pituitrin and phorbol

pituitrin has been researched along with phorbol* in 1 studies

Other Studies

1 other study(ies) available for pituitrin and phorbol

Article	Year
Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets. FEBS letters, 1985, Jan-28, Volume: 180, Issue:2 Tumour-promoting phorbol esters (phorbol-12-myristate-13-acetate, PMA; phorbol-12,13-dibutyrate, PDBu) but not 4 beta-phorbol, activate protein kinase C. Using human platelets pre-labelled with quin2 or 32PO4 we examined the effects of these compounds on human platelet cytosolic free Ca2+ ([Ca2+]i) and on [32P]phosphatidic acid ([32P]PtdOH). PMA and PDBu, but not 4 beta-phorbol inhibited thrombin-, PAF- and vasopressin-induced elevation of [Ca2+]i and [32P]PtdOH formation. It is suggested that protein kinase C may act to terminate the transduction processes that link receptor occupancy to cellular activation. Topics: Blood Platelets; Calcium; Carcinogens; Enzyme Activation; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphatidylinositols; Platelet Activating Factor; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Thrombin; Vasopressins	1985

Article

Year

Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets.

FEBS letters, 1985, Jan-28, Volume: 180, Issue:2

Tumour-promoting phorbol esters (phorbol-12-myristate-13-acetate, PMA; phorbol-12,13-dibutyrate, PDBu) but not 4 beta-phorbol, activate protein kinase C. Using human platelets pre-labelled with quin2 or 32PO4 we examined the effects of these compounds on human platelet cytosolic free Ca2+ ([Ca2+]i) and on [32P]phosphatidic acid ([32P]PtdOH). PMA and PDBu, but not 4 beta-phorbol inhibited thrombin-, PAF- and vasopressin-induced elevation of [Ca2+]i and [32P]PtdOH formation. It is suggested that protein kinase C may act to terminate the transduction processes that link receptor occupancy to cellular activation.

Topics: Blood Platelets; Calcium; Carcinogens; Enzyme Activation; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphatidylinositols; Platelet Activating Factor; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Thrombin; Vasopressins

1985