pld118 and cycloleucine
pld118 has been researched along with cycloleucine in 10 studies
Compound Research Comparison
| Studies (pld118) | Trials (pld118) | Recent Studies (post-2010) (pld118) | Studies (cycloleucine) | Trials (cycloleucine) | Recent Studies (post-2010) (cycloleucine) |
|---|---|---|---|---|---|
| 13 | 0 | 2 | 1,238 | 4 | 55 |
Research
Studies (10)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ziegelbauer, K | 1 |
| Babczinski, P; Schönfeld, W; Ziegelbauer, K | 1 |
| Dorrell, S | 1 |
| Bacher, J; Groll, AH; Kelaher, AM; Mickiene, D; Petraitiene, R; Petraitis, V; Sarafandi, AA; Sein, T; Walsh, TJ | 2 |
| Bogaards, JJ; Mildner, B; Oresković, K; Parnham, MJ; Schrander, F; Schut, MW | 1 |
| Yeates, C | 1 |
| Ergovic, G; Galic, T; Geschke, U; Hasenoehrl, A; Marsic, N; Mittendorf, J; Schmidt, A; Schoenfeld, W; Skerlev, M | 1 |
| Avdagić, A; Bratos, I; Dumić, M; Fistrić, I; Hamersak, Z; Ilijas, M; Marković, VG; Novak, P; Tepes, P | 1 |
| Ábrahámi, R; Forró, E; Fülöp, F; Kiss, L; Orsy, G | 1 |
Reviews
1 review(s) available for pld118 and cycloleucine
| Article | Year |
|---|---|
Icofungipen (PLIVA).
Topics: Animals; Antifungal Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Contraindications; Cycloleucine; Humans; Mycoses; Structure-Activity Relationship | 2005 |
Other Studies
9 other study(ies) available for pld118 and cycloleucine
| Article | Year |
|---|---|
Decreased accumulation or increased isoleucyl-tRNA synthetase activity confers resistance to the cyclic beta-amino acid BAY 10-8888 in Candida albicans and Candida tropicalis.
Topics: Candida; Candida albicans; Cell Division; Cycloleucine; Drug Resistance, Microbial; Isoleucine-tRNA Ligase; Microbial Sensitivity Tests; Mutation | 1998 |
Molecular mode of action of the antifungal beta-amino acid BAY 10-8888.
Topics: Amino Acids; Antifungal Agents; Biological Transport, Active; Candida albicans; Culture Media; Cycloleucine; Isoleucine; Isoleucine-tRNA Ligase; Protein Biosynthesis | 1998 |
Overcoming drug-resistant yeast infections.
Topics: Antifungal Agents; Cycloleucine; Drug Resistance, Fungal; Humans; Mycoses; Yeasts | 2002 |
Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans.
Topics: Animals; Antifungal Agents; Area Under Curve; Candida albicans; Candidiasis; Candidiasis, Oral; Cycloleucine; Drug Resistance, Fungal; Enzyme Inhibitors; Esophageal Diseases; Female; Fluconazole; Half-Life; Immunosuppression Therapy; Isoleucine-tRNA Ligase; Rabbits | 2004 |
The novel antifungal agent PLD-118 is neither metabolized by liver microsomes nor inhibits cytochrome P450 in vitro.
Topics: Administration, Oral; Animals; Antifungal Agents; Chemistry, Pharmaceutical; Cycloleucine; Cytochrome P-450 Enzyme System; Dogs; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Rats; Ribosomal Protein S9; Ribosomal Proteins | 2005 |
Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits.
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Culture Media; Cycloleucine; Female; Immunosuppression Therapy; Isoleucine-tRNA Ligase; Kidney; Liver; Neutropenia; Rabbits; Spleen | 2005 |
In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans.
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Cycloleucine; Drug Interactions; Hydrogen-Ion Concentration; Isoleucine; Male; Mice; Microbial Sensitivity Tests; Rats; Rats, Sprague-Dawley; Temperature | 2006 |
LC-NMR and LC-MS identification of an impurity in a novel antifungal drug icofungipen.
Topics: Antifungal Agents; Chromatography, Liquid; Cycloleucine; Magnetic Resonance Spectroscopy; Mass Spectrometry | 2009 |
Stereo- and Regiocontrolled Syntheses of Exomethylenic Cyclohexane β-Amino Acid Derivatives.
Topics: Amino Acids; Antifungal Agents; beta-Lactams; Cyclohexanes; Cycloleucine; Fungi; Hydroxylation; Molecular Structure; Oxidation-Reduction | 2015 |