Glucosyltransferases; Larva; Lepidoptera; Moths; Naphthoquinones; Steroid Hydroxylases

1988
Inhibition of cytochrome P-450-linked monooxygenase systems by naphthoquinones.
    Biochemical and biophysical research communications, 1987, Jul-31, Volume: 146, Issue:2

    Topics: Androstenedione; Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Humans; Microsomes; Microsomes, Liver; Naphthoquinones; Oxygenases; Placenta; Rabbits; Spectrophotometry; Vitamin K

1987
Biochemical characterization of a paraquat-tolerant mutant of Escherichia coli.
    The Journal of biological chemistry, 1985, Sep-05, Volume: 260, Issue:19

    Topics: Drug Resistance, Microbial; Escherichia coli; Kinetics; Mutation; Naphthoquinones; Oxidation-Reduction; Paraquat; Pigments, Biological; Superoxide Dismutase

1985
Artemia salina as a test organism for measuring superoxide-mediated toxicity.
    Free radical biology & medicine, 1995, Volume: 18, Issue:5

    Topics: Animals; Artemia; Biological Assay; Deferoxamine; Dimethyl Sulfoxide; Drug Evaluation, Preclinical; Drug Interactions; Hydrogen Peroxide; Naphthoquinones; Paraquat; Potassium Cyanide; Reactive Oxygen Species; Sensitivity and Specificity; Superoxide Dismutase; Superoxides; Ubiquinone; Vitamin K; Vitamin K 3

1995
Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats.
    Cancer letters, 1998, May-15, Volume: 127, Issue:1-2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Azo Compounds; Benzopyrans; Colonic Neoplasms; Coumarins; Diet; Intestinal Neoplasms; Isocoumarins; Male; Naphthoquinones; Rats; Rats, Inbred F344

1998
Induction of quinone reductase and glutathione transferase in rat tissues by juglone and plumbagin.
    Planta medica, 2000, Volume: 66, Issue:5

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Female; Glutathione Transferase; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Organ Specificity; Rats; Rats, Sprague-Dawley

2000
Functional replacement of the essential ESS1 in yeast by the plant parvulin DlPar13.
    The Journal of biological chemistry, 2001, Apr-27, Volume: 276, Issue:17

    Topics: Amino Acid Sequence; Blotting, Western; Cell Nucleus; Cloning, Molecular; Cytosol; Digitalis; DNA, Complementary; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Genetic Complementation Test; Humans; Kinetics; Molecular Sequence Data; Mutation; Naphthoquinones; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phenotype; Phosphoserine; Phosphothreonine; Plant Proteins; Plants, Medicinal; Plants, Toxic; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Subcellular Fractions; Substrate Specificity; Temperature; Time Factors

2001
Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation.
    Biochemistry, 2001, Mar-20, Volume: 40, Issue:11

    Topics: Alanine; Alkylation; Animals; Cysteine; DNA Damage; DNA Topoisomerases, Type II; Drosophila; Humans; Intercalating Agents; KB Cells; Mutagenesis, Site-Directed; Naphthoquinones; Quinones; Sulfhydryl Compounds; Tumor Cells, Cultured; Vitamin K

2001
Effects of plant-derived naphthoquinones on the growth of Pleurotus sajor-caju and degradation of the compounds by fungal cultures.
    Journal of basic microbiology, 2001, Volume: 41, Issue:5

    Topics: Biodegradation, Environmental; Culture Media; Microbial Sensitivity Tests; Naphthoquinones; Plants; Pleurotus

2001
Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes.
    Chemical research in toxicology, 2004, Volume: 17, Issue:1

    Topics: Benzoquinones; Cell Line; Chromatography, High Pressure Liquid; Cytotoxins; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Glutathione; Glutathione Disulfide; Humans; Hydrogen Peroxide; Juglans; Keratinocytes; Naphthoquinones; Oxidation-Reduction; Pigments, Biological

2004
NO reductase from Bacillus azotoformans is a bifunctional enzyme accepting electrons from menaquinol and a specific endogenous membrane-bound cytochrome c551.
    Biochemistry, 2004, Oct-26, Volume: 43, Issue:42

    Topics: Amino Acid Sequence; Bacillus; Bacterial Proteins; Cytochrome c Group; Electrochemistry; Electron Transport; Intracellular Membranes; Kinetics; Membrane Proteins; Molecular Sequence Data; Multienzyme Complexes; Naphthoquinones; Nitric Oxide; Oxidation-Reduction; Oxidoreductases; Protein Subunits

2004
Screening of natural product biocides for control of non-indigenous species.
    Environmental technology, 2007, Volume: 28, Issue:3

    Topics: Animals; Biological Products; Cyprinidae; Disinfectants; Invertebrates; Larva; Molecular Structure; Naphthoquinones; Pest Control; Phaeophyceae; Quinones; Ships; Toxicity Tests; Vitamin K 3

2007
Towards a molecular-level understanding of the reactivity differences for radical anions of juglone and plumbagin: an electrochemical and spectroelectrochemical approach.
    Organic & biomolecular chemistry, 2009, May-07, Volume: 7, Issue:9

    Topics: Anions; Dimethyl Sulfoxide; Electrochemical Techniques; Electron Spin Resonance Spectroscopy; Free Radicals; Molecular Structure; Naphthoquinones; Oxidation-Reduction

2009
Plumbagin and juglone induce caspase-3-dependent apoptosis involving the mitochondria through ROS generation in human peripheral blood lymphocytes.
    Free radical biology & medicine, 2011, Dec-01, Volume: 51, Issue:11

    Topics: Adult; Apoptosis; Caspase 3; Caspase Inhibitors; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Leukocytes, Mononuclear; Mitochondria; Naphthoquinones; Oligopeptides; Reactive Oxygen Species; Reference Values; Time Factors

2011
Structure activity relationship of plumbagin in BRCA1 related cancer cells.
    Molecular carcinogenesis, 2013, Volume: 52, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; BRCA1 Protein; Breast Neoplasms; Cell Cycle Checkpoints; Drug Screening Assays, Antitumor; Estrogen Receptor alpha; Female; Gene Knockout Techniques; Humans; Membrane Potential, Mitochondrial; Molecular Docking Simulation; Naphthoquinones; Ovarian Neoplasms; Poly(ADP-ribose) Polymerases; Response Elements; Structure-Activity Relationship; Transcriptome

2013
Antimutagenic and antioxidant properties of plumbagin and other naphthoquinones.
    Mutation research, 2013, Jul-04, Volume: 755, Issue:1

    Topics: Anticoagulants; Antifibrinolytic Agents; Antimutagenic Agents; Antineoplastic Agents; Antioxidants; Drug Resistance, Bacterial; Escherichia coli; Molecular Structure; Naphthoquinones; Nucleic Acid Synthesis Inhibitors; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Rifampin; Salmonella typhimurium; Structure-Activity Relationship; Vitamin K 3

2013
Anti-tumor effects of novel 5-O-acyl plumbagins based on the inhibition of mammalian DNA replicative polymerase activity.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; DNA; DNA Replication; DNA-Directed DNA Polymerase; HCT116 Cells; HT29 Cells; Humans; Lethal Dose 50; Male; Mammals; Mice; Mice, Inbred BALB C; Mice, Nude; Naphthoquinones; Nucleic Acid Synthesis Inhibitors; Temperature

2014
Ferrocene and (arene)ruthenium(II) complexes of the natural anticancer naphthoquinone plumbagin with enhanced efficacy against resistant cancer cells and a genuine mode of action.
    Journal of inorganic biochemistry, 2014, Volume: 138

    Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Coordination Complexes; Cymenes; DNA; Female; Ferrous Compounds; Humans; Metallocenes; Monoterpenes; Naphthoquinones; Ruthenium; Uterine Cervical Neoplasms

2014
The study of naphthoquinones and their complexes with DNA by using Raman spectroscopy and surface enhanced Raman spectroscopy: new insight into interactions of DNA with plant secondary metabolites.
    BioMed research international, 2014, Volume: 2014

    Topics: DNA; DNA, B-Form; Naphthoquinones; Plants; Reactive Oxygen Species; Secondary Metabolism; Spectrum Analysis, Raman

2014
Juglone up-regulates sirt1 in skin cells under normal and UVB irradiated conditions.
    Journal of dermatological science, 2016, Volume: 81, Issue:3

    Topics: Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Fibroblasts; Humans; Keratinocytes; Naphthoquinones; NIMA-Interacting Peptidylprolyl Isomerase; Resveratrol; Signal Transduction; Sirtuin 1; Skin; Stilbenes; Ultraviolet Rays; Up-Regulation

2016
Discovery of natural naphthoquinones as sortase A inhibitors and potential anti-infective solutions against Staphylococcus aureus.
    Drug development research, 2019, Volume: 80, Issue:8

    Topics: Aminoacyltransferases; Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Catalytic Domain; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enterococcus faecalis; Inhibitory Concentration 50; Models, Molecular; Molecular Docking Simulation; Naphthoquinones; Protein Binding; Staphylococcus aureus; Staphylococcus epidermidis

2019
Impact of cytotoxic plant naphthoquinones, juglone, plumbagin, lawsone and 2-methoxy-1,4-naphthoquinone, on Chlamydomonas reinhardtii reveals the biochemical mechanism of juglone toxicity by rapid depletion of plastoquinol.
    Plant physiology and biochemistry : PPB, 2023, Volume: 197

    Topics: Antioxidants; Chlamydomonas reinhardtii; Naphthoquinones; Plants; Reactive Oxygen Species

2023
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