pirinixic acid has been researched along with ys 121 in 6 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| George, S; Greiner, C; Hoernig, C; Koeberle, A; Popescu, L; Schubert-Zsilavecz, M; Steinhilber, D; Syha, I; Werz, O | 1 |
| Greiner, C; Koeberle, A; Schubert-Zsilavecz, M; Werz, O; Wurglics, M; Zettl, H | 1 |
| Paulke, A; Proschak, E; Schneider, G; Schubert-Zsilavecz, M; Steri, R; Thieme, TM | 1 |
| Dittrich, M; Lamers, C; Proschak, E; Schubert-Zsilavecz, M; Steri, R | 1 |
| Gomez, RC; Hanke, T; Lamers, C; Schneider, G; Schubert-Zsilavecz, M; Werz, O | 1 |
| Gabler, M; Schubert-Zsilavecz, M | 1 |
6 other study(ies) available for pirinixic acid and ys 121
| Article | Year |
|---|---|
Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.
Topics: Aminoquinolines; Cells, Cultured; Esterification; Humans; Hypersensitivity; Inflammation; Leukocytes; Lipoxygenase; Lipoxygenase Inhibitors; Pyrimidines; Structure-Activity Relationship | 2008 |
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Topics: Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Cyclooxygenase 1; Cyclooxygenase 2; Drug Design; Enzyme Activation; Enzyme Inhibitors; Humans; Inflammation; Inhibitory Concentration 50; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Models, Chemical; Prostaglandin-E Synthases; Pyrimidines | 2008 |
Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator.
Topics: Drug Design; Models, Molecular; PPAR gamma; Pyrimidines | 2010 |
Molecular determinants for improved activity at PPARα: structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARα.
Topics: Dose-Response Relationship, Drug; Humans; Hydrogen Bonding; Molecular Docking Simulation; Molecular Structure; Mutagenesis, Site-Directed; PPAR alpha; Pyrimidines; Structure-Activity Relationship | 2014 |
Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition.
Topics: Arachidonate 5-Lipoxygenase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Intramolecular Oxidoreductases; Models, Molecular; Molecular Structure; PPAR alpha; PPAR gamma; Prostaglandin-E Synthases; Pyrimidines; Structure-Activity Relationship; Thiazoles | 2014 |
Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121).
Topics: Amines; Hydrocarbons, Halogenated; Models, Chemical; Pyrimidines | 2011 |