Compounds > pirodavir
Page last updated: 2024-08-25

pirodavir and piperidines

pirodavir has been researched along with piperidines in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (32.00)18.2507
2000's6 (24.00)29.6817
2010's11 (44.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andries, K; Dewindt, B; Janssen, PA; Snoeks, J; Stokbroekx, R; van Eemeren, K; Willebrords, R1
Andries, K; Hayden, FG; Janssen, PA1
Andries, K; Eisen, GF; Hayden, FG; Hipskind, GJ; Janssen, PA; Janssens, M; Woerner, DH1
Andries, K; Boeyé, A; Rombaut, B; Verheyden, B1
Andries, K; Boeyé, A; Dewindt, B; Rombaut, B1
Andries, K; Boeyé, A; Rombaut, B1
Jore, JP; Rombaut, B1
Minor, PD; Pipkin, PA1
Hayden, FG1
Andries, K; Rombaut, B; Verheyden, B1
Cuconati, A; Rombau, B; Verlinden, Y; Wimmer, E1
Barnard, DL; Brown, RN; Cameron, R; Chalmers, DK; Hamilton, S; Jin, B; Krippner, GY; Luttick, A; McConnell, DB; Reece, PA; Ryan, J; Sidwell, RW; Stanislawski, PC; Tucker, SP; Watson, KG; Wu, WY1
Barnard, DL; Hubbard, VD; Reece, PA; Sidwell, RW; Smee, DF; Tucker, SP; Watson, KG1
Agarwal, N; Arya, SC1
Gong, ZH; Liu, Y; Lu, XQ; Yan, H1
Laconi, S; Madeddu, MA; Pompei, R1
Gao, RM; Hao, LH; He, WY; Ji, XY; Jiang, JD; Li, YH; Li, YP; Li, ZR; Wang, HQ1
Aguayo, E; Birkus, G; Cihlar, T; Jordan, R; Lee, G; Mello, C; Rodriguez, M1
Bernard, AM; Cabiddu, MG; De Montis, S; Mura, R; Pompei, R1
Chaltin, P; De Palma, A; Koukni, M; Leyssen, P; Marchand, A; Martin, J; Neyts, J; Oberste, S; Pürstinger, G; Rhoden, E; Spieser, SA; Thibaut, HJ; Tijsma, A; Volny-Luraghi, A1
Franco, D; Froeyen, M; Hilgenfeld, R; Leyssen, P; Neyts, J; Tijsma, A; Tucker, S1
Bernard, A; Cabiddu, MG; Lacroix, C; Leyssen, P; Neyts, J; Pompei, R1
Angius, F; Coluccia, A; Laconi, S; Lacroix, C; Leyssen, P; Neyts, J; Pompei, R; Silvestri, R1
Day, CW; Evans, WJ; Nicolaou, KC; Smee, DF; Tarbet, EB1
Hu, J; Li, YH; Wang, HQ; Wu, S; Yan, HY1

Reviews

1 review(s) available for pirodavir and piperidines

ArticleYear
Influenza virus and rhinovirus-related otitis media: potential for antiviral intervention.
    Vaccine, 2000, Dec-08, Volume: 19 Suppl 1

    Topics: Acetamides; Adult; Anti-Bacterial Agents; Antiviral Agents; Child; Child, Preschool; Clinical Trials as Topic; Eustachian Tube; Guanidines; Humans; Infant; Influenza A virus; Influenza B virus; Influenza, Human; Interferon-beta; Oseltamivir; Otitis Media; Otitis Media with Effusion; Picornaviridae Infections; Piperidines; Pressure; Pyrans; Pyridazines; Respiratory Tract Infections; Rhinovirus; Rimantadine; Sialic Acids; Superinfection; Virus Replication; Zanamivir

2000

Trials

2 trial(s) available for pirodavir and piperidines

ArticleYear
Safety and efficacy of intranasal pirodavir (R77975) in experimental rhinovirus infection.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:4

    Topics: Administration, Intranasal; Adolescent; Adult; Common Cold; Double-Blind Method; Humans; Middle Aged; Piperidines; Pyridazines

1992
Intranasal pirodavir (R77,975) treatment of rhinovirus colds.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:2

    Topics: Administration, Intranasal; Adolescent; Adult; Aged; Antiviral Agents; Common Cold; Double-Blind Method; Female; Humans; Male; Middle Aged; Patient Compliance; Piperidines; Pyridazines; Rhinovirus

1995

Other Studies

22 other study(ies) available for pirodavir and piperidines

ArticleYear
In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:1

    Topics: Antiviral Agents; Enterovirus; Microbial Sensitivity Tests; Piperidines; Pyridazines; Rhinovirus

1992
Thermal inactivation of oral polio vaccine: contribution of RNA and protein inactivation.
    Journal of virology, 1994, Volume: 68, Issue:10

    Topics: Antiviral Agents; Cell Line; Centrifugation, Density Gradient; Hot Temperature; Humans; Kidney; Methionine; Piperidines; Poliovirus; Poliovirus Vaccine, Oral; Pyridazines; RNA, Viral; Transfection; Uridine; Vaccines, Inactivated; Viral Plaque Assay; Viral Proteins

1994
Discrepancy between infectivity and antigenicity stabilization of oral poliovirus vaccine by a capsid-binding compound.
    Journal of virology, 1994, Volume: 68, Issue:5

    Topics: Antiviral Agents; Drug Stability; HeLa Cells; Humans; Piperidines; Poliovirus; Poliovirus Vaccine, Oral; Pyridazines

1994
Stabilisation of poliovirus with pirodavir.
    Developments in biological standardization, 1996, Volume: 87

    Topics: Antibodies, Viral; Antigens, Viral; Capsid; Cells, Cultured; Cytopathogenic Effect, Viral; Drug Stability; Drug Synergism; Hot Temperature; Magnesium Chloride; Piperidines; Poliovirus; Poliovirus Vaccine, Oral; Preservatives, Pharmaceutical; Protein Binding; Protein Conformation; Protein Denaturation; Pyridazines; RNA, Viral

1996
Immunogenic, non-infectious polio subviral particles synthesized in Saccharomyces cerevisiae.
    The Journal of general virology, 1997, Volume: 78 ( Pt 8)

    Topics: 3C Viral Proteases; Antigens, Viral; Capsid; Chromatography, Affinity; Cloning, Molecular; Cysteine Endopeptidases; Genes, Viral; Piperidines; Poliovirus; Poliovirus Vaccine, Inactivated; Preservatives, Pharmaceutical; Pyridazines; Recombinant Proteins; Saccharomyces cerevisiae; Viral Proteins; Viral Structural Proteins

1997
Studies on the loss of infectivity of live type 3 poliovaccine on storage.
    Biologicals : journal of the International Association of Biological Standardization, 1998, Volume: 26, Issue:1

    Topics: Antiviral Agents; Cells, Cultured; Drug Stability; Drug Storage; Humans; Hydrogen-Ion Concentration; Piperidines; Poliovirus; Poliovirus Vaccine, Oral; Polysorbates; Preservatives, Pharmaceutical; Pyridazines; Surface-Active Agents

1998
Capsid and RNA stabilisation of the oral polio vaccine.
    Vaccine, 2001, Feb-28, Volume: 19, Issue:15-16

    Topics: Capsid; Child; Deuterium Oxide; Drug Stability; Drug Storage; Humans; In Vitro Techniques; Piperidines; Poliovirus; Poliovirus Vaccine, Oral; Preservatives, Pharmaceutical; Protein Denaturation; Pyridazines; RNA Stability; RNA, Viral; Species Specificity; Temperature

2001
The viral protein 3CD induces an equilibrium between the viral protein and RNA synthesis in a cell-free system for poliovirus replication.
    Archives of virology, 2002, Volume: 147, Issue:4

    Topics: 3C Viral Proteases; Animals; Cell-Free System; Cysteine Endopeptidases; HeLa Cells; Humans; Piperidines; Poliovirus; Pyridazines; Reticulocytes; RNA, Viral; Time Factors; Viral Proteins; Virus Replication

2002
An orally bioavailable oxime ether capsid binder with potent activity against human rhinovirus.
    Journal of medicinal chemistry, 2003, Jul-17, Volume: 46, Issue:15

    Topics: Administration, Oral; Animals; Antiviral Agents; Biological Availability; Capsid; Cell Line; Ethers; Female; Humans; Male; Mice; Oximes; Piperidines; Protein Binding; Pyridazines; Rats; Rhinovirus; Structure-Activity Relationship

2003
In vitro activity of expanded-spectrum pyridazinyl oxime ethers related to pirodavir: novel capsid-binding inhibitors with potent antipicornavirus activity.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:5

    Topics: Animals; Antiviral Agents; Biological Availability; Capsid; Cell Line; Cytopathogenic Effect, Viral; Enterovirus; Enterovirus B, Human; Haplorhini; Humans; KB Cells; Neutral Red; Oximes; Picornaviridae; Piperidines; Pyridazines; Rhinovirus; Virus Replication

2004
Stability of smallpox vaccine in field conditions.
    Vaccine, 2006, Feb-27, Volume: 24, Issue:9

    Topics: Deuterium Oxide; Drug Stability; Excipients; Humans; Piperidines; Pyridazines; Smallpox Vaccine

2006
[Establishment of isolated rabbit airway smooth muscles responsiveness model for the pharmacodynamic study of anti-rhinoviruses drugs].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:4

    Topics: Acetylcholine; Animals; Antiviral Agents; Cytopathogenic Effect, Viral; HeLa Cells; Humans; Isoproterenol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Piperidines; Pyridazines; Rabbits; Rhinovirus; Trachea

2010
Study of the biological activity of novel synthetic compounds with antiviral properties against human rhinoviruses.
    Molecules (Basel, Switzerland), 2011, Apr-26, Volume: 16, Issue:5

    Topics: Antiviral Agents; Cell Line, Tumor; Cell Survival; HeLa Cells; Humans; Piperidines; Pyridazines; Rhinovirus

2011
Synthesis and antiviral activity of N-phenylbenzamide derivatives, a novel class of enterovirus 71 inhibitors.
    Molecules (Basel, Switzerland), 2013, Mar-21, Volume: 18, Issue:3

    Topics: Animals; Antiviral Agents; Benzamides; Chlorocebus aethiops; Drug Evaluation, Preclinical; Enterovirus; Inhibitory Concentration 50; Piperidines; Pyridazines; Structure-Activity Relationship; Vero Cells

2013
Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:3

    Topics: Antiviral Agents; Common Cold; Dose-Response Relationship, Drug; HeLa Cells; Humans; In Vitro Techniques; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Piperidines; Pyridazines; Pyrrolidinones; Replicon; Rhinovirus; RNA, Viral; Tubercidin; Valine; Virus Replication

2014
Synthesis of new compounds with promising antiviral properties against group A and B Human Rhinoviruses.
    Bioorganic & medicinal chemistry, 2014, Aug-01, Volume: 22, Issue:15

    Topics: Antiviral Agents; Benzoic Acid; Benzoxazoles; Cell Survival; Drug Design; HeLa Cells; Humans; Piperidines; Pyridazines; Rhinovirus; Serotyping; Structure-Activity Relationship

2014
H1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1.
    Antiviral research, 2014, Volume: 110

    Topics: Amino Acid Substitution; Animals; Antiviral Agents; Base Sequence; Binding Sites; Capsid; Capsid Proteins; Cell Line, Tumor; Chlorocebus aethiops; Drug Resistance, Viral; HeLa Cells; Humans; Models, Molecular; Piperidines; Poliomyelitis; Poliovirus; Pyrazoles; Pyridazines; Pyrimidines; RNA, Viral; Sequence Analysis, RNA; Virus Replication

2014
The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:11

    Topics: Antiviral Agents; Benzimidazoles; Capsid; Capsid Proteins; Drug Resistance, Viral; Enterovirus A, Human; Enterovirus Infections; Isoxazoles; Molecular Docking Simulation; Oximes; Phenylalanine; Piperidines; Protease Inhibitors; Protein Binding; Pyridazines; Pyrrolidinones; Sulfonamides; Valine; Virus Replication

2014
Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds.
    Antiviral chemistry & chemotherapy, 2015, Volume: 24, Issue:2

    Topics: Antiviral Agents; Dose-Response Relationship, Drug; Enterovirus; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Piperidines; Pyridazines; Structure-Activity Relationship

2015
In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses.
    Virology journal, 2015, Jul-14, Volume: 12

    Topics: Antiviral Agents; Capsid Proteins; Humans; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Piperidines; Protein Binding; Pyridazines; Rhinovirus

2015
Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds.
    Antiviral research, 2016, Volume: 131

    Topics: A549 Cells; Antimetabolites; Antiviral Agents; Benzimidazoles; Enterovirus A, Human; Enterovirus D, Human; Guanine; HeLa Cells; Humans; Oxadiazoles; Oxazoles; Oximes; Picornaviridae; Piperazines; Piperidines; Pyridazines; Rhabdomyosarcoma; Rhinovirus; Ribavirin; Sulfonamides

2016
Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression.
    Journal of Asian natural products research, 2017, Volume: 19, Issue:11

    Topics: Antiviral Agents; Berberine Alkaloids; Cyclooxygenase 2 Inhibitors; Enterovirus A, Human; Humans; JNK Mitogen-Activated Protein Kinases; Molecular Structure; p38 Mitogen-Activated Protein Kinases; Piperidines; Pyridazines; Signal Transduction; Virus Replication

2017