Page last updated: 2024-09-04

pixantrone and mitoxantrone

pixantrone has been researched along with mitoxantrone in 12 studies

Compound Research Comparison

Studies
(pixantrone)
Trials
(pixantrone)
Recent Studies (post-2010)
(pixantrone)
Studies
(mitoxantrone)
Trials
(mitoxantrone)
Recent Studies (post-2010) (mitoxantrone)
9216594,5551,0421,004

Protein Interaction Comparison

ProteinTaxonomypixantrone (IC50)mitoxantrone (IC50)
Chain A, Probable serine/threonine-protein kinase pknBMycobacterium tuberculosis H37Rv0.8
nonstructural protein 1Influenza A virus (A/California/07/2009(H1N1))2.049
rac GTPase-activating protein 1 isoform aHomo sapiens (human)14.46
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)3.5619
Epidermal growth factor receptorHomo sapiens (human)5.3859
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.0352
Tyrosine-protein kinase FynHomo sapiens (human)1.2579
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)4.9898
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.219
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.6441
ATP-dependent translocase ABCB1Homo sapiens (human)1.501
Proto-oncogene tyrosine-protein kinase ROSHomo sapiens (human)2.9987
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.7487
DNA topoisomerase 2-alphaHomo sapiens (human)5.3
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)1.7853
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)3.5849
Casein kinase II subunit alpha'Homo sapiens (human)0.66
Sodium-dependent noradrenaline transporter Homo sapiens (human)4.9898
5-hydroxytryptamine receptor 2CHomo sapiens (human)3.5619
Multidrug resistance-associated protein 1 Homo sapiens (human)0.0081
Casein kinase II subunit betaHomo sapiens (human)0.66
Casein kinase II subunit alphaHomo sapiens (human)0.66
Tyrosine-protein kinase BTKHomo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)3.5849
TAR DNA-binding protein 43Homo sapiens (human)10
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)3.5849
Integrase Human immunodeficiency virus 15.9
Multidrug and toxin extrusion protein 2Homo sapiens (human)0.68
Casein kinase II subunit alpha 3Homo sapiens (human)0.66
Multidrug and toxin extrusion protein 1Homo sapiens (human)0.3733
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)3.39
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.9038

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (16.67)18.2507
2000's5 (41.67)29.6817
2010's4 (33.33)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Gallagher, CE; Getahun, Z; Giuliani, FC; Hacker, MP; Krapcho, AP; Landi, JJ; Maresch, MJ; Petry, ME; Polsenberg, JF; Stallman, J1
Hacker, MP; Hazlehurst, LA; Krapcho, AP1
Gonsette, RE1
Biagioli, T; Cavaletti, G; Cavalletti, E; Crippa, L; Dassi, M; Di Luccio, E; Frigo, M; Galbiati, S; Lolli, F; Mazzanti, B; Oggioni, N; Perseghin, P; Riccio, P; Rigolio, R; Rota, S; Sala, F; Sala, V; Stanzani, L; Tagliabue, E; Tredici, G; Zoia, C1
Dubois, B; Gonsette, RE1
Bellini, O; Cavagnoli, R; Cavalletti, E; Crippa, L; Mainardi, P; Oggioni, N; Sala, F1
Caccialanza, G; Carotti, A; Catto, M; Colombo, R; De Lorenzi, E; Lanni, C; Racchi, M; Verga, L1
Bilardi, RA; Buck, DP; Collins, JG; Cutts, SM; Evison, BJ; Mansour, OC; Nudelman, A; Phillips, DR; Rephaeli, A; Sleebs, BE; Watson, KG1
Chello, M; Covino, E; Menna, P; Minotti, G; Paz, OG; Salvatorelli, E; Singer, JW1
Bertoni, F; Cattan, V; Egorov, A; Han, H; Minotti, G1
Alonso Caballero, C; Barrenetxea Lekue, C; D'Amore, F; Grasso Cicala, S; Herráez Rodríguez, S; Jørgensen, JM; Leal Martínez, I; Leppä, S; Stauffer Larsen, T; Toldbod, H1
Ahonen, T; Airavaara, M; Kalso, E; Leino, S; Mätlik, K; Moreira, VM; Rinne, M; Salminen, O; Vedovi, F; Xhaard, H; Yli-Kauhaluoma, J; Zappia, G1

Reviews

4 review(s) available for pixantrone and mitoxantrone

ArticleYear
A comparison of the benefits of mitoxantrone and other recent therapeutic approaches in multiple sclerosis.
    Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:4

    Topics: Adjuvants, Immunologic; Antioxidants; Clinical Trials as Topic; Cost-Benefit Analysis; Drug Administration Schedule; Humans; Immunosuppressive Agents; Isoquinolines; Mitoxantrone; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Neuroprotective Agents

2004
Pixantrone (BBR2778): a new immunosuppressant in multiple sclerosis with a low cardiotoxicity.
    Journal of the neurological sciences, 2004, Aug-15, Volume: 223, Issue:1

    Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Heart; Humans; Immunosuppressive Agents; Immunotherapy; Isoquinolines; Mitoxantrone; Multiple Sclerosis

2004
Pixantrone: novel mode of action and clinical readouts.
    Expert review of hematology, 2018, Volume: 11, Issue:7

    Topics: Clinical Trials as Topic; Disease-Free Survival; Doxorubicin; Humans; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Mitoxantrone; Survival Rate

2018
Pixantrone beyond monotherapy: a review.
    Annals of hematology, 2019, Volume: 98, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Humans; Isoquinolines; Lymphoma, B-Cell; Mitoxantrone; Prednisone; Rituximab; Salvage Therapy; Vidarabine; Vincristine

2019

Other Studies

8 other study(ies) available for pixantrone and mitoxantrone

ArticleYear
6,9-Bis[(aminoalkyl)amino]benzo[g]isoquinoline-5,10-diones. A novel class of chromophore-modified antitumor anthracene-9,10-diones: synthesis and antitumor evaluations.
    Journal of medicinal chemistry, 1994, Mar-18, Volume: 37, Issue:6

    Topics: Adenocarcinoma; Animals; Anthraquinones; Antineoplastic Agents; Colonic Neoplasms; Humans; Isoquinolines; Leukemia L1210; Leukemia P388; Male; Mice; Mice, Inbred DBA; Mitoxantrone; Structure-Activity Relationship; Tumor Cells, Cultured

1994
Comparison of aza-anthracenedione-induced DNA damage and cytotoxicity in experimental tumor cells.
    Biochemical pharmacology, 1995, Sep-28, Volume: 50, Issue:7

    Topics: Animals; Anthraquinones; Antineoplastic Agents; Cell Division; DNA Damage; DNA, Single-Stranded; Drug Resistance; Drug Screening Assays, Antitumor; Isoquinolines; Leukemia L1210; Mitoxantrone; Proteins; Tumor Cells, Cultured

1995
Pixantrone (BBR2778) reduces the severity of experimental allergic encephalomyelitis.
    Journal of neuroimmunology, 2004, Volume: 151, Issue:1-2

    Topics: Acute Disease; Animals; Cell Division; Cells, Cultured; Chronic Disease; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Immunosuppressive Agents; Isoquinolines; Lymphocyte Count; Mitoxantrone; Rats; T-Lymphocytes

2004
Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone.
    Investigational new drugs, 2007, Volume: 25, Issue:3

    Topics: Animals; Antineoplastic Agents; Cardiomyopathies; Doxorubicin; Drug Interactions; Female; Heart; Isoquinolines; Mice; Mitoxantrone; Myocardium; Time Factors

2007
CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity.
    Electrophoresis, 2009, Volume: 30, Issue:8

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Cell Survival; Electrophoresis, Capillary; Humans; Isoquinolines; Microscopy, Electron, Transmission; Mitoxantrone; Neuroprotective Agents; Particle Size; Peptide Fragments; Plaque, Amyloid; Protein Multimerization; Spectrometry, Fluorescence; Suramin; Thiazoles

2009
New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation.
    Journal of medicinal chemistry, 2010, Oct-14, Volume: 53, Issue:19

    Topics: Anthraquinones; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; DNA Adducts; DNA-Directed RNA Polymerases; Drug Screening Assays, Antitumor; Escherichia coli Proteins; Formaldehyde; Humans; Hydrogen-Ion Concentration; Isoquinolines; Mitoxantrone; Models, Molecular; Prodrugs; Structure-Activity Relationship; Transcription, Genetic

2010
The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium: insight to explain the cardiac safety of pixantrone in doxorubicin-treated patients.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:2

    Topics: Aged; Antibiotics, Antineoplastic; Biotransformation; Chromatography, High Pressure Liquid; Doxorubicin; Drug Synergism; Female; Heart; Humans; Hydrogen Peroxide; In Vitro Techniques; Isoquinolines; Male; Mitoxantrone; Molecular Structure; Myocardium; Oxidation-Reduction; Superoxides

2013
Mitoxantrone, pixantrone and mitoxantrone (2-hydroxyethyl)piperazine are toll-like receptor 4 antagonists, inhibit NF-κB activation, and decrease TNF-alpha secretion in primary microglia.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020, Nov-01, Volume: 154

    Topics: Isoquinolines; Microglia; Mitoxantrone; NF-kappa B; Piperazine; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2020