pleconaril has been researched along with oxazoles in 92 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 12 (13.04) | 18.2507 |
2000's | 44 (47.83) | 29.6817 |
2010's | 30 (32.61) | 24.3611 |
2020's | 6 (6.52) | 2.80 |
Authors | Studies |
---|---|
Abdel-Rahman, SM; Kearns, GL | 2 |
Abdel-Rahman, SM; Blowey, DL; Jacobs, RF; James, LP; Kearns, GL; Marshall, JD; Wells, TG | 1 |
Groarke, JM; Pevear, DC | 1 |
Rotbart, HA | 1 |
Groarke, JM; Pevear, DC; Seipel, ME; Tull, TM | 1 |
Hayden, FG | 1 |
Diana, GD; McKinlay, MA; Rogers, JM | 1 |
Bossart, W; Güngör, T; Lauener, R; Schmugge, M; Seger, RA | 1 |
Le Moing, V | 1 |
Sawyer, MH | 3 |
Schiff, GM; Sherwood, JR | 1 |
Flückiger, U | 1 |
Steele, RW; Yarush, LI | 1 |
Crump, CE; Hayden, FG; Kaiser, L | 1 |
Abdel-Rahman, SM; Bradley, JS; Capparelli, EV; Jacobs, RF; James, LP; Johnson, KM; Kearns, GL | 1 |
Ballesteros, F; Reina, J | 1 |
Forman, MS; Lederman, HM; Nowak-Wegrzyn, A; Phipatanakul, W; Winkelstein, JA | 1 |
Turner, RB | 1 |
Rotbart, HA; Webster, AD | 1 |
Romero, JR | 1 |
Nigrovic, LE | 1 |
Ansevin, CF | 1 |
Billich, A | 1 |
Alonso, EM; Aradottir, E; Shulman, ST | 1 |
Black, J; Leeman, B; Mundy, LM; Reed, N; Starlin, R; Trulock, E | 1 |
Chang, CM; Chang, YL; Chen, SJ; Chern, JH; Hsu, MC; Lee, CC; Lee, YC; Leong, MK; Li, WT; Peng, KC; Shia, KS; Shih, SR; Tai, CL; Tseng, HY; Tseng, SN | 1 |
Blatter, MM; Coats, T; Hassman, HA; Hayden, FG; Kim, K; Liu, S; Zhang, B | 1 |
Senior, K | 1 |
Ashkenazi, S; Bauer, S; Gottesman, G; Levi, I; Litmanovitz, I; Sirota, L | 1 |
Florea, NR; Maglio, D; Nicolau, DP | 1 |
Buscombe, JR; Johnson, MA; Thomson, AP; Tormey, VJ; Webster, AD | 1 |
Abzug, MJ; Blount, S; Bradley, J; Capparelli, EV; Cloud, G; Kimberlin, DW; Lakeman, F; Lepow, M; Mani, C; Powell, D; Romero, J; Sánchez, PJ; Whitley, RJ | 1 |
Andrews, PI; Bye, AM; Craig, ME; Lahra, MM; Nolan, MA; Prager, PC; Rawlinson, WD; Williams, GD | 1 |
Coats, TL; Collett, M; Cooper, EC; Hayden, FG; Herrington, DT; Hudson, S; Kim, K; Liu, S; McKinlay, M; Pevear, DC; Villano, SA | 1 |
Andrews, IP; Nolan, M; Prager, P; Williams, GD | 1 |
Chase, E; Harris, K; Katpally, U; Reisdorph, N; Siuzdak, G; Smith, TJ; Thomas, JJ | 1 |
Fleischer, R; Laessig, K | 1 |
Abzug, MJ | 2 |
Bryant, PA; Curtis, N; Dargaville, PA; Starr, M; Tingay, D | 1 |
Collett, MS; Demenczuk, TM; Herbertz, T; Ledford, RM; Patel, NR; Pevear, DC; Watanyar, A | 1 |
Bator, CM; Chakravarty, S; Demenczuk, TM; Ledford, RM; Pevear, DC; Rossmann, MG; Simpson, AA; Skochko, GA; Watanyar, A; Zhang, Y | 1 |
Webster, AD | 1 |
Birch-Hirschfeld, E; Hammerschmidt, E; Makarov, VA; Riabova, OB; Schmidtke, M; Schüler, S; Wutzler, P; Zell, R | 1 |
Collett, MS; Ledford, RM; Pevear, DC | 1 |
Barone, LR; Collett, MS; Demenczuk, TM; Hayden, FG; McKinlay, MA; Pevear, DC | 1 |
Bertino, JS; Gartung, AM; Liu, S; Ma, JD; Nafziger, AN; Rhodes, G | 1 |
Bertino, JS; Liu, S; Ma, JD; Nafziger, AN; Rhodes, G | 1 |
Byington, CL; Fujinami, RS; Libbey, JE; Rentz, AC; Whitby, FG | 1 |
Accortt, NA; Desmond, RA; Soong, SJ; Talley, L; Villano, SA; Whitley, RJ | 1 |
Berg, AK; Frisk, G; Korsgren, O; Olsson, A | 1 |
Makarov, VA; Riabova, OB; Schmidtke, M; Wutzler, P; Zieger, R | 1 |
Berggren, PO; Blixt, M; Holmberg, R; Juntti-Berggren, L; Klitz, W; Niklasson, B | 1 |
Baek, SH; Choi, HJ; Kwon, DH; Lim, CH; Song, JH | 1 |
Cardosa, MJ; Lewthwaite, P; Ooi, MH; Solomon, T; Wong, SC | 1 |
Harvala, H; Pajkrt, D; Wildenbeest, JG; Wolthers, KC | 1 |
Greenwood, V | 1 |
Boelens, JJ; Douma, JW; Rademaker, C; Sanders, EA; van de Ven, AA; van Loon, AM; van Montfrans, JM; Wensing, AM | 1 |
Cao, Q; Deng, Y; Ding, C; Feng, D; Gu, B; Hu, W; Wang, J; Xie, F; Yao, K; Zhang, C; Zhang, G; Zhou, F | 1 |
Benschop, KS; Koen, G; Kuijpers, TW; van den Broek, PJ; Vossen, AC; Wierenga, PC; Wildenbeest, JG; Wolthers, KC | 1 |
Hussain Basha, S; Prasad, RN | 1 |
Aguayo, E; Birkus, G; Cihlar, T; Jordan, R; Lee, G; Mello, C; Rodriguez, M | 1 |
Benschop, KSM; Koen, G; Minnaar, RP; Pajkrt, D; van den Broek, PJ; van Hemert, FJ; Vossen, ACTM; Westerhuis, BM; Wildenbeest, JG; Wolthers, KC | 1 |
Fokine, A; Kihara, D; Kuhn, RJ; Liu, Y; Long, F; Meng, G; Rossmann, MG; Sheng, J; Shin, WH | 1 |
Bernard, A; Cabiddu, MG; Lacroix, C; Leyssen, P; Neyts, J; Pompei, R | 1 |
Angius, F; Coluccia, A; Laconi, S; Lacroix, C; Leyssen, P; Neyts, J; Pompei, R; Silvestri, R | 1 |
Galabov, AS; Nikolova, I; Stoyanova, A | 1 |
Baggen, J; Delang, L; Froeyen, M; George, S; Hilgenfeld, R; Leyssen, P; Meijer, A; Neyts, J; Sun, L; Thibaut, HJ; van Kuppeveld, FJ; Vernachio, J; Zhang, L | 1 |
Braun, H; Glen, RC; Kirchmair, J; Makarov, VA; Riabova, OB; Sauerbrei, A; Schmidtke, M; Williamson, MJ | 1 |
Abzug, MJ; Acosta, EP; Cloud, G; Dennehy, P; Jacobs, RF; Jester, P; Kimberlin, D; Krogstad, P; Lawrence, R; Michaels, MG; Palmer, A; Robinson, J; Romero, JR; Sánchez, PJ; Shelton, M; Sood, SK; Storch, GA; Wald, E; Whitley, R; Wilson, G | 1 |
Häkkinen, H; Lahtinen, T; Malola, S; Marjomäki, V; Martikainen, M; Permi, P; Salorinne, K | 1 |
Cheng, XY; Jiang, JD; Kong, LY; Li, YH; Song, DQ; Tang, S; Wang, HQ; Zhang, X | 1 |
Day, CW; Evans, WJ; Nicolaou, KC; Smee, DF; Tarbet, EB | 1 |
Hernández, M | 1 |
Muller, WJ | 1 |
Dimitrov, V; Dobrikov, G; Galabov, AS; Nikolova, I; Philipov, S; Pürstinger, G; Stoyanova, A | 1 |
Groenhof, G; Häkkinen, H; Malola, S; Pohjolainen, E | 1 |
Abdelnabi, R; Delang, L; Froeyen, M; Luyten, W; Ma, Y; Mirabelli, C; Neyts, J | 1 |
Baršić, B; Kutleša, M; Radanović, I; Rkman, D; Zekan, P | 1 |
DeBiasi, RL; Harik, N | 1 |
Lv, W; Wang, Y; Zhang, M; Zhang, Y | 1 |
Blaas, D; Goessweiner-Mohr, N; Kirchmair, J; Makarov, VA; Marlovits, TC; Mathai, N; Pasin, M; Real-Hohn, A; Richter, M; Schmidtke, M; Verdaguer, N; Wald, J; Walther, C; Zanella, I | 1 |
Honkimaa, A; Hyöty, H; Sioofy-Khojine, AB | 1 |
Egorova, A; Ekins, S; Jahn, B; Kazakova, E; Makarov, V; Schmidtke, M | 1 |
Egorova, A; Ekins, S; Galochkina, A; Makarov, V; Volobueva, A; Zarubaev, V | 1 |
Berggren, PO; Juntti-Berggren, L; Klitz, W; Lindquist, L; Niklasson, B | 1 |
Galabov, AS; Stoyanova, A | 1 |
Füzik, T; Kalynych, S; Moravcová, J; Plevka, P | 1 |
19 review(s) available for pleconaril and oxazoles
Article | Year |
---|---|
Antiviral therapy for enteroviral infections.
Topics: Adult; Antiviral Agents; Enterovirus Infections; Humans; Immunization, Passive; Infant, Newborn; Oxadiazoles; Oxazoles; Randomized Controlled Trials as Topic | 1999 |
Update on influenza and rhinovirus infections.
Topics: Acetamides; Amines; Antiviral Agents; Common Cold; Guanidines; Humans; Influenza, Human; Intercellular Adhesion Molecule-1; Neuraminidase; Oseltamivir; Oxadiazoles; Oxazoles; Picornaviridae Infections; Pyrans; Recombinant Proteins; Rhinovirus; Sialic Acids; Zanamivir | 1999 |
Pleconaril. A broad spectrum antipicornaviral agent.
Topics: Antiviral Agents; Enterovirus; Humans; Meningitis, Viral; Oxadiazoles; Oxazoles; Picornaviridae Infections | 1999 |
Enterovirus infections: diagnosis and treatment.
Topics: Antiviral Agents; Child; Cost of Illness; Enterovirus; Enterovirus Infections; Humans; Meningitis, Viral; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; Serologic Tests | 1999 |
[On new antiviral drugs, new viruses and old known bacteria].
Topics: Anti-Bacterial Agents; Antiviral Agents; Bacteria; Bacterial Infections; Enterovirus; Enterovirus Infections; Humans; Oxadiazoles; Oxazoles; Virus Diseases; Viruses | 1999 |
[Pleconaril, a new aniviral drug with activity against picornavirus].
Topics: Animals; Antiviral Agents; Drug Resistance; Humans; Oxadiazoles; Oxazoles; Picornaviridae; Picornaviridae Infections | 2000 |
The treatment of rhinovirus infections: progress and potential.
Topics: 3C Viral Proteases; Antiviral Agents; Clinical Trials as Topic; Combined Modality Therapy; Common Cold; Cysteine Endopeptidases; Dietary Supplements; Drug Therapy, Combination; Echinacea; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Intercellular Adhesion Molecule-1; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Phytotherapy; Picornaviridae Infections; Plant Extracts; Plants, Medicinal; Pyrrolidinones; Receptors, Virus; Rhinovirus; Valine; Viral Proteins; Zinc | 2001 |
Enterovirus infections: diagnosis and treatment.
Topics: Adolescent; Adult; Antiviral Agents; Child; Child, Preschool; Enterovirus Infections; Female; Humans; Infant; Infant, Newborn; Meningitis, Viral; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Infectious; Sepsis | 2001 |
What's new with enteroviral infections?
Topics: Antiviral Agents; Cost-Benefit Analysis; Disease Outbreaks; Enterovirus Infections; Humans; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; Romania; Scotland | 2001 |
Pleconaril Sanofi Synthélabo/ViroPharma.
Topics: Antiviral Agents; Clinical Trials as Topic; Contraindications; Drugs, Investigational; Humans; Oxadiazoles; Oxazoles; Picornaviridae; Picornaviridae Infections; Structure-Activity Relationship | 2000 |
Enterovirus infections: diagnosis and treatment.
Topics: Adult; Antiviral Agents; Child; Clinical Trials as Topic; Enterovirus Infections; Humans; Meningitis, Viral; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; Virus Replication | 2002 |
Pleconaril, a novel antipicornaviral agent.
Topics: Adolescent; Adult; Aged; Antiviral Agents; Area Under Curve; Biological Availability; Half-Life; Humans; Middle Aged; Oxadiazoles; Oxazoles; Picornaviridae Infections; Randomized Controlled Trials as Topic | 2003 |
Presentation, diagnosis, and management of enterovirus infections in neonates.
Topics: Adult; Antiviral Agents; Child; Enterovirus Infections; Humans; Infant, Newborn; Oxadiazoles; Oxazoles; Randomized Controlled Trials as Topic; Viral Vaccines | 2004 |
Pleconaril--an advance in the treatment of enteroviral infection in immuno-compromised patients.
Topics: Antiviral Agents; Enterovirus Infections; Humans; Immunocompromised Host; Oxadiazoles; Oxazoles; Poliovirus | 2005 |
Clinical features, diagnosis, and management of enterovirus 71.
Topics: Disease Management; Enterovirus A, Human; Enterovirus Infections; Humans; Oxadiazoles; Oxazoles | 2010 |
The need for treatment against human parechoviruses: how, why and when?
Topics: Animals; Antiviral Agents; Central Nervous System Infections; Disease Models, Animal; Humans; Infant, Newborn; Oxadiazoles; Oxazoles; Parechovirus; Picornaviridae Infections; Sepsis | 2010 |
The enteroviruses: problems in need of treatments.
Topics: Antiviral Agents; Drug Discovery; Enterovirus Infections; Global Health; Humans; Oxadiazoles; Oxazoles | 2014 |
Treatment of perinatal viral infections to improve neurologic outcomes.
Topics: Acyclovir; Antiviral Agents; Brain; Cognition; Cognition Disorders; Encephalitis, Herpes Simplex; Enterovirus Infections; Female; Ganciclovir; HIV Infections; Humans; Infant, Newborn; Nervous System Diseases; Oxadiazoles; Oxazoles; Pregnancy; Valganciclovir; Virus Diseases | 2017 |
Neonatal nonpolio enterovirus and parechovirus infections.
Topics: Antiviral Agents; Cross Infection; Enterovirus; Enterovirus Infections; Female; Fomites; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Oxadiazoles; Oxazoles; Parechovirus; Phenyl Ethers; Picornaviridae Infections; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Infectious | 2018 |
15 trial(s) available for pleconaril and oxazoles
Article | Year |
---|---|
Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution and effect of food.
Topics: Administration, Oral; Adolescent; Adult; Antiviral Agents; Cross-Over Studies; Food; Humans; Oxadiazoles; Oxazoles; Picornaviridae; Solutions | 1998 |
Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution in children and adolescents. Pediatric Pharmacology Research Unit Network.
Topics: Administration, Oral; Aging; Antiviral Agents; Area Under Curve; Child; Child, Preschool; Female; Humans; Male; Oxadiazoles; Oxazoles; Pharmaceutical Solutions | 1999 |
Single oral dose escalation pharmacokinetics of pleconaril (VP 63843) capsules in adults.
Topics: Administration, Oral; Adult; Antiviral Agents; Area Under Curve; Capsules; Dose-Response Relationship, Drug; Double-Blind Method; Dyspepsia; Humans; Male; Middle Aged; Oxadiazoles; Oxazoles; Single-Blind Method | 1999 |
Clinical activity of pleconaril in an experimentally induced coxsackievirus A21 respiratory infection.
Topics: Adolescent; Adult; Antibodies, Viral; Antiviral Agents; Coxsackievirus Infections; Enterovirus; Female; Humans; Male; Middle Aged; Mucus; Nose; Oxadiazoles; Oxazoles; Respiratory Tract Infections; Virus Shedding | 2000 |
Single dose pharmacokinetics of pleconaril in neonates. Pediatric Pharmacology Research Unit Network.
Topics: Administration, Oral; Age Factors; Antiviral Agents; Area Under Curve; Biological Availability; Enterovirus Infections; Female; Humans; Infant, Newborn; Male; Oxadiazoles; Oxazoles | 2000 |
Treatment of potentially life-threatening enterovirus infections with pleconaril.
Topics: Adolescent; Adult; Aged; Antiviral Agents; Child; Child, Preschool; Chronic Disease; Enterovirus; Enterovirus Infections; Follow-Up Studies; Humans; Infant, Newborn; Meningoencephalitis; Middle Aged; Oxadiazoles; Oxazoles; Treatment Outcome | 2001 |
Oral pleconaril treatment of picornavirus-associated viral respiratory illness in adults: efficacy and tolerability in phase II clinical trials.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Double-Blind Method; Female; Humans; Male; Middle Aged; Oxadiazoles; Oxazoles; Picornaviridae Infections; Respiratory Tract Infections; Virus Shedding | 2002 |
Severe Coxsackie virus B infection in preterm newborns treated with pleconaril.
Topics: Antiviral Agents; Coxsackievirus Infections; Diseases in Twins; Enterovirus B, Human; Female; Humans; Infant, Newborn; Infant, Premature; Oxadiazoles; Oxazoles | 2002 |
Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis.
Topics: Administration, Oral; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Enterovirus Infections; Female; Follow-Up Studies; Humans; Infant; Male; Meningitis, Viral; Oxadiazoles; Oxazoles; Probability; Reference Values; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2003 |
Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trials.
Topics: Administration, Oral; Adult; Antiviral Agents; Common Cold; Diarrhea; Double-Blind Method; Female; Humans; Male; Nausea; Oxadiazoles; Oxazoles; Picornaviridae; Picornaviridae Infections; Prospective Studies; Treatment Outcome | 2003 |
Relationship of pleconaril susceptibility and clinical outcomes in treatment of common colds caused by rhinoviruses.
Topics: Antiviral Agents; Common Cold; Double-Blind Method; Drug Resistance, Bacterial; Humans; Oxadiazoles; Oxazoles; Rhinovirus | 2005 |
The effect of oral pleconaril on hepatic cytochrome P450 3A activity in healthy adults using intravenous midazolam as a probe.
Topics: Administration, Oral; Adult; Antiviral Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Injections, Intravenous; Liver; Male; Midazolam; Oxadiazoles; Oxazoles | 2006 |
Enteroviral meningitis: natural history and outcome of pleconaril therapy.
Topics: Adult; Antiviral Agents; Double-Blind Method; Enterovirus Infections; Female; Headache; Humans; Male; Meningitis, Viral; Multivariate Analysis; Oxadiazoles; Oxazoles; Treatment Outcome | 2006 |
A Randomized, Double-Blind, Placebo-Controlled Trial of Pleconaril for the Treatment of Neonates With Enterovirus Sepsis.
Topics: Antiviral Agents; Double-Blind Method; Enterovirus; Enterovirus Infections; Female; Humans; Infant; Infant, Newborn; Male; Neonatal Sepsis; Oropharynx; Oxadiazoles; Oxazoles; Rectum | 2016 |
[A randomized, double-blind, placebo-controlled trial of pleconaril for the treatment of neonates with enterovirus sepsis].
Topics: Antiviral Agents; Double-Blind Method; Enterovirus Infections; Female; Humans; Infant, Newborn; Male; Neonatal Sepsis; Oxadiazoles; Oxazoles; Placebo Effect; Reproducibility of Results; Time Factors; Treatment Outcome | 2016 |
58 other study(ies) available for pleconaril and oxazoles
Article | Year |
---|---|
Attenuated virulence of pleconaril-resistant coxsackievirus B3 variants.
Topics: Animals; Antiviral Agents; Binding Sites; Capsid; Capsid Proteins; Drug Resistance, Microbial; Enterovirus B, Human; Genetic Variation; Male; Mice; Mice, Inbred BALB C; Oxadiazoles; Oxazoles; RNA, Viral; Sequence Analysis, RNA | 1999 |
Activity of pleconaril against enteroviruses.
Topics: Animals; Animals, Newborn; Animals, Suckling; Antiviral Agents; Cells, Cultured; Coxsackievirus Infections; Enterovirus; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Oxadiazoles; Oxazoles; Serotyping; Virus Replication | 1999 |
Chronic enteroviral meningo-encephalitis in X-linked agammaglobulinaemia: favourable response to anti-enteroviral treatment.
Topics: Adult; Agammaglobulinemia; Antiviral Agents; Enterovirus; Genetic Linkage; Humans; Male; Meningoencephalitis; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; X Chromosome | 1999 |
[New antivirals for respiratory tract viruses].
Topics: Antiviral Agents; Drug Approval; France; Guanidines; Humans; Influenza, Human; Neuraminidase; Oxadiazoles; Oxazoles; Picornaviridae Infections; Pyrans; Respiratory Tract Infections; Sialic Acids; Zanamivir | 1999 |
Diagnosis and prospective treatment of enteroviral infections in children.
Topics: Antiviral Agents; Child; Diagnosis, Differential; Enterovirus Infections; Humans; Oxadiazoles; Oxazoles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral | 2000 |
In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses.
Topics: Antiviral Agents; Cell Survival; Cells, Cultured; Common Cold; Humans; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Pyrrolidinones; Reverse Transcriptase Polymerase Chain Reaction; Rhinovirus; Spectrophotometry; Valine | 2000 |
Successful treatment of enterovirus infection with the use of pleconaril in 2 infants with severe combined immunodeficiency.
Topics: Antiviral Agents; Enterovirus Infections; Feces; Female; Humans; Infant; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; RNA, Viral; Severe Combined Immunodeficiency | 2001 |
Pleconaril: a novel antipicornaviral drug.
Topics: Antiviral Agents; Clinical Trials as Topic; Enterovirus Infections; Humans; Oxadiazoles; Oxazoles | 2001 |
Treatment of ALS with pleconaril.
Topics: Aged; Amyotrophic Lateral Sclerosis; Humans; Male; Oxadiazoles; Oxazoles | 2001 |
Severe neonatal enteroviral hepatitis treated with pleconaril.
Topics: Antiviral Agents; Echovirus Infections; Enterovirus B, Human; Hepatitis, Viral, Human; Humans; Infant, Newborn; Liver Failure; Oxadiazoles; Oxazoles | 2001 |
Acute flaccid paralysis syndrome associated with echovirus 19, managed with pleconaril and intravenous immunoglobulin.
Topics: Adult; Antiviral Agents; Echovirus Infections; Female; Humans; Immunocompromised Host; Immunoglobulins, Intravenous; Kidney Transplantation; Lung Transplantation; Oxadiazoles; Oxazoles; Paraplegia | 2001 |
Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: a novel class of potent and selective human enterovirus 71 inhibitors.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Enterovirus; Humans; Imidazoles; Neutralization Tests; Oxadiazoles; Oxazoles; Pyridines; Structure-Activity Relationship; Viral Plaque Assay | 2002 |
FDA panel rejects common cold treatment.
Topics: Antiviral Agents; Common Cold; Drug Approval; Female; Humans; Oxadiazoles; Oxazoles; United States; United States Food and Drug Administration | 2002 |
Cold comfort.
Topics: Antiviral Agents; Common Cold; Drug Approval; Humans; Oxadiazoles; Oxazoles; United States; United States Food and Drug Administration | 2002 |
SPECT scans for monitoring response to pleconaril therapy in chronic enteroviral meningoencephalitis.
Topics: Adolescent; Adult; Antiviral Agents; Common Variable Immunodeficiency; Enterovirus; Enterovirus Infections; Female; HIV Infections; Humans; Immunocompromised Host; Male; Meningoencephalitis; Oxadiazoles; Oxazoles; Tomography, Emission-Computed, Single-Photon | 2003 |
Survival after pulmonary edema due to enterovirus 71 encephalitis.
Topics: Acute Disease; Antiviral Agents; Child, Preschool; Combined Modality Therapy; Disease Outbreaks; Encephalitis, Viral; Enterovirus; Enterovirus Infections; Female; Follow-Up Studies; Humans; Immunoglobulins, Intravenous; Infant; Magnetic Resonance Imaging; Male; New South Wales; Oxadiazoles; Oxazoles; Pulmonary Edema; Survival Analysis; Survivors | 2003 |
Neurogenic pulmonary edema in enterovirus 71 encephalitis is not uniformly fatal but causes severe morbidity in survivors.
Topics: Antiviral Agents; Child, Preschool; Echocardiography; Encephalitis, Viral; Enterovirus; Enterovirus Infections; Female; Follow-Up Studies; Humans; Infant; Intensive Care Units, Pediatric; Magnetic Resonance Imaging; Male; Oxadiazoles; Oxazoles; Pulmonary Edema; Respiration, Artificial; Time Factors | 2003 |
Human rhinovirus capsid dynamics is controlled by canyon flexibility.
Topics: Antibodies, Viral; Antigen-Antibody Reactions; Binding Sites; Capsid; HeLa Cells; Humans; Immunoglobulin Fab Fragments; Isoxazoles; Microscopy, Electron; Models, Molecular; Mutation; Oxadiazoles; Oxazoles; Rhinovirus; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Virus Assembly | 2003 |
Safety and efficacy evaluation of pleconaril for treatment of the common cold.
Topics: Adult; Antiviral Agents; Common Cold; Controlled Clinical Trials as Topic; Drug Resistance, Viral; Evaluation Studies as Topic; Humans; Oxadiazoles; Oxazoles; Picornaviridae Infections | 2003 |
Neonatal coxsackie B virus infection-a treatable disease?
Topics: Antiviral Agents; Cardiomyopathies; Coxsackievirus Infections; Disseminated Intravascular Coagulation; Enterovirus B, Human; Hepatitis; Humans; Infant; Infant, Newborn; Infant, Premature; Infectious Disease Transmission, Vertical; Meningoencephalitis; Oxadiazoles; Oxazoles; Perinatal Care; Polymerase Chain Reaction; Thrombocytopenia | 2004 |
VP1 sequencing of all human rhinovirus serotypes: insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds.
Topics: Amino Acid Sequence; Antiviral Agents; Binding Sites; Capsid; Drug Resistance, Viral; HeLa Cells; Humans; Models, Molecular; Molecular Sequence Data; Neutralization Tests; Oxadiazoles; Oxazoles; Phylogeny; Rhinovirus; Viral Proteins | 2004 |
Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds.
Topics: Antiviral Agents; Binding Sites; Crystallization; HeLa Cells; Humans; Models, Molecular; Oxadiazoles; Oxazoles; Rhinovirus; Virus Assembly; Virus Replication; X-Ray Diffraction | 2004 |
Susceptibility of coxsackievirus B3 laboratory strains and clinical isolates to the capsid function inhibitor pleconaril: antiviral studies with virus chimeras demonstrate the crucial role of amino acid 1092 in treatment.
Topics: Amino Acid Substitution; Animals; Antiviral Agents; Capsid; Capsid Proteins; Cell Line; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Resistance, Viral; Enterovirus B, Human; Enterovirus Infections; Humans; Hydrophobic and Hydrophilic Interactions; Oxadiazoles; Oxazoles; Polymorphism, Genetic | 2005 |
Insights into the genetic basis for natural phenotypic resistance of human rhinoviruses to pleconaril.
Topics: Antiviral Agents; Capsid Proteins; Drug Resistance, Viral; Humans; Oxadiazoles; Oxazoles; Rhinovirus | 2005 |
Duration of pleconaril effect on cytochrome P450 3A activity in healthy adults using the oral biomarker midazolam.
Topics: Adult; Antiviral Agents; Area Under Curve; Cytochrome P-450 CYP3A; Enzyme Induction; Female; Half-Life; Humans; Hypnotics and Sedatives; Intestines; Liver; Male; Midazolam; Middle Aged; Oxadiazoles; Oxazoles | 2006 |
Investigation of treatment failure in neonatal echovirus 7 infection.
Topics: Antiviral Agents; Enterovirus B, Human; Enterovirus Infections; Fatal Outcome; Female; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Molecular Sequence Data; Oxadiazoles; Oxazoles; Sequence Analysis, DNA; Treatment Failure | 2006 |
Antiviral treatment of Coxsackie B virus infection in human pancreatic islets.
Topics: Antiviral Agents; Cells, Cultured; Coxsackievirus Infections; Cytopathogenic Effect, Viral; Diabetes Mellitus, Type 1; Enterovirus B, Human; Humans; Insulin; Islets of Langerhans; Oxadiazoles; Oxazoles | 2007 |
New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3.
Topics: Antiviral Agents; Drug Design; Drug Resistance, Viral; Enterovirus B, Human; Enterovirus Infections; HeLa Cells; Humans; Isoxazoles; Mutation; Oxadiazoles; Oxazoles | 2009 |
Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats.
Topics: Animals; Antibodies, Viral; Antiviral Agents; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Humans; Immunologic Factors; Mice; Oxadiazoles; Oxazoles; Parechovirus; Picornaviridae Infections; Rats; Rats, Inbred BB; Ribavirin | 2009 |
Anti-human rhinovirus activity of raoulic acid from Raoulia australis.
Topics: Antiviral Agents; Asteraceae; Common Cold; Humans; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Phytotherapy; Picornaviridae Infections; Plant Extracts; Rhinovirus; Ribavirin; Terpenes; Virus Internalization | 2010 |
Curing the common cold.
Topics: Antiviral Agents; Common Cold; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Oxadiazoles; Oxazoles; Rhinovirus; Viral Structural Proteins; Viral Vaccines | 2011 |
Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia.
Topics: Adolescent; Agammaglobulinemia; Antiviral Agents; Caliciviridae Infections; Chronic Disease; Drug Resistance, Viral; Feces; Humans; Immunocompromised Host; Male; Norovirus; Oxadiazoles; Oxazoles; Parechovirus; Picornaviridae Infections; Protein-Losing Enteropathies | 2011 |
In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infection.
Topics: Animals; Animals, Newborn; Antiviral Agents; Cell Line, Tumor; Cell Survival; Child, Preschool; Disease Models, Animal; Enterovirus A, Human; Enterovirus Infections; Humans; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Ribavirin; Survival Analysis | 2012 |
Pleconaril revisited: clinical course of chronic enteroviral meningoencephalitis after treatment correlates with in vitro susceptibility.
Topics: Antiviral Agents; Cerebrospinal Fluid; Child; Chronic Disease; Drug Resistance, Viral; Enterovirus; Enterovirus Infections; Female; Humans; Immunoglobulins, Intravenous; Male; Meningoencephalitis; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; Treatment Outcome | 2012 |
In-Silico screening of Pleconaril and its novel substituted derivatives with Neuraminidase of H1N1 Influenza strain.
Topics: Amino Acids; Antiviral Agents; Binding Sites; Biocatalysis; Catalytic Domain; Drug Evaluation, Preclinical; Drug Resistance, Viral; Enzyme Inhibitors; Humans; Hydrogen Bonding; Influenza A Virus, H1N1 Subtype; Influenza, Human; Models, Molecular; Molecular Structure; Neuraminidase; Oseltamivir; Oxadiazoles; Oxazoles; Protein Binding; Protein Structure, Tertiary | 2012 |
Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C.
Topics: Antiviral Agents; Common Cold; Dose-Response Relationship, Drug; HeLa Cells; Humans; In Vitro Techniques; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Piperidines; Pyridazines; Pyrrolidinones; Replicon; Rhinovirus; RNA, Viral; Tubercidin; Valine; Virus Replication | 2014 |
Genetic and antigenic structural characterization for resistance of echovirus 11 to pleconaril in an immunocompromised patient.
Topics: Antigens, Viral; Antiviral Agents; Drug Resistance, Viral; Echovirus Infections; Enterovirus B, Human; Gene Expression Regulation, Viral; Humans; Immunoglobulins, Intravenous; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxadiazoles; Oxazoles | 2015 |
Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.
Topics: Antiviral Agents; Capsid; Child; Crystallography, X-Ray; Enterovirus D, Human; Enterovirus Infections; Humans; Hydrophobic and Hydrophilic Interactions; Oxadiazoles; Oxazoles; Respiratory Tract Diseases; United States; Viral Proteins | 2015 |
Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Enterovirus; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Piperidines; Pyridazines; Structure-Activity Relationship | 2015 |
In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses.
Topics: Antiviral Agents; Capsid Proteins; Humans; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Piperidines; Protein Binding; Pyridazines; Rhinovirus | 2015 |
Effect of consecutive alternating administration (CAA) of a triple anti-enteroviral combination on Coxsackievirus B1 neuroinfection in mice.
Topics: Animals; Antiviral Agents; Apomorphine; Brain; Central Nervous System Infections; Coxsackievirus Infections; Disease Models, Animal; Drug Resistance, Viral; Drug Therapy, Combination; Enterovirus B, Human; Guanidine; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Survival Analysis; Treatment Outcome | 2015 |
Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.
Topics: Antiviral Agents; Drug Resistance, Viral; Enterovirus D, Human; Enterovirus Infections; Humans; Microbial Sensitivity Tests; Models, Molecular; Oxadiazoles; Oxazoles; Receptors, Drug; Respiratory Tract Infections; Viral Proteins; Virus Replication | 2015 |
Molecular mechanism of a specific capsid binder resistance caused by mutations outside the binding pocket.
Topics: Amino Acid Substitution; Antiviral Agents; Binding Sites; Capsid Proteins; DNA Mutational Analysis; Drug Resistance, Viral; Enterovirus B, Human; HeLa Cells; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Dynamics Simulation; Mutation, Missense; Oxadiazoles; Oxazoles; Protein Binding; Protein Conformation; Virus Replication | 2015 |
Hydrophobic pocket targeting probes for enteroviruses.
Topics: Cell Line, Tumor; Coxsackievirus Infections; Enterovirus B, Human; Fluorescent Dyes; Gold; Humans; Hydrophobic and Hydrophilic Interactions; Oxadiazoles; Oxazoles | 2015 |
SAR evolution and discovery of benzenesulfonyl matrinanes as a novel class of potential coxsakievirus inhibitors.
Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Chlorocebus aethiops; Coxsackievirus Infections; Drug Discovery; Drug Resistance, Viral; Enterovirus; Humans; Isoquinolines; Male; Mice; Oxadiazoles; Oxazoles; RNA, Viral; Serine Endopeptidases; Structure-Activity Relationship; Sulfonamides; Vero Cells; Viral Proteins | 2016 |
Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds.
Topics: A549 Cells; Antimetabolites; Antiviral Agents; Benzimidazoles; Enterovirus A, Human; Enterovirus D, Human; Guanine; HeLa Cells; Humans; Oxadiazoles; Oxazoles; Oximes; Picornaviridae; Piperazines; Piperidines; Pyridazines; Rhabdomyosarcoma; Rhinovirus; Ribavirin; Sulfonamides | 2016 |
Anti-enteroviral triple combination of viral replication inhibitors: activity against coxsackievirus B1 neuroinfection in mice.
Topics: Animals; Antiviral Agents; Apomorphine; Cells, Cultured; Coxsackievirus Infections; Drug Resistance, Viral; Drug Therapy, Combination; Enterovirus B, Human; Humans; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Nitriles; Oxadiazoles; Oxazoles; Virus Replication | 2015 |
Exploring Strategies for Labeling Viruses with Gold Nanoclusters through Non-equilibrium Molecular Dynamics Simulations.
Topics: Antiviral Agents; Binding Sites; Capsid; Enterovirus; Gold; Hydrophobic and Hydrophilic Interactions; Ligands; Metal Nanoparticles; Molecular Dynamics Simulation; Oxadiazoles; Oxazoles; Palmitic Acid; Thermodynamics | 2017 |
New class of early-stage enterovirus inhibitors with a novel mechanism of action.
Topics: Antiviral Agents; Capsid; Capsid Proteins; Cell Line; Cytopathogenic Effect, Viral; Drug Resistance, Viral; Drug Synergism; Enterovirus B, Human; Enterovirus Infections; Genotype; Humans; Molecular Conformation; Molecular Docking Simulation; Oxadiazoles; Oxazoles; para-Aminobenzoates; Protein Binding; RNA, Viral; Structure-Activity Relationship; Virus Replication | 2017 |
Chronic meningoencephalitis caused by Echo virus 6 in a patient with common variable immunodeficiency : Successful treatment with pleconaril.
Topics: Adult; Common Variable Immunodeficiency; Echovirus 6, Human; Echovirus Infections; Humans; Male; Meningoencephalitis; Oxadiazoles; Oxazoles; Treatment Outcome | 2018 |
Automated cell-based luminescence assay for profiling antiviral compound activity against enteroviruses.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Enterovirus; Enterovirus Infections; HeLa Cells; Humans; Isoxazoles; Luminescent Measurements; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Phenylalanine; Pyrrolidinones; Valine; Vero Cells | 2019 |
Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site.
Topics: Antiviral Agents; Binding Sites; Capsid; Cryoelectron Microscopy; Drug Resistance, Viral; HeLa Cells; Humans; Models, Molecular; Molecular Structure; Oxadiazoles; Oxazoles; Picornaviridae Infections; Protein Binding; Protein Conformation; Rhinovirus; Structure-Activity Relationship; Viral Proteins | 2019 |
A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses.
Topics: A549 Cells; Amides; Antiviral Agents; Azithromycin; Benzimidazoles; Coxsackievirus Infections; Diabetes Mellitus, Type 1; Drug Repositioning; Enterovirus B, Human; Fluoxetine; Guanidine; Humans; Immunoglobulin G; Lovastatin; Oxadiazoles; Oxazoles; Oximes; Pyrazines; Ribavirin; Sulfonamides | 2020 |
Novel pleconaril derivatives: Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses.
Topics: Animals; Antiviral Agents; Cell Survival; Dose-Response Relationship, Drug; Enterovirus; HeLa Cells; Humans; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Oxazoles; Structure-Activity Relationship | 2020 |
The Evolution of Pleconaril: Modified
Topics: Animals; Antiviral Agents; Cell Death; Chlorocebus aethiops; Dogs; Enterovirus B, Human; Madin Darby Canine Kidney Cells; Oxadiazoles; Oxazoles; Piperazines; Vero Cells | 2020 |
Effectiveness of Antivirals in a Type 1 Diabetes Model and the Move Toward Human Trials.
Topics: Adult; Alkynes; Animals; Antiviral Agents; Benzoxazines; Cyclopropanes; Diabetes Mellitus, Type 1; Humans; Male; Oxadiazoles; Oxazoles; Proof of Concept Study; Rats; Ribavirin | 2020 |
Effect of Consecutive Alternating Administration of a Triple Combination of Anti-Enteroviral Compounds in Mice Infected with Coxsackievirus B3.
Topics: Animals; Antiviral Agents; Apomorphine; Cell Line; Coxsackievirus Infections; Disease Models, Animal; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; Enterovirus B, Human; Humans; Mice; Nitriles; Oxadiazoles; Oxazoles; Virus Replication | 2020 |
Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds.
Topics: Antiviral Agents; Capsid; Capsid Proteins; Conjunctivitis, Acute Hemorrhagic; Cryoelectron Microscopy; Enterovirus D, Human; Humans; Oxadiazoles; Oxazoles; Virion | 2022 |