platinum has been researched along with guanine in 94 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (6.38) | 18.7374 |
1990's | 8 (8.51) | 18.2507 |
2000's | 35 (37.23) | 29.6817 |
2010's | 34 (36.17) | 24.3611 |
2020's | 11 (11.70) | 2.80 |
Authors | Studies |
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Elding, LI; Reedijk, J; Struik, AF; van Boom, JH; Zuiderwijk, CT | 1 |
Dempke, WC; Fichtinger-Schepman, AM; Hill, BT; Shellard, SA | 1 |
Fichtinger-Schepman, AM; Lohman, PH; Plooy, AC; Schutte, HH; van Dijk, M | 1 |
Crumpacker, CS; Henry, PH; Kakefuda, T; Levin, MJ; Lewis, AM; Rowe, WP | 1 |
Kelman, AD; Sinex, FM; Stone, PJ | 1 |
Robins, AB | 1 |
Eagles, J; Roos, IA; Thomson, AJ | 1 |
den Hartog, JH; Marcelis, AT; Reedijk, J; van der Marel, GA; Wille, G | 1 |
Doi, M; Ishida, T; Kawai, H; Tarui, M | 1 |
Hampson, R; Karran, P | 1 |
Berners-Price, SJ; Chottard, JC; Corazza, A; Guo, Z; Hambley, TW; Murdoch, PD; Reeder, F; Sadler, PJ | 1 |
Boffetta, P; Fichtinger-Schepman, AM; Fosså, SD; Kaldor, J; Keizer, HJ; Roy, P; Stoter, G; van Dijk-Knijnenburg, HC; van Oosterom, AT; Weiderpass, E | 1 |
Freisinger, E; Hegmans, A; Janik, MB; Lippert, B | 1 |
Kutin, AA; Stefanov, VE; Tulub, AA | 1 |
Burda, JV; Leszczynski, J; Sponer, J | 1 |
Reedijk, J; Teuben, JM | 1 |
Brabec, V; Farrell, N; Hofr, C | 1 |
Asano, K; Hamashima, H; Kobayashi, S; Maehara, T; Nakamura, Y; Ohishi, Y; Sasatsu, M; Tanaka, A | 1 |
Elizondo-Riojas, MA; Kozelka, J | 1 |
Chottard, JC; Kozelka, J; Monjardet-Bas, V | 1 |
Chikuma, M; Komeda, S; Lutz, M; Reedijk, J; Sato, T; Spek, AL; Yamanaka, Y | 1 |
Lippert, B; Lüth, MS; Sigel, H; Song, B | 1 |
Bombard, S; Chottard, JC; Elizondo-Riojas, MA; Redon, S | 1 |
Bombard, S; Chottard, JC; Kozelka, J; Monjardet-Bas, V | 1 |
Mitchell, J; Rowan, C; Williams, KM | 1 |
Gu, J; Leszczynski, J; Wang, J | 1 |
Garcìa, F; Haasnoot, JG; Kooijman, H; Reedijk, J; Spek, AL; van der Schilden, K | 1 |
Ali, MS; Guzman, IY; Khan, SR; Khokhar, AR; Ojima, H; Siddik, ZH; Whitmire, KH | 1 |
Delaney, SM; Dolan, ME; Egorin, MJ; Fishel, ML; Gamcsik, MP; Karrison, T; Maher, VM; Moschel, RC; Zuhowski, EG | 1 |
Beljanski, V; Doetsch, PW; Marzilli, LG; Natile, G; Villanueva, JM | 1 |
Deubel, DV | 1 |
Carloni, P; Magistrato, A; Reedijk, J; Ruggerone, P; Spiegel, K | 1 |
Amantia, D; Costisella, B; Houlton, A; Lippert, B; Morell Cerdà, M | 1 |
Burda, JV; Pavelka, M | 1 |
Chikuma, M; Farrell, NP; Komeda, S; Moulaei, T; Williams, LD; Woods, KK | 1 |
Bertrand, H; Bombard, S; Monchaud, D; Teulade-Fichou, MP | 1 |
Bombard, S; Chválová, K; Kozelka, J; Sari, MA | 1 |
Antonucci, D; Benedetti, M; Ciccarella, G; Ciccarese, A; Ducani, C; Fanizzi, FP; Migoni, D; Romano, A; Vecchio, VM; Verri, T | 1 |
Brabec, V; Heringová, P; Kaspárková, J; Mackay, FS; Moggach, SA; Parsons, S; Pizarro, AM; Sadler, PJ; Woods, JA | 1 |
Belani, C; Ramalingam, S | 1 |
Cini, R; Hursthouse, MB; Intini, FP; Natile, G; Tamasi, G | 1 |
Dolan, ME; Egorin, MJ; Fishel, ML; Holleran, JL; Kasza, K; Kelley, MR; Rabik, CA | 1 |
Maheshwari, V; Marzilli, LG; Marzilli, PA | 1 |
Anzellotti, AI; Bayse, CA; Farrell, NP | 1 |
Elmroth, SK; Kubota, LT; Mello, LD; Pereira, RM; Ribeiro, ES | 1 |
Ciuleanu, T; Darstein, CL; Latz, JE; Musib, LC; Specenier, PM; Vermorken, JB | 1 |
Dickgreber, NJ; Fink, TH; Hossain, AM; Latz, JE; Musib, LC; Thomas, M | 1 |
Barends, S; den Dulk, H; Hartl, F; Lutz, M; Maheswari, PU; Reedijk, J; Roy, S; Spek, AL; van Wezel, GP | 1 |
Chen, ZW; Lu, S; Zhang, YF | 1 |
Compton, RG; Hardacre, C; Rogers, EI; Zanoni, MV | 1 |
Berard, H; Bota, S; Chouaid, C; Corre, R; Crequit, J; Dujon, C; Paillotin, D; Robinet, G; Thomas, P; Vergnenegre, A | 1 |
Jiang, J; Li, L; Lin, Q; Tian, J; Wang, Q; Wang, X | 1 |
Fan, Y; Huang, ZY; Luo, LH; Yu, HF | 1 |
Bergot, E; Lechapt, E; Zalcman, G | 1 |
Bogart, JA; Choi, S; Laryea-Walker, E; Personick, ML; Redman, RM; Ryu, D | 1 |
Benedetti, M; Marzilli, LG; Natile, G; Saad, JS | 1 |
Bennouna, J; de Castro, J; Dingemans, AM; Gridelli, C; Griesinger, F; Grossi, F; Langer, C; Rossi, A; Thatcher, N; Wong, EK | 1 |
Albertí, FM; Lippert, B; Müller, B; Noguera, M; Rodríguez-Santiago, L; Sanz Miguel, PJ; Shen, WZ; Sodupe, M; van der Wijst, T | 1 |
Saijo, N | 1 |
An, TT; Bai, H; Duan, JC; Liu, XH; Wang, J; Wang, SH; Wang, YY; Wang, ZJ; Wu, MN; Yang, L; Zhao, J; Zhuo, ML | 1 |
Chikuma, M; Komeda, S; Nishio, K; Suzuki, T; Uemura, M | 1 |
He, J; Li, H; Lu, J; Ma, P; Qin, Y; Wang, J; Wei, L; Xu, J; Zhang, X | 1 |
Amundsen, T; Anderssen, E; Dobra, K; Erlandsen, SE; Flatberg, A; Røe, OD; Sandeck, H; Sundstrøm, SH; Szulkin, A | 1 |
Graham, MK; Miller, PS | 1 |
Hashemi-Sadraei, N; Pennell, NA | 1 |
Carneiro, JW; Farrell, NP; Kipping, R; Neves, AP; Pereira, MX; Peterson, EJ; Silva, FP; Vargas, MD | 1 |
Abacı, S; Erdem, A; Kuralay, F; Ozyörük, H | 1 |
Barrington, S; Cane, P; Dunn, JT; Lal, R; Landau, D; Lang-Lazdunski, L; McLennan, B; Papa, S; Popat, S; Prevost, AT; Shah, R; Spicer, J; Viney, Z | 1 |
Akca, Z; Aksahin, A; Aslan, T; Berk, V; Buyukcelik, A; Erden, A; Karaca, H; Mutlu, H; Ozkan, M | 1 |
Eaddy, M; Green, MR; Gruschkus, SK; Peterson, P; Shah, M; Winfree, KB | 1 |
Cao, J; Huang, XE; Liu, J; Lu, YY; Wu, XY; Xiang, J; Xu, L; Xu, X | 1 |
Hao, X; He, P; Hu, X; Li, J; Shi, Y; Wang, B; Wang, H; Wang, Y; Wang, Z; Yang, S; Yu, S; Zhang, X | 1 |
Butler, JS; Farrer, NJ; Habtemariam, A; Li, H; McQuitty, RJ; Sadler, PJ; Wang, F; Zhao, Y | 1 |
Jangir, DK; Mehrotra, R | 1 |
Dyszkiewicz, W; Kalinka-Warzocha, E; Kałakucka, K; Knetki-Wróblewska, M; Kowalski, DM; Krawczyk, P; Krzakowski, M; Kucharczyk, T; Milanowski, J; Powrózek, T; Ramlau, R; Winiarczyk, K; Wojas-Krawczyk, K | 1 |
Anik, Ü; Sultan, SC | 1 |
Georgoulias, V; Giagkas, G; Ioannidis, G; Koutsopoulos, A; Lagoudaki, E; Mavroudis, D; Papadaki, C; Sfakianaki, M; Souglakos, J; Trypaki, M; Tsakalaki, E; Voutsina, A | 1 |
Dyszkiewicz, W; Kalinka-Warzocha, E; Knetki-Wróblewska, M; Kowalski, DM; Krawczyk, P; Krzakowski, M; Kucharczyk, T; Milanowski, J; Powrózek, T; Ramlau, R; Winiarczyk, K | 1 |
Chen, Q; Ding, L; Gao, H; Hong, X; Jiang, Z; Liang, Y; Liu, K; Wu, H; Zhou, N | 1 |
Hong, YS; Hwang, G; Lee, J; Sim, T | 1 |
Emin, S; Filipov, C; Loukanov, A; Mladenova, P; Toshev, S | 1 |
Marzo, T; Massai, L; Messori, L; Michelucci, E; Montesarchio, D; Mügge, C; Musumeci, D; Porru, F; Weigand, W | 1 |
Cai, S; Chen, R; Jung, C; Lu, J; Sun, L; Ye, J; Zeng, S; Zhou, Y | 1 |
Guo, Z; Li, T; Qian, C; Wang, X | 1 |
Borah, ST; Das, B; Ganguli, S; Gupta, P | 1 |
Chen, M; Jia, Z; Liang, Y; Mergny, JL; Miron, CE; Petitjean, A; Rangaswamy, AM; van Staalduinen, L | 1 |
Garoufis, A; Kordias, D; Kougioumtzi, A; Magklara, A; Nikolaou, N; Tsolis, T; Ypsilantis, K | 1 |
Chen, A; Govindhan, M; Liu, Z; Mao, B; Qian, L | 1 |
Bajor, DL; Biswas, T; Bruno, DS; Cao, S; Dowlati, A; Fu, P; Gerson, SL; Kunos, CA; Machtay, M; Malik, S; Oleinick, NL; Patel, M; Pink, JJ | 1 |
Chen, M; Mergny, JL; Miron, CE; Petitjean, A | 1 |
Czeleń, P; Jezierska, A; Szefler, B; Wojtkowiak, K | 1 |
Barretta, P; Mazzone, G; Ponte, F; Scoditti, S; Sicilia, E; Vigna, V | 1 |
Abo Elkasem, F; Bahnassy, A; Gaafer, R; Khorshid, O; Wahba, NI | 1 |
Chiavarino, B; Corinti, D; Crestoni, ME; Fornarini, S; Rotari, L; Salpin, JY; Scuderi, D | 1 |
5 review(s) available for platinum and guanine
Article | Year |
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Genomic instability and tolerance to alkylating agents.
Topics: Antineoplastic Agents, Alkylating; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Adducts; DNA Damage; DNA Methylation; DNA Repair; Guanine; Humans; Methyltransferases; Microsatellite Repeats; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Platinum | 1996 |
Systemic chemotherapy for advanced non-small cell lung cancer: recent advances and future directions.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Erlotinib Hydrochloride; Gemcitabine; Glutamates; Guanine; Humans; Lung Neoplasms; Neoplasm Staging; Pemetrexed; Platinum; Protein Kinase Inhibitors; Quality of Life; Quinazolines; Survival Rate; Taxoids; Treatment Outcome | 2008 |
[A meta-analysis of pemetrexed plus platinum chemotherapy versus gemcitabine plus platinum chemotherapy for advanced non-small cell lung cancer].
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Drug Therapy, Combination; Gemcitabine; Glutamates; Guanine; Humans; Lung Neoplasms; Pemetrexed; Platinum; Randomized Controlled Trials as Topic; Survival Rate; Treatment Outcome | 2011 |
Problems involved in the clinical trials for non-small cell lung carcinoma.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Glutamates; Guanine; Humans; Lung Neoplasms; Maintenance Chemotherapy; Mutation; Patient Selection; Pemetrexed; Platinum; Quinazolines | 2012 |
Pemetrexed plus platinum or gemcitabine plus platinum for advanced non-small cell lung cancer: final survival analysis from a multicentre randomized phase II trial in the East Asia region and a meta-analysis.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asia; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Female; Gemcitabine; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Platinum; Survival Analysis; Treatment Outcome | 2013 |
9 trial(s) available for platinum and guanine
Article | Year |
---|---|
Pharmacokinetic evaluation of platinum derived from cisplatin administered alone and with pemetrexed in head and neck cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carcinoma, Squamous Cell; Cisplatin; Cross-Over Studies; Dietary Supplements; Female; Glutamates; Guanine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Staging; Pemetrexed; Platinum; Prognosis; Treatment Outcome | 2009 |
Phase I and pharmacokinetic study of pemetrexed plus cisplatin in chemonaive patients with locally advanced or metastatic malignant pleural mesothelioma or non-small cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Dietary Supplements; Drug Administration Schedule; Female; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Mesothelioma; Middle Aged; Pemetrexed; Platinum; Pleural Neoplasms; Vitamins | 2009 |
Cost-effectiveness of second-line chemotherapy for non-small cell lung cancer: an economic, randomized, prospective, multicenter phase III trial comparing docetaxel and pemetrexed: the GFPC 05-06 study.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Docetaxel; Female; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pemetrexed; Platinum; Prospective Studies; Salvage Therapy; Survival Rate; Taxoids; Treatment Outcome | 2011 |
[Efficacy of salvage chemotherapy in the advanced non-small cell lung cancer patients who failed the treatment of chemotherapy and EGFR-TKI].
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Docetaxel; ErbB Receptors; Erlotinib Hydrochloride; Female; Follow-Up Studies; Gefitinib; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Neutropenia; Pemetrexed; Platinum; Protein Kinase Inhibitors; Quinazolines; Remission Induction; Salvage Therapy; Taxoids; Treatment Failure | 2010 |
Randomized phase IIIb trial evaluating the continuation of bevacizumab beyond disease progression in patients with advanced non-squamous non-small-cell lung cancer after first-line treatment with bevacizumab plus platinum-based chemotherapy: treatment rat
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Docetaxel; Erlotinib Hydrochloride; Female; Follow-Up Studies; Glutamates; Guanine; Humans; International Agencies; Lung Neoplasms; Maintenance Chemotherapy; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Pemetrexed; Platinum; Quality of Life; Quinazolines; Survival Rate; Taxoids; Treatment Outcome; Young Adult | 2011 |
Pemetrexed plus platinum or gemcitabine plus platinum for advanced non-small cell lung cancer: final survival analysis from a multicentre randomized phase II trial in the East Asia region and a meta-analysis.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asia; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Female; Gemcitabine; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Platinum; Survival Analysis; Treatment Outcome | 2013 |
Phase 2 study of sorafenib in malignant mesothelioma previously treated with platinum-containing chemotherapy.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Glutamates; Guanine; Humans; Male; Mesothelioma; Middle Aged; Neoplasm Staging; Niacinamide; Pemetrexed; Phenylurea Compounds; Platinum; Pleural Neoplasms; Prognosis; Protein Kinase Inhibitors; Salvage Therapy; Sorafenib; Survival Rate | 2013 |
Phase II study on Javanica oil emulsion injection (Yadanzi®) combined with chemotherapy in treating patients with advanced lung adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brucea; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Emulsions; Female; Follow-Up Studies; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pemetrexed; Phytotherapy; Plant Oils; Platinum; Prognosis | 2013 |
Adding Base-Excision Repair Inhibitor TRC102 to Standard Pemetrexed-Platinum-Radiation in Patients with Advanced Nonsquamous Non-Small Cell Lung Cancer: Results of a Phase I Trial.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; DNA Repair; Glutamates; Guanine; Humans; Lung Neoplasms; Pemetrexed; Platinum | 2022 |
81 other study(ies) available for platinum and guanine
Article | Year |
---|---|
Guanine-06 methylation reduces the reactivity of d(GpG) towards platinum complexes.
Topics: Binding, Competitive; Cisplatin; Deoxyguanine Nucleotides; DNA; Guanine; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Methylation; Nucleic Acid Conformation; Platinum; Structure-Activity Relationship | 1991 |
Lack of significant modulation of the formation and removal of platinum-DNA adducts by aphidicolin glycinate in two logarithmically-growing ovarian tumour cell lines in vitro.
Topics: Antibiotics, Antineoplastic; Aphidicolin; Cisplatin; Diterpenes; DNA; DNA Damage; DNA Polymerase II; DNA Repair; Female; Guanine; Humans; Ovarian Neoplasms; Platinum; Tumor Cells, Cultured | 1991 |
The quantitative detection of various Pt-DNA-adducts in Chinese hamster ovary cells treated with cisplatin: application of immunochemical techniques.
Topics: Animals; Cells, Cultured; Chromatography; Chromatography, High Pressure Liquid; Cisplatin; Cricetinae; Cricetulus; Deoxyguanine Nucleotides; DNA; Enzyme-Linked Immunosorbent Assay; Female; Guanine; Organoplatinum Compounds; Ovary; Platinum; Spectrophotometry, Atomic | 1985 |
Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. 3. Base composition, molecular weight, and conformation of the Ad2+ND genome.
Topics: Adenoviridae; Carbon; Centrifugation, Density Gradient; Centrifugation, Zonal; Cesium; Chlorides; Chymotrypsin; Cytosine; DNA, Viral; Genes; Guanine; Hot Temperature; Hybridization, Genetic; Microscopy, Electron; Molecular Biology; Molecular Weight; Nucleic Acid Denaturation; Platinum; Simian virus 40 | 1971 |
Specific binding of antitumour drug cis-Pt(NH3)2C12 to DNA rich in guanine and cytosine.
Topics: Animals; Antineoplastic Agents; Binding Sites; Centrifugation, Density Gradient; Cisplatin; Cytosine; DNA; DNA, Bacterial; Guanine; Liver; Platinum; Rats; Scintillation Counting; Spectrum Analysis; Thymidine; Thymus Gland; Tritium | 1974 |
The reaction of 14 C-labelled platinum ethylenediamine dichloride with nucleic acid constituents.
Topics: Antineoplastic Agents; Carbon Isotopes; Chemical Phenomena; Chemistry; Chlorides; Chromatography, Paper; Cytosine; Ethylenediamines; Guanine; Kinetics; Nucleic Acids; Organoplatinum Compounds; Platinum; Radioisotopes; Spectrophotometry, Ultraviolet; Thymine; Tritium; Ultraviolet Rays | 1973 |
Mass spectrometric studies of the interaction of platinum complexes with nucleoside analogues.
Topics: Adenine; Binding Sites; Cytosine; Guanine; Ligands; Mass Spectrometry; Methylation; Molecular Conformation; Nucleic Acid Conformation; Platinum; Structure-Activity Relationship; Thymine; Time Factors | 1974 |
Interaction of platinum compounds with short oligodeoxynucleotides containing guanine and cytosine.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Circular Dichroism; Cytosine; Guanine; Magnetic Resonance Spectroscopy; Oligodeoxyribonucleotides; Oligonucleotides; Platinum; Temperature | 1983 |
Enhancement of aromatic amino acid-nucleic acid base stacking interaction by metal coordination to base: fluorescence study on a tryptophan-Pt(II)-guanine ternary complex.
Topics: Base Composition; Fluorescence; Guanine; Platinum; Platinum Compounds; Purines; Tryptophan | 1995 |
Platination of a GG site on single-stranded and double-stranded forms of a 14-base oligonucleotide with diaqua cisplatin followed by NMR and HPLC -- influence of the platinum ligands and base sequence on 5'-G versus 3'-G platination selectivity.
Topics: Base Sequence; Chromatography, High Pressure Liquid; Cisplatin; Guanine; Indicators and Reagents; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Platinum; Platinum Compounds | 1997 |
Cisplatin-DNA adducts and protein-bound platinum in blood of testicular cancer patients.
Topics: Adult; Antineoplastic Agents; Cisplatin; DNA Adducts; Guanine; Humans; Male; Platinum; Protein Binding; Testicular Neoplasms; Treatment Outcome | 1998 |
Reactivity of an extremely sterically crowded monofunctional Pt complex, [Pt(1-MeC-N3)3(H2O)]2+ (1-MeC = 1-methylcytosine), toward model nucleobases and selectivity toward guanine in single- and double-stranded deoxyoligonucleotides.
Topics: Deoxyribonucleotides; DNA; DNA, Single-Stranded; Guanine; In Situ Hybridization; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleotides; Organoplatinum Compounds; Platinum; Solutions; Substrate Specificity | 1999 |
The effect of the chain length of polynucleotides on their binding with platinum complexes.
Topics: Adenine; Cisplatin; Cytosine; DNA; DNA Adducts; Guanine; Isotopes; Kinetics; Magnetic Resonance Spectroscopy; Platinum; Polynucleotides; Structure-Activity Relationship | 1999 |
The interactions of square platinum(II) complexes with guanine and adenine: a quantum-chemical ab initio study of metalated tautomeric forms.
Topics: Adenine; Chemical Phenomena; Chemistry, Physical; Cisplatin; Electrochemistry; Guanine; Ligands; Molecular Conformation; Platinum; Protons | 2000 |
Reaction of DNA oligonucleotides with [Pt(dien)GSMe]2+ (GSMe = S-methylated glutathione) and cis-[Pt(NH3)2(GSMe)2]2+: evidence of oligonucleotide platination via sulfur-coordinated platinum intermediates.
Topics: Chromatography; Cisplatin; DNA Adducts; Glutathione; Guanine; Humans; Kinetics; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oligodeoxyribonucleotides; Organoplatinum Compounds; Platinum; Sulfides; Sulfur | 2000 |
Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex.
Topics: Antineoplastic Agents; Base Sequence; Binding Sites; Calorimetry, Differential Scanning; Circular Dichroism; Cisplatin; Cross-Linking Reagents; DNA Adducts; DNA-Binding Proteins; Entropy; Guanine; High Mobility Group Proteins; Mutagenesis, Site-Directed; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Platinum; Protein Structure, Tertiary; Spectrophotometry, Ultraviolet; Temperature; Thermodynamics | 2001 |
DNA topology on an increase in positive writhing number of DNA: conformation changes in the time course of cis-diamminedichloroplatinum(II)-DNA adducts.
Topics: Algorithms; Antineoplastic Agents; Cisplatin; Cyanides; DNA; DNA Adducts; DNA, Superhelical; Electrophoresis, Polyacrylamide Gel; Guanine; Microscopy, Electron; Nucleic Acid Conformation; Platinum; Stereoisomerism | 2001 |
Unrestrained 5 ns molecular dynamics simulation of a cisplatin-DNA 1,2-GG adduct provides a rationale for the NMR features and reveals increased conformational flexibility at the platinum binding site.
Topics: Base Sequence; Cisplatin; Computer Simulation; Deoxyribose; DNA Adducts; Guanine; Hydrogen Bonding; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Organoplatinum Compounds; Phosphates; Platinum; Pliability; Software; Water | 2001 |
Fast interstrand cross-linking of cisplatin-DNA monoadducts compared with intrastrand chelation: a kinetic study using hairpin-stabilized duplex oligonucleotides.
Topics: Antineoplastic Agents; Chelating Agents; Chromatography, High Pressure Liquid; Circular Dichroism; Cisplatin; Cross-Linking Reagents; DNA Adducts; Guanine; Kinetics; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Oligonucleotides; Platinum | 2002 |
A novel isomerization on interaction of antitumor-active azole-bridged dinuclear platinum(II) complexes with 9-ethylguanine. Platinum(II) atom migration from N2 to N3 on 1,2,3-triazole.
Topics: Animals; Antineoplastic Agents; Cisplatin; Crystallography, X-Ray; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Guanine; Hydrogen-Ion Concentration; Isomerism; Leukemia L1210; Mice; Nuclear Magnetic Resonance, Biomolecular; Organoplatinum Compounds; Platinum; Triazoles; Tumor Cells, Cultured | 2002 |
Isomeric equilibria in aqueous solution involving aromatic ring stacking in the sexternary complexes formed by the quaternary cis-(NH3)2Pt(2'-deoxyguanosine-N7)(dGMP-N7) complex and the binary Cu(2,2'-bipyridine)2+ or Cu(1,10-phenanthroline)2+ complexes (
Topics: Algorithms; Amines; Copper; Guanine; Guanosine Monophosphate; Organometallic Compounds; Phenanthrolines; Platinum; Stereoisomerism | 2000 |
Platinum cross-linking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutions.
Topics: Adenine; Base Sequence; Binding Sites; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Guanine; Humans; Nucleic Acid Conformation; Oligonucleotides; Platinum; Potassium; Repetitive Sequences, Nucleic Acid; Sodium; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Telomere | 2003 |
GA and AG sequences of DNA react with cisplatin at comparable rates.
Topics: Adenine; Animals; Antineoplastic Agents; Base Sequence; Chelating Agents; Cisplatin; Cross-Linking Reagents; Crotalid Venoms; DNA; DNA Adducts; Exonucleases; Guanine; Kinetics; Nucleic Acid Conformation; Oligonucleotides; Platinum; Sequence Analysis, DNA; Water | 2003 |
Effect of amine ligand bulk on the interaction of methionine with platinum(II) diamine complexes.
Topics: Antineoplastic Agents; Cisplatin; Crystallography, X-Ray; Diamines; Guanine; Guanosine Monophosphate; Indicators and Reagents; Ligands; Magnetic Resonance Spectroscopy; Methionine; Models, Molecular; Platinum | 2004 |
H-bonding patterns in the platinated guanine-cytosine base pair and guanine-cytosine-guanine-cytosine base tetrad: an electron density deformation analysis and AIM study.
Topics: Base Pairing; Crystallography, X-Ray; Cytosine; Dimerization; Guanine; Hydrogen Bonding; Models, Molecular; Nucleic Acid Conformation; Organoplatinum Compounds; Platinum; Thermodynamics | 2004 |
A highly flexible dinuclear ruthenium(II)-platinum(II) complex: crystal structure and binding to 9-ethylguanine.
Topics: Antineoplastic Agents; Binding Sites; Cations, Divalent; Crystallography, X-Ray; DNA; Guanine; Intercalating Agents; Organometallic Compounds; Platinum; Ruthenium | 2004 |
Model platinum nucleobase and nucleoside complexes and antitumor activity: X-ray crystal structure of [PtIV(trans-1R,2R-diaminocyclohexane)trans-(acetate)2(9-ethylguanine)Cl]NO3.H2O.
Topics: Antineoplastic Agents; Cisplatin; Crystallography, X-Ray; Cyclohexylamines; Guanine; Humans; Inhibitory Concentration 50; Models, Molecular; Nitrates; Nucleosides; Organoplatinum Compounds; Platinum; Structure-Activity Relationship; Tumor Cells, Cultured | 2005 |
Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Cisplatin; DNA Damage; DNA Repair; Drug Synergism; Glutathione; Guanine; Humans; Platinum; Tumor Cells, Cultured | 2005 |
Marked dependence on carrier-ligand bulk but not on carrier-ligand chirality of the duplex versus single-strand forms of a DNA oligonucleotide with a series of G-Pt(II)-G intrastrand cross-links modeling cisplatin-DNA adducts.
Topics: Antineoplastic Agents; Cisplatin; DNA Adducts; DNA, Single-Stranded; Electrophoresis; Guanine; Ligands; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Platinum; Stereoisomerism | 2005 |
The chemistry of dinuclear analogues of the anticancer drug cisplatin. A DFT/CDM study.
Topics: Antineoplastic Agents; Cisplatin; Guanine; Hydrogen Bonding; Hydrolysis; Models, Molecular; Platinum; Sulfides; Thermodynamics | 2006 |
Binding of novel azole-bridged dinuclear platinum(II) anticancer drugs to DNA: insights from hybrid QM/MM molecular dynamics simulations.
Topics: Algorithms; Allyl Compounds; Antineoplastic Agents; Binding Sites; Cations, Divalent; Computer Simulation; DNA; Guanine; Hydrogen Bonding; Isomerism; Ligands; Models, Molecular; Nitrogen; Platinum; Quantum Theory; Thermodynamics; Triazoles | 2006 |
Multiple metal binding to 6-oxopurine nucleobases as a source of deprotonation. The role of metal ions at N7 and N3.
Topics: Binding Sites; Crystallography, X-Ray; Guanine; Heterocyclic Compounds; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Organoplatinum Compounds; Palladium; Platinum; Protons; Purinones | 2006 |
Pt-bridges in various single-strand and double-helix DNA sequences. DFT and MP2 study of the cisplatin coordination with guanine, adenine, and cytosine.
Topics: Adenine; Cisplatin; Cytosine; DNA, Single-Stranded; Guanine; Models, Molecular; Nucleic Acid Heteroduplexes; Platinum | 2007 |
A third mode of DNA binding: Phosphate clamps by a polynuclear platinum complex.
Topics: Amines; DNA; Guanine; Hydrogen; Hydrogen Bonding; Ions; Models, Molecular; Molecular Structure; Organoplatinum Compounds; Oxygen; Phosphates; Platinum | 2006 |
A platinum-quinacridine hybrid as a G-quadruplex ligand.
Topics: Acridines; Electrophoresis, Agar Gel; G-Quadruplexes; Guanine; Ligands; Molecular Structure; Organoplatinum Compounds; Platinum | 2007 |
LEF-1 recognition of platinated GG sequences within double-stranded DNA. Influence of flanking bases.
Topics: Base Sequence; Cisplatin; DNA; DNA Adducts; DNA-Binding Proteins; Guanine; High Mobility Group Proteins; Lymphoid Enhancer-Binding Factor 1; Oligonucleotides; Platinum | 2008 |
Experimental evidence that a DNA polymerase can incorporate N7-platinated guanines to give platinated DNA.
Topics: DNA; DNA-Directed DNA Polymerase; Guanine; Molecular Structure; Plasmids; Platinum | 2008 |
A potent cytotoxic photoactivated platinum complex.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Cross-Linking Reagents; Crystallography, X-Ray; DNA; DNA Adducts; Electrophoresis; Genes, p53; Guanine; Humans; Light; Molecular Conformation; Nucleic Acid Conformation; Organoplatinum Compounds; Photochemistry; Platinum; Tumor Suppressor Protein p53 | 2007 |
NMR and X-ray structural characterization of a cisplatin analogue able to slow down the Pt-N7 rotation of a coordinated guanine base by a billion-fold times: 2,2'-bipiperidine(dimethylmalonato)platinum(II) complex.
Topics: Cisplatin; Crystallography, X-Ray; DNA; Guanine; Ligands; Magnetic Resonance Spectroscopy; Nitrogen; Organoplatinum Compounds; Platinum; Rotation; Stereoisomerism | 2008 |
Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress.
Topics: Antineoplastic Agents; Caspase 12; Caspase 3; Cell Line, Tumor; Cisplatin; DNA; DNA Breaks, Double-Stranded; Drug Synergism; Endoplasmic Reticulum; Guanine; Humans; Platinum; RNA, Messenger; Transcription Factor CHOP | 2008 |
Neglected bidentate sp2 N-donor carrier ligands with triazine nitrogen lone pairs: platinum complexes retromodeling cisplatin guanine nucleobase adducts.
Topics: Cisplatin; Guanine; Ligands; Molecular Conformation; Nitrogen; Platinum; Triazines | 2008 |
Effects of nucleobase metalation on frontier molecular orbitals: potential implications for pi-stacking interactions with tryptophan.
Topics: Cytosine; Guanine; Models, Chemical; Models, Molecular; Organometallic Compounds; Organoplatinum Compounds; Palladium; Platinum; Static Electricity; Thermodynamics; Tryptophan | 2008 |
Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex.
Topics: Antineoplastic Agents; Buffers; Cisplatin; DNA; Electrochemistry; Guanidine; Guanine; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Metals; Models, Chemical; Platinum; Protein Binding; Spectrophotometry | 2009 |
DNA cleavage and antitumour activity of platinum(II) and copper(II) compounds derived from 4-methyl-2-N-(2-pyridylmethyl)aminophenol: spectroscopic, electrochemical and biological investigation.
Topics: Aminophenols; Animals; Antineoplastic Agents; Cattle; Cell Line, Tumor; Circular Dichroism; Coordination Complexes; Copper; Crystallography, X-Ray; DNA; DNA Cleavage; Drug Screening Assays, Antitumor; Electrochemical Techniques; Guanine; Guanosine Monophosphate; Humans; Mice; Molecular Conformation; Platinum; Spectrophotometry, Ultraviolet | 2009 |
Pemetrexed monotherapy versus pemetrexed plus platinum combination as second-line treatment for advanced non-small cell lung cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Female; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Platinum; Retrospective Studies; Treatment Outcome | 2009 |
The electrochemical reduction of the purines guanine and adenine at platinum electrodes in several room temperature ionic liquids.
Topics: Adenine; Dimerization; Electrochemical Techniques; Electrodes; Guanine; Ionic Liquids; Oxidation-Reduction; Platinum; Temperature | 2010 |
Pemetrexed re-challenge in pleural malignant mesothelioma: an option for a subset of patients initially treated with pemetrexed-platinum doublets in the first-line setting?
Topics: Antineoplastic Agents; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Platinum; Pleural Neoplasms | 2011 |
Oxidation of a guanine derivative coordinated to a Pt(IV) complex initiated by intermolecular nucleophilic attacks.
Topics: Coordination Complexes; Guanine; Kinetics; Mass Spectrometry; Oxidation-Reduction; Oxygen; Platinum; Spectrophotometry, Ultraviolet; Thermodynamics | 2011 |
NMR studies of models having the Pt(d(GpG)) 17-membered macrocyclic ring formed in DNA by platinum anticancer drugs: Pt complexes with bulky chiral diamine ligands.
Topics: Antineoplastic Agents; Circular Dichroism; Cisplatin; Dinucleoside Phosphates; DNA; DNA Adducts; Guanine; Macrocyclic Compounds; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Motion; Neoplasms; Platinum; Putrescine; Stereoisomerism | 2011 |
Pt(II) coordination to N1 of 9-methylguanine: why it facilitates binding of additional metal ions to the purine ring.
Topics: Crystallization; Guanine; Molecular Structure; Nitrogen; Organoplatinum Compounds; Platinum | 2011 |
[Effect of pemetrexed plus platinum for chemotherapy-naive advanced non-small cell lung cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Female; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Platinum; Retrospective Studies; Thymidylate Synthase; Treatment Outcome; Young Adult | 2012 |
An in vivo highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex largely circumvents in vitro cisplatin resistance: two linkage isomers yield the same product upon reaction with 9-ethylguanine but exhibit different cytotoxic profiles.
Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cisplatin; Dimerization; Drug Resistance, Neoplasm; Guanine; Half-Life; Humans; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Platinum; Tetrazoles | 2012 |
Molecular resistance fingerprint of pemetrexed and platinum in a long-term survivor of mesothelioma.
Topics: 5'-Nucleotidase; Adult; Antineoplastic Agents; Biopsy; Cell Adhesion; Cohort Studies; DNA Repair; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genome-Wide Association Study; Glutamates; Guanine; Humans; Immunohistochemistry; Mesothelioma; Oligonucleotide Array Sequence Analysis; Pemetrexed; Platinum; Tomography, X-Ray Computed; Treatment Outcome | 2012 |
Inhibition of transcription by platinated triplex-forming oligonucleotides.
Topics: Animals; Base Sequence; CHO Cells; Cricetinae; Cross-Linking Reagents; DNA; Drug Delivery Systems; Drug Stability; Guanine; Molecular Sequence Data; Molecular Structure; Oligonucleotides; Platinum; Temperature; Transcription, Genetic | 2012 |
Advanced non-small cell lung cancer (NSCLC): maintenance therapy for all?
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Erlotinib Hydrochloride; Glutamates; Guanine; Humans; Induction Chemotherapy; Lung Neoplasms; Neoplasm Staging; Pemetrexed; Platinum; Quinazolines | 2012 |
Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases and their platinum(II) complexes.
Topics: Antineoplastic Agents; Binding Sites; Biological Transport; Cell Line, Tumor; Cell Survival; Comet Assay; Coordination Complexes; DNA; DNA Cleavage; DNA Topoisomerases, Type I; Guanine; Guanosine Monophosphate; Humans; Magnetic Resonance Spectroscopy; Mannich Bases; Molecular Structure; Naphthoquinones; Platinum; Topoisomerase I Inhibitors | 2013 |
Electrochemical characterization of redox polymer modified electrode developed for monitoring of adenine.
Topics: Adenine; Electric Impedance; Electrochemistry; Electrodes; Ferrous Compounds; Guanine; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Oxidation-Reduction; Platinum; Polymers; Polyvinyls; Uric Acid | 2013 |
Secondline chemotherapy versus best supportive care in patient with malignant pleural mesothelioma: a retrospective study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Female; Follow-Up Studies; Gemcitabine; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Mesothelioma; Mesothelioma, Malignant; Middle Aged; Neoplasm Staging; Palliative Care; Pemetrexed; Platinum; Pleural Neoplasms; Prognosis; Retrospective Studies; Salvage Therapy; Survival Rate | 2013 |
Cost effectiveness of first-line pemetrexed plus platinum compared with other regimens in the treatment of patients with nonsquamous non-small cell lung cancer in the US outpatient setting.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cost-Benefit Analysis; Disease-Free Survival; Female; Glutamates; Guanine; Humans; Induction Chemotherapy; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Observational Studies as Topic; Pemetrexed; Platinum; Proportional Hazards Models; Retrospective Studies; Treatment Outcome; United States | 2013 |
[Efficacy of chemotherapy after EGFR-TKIs resistance in 191 patients with Unknow EGFR gene mutation in advanced lung adenocarcinoma].
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; ErbB Receptors; Female; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Pemetrexed; Platinum; Protein Kinase Inhibitors; Retrospective Studies; Survival Rate | 2013 |
De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex.
Topics: Antineoplastic Agents; Guanine; Ligands; Oxidation-Reduction; Platinum; Singlet Oxygen | 2013 |
Raman spectroscopic evaluation of DNA adducts of a platinum containing anticancer drug.
Topics: Adenine; Animals; Antineoplastic Agents; Carboplatin; Cattle; Cisplatin; Cross-Linking Reagents; DNA; DNA Adducts; Guanine; Humans; Neoplasms; Nucleic Acid Conformation; Platinum; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thymus Gland | 2014 |
Polymorphisms in TS, MTHFR and ERCC1 genes as predictive markers in first-line platinum and pemetrexed therapy in NSCLC patients.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; DNA-Binding Proteins; Endonucleases; Female; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pemetrexed; Platinum; Polymorphism, Single Nucleotide; Proportional Hazards Models; Retrospective Studies; Thymidylate Synthase | 2014 |
Gr-Pt hybrid NP modified GCPE as label and indicator free electrochemical genosensor platform.
Topics: Electrochemistry; Escherichia coli; Graphite; Guanine; Limit of Detection; Nanoparticles; Nanotechnology; Nucleic Acid Hybridization; Oligonucleotides; Oxygen; Platinum | 2014 |
PKM2 as a biomarker for chemosensitivity to front-line platinum-based chemotherapy in patients with metastatic non-small-cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carrier Proteins; Deoxycytidine; Docetaxel; Female; Follow-Up Studies; Gemcitabine; Glutamates; Guanine; Humans; Immunoenzyme Techniques; Lung Neoplasms; Lymphatic Metastasis; Male; Membrane Proteins; Middle Aged; Neoplasm Staging; Pemetrexed; Platinum; Prognosis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Taxoids; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2014 |
Correlation between TS, MTHFR, and ERCC1 gene polymorphisms and the efficacy of platinum in combination with pemetrexed first-line chemotherapy in mesothelioma patients.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; DNA-Binding Proteins; Drug Resistance, Neoplasm; Endonucleases; Female; Glutamates; Guanine; Humans; Male; Mesothelioma; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutagenesis, Insertional; Pemetrexed; Pharmacogenetics; Platinum; Pleural Neoplasms; Polymorphism, Genetic; Prognosis; Retrospective Studies; Survival Analysis; Tandem Repeat Sequences; Thymidylate Synthase; Treatment Outcome | 2014 |
The efficacy and safety of pemetrexed plus bevacizumab in previously treated patients with advanced non-squamous non-small cell lung cancer (ns-NSCLC).
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pemetrexed; Platinum; Vascular Endothelial Growth Factor A | 2015 |
One step synthesis of quantum dot-magnetic nanoparticle heterodimers for dual modal imaging applications.
Topics: Cadmium; Dimerization; Guanine; HeLa Cells; Humans; Magnets; Molecular Imaging; Nanoparticles; Platinum; Quantum Dots | 2015 |
Electron microscopic visualization of complementary labeled DNA with platinum-containing guanine derivative.
Topics: DNA, Complementary; Guanine; Microscopy, Electron; Nucleic Acid Conformation; Platinum; Staining and Labeling | 2016 |
Elucidating the reactivity of Pt(II) complexes with (O,S) bidentate ligands towards DNA model systems.
Topics: Antineoplastic Agents; Binding Sites; Coordination Complexes; G-Quadruplexes; Guanine; Ligands; Models, Chemical; Oligodeoxyribonucleotides; Organoplatinum Compounds; Platinum; Spectrometry, Mass, Electrospray Ionization | 2016 |
A chemiluminescence resonance energy transfer strategy and its application for detection of platinum ions and cisplatin.
Topics: Animals; Aptamers, Nucleotide; Cisplatin; Energy Transfer; Fluoresceins; Fluorescent Dyes; Glyoxal; Guanine; Limit of Detection; Luminescence; Luminescent Measurements; Magnetic Phenomena; Platinum; Rats, Sprague-Dawley; Streptavidin | 2019 |
Guanine-guided time-resolved luminescence recognition of DNA modification and i-motif formation by a terbium(III)-platinum(II) complex.
Topics: Biosensing Techniques; Coordination Complexes; DNA; Guanine; Nucleotide Motifs; Platinum; Terbium | 2020 |
Phosphorescent Trinuclear Pt-Ir-Pt Complexes: Insights into the Photophysical and Electrochemical Properties and Interaction with Guanine Nucleobase.
Topics: Electrochemical Techniques; Guanine; Iridium; Luminescence; Organometallic Compounds; Platinum | 2020 |
Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution- and Solid-State Investigations.
Topics: G-Quadruplexes; Guanine; Platinum | 2021 |
Synthesis, characterization, interactions with 9-MeG and cytotoxic activity of heterobimetallic Ru
Topics: Animals; Antineoplastic Agents; Cisplatin; Coordination Complexes; Cymenes; Guanine; HeLa Cells; Humans; Hydrolysis; Magnetic Resonance Spectroscopy; MCF-7 Cells; Mice; NIH 3T3 Cells; Platinum; Pyrimidines; Ruthenium; Spectrometry, Mass, Electrospray Ionization | 2021 |
Simultaneous electrochemical detection of guanine and adenine using reduced graphene oxide decorated with AuPt nanoclusters.
Topics: Adenine; Alloys; Animals; Ascorbic Acid; Biosensing Techniques; DNA; Dopamine; Electrochemical Techniques; Electrodes; Gold; Graphite; Guanine; Limit of Detection; Male; Metal Nanoparticles; Nanocomposites; Oxidation-Reduction; Platinum; Salmon; Spermatozoa; Uric Acid | 2021 |
Portrait of a Family of Highly Stabilizing and Selective Guanine Quadruplex Platinum(II)-Based Binders.
Topics: DNA; G-Quadruplexes; Guanine; Ligands; Platinum | 2022 |
Affinities to Oxaliplatin: Vitamins from B Group vs. Nucleobases.
Topics: Adenine; Cisplatin; Cyclohexylamines; Cytosine; DNA; Guanine; Oxaliplatin; Platinum; Quantum Theory; Solvents; Thiamine; Vitamin A; Vitamins; Water | 2022 |
Computational Analysis of the Behavior of BODIPY Decorated Monofunctional Platinum(II) Complexes in the Dark and under Light Irradiation.
Topics: Boron Compounds; Guanine; Ligands; Organoplatinum Compounds; Photosensitizing Agents; Platinum; Water | 2022 |
The Predictive Value of ERCC1, RRM1, and Thymidylate Synthase in Advanced Malignant Pleural Mesothelioma Patients Treated with Platinum-Based Chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Endonucleases; Gemcitabine; Glutamates; Guanine; Humans; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Pemetrexed; Platinum; Prospective Studies; Thymidylate Synthase; Treatment Outcome | 2023 |
Binding Motifs of Carboplatin and Oxaliplatin with Guanine: A Combined MS/MS, IRMPD, and Theoretical Study.
Topics: Carboplatin; Guanine; Oxaliplatin; Platinum; Spectrophotometry, Infrared; Tandem Mass Spectrometry | 2023 |