platensimycin has been researched along with carbene* in 2 studies
1 review(s) available for platensimycin and carbene
| Article | Year |
|---|---|
Small organometallic compounds as antibacterial agents.
The emergence of bacterial resistance to commercial antibiotics is an issue of global importance. During the last two decades, the number of antibacterial agents that have been discovered and introduced into the market has steadily declined and failed to meet the challenges posed by rapidly increasing resistance of the pathogens against common antibacterial drugs. The development of new classes of compounds to control the virulence of the pathogens is therefore urgently required. This perspective describes the historical development in brief and recent advances on the preparation of small organometallic compounds as new classes of antibacterial agents with potential for clinical development. Topics: Adamantane; Aminobenzoates; Anilides; Anti-Bacterial Agents; Methane; Organometallic Compounds; Penicillins; Quinolones | 2012 |
1 other study(ies) available for platensimycin and carbene
| Article | Year |
|---|---|
Stereoelectronic effect for the selectivity in C-H insertion of alkylidene carbenes and its application to the synthesis of platensimycin.
A systematic study of C-H insertion reactions with variously substituted and conformationally constrained substrates was carried out. High selectivity in the insertion between two competing C-H bonds caused by a strong stereoelectronic effect of an oxygen substituent was achieved. This regioselective C-H insertion reaction was employed as a platform to develop a concise asymmetric synthesis of platensimycin. Topics: Adamantane; Alkenes; Aminobenzoates; Anilides; Ethers; Ketones; Methane; Stereoisomerism | 2009 |