piritrexim has been researched along with trimetrexate in 48 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (12.50) | 18.7374 |
| 1990's | 32 (66.67) | 18.2507 |
| 2000's | 8 (16.67) | 29.6817 |
| 2010's | 2 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hansch, C; Khwaja, TA; Selassie, CD | 1 |
| Queener, SF | 1 |
| Forsch, RA; Queener, SF; Rosowsky, A | 2 |
| Baccanari, DP; Boytos, CM; Chan, JH; Hong, JS; Joyner, SS; Kuyper, LF; Rudolph, SK; Tansik, RL | 1 |
| Gangjee, A; Kisliuk, RL; Queener, SF; Vasudevan, A | 1 |
| Gangjee, A; Mavandadi, F; McGuire, JJ; Queener, SF | 1 |
| Mota, CE; Queener, SF; Rosowsky, A; Wright, JE | 1 |
| Bertino, JR; Ercikan-Abali, E; Mota, CE; Queener, SF; Rosowsky, A; Waltham, M | 1 |
| Freisheim, JH; Heusner, JJ; McCormack, JJ; Mota, CE; Queener, SF; Rosowsky, A; Wright, JE | 1 |
| Barrows, LR; Gangjee, A; Kisliuk, RL; Queener, SF; Shi, J | 1 |
| Broom, AD; Francom, P; Gangjee, A; Queener, SF; Zhu, Y | 1 |
| Baccanari, DP; Boytos, CM; Caddell, JM; Comley, JC; Friedman, HS; Hunter, RN; Jones, ML; Joyner, SS; Knick, V; Kuyper, LF; Rudolph, SK; Stables, JN; Tansik, RL; Wilson, HR | 1 |
| Borotz, SE; Carter, RL; Hosmer, CA; Johnson, CA; Krauth, CA; Pfefferkorn, ER; Piper, JR; Queener, SF | 1 |
| Devraj, R; Gangjee, A; Queener, SF | 1 |
| Gangjee, A; Mavandadi, F; Queener, SF | 1 |
| Gangjee, A; Queener, SF; Shi, J | 1 |
| Gangjee, A; Queener, SF; Vasudevan, A | 2 |
| Griffin, RJ; Grunwaldt, JD; Lambert, PA; Meek, MA; Queener, SF; Robson, C; Schmidt, D | 1 |
| Papoulis, AT; Queener, SF; Rosowsky, A | 1 |
| Gangjee, A; Queener, SF; Zhu, Y | 1 |
| Adair, O; Gangjee, A; Queener, SF | 1 |
| Aqvist, J; Graffner-Nordberg, M; Hallberg, A; Kolmodin, K; Queener, SF | 1 |
| Adair, OO; Gangjee, A; Queener, SF | 1 |
| Chan, DC; Fu, H; Queener, SF; Rosowsky, A | 1 |
| Adair, OO; Gangjee, A; Pagley, M; Queener, SF | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Cody, V; Gangjee, A; Kisliuk, RL; Namjoshi, OA; Queener, SF; Raghavan, S | 1 |
| Cody, V; Gangjee, A; Pace, J; Queener, S; Shah, K | 1 |
| Assaraf, YG; Feder, JN; Rosowsky, A; Schimke, RT; Shane, B; Sharma, RC; Wright, JE | 1 |
| Fleming, GF; Schilsky, RL | 1 |
| Feinberg, J; Sattler, FR | 1 |
| Assaraf, YG; Schimke, RT; Sharma, RC | 1 |
| Bartlett, MS; Durkin, MM; Jay, MA; Queener, SF; Smith, JW | 1 |
| Chastang, C; Derouin, F | 1 |
| Assaraf, YG; Molina, A; Schimke, RT | 1 |
| Besserer, JA; Fry, DW; Klohs, WD; Steinkampf, RW | 1 |
| Allegra, CJ; Chabner, BA; Drake, JC; Kovacs, JA; Masur, H; Parrillo, JE; Swan, JC | 1 |
| Besserer, JA; Fry, DW | 1 |
| Bajorin, DF; Roth, BJ | 1 |
| Assaraf, YG; Borgnia, MJ | 1 |
| Bagnara, AS; Nott, SE | 1 |
| Allegra, CJ; Takimoto, CH | 1 |
| Blakley, RL; Lewis, WS; Mareya, SM; Patel, M; Sleep, SE; Sorrentino, BP; Spencer, HT | 1 |
| Fishman, JA | 1 |
| Chen, F; He, XW; Lai, JP | 1 |
| Assaraf, YG; Berman, B; Bram, E; Ifergan, I; Jansen, G; Shafran, A | 1 |
5 review(s) available for piritrexim and trimetrexate
| Article | Year |
|---|---|
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Topics: Animals; Drug Design; Humans; Immunosuppression Therapy; Molecular Structure; Opportunistic Infections; Pneumonia, Pneumocystis; Structure-Activity Relationship | 1995 |
Antifolates: the next generation.
Topics: Aminopterin; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Clinical Trials as Topic; Drug Evaluation; Folic Acid Antagonists; Forecasting; Humans; Neoplasms; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate | 1992 |
Advanced bladder cancer: the need to identify new agents in the post-M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) world.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Doxorubicin; Gallium; Gemcitabine; Humans; Ifosfamide; Methotrexate; Neoplasm Staging; Paclitaxel; Pyrimidines; Trimetrexate; Urinary Bladder Neoplasms; Vinblastine | 1995 |
New antifolates in clinical development.
Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Drugs, Investigational; Folic Acid Antagonists; Humans; Neoplasms; Pyrimidines; Quinazolines; Thiophenes; Trimetrexate | 1995 |
Treatment of infection due to Pneumocystis carinii.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Atovaquone; Clindamycin; Dapsone; Eflornithine; Humans; Macrolides; Naphthoquinones; Pentamidine; Pneumocystis; Pneumocystis Infections; Pneumonia, Pneumocystis; Pyrimidines; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate | 1998 |
43 other study(ies) available for piritrexim and trimetrexate
| Article | Year |
|---|---|
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
2,4-Diaminopyrido[3,2-d]pyrimidine inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii.
Topics: Animals; Chromatography, Thin Layer; Folic Acid Antagonists; Liver; Magnetic Resonance Spectroscopy; Pneumocystis; Pyrimidines; Rats; Spectrophotometry, Infrared; Toxoplasma | 1995 |
Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines.
Topics: Animals; Antifungal Agents; Candida albicans; Drug Design; Folic Acid Antagonists; Humans; Mice; Pyrimethamine; Pyrimidines; Quinazolines; Recombinant Proteins; Structure-Activity Relationship; Trimethoprim; Trimetrexate | 1995 |
6-substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Pneumocystis; Pyrimidines; Rats; Toxoplasma | 1995 |
Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases.
Topics: Folic Acid Antagonists; Humans; Peptide Synthases; Pyrimidines; Tumor Cells, Cultured | 1995 |
2,4-Diamino-5-chloroquinazoline analogues of trimetrexate and piritrexim: synthesis and antifolate activity.
Topics: Animals; Folic Acid Antagonists; Humans; Pyrimidines; Rats; Structure-Activity Relationship; Trimetrexate | 1994 |
2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Topics: Animals; Folic Acid Antagonists; Humans; In Vitro Techniques; Liver; Mutagenesis, Site-Directed; Pneumocystis; Quinazolines; Rats; Structure-Activity Relationship; Toxoplasma | 1995 |
2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Topics: Animals; Antineoplastic Agents; Folic Acid Antagonists; Humans; Liver; Pneumocystis; Pyrimidines; Rats; Structure-Activity Relationship; Toxoplasma; Trimetrexate | 1993 |
Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Folic Acid Antagonists; Fungal Proteins; Humans; Liver; Mice; Molecular Conformation; Neoplasms, Experimental; Oxidation-Reduction; Pneumocystis; Pneumocystis Infections; Protozoan Proteins; Pyrimidines; Rats; Structure-Activity Relationship; Toxoplasma | 1993 |
Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii.
Topics: Animals; Folic Acid; Folic Acid Antagonists; Liver; Magnetic Resonance Spectroscopy; Methylation; Pneumocystis; Rats; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Toxoplasma | 1996 |
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Neoplasms; Candidiasis; Cell Division; Cell Line; Crystallography, X-Ray; Drug Design; Drug Resistance, Multiple; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Nude; Mice, SCID; Models, Molecular; Molecular Conformation; Molecular Structure; Molecular Weight; Pneumonia, Pneumocystis; Protein Structure, Secondary; Quinazolines; Structure-Activity Relationship; Toxoplasma; Tumor Cells, Cultured | 1996 |
Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
Topics: Animals; Anti-Infective Agents; Folic Acid Antagonists; Opportunistic Infections; Pneumocystis; Pneumonia, Pneumocystis; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis; Trimetrexate | 1996 |
Synthesis and dihydrofolate reductase inhibitory activities of 2,4-diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolates.
Topics: AIDS-Related Opportunistic Infections; Animals; Folic Acid Antagonists; Liver; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1997 |
Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Topics: Animals; Enzyme Inhibitors; Folic Acid Antagonists; Liver; Magnetic Resonance Spectroscopy; Methylation; Pneumocystis; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase; Toxoplasma | 1997 |
Synthesis and biological activities of conformationally restricted, tricyclic nonclassical antifolates as inhibitors of dihydrofolate reductases.
Topics: Animals; Folic Acid Antagonists; Lactams; Liver; Molecular Conformation; Molecular Structure; Naphthyridines; Pneumocystis; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Trimetrexate | 1997 |
Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.
Topics: AIDS-Related Opportunistic Infections; Animals; Binding Sites; Folic Acid Antagonists; Humans; Indicators and Reagents; Kinetics; Liver; Mammals; Molecular Conformation; Pneumocystis; Purines; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Trimethoprim | 1997 |
Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Topics: Animals; Antineoplastic Agents; Cell Survival; Folic Acid Antagonists; Indicators and Reagents; Kinetics; Liver; Lymphoma, Large B-Cell, Diffuse; Mice; Pneumocystis; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma | 1997 |
2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Topics: Animals; Folic Acid Antagonists; Liver; Pneumocystis; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase; Toxoplasma; Trimethoprim | 1998 |
6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Inhibitory Concentration 50; Liver; Pneumocystis; Pyrimidines; Rats; Structure-Activity Relationship; Toxoplasma; Tumor Cells, Cultured | 1998 |
Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl] pyrido[2,3-d]pyrimidines.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Female; Folic Acid Antagonists; Humans; Mice; Mice, Inbred ICR; Pneumocystis; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Tumor Cells, Cultured | 1999 |
Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii.
Topics: Animals; Esters; Folic Acid Antagonists; Humans; Ligands; Liver; Male; Models, Molecular; Pneumocystis; Pyrimidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimetrexate | 2001 |
Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cricetinae; Drug Screening Assays, Antitumor; Female; Folic Acid Antagonists; Humans; Mice; Mice, Inbred BALB C; Opportunistic Infections; Pneumocystis carinii; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis | 2003 |
Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium.
Topics: Folic Acid Antagonists; Humans; Mycobacterium avium; Pneumocystis carinii; Protein Binding; Solubility; Tetrahydrofolate Dehydrogenase; Trimethoprim; Water | 2004 |
Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
Topics: Animals; Azepines; Benzazepines; Folic Acid Antagonists; Models, Molecular; Mycobacterium avium; Pneumocystis carinii; Pteridines; Rats; Solubility; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Water | 2004 |
N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase.
Topics: Animals; Binding Sites; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Liver; Molecular Structure; Pneumocystis carinii; Quinazolines; Rats; Stereoisomerism; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.
Topics: Amination; Aniline Compounds; Crystallography, X-Ray; Drug Design; Folic Acid Antagonists; Humans; Models, Molecular; Mycobacterium avium; Pneumocystis carinii; Pyridines; Pyrimidines; Recombinant Proteins; Species Specificity; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2013 |
Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.
Topics: Folic Acid Antagonists; Humans; Models, Molecular; Pneumocystis; Pneumocystis carinii; Pyrimidines; Structure-Activity Relationship; Trimethoprim | 2019 |
Characterization of the coexisting multiple mechanisms of methotrexate resistance in mouse 3T6 R50 fibroblasts.
Topics: Animals; Blotting, Northern; Blotting, Southern; Cell Line; Cell Survival; CHO Cells; Clone Cells; Cricetinae; DNA; Dose-Response Relationship, Drug; Drug Resistance; Electrophoresis, Gel, Two-Dimensional; Fibroblasts; Flow Cytometry; Folic Acid Antagonists; Hydrogen-Ion Concentration; Methotrexate; Mice; Protein Biosynthesis; Proteins; Pyrimidines; RNA; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimetrexate | 1992 |
New developments in the treatment of Pneumocystis carinii pneumonia.
Topics: Adrenal Cortex Hormones; Aerosols; Dapsone; Drug Therapy, Combination; Eflornithine; Folic Acid Antagonists; Humans; Pentamidine; Pneumonia, Pneumocystis; Pyrimidines; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate | 1992 |
A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Cell Line; Cricetinae; Drug Resistance; Folic Acid Antagonists; Gene Amplification; Membrane Glycoproteins; Methotrexate; Phenotype; Pyrimidines; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate; Verapamil | 1991 |
Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection.
Topics: Animals; Cells, Cultured; Folic Acid Antagonists; Humans; Pneumocystis; Pneumonia, Pneumocystis; Pyrimidines; Quinazolines; Rats; RNA; Trimetrexate | 1987 |
In vitro effects of folate inhibitors on Toxoplasma gondii.
Topics: Animals; Enzyme-Linked Immunosorbent Assay; Folic Acid Antagonists; Microbial Sensitivity Tests; Pyrimethamine; Pyrimidines; Quinazolines; Sulfamethoxazole; Sulfisoxazole; Toxoplasma; Trimethoprim; Trimetrexate | 1989 |
Sequential amplification of dihydrofolate reductase and multidrug resistance genes in Chinese hamster ovary cells selected for stepwise resistance to the lipid-soluble antifolate trimetrexate.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cricetinae; Drug Resistance; Fluorescein; Fluoresceins; Folic Acid Antagonists; Gene Amplification; Gene Expression; Membrane Glycoproteins; Methotrexate; Pyrimidines; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1989 |
Cross resistance of pleiotropically drug resistant P338 leukemia cells to the lipophilic antifolates trimetrexate and BW 301U.
Topics: Animals; Drug Resistance; Folic Acid Antagonists; Leukemia P388; Methotrexate; Mice; Pyrimidines; Quinazolines; Trimetrexate | 1986 |
Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolate.
Topics: Animals; Folic Acid Antagonists; Mice; Mice, Inbred BALB C; Pneumocystis; Pyrimethamine; Pyrimidines; Quinazolines; Rats; Rats, Inbred Strains; Toxoplasma; Trimetrexate | 1988 |
Characterization of trimetrexate transport in human lymphoblastoid cells and development of impaired influx as a mechanism of resistance to lipophilic antifolates.
Topics: Antimetabolites, Antineoplastic; Azides; Cell Line; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid Antagonists; Humans; Lymphocytes; Pyrimidines; Quinazolines; Sodium Azide; Trimetrexate | 1988 |
Differential reversal of lipophilic antifolate resistance in mammalian cells with modulators of the multidrug resistance phenotype.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; CHO Cells; Cricetinae; Drug Interactions; Drug Resistance; Membrane Glycoproteins; Methotrexate; Phenotype; Pyrimethamine; Pyrimidines; Quinidine; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1993 |
The toxicity of antifolates in Babesia bovis.
Topics: Animals; Babesia bovis; Folic Acid; Folic Acid Antagonists; Pyrimethamine; Pyrimidines; Quinazolines; Trimethoprim; Trimetrexate | 1993 |
Synthesis and biological evaluation of nonclassical 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines with novel side chain substituents as potential inhibitors of dihydrofolate reductases.
Topics: AIDS-Related Opportunistic Infections; Animals; Folic Acid Antagonists; Humans; Liver; Mice; Pneumocystis; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase; Toxoplasma; Trimetrexate | 1997 |
Comparison of the protection of cells from antifolates by transduced human dihydrofolate reductase mutants.
Topics: Aminopterin; Animals; Cell Survival; Drug Resistance, Neoplasm; Folic Acid Antagonists; Gene Expression; Genetic Variation; Growth Inhibitors; Humans; Kinetics; Methotrexate; Pyrimidines; Rabbits; Tetrahydrofolate Dehydrogenase; Thymidine; Transfection; Trimetrexate | 1997 |
Separation and determination of the antitumor drug piritrexim by molecularly imprinted microspheres in high-performance liquid chromatography.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Microspheres; Polymers; Pyrimidines; Trimetrexate | 2003 |
Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid Antagonists; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Lipids; Molecular Structure; Mutation; Neoplasm Proteins; Paclitaxel; Pyrimethamine; Pyrimidines; Quinazolines; Rhodamines; Transfection; Trimetrexate | 2006 |