Page last updated: 2024-09-04

pk 9084 and diazepam

pk 9084 has been researched along with diazepam in 7 studies

Compound Research Comparison

Studies
(pk 9084)
Trials
(pk 9084)
Recent Studies (post-2010)
(pk 9084)
Studies
(diazepam)
Trials
(diazepam)
Recent Studies (post-2010) (diazepam)
170018,3772,3291,790

Protein Interaction Comparison

ProteinTaxonomypk 9084 (IC50)diazepam (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0108
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0227
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0106
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)0.0101
GABA theta subunitRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)0.0101

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19907 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
De Deyn, PP; Macdonald, RL1
Le Fur, G1
File, SE; Lister, RG1
Keane, PE; Morre, M; Simiand, J1
File, SE1
Burgevin, MC; Ferris, O; Gauthier, A; Guérémy, C; Heaulme, M; Le Fur, G; Mizoule, J; Uzan, A1
Brinton, RE; Gee, KW; Yamamura, HI1

Other Studies

7 other study(ies) available for pk 9084 and diazepam

ArticleYear
Effects of non-sedative anxiolytic drugs on responses to GABA and on diazepam-induced enhancement of these responses on mouse neurones in cell culture.
    British journal of pharmacology, 1988, Volume: 95, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Buspirone; Carbolines; Cells, Cultured; Convulsants; Diazepam; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Mice; Neurons; Pyrazoles; Quinolines; Spinal Cord

1988
[Anxiety receptors: new pharmacological approach (author's transl)].
    L'Encephale, 1982, Volume: 8, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Binding, Competitive; Brain; Chlordiazepoxide; Chlorides; Diazepam; gamma-Aminobutyric Acid; Humans; Quinolines; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures

1982
Quinolines and anxiety: anxiogenic effects of CGS 8216 and partial anxiolytic profile of PK 9084.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Diazepam; Humans; Male; Motor Activity; Pyrazoles; Quinolines; Rats; Social Behavior

1983
The quinolines PK 8165 and PK 9084 possess benzodiazepine-like activity in vitro but not in vivo.
    Neuroscience letters, 1984, Mar-09, Volume: 45, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Quinolines; Rats; Receptors, Cell Surface; Receptors, GABA-A

1984
Modification of seizures elicited by the benzodiazepine Ro 5-3663--a comparison with picrotoxin.
    The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:12

    Topics: Animals; Benzodiazepinones; Chemical Phenomena; Chemistry; Convulsants; Diazepam; Drug Synergism; Flumazenil; Male; Mice; Picrotoxin; Pyrazoles; Quinolines; Seizures

1984
Multiple benzodiazepine receptors: evidence of dissociation between anticonflict and anticonvulsant properties by PK 8165 and PK 9084 (two quinoline derivatives).
    Life sciences, 1981, Mar-30, Volume: 28, Issue:13

    Topics: Animals; Azabicyclo Compounds; Benzodiazepines; Binding, Competitive; Cerebellar Cortex; Chlordiazepoxide; Conflict, Psychological; Cyclic AMP; Cyclic GMP; Diazepam; Hypnotics and Sedatives; Kinetics; Male; Motor Activity; Piperazines; Quinolines; Rats; Receptors, Drug; Receptors, GABA-A

1981
PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam.
    Brain research, 1983, Mar-28, Volume: 264, Issue:1

    Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Diazepam; Drug Antagonism; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Quinolines; Receptors, Cell Surface; Receptors, GABA-A; Seizures

1983