pirinixic acid has been researched along with simvastatin in 4 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Besnard, P; Duez, H; Grober, J; Landrier, JF; Linard, C; Percevault, F; Souidi, M; Staels, B; Thomas, C | 1 |
| Carissimi, R; Galli, C; Ghezzi, S; Mastromauro, F; Petroni, A; Risé, P | 1 |
4 other study(ies) available for pirinixic acid and simvastatin
| Article | Year |
|---|---|
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator-activated receptor-alpha-dependent.
Topics: Animals; Base Sequence; Caco-2 Cells; Carrier Proteins; Fatty Acid-Binding Proteins; Gene Expression Regulation; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Molecular Sequence Data; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Rats; RNA, Messenger; Simvastatin | 2004 |
Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells.
Topics: Anticholesteremic Agents; Arachidonic Acid; Cell Line; Cholesterol; Delta-5 Fatty Acid Desaturase; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Fatty Acid Desaturases; Fenofibrate; Humans; Linoleic Acid; Lipid Metabolism; Monocytes; Peroxisome Proliferators; PPAR alpha; PPAR gamma; Pyrimidines; RNA, Messenger; Simvastatin; Sterol Regulatory Element Binding Protein 1; Thiazolidinediones; Time Factors; Transcription, Genetic | 2007 |