platinum has been researched along with acridines in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.25) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 9 (28.13) | 29.6817 |
| 2010's | 14 (43.75) | 24.3611 |
| 2020's | 6 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Roos, IA | 1 |
| Cullinane, C; Denny, WA; McFadyen, WD; Palmer, BD; Phillips, DR; Wickham, G | 1 |
| Qi, H; Zhang, C | 1 |
| Adjei, AA; Alberts, SR; Ames, MM; Atherton, P; Boemer, SA; Erlichman, C; Goldberg, RM; Hanson, LJ; Kaufmann, SH; Pitot, HC; Reid, JM; Ruben, S; Sloan, JA | 1 |
| Baruah, H; Bierbach, U | 1 |
| HAYASHI, E; NAGAO, T | 1 |
| Anderson, JG; Bierbach, U; Hess, SM | 1 |
| Bertrand, H; Bombard, S; Monchaud, D; Teulade-Fichou, MP | 1 |
| Bierbach, U; Choudhury, JR; Guddneppanavar, R; Kucera, GL; Saluta, G | 1 |
| Bierbach, U; Kucera, GL; Ma, Z; Saluta, G | 1 |
| Bierbach, U; Choudhury, JR; Day, CS; Kucera, GL; Ma, Z; Saluta, G; Wright, MW | 1 |
| Bierbach, U; Day, CS; Eiter, LC; Hall, NW; Kucera, GL; Saluta, G | 1 |
| Godlewska-Zyłkiewicz, B; Kojło, A; Malejko, J | 1 |
| Fukuzumi, S; Hanazaki, R; Kotani, H; Ohkubo, K; Yamada, Y | 1 |
| Cui, H; He, Y | 1 |
| Bierbach, U; Essader, AS; Kucera, GL; Levine, KE; Qiao, X; Wright, MW; Zeitany, AE | 1 |
| Blache, Y; Bouyer, F; Chauffert, B; Desbois, N; Lacaille-Dubois, MA; Moretto, J; Pertuit, D; Szollosi, A | 1 |
| Bierbach, U; Ding, S; Kucera, GL; Qiao, X | 2 |
| Bierbach, U; Ding, S; Kucera, GL; Marrs, GS; Qiao, X; Suryadi, J | 1 |
| Bierbach, U; Binz, KL; Dutta, S; Guthold, M; Roll, EH; Rosile, D; Snyder, MJ; Suryadi, J | 1 |
| Bierbach, U; Grayson, JM; Langston, PK; Parsonage, D; Poole, LB; Price, MJ; Yang, M | 1 |
| Bierbach, U; Ding, S | 1 |
| Bernish, BW; Bierbach, U; Ding, S; Donati, GL; Fahrenholtz, CD; Gross, MD; Singh, R; Wright, ML; Yang, M; Yao, X; Zheng, Y | 1 |
| Bierbach, U; Day, CS; Dhall, R; Ding, S; Fahrenholtz, CD; Gross, MD; Hackett, CL; Marrs, GS; Singh, R; Zheng, Y | 1 |
| Bertrand, HC; Bombard, S; Boussin, FD; Charif, R; Granotier-Beckers, C; Poupon, J; Ségal-Bendirdjian, E; Teulade-Fichou, MP | 1 |
| Bierbach, U; Caruso, SR; Day, CS; Rose, PK; Watkins, NH; Yao, X; Zhang, S | 1 |
| Bierbach, U; Brown-Harding, H; Watkins, NH; Yao, X | 1 |
| Bierbach, U; Ding, S; Hackett, CL; Hackett, RG; Liu, F | 1 |
| Bierbach, U; Yao, X | 1 |
| Bierbach, U; Wu, H | 1 |
| Bierbach, U; Chen, J; Day, CS; Mancera-Ortiz, IY; Slade, TA; Yao, X; Zhang, S | 1 |
1 trial(s) available for platinum and acridines
| Article | Year |
|---|---|
A phase I and pharmacologic study of pyrazoloacridine (NSC 366140) and carboplatin in patients with advanced cancer.
Topics: Acridines; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; DNA Adducts; Drug Interactions; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasms; Neutropenia; Platinum; Pyrazoles | 2002 |
31 other study(ies) available for platinum and acridines
| Article | Year |
|---|---|
The interaction of an anti-tumour platinum complex with DNA.
Topics: Acridines; Binding, Competitive; Chemical Phenomena; Chemistry; DNA; Escherichia coli; Organometallic Compounds; Platinum | 1977 |
The use of bidirectional transcription footprinting to detect platinum-DNA crosslinks by acridine-tethered platinum diamine complexes and cisplatin.
Topics: Acridines; Base Sequence; Cisplatin; Cross-Linking Reagents; DNA; Molecular Sequence Data; Molecular Structure; Platinum; Transcription, Genetic | 1993 |
Highly sensitive determination of riboflavin based on the enhanced electrogenerated chemiluminescence of lucigenin at a platinum electrode in a neutral aqueous solution.
Topics: Acridines; Electrochemistry; Electrodes; Electrolytes; Hydrogen-Ion Concentration; Luminescent Measurements; Platinum; Riboflavin; Solutions; Tablets | 2002 |
Unusual intercalation of acridin-9-ylthiourea into the 5'-GA/TC DNA base step from the minor groove: implications for the covalent DNA adduct profile of a novel platinum-intercalator conjugate.
Topics: Acridines; Base Pairing; Base Sequence; Binding, Competitive; DNA; DNA Adducts; Intercalating Agents; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Platinum; Thermodynamics; Thiourea | 2003 |
[REDUCTION OF 1,2,3,4-TETRAHYDROACRIDINE].
Topics: Acridines; Carbon; Chemistry, Pharmaceutical; Oxidation-Reduction; Palladium; Platinum; Research | 1964 |
A non-crosslinking platinum-acridine hybrid agent shows enhanced cytotoxicity compared to clinical BCNU and cisplatin in glioblastoma cells.
Topics: Acridines; Animals; Carmustine; Caspase 3; Caspases; Cell Line; Cisplatin; Cross-Linking Reagents; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glioblastoma; Inhibitory Concentration 50; Organoplatinum Compounds; Platinum | 2005 |
A platinum-quinacridine hybrid as a G-quadruplex ligand.
Topics: Acridines; Electrophoresis, Agar Gel; G-Quadruplexes; Guanine; Ligands; Molecular Structure; Organoplatinum Compounds; Platinum | 2007 |
Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: effect of metal cis/trans isomerism and DNA threading groups.
Topics: Acridines; Antineoplastic Agents; Chelating Agents; Circular Dichroism; DNA; HL-60 Cells; Humans; Intercalating Agents; Nucleic Acid Conformation; Platinum; Polydeoxyribonucleotides; Solubility; Stereoisomerism; Water | 2008 |
Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines.
Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Guanidine; HL-60 Cells; Humans; Inhibitory Concentration 50; Models, Chemical; Platinum; Structure-Activity Relationship; Thiourea; Urea | 2008 |
A non-cross-linking platinum-acridine agent with potent activity in non-small-cell lung cancer.
Topics: Acridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; DNA; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Mice; Mice, Nude; Models, Molecular; Molecular Structure; Organoplatinum Compounds; Platinum; Stereoisomerism; Structure-Activity Relationship; Time Factors | 2008 |
Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis.
Topics: Acridines; Animals; Antineoplastic Agents; Antitubercular Agents; Biological Availability; Cell Line, Tumor; Cell Proliferation; Chelating Agents; Chlorocebus aethiops; Coordination Complexes; DNA Adducts; DNA, Bacterial; Drug Screening Assays, Antitumor; Gold; Humans; Ligands; Mice; Mycobacterium tuberculosis; Organogold Compounds; Platinum; Structure-Activity Relationship; Thiourea; Urea; Vero Cells | 2009 |
A novel flow-injection method for the determination of Pt(IV) in environmental samples based on chemiluminescence reaction of lucigenin and biosorption.
Topics: Acridines; Adsorption; Air Pollutants; Chemistry Techniques, Analytical; Chlorella vulgaris; Dust; Environmental Monitoring; Equipment Design; Limit of Detection; Luminescence; Luminescent Measurements; Platinum; Poland; Reproducibility of Results | 2010 |
Size- and shape-dependent activity of metal nanoparticles as hydrogen-evolution catalysts: mechanistic insights into photocatalytic hydrogen evolution.
Topics: Acridines; Catalysis; Electrons; Hydrogen; Iron; Isotopes; Kinetics; Metal Nanoparticles; Molecular Structure; NAD; Platinum | 2011 |
Synthesis of dendritic platinum nanoparticles/lucigenin/reduced graphene oxide hybrid with chemiluminescence activity.
Topics: Acridines; Catalysis; Graphite; Luminescence; Metal Nanoparticles; Molecular Structure; Nanoparticles; Oxides; Platinum; Platinum Compounds | 2012 |
Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells.
Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cell-Free System; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cisplatin; DNA Adducts; DNA Damage; DNA, Neoplasm; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Platinum; Spectrometry, Mass, Electrospray Ionization | 2012 |
Synthesis, cytotoxicity and structure-activity relationships between ester and amide functionalities in novel acridine-based platinum(II) complexes.
Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Cytotoxins; Humans; Neoplasms; Platinum | 2012 |
Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents.
Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; DNA; Drug Design; Drug Screening Assays, Antitumor; Humans; Neoplasms; Platinum; Small Molecule Libraries; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2012 |
Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer.
Topics: Acridines; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Cell Survival; DNA; Drug Design; Female; Humans; Intercalating Agents; MCF-7 Cells; Platinum; Receptors, Estrogen; Tamoxifen | 2013 |
Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum anticancer agents.
Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Click Chemistry; DNA, Neoplasm; Fluorescent Dyes; Humans; Hydrazines; Microscopy, Confocal; Platinum | 2013 |
PT-ACRAMTU, a platinum-acridine anticancer agent, lengthens and aggregates, but does not stiffen or soften DNA.
Topics: Acridines; Antineoplastic Agents; DNA; DNA Adducts; DNA Breaks, Double-Stranded; Microscopy, Atomic Force; Organoplatinum Compounds; Particle Size; Platinum; Thiourea; Urea | 2013 |
Au-ACRAMTU-PEt3 Alters Redox Balance To Inhibit T Cell Proliferation and Function.
Topics: Acridines; Animals; Calcium; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; Lymphocyte Activation; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice, Inbred C57BL; Organogold Compounds; Oxidation-Reduction; Platinum; Urea; Viral Load | 2015 |
Linker design for the modular assembly of multifunctional and targeted platinum(ii)-containing anticancer agents.
Topics: Acridines; Amines; Antineoplastic Agents; Dendrimers; Indoles; Organophosphorus Compounds; Platinum; Quinazolines; Tamoxifen | 2016 |
Design and cellular studies of a carbon nanotube-based delivery system for a hybrid platinum-acridine anticancer agent.
Topics: Acridines; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Hyperthermia, Induced; Nanotubes, Carbon; Phototherapy; Platinum | 2016 |
Large-Pore Functionalized Mesoporous Silica Nanoparticles as Drug Delivery Vector for a Highly Cytotoxic Hybrid Platinum-Acridine Anticancer Agent.
Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coordination Complexes; Drug Carriers; Drug Liberation; Humans; Hydrogen-Ion Concentration; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Phospholipids; Platinum; Polyethylene Glycols; Porosity; Silicon Dioxide; Surface Properties | 2017 |
Association of a Platinum Complex to a G-Quadruplex Ligand Enhances Telomere Disruption.
Topics: Acridines; Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Cisplatin; Coordination Complexes; DNA Damage; G-Quadruplexes; Humans; Ligands; Microscopy, Fluorescence; Organoplatinum Compounds; Platinum; Telomere; Telomere Shortening; Telomeric Repeat Binding Protein 2 | 2017 |
Discovery of a Chiral DNA-Targeted Platinum-Acridine Agent with Potent Enantioselective Anticancer Activity.
Topics: Acridines; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coordination Complexes; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Molecular Structure; Platinum; Stereoisomerism; Structure-Activity Relationship | 2020 |
A membrane transporter determines the spectrum of activity of a potent platinum-acridine hybrid anticancer agent.
Topics: A549 Cells; Acridines; Antineoplastic Agents; Benzamides; Biphenyl Compounds; Cell Proliferation; Cell Survival; Drug Synergism; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Molecular Structure; Morpholines; Organic Cation Transport Proteins; Organoplatinum Compounds; Platinum; Pyridones; Pyrimethamine; Sulfones; Triazoles | 2020 |
Evaluation of a Platinum-Acridine Anticancer Agent and Its Liposomal Formulation in an in vivo Model of Lung Adenocarcinoma.
Topics: A549 Cells; Acridines; Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Cell Proliferation; Drug Compounding; Drug Screening Assays, Antitumor; Female; Humans; Liposomes; Lung Neoplasms; Mice; Mice, Nude; Models, Biological; Molecular Structure; Neoplasms, Experimental; Organoplatinum Compounds; Platinum | 2021 |
DNA Adduct Detection after Post-Labeling Technique with PCR Amplification (DNA-ADAPT-qPCR) Identifies the Pre-ribosomal RNA Gene as a Direct Target of Platinum-Acridine Anticancer Agents.
Topics: Acridines; Antineoplastic Agents; DNA; DNA Adducts; Genes, rRNA; Platinum; Polymerase Chain Reaction; Tandem Mass Spectrometry | 2021 |
Chemosensitivity-Gene Expression Correlations and Functional Enrichment Analysis Provide Insight into the Mechanism of Action of a Platinum-Acridine Anticancer Agent.
Topics: Acridines; Antineoplastic Agents; Cell Nucleolus; Cytotoxins; DNA; Gene Expression; Oxaliplatin; Platinum; Ribosomal Proteins; Tumor Suppressor Protein p53 | 2022 |
Development of Prodrug-Payloads for Targeted Therapeutic Applications of Platinum-Acridine Anticancer Agents.
Topics: Acridines; Antineoplastic Agents; Humans; Neoplasms; Platinum; Prodrugs | 2023 |