pivalic acid has been researched along with carnitine in 50 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (8.00) | 18.7374 |
1990's | 26 (52.00) | 18.2507 |
2000's | 15 (30.00) | 29.6817 |
2010's | 5 (10.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
Hashimoto, H; Konishi, M | 1 |
Konishi, M; Shimizu, K; Totsuka, K; Yamamoto, S | 1 |
Matsuno, S; Mizojiri, K; Nakashima, M; Oguma, T; Uematsu, T; Yamamoto, S; Yoshida, T | 1 |
Holme, E; Jodal, U; Linstedt, S; Nordin, I | 1 |
Bianchi, PB; Davis, AT | 2 |
Greter, J; Holme, E; Jacobson, CE; Jodal, U; Kristiansson, B; Lindstedt, S; Nordin, I | 1 |
Melegh, B | 1 |
Bieber, LL; Kerner, J; Melegh, B | 1 |
Arison, BH; Duncan, CA; Flynn, H; Ramjit, HG; Smith, JL; Vickers, S; Walker, RW; White, SD | 1 |
Christos, SC; DiDomenico, DF; Morris, GS; Paulson, DJ; Shug, AL; Wolf, BA; Zhou, Q | 1 |
Brørs, O; Bøhmer, T; Diep, QN | 1 |
Abrahamsson, K; Holme, E; Jodal, U; Lindstedt, S; Nordin, I | 1 |
Broderick, TL; DiDomenico, D; Paulson, DJ; Shug, AL | 1 |
Broderick, TL; Christos, SC; DiDomenico, D; Paulson, DJ; Shug, AL; Wolf, BA | 1 |
Bøhmer, T; Diep, QN | 1 |
Bøhmer, T; Diep, QN; Skrede, S | 1 |
Abrahamsson, K; Eriksson, BO; Holme, E; Jodal, U; Lindstedt, S; Nordin, I | 1 |
Chiba, S; Fujii, R; Meguro, H; Mori, A; Mori, T; Numazaki, K; Satoh, Y; Sunakawa, K; Terashima, I; Toyonaga, Y | 1 |
Melegh, B; Sherry, AD; Sumegi, B | 1 |
Fujita, Y; Hiraga, Y; Inamatsu, T; Nishikawa, T; Ohmichi, M; Saito, A; Shimada, J; Shimada, K; Shimizu, K; Tanimura, M | 1 |
Davis, AT | 1 |
Abrahamsson, K; Eriksson, BO; Holme, E; Jodal, U; Jönsson, A; Lindstedt, S; Mellander, M | 1 |
Broderick, TL; DiDomenico, D; Gamble, J; Lopaschuk, GD; Panagakis, G; Paulson, DJ; Shug, AL | 1 |
Inoue, F; Kinugasa, A; Kizaki, Z; Kodo, N; Nakajima, H; Nukina, S; Sawada, T | 1 |
Bianchi, PB; Davis, AT; Lehotay, DC | 1 |
Abrahamsson, K; Eriksson, BO; Holme, E; Jodal, U; Jönsson, A; Lindstedt, S | 1 |
Cooper, TG; Lewin, LM; Wang, XS; Yeung, CH | 1 |
Cooper, T; Fournier-Delpech, S; Golan, R; Lewin, LM; Pholpramool, C; Shochat, L; Weissenberg, R | 1 |
Bröer, A; Bröer, S; Kaltenbach, S; Lang, F; Lükewille, U; Moschen, I; Risler, T; Wagner, CA | 1 |
Arrigoni-Martelli, E; Caso, V | 1 |
Fujigaki, M; Komiya, I; Nakayoshi, T; Okudaira, N; Sugiyama, Y | 1 |
Arduini, A; Carminati, P; Ricciolini, R; Scalibastri, M | 1 |
Brass, EP | 1 |
Stanley, CA | 1 |
Davis, AT; Monroe, TJ | 1 |
Nakajima, Y; Nakamura, Y; Yamaguchi, T | 1 |
Broderick, TL | 1 |
Hasegawa, H; Norikura, R; Ohnishi, S; Okamura, N; Shimaoka, H | 1 |
Doberenz, J; Eder, K; Hirche, F; Keller, U | 1 |
Ito, T; Koyama, N; Makino, Y; Sugiura, T; Sugiyama, N | 1 |
Baba, T; Hasegawa, H; Horie, K; Kanaoka, E; Norikura, R; Ohnishi, S; Okamura, N; Sakamoto, K; Sakamoto, S; Takahashi, K | 1 |
Bodmer, M; Häussinger, D; Krähenbühl, S; Todesco, L; Vonwil, K | 1 |
Ito, T | 1 |
Djurhuus, H; Køber, L; Lund, AM; Nielsen, OW; Rasmussen, J | 1 |
Boemer, F; de Halleux, V; Debray, FG; Kalenga, M; Schoos, R | 1 |
Boemer, F; Dayaldasani, A; Rueda, I; Yahyaoui, R | 1 |
Kubota, M; Nasu, T; Suzuki, M; Uetake, K | 1 |
Fuchigami, T; Ishige, M; Ishige, N; Nakazaki, K; Ogawa, E; Takahashi, S | 1 |
5 review(s) available for pivalic acid and carnitine
Article | Year |
---|---|
Carnitine protects mitochondria and removes toxic acyls from xenobiotics.
Topics: Acyl Coenzyme A; Ammonia; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Antineoplastic Agents; Bacterial Toxins; Carnitine; Humans; Mitochondria; Pentanoic Acids; Peroxisome Proliferators; Valproic Acid; Xenobiotics | 2001 |
Pivalate-generating prodrugs and carnitine homeostasis in man.
Topics: Animals; Carnitine; Homeostasis; Humans; Pentanoic Acids; Prodrugs; Tissue Distribution | 2002 |
Carnitine deficiency disorders in children.
Topics: Anti-Bacterial Agents; Carnitine; Child, Preschool; Fatty Acids; Humans; Mutation; Organic Cation Transport Proteins; Oxidation-Reduction; Pentanoic Acids; Solute Carrier Family 22 Member 5 | 2004 |
Hypocarnitinaemia induced by sodium pivalate in the rat is associated with left ventricular dysfunction and impaired energy metabolism.
Topics: Animals; Carnitine; Energy Metabolism; Models, Animal; Myocardium; Pentanoic Acids; Rats; Ventricular Dysfunction, Left | 2006 |
Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism.
Topics: Amidohydrolases; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carnitine; Cephalosporins; Child; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Humans; Intestinal Absorption; Pentanoic Acids; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Rats | 2009 |
2 trial(s) available for pivalic acid and carnitine
Article | Year |
---|---|
Phase I clinical studies of S-1108: safety and pharmacokinetics in a multiple-administration study with special emphasis on the influence on carnitine body stores.
Topics: Adult; Carnitine; Cephalosporins; Drug Administration Schedule; Drug Evaluation; Humans; Male; Pentanoic Acids; Tablets | 1992 |
Impaired ketogenesis in carnitine depletion caused by short-term administration of pivalic acid prodrug.
Topics: Adult; Amdinocillin Pivoxil; Carnitine; Fatty Acids; Fatty Acids, Nonesterified; Humans; Ketone Bodies; Liver; Male; Muscle, Skeletal; Oxidation-Reduction; Pentanoic Acids; Prodrugs | 1994 |
43 other study(ies) available for pivalic acid and carnitine
Article | Year |
---|---|
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
Determination of pivaloylcarnitine in human plasma and urine by high-performance liquid chromatography with fluorescence detection.
Topics: Calibration; Carnitine; Cephalosporins; Chromatography, High Pressure Liquid; Drug Stability; Humans; Pentanoic Acids; Prodrugs; Quinoxalines; Sensitivity and Specificity; Spectrometry, Fluorescence | 1992 |
Metabolism of S-1108, a new oral cephem antibiotic, and metabolic profiles of its metabolites in humans.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Carnitine; Cephalosporins; Humans; Male; Pentanoic Acids | 1992 |
Effects of pivalic acid-containing prodrugs on carnitine homeostasis and on response to fasting in children.
Topics: Amdinocillin Pivoxil; Carnitine; Child; Child, Preschool; Fasting; Female; Homeostasis; Humans; Muscles; Pentanoic Acids; Pivampicillin; Prodrugs; Reference Values | 1992 |
Sodium pivalate treatment reduces tissue carnitines and enhances ketosis in rats.
Topics: Animals; Carnitine; Chromatography, High Pressure Liquid; Ketosis; Liver; Male; Pentanoic Acids; Rats; Rats, Inbred Strains; Tissue Distribution | 1991 |
Carnitine deficiency induced by pivampicillin and pivmecillinam therapy.
Topics: Adolescent; Adult; Amdinocillin; Amdinocillin Pivoxil; Ampicillin; Carnitine; Child; Child, Preschool; Chromatography, Gas; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Infant; Male; Mass Spectrometry; Muscles; Pentanoic Acids; Pivampicillin; Time Factors; Urinary Tract Infections | 1989 |
Carnitine supplementation in pivampicillin treatment.
Topics: Ampicillin; Carnitine; Child; Humans; Pentanoic Acids; Pivampicillin | 1989 |
Pivampicillin-promoted excretion of pivaloylcarnitine in humans.
Topics: Acetylcarnitine; Adolescent; Ampicillin; Carnitine; Child; Female; Humans; Kidney; Male; Pentanoic Acids; Pivampicillin | 1987 |
Carnitine and glucuronic acid conjugates of pivalic acid.
Topics: Animals; Carnitine; Chromatography, Thin Layer; Glucuronates; Glucuronic Acid; Humans; Hydrolysis; Macaca fascicularis; Male; Methyldopa; Pentanoic Acids; Scintillation Counting; Spectrum Analysis; Valerates | 1985 |
Sodium pivalate reduces cardiac carnitine content and increases glucose oxidation without affecting cardiac functional capacity.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Carnitine; Citrate (si)-Synthase; Glucose; Heart; Hexokinase; Isoenzymes; Male; Myocardium; Myosins; Oxidation-Reduction; Pentanoic Acids; Rats; Rats, Sprague-Dawley | 1995 |
Formation of pivaloylcarnitine in isolated rat heart cells.
Topics: Acetylcarnitine; Animals; Betaine; Carnitine; Cells, Cultured; Kinetics; Myocardium; Pentanoic Acids; Pivampicillin; Rats; Rats, Wistar | 1995 |
Effect of short-term treatment with pivalic acid containing antibiotics on serum carnitine concentration--a risk irrespective of age.
Topics: Adolescent; Adult; Age Factors; Aged; Amdinocillin Pivoxil; Carnitine; Female; Humans; Male; Middle Aged; Norfloxacin; Penicillins; Pentanoic Acids; Prodrugs; Risk Factors; Time Factors; Urinary Tract Infections | 1995 |
L-propionylcarnitine effects on cardiac carnitine content and function in secondary carnitine deficiency.
Topics: Animals; Aorta; Blood Pressure; Cardiotonic Agents; Carnitine; Heart; Heart Rate; In Vitro Techniques; Male; Myocardium; Pentanoic Acids; Perfusion; Rats; Rats, Sprague-Dawley | 1995 |
Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Carnitine; Esters; Fatty Acids; Glucose; Heart; Lipids; Male; Myocardium; Oxidation-Reduction; Palmitates; Pentanoic Acids; Rats; Rats, Sprague-Dawley | 1995 |
Increased pivaloylcarnitine in the liver of the sodium pivalate treated rat exposed to clofibrate.
Topics: Adipose Tissue, Brown; Animals; Carnitine; Carnitine O-Acetyltransferase; Clofibrate; Heart; Liver; Male; Pentanoic Acids; Rats; Rats, Wistar; Triglycerides | 1995 |
Formation of pivaloylcarnitine in heart and brown adipose tissue in the rat.
Topics: Adipose Tissue, Brown; Animals; Carbon Radioisotopes; Carnitine; Chromatography, Gas; Isotope Labeling; Male; Myocardium; Pentanoic Acids; Rats; Rats, Wistar; Tissue Distribution | 1995 |
[Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients].
Topics: Bacterial Infections; Carnitine; Cephalosporins; Child; Child, Preschool; Female; Humans; Infant; Male; Pentanoic Acids | 1993 |
Preferential elimination of pivalate with supplemental carnitine via formation of pivaloylcarnitine in man.
Topics: Adolescent; Carnitine; Child; Chromatography, Gas; Drug Interactions; Esters; Female; Humans; Magnetic Resonance Spectroscopy; Male; Pentanoic Acids; Pivampicillin | 1993 |
Carnitine status and safety after administration of S-1108, a new oral cephem, to patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Bacterial Infections; Carnitine; Cephalosporins; Female; Humans; Kidney Diseases; Male; Middle Aged; Pentanoic Acids; Prodrugs | 1993 |
Carnitine depletion in rat pups of lactating mothers given sodium pivalate.
Topics: Animals; Carnitine; Female; Lactation; Liver; Milk; Myocardium; Pentanoic Acids; Pregnancy; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1995 |
Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid.
Topics: Adolescent; Adult; Amdinocillin Pivoxil; Anti-Bacterial Agents; Carnitine; Echocardiography; Female; Heart Septum; Humans; Male; Middle Aged; Muscle, Skeletal; Myocardium; Pentanoic Acids; Time Factors | 1995 |
L-carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts.
Topics: Animals; Carnitine; Fatty Acids; Glucose; Glycolysis; Male; Myocardium; Oxidation-Reduction; Pentanoic Acids; Perfusion; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
Pivalate affects carnitine status but causes no severe metabolic changes in rat liver.
Topics: 3-Hydroxybutyric Acid; Animals; Carnitine; Fatty Acids, Nonesterified; Gluconeogenesis; Heart; Hydroxybutyrates; Ketone Bodies; Lactates; Lactic Acid; Liver; Male; Muscles; Myocardium; Pentanoic Acids; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar | 1996 |
beta-Hydroxybutyrate oxidation is reduced and hepatic balance of ketone bodies and free fatty acids is unaltered in carnitine-depleted, pivalate-treated rats.
Topics: 3-Hydroxybutyric Acid; Animals; Body Weight; Carbon Dioxide; Carbon Radioisotopes; Carnitine; Fatty Acids, Nonesterified; Female; Hydroxybutyrates; Ketone Bodies; Ketones; Liver; Male; Oxidation-Reduction; Pentanoic Acids; Rats; Rats, Sprague-Dawley | 1996 |
Carnitine supplementation ameliorates the steatosis and ketosis induced by pivalate in rats.
Topics: 3-Hydroxybutyric Acid; Animals; Carbonates; Carnitine; Dicarboxylic Acids; Fatty Acids; Food, Fortified; Hydroxybutyrates; Ketones; Lipid Metabolism; Liver; Male; Muscle, Skeletal; Myocardium; Oxidation-Reduction; Pentanoic Acids; Rats; Rats, Sprague-Dawley; Triglycerides; Weight Gain | 1996 |
Pivalic acid-induced carnitine deficiency and physical exercise in humans.
Topics: Adolescent; Adult; Amdinocillin Pivoxil; Blood Glucose; Carnitine; Exercise; Fatty Acids, Nonesterified; Female; Glycogen; Humans; Male; Middle Aged; Pentanoic Acids; Pivampicillin; Triglycerides | 1996 |
Successful lowering of epididymal carnitine by administration of pivalate to rats.
Topics: Animals; Carnitine; Epididymis; Female; Fertility; Kidney; Liver; Male; Myocardium; Ovariectomy; Pentanoic Acids; Rats; Sperm Motility; Time Factors; Water Supply | 1997 |
Effects of pivalic acid and sodium pivalate on L-carnitine concentrations in the cauda epididymidis and on male fertility in the hamster.
Topics: Animals; Carnitine; Chromatin; Cricetinae; Epididymis; Fertility; Male; Mesocricetus; Pentanoic Acids; Sperm Motility | 1997 |
Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2.
Topics: Amino Acids; Animals; Betaine; Biological Transport; Carnitine; Carrier Proteins; Emetine; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Lipotropic Agents; Membrane Potentials; Membrane Proteins; Microinjections; Oocytes; Organic Cation Transport Proteins; Patch-Clamp Techniques; Pentanoic Acids; Protein Synthesis Inhibitors; RNA, Complementary; Sodium; Solute Carrier Family 22 Member 5; Tetraethylammonium; Tritium; Valproic Acid; Xenopus laevis | 2000 |
Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid.
Topics: Animals; Carnitine; Carrier Proteins; Injections, Intra-Arterial; Injections, Intravenous; Male; Organic Cation Transport Proteins; Pentanoic Acids; Rats; Rats, Sprague-Dawley; Solute Carrier Family 22 Member 5; Tissue Distribution; Up-Regulation | 2001 |
The effect of pivalate treatment of pregnant rats on body mass and insulin levels in the adult offspring.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Blood Glucose; Carnitine; Female; Hyperinsulinism; Insulin; Insulin Resistance; Lactation; Male; Maternal-Fetal Exchange; Obesity; Pentanoic Acids; Pregnancy; Prodrugs; Rats; Triglycerides | 2001 |
Carnitine deficiency and supplementation do not affect the gene expression of carnitine biosynthetic enzymes in rats.
Topics: Animals; Carnitine; Dietary Supplements; gamma-Butyrobetaine Dioxygenase; Gene Expression Regulation; Kidney; Liver; Lysine; Male; Mixed Function Oxygenases; Pentanoic Acids; Rats; RNA, Messenger | 2005 |
Possible mechanism for species difference on the toxicity of pivalic acid between dogs and rats.
Topics: Acyl Coenzyme A; Animals; Anti-Bacterial Agents; Carnitine; Dogs; In Vitro Techniques; Kidney; Male; Mitochondria; Muscle, Skeletal; Pentanoic Acids; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity | 2006 |
Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid.
Topics: Acetylcarnitine; Algorithms; Amino Acid Transport Systems, Basic; Animals; Biological Transport, Active; Carnitine; Carrier Proteins; Enzyme Inhibitors; LLC-PK1 Cells; Pentanoic Acids; Swine; Valproic Acid | 2006 |
Pivalate lowers litter sizes and weights in female rats independent of its effect on carnitine status.
Topics: Animals; Animals, Newborn; Body Weight; Carnitine; Female; Fertilization; Litter Size; Pentanoic Acids; Pregnancy; Rats; Rats, Sprague-Dawley; Vitamin B Deficiency | 2007 |
Carnitine-associated encephalopathy caused by long-term treatment with an antibiotic containing pivalic acid.
Topics: Acidosis; Anti-Bacterial Agents; Brain Diseases, Metabolic; Carnitine; Cephalosporins; Humans; Hypoglycemia; Infant; Infusions, Intravenous; Male; Otitis Media; Pentanoic Acids; Seizures; Unconsciousness; Vitamin B Complex | 2007 |
Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment.
Topics: Animals; Carnitine; CHO Cells; Cricetinae; Cricetulus; Humans; Kidney; Male; Organic Cation Transport Proteins; Pentanoic Acids; Prodrugs; Rats; Rats, Sprague-Dawley; Sodium; Solute Carrier Family 22 Member 5; Valproic Acid | 2008 |
Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2.
Topics: Animals; Biological Transport; Carnitine; Cell Line; Humans; Kinetics; Organic Cation Transport Proteins; Pentanoic Acids; Rats; Solute Carrier Family 22 Member 5 | 2009 |
Primary carnitine deficiency and pivalic acid exposure causing encephalopathy and fatal cardiac events.
Topics: Adult; Anti-Bacterial Agents; Arrhythmias, Cardiac; Cardiomyopathies; Carnitine; Child, Preschool; Death, Sudden, Cardiac; Female; Humans; Hyperammonemia; Infant; Muscular Diseases; Pentanoic Acids; Retrospective Studies | 2013 |
Surprising causes of C5-carnitine false positive results in newborn screening.
Topics: Amino Acid Metabolism, Inborn Errors; Belgium; Carnitine; False Positive Reactions; Humans; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Mass Spectrometry; Neonatal Screening; Ointments; Pentanoic Acids; Prodrugs; Risk Factors | 2014 |
[C5-carnitine false positive results in newborn screening: what is the cause?].
Topics: Amino Acid Metabolism, Inborn Errors; Biotransformation; Breast Feeding; Carnitine; Coenzyme A Ligases; Cosmetics; False Positive Reactions; Female; Humans; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Maternal-Fetal Exchange; Neonatal Screening; Ointments; Pentanoic Acids; Pregnancy; Tandem Mass Spectrometry | 2015 |
Newborn hypocarnitinemia due to long-term transplacental pivalic acid passage.
Topics: Carnitine; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Metabolism, Inborn Errors; Pentanoic Acids; Pregnancy; Time Factors | 2014 |
Hypocarnitinemia Observed in an Infant Treated with Short-Term Administration of Antibiotic Containing Pivalic Acid.
Topics: Anti-Bacterial Agents; Carbon; Carnitine; Humans; Hypoglycemia; Infant; Male; Metabolic Diseases; Oxygen; Pentanoic Acids; Tandem Mass Spectrometry | 2018 |