Page last updated: 2024-08-23

pirmagrel and thromboxane b2

pirmagrel has been researched along with thromboxane b2 in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (73.08)	18.7374
1990's	7 (26.92)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chouinard, ML; Coffman, T; Hamilton, BH; Linberg, LF; Martin, LL; Pamidi, A; Rakhit, A; Simke, JP	1
Burke, TA; Danchak, M; Douglas, FL; Fomsgaard, JS; Kim, YD; Myers, AK; Peppard, J; Schaffer, AV; Viswanathan, T	1
Lin, L; Nasjletti, A	1
Cockcroft, DW; Manning, PJ; O'Byrne, PM; Stevens, WH	1
Glovsky, MM; Horvath, SJ; Morganroth, ML; Schoeneich, SO; Till, GO; Ward, PA	1
Edhag, O; Gréen, K; Henriksson, P; Rasmanis, G; Vesterqvist, O	1
Kadowitz, PJ; Mayeux, PR; McNamara, DB	1
FitzGerald, GA; Nowak, J	1
Douglas, FL; Hoover, N; Klassen, DK; Weir, MR	1
Doran, JB; FitzGerald, GA; Reilly, IA; Smith, B	1
Bitterman, H; Dragon, G; Lefer, AM; Phillips, GR	1
Butler, KD; Shand, RA; Wallis, RB	1
Lefer, AM; Mentley, R; Sun, JZ	1
Decker, K; Gyufko, K; Reinke, M; Tran-Thi, TA	1
Alijani, MR; Douglas, F; Foegh, ML; Helfrich, GB; Lim, K; Taher, SA; Turk, J	1
Ahmed, SW; Douglas, F; Foegh, ML; Franco, K; Katz, NM; Kim, YD; Ku, E; Ng, L; Siegelman, R; Wallace, RB	1
Brundage, BH; Hart, K; Kieras, K; Rich, S	1
Anner, H; Hechtman, HB; Kaufman, RP; Kobzik, L; Shepro, D; Valeri, CR	1
Lucchesi, BR; Rosenthal, G; Simpson, PJ; Smith, CB	1
DeCampli, WM; Goodwin, D; Handen, CE; Kosek, JC; Miller, DC; Mitchell, RS	1
Brigmon, L; Lawson, DL; Mehta, J; Mehta, P; Ostrowski, N	1
Friehling, TD; Kelliher, GJ; Kowey, PR; MacNab, MW; O'Connor, KM; Wetstein, L	1
FitzGerald, GA; Oates, JA	1
Cash, WD; Chertock, H; Ku, EC; McPherson, SE; Signor, C	1
Maguire, ED; Wallis, RB	1
Caspi, RR; Chan, CC; Kador, PF; Li, Q; Lopez, JS; Nussenblatt, RB; Roberge, FG	1

Trials

3 trial(s) available for pirmagrel and thromboxane b2

Article	Year
The role of thromboxane in allergen-induced asthmatic responses. The European respiratory journal, 1991, Volume: 4, Issue:6 Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Female; Humans; Imidazoles; Male; Pyridines; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes; Time Factors	1991
Preliminary observations of the acute effects of selective serum thromboxane inhibition and angiotensin converting enzyme inhibition on blood pressure and renal hemodynamics in hypertensive humans. Journal of clinical pharmacology, 1989, Volume: 29, Issue:12 Topics: Adult; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Captopril; Clinical Trials as Topic; Female; Hemodynamics; Humans; Hypertension; Imidazoles; Kidney; Middle Aged; Potassium; Prostaglandins; Pyridines; Renin-Angiotensin System; Sodium; Thromboxane B2; Thromboxane-A Synthase	1989
Increased thromboxane biosynthesis in a human preparation of platelet activation: biochemical and functional consequences of selective inhibition of thromboxane synthase. Circulation, 1986, Volume: 73, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Aged; Arteriosclerosis; beta-Thromboglobulin; Epoprostenol; Female; Humans; Imidazoles; Male; Middle Aged; Platelet Aggregation; Platelet Factor 4; Pyridines; Thromboxane B2; Thromboxane-A Synthase	1986

Other Studies

23 other study(ies) available for pirmagrel and thromboxane b2

Article	Year
Pharmacokinetics and biochemical efficacy of pirmagrel, a thromboxane synthase inhibitor, in renal allograft recipients. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:6 Topics: Adult; Half-Life; Humans; Imidazoles; Infusions, Intravenous; Kidney Transplantation; Pyridines; Radioimmunoassay; Thromboxane B2; Thromboxane-A Synthase; Transplantation, Homologous	1992
Comparison of thromboxane synthetase inhibitor and methylprednisolone effects on protamine responses in dogs. Anesthesia and analgesia, 1992, Volume: 74, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dogs; Drug Interactions; Hemodynamics; Imidazoles; Methylprednisolone; Protamines; Pyridines; Thromboxane B2; Thromboxane-A Synthase	1992
Role of endothelium-derived prostanoid in angiotensin-induced vasoconstriction. Hypertension (Dallas, Tex. : 1979), 1991, Volume: 18, Issue:2 Topics: Acetylcholine; Analysis of Variance; Angiotensin II; Animals; Aorta; Aortic Coarctation; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Endothelins; Endothelium; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Imidazoles; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Phenylephrine; Prostaglandin Endoperoxides, Synthetic; Pyridines; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Vasoconstriction	1991
C3a57-77, a C-terminal peptide, causes thromboxane-dependent pulmonary vascular constriction in isolated perfused rat lungs. The American review of respiratory disease, 1990, Volume: 141, Issue:2 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Blood Pressure; Complement C3a; Cyclooxygenase Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Lung; Male; Peptide Fragments; Perfusion; Pyridines; Rats; Thromboxane B2; Thromboxane-A Synthase; Vasoconstriction	1990
Thromboxane synthase inhibition: "endoperoxide shunt phenomenon" does not occur in healthy humans in vivo. Prostaglandins, 1990, Volume: 39, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Adult; Epoprostenol; Humans; Imidazoles; Male; Pyridines; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes	1990
Evidence for a bidirectional prostaglandin endoperoxide shunt between platelets and the bovine coronary artery. Biochimica et biophysica acta, 1989, Mar-28, Volume: 1011, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cattle; Coronary Vessels; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Epoprostenol; Humans; Imidazoles; Intramolecular Oxidoreductases; Isomerases; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Pyridines; Thromboxane B2; Thromboxane-A Synthase	1989
Redirection of prostaglandin endoperoxide metabolism at the platelet-vascular interface in man. The Journal of clinical investigation, 1989, Volume: 83, Issue:2 Topics: 6-Ketoprostaglandin F1 alpha; Bleeding Time; Blood Platelets; Blood Vessels; Epoprostenol; Gas Chromatography-Mass Spectrometry; Humans; Imidazoles; Prostaglandin Endoperoxides; Pyridines; Reference Values; Thromboxane A2; Thromboxane B2	1989
Potentiation of the protective effects of a converting enzyme inhibitor and a thromboxane synthetase inhibitor in hemorrhagic shock. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:1 Topics: Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Cathepsin D; Drug Synergism; Drug Therapy, Combination; Imidazoles; Male; Myocardial Depressant Factor; Pyridines; Rats; Rats, Inbred Strains; Shock, Hemorrhagic; Thromboxane B2; Thromboxane-A Synthase	1987
The effects of modulation of prostanoid metabolism on the thoracic platelet accumulation induced by intravenous administration of collagen in the guinea-pig. Thrombosis and haemostasis, 1986, Dec-15, Volume: 56, Issue:3 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Platelets; Chromium Radioisotopes; Collagen; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Guinea Pigs; Imidazoles; Injections, Intravenous; Platelet Aggregation; Platelet Count; Prostaglandins; Pyridines; Thorax; Thromboxane B2; Thromboxanes	1986
Potentiation of myocardial salvage by tissue type plasminogen activator in combination with a thromboxane synthetase inhibitor in ischemic cat myocardium. Circulation research, 1988, Volume: 63, Issue:3 Topics: Animals; Cats; Coronary Disease; Creatine Kinase; Drug Synergism; Hemodynamics; Imidazoles; Male; Myocardium; Necrosis; Pyridines; Thromboxane B2; Thromboxane-A Synthase; Tissue Plasminogen Activator	1988
Output and effects of thromboxane produced by the liver perfused with phorbol myristate acetate. Biological chemistry Hoppe-Seyler, 1988, Volume: 369, Issue:10 Topics: Animals; Bile; Female; Imidazoles; Kinetics; Liver; Perfusion; Prostaglandins; Pyridines; Rats; Rats, Inbred Strains; Reference Values; Sulfonamides; Tetradecanoylphorbol Acetate; Thromboxane B2; Thromboxane-A Synthase	1988
Differential effect of CGS 13080, a thromboxane synthase inhibitor, in suppressing serum and urine immunoreactive thromboxane B2 in kidney transplant patients. Transplantation proceedings, 1988, Volume: 20, Issue:1 Suppl 1 Topics: Depression, Chemical; Graft Rejection; Humans; Imidazoles; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Transplantation; Pyridines; Thromboxane B2; Thromboxane-A Synthase	1988
Effects of CGS-13080, a thromboxane inhibitor, on pulmonary vascular resistance in patients after mitral valve replacement surgery. Circulation, 1988, Volume: 78, Issue:3 Pt 2 Topics: 6-Ketoprostaglandin F1 alpha; Cardiopulmonary Bypass; Heart Valve Prosthesis; Hemodynamics; Humans; Hypertension, Pulmonary; Imidazoles; Mitral Valve; Postoperative Complications; Pulmonary Circulation; Pyridines; Thromboxane B2; Thromboxane-A Synthase; Vascular Resistance	1988
Thromboxane synthetase inhibition in primary pulmonary hypertension. Chest, 1987, Volume: 91, Issue:3 Topics: Adult; Epoprostenol; Female; Humans; Hypertension, Pulmonary; Imidazoles; Male; Middle Aged; Nifedipine; Pyridines; Thromboxane B2; Thromboxane-A Synthase	1987
A high plasma prostaglandin to thromboxane ratio protects against renal ischemia. Surgery, gynecology & obstetrics, 1987, Volume: 165, Issue:5 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Creatinine; Evaluation Studies as Topic; Ibuprofen; Imidazoles; Ischemia; Kidney; Kidney Tubular Necrosis, Acute; Male; Methacrylates; Pyridines; Rats; Thromboxane B2; Thromboxane-A Synthase	1987
Reduction in the incidence of thrombosis by the thromboxane synthetase inhibitor CGS 13080 in a canine model of coronary artery injury. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:2 Topics: Animals; Blood Pressure; Collagen; Coronary Circulation; Coronary Disease; Dogs; Heart Rate; Imidazoles; Male; Platelet Aggregation; Pyridines; Thromboxane B2; Thromboxane-A Synthase	1986
Pharmacological, hematological, and physiological effects of a new thromboxane synthetase inhibitor (CGS-13080) during cardiopulmonary bypass in dogs. The Annals of thoracic surgery, 1986, Volume: 42, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood; Cardiopulmonary Bypass; Dogs; Double-Blind Method; Drug Evaluation, Preclinical; Female; Hemodynamics; Imidazoles; Male; Platelet Count; Pyridines; Random Allocation; Thromboxane B2; Thromboxane-A Synthase; Time Factors	1986
Influence of selective thromboxane synthetase blocker CGS-13080 on thromboxane and prostacyclin biosynthesis in whole blood: evidence for synthesis of prostacyclin by leukocytes from platelet-derived endoperoxides. The Journal of laboratory and clinical medicine, 1985, Volume: 106, Issue:3 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Platelets; Calcimycin; Calcium Chloride; Collagen; Epoprostenol; Imidazoles; Indomethacin; Leukocytes; Oxidoreductases; Platelet Aggregation; Pyridines; Rabbits; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes	1985
Effect of thromboxane synthetase inhibition on vulnerability to ventricular arrhythmia following coronary occlusion. American heart journal, 1986, Volume: 111, Issue:4 Topics: Animals; Blood Pressure; Cats; Coronary Disease; Female; Heart Rate; Imidazoles; Male; Pyridines; Thromboxane B2; Thromboxane-A Synthase; Ventricular Fibrillation	1986
Selective and nonselective inhibition of thromboxane formation. Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:5 Topics: Aspirin; Blood Platelets; Collagen; Epoprostenol; Humans; Imidazoles; Male; Pyridines; Random Allocation; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes	1984
Characterization of imidazo[1,5-a]pyridine-5-hexanoic acid (CGS 13080) as a selective thromboxane synthetase inhibitor using in vitro and in vivo biochemical models. Biochemical and biophysical research communications, 1983, May-16, Volume: 112, Issue:3 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Platelets; Humans; Imidazoles; In Vitro Techniques; Male; Oxidoreductases; Prostaglandins E; Pyridines; Rats; Rats, Inbred Strains; Thromboxane B2; Thromboxane-A Synthase	1983
In vivo redirection of prostaglandin endoperoxides into 6-keto PGF1 alpha formation by thromboxane synthetase inhibitors in the rat. Thrombosis research, 1983, Oct-01, Volume: 32, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Platelets; Collagen; Imidazoles; Indoles; Indomethacin; Male; Oxidoreductases; Pyridines; Radioimmunoassay; Rats; Rats, Inbred Strains; Thrombocytopenia; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes	1983
Suppression of S-antigen-induced experimental autoimmune uveoretinitis in Lewis rats by oral administration with CGS-13080, a thromboxane synthetase inhibitor. Experimental eye research, 1993, Volume: 57, Issue:5 Topics: Animals; Antigens; Arrestin; Autoantigens; Autoimmune Diseases; Chorioretinitis; Choroid; Dinoprostone; Eye Proteins; Female; Imidazoles; Immunoglobulin G; Lymphocyte Activation; Pyridines; Rats; Rats, Inbred Lew; Retina; Thromboxane B2; Thromboxane-A Synthase	1993