pituitrin has been researched along with perfluorooctanoic-acid* in 1 studies
1 other study(ies) available for pituitrin and perfluorooctanoic-acid
| Article | Year |
|---|---|
Exposure of female mice to perfluorooctanoic acid suppresses hypothalamic kisspeptin-reproductive endocrine system through enhanced hepatic fibroblast growth factor 21 synthesis, leading to ovulation failure and prolonged dioestrus.
Perfluorooctanoic acid (PFOA) is widely used in household applications. High-dose exposure to PFOA has been associated with increased risks of infertility and premature ovarian insufficiency in woman. PFOA can alter hepatic gene expression by activating peroxisome proliferator-activated receptor α (PPARα). The present study investigated whether exposure to PFOA via PPARα activation alters the synthesis of hepatic fibroblast growth factor 21 (FGF21) to disturb female neuroendocrine and reproductive function. In the present study, we show that the oral administration of PFOA (2 or 5 mg kg Topics: Animals; Caprylates; Endocrine System; Female; Fibroblast Growth Factors; Fluorocarbons; Humans; Kisspeptins; Liver; Luteinizing Hormone; Mice; Ovulation; PPAR alpha; Vasopressins | 2020 |