piritrexim has been researched along with methotrexate in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (33.33) | 18.7374 |
| 1990's | 24 (57.14) | 18.2507 |
| 2000's | 1 (2.38) | 29.6817 |
| 2010's | 3 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hansch, C; Khwaja, TA; Selassie, CD | 1 |
| Coats, EA; Genther, CS; Hansch, C; Selassie, CD; Strong, CD | 1 |
| Dias, CB; Hansch, C; Khwaja, TA; Pentecost, S; Selassie, CD | 1 |
| Duch, DS; Grivsky, EM; Lee, S; Nichol, CA; Sigel, CW | 1 |
| Queener, SF | 1 |
| Gangjee, A; Mavandadi, F; McGuire, JJ; Queener, SF | 1 |
| Bertino, JR; Ercikan-Abali, E; Mota, CE; Queener, SF; Rosowsky, A; Waltham, M | 1 |
| Baccanari, DP; Boytos, CM; Caddell, JM; Comley, JC; Friedman, HS; Hunter, RN; Jones, ML; Joyner, SS; Knick, V; Kuyper, LF; Rudolph, SK; Stables, JN; Tansik, RL; Wilson, HR | 1 |
| Gangjee, A; Mavandadi, F; Queener, SF | 1 |
| Griffin, RJ; Grunwaldt, JD; Lambert, PA; Meek, MA; Queener, SF; Robson, C; Schmidt, D | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cody, V; Gangjee, A; Kisliuk, RL; Namjoshi, OA; Queener, SF; Raghavan, S | 1 |
| Boesche, M; Crowther, GJ; Dasari, KS; Drewes, G; El Bakkouri, M; Fox, AM; Ghidelli-Disse, S; He, P; Hillesland, HK; Hui, R; Jones, JC; Keyloun, KR; Krahn, MM; Lafuente-Monasterio, MJ; Leonard, SE; Leroy, D; Maly, DJ; Mo, JS; Ojo, KK; Reid, MC; Rivas, KL; Van Voorhis, WC | 1 |
| Assaraf, YG; Feder, JN; Rosowsky, A; Schimke, RT; Shane, B; Sharma, RC; Wright, JE | 1 |
| Christopherson, RI; Lyons, SD; Phillips, L; Sant, ME | 1 |
| Clendeninn, NJ; Collier, MA; Goldman, MD; Haraf, DJ; Kozloff, MF; McEvilly, JM; Mick, R; Moran, WJ; Vokes, EE; Weichselbaum, RR | 1 |
| Assaraf, YG; Schimke, RT; Sharma, RC | 1 |
| Clendeninn, NJ; Havlin, K; Huang, AT; Jones, SE; Keegan, P; Killion, K; Mennel, R; Spaulding, MB; Uen, WC | 1 |
| Christopherson, RI; Lyons, SD | 1 |
| Iland, H; Vincent, P; Wass, J; Yi, SN | 1 |
| Clendeninn, NJ; Collier, MA; Dimery, IW; Eble, ML; Jacobs, CD; Karp, D; Molina, A; Vokes, EE | 1 |
| Assaraf, YG; Molina, A; Schimke, RT | 1 |
| Donnelly, E; Feun, LG; Ganjei, P; Hussein, AM; Savaraj, N | 1 |
| Besserer, JA; Fry, DW; Klohs, WD; Steinkampf, RW | 1 |
| Bowers, SW; Duch, DS | 1 |
| Blum, MR; Clendeninn, NJ; Collier, MA; Everitt, BJ; Grebe, G; Johnson, NW; Mackars, A; Macklin, AW; Sigel, CW; Woolley, JL | 1 |
| Roos, DS; Schimke, RT | 1 |
| Iland, HJ; Laszlo, J; Sedwick, WD | 2 |
| Friedlander, ML; Slowiaczek, P; Tattersall, MH; Taylor, IW | 1 |
| Hamrell, MR | 1 |
| Brown, OE; Hamrell, M; Laszlo, J; Sedwick, WD | 1 |
| Bajorin, DF; Roth, BJ | 1 |
| Benedetto, P; Clendennin, NJ; Collier, M; Feun, LG; Savaraj, N; Waldman, S | 1 |
| Assaraf, YG; Borgnia, MJ | 1 |
| Bertino, JR; Dicker, A; Ercikan, E; Schweitzer, B; Waltham, M | 1 |
| Cvitkovic, E; Domenge, C; Gandia, D | 1 |
| Ferguson, PJ; Hanson, WG | 1 |
| de Wit, R; Kaye, SB; Roberts, JT; Scott, J; Stoter, G; Verweij, J | 1 |
| de Graaf, D; Mechetner, EB; Roninson, IB; Schimke, RT; Sharma, RC | 1 |
| Blakley, RL; Lewis, WS; Mareya, SM; Patel, M; Sleep, SE; Sorrentino, BP; Spencer, HT | 1 |
3 review(s) available for piritrexim and methotrexate
| Article | Year |
|---|---|
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Topics: Animals; Drug Design; Humans; Immunosuppression Therapy; Molecular Structure; Opportunistic Infections; Pneumonia, Pneumocystis; Structure-Activity Relationship | 1995 |
Overcoming methotrexate resistance by a lipophilic antifolate (BW 301U): from theory to models to practice.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Division; Cell Line; DNA; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia, Experimental; Methotrexate; Mice; Models, Biological; Phenotype; Pyrimethamine; Pyrimidines | 1985 |
Advanced bladder cancer: the need to identify new agents in the post-M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) world.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Doxorubicin; Gallium; Gemcitabine; Humans; Ifosfamide; Methotrexate; Neoplasm Staging; Paclitaxel; Pyrimidines; Trimetrexate; Urinary Bladder Neoplasms; Vinblastine | 1995 |
4 trial(s) available for piritrexim and methotrexate
| Article | Year |
|---|---|
Neoadjuvant PFL augmented by methotrexate and piritrexim followed by concomitant chemoradiotherapy for advanced head and neck cancer: a feasible and active approach.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Pyrimidines | 1992 |
A phase II study of piritrexim in patients with advanced squamous head and neck cancer.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Male; Methotrexate; Middle Aged; Pyrimidines | 1992 |
A phase II study of piritrexim in combination with methotrexate in recurrent and metastatic head and neck cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Drug Administration Schedule; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Pyrimidines | 1991 |
Oral piritrexim, an effective treatment for metastatic urothelial cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Female; Humans; Male; Methotrexate; Middle Aged; Pyrimidines; Urologic Neoplasms | 1993 |
35 other study(ies) available for piritrexim and methotrexate
| Article | Year |
|---|---|
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.
Topics: Biological Transport, Active; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Escherichia coli; Folic Acid Antagonists; Lacticaseibacillus casei; Mathematics; Methotrexate; Pyrimethamine; Pyrimidines; Structure-Activity Relationship; Triazines | 1985 |
Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Chickens; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia L5178; Leukemia, Experimental; Mathematics; Methotrexate; Mice; Structure-Activity Relationship; Triazines | 1984 |
Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cell Division; Folic Acid Antagonists; Humans; In Vitro Techniques; Leukemia, Myeloid; Male; Methotrexate; Pyrimidines; Rats | 1980 |
Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases.
Topics: Folic Acid Antagonists; Humans; Peptide Synthases; Pyrimidines; Tumor Cells, Cultured | 1995 |
2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Topics: Animals; Folic Acid Antagonists; Humans; In Vitro Techniques; Liver; Mutagenesis, Site-Directed; Pneumocystis; Quinazolines; Rats; Structure-Activity Relationship; Toxoplasma | 1995 |
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Neoplasms; Candidiasis; Cell Division; Cell Line; Crystallography, X-Ray; Drug Design; Drug Resistance, Multiple; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Nude; Mice, SCID; Models, Molecular; Molecular Conformation; Molecular Structure; Molecular Weight; Pneumonia, Pneumocystis; Protein Structure, Secondary; Quinazolines; Structure-Activity Relationship; Toxoplasma; Tumor Cells, Cultured | 1996 |
Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Topics: Animals; Enzyme Inhibitors; Folic Acid Antagonists; Liver; Magnetic Resonance Spectroscopy; Methylation; Pneumocystis; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase; Toxoplasma | 1997 |
Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Topics: Animals; Antineoplastic Agents; Cell Survival; Folic Acid Antagonists; Indicators and Reagents; Kinetics; Liver; Lymphoma, Large B-Cell, Diffuse; Mice; Pneumocystis; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma | 1997 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.
Topics: Amination; Aniline Compounds; Crystallography, X-Ray; Drug Design; Folic Acid Antagonists; Humans; Models, Molecular; Mycobacterium avium; Pneumocystis carinii; Pyridines; Pyrimidines; Recombinant Proteins; Species Specificity; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2013 |
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
Topics: Antimalarials; Calcium; Cell Line, Tumor; Hep G2 Cells; Humans; Malaria, Falciparum; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Plasmodium falciparum; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protozoan Proteins | 2016 |
Characterization of the coexisting multiple mechanisms of methotrexate resistance in mouse 3T6 R50 fibroblasts.
Topics: Animals; Blotting, Northern; Blotting, Southern; Cell Line; Cell Survival; CHO Cells; Clone Cells; Cricetinae; DNA; Dose-Response Relationship, Drug; Drug Resistance; Electrophoresis, Gel, Two-Dimensional; Fibroblasts; Flow Cytometry; Folic Acid Antagonists; Hydrogen-Ion Concentration; Methotrexate; Mice; Protein Biosynthesis; Proteins; Pyrimidines; RNA; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimetrexate | 1992 |
Antifolates induce inhibition of amido phosphoribosyltransferase in leukemia cells.
Topics: Amidophosphoribosyltransferase; Aminoimidazole Carboxamide; Animals; Azaserine; Folic Acid Antagonists; Leukemia, Experimental; Methotrexate; Methylthioinosine; Mice; Purines; Pyrimidines; Ribonucleotides; Tumor Cells, Cultured | 1992 |
A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Cell Line; Cricetinae; Drug Resistance; Folic Acid Antagonists; Gene Amplification; Membrane Glycoproteins; Methotrexate; Phenotype; Pyrimidines; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate; Verapamil | 1991 |
Antifolates induce primary inhibition of the de novo purine pathway prior to 5-aminoimidazole-4-carboxamide ribotide transformylase in leukemia cells.
Topics: Acyltransferases; Animals; Azaserine; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Methotrexate; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purine Nucleotides; Purines; Pyrimidines; Tumor Cells, Cultured | 1991 |
Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro.
Topics: Antineoplastic Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Division; Depression, Chemical; Drug Resistance; Folic Acid Antagonists; Humans; Interphase; Leukemia, Myeloid; Methotrexate; Mitosis; Pyrimidines; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1991 |
Sequential amplification of dihydrofolate reductase and multidrug resistance genes in Chinese hamster ovary cells selected for stepwise resistance to the lipid-soluble antifolate trimetrexate.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cricetinae; Drug Resistance; Fluorescein; Fluoresceins; Folic Acid Antagonists; Gene Amplification; Gene Expression; Membrane Glycoproteins; Methotrexate; Pyrimidines; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1989 |
Carcinomatous meningitis from transitional cell carcinoma of the bladder: case report.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Humans; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Pyrimidines; Urinary Bladder Neoplasms | 1989 |
Cross resistance of pleiotropically drug resistant P338 leukemia cells to the lipophilic antifolates trimetrexate and BW 301U.
Topics: Animals; Drug Resistance; Folic Acid Antagonists; Leukemia P388; Methotrexate; Mice; Pyrimidines; Quinazolines; Trimetrexate | 1986 |
In vivo measurement of dihydrofolate reductase and its inhibition by antifolates.
Topics: Animals; Biopterins; Brain; Folic Acid Antagonists; Injections, Intraventricular; Liver; Male; Methotrexate; Mice; Pteridines; Pterins; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase | 1988 |
Preclinical biochemical pharmacology and toxicology of piritrexim, a lipophilic inhibitor of dihydrofolate reductase.
Topics: Animals; Behavior, Animal; Dogs; Folic Acid Antagonists; Heart; Metabolic Clearance Rate; Methotrexate; Mice; Muscle, Smooth; Neoplasms, Experimental; Pyrimidines; Rats; Solubility; Tissue Distribution; Tumor Cells, Cultured | 1987 |
Toxicity of folic acid analogs in cultured human cells: a microtiter assay for the analysis of drug competition.
Topics: Animals; Cell Division; Cell Line; Drug Interactions; Drug Resistance; Gene Amplification; Humans; Leucovorin; Methotrexate; Mice; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Xeroderma Pigmentosum | 1987 |
Paradoxical effect of BW 301U, a lipophilic antifolate, on methotrexate-inhibitable deoxyuridine incorporation by human hematopoietic cells.
Topics: Antineoplastic Agents; Biological Transport; Bone Marrow; Deoxyuridine; Folic Acid Antagonists; Hematopoietic Stem Cells; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Methotrexate; Pyrimidines; Thymidine; Tritium | 1985 |
Selective toxicity of a new lipophilic antifolate, BW301U, for methotrexate-resistant cells with reduced drug uptake.
Topics: Antineoplastic Agents; Cell Line; Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Pyrimethamine; Pyrimidines | 1985 |
Inhibition of dihydrofolate reductase and cell growth by antifolates in a methotrexate-resistant cell line.
Topics: Adamantane; Animals; Aspartic Acid; Cell Division; Cell Line; Drug Resistance; Folic Acid Antagonists; Methotrexate; Mice; Pyrimethamine; Pyrimidines | 1984 |
Metabolic inhibition by a new antifolate, 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methyl-pyrido[2,3-d]pyrimidine (BW3O1U), an effective inhibitor of human lymphoid and dihydrofolate reductase-overproducing mouse cell lines.
Topics: Animals; Antimetabolites; Cell Line; Deoxyuridine; Folic Acid Antagonists; Kinetics; Lymphoid Tissue; Methotrexate; Mice; Phosphorus Radioisotopes; Pyrimidines; Tetrahydrofolate Dehydrogenase | 1982 |
Oral piritrexim in advanced bladder cancer: an effective drug after progression on MVAC chemotherapy?
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Pyrimidines; Urinary Bladder Neoplasms; Vinblastine | 1994 |
Differential reversal of lipophilic antifolate resistance in mammalian cells with modulators of the multidrug resistance phenotype.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; CHO Cells; Cricetinae; Drug Interactions; Drug Resistance; Membrane Glycoproteins; Methotrexate; Phenotype; Pyrimethamine; Pyrimidines; Quinidine; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1993 |
Effect of codon 22 mutations on substrate and inhibitor binding for human dihydrofolate reductase.
Topics: Amino Acid Sequence; Aminopterin; Codon; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Kinetics; Leucine; Methotrexate; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Pyrimidines; Recombinant Proteins; Tetrahydrofolate Dehydrogenase | 1993 |
Case report of acquired piritrexim resistance and collateral methotrexate sensitivity in recurrent squamous cell carcinoma of the head and neck.
Topics: Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Resistance; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Pyrimidines | 1993 |
Differential methotrexate toxicity between two human oral squamous carcinoma cell lines.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Mandibular Neoplasms; Methotrexate; Pyrimidines; Tetrahydrofolate Dehydrogenase; Tongue Neoplasms; Tumor Cells, Cultured | 1993 |
P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake.
Topics: Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Carrier Proteins; Cell Line; Clone Cells; Colony-Forming Units Assay; Drug Resistance, Multiple; Fibroblasts; Flow Cytometry; Folic Acid Antagonists; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Methotrexate; Mice; Neoplasm Proteins; Phleomycins; Pyrimidines; Recombinant Proteins; Retroviridae; Transfection; Vinblastine | 1996 |
Comparison of the protection of cells from antifolates by transduced human dihydrofolate reductase mutants.
Topics: Aminopterin; Animals; Cell Survival; Drug Resistance, Neoplasm; Folic Acid Antagonists; Gene Expression; Genetic Variation; Growth Inhibitors; Humans; Kinetics; Methotrexate; Pyrimidines; Rabbits; Tetrahydrofolate Dehydrogenase; Thymidine; Transfection; Trimetrexate | 1997 |