Compounds > pixantrone
Page last updated: 2024-09-04

pixantrone and formaldehyde

pixantrone has been researched along with formaldehyde in 6 studies

Compound Research Comparison

Studies
(pixantrone)		Trials
(pixantrone)		Recent Studies (post-2010)
(pixantrone)		Studies
(formaldehyde)		Trials
(formaldehyde)		Recent Studies (post-2010) (formaldehyde)
92165922,5462435,887

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Cutts, SM; Evison, BJ; Mansour, OC; Menta, E; Phillips, DR1
Chiu, F; Cutts, SM; Evison, BJ; Pezzoni, G; Phillips, DR1
Bilardi, RA; Chiu, FC; Cutts, SM; Evison, BJ; Pezzoni, G; Phillips, DR1
Bilardi, RA; Buck, DP; Collins, JG; Cutts, SM; Evison, BJ; Mansour, OC; Nudelman, A; Phillips, DR; Rephaeli, A; Sleebs, BE; Watson, KG1
Ankers, EA; Brownlee, RTC; Cutts, SM; Evison, BJ; Phillips, DR1
Cutts, SM; Evison, BJ; Mansour, OC; Nudelman, A; Phillips, DR; Rephaeli, A1

Other Studies

6 other study(ies) available for pixantrone and formaldehyde

ArticleYear
Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent.
    Nucleic acids research, 2007, Volume: 35, Issue:11

    Topics: Antineoplastic Agents; DNA Adducts; Formaldehyde; Hydrogen-Ion Concentration; Isoquinolines; Kinetics; Temperature

2007
Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets.
    Molecular pharmacology, 2008, Volume: 74, Issue:1

    Topics: Adenine Nucleotides; Alkylating Agents; Antineoplastic Agents; Base Sequence; CpG Islands; DNA Adducts; DNA Methylation; Formaldehyde; Isoquinolines; Molecular Structure

2008
CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity.
    Nucleic acids research, 2009, Volume: 37, Issue:19

    Topics: 5-Methylcytosine; Antibiotics, Antineoplastic; Cell Line, Tumor; CpG Islands; DNA Adducts; DNA Damage; DNA Methylation; DNA-Cytosine Methylases; Doxorubicin; Formaldehyde; Humans; Isoquinolines; Mass Spectrometry

2009
New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation.
    Journal of medicinal chemistry, 2010, Oct-14, Volume: 53, Issue:19

    Topics: Anthraquinones; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; DNA Adducts; DNA-Directed RNA Polymerases; Drug Screening Assays, Antitumor; Escherichia coli Proteins; Formaldehyde; Humans; Hydrogen-Ion Concentration; Isoquinolines; Mitoxantrone; Models, Molecular; Prodrugs; Structure-Activity Relationship; Transcription, Genetic

2010
Design, synthesis, and DNA sequence selectivity of formaldehyde-mediated DNA-adducts of the novel N-(4-aminobutyl) acridine-4-carboxamide.
    Bioorganic & medicinal chemistry letters, 2014, Dec-15, Volume: 24, Issue:24

    Topics: Acridines; CpG Islands; Disinfectants; DNA Adducts; Drug Design; Formaldehyde; Isoquinolines; Models, Molecular; Molecular Structure; Topoisomerase II Inhibitors

2014
An evaluation of the interaction of pixantrone with formaldehyde-releasing drugs in cancer cells.
    Cancer chemotherapy and pharmacology, 2022, Volume: 89, Issue:6

    Topics: DNA Adducts; DNA Topoisomerases, Type II; Formaldehyde; Humans; Isoquinolines; Neoplasms; Prodrugs

2022