pituitrin has been researched along with spiradoline* in 2 studies
1 review(s) available for pituitrin and spiradoline
| Article | Year |
|---|---|
Kappa agonists and vasopressin secretion.
The effects of opiates on vasopressin secretion have been controversial for many years. This is probably due to the existence of different types of opioid receptors and to the lack of specificity of the compounds used. Specific kappa agonists, which have been described recently, produce a marked diuretic effect without any associated increase in electrolyte elimination. They seem to exert their effects through an interaction with kappa receptors situated on nerve terminals and/or pituicytes. These receptors could be directly coupled to L-type calcium channels, their activation leading to a decrease in the effectiveness of action potentials to evoke vasopressin secretion from nerve terminals in the neurohypophysis. This mechanism of action may explain the decrease in plasma vasopressin levels induced by kappa agonists. Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Diuretics; Paraventricular Hypothalamic Nucleus; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Supraoptic Nucleus; Vasopressins | 1990 |
1 trial(s) available for pituitrin and spiradoline
| Article | Year |
|---|---|
Mechanism of diuretic action of spiradoline (U-62066E)--a kappa opioid receptor agonist in the human.
1. The mechanism of the diuretic effect of the kappa opioid receptor agonist spiradoline was investigated in 10 healthy male subjects in a placebo-controlled, double-blind cross-over study. 2. Urine volume and osmolality, plasma vasopressin and Doppler renal blood velocity indices were recorded for 1.25 h before and 6 h following injection. 3. Spiradoline caused a significant increase in urine output which was antagonized by high but not low dose naloxone. The urine increase was accompanied by a significant decrease in osmolality which was also antagonised by high but not low dose naloxone. 4. Spiradoline had no effect on plasma vasopressin concentration or on renal blood velocity indices. 5. We conclude that kappa agonists induce diuresis in humans by a mechanism not involving suppression of vasopressin or changes in renal blood velocity indices. Topics: Adult; Blood Flow Velocity; Diuresis; Diuretics; Double-Blind Method; Humans; Male; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Renal Circulation; Urodynamics; Vasopressins | 1991 |