Page last updated: 2024-09-04

platycodin d and beta-escin

platycodin d has been researched along with beta-escin in 134 studies

Compound Research Comparison

Studies (platycodin d)	Trials (platycodin d)	Recent Studies (post-2010) (platycodin d)	Studies (beta-escin)	Trials (beta-escin)	Recent Studies (post-2010) (beta-escin)
143	1	112	14,137	211	6,278

Research

Studies (134)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (1.49)	18.2507
2000's	22 (16.42)	29.6817
2010's	76 (56.72)	24.3611
2020's	34 (25.37)	2.80

Authors

Authors	Studies
Arai, I; Hirai, Y; Ida, Y; Komatsu, Y; Kuroiwa, Y; Sasaki, K; Shingu, K; Taguchi, S; Yamamoto, T; Yamaura, H	1
Amagaya, S; Arai, I; Hirai, Y; Ida, Y; Kajimoto, T; Komatsu, Y; Kuroiwa, Y; Kuwahara, N; Miura, T; Sasaki, K; Shingu, K; Taguchi, S; Yamamoto, T	1
Ban, HS; Kim, SY; Kim, YP; Lee, EB; Li, D; Lim, SS; Ohuchi, K; Shin, KH	1
Choi, EY; Ko, KH; Lee, EB; Lee, WJ; Shin, CY	1
Han, LK; Kimura, Y; Okuda, H; Xu, BJ; Zheng, YN	1
Choi, SS; Han, EJ; Han, KJ; Lee, HK; Lee, JK; Lee, TH; Suh, HW	1
Nikaido, T; Saeki, T	1
Kim, BS; Lee, DW; Lee, EB; Levis, WR; Park, E; Park, SY; Schuller Levis, GB; Wang, C	1
Choi, SS; Han, EJ; Han, KJ; Lee, HK; Lee, TH; Suh, HW	1
Kim, YS; Zhao, HL	2
Cho, KH; Ha, YW; Jeong, TS; Kim, YS; Lee, WS; Zhao, HL	1
Ahn, KS; Hahn, BS; Kim, YS; Kwack, K; Lee, EB	1
Guo, L; Li, L; Xiao, YQ; Zhang, C	1
Chang, JH; Hwang, IK; Ji, GE; Kim, YS; Wie, HJ; Zhao, HL	1
Choi, BT; Choi, YH; Kang, HS; Kim, GY; Kim, MO; Lee, JD; Li, W; Moon, DO; Shin, DY	1
Choi, YH; Kim, GY; Kim, MO; Kim, ND; Lee, JD; Moon, DO	1
Deng, W; Li, D; Sun, H; Xie, Y	1
Hirasawa, N; Hong, J; Ishihara, K; Kwak, JH; Lim, SS; Ohuchi, K; Seyama, T; Shin, KH; Zee, O	1
Choi, BT; Choi, YH; Kang, HS; Kim, GY; Kim, ND; Li, W; Shin, DY	1
Cheong, CS; Chung, JW; Ha, YW; Kim, YS; Lee, EB; Noh, EJ; Shin, EM; Sim, JS; Zhao, HL	1
Li, D; Sun, HX; Xie, Y	2
Cai, A; Dong, Q; Geng, H; Liu, S; Ma, X; Sun, Y; Wang, J; Xue, Y; Zhou, H	1
Bae, YS; Choi, JH; Hwang, IK; Kang, IJ; Kim, YS; Lee, CH; Park, OK; Ryu, SY; Won, MH; Yi, JS; Yoo, KY	1
Chung, SI; Kang, R; Kim, YS; Lee, H; Yoon, Y	1
He, SW; Li, D; Sun, HX; Xie, Y	1
Kim, AK; Yu, JS	2
Jia, YF; Qiu, Y; Wang, LG; Yang, DT; Zhang, AD; Zhang, LH; Zhang, YP	1
Bae, S; Kim, YS; Lee, H; Yoon, Y	1
Gimble, J; Greenway, F; Liu, Z; Twiner, EM; Yu, Y	1
Hwang, W; Jung, E; Kim, S; Kim, YS; Lee, J; Park, D	1
Huang, L; Jin, CS; Li, SL	1
Bao, Y; Chen, X; Han, X; Liu, S; Ma, L; Pei, L; Wang, Q; Ye, Y	1
Guo, BF; Han, XH; Liu, S; Ye, YY	1
Ahn, YM; Kang, JS; Kim, SK; Lee, BC	1
Li, W; Liang, J; Wang, H; Wang, Z; Zhao, LC; Zheng, YN	1
Cho, ES; Kim, JW; Kim, TW; Lee, HK; Lim, JH; Park, SJ; Son, HY; Song, IB; Yun, HI	1
An, L; Wen, W; Wu, J; Yang, G; Yuan, J; Zhang, F; Zhu, W	1
Kang, M; Kim, YS; Lee, EJ	1
Chun, J; Joo, EJ; Kang, M; Kim, YS	1
Cho, ES; Jung, JY; Kim, TW; Lee, HK; Lim, JH; Son, HY; Song, IB; Yun, HI	1
Chen, Z; Dai, Q; Ge, YQ; Liu, P; Ma, XQ; Wang, HB; Wu, BH	1
Choi, JH; Chung, YC; Hwang, YP; Jeong, HG; Khanal, T; Kim, HG; Lee, HS; Lee, YC; Nam, MS; Song, GY	1
Chen, W; Sun, L; Wu, Z; Zhan, Q; Zhang, F	1
Guo, B; Han, X; Liu, S; Sun, Z; Ye, Y	1
Chun, J; Kim, YS	1
Du, X; Qin, H; Wang, R; Zhang, Y	1
Cai, M; Lu, Z; Mi, M; Qiu, Y; Wang, L; Xu, H; Yang, L; Zhang, C; Zhou, R	1
Cai, F; Chen, WS; Gao, SH; Jiang, B; Sun, LN; Zhan, Q; Zhang, F	1
Chen, XP; Li, T; Lu, JJ; Wang, YT; Wu, GS; Xu, WS	1
Chen, HZ; Fang, C; Gao, YG; Guan, YY; Liu, HJ; Liu, YR; Lu, Q; Luan, X; Xu, JR; Zhao, M	1
Guo, J; Liu, J; Liu, K; Lu, Z; Mi, M; Xu, H; Yang, J; Zhou, R; Zhou, Y	1
Sun, G; Sun, X; Wang, R; Xu, C; Yuan, G	1
Du, J; Jinfu, Y; Shumin, W; Yang, S; Zhang, T	1
Chang, LL; Chen, XP; Chen, Y; Li, T; Lu, JJ; Tang, ZH; Wang, YF; Wang, YT; Wu, GS; Xu, WS; Zhu, H	1
Dai, X; Ding, H; Qiao, Y; Shi, X; Wan, G; Yin, Q	1
Lu, W; Meng, Y; Qian, F; Wang, W; Wang, X; Wang, Y; Yang, Y; Zhang, Z	1
Chen, T; Chen, Y; Gao, J; Ji, H; Ji, J; Lan, L; Wang, S; Wei, Y; Wu, H; Xiang, P; Xiao, W; Xie, P; Yan, T	1
Di, LQ; Du, LN; Kang, A; Shan, JJ; Shen, CS; Wang, SC; Xie, T; Xu, JY; Zhou, W; Zou, JS	1
Chen, Y; Duan, J; Guo, S; Su, Q; Tao, W; Wang, H; Wang, S	1
Anbari, F; Ebrahimi, L; Fesahat, F; Halvaei, I; Zare-Zardini, H	1
Chung, WY; Kang, EJ; Kim, HJ; Kim, KR; Kim, YL; Kim, YS; Lee, SK; Park, KK; Yoon, H	1
Chen, YF; Dong, YT; Li, T; Lu, DZ; Lu, JJ; Tang, ZH; Yang, Z; Zhang, JR	1
Chen, XP; Chen, Y; Leung, CH; Li, T; Lu, JJ; Ma, DL; Tang, ZH; Wang, YF; Wang, YT; Xu, XH	1
Khan, M; Ma, T; Maryam, A; Mehmood, T; Zhang, H	1
Li, W; Liu, Y; Tang, S; Tian, YH; Wang, YP; Wang, Z; Zhang, J	1
Li, SL; Qian, DW; Qian, SH; Zhang, W	1
Han, BJ; Lai, SH; Li, W; Liu, YJ; Tang, B; Wan, D; Yao, JH; Zeng, CC; Zhang, C	1
Guo, J; Kong, Y; Liu, J; Lu, ZL; Song, W; Sun, HL; Wang, H; Wang, JJ; Xu, HX; Yang, J; Zhou, R	1
Choi, JH; Chung, YC; Han, Y; Jeong, HG; Jeong, HM; Jin, SW; Kim, EJ; Kim, YA; Lee, GH; Lee, HS; Lee, KY; Lee, YC	1
Qu, Y; Wang, C; Zhou, L	1
Gao, Y; Luo, H; Ren, X; Sun, B; Wang, B; Wang, Z; Xu, M; Zheng, G; Zhu, K	1
Chen, X; Leung, CH; Li, T; Lu, JJ; Ma, DL	1
An, QX; Lu, WH; Lv, DD; Meng, YL; Tang, G; Wang, WM; Wang, X	1
Gao, W; Guo, Y; Yang, H	1
Ho, TJ; Huang, CY; Kuo, WW; Lin, CH; Lin, YC; Padma, VV; Shen, CY; Yao, HT; Yeh, YL	1
Liu, Y; Zhang, Z; Zhao, M; Zheng, W	1
Chen, X; Dai, XY; Huang, ZJ; Jiang, HL; Li, T; Lu, JJ; Ouyang, DF; Wei, B; Weng, QJ; Yan, R; Zhu, H	1
Fu, Y; Shi, M; Wang, J; Wang, Y; Wei, Z; Yang, Z; Zhang, X; Zhang, Y	1
Hu, JG; Qi, CH; Wang, MS; Wu, JT; Yang, GW; Zhou, L	1
Kim, J; Kim, N; Kim, YS; Kwon, J; Lee, D; Lee, H; Lee, JH; Woo, MH	1
Di, L; Ji, J; Kang, A; Mao, Y; Peng, L; Shan, J; Shen, C; Wu, H; Xie, T; Xu, J	1
Dai, Q; Ge, YQ	1
Chang, RL; Cheng, YC; Huang, CY; Kuo, WW; Lin, YC; Lin, YM; Padma, VV; Shen, CY	1
Che, J; Shi, G; Tang, J; Wang, Y; Zhao, H	1
Ahn, HJ; Ji, GE; Johnston, TV; Ku, S; Park, MS; You, HJ	1
Chen, C; Fu, CL; He, YF; Leng, J; Li, W; Liu, Y; Wang, Z; Zhang, J	1
Chen, C; Cheng, H; Ju, W; Li, X; Li, Z; Liu, Y; Luo, Q; Qi, K; Qiao, J; Sun, Z; Tang, K; Wei, G; Wu, X; Wu, Y; Xu, K; Xu, M; Yan, Z; Zeng, L; Zhu, F	1
Chen, J; Chen, W; Du, T; Duan, M; Liu, Y; Long, F; Sun, Y; Yang, X; Zhang, G; Zhang, M; Zhou, EM	1
Ding, J; Liu, S; Pei, L; Sun, C; Wu, C; Ye, Y	1
Ahn, KS; Jung, Y; Kim, HL; Park, J; Um, JY	1
Kang, SH; Kim, TH; Ko, YJ; Oh, DK; Shin, KC	1
Choi, JH; Chung, YC; Han, Y; Jeong, HG; Jin, SW; Lee, GH; Lee, HS; Lee, KY	1
Guo, H; Wang, G; Wang, X	1
Ardoy, M; Ceña-Diez, R; de la Mata, FJ; Gómez-Ramirez, R; Martin-Moreno, A; Muñoz, E; Muñoz-Fernández, MÁ	1
Chen, X; Chen, YC; Cui, G; Huang, MY; Huang, RY; Jiang, XM; Liu, B; Lu, JJ; Wang, Y; Xu, YL; Yuan, LW	1
Chen, Y; Ma, H; Wang, M; Wu, D; Zhang, W	1
Fan, JY; Lou, Y; Peng, Y; Xiong, J; Zhu, Y	1
Cheng, ML; Cheng, Z; Cong, S; Fan, LD; Hu, YX; Lei, Y; Liu, YM; Mu, M; Yu, L; Zhang, BF; Zhao, XK; Zhu, LL	1
Li, Q; Shi, C; Zhang, X	1
Kim, DW; Kim, YS; Oh, DK; Shin, KC; Woo, HS	1
Bailly, C; Vergoten, G	1
Hu, JN; Leng, J; Li, HP; Li, W; Li, XD; Liu, Y; Shen, Q; Wang, SH; Wang, YP; Wang, Z	1
Chen, D; Chen, T; Dong, L; Guo, Y; Lu, C; Wang, C	2
Cheon, C; Choi, YJ; Kang, SJ; Kim, HI; Kim, TY; Ko, SG; Lee, HJ; Lee, SJ	1
Choi, YH	1
Guo, J; Liu, Y; Song, N; Zhang, J	1
Chen, MC; Chen, RJ; Day, CH; Hsu, WC; Huang, CY; Li, CC; Padma, VV; Ramesh, S; Shibu, MA; Tseng, YC; Wang, TF	1
Hong, LL; Hou, HH; Huang, HF; Su, CC; Tang, YF	1
Guo, R; Li, F; Meng, Q; Wang, B	1
DU, GJ; Geng, SN; Wang, YH; Xu, YW	1
Huang, D; Pei, C; Wang, F; Wang, X; Wang, Z; Wu, Y; Xiao, W	1
Choi, YJ; Kim, HI; Kim, TY; Ko, SG; Lee, SJ; Moon, HE; Paek, SH	1
Gotina, L; Han, S; Jang, MW; Jang, Y; Jeon, S; Ju, YH; Kim, S; Kim, TY; Lee, CJ; Pae, AN; Park, MG; Won, J; Won, W	1
Gao, S; Li, XG; Sun, S; Yang, WS	1
Deng, B; Sun, M	1
Han, Z; He, Y; Sun, H; Zhu, L	1
Li, Q; Li, Y; Liu, Y; Sun, X; Xie, J; Yang, T; Zhang, Y; Zhang, Z; Zhao, S; Zheng, Q	1
Chen, G; Huang, J; Liu, S; Su, J; Wang, J	1
An, SE; Chung, WY; Jung, MJ; Kim, KR; Lee, SK; Park, J; Park, KK; Son, JA; Son, SH; Yang, HJ	1
Cao, XW; Lei, J; Long, MY; Wang, FJ; Zhao, J	1
Cha, HJ; Chang, YC; Choi, YH; Han, M; Hong, SH; Hyun, JW; Jeong, JW; Kim, GY; Kim, HS; Lee, H; Leem, SH; Park, C; Song, KS	1
Cheng, K; Guo, Y; Li, J; Lu, T; Lu, W; Qi, R; Qiu, Y; Wang, S; Xie, Z; Xin, Y; Yang, H; Yang, X; Zheng, S	1
Iida, O; Matsuda, K; Ozaki, K; Shibano, M; Tanaka, Y	1
Chen, C; Hu, JN; Hu, RY; Li, MH; Li, W; Liu, W; Shen, Q; Wang, Z; Xie, LY; Zhang, JT	1
Jiang, L; Jiang, X; Li, Y; Lin, Y; Liu, P; Lu, Y; Xia, T; Zhao, M	1
Huang, Y; Li, L; Li, P; Wang, J; Zeng, J	1
Chu, T; Feng, Z; Liu, J; Liu, Y; Lv, Y; Wan, X; Wang, W; Wang, Y; Yi, B	1
Jiang, L; Jiang, X; Li, Y; Lin, Y; Lu, Y; Pei, R; Ye, P; Zhao, M	1
Jiang, Z; Liu, S; Pei, L; Wu, C; Xie, Y; Ye, Y	1
Jia, X; Ma, J; Wang, X; Xing, Y; Yu, J; Zhang, M; Zhang, Y	1

Reviews

5 review(s) available for platycodin d and beta-escin

Article	Year
[Evaluations of saponin properties of HPLC analysis of Platycodon grandiflorum A.DC]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2003, Volume: 123, Issue:6 Topics: China; Chromatography, High Pressure Liquid; Japan; Korea; Plants, Medicinal; Platycodon; Quality Control; Saponins; Triterpenes	2003
[Advances in studies on Platycodon grandiflorum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2007, Volume: 32, Issue:3 Topics: Animals; Cough; Drugs, Chinese Herbal; Humans; Molecular Structure; Pharyngitis; Phytotherapy; Platycodon; Saponins; Triterpenes	2007
Killing cancer with platycodin D through multiple mechanisms. Journal of cellular and molecular medicine, 2016, Volume: 20, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Survival; Cell Transformation, Neoplastic; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Saponins; Triterpenes	2016
Proposed mechanisms for the extracellular release of PD-L1 by the anticancer saponin platycodin D. International immunopharmacology, 2020, Volume: 85 Topics: Animals; Antineoplastic Agents; B7-H1 Antigen; Cell Membrane; Cholesterol; Humans; Micelles; Saponins; Toll-Like Receptor 4; Triterpenes	2020
Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review. Current drug metabolism, 2022, Volume: 23, Issue:1 Topics: Biotransformation; Cough; Humans; Saponins; Triterpenes	2022

Trials

1 trial(s) available for platycodin d and beta-escin

Article	Year
Pharmacokinetic pilot study of the antiangiogenic activity of standardized platycodi radix. Advances in therapy, 2011, Volume: 28, Issue:10 Topics: Adipose Tissue; Adult; Angiogenesis Inhibitors; Anti-Obesity Agents; Campanulaceae; Dietary Supplements; Dose-Response Relationship, Drug; Humans; Middle Aged; Obesity; Phytotherapy; Pilot Projects; Plant Extracts; Saponins; Triterpenes	2011

Other Studies

128 other study(ies) available for platycodin d and beta-escin

Article	Year
Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats. Planta medica, 1997, Volume: 63, Issue:5 Topics: Animals; Atropine; Cholecystokinin; Duodenum; Esters; Gabexate; Glycyrrhizic Acid; Guanidines; Japan; Male; Pancreas; Pancreatic Juice; Plant Extracts; Plant Roots; Plants, Medicinal; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Saponins; Triterpenes; Trypsin; Trypsin Inhibitors	1997
Requirement of the glycosyl parts in platycodin D to stimulate pancreatic exocrine secretion. Bioorganic & medicinal chemistry letters, 1998, Aug-18, Volume: 8, Issue:16 Topics: Animals; Carbohydrate Conformation; Carbohydrate Sequence; Molecular Sequence Data; Molecular Structure; Pancreas; Plant Roots; Plants, Medicinal; Rats; Saponins; Structure-Activity Relationship; Triterpenes	1998
Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum. Planta medica, 2001, Volume: 67, Issue:4 Topics: Animals; Arachidonic Acid; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Drugs, Chinese Herbal; Enzyme Induction; Indomethacin; Isoenzymes; Macrophages, Peritoneal; Membrane Proteins; Oleanolic Acid; Plant Roots; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rats; Rats, Sprague-Dawley; Saponins; Tetradecanoylphorbol Acetate; Triterpenes	2001
Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters. Planta medica, 2002, Volume: 68, Issue:3 Topics: Animals; Campanulaceae; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mucins; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Respiratory Mucosa; Saponins; Trachea; Triterpenes	2002
Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice. The Journal of nutrition, 2002, Volume: 132, Issue:8 Topics: Animals; Campanulaceae; Dietary Fats; Disease Models, Animal; Fatty Liver; Female; Lipase; Mice; Mice, Inbred ICR; Obesity; Plant Extracts; Saponins; Triglycerides; Triterpenes	2002
Antinociceptive mechanisms of platycodin D administered intracerebroventricularly in the mouse. Planta medica, 2002, Volume: 68, Issue:9 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Analgesics; Animals; Baclofen; Carbohydrate Sequence; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; Injections, Intraventricular; Injections, Spinal; Male; Methysergide; Mice; Mice, Inbred ICR; Molecular Sequence Data; Muscimol; Naloxone; Narcotic Antagonists; Pain Measurement; Plant Extracts; Platycodon; Receptors, Cholecystokinin; Receptors, N-Methyl-D-Aspartate; Saponins; Serotonin Antagonists; Sincalide; Tail; Triterpenes; Yohimbine	2002
Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells. International immunopharmacology, 2004, Volume: 4, Issue:8 Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Line; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Plant Roots; Platycodon; Saponins; Time Factors; Triterpenes; Tumor Necrosis Factor-alpha	2004
Antinociceptive profiles of platycodin D in the mouse. The American journal of Chinese medicine, 2004, Volume: 32, Issue:2 Topics: Animals; Campanulaceae; Cerebral Ventricles; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Saponins; Tail; Triterpenes	2004
Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1,2-diglyceride-based colorimetric assay. Archives of pharmacal research, 2004, Volume: 27, Issue:9 Topics: Colorimetry; Diglycerides; Enzyme Inhibitors; Lipase; Pancreas; Plant Extracts; Plant Roots; Platycodon; Saponins; Triterpenes	2004
Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1,2-diglyceride-based colorimetric assay. Archives of pharmacal research, 2004, Volume: 27, Issue:10 Topics: Anti-Obesity Agents; Carbohydrate Sequence; Colorimetry; Enzyme Inhibitors; Hypolipidemic Agents; Indicators and Reagents; Kinetics; Molecular Sequence Data; Pancrelipase; Reproducibility of Results; Saponins; Triterpenes	2004
Cholesterol-lowering effect of platycodin D in hypercholesterolemic ICR mice. European journal of pharmacology, 2006, May-10, Volume: 537, Issue:1-3 Topics: Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Eating; Feces; Hypercholesterolemia; Liver; Male; Mice; Mice, Inbred ICR; Saponins; Triglycerides; Triterpenes; Weight Gain	2006
Platycodin D-induced apoptosis through nuclear factor-kappaB activation in immortalized keratinocytes. European journal of pharmacology, 2006, May-10, Volume: 537, Issue:1-3 Topics: Animals; Apoptosis; Caspase 3; Caspase 8; Caspases; Cell Line; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Fas Ligand Protein; fas Receptor; Gene Expression Regulation; Humans; I-kappa B Kinase; In Situ Nick-End Labeling; Keratinocytes; Membrane Glycoproteins; Mice; NF-kappa B; RNA, Messenger; Saponins; Triterpenes; Tumor Necrosis Factors	2006
Enzymatic modification of saponins from Platycodon grandiflorum with Aspergillus niger. Journal of agricultural and food chemistry, 2007, Oct-31, Volume: 55, Issue:22 Topics: Animals; Aspergillus niger; Cell Line; Cell Survival; Cricetinae; Cricetulus; Glycoside Hydrolases; Hemolysis; Mice; Mice, Inbred ICR; Platycodon; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes	2007
Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells. Cancer letters, 2008, Mar-08, Volume: 261, Issue:1 Topics: Active Transport, Cell Nucleus; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Humans; Leukemia; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Saponins; Telomerase; Triterpenes	2008
Platycodin D induces mitotic arrest in vitro, leading to endoreduplication, inhibition of proliferation and apoptosis in leukemia cells. International journal of cancer, 2008, Jun-15, Volume: 122, Issue:12 Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Leukemia; Microscopy, Fluorescence; Mitosis; Proto-Oncogene Proteins c-bcl-2; Saponins; Triterpenes; Tubulin	2008
Platycodin D2 is a potential less hemolytic saponin adjuvant eliciting Th1 and Th2 immune responses. International immunopharmacology, 2008, Volume: 8, Issue:8 Topics: Adjuvants, Immunologic; Animals; Antibodies; Antibody Formation; Cell Proliferation; Cytokines; Female; Hemolysis; Immunity, Cellular; Immunization; Lymphocyte Activation; Mice; Ovalbumin; Saponins; Th1 Cells; Th2 Cells; Transcription Factors; Triterpenes	2008
Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea. Inflammation & allergy drug targets, 2008, Volume: 7, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dinoprostone; Drug Evaluation, Preclinical; Furocoumarins; Isoflavones; Korea; Lactones; Lignans; Macrophages, Peritoneal; Medicine, East Asian Traditional; Phytotherapy; Quercetin; Rats; Saponins; Triterpenes	2008
Implication of intracellular ROS formation, caspase-3 activation and Egr-1 induction in platycodon D-induced apoptosis of U937 human leukemia cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2009, Volume: 63, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Early Growth Response Protein 1; Humans; Lymphoma, Large B-Cell, Diffuse; Medicine, East Asian Traditional; Membrane Potential, Mitochondrial; Plant Roots; Platycodon; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Saponins; Triterpenes; U937 Cells	2009
Anti-inflammatory activity of prosapogenin methyl ester of platycodin D via nuclear factor-kappaB pathway inhibition. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:11 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Blotting, Western; Cyclooxygenase 2; Dinoprostone; Edema; Electrophoretic Mobility Shift Assay; Genes, Reporter; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Molecular Structure; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Platycodon; Reverse Transcriptase Polymerase Chain Reaction; Saponins; Transfection; Triterpenes	2008
Platycodin D is a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigen. Vaccine, 2009, Jan-29, Volume: 27, Issue:5 Topics: Adjuvants, Immunologic; Alum Compounds; Animals; Cell Proliferation; Cytokines; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Antigens; Hepatitis B Vaccines; Immunoglobulin G; Killer Cells, Natural; Mice; Platycodon; Saponins; Spleen; T-Lymphocytes; T-Lymphocytes, Cytotoxic; Triterpenes; Vaccines, Synthetic	2009
[Dynamic research of density on Platycodon grandiflorum dry material accumulation and platycodin D content in Platycodon grandiflorum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:1 Topics: Plant Structures; Platycodon; Saponins; Seasons; Triterpenes	2009
Platycodin D and 2''-O-acetyl-polygalacin D2 isolated from Platycodon grandiflorum protect ischemia/reperfusion injury in the gerbil hippocampus. Brain research, 2009, Jul-07, Volume: 1279 Topics: Animals; Brain Ischemia; Cell Survival; Cyclooxygenase 2; Gerbillinae; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Male; Neuroprotective Agents; NF-kappa B; Oleanolic Acid; Phytotherapy; Plant Extracts; Platycodon; Reperfusion Injury; Saponins; Superoxide Dismutase; Superoxide Dismutase-1; Triterpenes	2009
Platycodin D inhibits adipogenesis of 3T3-L1 cells by modulating Kruppel-like factor 2 and peroxisome proliferator-activated receptor gamma. Phytotherapy research : PTR, 2010, Volume: 24 Suppl 2 Topics: 3T3-L1 Cells; Adipogenesis; Animals; Gene Expression Regulation; Kruppel-Like Transcription Factors; Lipid Metabolism; Mice; PPAR gamma; RNA, Messenger; Saponins; Triglycerides; Triterpenes	2010
Platycodin D2 improves specific cellular and humoral responses to hepatitis B surface antigen in mice. Chemistry & biodiversity, 2010, Volume: 7, Issue:1 Topics: Adjuvants, Immunologic; Animals; Cytokines; Hepatitis B Surface Antigens; Immunoglobulin G; Mice; Plant Roots; Platycodon; Saponins; Th1 Cells; Th2 Cells; Triterpenes	2010
Platycodin d improves the immunogenicity of newcastle disease virus-based recombinant avian influenza vaccine in mice. Chemistry & biodiversity, 2010, Volume: 7, Issue:3 Topics: Adjuvants, Immunologic; Animals; Antibodies, Viral; Birds; Hemagglutinin Glycoproteins, Influenza Virus; Influenza A Virus, H5N1 Subtype; Influenza in Birds; Influenza Vaccines; Mice; Newcastle disease virus; Plant Roots; Platycodon; Recombinant Proteins; Saponins; Triterpenes	2010
Platycodin D induces apoptosis in MCF-7 human breast cancer cells. Journal of medicinal food, 2010, Volume: 13, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Caspase 8; Caspase 9; Cell Line, Tumor; Female; Humans; Mitochondria; Mitogen-Activated Protein Kinases; Phytotherapy; Plant Extracts; Plant Roots; Platycodon; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Receptors, Death Domain; Saponins; Triterpenes	2010
[Mechanism for sperm immobilization activity of extract from Platycodon grandiflorum in vitro]. Zhonghua yi xue za zhi, 2010, Nov-30, Volume: 90, Issue:44 Topics: Adult; Cell Membrane; Humans; Male; Plant Extracts; Platycodon; Saponins; Spermatocidal Agents; Spermatozoa; Triterpenes	2010
WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D, a natural compound found in Platycodon grandiflorum. Life sciences, 2011, Sep-12, Volume: 89, Issue:11-12 Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Animals; beta Catenin; Cell Culture Techniques; Mice; Phytotherapy; Plant Roots; Platycodon; RNA; RNA, Small Interfering; Saponins; Transfection; Triterpenes; Up-Regulation; Wnt Proteins	2011
Depigmenting action of platycodin D depends on the cAMP/Rho-dependent signalling pathway. Experimental dermatology, 2011, Volume: 20, Issue:12 Topics: ADP Ribose Transferases; Amides; Apoptosis; Botulinum Toxins; cdc42 GTP-Binding Protein; Cell Shape; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dendrites; Epidermal Cells; Humans; Intramolecular Oxidoreductases; Melanins; Melanocytes; Membrane Glycoproteins; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Oxidoreductases; Pyridines; rac GTP-Binding Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; Saponins; Signal Transduction; Skin Pigmentation; Triterpenes	2011
[Study on industrialization production technology of decoction pieces shuangfei of Platycodon grandiflorum]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2011, Volume: 34, Issue:6 Topics: Drug Industry; Plant Roots; Platycodon; Polysaccharides; Quality Control; Saponins; Technology, Pharmaceutical; Triterpenes	2011
A sensitive method for determination of platycodin d in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. Planta medica, 2012, Volume: 78, Issue:3 Topics: Animals; Chromatography, Liquid; Male; Plant Extracts; Platycodon; Rats; Saponins; Tandem Mass Spectrometry; Triterpenes	2012
[Effects of platycodin D in combination with different active ingredients of Chinese herbs on proliferation and invasion of 4T1 and MDA-MB-231 breast cancer cell lines]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2012, Volume: 10, Issue:1 Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coumarins; Drug Synergism; Drugs, Chinese Herbal; Female; Humans; Neoplasm Invasiveness; Ophiopogon; Saponins; Sesquiterpenes; Triterpenes	2012
Platycodon grandiflorum modifies adipokines and the glucose uptake in high-fat diet in mice and L6 muscle cells. The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:5 Topics: Adipocytes; Adipokines; Adiponectin; Animals; Blood Glucose; Body Weight; Cell Line; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diet, High-Fat; Energy Intake; Fructosamine; Gene Expression; Glucose; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Leptin; Male; Mice; Mice, Inbred ICR; Muscle Cells; Obesity; Phytotherapy; Plant Extracts; Platycodon; Resistin; Saponins; Triglycerides; Triterpenes; Tumor Necrosis Factor-alpha	2012
Response surface methodology to optimize enzymatic preparation of Deapio-Platycodin D and Platycodin D from Radix Platycodi. International journal of molecular sciences, 2012, Volume: 13, Issue:4 Topics: Hydrolysis; Medicine, Chinese Traditional; Models, Statistical; Oleanolic Acid; Plant Extracts; Plant Roots; Platycodon; Saponins; Triterpenes	2012
Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:12 Topics: Animals; Apoptosis; Blood Urea Nitrogen; Cisplatin; Creatinine; Glutathione; Glutathione Peroxidase; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide; Oxidative Stress; Plant Roots; Platycodon; Saponins; Superoxide Dismutase; Triterpenes	2012
Platycodin D induces reactive oxygen species-mediated apoptosis signal-regulating kinase 1 activation and endoplasmic reticulum stress response in human breast cancer cells. Journal of medicinal food, 2012, Volume: 15, Issue:8 Topics: Breast Neoplasms; Cell Line, Tumor; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Activation; Female; Humans; MAP Kinase Kinase Kinase 5; Mitogen-Activated Protein Kinases; Plant Extracts; Platycodon; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes	2012
Anti-atherosclerotic activity of platycodin D derived from roots of Platycodon grandiflorum in human endothelial cells. Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:8 Topics: Atherosclerosis; Cell Adhesion; Cell Adhesion Molecules; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Malondialdehyde; Monocytes; Nitric Oxide; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Roots; Platycodon; RNA, Messenger; Saponins; Triterpenes; Vascular Cell Adhesion Molecule-1	2012
Platycodin D inhibits lipogenesis through AMPKα-PPARγ2 in 3T3-L1 cells and modulates fat accumulation in obese mice. Planta medica, 2012, Volume: 78, Issue:14 Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Body Weight; Cell Differentiation; Diet, High-Fat; Hypoglycemic Agents; Lipogenesis; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Molecular Structure; Obesity, Abdominal; Plant Roots; Platycodon; PPAR gamma; Ribonucleotides; Saponins; Signal Transduction; Triterpenes	2012
Platycodin D induces anoikis and caspase-mediated apoptosis via p38 MAPK in AGS human gastric cancer cells. Journal of cellular biochemistry, 2013, Volume: 114, Issue:2 Topics: Anoikis; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Humans; Imidazoles; Mitochondria; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Saponins; Signal Transduction; Stomach Neoplasms; Transcription Factor AP-1; Triterpenes	2013
Platycodin D attenuates bile duct ligation-induced hepatic injury and fibrosis in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 51 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Ducts; Bilirubin; Cholestasis; Disease Models, Animal; Fibrosis; Glutathione; Ligation; Liver; Male; Mice; Mice, Inbred ICR; NF-kappa B; Oxidative Stress; Protective Agents; Saponins; Superoxide Dismutase; Triterpenes	2013
[Mechanism of platycodin D-induced apoptosis in A549 human lung cancer cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012, Volume: 37, Issue:17 Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation; Drugs, Chinese Herbal; Gene Expression; Humans; Lung Neoplasms; Saponins; Triterpenes	2012
Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells. Toxicology and applied pharmacology, 2013, Mar-01, Volume: 267, Issue:2 Topics: AMP-Activated Protein Kinases; Animals; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Diet, High-Fat; Fatty Acid Synthases; Glucose; Hep G2 Cells; Humans; Lipogenesis; Liver; Male; Platycodon; Rats; Rats, Sprague-Dawley; Saponins; Sirtuin 1; Sterol Regulatory Element Binding Protein 1; Triterpenes	2013
Two new oleanane-type triterpenoids from Platycodi Radix and anti-proliferative activity in HSC-T6 cells. Molecules (Basel, Switzerland), 2012, Dec-13, Volume: 17, Issue:12 Topics: Animals; Cell Line; Cell Proliferation; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Roots; Platycodon; Rats; Saponins; Triterpenes	2012
Combination treatment with platycodin D and osthole inhibits cell proliferation and invasion in mammary carcinoma cell lines. Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:1 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Coumarins; Gene Expression Regulation, Neoplastic; Humans; Mice; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Saponins; Smad Proteins; Transforming Growth Factor beta; Triterpenes	2013
Platycodin D inhibits migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways. Chemico-biological interactions, 2013, Oct-05, Volume: 205, Issue:3 Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; ErbB Receptors; Female; Humans; Immunohistochemistry; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; NF-kappa B; Random Allocation; Real-Time Polymerase Chain Reaction; RNA, Neoplasm; Saponins; Triterpenes; Xenograft Model Antitumor Assays	2013
Platycodin D, a triterpenoid saponin from Platycodon grandiflorum, induces G2/M arrest and apoptosis in human hepatoma HepG2 cells by modulating the PI3K/Akt pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:2 Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Elafin; G2 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; Liver Neoplasms; Platycodon; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Triterpenes	2014
Evaluation of the spermicidal and contraceptive activity of Platycodin D, a Saponin from Platycodon grandiflorum. PloS one, 2013, Volume: 8, Issue:11 Topics: Adult; Animals; Cell Survival; Comet Assay; Contraception; Female; Humans; Male; Mucous Membrane; Platycodon; Rats; Saponins; Sperm Motility; Spermatocidal Agents; Spermatozoa; Triterpenes; Vagina; Young Adult	2013
An HPLC-MS/MS method for the quantitative determination of platycodin D in rat plasma and its application to the pharmacokinetics of Platycodi Radix extract. Chinese journal of natural medicines, 2014, Volume: 12, Issue:2 Topics: Administration, Oral; Animals; Biological Availability; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Male; Plant Roots; Platycodon; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry; Triterpenes	2014
Platycodin D induces apoptosis, and inhibits adhesion, migration and invasion in HepG2 hepatocellular carcinoma cells. Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:4 Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Hep G2 Cells; Humans; Inhibitor of Apoptosis Proteins; Liver Neoplasms; Medicine, Chinese Traditional; Neoplasm Invasiveness; Plant Extracts; Poly(ADP-ribose) Polymerases; Saponins; Survivin; Tetradecanoylphorbol Acetate; Triterpenes; Up-Regulation	2014
Platycodin D inhibits tumor growth by antiangiogenic activity via blocking VEGFR2-mediated signaling pathway. Toxicology and applied pharmacology, 2014, 11-15, Volume: 281, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Campanulaceae; Cell Line, Tumor; Cell Survival; Chick Embryo; Chorioallantoic Membrane; Dose-Response Relationship, Drug; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Saponins; Signal Transduction; Triterpenes; Tumor Burden; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays	2014
Platycodin D induces tumor growth arrest by activating FOXO3a expression in prostate cancer in vitro and in vivo. Current cancer drug targets, 2015, Volume: 14, Issue:9 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line; Dose-Response Relationship, Drug; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Mice, Nude; Neoplasm Proteins; Prostate; Prostatic Neoplasms; Proto-Oncogene Proteins c-mdm2; Random Allocation; Recombinant Proteins; Resting Phase, Cell Cycle; Saponins; Specific Pathogen-Free Organisms; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays	2015
Effects of platycodin D on proliferation, apoptosis and PI3K/Akt signal pathway of human glioma U251 cells. Molecules (Basel, Switzerland), 2014, Dec-19, Volume: 19, Issue:12 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Glioma; Humans; Inhibitory Concentration 50; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Triterpenes	2014
Platycodin D Attenuates Airway Inflammation in a Mouse Model of Allergic Asthma by Regulation NF-κB Pathway. Inflammation, 2015, Volume: 38, Issue:3 Topics: Airway Resistance; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Campanulaceae; Dexamethasone; Disease Models, Animal; Eosinophilia; Eosinophils; Female; I-kappa B Kinase; I-kappa B Proteins; Interleukin-13; Interleukin-4; Interleukin-5; Lung; Mice; Mice, Inbred BALB C; NF-KappaB Inhibitor alpha; Ovalbumin; Plant Extracts; Random Allocation; Saponins; Transcription Factor RelA; Triterpenes	2015
Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells. European journal of pharmacology, 2015, Feb-15, Volume: 749 Topics: Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Chloroquine; Extracellular Signal-Regulated MAP Kinases; Humans; Liver Neoplasms; Macrolides; Saponins; Triterpenes	2015
Solubilization of menthol by platycodin D in aqueous solution: an integrated study of classical experiments and dissipative particle dynamics simulation. International journal of pharmaceutics, 2015, Mar-01, Volume: 480, Issue:1-2 Topics: Computer Simulation; Drug Delivery Systems; Drug Synergism; Medicine, Chinese Traditional; Mentha; Menthol; Platycodon; Saponins; Solubility; Temperature; Triterpenes	2015
The inhibition of Platycodin D on Mycoplasma pneumoniae proliferation and its effect on promoting cell growth after anti-Mycoplasma pneumoniae treatment. Frontiers in cellular and infection microbiology, 2014, Volume: 4 Topics: Animals; Cell Proliferation; Drugs, Chinese Herbal; Humans; Mice; Mice, Inbred BALB C; Mycoplasma pneumoniae; Plant Roots; Platycodon; Pneumonia, Mycoplasma; Saponins; Triterpenes	2014
Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance. International immunopharmacology, 2015, Volume: 26, Issue:2 Topics: Alanine Transaminase; Alloxan; Animals; Aspartate Aminotransferases; Blood Glucose; Chemical and Drug Induced Liver Injury; Cholesterol; Codonopsis; Cytokines; Diabetes Mellitus, Experimental; Forkhead Transcription Factors; Inflammation Mediators; Insulin; Liver; Mice; Mice, Inbred Strains; Saponins; STAT3 Transcription Factor; T-Lymphocytes, Regulatory; Th17 Cells; Triterpenes	2015
Effects of Gancao on pharmacokinetic profiles of platycodin D and deapio-platycodin D in Jiegeng. Journal of ethnopharmacology, 2015, Jul-21, Volume: 170 Topics: Animals; Area Under Curve; Caco-2 Cells; Chromatography, Liquid; Drugs, Chinese Herbal; Glycyrrhiza; Half-Life; Humans; Intestinal Absorption; Male; Plant Extracts; Plant Roots; Platycodon; Rats; Rats, Sprague-Dawley; Rhizome; Saponins; Tandem Mass Spectrometry; Triterpenes	2015
Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro. International immunopharmacology, 2015, Volume: 27, Issue:1 Topics: Acute Lung Injury; Animals; Apoptosis; Bleomycin; Cell Line; Female; Humans; Immunosuppressive Agents; Interleukin-6; Lipopolysaccharides; Mice; Mice, Inbred BALB C; NF-kappa B; Platycodon; Pneumonia; Proto-Oncogene Proteins c-bcl-2; Saponins; Triterpenes; Tumor Necrosis Factor-alpha	2015
Assessment of spermicidal activity of the antimicrobial peptide sarcotoxin Pd: A potent contraceptive agent. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 2016, Volume: 21, Issue:1 Topics: Adult; Anti-Bacterial Agents; Contraceptive Agents, Male; Humans; Male; Reference Values; Saponins; Sperm Motility; Spermatocidal Agents; Spermatozoa; Triterpenes	2016
Platycodin D Blocks Breast Cancer-Induced Bone Destruction by Inhibiting Osteoclastogenesis and the Growth of Breast Cancer Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 36, Issue:5 Topics: Animals; Apoptosis; Bone and Bones; Breast Neoplasms; Cell Division; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Osteoclasts; Saponins; Transcription Factors; Triterpenes	2015
Proteomic analysis of hepatocellular carcinoma HepG2 cells treated with platycodin D. Chinese journal of natural medicines, 2015, Volume: 13, Issue:9 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Campanulaceae; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Hep G2 Cells; Humans; Liver Neoplasms; Phytotherapy; Plant Extracts; Prohibitins; Proteome; Proteomics; Saponins; Triterpenes; Up-Regulation	2015
Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells. Acta pharmacologica Sinica, 2015, Volume: 36, Issue:12 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Female; Humans; Liver; Liver Neoplasms; MAP Kinase Signaling System; Mice, Inbred BALB C; Mice, Nude; Platycodon; Saponins; Triterpenes	2015
Platycodin D exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis. The Journal of toxicological sciences, 2016, Volume: 41, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytokines; Dose-Response Relationship, Drug; Immunologic Factors; Liver Neoplasms; Male; Mice, Inbred ICR; Proto-Oncogene Proteins c-bcl-2; Saponins; Signal Transduction; Time Factors; Triterpenes; Tumor Burden; Vascular Endothelial Growth Factor A	2016
Screening of Intestinal Bacterial Metabolites of Platycodin D Using Ultra-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry. The American journal of Chinese medicine, 2016, Volume: 44, Issue:4 Topics: Animals; Bacteria; Chromatography, High Pressure Liquid; Feces; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; Intestines; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes	2016
Platycodin D induced apoptosis and autophagy in PC-12 cells through mitochondrial dysfunction pathway. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2016, Nov-05, Volume: 168 Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Campanulaceae; Cell Cycle Checkpoints; Cell Line; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neoplasms; PC12 Cells; Rats; Reactive Oxygen Species; Saponins; Triterpenes	2016
Platycodin D, a metabolite of Platycodin grandiflorum, inhibits highly metastatic MDA-MB-231 breast cancer growth in vitro and in vivo by targeting the MDM2 oncogene. Oncology reports, 2016, Volume: 36, Issue:3 Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Female; G1 Phase; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Oncogenes; Proto-Oncogene Proteins c-mdm2; Resting Phase, Cell Cycle; Saponins; Triterpenes; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2016
Platycodin D Inhibits Osteoclastogenesis by Repressing the NFATc1 and MAPK Signaling Pathway. Journal of cellular biochemistry, 2017, Volume: 118, Issue:4 Topics: Animals; Cell Differentiation; Disease Models, Animal; Female; Humans; Macrophages; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Osteogenesis; Osteoporosis, Postmenopausal; Ovariectomy; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; RANK Ligand; RAW 264.7 Cells; Saponins; Signal Transduction; Triterpenes	2017
Effects of platycodin D on IL-1β-induced inflammatory response in human osteoarthritis chondrocytes. International immunopharmacology, 2016, Volume: 40 Topics: Aged; Anti-Inflammatory Agents; Cells, Cultured; Chondrocytes; Dinoprostone; Gene Expression Regulation; Humans; Interleukin-1beta; Liver X Receptors; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Middle Aged; NF-kappa B; Nitric Oxide; Osteoarthritis; Platycodon; RNA, Small Interfering; Saponins; Signal Transduction; Triterpenes	2016
Platycodin D inhibits interleukin-13-induced the expression of inflammatory cytokines and mucus in nasal epithelial cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84 Topics: Anti-Inflammatory Agents; Cell Line; Cytokines; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Inflammation Mediators; Interleukin-13; Mucin 5AC; Nasal Mucosa; Phosphorylation; Saponins; Signal Transduction; Transcription Factor RelA; Triterpenes	2016
Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells. Scientific reports, 2016, 11-29, Volume: 6 Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Feedback, Physiological; Humans; Lung Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Saponins; Triterpenes; Tumor Cells, Cultured	2016
The effect of Platycodin D on the expression of cytoadherence proteins P1 and P30 in Mycoplasma pneumoniae models. Environmental toxicology and pharmacology, 2017, Volume: 49 Topics: A549 Cells; Adhesins, Bacterial; Animals; Anti-Bacterial Agents; Humans; Mice, Inbred BALB C; Mycoplasma pneumoniae; Pneumonia, Mycoplasma; RNA, Messenger; Saponins; Triterpenes	2017
Platycodin D protects against cigarette smoke-induced lung inflammation in mice. International immunopharmacology, 2017, Volume: 47 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cigarette Smoking; Heme Oxygenase-1; Humans; Interleukin-1beta; Lymphotoxin-alpha; Male; Malondialdehyde; Membrane Proteins; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Pneumonia; Pulmonary Disease, Chronic Obstructive; Saponins; Triterpenes	2017
Platycodon grandiflorum (PG) reverses angiotensin II-induced apoptosis by repressing IGF-IIR expression. Journal of ethnopharmacology, 2017, Jun-09, Volume: 205 Topics: Angiotensin II; Animals; Apoptosis; Cell Line; Gene Expression Regulation; Myoblasts; Plant Extracts; Platycodon; Rats; Rats, Inbred WKY; Receptor, IGF Type 2; Saponins; Triterpenes	2017
Platycodin D, a triterpenoid saponin from Platycodon grandiflorum, suppresses the growth and invasion of human oral squamous cell carcinoma cells via the NF-κB pathway. Journal of biochemical and molecular toxicology, 2017, Volume: 31, Issue:9 Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Proteins; Platycodon; Saponins; Signal Transduction; Transcription Factor RelA; Triterpenes; Xenograft Model Antitumor Assays	2017
Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor. Toxicology and applied pharmacology, 2017, 09-01, Volume: 330 Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Proliferation; Chaperonins; ErbB Receptors; Everolimus; HSP90 Heat-Shock Proteins; Humans; Immunosuppressive Agents; Lung Neoplasms; Oncogene Protein v-akt; Receptor, IGF Type 1; Receptors, Somatomedin; Saponins; TOR Serine-Threonine Kinases; Triterpenes	2017
Platycodin D suppressed LPS-induced inflammatory response by activating LXRα in LPS-stimulated primary bovine mammary epithelial cells. European journal of pharmacology, 2017, Nov-05, Volume: 814 Topics: Animals; Cattle; Gene Expression Regulation; Humans; Inflammation; Interleukin-6; Lipopolysaccharides; Liver X Receptors; Mammary Glands, Animal; NF-kappa B; Saponins; Triterpenes	2017
ANTI-INFLAMMATORY ACTIVITY OF PLATYCODIN D ON ALCOHOL-INDUCED FATTY LIVER RATS VIA TLR4-MYD88-NF-κB SIGNAL PATH. African journal of traditional, complementary, and alternative medicines : AJTCAM, 2016, Volume: 13, Issue:4 Topics: Alcohols; Animals; Anti-Inflammatory Agents; Drugs, Chinese Herbal; Fatty Liver; Humans; Interleukin-6; Male; NF-kappa B; Plant Roots; Platycodon; Rats; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes; Tumor Necrosis Factor-alpha	2016
Effect of processing method on platycodin D content in Platycodon grandiflorum roots. Archives of pharmacal research, 2017, Volume: 40, Issue:9 Topics: Asia, Eastern; Chromatography, High Pressure Liquid; Plant Roots; Platycodon; Saponins; Temperature; Triterpenes	2017
Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao. Molecules (Basel, Switzerland), 2017, Sep-21, Volume: 22, Issue:10 Topics: Caco-2 Cells; Chalcone; Flavanones; Flavonoids; Glucosides; Glycyrrhiza uralensis; Humans; Saponins; Triterpenes	2017
[Inhibitory effect and mechanism of platycodin D combined with imatinib on K562/R]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2018, Volume: 43, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Saponins; Signal Transduction; Triterpenes	2018
Platycodin D Reverses Pathological Cardiac Hypertrophy and Fibrosis in Spontaneously Hypertensive Rats. The American journal of Chinese medicine, 2018, Volume: 46, Issue:3 Topics: Animals; Cardiomegaly; Collagen; Disease Models, Animal; Fibrosis; Myocardium; Phytotherapy; Platycodon; Rats, Inbred SHR; Rats, Inbred WKY; Saponins; Triterpenes	2018
Platycodin D inhibits oxidative stress and apoptosis in H9c2 cardiomyocytes following hypoxia/reoxygenation injury. Biochemical and biophysical research communications, 2018, 09-18, Volume: 503, Issue:4 Topics: Animals; Antioxidants; Apoptosis; Campanulaceae; Cardiotonic Agents; Cell Hypoxia; Cell Line; Cell Survival; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Rats; Reactive Oxygen Species; Saponins; Triterpenes	2018
Biocatalysis of Platycoside E and Platycodin D3 Using Fungal Extracellular β-Glucosidase Responsible for Rapid Platycodin D Production. International journal of molecular sciences, 2018, Sep-08, Volume: 19, Issue:9 Topics: Animals; Anti-Inflammatory Agents; Aspergillus; beta-Glucosidase; Biocatalysis; Biotechnology; Biotransformation; Interleukin-6; Lipopolysaccharides; Mice; Oleanolic Acid; Platycodon; RAW 264.7 Cells; Saponins; Triterpenes	2018
Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 107 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Glutathione; Hepatocytes; Inflammation; Liver; Male; Malondialdehyde; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Oxidative Stress; Platycodon; Protective Agents; Saponins; Triterpenes	2018
Platycodin D inhibits platelet function and thrombus formation through inducing internalization of platelet glycoprotein receptors. Journal of translational medicine, 2018, 11-15, Volume: 16, Issue:1 Topics: Animals; Apoptosis; Arteries; Blood Platelets; Clot Retraction; Endocytosis; Hemostasis; Humans; Mice, Inbred C57BL; P-Selectin; Phospholipase C gamma; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Saponins; Signal Transduction; Syk Kinase; Thrombosis; Triterpenes	2018
Platycodin D Suppresses Type 2 Porcine Reproductive and Respiratory Syndrome Virus In Primary and Established Cell Lines. Viruses, 2018, 11-21, Volume: 10, Issue:11 Topics: Animals; Antiviral Agents; Cells, Cultured; Microbial Sensitivity Tests; Porcine respiratory and reproductive syndrome virus; Saponins; Swine; Triterpenes; Virus Internalization; Virus Release; Virus Replication	2018
Effects of Platycodin D on S100A8/A9-induced inflammatory response in murine mammary carcinoma 4T1 cells. International immunopharmacology, 2019, Volume: 67 Topics: Animals; Calgranulin A; Calgranulin B; Cell Line, Tumor; Cell Movement; Cell Survival; Cytokines; Female; Gene Expression Regulation; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Molecular Structure; Neoplasms, Experimental; Saponins; Triterpenes	2019
Platycodin D, a novel activator of AMP-activated protein kinase, attenuates obesity in db/db mice via regulation of adipogenesis and thermogenesis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 52 Topics: 3T3-L1 Cells; Adipocytes, Brown; Adipogenesis; Adipose Tissue, Brown; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; CCAAT-Enhancer-Binding Protein-alpha; Humans; Male; Mesenchymal Stem Cells; Mice; Mice, Knockout; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Platycodon; PPAR gamma; Saponins; Thermogenesis; Triterpenes; Uncoupling Protein 1	2019
Biotransformation of Food-Derived Saponins, Platycosides, into Deglucosylated Saponins Including Deglucosylated Platycodin D and Their Anti-Inflammatory Activities. Journal of agricultural and food chemistry, 2019, Feb-06, Volume: 67, Issue:5 Topics: Anti-Inflammatory Agents; Bacteria; Bacterial Proteins; beta-Glucosidase; Biocatalysis; Biotransformation; Glycosylation; Oleanolic Acid; Plant Extracts; Platycodon; Saponins; Triterpenes	2019
Stimulatory effects of platycodin D on osteoblast differentiation. Journal of cellular biochemistry, 2019, Volume: 120, Issue:8 Topics: Alkaline Phosphatase; Animals; beta Catenin; Biomarkers; Calcification, Physiologic; Cell Differentiation; Cell Line; Collagen Type I; Collagen Type I, alpha 1 Chain; Integrin-Binding Sialoprotein; Mesenchymal Stem Cells; Mice; Molecular Structure; Osteoblasts; Osteogenesis; Saponins; Transcription Factors; Triterpenes; Wnt Signaling Pathway	2019
Platycodin D protects cortical neurons against oxygen-glucose deprivation/reperfusion in neonatal hypoxic-ischemic encephalopathy. Journal of cellular biochemistry, 2019, Volume: 120, Issue:8 Topics: Animals; Animals, Newborn; Apoptosis; Cell Survival; Cerebral Cortex; Glucose; Hypoxia-Ischemia, Brain; Neurons; Neuroprotective Agents; Oxidative Stress; Oxygen; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Reperfusion Injury; Saponins; Signal Transduction; TOR Serine-Threonine Kinases; Triterpenes	2019
G1-S4 or G2-S16 carbosilane dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity. International journal of nanomedicine, 2019, Volume: 14 Topics: Animals; Anti-Infective Agents; Cell Proliferation; Chlorocebus aethiops; Contraceptive Agents; Dendrimers; Female; Herpesvirus 2, Human; Humans; Leukocytes, Mononuclear; Male; Mice, Inbred BALB C; Saponins; Silanes; Sperm Capacitation; Spermatozoa; Toxicity Tests; Triterpenes; Vagina; Vero Cells	2019
Platycodin D triggers the extracellular release of programed death Ligand-1 in lung cancer cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 131 Topics: B7-H1 Antigen; Cell Line, Tumor; Chlorpromazine; Humans; Interleukin-2; Jurkat Cells; Protein Transport; Saponins; Triterpenes	2019
Platycodin D inhibits proliferation, migration and induces chemosensitization through inactivation of the NF-κB and JAK2/STAT3 pathways in multiple myeloma cells. Clinical and experimental pharmacology & physiology, 2019, Volume: 46, Issue:12 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Humans; Janus Kinase 2; Multiple Myeloma; NF-kappa B; Saponins; Signal Transduction; STAT3 Transcription Factor; Triterpenes	2019
miR-34a Enhances the Susceptibility of Gastric Cancer to Platycodin D by Targeting Survivin. Pathobiology : journal of immunopathology, molecular and cellular biology, 2019, Volume: 86, Issue:5-6 Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Mice; Mice, Nude; MicroRNAs; Saponins; Stomach Neoplasms; Survivin; Triterpenes; Xenograft Model Antitumor Assays	2019
Platycodin D alleviates liver fibrosis and activation of hepatic stellate cells by regulating JNK/c-JUN signal pathway. European journal of pharmacology, 2020, Jun-05, Volume: 876 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Cell Proliferation; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Phosphorylation; Saponins; Triterpenes	2020
Platycodin D Protects Human Fibroblast Cells from Premature Senescence Induced by H2O2 through Improving Mitochondrial Biogenesis. Pharmacology, 2020, Volume: 105, Issue:9-10 Topics: Antioxidants; Cell Cycle; Cellular Senescence; DNA-Binding Proteins; Fibroblasts; Humans; Hydrogen Peroxide; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins; Nuclear Respiratory Factors; Organelle Biogenesis; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Saponins; Transcription Factors; Triterpenes	2020
Conversion of Glycosylated Platycoside E to Deapiose-Xylosylated Platycodin D by Cytolase PCL5. International journal of molecular sciences, 2020, Feb-11, Volume: 21, Issue:4 Topics: Glycosylation; Oleanolic Acid; Plant Proteins; Platycodon; Saponins; Triterpenes	2020
Platycodin D suppresses cisplatin-induced cytotoxicity by suppressing ROS-mediated oxidative damage, apoptosis, and inflammation in HEK-293 cells. Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:1 Topics: Apoptosis; Cisplatin; HEK293 Cells; Humans; Inflammation; MAP Kinase Signaling System; Reactive Oxygen Species; Saponins; Triterpenes	2021
Platycodin D (PD) regulates LncRNA-XIST/miR-335 axis to slow down bladder cancer progression in vitro and in vivo. Experimental cell research, 2020, 11-01, Volume: 396, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Epithelial Cells; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Ki-67 Antigen; Mice; Mice, Nude; MicroRNAs; RNA, Long Noncoding; RNA, Small Interfering; Saponins; Signal Transduction; Triterpenes; Tumor Burden; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays	2020
Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells. Scientific reports, 2020, 11-16, Volume: 10, Issue:1 Topics: Cell Line; Cholesterol, LDL; Cycloheximide; Drug Synergism; Gene Expression Regulation; Half-Life; Hep G2 Cells; Hepatocytes; Humans; Plant Roots; Platycodon; Receptors, LDL; Saponins; Simvastatin; Triterpenes; Ubiquitin-Protein Ligases; Ubiquitination	2020
Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of platycodin D against oxidative stress-induced DNA damage and apoptosis in C2C12 myoblasts. General physiology and biophysics, 2020, Volume: 39, Issue:6 Topics: Animals; Apoptosis; Cell Line; DNA Damage; Heme Oxygenase-1; Hydrogen Peroxide; Membrane Proteins; Mice; Myoblasts; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes	2020
Platycodin D Inhibits β-Amyloid-Induced Inflammation and Oxidative Stress in BV-2 Cells Via Suppressing TLR4/NF-κB Signaling Pathway and Activating Nrf2/HO-1 Signaling Pathway. Neurochemical research, 2021, Volume: 46, Issue:3 Topics: Amyloid beta-Peptides; Animals; Cell Line; Cell Survival; Gene Knockdown Techniques; Heme Oxygenase-1; Inflammation; Membrane Proteins; Mice; NF-E2-Related Factor 2; NF-kappa B p50 Subunit; Oxidative Stress; Peptide Fragments; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes	2021
Platycodin D reverses histone deacetylase inhibitor resistance in hepatocellular carcinoma cells by repressing ERK1/2-mediated cofilin-1 phosphorylation. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 82 Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cofilin 1; Cofilin 2; Drug Resistance, Neoplasm; Histone Deacetylase Inhibitors; Humans; Liver Neoplasms; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Phosphorylation; Saponins; Triterpenes	2021
Suppressive effect of platycodin D on bladder cancer through microRNA-129-5p-mediated PABPC1/PI3K/AKT axis inactivation. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2021, Volume: 54, Issue:3 Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Phosphatidylinositol 3-Kinases; Poly(A)-Binding Protein I; Proto-Oncogene Proteins c-akt; Saponins; Triterpenes; Urinary Bladder Neoplasms	2021
Platycodin D alleviates proliferation and extracellular matrix accumulation in TGF-beta1 induced pulmonary fibroblasts. Bratislavske lekarske listy, 2021, Volume: 122, Issue:2 Topics: Actins; Cell Proliferation; Extracellular Matrix; Fibroblasts; Lung; Pulmonary Fibrosis; Saponins; Transforming Growth Factor beta1; Triterpenes	2021
Anti-inflammatory effects of Platycodin D on dextran sulfate sodium (DSS) induced colitis and E. coli Lipopolysaccharide (LPS) induced inflammation. International immunopharmacology, 2021, Volume: 94 Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Cell Survival; Colitis; Colon; Cytokines; Dextran Sulfate; Escherichia coli; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; RAW 264.7 Cells; Saponins; Triterpenes	2021
[Guiding mechanism of platycodin D in treatment of mouse lung cancer with doxorubicin]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2021, Volume: 46, Issue:6 Topics: Animals; Cell Line, Tumor; Doxorubicin; Lung Neoplasms; Mice; Saponins; Triterpenes	2021
Suppression of NLRP3 inflammasome by Platycodin D via the TLR4/MyD88/NF-κB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats. International immunopharmacology, 2021, Volume: 96 Topics: Acute Lung Injury; Animals; Apoptosis Regulatory Proteins; Caspase 1; Cytokines; Down-Regulation; Edema; I-kappa B Proteins; Inflammasomes; Lipopolysaccharides; Macrophages, Alveolar; Myeloid Differentiation Factor 88; Neoplasm Proteins; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Nucleocytoplasmic Transport Proteins; Organ Size; Oxidative Stress; Rats, Sprague-Dawley; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes	2021
Platycodin D inhibits autophagy and increases glioblastoma cell death via LDLR upregulation. Molecular oncology, 2022, Volume: 16, Issue:1 Topics: Autophagy; Cell Death; Cholesterol; Glioblastoma; Humans; Lysosomes; Receptors, LDL; Saponins; Triterpenes; Up-Regulation	2022
Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion. Experimental & molecular medicine, 2021, Volume: 53, Issue:5 Topics: Antiviral Agents; Cell Line; COVID-19; COVID-19 Drug Treatment; Humans; Lysosomes; Models, Molecular; Platycodon; Saponins; SARS-CoV-2; Serine Endopeptidases; Triterpenes; Virus Internalization	2021
Investigation of the Inhibitory Effect of Platycodin D in Human Transitional Cell Carcinoma Cell Line 5637. Folia biologica, 2021, Volume: 67, Issue:1 Topics: Animals; Apoptosis; Carcinoma, Transitional Cell; Cell Line, Tumor; Humans; Mice; Mice, Nude; Saponins; Triterpenes	2021
Platycodin D inhibits the malignant progression of papillary thyroid carcinoma by NF-κB and enhances the therapeutic efficacy of pembrolizumab. Drug development research, 2022, Volume: 83, Issue:3 Topics: Antibodies, Monoclonal, Humanized; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; NF-kappa B; Saponins; Thyroid Cancer, Papillary; Thyroid Neoplasms; Triterpenes	2022
Caspase-1-Dependent Pyroptosis Mediates Adjuvant Activity of Platycodin D as an Adjuvant for Intramuscular Vaccines. Cells, 2022, 01-01, Volume: 11, Issue:1 Topics: Animals; Caspase 1; Female; Humans; Injections, Intramuscular; Mice; Pyroptosis; Saponins; Signal Transduction; Triterpenes; Vaccines	2022
Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4). Bioengineered, 2022, Volume: 13, Issue:3 Topics: Cell Line; Ferroptosis; Glucose; Humans; Phospholipid Hydroperoxide Glutathione Peroxidase; Saponins; Triterpenes	2022
Platycodin D Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis by Blocking the Activation of Mitogen-Activated Protein Kinases and the Production of Interleukin-8. The American journal of Chinese medicine, 2022, Volume: 50, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Cell Movement; Extracellular Signal-Regulated MAP Kinases; Human Umbilical Vein Endothelial Cells; Humans; Interleukin-8; Mice; Neovascularization, Pathologic; Saponins; Triterpenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2022
In addition to its endosomal escape effect, platycodin D also synergizes with ribosomal inactivation protein to induce apoptosis in hepatoma cells through AKT and MAPK signaling pathways. Chemico-biological interactions, 2022, Sep-01, Volume: 364 Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Endosomes; Humans; Liver Neoplasms; MAP Kinase Signaling System; Proto-Oncogene Proteins c-akt; Ribosomal Proteins; Saponins; Signal Transduction; Triterpenes	2022
Induction of apoptosis through inactivation of ROS-dependent PI3K/Akt signaling pathway by platycodin D in human bladder urothelial carcinoma cells. General physiology and biophysics, 2022, Volume: 41, Issue:4 Topics: Apoptosis; Carcinoma, Transitional Cell; Humans; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Saponins; Signal Transduction; TOR Serine-Threonine Kinases; Triterpenes; Urinary Bladder; Urinary Bladder Neoplasms	2022
Whole Transcriptome Analysis Identifies Platycodin D-Mediated RNA Regulatory Network in Non-Small-Cell Lung Cancer. Cells, 2022, 08-01, Volume: 11, Issue:15 Topics: Carcinoma, Non-Small-Cell Lung; Gene Expression Profiling; Humans; Lung Neoplasms; Molecular Docking Simulation; RNA; RNA, Messenger; RNA, Untranslated; Saponins; Transcriptome; Triterpenes	2022
Seasonal variation in the total saponin content of platycodon roots cultivated in Japan. Journal of natural medicines, 2023, Volume: 77, Issue:1 Topics: Japan; Plant Roots; Platycodon; Saponins; Seasons; Triterpenes	2023
Platycodin D stimulates AMPK activity to inhibit the neurodegeneration caused by reactive oxygen species-induced inflammation and apoptosis. Journal of ethnopharmacology, 2023, May-23, Volume: 308 Topics: Alzheimer Disease; AMP-Activated Protein Kinases; Animals; Antioxidants; Apoptosis; Inflammation; Mice; Molecular Docking Simulation; Neurodegenerative Diseases; Oxidative Stress; Reactive Oxygen Species; Saponins	2023
Platycodin D induces proliferation inhibition and mitochondrial apoptosis in diffuse large B-cell lymphoma. Experimental hematology, 2023, Volume: 123 Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Lymphoma, Large B-Cell, Diffuse; Mice; Mitochondria; Neoplasm Recurrence, Local; Proto-Oncogene Proteins c-bcl-2; Saponins; Triterpenes	2023
Platycodin D relieves rheumatoid arthritis by promoting apoptosis of mitochondria to inhibit activation of hedgehog pathway. Autoimmunity, 2023, Volume: 56, Issue:1 Topics: Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Hedgehog Proteins; Inflammation; Interleukin-6; Rats; Saponins; Synovial Membrane; Triterpenes; Tumor Necrosis Factor-alpha	2023
Platycodin D represses β-catenin to suppress metastasis of cetuximab-treated KRAS wild-type colorectal cancer cells. Clinical & experimental metastasis, 2023, Volume: 40, Issue:4 Topics: Animals; beta Catenin; Caco-2 Cells; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cetuximab; Colorectal Neoplasms; Humans; Mice; Mice, Nude; Proto-Oncogene Proteins p21(ras); Saponins; Triterpenes; Wnt Signaling Pathway	2023
Platycodin D induces apoptotic cell death through PI3K/AKT and MAPK/ERK pathways and synergizes with venetoclax in acute myeloid leukemia. European journal of pharmacology, 2023, Oct-05, Volume: 956 Topics: Apoptosis; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Humans; Leukemia, Myeloid, Acute; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Saponins; Triterpenes	2023
Platycodin D induces neutrophil apoptosis by downregulating PD-L1 expression to inhibit breast cancer pulmonary metastasis. International immunopharmacology, 2023, Volume: 115 Topics: Animals; Apoptosis; B7-H1 Antigen; Lung Neoplasms; Mice; Neutrophils; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Saponins; Triterpenes	2023
Investigation of the response of Platycodongrandiflorus (Jacq.) A. DC to salt stress using combined transcriptomics and metabolomics. BMC plant biology, 2023, Nov-25, Volume: 23, Issue:1 Topics: Lignin; Salt Tolerance; Saponins; Transcriptome; Triterpenes	2023