pituitrin and ipragliflozin

pituitrin has been researched along with ipragliflozin* in 1 studies

Other Studies

1 other study(ies) available for pituitrin and ipragliflozin

Article	Year
Osmotic diuresis by SGLT2 inhibition stimulates vasopressin-induced water reabsorption to maintain body fluid volume. Physiological reports, 2020, Volume: 8, Issue:2 Most of the filtered glucose is reabsorbed in the early proximal tubule by the sodium-glucose cotransporter SGLT2. The glycosuric effect of the SGLT2 inhibitor ipragliflozin is linked to a diuretic and natriuretic effect that activates compensatory increases in fluid and food intake to stabilize body fluid volume (BFV). However, the compensatory mechanisms that are activated on the level of renal tubules remain unclear. Type 2 diabetic Goto-Kakizaki (GK) rats were treated with vehicle or 0.01% (in diet) ipragliflozin with free access to fluid and food. After 8 weeks, GK rats were placed in metabolic cages for 24-hr. Ipragliflozin decreased body weight, serum glucose and systolic blood pressure, and increased fluid and food intake, urinary glucose and Na Topics: Animals; Body Fluid Compartments; Body Fluids; Diuresis; Diuretics, Osmotic; Glucosides; Osmosis; Rats; Renal Reabsorption; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Vasopressins; Water	2020

Article

Year

Osmotic diuresis by SGLT2 inhibition stimulates vasopressin-induced water reabsorption to maintain body fluid volume.

Physiological reports, 2020, Volume: 8, Issue:2

Most of the filtered glucose is reabsorbed in the early proximal tubule by the sodium-glucose cotransporter SGLT2. The glycosuric effect of the SGLT2 inhibitor ipragliflozin is linked to a diuretic and natriuretic effect that activates compensatory increases in fluid and food intake to stabilize body fluid volume (BFV). However, the compensatory mechanisms that are activated on the level of renal tubules remain unclear. Type 2 diabetic Goto-Kakizaki (GK) rats were treated with vehicle or 0.01% (in diet) ipragliflozin with free access to fluid and food. After 8 weeks, GK rats were placed in metabolic cages for 24-hr. Ipragliflozin decreased body weight, serum glucose and systolic blood pressure, and increased fluid and food intake, urinary glucose and Na

Topics: Animals; Body Fluid Compartments; Body Fluids; Diuresis; Diuretics, Osmotic; Glucosides; Osmosis; Rats; Renal Reabsorption; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Vasopressins; Water

2020