Page last updated: 2024-09-03

pivaloylcarnitine and carnitine

pivaloylcarnitine has been researched along with carnitine in 26 studies

Compound Research Comparison

Studies (pivaloylcarnitine)	Trials (pivaloylcarnitine)	Recent Studies (post-2010) (pivaloylcarnitine)	Studies (carnitine)	Trials (carnitine)	Recent Studies (post-2010) (carnitine)
26	1	7	9,625	750	3,016

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (3.85)	18.7374
1990's	10 (38.46)	18.2507
2000's	6 (23.08)	29.6817
2010's	9 (34.62)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Kusunoki, Y; Osana, K; Yoshioka, H	1
Hashimoto, H; Konishi, M	1
Konishi, M; Shimizu, K; Totsuka, K; Yamamoto, S	1
Matsuno, S; Mizojiri, K; Nakashima, M; Oguma, T; Uematsu, T; Yamamoto, S; Yoshida, T	1
Bieber, LL; Kerner, J; Melegh, B	1
Brørs, O; Bøhmer, T; Diep, QN	1
Bøhmer, T; Diep, QN	1
Bøhmer, T; Diep, QN; Skrede, S	1
Chiba, S; Fujii, R; Meguro, H; Mori, A; Mori, T; Numazaki, K; Satoh, Y; Sunakawa, K; Terashima, I; Toyonaga, Y	1
Melegh, B; Sherry, AD; Sumegi, B	1
Abdenur, JE; Chamoles, NA; Fuertes, AN; Guinle, AE; Schenone, AB	1
Fujigaki, M; Komiya, I; Nakayoshi, T; Okudaira, N; Sugiyama, Y	1
Brass, EP	1
Nakajima, Y; Nakamura, Y; Yamaguchi, T	1
Hasegawa, H; Norikura, R; Ohnishi, S; Okamura, N; Shimaoka, H	1
Baba, T; Hasegawa, H; Horie, K; Kanaoka, E; Norikura, R; Ohnishi, S; Okamura, N; Sakamoto, K; Sakamoto, S; Takahashi, K	1
Bodmer, M; Häussinger, D; Krähenbühl, S; Todesco, L; Vonwil, K	1
Forni, S; Fu, X; Palmer, SE; Sweetman, L	1
Ichiki, S; Ito, T; Kurono, Y; Maeda, Y; Makino, Y; Mizuno, M; Nakajima, Y; Sugiura, T; Sugiyama, N; Togari, H	1
Janzen, N; Peter, M; Sander, J; Sander, S; Steuerwald, U; Terhardt, M	1
Boemer, F; de Halleux, V; Debray, FG; Kalenga, M; Schoos, R	1
Boemer, F; Dayaldasani, A; Rueda, I; Yahyaoui, R	1
Bo, R; Hasegawa, Y; Ishige, N; Kobayashi, H; Nakamura, M; Takahashi, T; Yamada, K; Yamaguchi, S	1
Fukuda, S; Hasegawa, Y; Kobayashi, H; Purevsuren, J; Takahashi, T; Yamada, K; Yamaguchi, S	1
Hoppel, CL; Ingalls, ST; Minkler, PE; Stoll, MSK	1
Fuchigami, T; Ishige, M; Ishige, N; Nakazaki, K; Ogawa, E; Takahashi, S	1

Reviews

1 review(s) available for pivaloylcarnitine and carnitine

Article	Year
Pivalate-generating prodrugs and carnitine homeostasis in man. Pharmacological reviews, 2002, Volume: 54, Issue:4 Topics: Animals; Carnitine; Homeostasis; Humans; Pentanoic Acids; Prodrugs; Tissue Distribution	2002

Trials

1 trial(s) available for pivaloylcarnitine and carnitine

Article	Year
Phase I clinical studies of S-1108: safety and pharmacokinetics in a multiple-administration study with special emphasis on the influence on carnitine body stores. Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:4 Topics: Adult; Carnitine; Cephalosporins; Drug Administration Schedule; Drug Evaluation; Humans; Male; Pentanoic Acids; Tablets	1992

Other Studies

24 other study(ies) available for pivaloylcarnitine and carnitine

Article	Year
[Identification of pivaloylcarnitine in urine of patients with pivoxil therapy]. No to hattatsu = Brain and development, 1992, Volume: 24, Issue:5 Topics: Administration, Oral; Adolescent; Carnitine; Cefmenoxime; Humans; Urinary Tract Infections	1992
Determination of pivaloylcarnitine in human plasma and urine by high-performance liquid chromatography with fluorescence detection. Journal of pharmaceutical sciences, 1992, Volume: 81, Issue:10 Topics: Calibration; Carnitine; Cephalosporins; Chromatography, High Pressure Liquid; Drug Stability; Humans; Pentanoic Acids; Prodrugs; Quinoxalines; Sensitivity and Specificity; Spectrometry, Fluorescence	1992
Metabolism of S-1108, a new oral cephem antibiotic, and metabolic profiles of its metabolites in humans. Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:4 Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Carnitine; Cephalosporins; Humans; Male; Pentanoic Acids	1992
Pivampicillin-promoted excretion of pivaloylcarnitine in humans. Biochemical pharmacology, 1987, Oct-15, Volume: 36, Issue:20 Topics: Acetylcarnitine; Adolescent; Ampicillin; Carnitine; Child; Female; Humans; Kidney; Male; Pentanoic Acids; Pivampicillin	1987
Formation of pivaloylcarnitine in isolated rat heart cells. Biochimica et biophysica acta, 1995, Nov-16, Volume: 1259, Issue:2 Topics: Acetylcarnitine; Animals; Betaine; Carnitine; Cells, Cultured; Kinetics; Myocardium; Pentanoic Acids; Pivampicillin; Rats; Rats, Wistar	1995
Increased pivaloylcarnitine in the liver of the sodium pivalate treated rat exposed to clofibrate. Biochimica et biophysica acta, 1995, May-17, Volume: 1256, Issue:2 Topics: Adipose Tissue, Brown; Animals; Carnitine; Carnitine O-Acetyltransferase; Clofibrate; Heart; Liver; Male; Pentanoic Acids; Rats; Rats, Wistar; Triglycerides	1995
Formation of pivaloylcarnitine in heart and brown adipose tissue in the rat. Biochimica et biophysica acta, 1995, Jan-18, Volume: 1243, Issue:1 Topics: Adipose Tissue, Brown; Animals; Carbon Radioisotopes; Carnitine; Chromatography, Gas; Isotope Labeling; Male; Myocardium; Pentanoic Acids; Rats; Rats, Wistar; Tissue Distribution	1995
[Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients]. The Japanese journal of antibiotics, 1993, Volume: 46, Issue:10 Topics: Bacterial Infections; Carnitine; Cephalosporins; Child; Child, Preschool; Female; Humans; Infant; Male; Pentanoic Acids	1993
Preferential elimination of pivalate with supplemental carnitine via formation of pivaloylcarnitine in man. Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:11 Topics: Adolescent; Carnitine; Child; Chromatography, Gas; Drug Interactions; Esters; Female; Humans; Magnetic Resonance Spectroscopy; Male; Pentanoic Acids; Pivampicillin	1993
Diagnosis of isovaleric acidaemia by tandem mass spectrometry: false positive result due to pivaloylcarnitine in a newborn screening programme. Journal of inherited metabolic disease, 1998, Volume: 21, Issue:6 Topics: Carnitine; False Positive Reactions; Female; Gas Chromatography-Mass Spectrometry; Hemiterpenes; Humans; Infant, Newborn; Mass Spectrometry; Metabolism, Inborn Errors; Neonatal Screening; Pentanoic Acids; Sulbactam; Urinary Tract Infections	1998
Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid. Pharmaceutical research, 2001, Volume: 18, Issue:4 Topics: Animals; Carnitine; Carrier Proteins; Injections, Intra-Arterial; Injections, Intravenous; Male; Organic Cation Transport Proteins; Pentanoic Acids; Rats; Rats, Sprague-Dawley; Solute Carrier Family 22 Member 5; Tissue Distribution; Up-Regulation	2001
Possible mechanism for species difference on the toxicity of pivalic acid between dogs and rats. Toxicology and applied pharmacology, 2006, Jul-01, Volume: 214, Issue:1 Topics: Acyl Coenzyme A; Animals; Anti-Bacterial Agents; Carnitine; Dogs; In Vitro Techniques; Kidney; Male; Mitochondria; Muscle, Skeletal; Pentanoic Acids; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity	2006
Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid. Pharmaceutical research, 2006, Volume: 23, Issue:8 Topics: Acetylcarnitine; Algorithms; Amino Acid Transport Systems, Basic; Animals; Biological Transport, Active; Carnitine; Carrier Proteins; Enzyme Inhibitors; LLC-PK1 Cells; Pentanoic Acids; Swine; Valproic Acid	2006
Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment. Drug metabolism and pharmacokinetics, 2008, Volume: 23, Issue:4 Topics: Animals; Carnitine; CHO Cells; Cricetinae; Cricetulus; Humans; Kidney; Male; Organic Cation Transport Proteins; Pentanoic Acids; Prodrugs; Rats; Rats, Sprague-Dawley; Sodium; Solute Carrier Family 22 Member 5; Valproic Acid	2008
Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2. Chemico-biological interactions, 2009, Aug-14, Volume: 180, Issue:3 Topics: Animals; Biological Transport; Carnitine; Cell Line; Humans; Kinetics; Organic Cation Transport Proteins; Pentanoic Acids; Rats; Solute Carrier Family 22 Member 5	2009
Rapid determination of C4-acylcarnitine and C5-acylcarnitine isomers in plasma and dried blood spots by UPLC-MS/MS as a second tier test following flow-injection MS/MS acylcarnitine profile analysis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Carnitine; Chromatography, Liquid; Humans; Infant, Newborn; Isomerism; Neonatal Screening; Tandem Mass Spectrometry	2010
Detection of pivaloylcarnitine in pediatric patients with hypocarnitinemia after long-term administration of pivalate-containing antibiotics. The Tohoku journal of experimental medicine, 2010, Volume: 221, Issue:4 Topics: Anti-Bacterial Agents; Carnitine; Cephalosporins; Chromatography, High Pressure Liquid; Humans; Infant; Male; Tandem Mass Spectrometry; Treatment Outcome	2010
UPLC-MS/MS analysis of C5-acylcarnitines in dried blood spots. Clinica chimica acta; international journal of clinical chemistry, 2013, Jun-05, Volume: 421 Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Chromatography, High Pressure Liquid; Diagnosis, Differential; Dried Blood Spot Testing; Humans; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Limit of Detection; Neonatal Screening; Reproducibility of Results; Tandem Mass Spectrometry	2013
Surprising causes of C5-carnitine false positive results in newborn screening. Molecular genetics and metabolism, 2014, Volume: 111, Issue:1 Topics: Amino Acid Metabolism, Inborn Errors; Belgium; Carnitine; False Positive Reactions; Humans; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Mass Spectrometry; Neonatal Screening; Ointments; Pentanoic Acids; Prodrugs; Risk Factors	2014
[C5-carnitine false positive results in newborn screening: what is the cause?]. Medicina clinica, 2015, Feb-20, Volume: 144, Issue:4 Topics: Amino Acid Metabolism, Inborn Errors; Biotransformation; Breast Feeding; Carnitine; Coenzyme A Ligases; Cosmetics; False Positive Reactions; Female; Humans; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Maternal-Fetal Exchange; Neonatal Screening; Ointments; Pentanoic Acids; Pregnancy; Tandem Mass Spectrometry	2015
Elevation of pivaloylcarnitine by sivelestat sodium in two children. Molecular genetics and metabolism, 2015, Volume: 116, Issue:3 Topics: Amino Acid Metabolism, Inborn Errors; Cardiomyopathies; Carnitine; Child, Preschool; Chromatography, Liquid; Female; Glycine; Humans; Hyperammonemia; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Muscular Diseases; Neonatal Screening; Serine Proteinase Inhibitors; Sulfonamides; Tandem Mass Spectrometry	2015
Clinical Features of Carnitine Deficiency Secondary to Pivalate-Conjugated Antibiotic Therapy. The Journal of pediatrics, 2016, Volume: 173 Topics: Adolescent; Adult; Anti-Bacterial Agents; Brain Diseases; Carnitine; Child; Child, Preschool; Female; Humans; Hypoglycemia; Infant; Male; Retrospective Studies; Tandem Mass Spectrometry; Young Adult	2016
Selective and accurate C5 acylcarnitine quantitation by UHPLC-MS/MS: Distinguishing true isovaleric acidemia from pivalate derived interference. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017, Sep-01, Volume: 1061-1062 Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Chromatography, High Pressure Liquid; Humans; Isovaleryl-CoA Dehydrogenase; Limit of Detection; Reproducibility of Results; Tandem Mass Spectrometry	2017
Hypocarnitinemia Observed in an Infant Treated with Short-Term Administration of Antibiotic Containing Pivalic Acid. The Tohoku journal of experimental medicine, 2018, Volume: 244, Issue:4 Topics: Anti-Bacterial Agents; Carbon; Carnitine; Humans; Hypoglycemia; Infant; Male; Metabolic Diseases; Oxygen; Pentanoic Acids; Tandem Mass Spectrometry	2018