Page last updated: 2024-08-24

pirmenol and piperidines

pirmenol has been researched along with piperidines in 93 studies

Research

Studies (93)

Timeframe	Studies, this research(%)	All Research%
pre-1990	56 (60.22)	18.7374
1990's	32 (34.41)	18.2507
2000's	5 (5.38)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Kato, R; Koide, M; Miyahara, T; Sotobata, I; Toyama, J; Ukai, M; Yasui, S; Yokota, M	1
Kanno, M; Nakaya, H; Oyama, Y; Shishido, Y	1
Ciaravino, V; Krishna, G; Kropko, ML; Monteith, DK; Theiss, JC	1
Endou, M; Gando, S; Hattori, Y; Kanno, M	2
Beasley, M; Bland, R; Campbell, AJ; Edwards, IR; Ferry, DG; Gazeley, L	1
Endou, M; Gandou, S; Hattori, Y; Kanno, M; Nakaya, H	1
Sugimoto, T; Yamashita, T	1
Adaniya, H; Hayami, H; Hiraoka, M; Kawano, S; Kuga, K; Sawanobori, T; Yamashita, K	1
Akimoto, H; Aonuma, K; Chung, YH; Hiraoka, M; Iesaka, Y; Marumo, F; Nitta, J; Nogami, A; Takahashi, A	1
Bockbrader, HN; Cetnarowski-Cropp, AB; Chang, T; Goldfarb, AL; Lebsack, ME; Radulovic, LL; Sedman, AJ; Stringer, KA	1
Hashimoto, H; Nagashima, S; Nakashima, M; Ozaki, T	1
Amidon, GL; Bockbrader, HN; Chang, T; Janiczek, N; Smith, DE	1
Hoyer, GL	1
Abadier, R; Chrymko, M; Lebsack, ME; Sedman, A; Stringer, KA; Switzer, DF	1
Endou, M	1
Blouin, LT; Fleming, RW; Hastings, S; Hinkley, JM; Hoefle, ML; Mertz, TE; Steffe, TJ; Stratton, CS	1
Farmer, C; Fifield, J; Hodges, M; Salerno, DM	1
Hauswirth, O; Konzen, G; Reichardt, B	1
Hashimoto, K; Motomura, S; Sugiyama, A; Tamura, K	1
Hasegawa, J; Hirai, S; Hisatome, I; Kotake, H; Mashiba, H; Noguchi, N	1
Frick, MH; Manninen, V; Nieminen, MS; Toivonen, LK	3
Canada, AT; Johnson, BF; Shekar, V; Woodman, T	1
Baerman, J; Crevey, B; de Buitleir, M; Johnson, T; Morady, F	1
Chang, T	1
Farnham, DJ	1
Báguena Candela, J	1
Frumin, H; Gold, RL; Haffajee, CI; Jarandilla, R; Kerin, NZ	1
Crevey, BJ; de Buitleir, M; Johnson, T; Kou, WH; Morady, F; Nelson, SD; Schmaltz, S	1
Garg, DC; Jallad, NS; Ng, KF; Singh, S; Weidler, DJ	1
Kates, RE; Liem, LB	1
Somberg, J	1
Frick, H; Manninen, V; Nieminen, MS; Toivonen, LK	2
Hashimoto, K; Sugiyama, A; Watanabe, K	1
Hasegawa, J; Hirai, S; Ito, T; Kinugawa, T; Kotake, H; Mashiba, H; Yamasaki, J	1
Cetnarowski, AB; Chang, T; Goldfarb, A; Lebsack, ME; Sedman, AJ; Stringer, KA	1
Kanno, M; Nakaya, H; Tohse, N	1
Kaplan, HR; Mertz, TE; Steffe, TJ	2
Reiter, MJ	1
Frick, H; Manninen, V; Nieminen, MS; Toivonen, L	1
de la Iglesia, FA; Martin, RA	2
Morris, KG; Phillips, HR	1
Haffajee, CI; Johnson, BF; Sloan, KL; Woodman, T	1
Toivonen, LK	2
Clay, DA; Franz, MR; Liem, LB; Swerdlow, CD	1
Cameron, J; Estes, NA; Gold, R; Haffajee, C; Mack, K; Marshall, M; Salem, DN	1
Algarra Vidal, FJ; Gimeno Gascon, JV	1
Keefe, D; Laux, B; Miura, DS; Schwartz, J; Somberg, JC; Wynn, J	1
Ellenbogen, KA; Kates, RE; McCarthy, EA; Pritchett, EL; Roark, SF; Sintetos, AL; Smith, MS; Smith, WM	1
Easley, AR; Luck, JC; Magro, SA; Mann, DE; Reiter, MJ; Sakun, V; Sullivan, SM; Wyndham, CR	1
Anderson, JA; de la Iglesia, F; Fitzgerald, JE; Petrere, JA	1
DiCarlo, LA; Hassan, T; Lucchesi, BR; Lynch, JJ; Montgomery, DG	1
Anderson, JL; Hampton, EM; Lutz, JR; Nappi, JM	1
Nieminen, MS; Toivonen, LK	1
Brown, JE; Klein, GJ; Yee, R	1
Somberg, JC	1
Anderson, JL; Lutz, JR; Nappi, JM	1
Johnson, EL; Pachla, LA	1
Pritchett, EL; Reiter, MJ	1
Hammill, SC; McCarthy, E; Pritchett, EL; Reiter, MJ; Shand, DG; Verghese, C	1
Hammill, SC; Pritchett, EL; Shand, DG; Stargel, WW; Wagner, GS	1
Baker, JT; Hammill, SC; Hindman, MC; Pritchett, EL; Routledge, PA; Shand, DG	1
Davis, DD; Lee, KL; Morris, KG; Phillips, HR; Pritchett, EL; Shand, DG; Stack, RS	1
Kaplan, HR; Mertz, TE	1
Hammill, SC; Harrell, FE; Pritchett, EL; Reiter, MJ; Shand, DG; Verghese, C; Zimmerman, JM	1
Danilo, P; Reder, RF; Rosen, MR	1
Hastings, SG; Kaplan, HR; Mertz, TE; Potoczak, RE; Steffe, TJ	1
de la Iglesia, FA; Fitzgerald, JE; McGuire, EJ; Sanyer, JL; Schardein, JL	1
Bjornsson, TD; Desjardins, RE; Hammill, SC; Pritchett, EL; Shand, DG	1
Lee, JH; Rosen, MR	1
Harasawa, K; Ichikawa, S; Ishii, T; Minohara, K; Nishiyama, S; Sakano, I; Yamamura, S	1
Atarashi, H; Hayakawa, H; Hirayama, Y; Ino, T; Kuruma, A; Saitoh, H	1
Chang, T; Janiczek, N; Mertz, TE; Smith, DE; Ventura, A	1
Chang, T; Janiczek, N; Sedman, AJ; Smith, DE; Stringer, KA	1
Hara, Y; Nakaya, H; Tamagawa, M; Watanabe, Y	1
Abe, M; Iida, S; Kaneko, K; Kitashima, M; Matsuki, Y; Nakagomi, M; Suzuki, E	1
Hazama, H; Iwasawa, K; Nakajima, T; Omata, M	1
Abe, H; Hanada, H; Kohshi, K; Nakashima, Y; Numata, T	1
Hiraoka, M; Inoue, H; Kasanuki, H; Kato, T; Kodama, I; Mitamura, H; Ogawa, S; Sugimoto, T	1
Kasai, H; Kusumoto, M; Shibakawa, M; Ueno, K	1
Katoh, T; Ono, T; Sutovsky, I; Takano, T; Takayama, H	1
Akasaka, T; Kaji, S; Kamiyama, N; Koyama, Y; Saito, Y; Suetsuna, R; Yoshida, K	1
Asano, J; Kobayashi, M; Kohya, T; Kojima, M; Miyamoto, N; Ooe, T; Saitoh, H; Sekizawa, Y; Suzuki, Y	1
Emi, S; Ishimoto, T; Kageyama, N; Mizuguchi, Y; Nagase, N; Oishi, Y; Oki, T	1
Hara, M; Nakagawa, M; Ooie, T; Saikawa, T; Takahashi, N; Yoshimatsu, H	1

Reviews

6 review(s) available for pirmenol and piperidines

Article	Year
Update: cardiac antiarrhythmic drugs. Comprehensive therapy, 1989, Volume: 15, Issue:4 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Encainide; Flecainide; Humans; Mexiletine; Piperidines; Propafenone; Propanolamines	1989
Antiarrhythmic drug therapy. Recent advances and current status. Cardiology, 1985, Volume: 72, Issue:5-6 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil	1985
Pirmenol: preclinical pharmacology. Angiology, 1988, Volume: 39, Issue:3 Pt 2 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Drug Evaluation, Preclinical; Drug Interactions; Electrophysiology; Heart; Piperidines	1988
Clinical pharmacology and pharmacokinetics of pirmenol. Angiology, 1988, Volume: 39, Issue:3 Pt 2 Topics: Administration, Oral; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Evaluation; Half-Life; Humans; Injections, Intravenous; Piperidines	1988
Pharmacokinetic studies: their role in determining therapeutic efficacy of agents designed to prevent sudden death. Annals of the New York Academy of Sciences, 1982, Volume: 382 Topics: Administration, Oral; Anti-Arrhythmia Agents; Coronary Disease; Death, Sudden; Dose-Response Relationship, Drug; Humans; Infusions, Parenteral; Kinetics; Lidocaine; Myocardial Infarction; Piperidines; Propranolol	1982
Profiles of aprindine, cibenzoline, pilsicainide and pirmenol in the framework of the Sicilian Gambit. The Guideline Committee for Clinical Use of Antiarrhythmic Drugs in Japan (Working Group of Arrhythmias of the Japanese Society of Electrocardiology). Japanese circulation journal, 1999, Volume: 63, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Humans; Imidazoles; Lidocaine; Piperidines	1999

Trials

14 trial(s) available for pirmenol and piperidines

Article	Year
Pirmenol: an antiarrhythmic drug with unique electrocardiographic features--a double-blind placebo-controlled comparison with quinidine. Clinical cardiology, 1991, Volume: 14, Issue:1 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Double-Blind Method; Electrocardiography; Female; Humans; Male; Middle Aged; Piperidines; Quinidine; Stroke Volume	1991
Antiarrhythmic efficacy of pirmenol in the treatment of premature ventricular complexes. European heart journal, 1985, Volume: 6, Issue:9 Topics: Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Electrocardiography; Female; Humans; Kinetics; Male; Myocarditis; Piperidines; Tachycardia	1985
Efficacy of oral pirmenol in suppressing ventricular premature depolarisations. Irish medical journal, 1987, Volume: 80, Issue:2 Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Humans; Male; Middle Aged; Piperidines; Random Allocation	1987
A multicenter dose-response study of pirmenol hydrochloride in patients with ventricular premature contractions. The American journal of cardiology, 1987, Jun-15, Volume: 59, Issue:16 Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Ventricles; Humans; Male; Middle Aged; Piperidines; Placebos	1987
Effectiveness of pirmenol hydrochloride in suppressing high frequency ventricular ectopy: a placebo-controlled, double-blind, multicenter study. The American journal of cardiology, 1987, Jun-15, Volume: 59, Issue:16 Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Clinical Trials as Topic; Double-Blind Method; Female; Heart Ventricles; Humans; Male; Middle Aged; Piperidines; Placebos	1987
Long-term efficacy of oral pirmenol in suppressing ventricular premature depolarizations. American heart journal, 1988, Volume: 116, Issue:2 Pt 1 Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Female; Heart Ventricles; Humans; Male; Middle Aged; Piperidines; Random Allocation; Time Factors	1988
Efficacy and pharmacokinetics of oral pirmenol, a new antiarrhythmic drug. Journal of clinical pharmacology, 1988, Volume: 28, Issue:9 Topics: Administration, Oral; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Complexes, Premature; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Double-Blind Method; Female; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Piperidines; Random Allocation	1988
Conversion of paroxysmal atrial fibrillation to sinus rhythm by intravenous pirmenol. The American journal of cardiology, 1987, Jun-15, Volume: 59, Issue:16 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Atrial Fibrillation; Humans; Injections, Intravenous; Piperidines; Placebos; Random Allocation	1987
Hemodynamic effects of pirmenol and lidocaine: a placebo-controlled, double-blind, comparative study. The American journal of cardiology, 1987, Jun-15, Volume: 59, Issue:16 Topics: Adult; Anti-Arrhythmia Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Echocardiography; Heart Atria; Heart Rate; Heart Ventricles; Hemodynamics; Humans; Lidocaine; Middle Aged; Piperidines; Placebos; Stroke Volume	1987
Conversion of paroxysmal atrial fibrillation to sinus rhythm by intravenous pirmenol. A placebo controlled study. British heart journal, 1986, Volume: 55, Issue:2 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Heart Rate; Humans; Middle Aged; Piperidines	1986
Acute haemodynamic effects of the antiarrhythmic agent pirmenol in cardiac patients: a comparison with lidocaine. European heart journal, 1986, Volume: 7, Issue:2 Topics: Adult; Analysis of Variance; Anti-Arrhythmia Agents; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Female; Hemodynamics; Humans; Lidocaine; Male; Middle Aged; Myocardial Infarction; Piperidines	1986
Effect of pirmenol on premature atrial complexes. Annals of clinical research, 1986, Volume: 18, Issue:2 Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Heart Atria; Humans; Injections, Intravenous; Middle Aged; Piperidines	1986
Efficacy, safety, and pharmacokinetics of a concentration-maintaining regimen of intravenous pirmenol. The American journal of cardiology, 1983, Volume: 52, Issue:1 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Double-Blind Method; Drug Evaluation; Electrocardiography; Female; Heart Rate; Humans; Infusions, Parenteral; Kinetics; Male; Middle Aged; Monitoring, Physiologic; Piperidines; Random Allocation	1983
Clinical effects and pharmacokinetics of a single oral dose of pirmenol hydrochloride. Journal of cardiovascular pharmacology, 1996, Volume: 27, Issue:4 Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Atrial Fibrillation; Female; Hemodynamics; Humans; Male; Middle Aged; Piperidines; Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Supraventricular	1996

Other Studies

73 other study(ies) available for pirmenol and piperidines

Article	Year
[Pharmacokinetics and pharmacodynamics of class I antiarrhythmic agents after a single oral administration]. Japanese circulation journal, 1992, Volume: 56 Suppl 5 Topics: Administration, Oral; Anti-Arrhythmia Agents; Aprindine; Flecainide; Humans; Imidazoles; Lidocaine; Mexiletine; Piperidines; Propafenone	1992
Voltage-dependent modification of Vmax recovery from use-dependent block by pirmenol in guinea pig papillary muscles: comparison with other class I drugs. Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Mexiletine; Microelectrodes; Neuromuscular Depolarizing Agents; Papillary Muscles; Piperidines; Propylamines; Pyridines; Quinidine; Sodium Channels	1992
Genotoxicity assessment of pirmenol, a new antiarrhythmic drug. Mutation research, 1992, Volume: 280, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Biotransformation; Bone Marrow; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Escherichia coli; Male; Mice; Mice, Inbred ICR; Micronucleus Tests; Mutagenicity Tests; Mutagens; Piperidines; Salmonella typhimurium; Sister Chromatid Exchange	1992
Selectivity of class I antiarrhythmic agents, disopyramide, pirmenol, and pentisomide for peripheral muscarinic M2 and M3 receptors. Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Binding, Competitive; Disopyramide; Female; Guinea Pigs; Kinetics; Male; Muscle, Smooth; N-Methylscopolamine; Piperidines; Propylamines; Pyridines; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland; Urinary Bladder	1992
Pharmacokinetics of pirmenol in young and elderly subjects. European journal of clinical pharmacology, 1992, Volume: 43, Issue:4 Topics: Adult; Aged; Aging; Anti-Arrhythmia Agents; Drug Administration Schedule; Female; Humans; Male; Piperidines	1992
Electrophysiologic and anticholinergic effects of pirmenol enantiomers in guinea-pig myocardium. Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 346, Issue:5 Topics: Action Potentials; Animals; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Membrane Potentials; Membranes; Myocardium; N-Methylscopolamine; Papillary Muscles; Parasympatholytics; Piperidines; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives; Stereoisomerism	1992
[Medical management of arrhythmias; newer antiarrhythmic drugs]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:11 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Chlorobenzenes; Flecainide; Humans; Membrane Potentials; Moricizine; Piperidines; Propylamines; Pyridines; Sodium Channels	1991
Electrophysiologic and antiarrhythmic actions of pirmenol on rabbit and guinea pig cardiac preparations. Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:6 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Microelectrodes; Myocardium; Papillary Muscles; Piperidines; Potassium Chloride; Purkinje Fibers; Rabbits; Sinoatrial Node; Species Specificity	1990
Effects of pirmenol on electrical induction of sustained ventricular tachycardia in a seven-day-old canine myocardial infarction. Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Dogs; Electric Stimulation; Electrocardiography; Electrophysiology; Heart Ventricles; Myocardial Infarction; Piperidines; Tachycardia; Ventricular Function	1991
Effect of cimetidine administration on the pharmacokinetics of pirmenol. Journal of clinical pharmacology, 1992, Volume: 32, Issue:1 Topics: Administration, Oral; Adult; Cimetidine; Drug Administration Schedule; Drug Interactions; Female; Humans; Male; Piperidines	1992
Comparison of the effects of pirmenol and lidocaine on intraventricular conduction in canine myocardial infarction. Journal of electrocardiology, 1991, Volume: 24, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Bundle of His; Dogs; Electric Conductivity; Electrocardiography; Heart Conduction System; Lidocaine; Myocardial Infarction; Piperidines	1991
Stereoselective high-performance liquid chromatographic assay for pirmenol enantiomers in dog plasma. Journal of chromatography, 1991, Nov-15, Volume: 571, Issue:1-2 Topics: Animals; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Dogs; Hexanes; Hydrochloric Acid; Male; Piperidines; Stereoisomerism; Toluene	1991
Pirmenol determination by high-performance liquid chromatography. Journal of chromatography, 1991, Apr-19, Volume: 565, Issue:1-2 Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Piperidines	1991
Binding profiles of class I antiarrhythmic agents to cardiac muscarinic receptors: competitive and allosteric interactions with the receptors and their pharmacological significance. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Binding, Competitive; Depression, Chemical; Disopyramide; Female; Guinea Pigs; Heart; Heart Atria; Kinetics; Male; Membranes; Myocardial Contraction; Myocardium; Piperidines; Propylamines; Pyridines; Receptors, Muscarinic	1991
The effect of pirmenol administration on the anti-coagulant activity of warfarin. Journal of clinical pharmacology, 1991, Volume: 31, Issue:7 Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Drug Interactions; Humans; Middle Aged; Piperidines; Prothrombin Time; Thromboembolism; Warfarin	1991
[Pharmacological analysis of drug interactions of disopyramide and its congeners with peripheral muscarinic acetylcholine receptors]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1991, Volume: 66, Issue:5 Topics: Animals; Binding, Competitive; Carbachol; Disopyramide; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Myocardial Contraction; N-Methylscopolamine; Piperidines; Propylamines; Pyridines; Receptors, Muscarinic; Scopolamine Derivatives	1991
Synthesis and antiarrhythmic activity of cis-2,6-dimethyl-alpha,alpha-diaryl-1-piperidinebutanols. Journal of medicinal chemistry, 1991, Volume: 34, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Benzyl Compounds; Coronary Vessels; Dogs; Heart Rate; Indicators and Reagents; Molecular Structure; Piperidines; Structure-Activity Relationship	1991
Pirmenol, a new antiarrhythmic drug with potassium- and sodium-channel blocking activity; a voltage-clamp study in rabbit Purkinje fibres. Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 341, Issue:5 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Computer Simulation; Dose-Response Relationship, Drug; Female; Male; Membrane Potentials; Models, Biological; Papillary Muscles; Piperidines; Potassium Channels; Purkinje Fibers; Rabbits; Sodium; Sodium Channels; Time Factors	1990
Comparison of cardiovascular effects of pirmenol with those of disopyramide in isolated canine heart preparations cross-circulated with a donor dog. Japanese journal of pharmacology, 1990, Volume: 53, Issue:1 Topics: Action Potentials; Animals; Atrioventricular Node; Coronary Circulation; Cross Circulation; Disopyramide; Dogs; Female; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Piperidines; Sinoatrial Node	1990
Use-dependent effects of pirmenol on Vmax and conduction in guinea-pig ventricular myocardium. British journal of pharmacology, 1990, Volume: 99, Issue:4 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart Conduction System; Heart Ventricles; In Vitro Techniques; Kinetics; Membrane Potentials; Microelectrodes; Papillary Muscles; Piperidines	1990
Salivary concentrations of pirmenol as a possible cause of unpleasant taste. British journal of clinical pharmacology, 1986, Volume: 22, Issue:5 Topics: Adult; Aged; Biological Transport; Cardiac Complexes, Premature; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperidines; Random Allocation; Saliva; Taste	1986
Preclinical and clinical pharmacokinetics of pirmenol. The American journal of cardiology, 1987, Jun-15, Volume: 59, Issue:16 Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Dogs; Half-Life; Humans; Infusions, Intravenous; Kinetics; Macaca mulatta; Male; Metabolic Clearance Rate; Piperidines; Tissue Distribution	1987
The efficacy, electrophysiologic and electrocardiographic effects of intravenous pirmenol, a new class I antiarrhythmic agent, in patients with ventricular tachycardia: comparison with procainamide. Pacing and clinical electrophysiology : PACE, 1988, Volume: 11, Issue:3 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Electric Stimulation; Electrocardiography; Female; Heart Conduction System; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Piperidines; Procainamide; Recurrence; Tachycardia	1988
Antiarrhythmic plasma concentrations of pirmenol on canine ventricular arrhythmias. Japanese journal of pharmacology, 1988, Volume: 48, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Digitalis; Dogs; Epinephrine; Female; Ligation; Male; Piperidines; Plants, Medicinal; Plants, Toxic	1988
Effects of pirmenol hydrochloride on the spontaneous action potentials and membrane current systems of rabbit sinoatrial node cells. Journal of electrocardiology, 1988, Volume: 21, Issue:4 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Female; Male; Membrane Potentials; Piperidines; Rabbits; Sinoatrial Node	1988
Enhanced pirmenol elimination by rifampin. Journal of clinical pharmacology, 1988, Volume: 28, Issue:12 Topics: Adult; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Drug Interactions; Female; Humans; Male; Piperidines; Rifampin	1988
Frequency- and voltage-dependent depression of maximum upstroke velocity of action potentials by pirmenol in guinea pig ventricular muscles. Japanese journal of pharmacology, 1988, Volume: 48, Issue:4 Topics: Action Potentials; Animals; Disopyramide; Guinea Pigs; Heart; Heart Ventricles; In Vitro Techniques; Piperidines	1988
Pirmenol--a new anti-arrhythmic agent--a clinical overview. International colloquium. Angiology, 1988, Volume: 39, Issue:3 Pt 2 Topics: Animals; Anti-Arrhythmia Agents; Humans; Piperidines	1988
Preclinical toxicology of pirmenol hydrochloride. Angiology, 1988, Volume: 39, Issue:3 Pt 2 Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Body Weight; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart; Injections, Intravenous; Mice; Piperidines; Rabbits; Rats; Reproduction; Time Factors	1988
Hemodynamic effects of intravenous pirmenol. Angiology, 1988, Volume: 39, Issue:3 Pt 2 Topics: Adult; Angina Pectoris; Anti-Arrhythmia Agents; Coronary Disease; Depression, Chemical; Drug Evaluation; Female; Heart Ventricles; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Piperidines; Stroke Volume; Time Factors	1988
The relation of the kinetics of pirmenol to its antiarrhythmic efficacy. Journal of clinical pharmacology, 1988, Volume: 28, Issue:5 Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Half-Life; Humans; Male; Middle Aged; Piperidines	1988
Electrophysiology and antiarrhythmic efficacy of intravenous pirmenol in patients with sustained ventricular tachyarrhythmias. American heart journal, 1987, Volume: 113, Issue:6 Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrioventricular Node; Electrophysiology; Female; Heart Conduction System; Heart Ventricles; Humans; Infusions, Intravenous; Male; Middle Aged; Piperidines; Refractory Period, Electrophysiological; Sinoatrial Node; Tachycardia	1987
A symposium: Pirmenol--a unique, new antiarrhythmic agent. December 2, 1985, Freiburg, Germany. Proceedings. The American journal of cardiology, 1987, Jun-15, Volume: 59, Issue:16 Topics: Animals; Anti-Arrhythmia Agents; Humans; Piperidines	1987
Preclinical toxicology of pirmenol hydrochloride. The American journal of cardiology, 1987, Jun-15, Volume: 59, Issue:16 Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Dogs; Female; Fetus; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Piperidines; Pregnancy; Pregnancy, Animal; Rabbits; Rats; Rats, Inbred Strains; Reproduction; Species Specificity; Xerostomia	1987
Preclinical pharmacology of pirmenol. The American journal of cardiology, 1987, Jun-15, Volume: 59, Issue:16 Topics: Animals; Anti-Arrhythmia Agents; Dogs; Guinea Pigs; Infusions, Intravenous; Piperidines; Potassium; Purkinje Fibers; Stroke Volume	1987
Electrocardiographic and electrophysiologic effects of pirmenol in ventricular tachycardia. The American journal of cardiology, 1987, Jun-15, Volume: 59, Issue:16 Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Electrocardiography; Electrophysiology; Female; Heart Ventricles; Humans; Injections, Intravenous; Male; Middle Aged; Piperidines; Tachycardia; Vasoconstriction	1987
Pirmenol in the termination of paroxysmal supraventricular tachycardia. The American journal of cardiology, 1987, Jun-15, Volume: 59, Issue:16 Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Heart Conduction System; Humans; Middle Aged; Piperidines; Tachycardia, Supraventricular	1987
Preliminary study of pirmenol in the treatment of ventricular arrhythmias. The American journal of cardiology, 1987, Jun-15, Volume: 59, Issue:16 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Double-Blind Method; Female; Heart Diseases; Heart Ventricles; Humans; Male; Middle Aged; Piperidines	1987
Comparative efficacy of pirmenol and procainamide in a drug-resistant population with ventricular tachycardia. Journal of clinical pharmacology, 1987, Volume: 27, Issue:7 Topics: Anti-Arrhythmia Agents; Drug Resistance; Electrocardiography; Electrophysiology; Female; Heart Conduction System; Humans; Male; Middle Aged; Piperidines; Procainamide; Refractory Period, Electrophysiological; Tachycardia	1987
Pharmacodynamics and pharmacokinetics of oral pirmenol. Clinical pharmacology and therapeutics, 1987, Volume: 42, Issue:4 Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Monitoring, Physiologic; Piperidines; Time Factors	1987
Electrophysiologic evaluation of pirmenol for sustained ventricular tachycardia secondary to coronary artery disease. The American journal of cardiology, 1986, Jul-01, Volume: 58, Issue:1 Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Coronary Disease; Heart Conduction System; Humans; Male; Middle Aged; Piperidines; Tachycardia	1986
Pirmenol in termination of paroxysmal supraventricular tachycardia. Clinical cardiology, 1986, Volume: 9, Issue:8 Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Atrioventricular Node; Blood Pressure; Drug Evaluation; Electrocardiography; Humans; Middle Aged; Piperidines; Refractory Period, Electrophysiological; Tachycardia, Paroxysmal	1986
Studies on reproduction in rats with pirmenol, an antiarrhythmic agent. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1986, Volume: 7, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Embryonic and Fetal Development; Female; Fertility; Male; Piperidines; Pregnancy; Rats; Reproduction	1986
Electrophysiologic actions of pirmenol in dogs with recent myocardial infarction. American heart journal, 1986, Volume: 112, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Dogs; Electrophysiology; Heart; Heart Conduction System; Male; Myocardial Infarction; Piperidines; Tachycardia	1986
Initial and long-term outpatient experience with pirmenol for control of ventricular arrhythmias. European journal of clinical pharmacology, 1986, Volume: 31, Issue:1 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Heart Ventricles; Hemodynamics; Humans; Male; Middle Aged; Outpatients; Piperidines; Time Factors	1986
Hemodynamic effects of pirmenol, a new antiarrhythmic agent, assessed noninvasively. International journal of cardiology, 1986, Volume: 10, Issue:2 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Echocardiography; Female; Heart Rate; Hemodynamics; Humans; Infusions, Parenteral; Male; Middle Aged; Piperidines	1986
Acute electrophysiologic effects of pirmenol in normal subjects and in patients with Wolff-Parkinson-White syndrome. The American journal of cardiology, 1986, Apr-01, Volume: 57, Issue:10 Topics: Adult; Anti-Arrhythmia Agents; Atrioventricular Node; Female; Humans; Male; Middle Aged; Piperidines; Reference Values; Sinoatrial Node; Tachycardia; Wolff-Parkinson-White Syndrome	1986
New directions in antiarrhythmic drug therapy. The American journal of cardiology, 1984, Aug-13, Volume: 54, Issue:4 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil	1984
Pirmenol for control of ventricular arrhythmias: oral dose-ranging and short-term maintenance study. The American journal of cardiology, 1984, Feb-01, Volume: 53, Issue:4 Topics: Administration, Oral; Adult; Aged; Ambulatory Care; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Double-Blind Method; Echocardiography; Electrocardiography; Female; Half-Life; Humans; Male; Middle Aged; Piperidines; Stroke Volume; Time Factors	1984
Improved liquid chromatographic assay for the analysis of pirmenol in plasma and urine. Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:6 Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Humans; Kinetics; Piperidines; Time Factors	1984
Investigational antiarrhythmic agents: pirmenol. Clinical cardiology, 1984, Volume: 7, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Heart Rate; Humans; Kinetics; Piperidines	1984
Pirmenol, a new antiarrhythmic agent: initial study of efficacy, safety and pharmacokinetics. Circulation, 1982, Volume: 65, Issue:2 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Female; Half-Life; Heart; Humans; Kinetics; Male; Middle Aged; Piperidines	1982
Hemodynamic effects of the antiarrhythmic drug pirmenol. Clinical pharmacology and therapeutics, 1982, Volume: 32, Issue:2 Topics: Anti-Arrhythmia Agents; Drug Evaluation; Hemodynamics; Humans; Injections, Intravenous; Male; Middle Aged; Piperidines	1982
Pirmenol hydrochloride (CI-845) and reference antiarrhythmic agents: effects on early ventricular arrhythmias after acute coronary artery ligation in anesthetized rats. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 223, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Electric Stimulation; Heart Conduction System; Heart Ventricles; Male; Piperidines; Rats; Rats, Inbred Strains; Vagus Nerve	1982
Pirmenol kinetics and effective oral dose. Clinical pharmacology and therapeutics, 1982, Volume: 32, Issue:6 Topics: Administration, Oral; Blood Pressure; Cardiovascular Diseases; Dose-Response Relationship, Drug; Double-Blind Method; Heart Rate; Humans; Kinetics; Male; Middle Aged; Piperidines; Time Factors	1982
Effects of pirmenol HCl on electrophysiologic properties of cardiac Purkinje fibers. European journal of pharmacology, 1980, Volume: 61, Issue:4 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Blood Pressure; Dogs; Electrocardiography; Heart Conduction System; Membrane Potentials; Neural Conduction; Piperidines; Purkinje Fibers; Time Factors	1980
CL-845 (pirmenol hydrochloride): a new orally effective long-acting antiarrhythmic agent. The Journal of pharmacology and experimental therapeutics, 1980, Volume: 214, Issue:1 Topics: Aconitine; Action Potentials; Administration, Oral; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Epinephrine; Female; Heart Conduction System; Hemodynamics; Male; Ouabain; Piperidines; Time Factors; Ventricular Fibrillation	1980
Preclinical toxicology studies with a new antiarrhythmic agent: pirmenol hydrochloride (CI-845). Toxicology and applied pharmacology, 1980, Volume: 56, Issue:2 Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Dogs; Drug Evaluation, Preclinical; Female; Fetus; Injections, Intravenous; Male; Mice; Piperidines; Pregnancy; Rabbits; Rats; Time Factors	1980
The method of separate exponentials: a simple aid to devising intravenous drug-loading regimens. Clinical pharmacology and therapeutics, 1981, Volume: 29, Issue:4 Topics: Anti-Arrhythmia Agents; Humans; Infusions, Parenteral; Injections, Intravenous; Kinetics; Mathematics; Models, Biological; Pharmaceutical Preparations; Piperidines	1981
Electrophysiologic effects of pirmenol, its metabolite 2, and enantiomers, on cardiac Purkinje fibers. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:3 Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electrophysiology; In Vitro Techniques; Piperidines; Purkinje Fibers; Stereoisomerism	1993
Isolation and structure elucidation of the major photodegradation products of pirmenol hydrochloride. Journal of pharmaceutical sciences, 1994, Volume: 83, Issue:9 Topics: Anti-Arrhythmia Agents; Chromatography, Thin Layer; Kinetics; Light; Magnetic Resonance Spectroscopy; Mass Spectrometry; Photochemistry; Piperidines; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet	1994
Pharmacokinetics and pharmacodynamics of pirmenol enantiomers in coronary artery ligated dogs. Journal of pharmaceutical sciences, 1997, Volume: 86, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arteries; Blood Proteins; Coronary Vessels; Dogs; Piperidines; Stereoisomerism	1997
Pharmacokinetics of pirmenol enantiomers and pharmacodynamics of pirmenol racemate in patients with premature ventricular contractions. Journal of clinical pharmacology, 1997, Volume: 37, Issue:6 Topics: Adult; Aged; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Myocardial Contraction; Piperidines; Protein Binding; Stereoisomerism	1997
Pirmenol inhibits muscarinic acetylcholine receptor-operated K+ current in the guinea pig heart. European journal of pharmacology, 1997, Oct-29, Volume: 338, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Carbachol; Disopyramide; Electric Stimulation; Guinea Pigs; Heart; Patch-Clamp Techniques; Piperidines; Potassium Channels; Receptors, Muscarinic	1997
Sex difference in the metabolism of pirmenol in rats. Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:12 Topics: Animals; Anti-Arrhythmia Agents; Biotransformation; Chromatography, High Pressure Liquid; Female; Glucuronates; Glucuronidase; Hydrolysis; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Piperidines; Rats; Rats, Sprague-Dawley; Sex Characteristics	1997
Effects of pirmenol on action potentials and membrane currents in single atrial myocytes. European journal of pharmacology, 1998, Mar-05, Volume: 344, Issue:2-3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Guinea Pigs; Heart; Heart Atria; Patch-Clamp Techniques; Piperidines; Rabbits	1998
Pirmenol hydrochloride-induced QT prolongation and T wave inversion on electrocardiogram during treatment for symptomatic atrial fibrillation. Journal of UOEH, 1998, Dec-01, Volume: 20, Issue:4 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Female; Humans; Long QT Syndrome; Middle Aged; Piperidines	1998
Population pharmacokinetic analysis of pirmenol in healthy volunteers and patients with arrhythmia. European journal of clinical pharmacology, 1999, Volume: 55, Issue:1 Topics: Age Factors; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Creatinine; Female; Humans; Male; Piperidines	1999
Therapeutic monitoring of class I antiarrhythmic agents using high-resolution electrocardiography instead of blood samples. Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:3 Topics: Aged; Anti-Arrhythmia Agents; Drug Monitoring; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged; Piperidines	2003
Decreased left atrial appendage flow velocity with atrial fibrillation caused by negative inotropic agents: report of two cases. Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:3 Topics: Atenolol; Atrial Fibrillation; Atrial Function, Left; Blood Flow Velocity; Cardiotonic Agents; Echocardiography, Transesophageal; Humans; Male; Middle Aged; Piperidines; Thromboembolism	2003
[An approach to complete the manual for determination of serum pirmenol levels]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2003, Volume: 123, Issue:11 Topics: Anti-Asthmatic Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Piperidines; Specimen Handling	2003
A patient responding to combined therapy with pirmenol and midodrine for refractory neurally mediated syncope complicated by prostatic hypertrophy. Cardiovascular drugs and therapy, 2004, Volume: 18, Issue:5 Topics: Aged; Anti-Arrhythmia Agents; Humans; Male; Midodrine; Piperidines; Prostatic Hyperplasia; Syncope, Vasovagal; Tilt-Table Test; Vasoconstrictor Agents	2004
Progressive facilitation of antegrade conduction via an accessory pathway in a patient with Wolff-Parkinson-White syndrome and permanent atrial fibrillation. Internal medicine (Tokyo, Japan), 2005, Volume: 44, Issue:12 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Bundle of His; Catheter Ablation; Electrocardiography; Follow-Up Studies; Humans; Male; Middle Aged; Piperidines; Wolff-Parkinson-White Syndrome	2005