Page last updated: 2024-08-16

pirinixic acid and rosiglitazone

pirinixic acid has been researched along with rosiglitazone in 103 studies

Research

Studies (103)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (10.68)	18.2507
2000's	54 (52.43)	29.6817
2010's	35 (33.98)	24.3611
2020's	3 (2.91)	2.80

Authors

Authors	Studies
Brown, PJ; Henke, BR; Sternbach, DD; Willson, TM	1
Bajji, AC; Chakrabarti, R; Juluri, S; Kalchar, S; Lohray, BB; Lohray, VB; Mamidi, NV; Misra, P; Padakanti, S; Poondra, RR; Rajagopalan, R; Vikramadithyan, RK	1
Andersen, AS; Brand, CL; Bury, PS; Fleckner, J; Jeppesen, L; Lehmann, SV; Mogensen, JP; Mortensen, SB; Panajotova, V; Pettersson, I; Polivka, Z; Rasmussen, HB; Sauerberg, P; Sindelar, K; Sturis, J; Svensson, LA; Wassermann, K; Wöldike, HF; Wulff, EM; Ynddal, L	1
Albrektsen, T; Bury, PS; Deussen, HJ; Din, N; Fleckner, J; Frederiksen, KS; Jeppesen, L; Mogensen, JP; Nehlin, J; Pettersson, I; Sauerberg, P; Svensson, LA; Wulff, EM; Ynddal, L	1
Chung, SS; Hu, W; Ko, BC; Li, Z; Liao, C; Lu, XP; Ning, ZQ; Pan, D; Shan, S; Shi, L; Tong, EH; Wong, VK; Yin, Z; Zhou, J	1
Fleckner, J; Jeppesen, L; Mogensen, JP; Nehlin, J; Pettersson, I; Sauerberg, P; Svensson, LA; Wulff, EM	1
Crestani, M; Fracchiolla, G; Fruchart, JC; Godio, C; Laghezza, A; Lavecchia, A; Loiodice, F; Mitro, N; Novellino, E; Pinelli, A; Staels, B; Tortorella, V	1
Audinot-Bouchez, V; Boutin, J; Caignard, DH; Caijo, F; Dacquet, C; Grée, R; Mosset, P; Renard, P	1
Chu, F; Feng, J; Guo, Y; Guo, Z; Lu, Y	1
Chakrabarti, R; Jain, R; Kumar, R; Raichur, S; Ramachandran, U	1
Bury, PS; Fleckner, J; Havranek, M; Jeppesen, CB; Jeppesen, L; Mogensen, JP; Olsen, GS; Pettersson, I; Pihera, P; Polivka, Z; Sauerberg, P; Wulff, EM	1
Ji, R; Tang, L; Yang, Y; Yu, J	1
Giri, S; Goel, A; Jain, M; Makadia, P; Patel, H; Patel, M; Patel, P; Pingali, H; Shah, S; Zaware, P	1
Basu, S; Giri, S; Godha, A; Goel, A; Goswami, A; Jain, M; Makadia, P; Patel, H; Patel, M; Patel, P; Patil, P; Pingali, H; Shah, S; Zaware, P	1
Carbonara, G; Fracchiolla, G; Laghezza, A; Lavecchia, A; Loiodice, F; Novellino, E; Piemontese, L; Tortorella, P; Trisolini, R	1
Aschi, M; Crestani, M; Fracchiolla, G; Gilardi, F; Godio, C; Laghezza, A; Lavecchia, A; Loiodice, F; Mazza, F; Montanari, R; Novellino, E; Pochetti, G; Saccoccia, F; Scotti, E; Tortorella, P	1
Conte Camerino, D; Fracchiolla, G; Laghezza, A; Lavecchia, A; Loiodice, F; Mazza, F; Montanari, R; Novellino, E; Piemontese, L; Pierno, S; Pochetti, G; Tortorella, P	1
Gavande, N; Hanrahan, JR; Hibbs, DE; Kim, MS; Matin, A; Roubin, RH; Salam, NK; Yang, NX	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Bahekar, R; Giri, S; Jain, M; Makadia, P; Patel, D; Patel, P; Pingali, H; Pola, S; Priyadarshini, P; Shah, M; Shah, SR; Suthar, D; Thube, B; Trivedi, C; Zaware, P	1
Basu, S; Giri, S; Gite, A; Godha, A; Goswami, A; Jain, M; Patel, P; Pingali, H; Raval, P; Raval, S; Shah, M; Suthar, D	1
Altieri, F; Azzariti, A; Cervoni, L; Crestani, M; Di Giovanni, C; Fracchiolla, G; Gilardi, F; Giudici, M; Guerrini, U; Laghezza, A; Lavecchia, A; Loiodice, F; Mitro, N; Montanari, R; Paradiso, A; Piemontese, L; Pochetti, G; Porcelli, L; Simone, GM; Tortorella, P	1
Capelli, D; Di Giovanni, C; Faliti, S; Fracchiolla, G; Iacobazzi, V; Infantino, V; Laghezza, A; Lavecchia, A; Loiodice, F; Montanari, R; Piemontese, L; Pochetti, G; Tortorella, P	1
Doddareddy, MR; Gavande, N; Groundwater, PW; Hibbs, DE; Matin, A; Nammi, S; Roubin, RH	1
Carbonara, G; Carrieri, A; Crestani, M; De Rosas, M; Fracchiolla, G; Gilardi, F; Giudici, M; Laghezza, A; Lavecchia, A; Loiodice, F; Parente, M; Piemontese, L; Tortorella, P	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Ammazzalorso, A; Amoroso, R; De Filippis, B; Di Giovanni, C; Fantacuzzi, M; Giampietro, L; Laghezza, A; Lavecchia, A; Linciano, P; Loiodice, F; Maccallini, C; Tortorella, P	1
Carbonara, G; Carrieri, A; Crestani, M; Desvergne, B; Fracchiolla, G; Gilardi, F; Laghezza, A; Lavecchia, A; Loiodice, F; Parente, M; Piemontese, L; Sblano, S; Tauro, M; Tortorella, P	1
Balaban, S; Cairns, R; Gao, Q; Grewal, T; Groundwater, PW; Hanh, J; Hibbs, DE; Hoy, AJ; Lai, F; Liao, VW; Lin, HY; Ong, JA; Sjöström, H; Váradi, L; Wood, P	1
Botros, M; Kinarivala, N; Suh, JH; Trippier, PC; Webb, P	1
Cerchia, C; Colantuoni, V; Convertini, P; Dal Piaz, F; Iacobazzi, V; Infantino, V; Laghezza, A; Lavecchia, A; Loiodice, F; Lupo, A; Piemontese, L; Sblano, S; Tortorella, P; Ziccardi, P	1
Berthelot, P; Beucher-Gaudin, M; Caignard, DH; Dacquet, C; Farce, A; Géant, A; Hennuyer, N; Ktorza, A; Lebegue, N; Leclerc, V; Pirat, C; Staels, B; Zanirato, G	1
Aursnes, M; Hansen, TV; Holen, T; Nebb, HI; Paulsen, SM; Sæther, T; Tungen, JE; Vik, A	1
Capelli, D; Cerchia, C; Crestani, M; Giudici, M; Laghezza, A; Lavecchia, A; Loiodice, F; Montanari, R; Peiretti, F; Piemontese, L; Pochetti, G; Tortorella, P	1
Gellrich, L; Heering, J; Kaiser, A; Kalinowsky, L; Kilu, W; Merk, D; Ohrndorf, J; Pollinger, J; Proschak, E; Schierle, S; Schmidt, J	1
Ammazzalorso, A; Amoroso, R; Brunetti, L; Bruno, I; Cama, A; Capone, F; Cerchia, C; De Filippis, B; Fantacuzzi, M; Ferrante, C; Florio, R; Giampietro, L; Laghezza, A; Lavecchia, A; Loiodice, F; Maccallini, C; Recinella, L; Tortorella, P; Verginelli, F	1
Arnesen, H; Haj-Yasein, NN; Hansen, TV; Matthews, J; Nebb, HI; Paulsen, SM; Soedling, H; Sylte, I; Sæther, T; Tungen, JE	1
Andreu, I; Barrachina, I; Bermejo, A; Cabedo, N; Caignard, DH; Chahboune, N; Cortes, D; Dacquet, C; El Aouad, N; Figadère, B; Franck, X; Hennuyer, N; Sanz, MJ; Staels, B; Vila, L	1
Bernabeu, Á; Cabedo, N; Cortes, D; Figadère, B; Franck, X; García, A; Hennuyer, N; Marín, P; Staels, B; Vila, L; Villarroel-Vicente, C	1
Alves, PS; Bhattacharyya, M; Brand, GD; Cummins, CL; Ferreira, TAM; Grouleff, J; Krause, H; Leite, JRSA; Liu, J; Magomedova, L; Moreira, DC; Nogueira, PCN; Oliveira, AS; Poda, G; Queiroz, FJG; Romeiro, LAS; Sahin, C; Silveira, ER; Tiefenbach, J; Uehling, D	1
Brunetti, L; Cerchia, C; Genovese, M; Gilardi, F; Laghezza, A; Lavecchia, A; Leuci, R; Loiodice, F; Paoli, P; Piemontese, L; Santi, A; Sblano, S; Thomas, A; Tortorella, P	1
Kliewer, SA; Lehmann, JM; Lenhard, JM; Morris, DC; Patel, I; Willson, TM	1
Kallen, CB; Lazar, MA	1
Ciletti, N; Deplewski, D; Kentsis, A; Rosenfield, RL	1
Albrektsen, T; Gustafsson, JA; Johansson, L; Leers, J; Treuter, E	1
Chinetti, G; Delerive, P; Fadel, A; Fruchart, JC; Habib, A; Koenig, W; Lebret, M; Maclouf, J; Merval, R; Najib, J; Staels, B; Tedgui, A; Torra, IP	1
Antonucci, M; Chapman, J; Chinetti, G; Delerive, P; Fruchart, JC; Griglio, S; Majd, Z; Najib, J; Staels, B; Torra, IP	1
Brun, S; Carmona, MC; Giralt, M; Iglesias, R; Mampel, T; Villarroya, F; Viñas, O	1
Eriksson, P; Hamsten, A; Nilsson, L; Takemura, T	1
Alexandersson, M; Bamberg, K; Bergström, M; Dahllöf, B; Edvardsson, U; Ljung, B	1
Baugé, E; Chinetti, G; Clavey, V; Copin, C; Dallongeville, J; Fruchart, J; Fruchart, JC; Mariotte, MC; Staels, B	1
Clapham, JC; Smith, SA; Teruel, T	1
Clapham, JC; Peterson, J; Smith, SA; Teruel, T	1
Chandraratna, RA; Fleck, E; Goetze, S; Graf, K; Hsueh, WA; Kim, S; Kintscher, U; Law, RE; Nagpal, S; Wakino, S	1
Anania, FA; Miyahara, T; Motomura, K; Rippe, R; Schrum, L; Tsukamoto, H; Willson, TM; Xiong, S; Yee, HF	1
Asakawa, M; Komuro, I; Masuda, Y; Nagai, T; Oka, T; Saito, T; Takano, H; Toyozaki, T	1
Brüne, B; Von Knethen A, A	1
Baek, SJ; Eling, TE; Hsi, LC; Ikawa, H; Kameda, H; Kamitani, H; Nixon, JB	1
Chapman, H; Clapham, JC; Holder, JC; Lister, CA; Moore, GB; Piercy, V; Smith, SA	1
Grüb, M; Hombach, V; Kehrle, B; Koenig, W; Kohlhammer, K; Libby, P; Marx, N; Plutzky, J	1
Chatterjee, PK; Cuzzocrea, S; Hattori, Y; McDonald, MC; Mota-Filipe, H; Pisano, B; Thiemermann, C; Wayman, NS	1
Cooney, GJ; Ellis, B; Iglesias, MA; Jensen, PB; Kraegen, EW; Larsen, PJ; Sørensen, RV; Wassermann, K; Watson, DG; Wood, L; Ye, JM	1
Gardner, DG; Liang, F; Wang, F; Zhang, S	1
Gille, J; Kaufmann, R; Meissner, M; Reisinger, K; Staels, B; Stein, M; Suske, G; Urbich, C	1
Chinetti, G; Fruchart, JC; Staels, B; Zawadski, C	1
Goya, K; Kasayama, S; Kawase, I; Kitamura, T; Kouhara, H; Kurebayashi, S; Saito, H; Sumitani, S; Xu, X; Yamamoto, H	1
Benéteau, N; Chapuis, V; Colpaert, FC; Dupont-Passelaigue, E; Junquéro, D; Lestienne, F; Patoiseau, JF; Rival, Y; Taillandier, T	1
Baldwin, GS; Ford, J; Lachal, S; Shulkes, A	1
Aebersold, R; Berger, JP; Collins, SJ; Dai, H; Doyle, MJ; Eng, J; Feetham, MC; Goodlett, D; Gunter, B; Hanlon, WA; Hood, LE; Linseley, PS; Mao, M; Stepaniants, SB; Stoughton, RB; Thorsson, V; Tian, Q; Weng, L; Yi, EC	1
De Champlain, J; Wang, R; Wilson, TW; Wu, L	1
Akerblad, P; Améen, C; Asp, L; Edvardsson, U; Lindén, D; Ljungberg, A; Olofsson, SO; Oscarsson, J; Tuneld, A	1
Haas, C; Häring, HU; Kaltenbach, S; Machicao, F; Staiger, H; Stumvoll, M; Weisser, M	1
Johnson, TE; Shi, S; Umbenhauer, DR; Zhang, X	1
Hada, Y; Ito, Y; Kadowaki, T; Maki, T; Takekawa, S; Tsuchida, A; Yamauchi, T	1
Benton, CR; Bonen, A; Calles-Escandon, J; Glatz, JF; Heikkila, JJ; Koonen, DP; Luiken, JJ; Tandon, NN	1
Brameld, JM; Flux, C; Hurley, MS; Salter, AM	1
Cai, ZF; Guo, ZR; Li, PP; Liu, Q; Shen, ZF	1
Caguyong, MJ; Cornwell, PD; Dai, X; De Souza, AT; Ulrich, RG	1
Chen, YT; Li, PP; Liu, Q; Lu, XP; Ning, ZQ; Shan, S; Shen, ZF; Sun, SJ; Xie, MZ	1
Arnerup, G; Dahllöf, B; Ebefors, K; Kanmert, I; Kerb, S; Lanne, B; Lindahl, C; Miliotis, T; Nyström, AC; Oakes, N; Paulsons, I; von Bahr, H	1
Chadburn, A; Csernus, B; Hyjek, E; Jo, SH; Liu, Y; Wang, YL; Yang, C	1
Kersten, S; Lichtenauer-Kaligis, E; Mandard, S; Müller, M; Richardson, TA; Stienstra, R; Tan, NS; Trautwein, C; Wahli, W	1
Binder, BR; Blüml, S; Bochkov, VN; Exner, M; Fürnkranz, A; Ikonomu, E; Kadl, A; Krönke, G; Leitinger, N; Sarembock, IJ	1
De Windt, LJ; Smeets, PJ; Teunissen, BE; Van Bilsen, M; Van der Vusse, GJ; Willemsen, PH	1
Jacobsson, A; Jörgensen, JA; Zadravec, D	1
Bronfman, M; Leisewitz, AV; Loyola, G; Martinez, GR; Urrutia, CR	1
Baumrucker, CR; Bionaz, M; Block, E; Shirk, E; Vanden Heuvel, JP; Varga, GA	1
Gosker, HR; Langen, RC; Remels, AH; Russell, AP; Schols, AM; Schrauwen, P; Spaapen, F; Voncken, JW	1
He, JG; Lu, XH; Lv, GP; Si, SY; Zhang, H; Zhao, BH; Zheng, ZH	1
Bernd, A; Kaufmann, R; Kippenberger, S; Müller, J; Ochsendorf, F; Schuster, M; Thaçi, D; Zouboulis, CC	1
Dörffel, K; Haemmerle, G; Mayer, B; Schrammel, A; Wölkart, G; Zechner, R	1
He, X; Jiang, Q; Jiang, W; Li, Z; Liu, Z; Lu, X; Shao, H; Si, S; Xu, Y; Yang, Y; Zhang, H; Zhao, B; Zheng, Z	1
Leung, SW; Man, RY; Qu, C; Vanhoutte, PM	1
Bogacka, I; Bogacki, M; Gaglewska, M; Kurzynska, A; Wasielak, M	1
Bogacka, I; Bogacki, M; Chojnowska, K; Kurzyńska, A	2
Bernier, M; Calleri, E; Capelli, D; Dossou, KSS; Laghezza, A; Loiodice, F; Massolini, G; Moaddel, R; Montanari, R; Pochetti, G; Prada, E	1
Huan, Y; Liu, Q; Liu, ZZ; Peng, K; Shen, ZF	1
Abbott, BD; Lin, MT; Watkins, AM; Wood, CR	1
Ahn, YH; Bae, JH; Im, SS; Kang, HS; Kim, MY; Kim, SJ; Kim, YD; Lee, JH; Oh, GT; Seo, YK; Song, DK	1
Agarwal, AK; Garg, A; Sankella, S	1
Berge, RK; Bjørndal, B; Dierkes, J; Grinna, ML; Lysne, V; Midttun, Ø; Nygård, O; Strand, E; Ueland, PM	1

Reviews

1 review(s) available for pirinixic acid and rosiglitazone

Article	Year
The PPARs: from orphan receptors to drug discovery. Journal of medicinal chemistry, 2000, Feb-24, Volume: 43, Issue:4 Topics: Animals; Diabetes Mellitus; Drug Design; Humans; Hyperlipidemias; Hypertension; Inflammation; Ligands; Models, Molecular; Neoplasms; Nuclear Proteins; Obesity; Receptors, Cytoplasmic and Nuclear; Transcription Factors	2000

Other Studies

102 other study(ies) available for pirinixic acid and rosiglitazone

Article	Year
(-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity. Journal of medicinal chemistry, 2001, Aug-02, Volume: 44, Issue:16 Topics: Animals; Biological Availability; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Hyperlipidemias; Hypoglycemic Agents; Insulin Resistance; Mice; Oxazines; Phenylpropionates; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Stereoisomerism; Transcription Factors; Triglycerides	2001
Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity. Journal of medicinal chemistry, 2002, Feb-14, Volume: 45, Issue:4 Topics: Animals; Blood Glucose; Carbazoles; Cholesterol; Cholesterol, Dietary; Crystallography, X-Ray; Drug Evaluation, Preclinical; Glucose Tolerance Test; Hypoglycemic Agents; Hypolipidemic Agents; Male; Mice; Models, Molecular; Nuclear Proteins; Phenylpropionates; Pioglitazone; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides	2002
Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo. Journal of medicinal chemistry, 2003, Nov-06, Volume: 46, Issue:23 Topics: Alkenes; Amino Acid Sequence; Animals; Binding Sites; Biological Availability; Cell Line; Crystallography, X-Ray; Dimerization; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Sequence Data; Propionates; Rats; Receptors, Cytoplasmic and Nuclear; Sequence Alignment; Stereoisomerism; Transcription Factors; Transcriptional Activation	2003
Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators. Bioorganic & medicinal chemistry letters, 2004, Jul-05, Volume: 14, Issue:13 Topics: Adipose Tissue; Administration, Oral; Aldehydes; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Design; Hypolipidemic Agents; Ketones; Lipid Metabolism; Mice; PPAR alpha; PPAR delta; PPAR gamma; Structure-Activity Relationship	2004
Structure-activity relationships of dimeric PPAR agonists. Bioorganic & medicinal chemistry letters, 2005, Mar-01, Volume: 15, Issue:5 Topics: Dimerization; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Peroxisome Proliferator-Activated Receptors; Structure-Activity Relationship	2005
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity. Journal of medicinal chemistry, 2005, Aug-25, Volume: 48, Issue:17 Topics: 3T3 Cells; Adipocytes; Animals; Binding Sites; Cell Differentiation; Cell Line, Tumor; Clofibric Acid; Endopeptidase K; Fibroblasts; Humans; Ligands; Mice; Models, Molecular; Phenylpropionates; PPAR alpha; PPAR gamma; Protein Conformation; Quantitative Structure-Activity Relationship; Stereoisomerism; Trypsin	2005
Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs. Bioorganic & medicinal chemistry letters, 2005, Oct-15, Volume: 15, Issue:20 Topics: Animals; COS Cells; Drug Evaluation, Preclinical; Hydroxyeicosatetraenoic Acids; PPAR alpha; PPAR gamma	2005
Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists. Bioorganic & medicinal chemistry letters, 2006, Feb-15, Volume: 16, Issue:4 Topics: Cell Line; Cinnamates; Drug Design; Humans; In Vitro Techniques; Models, Molecular; Molecular Structure; PPAR alpha; PPAR gamma; Protein Conformation; Protein Structure, Secondary; Quantitative Structure-Activity Relationship	2006
Synthesis and evaluation of N-acetyl-L-tyrosine based compounds as PPARalpha selective activators. European journal of medicinal chemistry, 2007, Volume: 42, Issue:4 Topics: Binding Sites; Cell Line; Computer Simulation; Drug Evaluation, Preclinical; Models, Biological; Molecular Structure; Plasmids; PPAR alpha; Transcriptional Activation; Transfection; Tyrosine	2007
Design of potent PPARalpha agonists. Bioorganic & medicinal chemistry letters, 2007, Jun-01, Volume: 17, Issue:11 Topics: Animals; Computers; Crystallography; Drug Design; Ligands; Phenylpropionates; PPAR alpha	2007
Synthesis and evaluation of a series of benzopyran derivatives as PPAR alpha/gamma agonists. European journal of medicinal chemistry, 2008, Volume: 43, Issue:11 Topics: Benzopyrans; Cell Line, Tumor; Humans; Molecular Structure; PPAR alpha; PPAR gamma; Structure-Activity Relationship	2008
Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists. Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15 Topics: Animals; Carboxylic Acids; Diabetes Mellitus; Drug Design; Hypoglycemic Agents; Mice; Mice, Inbred NOD; Molecular Structure; Oxazoles; PPAR alpha; PPAR gamma; Rats; Rats, Zucker; Structure-Activity Relationship	2008
Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent. Bioorganic & medicinal chemistry letters, 2008, Oct-15, Volume: 18, Issue:20 Topics: Animals; Carboxylic Acids; Diabetes Mellitus, Type 2; Dioxanes; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Lipids; Mesylates; Mice; Models, Chemical; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR gamma; Rats; Rats, Wistar; Transcriptional Activation	2008
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity. Bioorganic & medicinal chemistry, 2008, Nov-01, Volume: 16, Issue:21 Topics: Binding Sites; Cell Line, Tumor; Computer Simulation; Hepatoblastoma; Humans; Liver Neoplasms; Models, Molecular; Molecular Structure; PPAR alpha; PPAR gamma; Propionates; Structure-Activity Relationship; Thermodynamics	2008
Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. Journal of medicinal chemistry, 2008, Dec-25, Volume: 51, Issue:24 Topics: Animals; Biphenyl Compounds; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Humans; Hypoglycemic Agents; Ligands; Mice; Models, Chemical; Models, Molecular; Molecular Conformation; Phenylpropionates; PPAR alpha; PPAR gamma; Protein Conformation; Protein Structure, Tertiary	2008
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function. Journal of medicinal chemistry, 2009, Oct-22, Volume: 52, Issue:20 Topics: Animals; Cell Line, Tumor; Chloride Channels; Chlorides; Clofibric Acid; Crystallography, X-Ray; Drug Discovery; Electric Conductivity; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ligands; Male; Models, Molecular; Molecular Conformation; Muscle, Skeletal; Muscular Diseases; PPAR alpha; PPAR gamma; Propionates; Rats; Rats, Wistar; Rest; Stereoisomerism; Substrate Specificity	2009
7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists. Journal of medicinal chemistry, 2009, Nov-12, Volume: 52, Issue:21 Topics: Benzopyrans; Cell Line; Humans; PPAR alpha; PPAR gamma; Structure-Activity Relationship	2009
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists. Bioorganic & medicinal chemistry, 2011, Jan-15, Volume: 19, Issue:2 Topics: Animals; Cricetinae; Disease Models, Animal; Ether; Hep G2 Cells; Humans; Hypoglycemic Agents; Male; Mice; Mice, Obese; Oximes; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR delta; PPAR gamma; Structure-Activity Relationship; Thiazoles	2011
Revisiting glitazars: thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents. Bioorganic & medicinal chemistry letters, 2011, May-15, Volume: 21, Issue:10 Topics: Administration, Oral; Animals; Cell Line; Dose-Response Relationship, Drug; Hypoglycemic Agents; Inhibitory Concentration 50; Mice; Molecular Structure; Oxazoles; Phenylpropionates; PPAR alpha; PPAR gamma; Protein Binding; Rats; Rats, Wistar; Rosiglitazone; Thiazolidinediones; Thiophenes	2011
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1 Topics: Adipocytes; Animals; Antineoplastic Agents; Benzoxazoles; Body Weight; Calorimetry; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Partial Agonism; Drug Screening Assays, Antitumor; Fibric Acids; Fibroblasts; Gene Expression Profiling; Humans; Insulin Resistance; Intra-Abdominal Fat; Liver; Mice; Mice, Inbred C57BL; Models, Molecular; PPAR alpha; PPAR gamma; Propionates; Stereoisomerism; Structure-Activity Relationship; Urea	2012
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression. Journal of medicinal chemistry, 2013, Jan-10, Volume: 56, Issue:1 Topics: Calorimetry; Carnitine O-Palmitoyltransferase; Cell Line, Tumor; Crystallography, X-Ray; Humans; Membrane Transport Proteins; Mitochondrial Proteins; Molecular Docking Simulation; PPAR alpha; PPAR gamma; Propionates; Protein Conformation; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; Transcriptional Activation; Up-Regulation	2013
The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists. Bioorganic & medicinal chemistry, 2013, Feb-01, Volume: 21, Issue:3 Topics: Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Isoflavones; Models, Molecular; Molecular Structure; Peroxisome Proliferator-Activated Receptors; Structure-Activity Relationship	2013
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists. European journal of medicinal chemistry, 2013, Volume: 63 Topics: Algorithms; Amino Acid Sequence; Binding Sites; Binding, Competitive; Clofibric Acid; Computer Simulation; Crystallography, X-Ray; Hep G2 Cells; Humans; Hypolipidemic Agents; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Phenylacetates; PPAR alpha; PPAR gamma; Protein Structure, Tertiary; Quantitative Structure-Activity Relationship; Thermodynamics	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Structural development studies of PPARs ligands based on tyrosine scaffold. European journal of medicinal chemistry, 2015, Jan-07, Volume: 89 Topics: Dose-Response Relationship, Drug; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Peroxisome Proliferator-Activated Receptors; Structure-Activity Relationship; Tyrosine	2015
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175. European journal of medicinal chemistry, 2015, Jan-27, Volume: 90 Topics: Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Oximes; PPAR alpha; PPAR gamma; Structure-Activity Relationship	2015
Identification of dual PPARα/γ agonists and their effects on lipid metabolism. Bioorganic & medicinal chemistry, 2015, Dec-15, Volume: 23, Issue:24 Topics: 3T3-L1 Cells; Animals; Cell Line; Diabetes Mellitus, Type 2; Drug Design; HEK293 Cells; Humans; Ligands; Lipid Metabolism; Mice; Molecular Docking Simulation; PPAR alpha; PPAR gamma; Small Molecule Libraries	2015
Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptor β/δ agonists with neuroprotective activity. Bioorganic & medicinal chemistry letters, 2016, Apr-15, Volume: 26, Issue:8 Topics: Dose-Response Relationship, Drug; Humans; Hydrocarbons, Iodinated; Molecular Structure; Neurodegenerative Diseases; Neuroprotective Agents; Organophosphorus Compounds; Polyynes; PPAR delta; PPAR-beta; Structure-Activity Relationship	2016
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity. European journal of medicinal chemistry, 2017, Feb-15, Volume: 127 Topics: Antineoplastic Agents; Benzhydryl Compounds; beta Catenin; Carnitine; Cell Proliferation; Drug Evaluation, Preclinical; Hep G2 Cells; HT29 Cells; Humans; Insulin Resistance; Mitochondria; Molecular Docking Simulation; PPAR alpha; PPAR gamma; Protein Conformation; Signal Transduction	2017
Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression. European journal of medicinal chemistry, 2017, Sep-08, Volume: 137 Topics: Animals; Body Weight; Caloric Restriction; Cells, Cultured; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; Gene Expression Profiling; Hypoglycemic Agents; Immediate-Early Proteins; Ligands; Male; Mice; Mice, Obese; Molecular Docking Simulation; Molecular Structure; PPAR gamma; Protein Serine-Threonine Kinases; Sirtuin 1; Structure-Activity Relationship	2017
Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects. European journal of medicinal chemistry, 2018, Jul-15, Volume: 155 Topics: Animals; Cells, Cultured; Chlorocebus aethiops; COS Cells; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Keto Acids; Microalgae; Molecular Structure; Palmitic Acids; PPAR alpha; PPAR gamma; Structure-Activity Relationship	2018
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation. Journal of medicinal chemistry, 2018, 09-27, Volume: 61, Issue:18 Topics: 3T3-L1 Cells; Animals; Crystallography, X-Ray; Cyclin-Dependent Kinase 5; Drug Discovery; Enzyme Inhibitors; Hep G2 Cells; Humans; Mice; Models, Molecular; Molecular Structure; Phosphorylation; PPAR alpha; PPAR gamma; Propionates; Protein Conformation; Structure-Activity Relationship	2018
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation. Journal of medicinal chemistry, 2019, 02-28, Volume: 62, Issue:4 Topics: Animals; HEK293 Cells; Hep G2 Cells; Humans; Male; Mice, Inbred C57BL; Microsomes, Liver; Molecular Structure; Peroxisome Proliferator-Activated Receptors; Pyrimidines; Rats; Retinoid X Receptors; Structure-Activity Relationship	2019
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. ACS medicinal chemistry letters, 2019, Apr-11, Volume: 10, Issue:4 Topics:	2019
Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist. Bioorganic & medicinal chemistry, 2019, 09-15, Volume: 27, Issue:18 Topics: Fatty Acids; Humans; Isoxazoles; Models, Molecular; PPAR alpha	2019
Synthesis of benzopyran derivatives as PPARα and/or PPARγ activators. Bioorganic & medicinal chemistry, 2019, 12-15, Volume: 27, Issue:24 Topics: Benzopyrans; Drug Discovery; Molecular Structure; PPAR alpha; PPAR gamma; Structure-Activity Relationship	2019
Synthesis of 2-Prenylated Alkoxylated Benzopyrans by Horner-Wadsworth-Emmons Olefination with PPARα/γ Agonist Activity. ACS medicinal chemistry letters, 2021, Nov-11, Volume: 12, Issue:11 Topics:	2021
Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases. Journal of medicinal chemistry, 2022, 02-10, Volume: 65, Issue:3 Topics: 3T3-L1 Cells; Anacardic Acids; Anacardium; Animals; Drug Design; Gene Expression; HEK293 Cells; Humans; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Nuts; PPAR alpha; PPAR delta; PPAR gamma; Protein Domains; Zebrafish	2022
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity. European journal of medicinal chemistry, 2022, May-05, Volume: 235 Topics: Cheminformatics; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Ligands; Lipids; Peroxisome Proliferator-Activated Receptors; PPAR gamma	2022
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell, 1995, Dec-01, Volume: 83, Issue:5 Topics: Adipocytes; Animals; Binding, Competitive; Cell Differentiation; Cells, Cultured; Fibroblasts; Hypoglycemic Agents; Ligands; Mice; Microbodies; Prostaglandin D2; Prostaglandins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation	1995
Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. Proceedings of the National Academy of Sciences of the United States of America, 1996, Jun-11, Volume: 93, Issue:12 Topics: 3T3 Cells; Adipocytes; Animals; Base Sequence; Gene Expression Regulation; Hypoglycemic Agents; Leptin; Mice; Molecular Sequence Data; Obesity; Oligodeoxyribonucleotides; Protein Binding; Proteins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors	1996
Mechanisms of androgen induction of sebocyte differentiation. Dermatology (Basel, Switzerland), 1998, Volume: 196, Issue:1 Topics: Androgens; Animals; Cell Differentiation; Cells, Cultured; Dihydrotestosterone; Linoleic Acid; Lipids; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Sebaceous Glands; Thiazoles; Thiazolidinediones; Transcription Factors	1998
A regulatory role for RIP140 in nuclear receptor activation. Molecular endocrinology (Baltimore, Md.), 1998, Volume: 12, Issue:6 Topics: Adaptor Proteins, Signal Transducing; Alitretinoin; Amino Acid Sequence; Animals; Binding, Competitive; Cell Nucleus; Cloning, Molecular; Dimerization; DNA-Binding Proteins; Fatty Acids; Gene Expression Regulation; Gene Library; Histone Acetyltransferases; Humans; Macromolecular Substances; Molecular Sequence Data; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Coactivator 1; Nuclear Receptor Coactivators; Nuclear Receptor Interacting Protein 1; Oncogene Proteins; Pyrimidines; Rabbits; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Receptors, Thyroid Hormone; Recombinant Fusion Proteins; Repressor Proteins; Retinoid X Receptors; Rosiglitazone; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Tretinoin; Zinc Fingers	1998
Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators. Nature, 1998, Jun-25, Volume: 393, Issue:6687 Topics: Acute-Phase Proteins; Animals; Anti-Inflammatory Agents; Aorta; Coronary Disease; COS Cells; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fenofibrate; Gemfibrozil; Gene Expression Regulation, Enzymologic; Humans; Hyperlipidemias; Hypolipidemic Agents; Inflammation; Interleukin-1; Interleukin-6; Isoenzymes; Membrane Proteins; Muscle, Smooth, Vascular; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic	1998
Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages. The Journal of biological chemistry, 1998, Oct-02, Volume: 273, Issue:40 Topics: Apoptosis; Arteriosclerosis; Caspase 3; Caspases; Cell Differentiation; Humans; Immunohistochemistry; Inflammation; Interferon-gamma; Ligands; Macrophages; NF-kappa B; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha	1998
Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth. Diabetes, 1999, Volume: 48, Issue:6 Topics: Animals; Bezafibrate; Carrier Proteins; Clofibrate; DNA-Binding Proteins; Eating; Fatty Acids, Nonesterified; Female; Gene Expression Regulation, Developmental; Hypolipidemic Agents; Ion Channels; Leptin; Male; Mice; Mitochondria, Muscle; Mitochondrial Proteins; Muscle Development; Muscle, Skeletal; Peroxisome Proliferators; Proteins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Uncoupling Protein 3	1999
Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 1999, Volume: 19, Issue:6 Topics: Bezafibrate; Cells, Cultured; Clofibric Acid; Endothelium, Vascular; Fenofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Plasminogen Activator Inhibitor 1; Pyrimidines; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription, Genetic	1999
Rosiglitazone (BRL49653), a PPARgamma-selective agonist, causes peroxisome proliferator-like liver effects in obese mice. Journal of lipid research, 1999, Volume: 40, Issue:7 Topics: Animals; Electrophoresis, Gel, Two-Dimensional; Hypoglycemic Agents; Liver; Male; Mice; Mice, Obese; Obesity; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors	1999
Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma HepG2 cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 1999, Volume: 9, Issue:3 Topics: Animals; Anticholesteremic Agents; Apolipoprotein C-III; Apolipoproteins; Apolipoproteins C; Blood; Carcinoma, Hepatocellular; Cattle; Culture Media; DNA-Binding Proteins; Fenofibrate; Gemfibrozil; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Kinetics; Liver Neoplasms; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured	1999
PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes. Biochemical and biophysical research communications, 1999, Oct-22, Volume: 264, Issue:2 Topics: Adipose Tissue, Brown; Alitretinoin; Animals; Carrier Proteins; Cells, Cultured; Gene Expression Regulation; Ion Channels; Membrane Proteins; Mitochondrial Proteins; Peroxisome Proliferators; Promoter Regions, Genetic; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tretinoin; Uncoupling Protein 1	1999
Synergistic activation of UCP-3 expression in cultured fetal rat brown adipocytes by PPARalpha and PPARgamma ligands. Biochemical and biophysical research communications, 2000, Jul-05, Volume: 273, Issue:2 Topics: Adipose Tissue, Brown; Animals; Base Sequence; Carrier Proteins; Cells, Cultured; DNA Primers; Drug Synergism; Gene Expression Regulation; Ion Channels; Ligands; Membrane Proteins; Mitochondrial Proteins; Peroxisome Proliferators; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Uncoupling Protein 1; Uncoupling Protein 3	2000
Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes. European journal of pharmacology, 2000, Aug-11, Volume: 401, Issue:3 Topics: 5,8,11,14-Eicosatetraynoic Acid; Cell Movement; Chemokine CCL2; Chemotaxis; Chromans; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Monocytes; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Rosiglitazone; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Tissue Inhibitor of Metalloproteinase-1; Transcription Factors; Troglitazone; Tumor Cells, Cultured	2000
Peroxisome proliferator-activated receptors and hepatic stellate cell activation. The Journal of biological chemistry, 2000, Nov-17, Volume: 275, Issue:46 Topics: Animals; Cell Size; Cell Survival; Cells, Cultured; Collagen; DNA; Gene Expression Regulation; Liver; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Male; Promoter Regions, Genetic; Prostaglandin D2; Protein Binding; Protein Isoforms; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha	2000
Peroxisome proliferator-activated receptor activators inhibit lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes. Circulation research, 2000, Sep-29, Volume: 87, Issue:7 Topics: Animals; Cell Nucleus; Cells, Cultured; Chromans; Drug Interactions; Gemfibrozil; Hypoglycemic Agents; Lipopolysaccharides; Myocardium; NF-kappa B; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Necrosis Factor-alpha	2000
Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:2 Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Escherichia coli; Genes, Reporter; Humans; Hypoglycemic Agents; Interferon-gamma; Lipopolysaccharides; Luciferases; Macrophages; Mice; Microbodies; Monocytes; NG-Nitroarginine Methyl Ester; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Respiratory Burst; Rosiglitazone; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection	2001
Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells. Experimental cell research, 2001, Jul-01, Volume: 267, Issue:1 Topics: Adenocarcinoma; Colorectal Neoplasms; Cyclooxygenase 2; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Isoenzymes; Ligands; Membrane Proteins; Models, Biological; Prostaglandin-Endoperoxide Synthases; Pyrimidines; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha	2001
Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice. Biochemical and biophysical research communications, 2001, Aug-31, Volume: 286, Issue:4 Topics: Adiponectin; Adrenergic beta-Agonists; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Female; Gene Expression Regulation; Hormones, Ectopic; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Mice; Mice, Obese; Nerve Growth Factor; Phenethylamines; Protein Biosynthesis; Proteins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Resistin; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha	2001
PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis. Circulation research, 2002, Apr-05, Volume: 90, Issue:6 Topics: Anti-Inflammatory Agents; Arteriosclerosis; CD4-Positive T-Lymphocytes; Cells, Cultured; Fenofibrate; Graft Survival; Heart Transplantation; Humans; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Peroxisome Proliferators; Pioglitazone; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha	2002
Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:9 Topics: Adult; Animals; Cardiotonic Agents; Cell Adhesion Molecules; Cell Line; Cells, Cultured; Chemokine CCL2; Clofibrate; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Ligands; Male; Membrane Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Pioglitazone; Prostaglandin D2; Prostaglandins A; Protein Isoforms; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors	2002
PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly. American journal of physiology. Endocrinology and metabolism, 2003, Volume: 284, Issue:3 Topics: Animals; Dietary Fats; Fatty Liver; Glucose; Glucose Clamp Technique; Insulin; Insulin Resistance; Lipid Metabolism; Liver; Male; Muscle, Skeletal; Oxazines; Phenylpropionates; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors	2003
Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes. Endocrinology, 2003, Volume: 144, Issue:9 Topics: Animals; Animals, Newborn; Base Sequence; Cell Size; Cells, Cultured; Fenofibrate; Gene Expression; Heart Ventricles; Hypertrophy; Hypoglycemic Agents; Hypolipidemic Agents; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Myocytes, Cardiac; Natriuretic Peptide, Brain; Peroxisome Proliferators; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Sarcomeres; Thiazoles; Thiazolidinediones; Transcription Factors	2003
PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation. Circulation research, 2004, Feb-20, Volume: 94, Issue:3 Topics: Binding Sites; Cell Division; Cells, Cultured; Endothelial Cells; Fenofibrate; Gene Expression Regulation; Humans; Luciferases; Neovascularization, Physiologic; Peroxisome Proliferators; Promoter Regions, Genetic; Protein Binding; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; RNA, Messenger; Rosiglitazone; Sp1 Transcription Factor; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2004
Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR. Biochemical and biophysical research communications, 2004, Jan-30, Volume: 314, Issue:1 Topics: Carotid Artery Diseases; Cells, Cultured; DNA-Binding Proteins; Endothelium, Vascular; Gene Expression Regulation; Humans; Liver X Receptors; Macrophages; Orphan Nuclear Receptors; Pyrimidines; Receptors, Adiponectin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazolidinediones; Transcription Factors	2004
Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:4 Topics: Animals; Aorta; Bezafibrate; Cattle; Cells, Cultured; Dactinomycin; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Fenofibrate; Gene Expression Regulation, Enzymologic; Half-Life; Mifepristone; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection	2004
Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages. DNA and cell biology, 2004, Volume: 23, Issue:5 Topics: Acetamides; Acetates; Anilides; Cardiovascular Agents; Cell Line; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fenofibrate; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins, LDL; Macrophages; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mevalonic Acid; Monocytes; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Sterol O-Acyltransferase; Sulfonamides; Sulfonic Acids; Tetradecanoylphorbol Acetate; Thiazolidinediones; Tissue Inhibitor of Metalloproteinase-1; Transcription Factors	2004
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells. Regulatory peptides, 2004, Aug-15, Volume: 120, Issue:1-3 Topics: Bezafibrate; Cell Proliferation; Clofibrate; Clofibric Acid; Colorectal Neoplasms; Fenofibrate; Fibric Acids; Gastrins; Gemfibrozil; Humans; Hypolipidemic Agents; Ligands; Peroxisome Proliferator-Activated Receptors; Protein Precursors; Pyrimidines; Radioimmunoassay; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Vasodilator Agents	2004
Integrated genomic and proteomic analyses of gene expression in Mammalian cells. Molecular & cellular proteomics : MCP, 2004, Volume: 3, Issue:10 Topics: Animals; Cell Line; Culture Media, Conditioned; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Genetic Variation; Genomics; Hematopoietic Stem Cells; Kinetics; Liver; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Myeloid Progenitor Cells; Myelopoiesis; Oligonucleotide Array Sequence Analysis; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Protein Processing, Post-Translational; Proteins; Proteomics; Pyrimidines; RNA, Messenger; Rosiglitazone; Thiazolidinediones	2004
Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats. American journal of hypertension, 2004, Volume: 17, Issue:9 Topics: Animals; Antihypertensive Agents; Hypertension; Hypertrophy, Left Ventricular; Kidney; Male; Myocardium; Organ Size; Peroxisome Proliferators; PPAR alpha; PPAR gamma; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rosiglitazone; Tachycardia; Thiazolidinediones; Weight Gain	2004
Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver. The Journal of biological chemistry, 2005, Jan-14, Volume: 280, Issue:2 Topics: Alitretinoin; Animals; Apolipoproteins B; Carrier Proteins; Cell Line; Cells, Cultured; Dactinomycin; Gene Expression Regulation; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Transcription, Genetic; Tretinoin	2005
Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones. International journal of obesity (2005), 2005, Volume: 29, Issue:7 Topics: Adult; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Fatty Acid Desaturases; Female; Fenofibrate; Gene Expression Regulation; Humans; Hypoglycemic Agents; Male; Muscle Fibers, Skeletal; Peroxisome Proliferators; PPAR gamma; Pyrimidines; Receptors, Adiponectin; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosiglitazone; Statistics, Nonparametric; Stearoyl-CoA Desaturase; Thiazolidinediones; Troglitazone	2005
Statins and PPARalpha agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment. Toxicology and applied pharmacology, 2005, Nov-01, Volume: 208, Issue:3 Topics: Adenosine Triphosphate; Animals; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Induction; Fibrinolytic Agents; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ion Channels; Membrane Transport Proteins; Mitochondrial Proteins; Muscle Fibers, Skeletal; Muscular Diseases; Myoblasts, Skeletal; Peroxisome Proliferator-Activated Receptors; Pyrimidines; Rats; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Time Factors; Uncoupling Protein 2	2005
Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. Diabetes, 2005, Volume: 54, Issue:12 Topics: Animals; Blood Glucose; Epididymis; Glucose Tolerance Test; Hypoglycemic Agents; Inflammation; Insulin Resistance; Male; Mice; Mice, Inbred Strains; Obesity; Polymerase Chain Reaction; PPAR alpha; PPAR gamma; Pyrimidines; Receptors, Adiponectin; Receptors, Cell Surface; Rosiglitazone; Thiazolidinediones	2005
Differential effects of contraction and PPAR agonists on the expression of fatty acid transporters in rat skeletal muscle. The Journal of physiology, 2006, May-15, Volume: 573, Issue:Pt 1 Topics: Animals; CD36 Antigens; DNA-Binding Proteins; Fatty Acid-Binding Proteins; Fatty Acids; Hypoglycemic Agents; Muscle Contraction; Muscle, Skeletal; Peroxisome Proliferators; PPAR alpha; PPAR gamma; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Up-Regulation; Viral Proteins	2006
Effects of fatty acids on skeletal muscle cell differentiation in vitro. The British journal of nutrition, 2006, Volume: 95, Issue:3 Topics: Animals; Cell Differentiation; Cell Line; Cells, Cultured; Creatine Kinase; DNA; Dose-Response Relationship, Drug; Fatty Acids; Linoleic Acid; Linoleic Acids, Conjugated; Muscle, Skeletal; Myoblasts; Oleic Acid; Palmitic Acid; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Pyrimidines; Rats; Rosiglitazone; Thiazolidinediones	2006
Synthesis and anti-diabetic activity of (RS)-2-ethoxy-3-{4-[2-(4-trifluoro-methanesulfonyloxy-phenyl)-ethoxy]-phenyl}-propionic acid. Acta pharmacologica Sinica, 2006, Volume: 27, Issue:5 Topics: Animals; Arylsulfonates; Blood Glucose; Bone Neoplasms; Cell Line, Tumor; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Mice; Mice, Inbred ICR; Molecular Structure; Osteosarcoma; Phenylpropionates; PPAR alpha; PPAR-beta; Pyrimidines; Rosiglitazone; Thiazolidinediones; Triglycerides	2006
Agonists of the peroxisome proliferator-activated receptor alpha induce a fiber-type-selective transcriptional response in rat skeletal muscle. Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 92, Issue:2 Topics: Animals; Bezafibrate; Fatty Acids; Female; Fenofibrate; Gene Expression Profiling; Glucose; Hypolipidemic Agents; Liver; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; PPAR alpha; Pyrimidines; Rats; Rats, Inbred Strains; Rosiglitazone; Thiazolidinediones; Tretinoin	2006
The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. British journal of pharmacology, 2006, Volume: 148, Issue:5 Topics: Adipose Tissue; Animals; Blood Glucose; Carbazoles; Disease Models, Animal; Dyslipidemias; Gene Expression; Gluconeogenesis; Hypoglycemic Agents; Insulin Resistance; Lipids; Liver; Liver Glycogen; Muscles; Obesity; Pancreas; Pioglitazone; PPAR alpha; PPAR gamma; Propionates; Pyrimidines; Rats; Rats, Wistar; Rosiglitazone; Sodium Glutamate; Thiazolidinediones	2006
PPARalpha and PPARgamma regulation of liver and adipose proteins in obese and dyslipidemic rodents. Journal of proteome research, 2006, Volume: 5, Issue:8 Topics: Adipose Tissue; Animals; Dyslipidemias; Hypoglycemic Agents; Liver; Male; Mice; Mice, Obese; Peroxisome Proliferators; PPAR alpha; PPAR gamma; Proteome; Pyrimidines; Rats; Rats, Zucker; Rosiglitazone; Thiazolidinediones	2006
Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism. The American journal of pathology, 2007, Volume: 170, Issue:2 Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Fatty Acids; Glucose; Humans; Hypoglycemic Agents; Ligands; Lymphoma, T-Cell; Membrane Potential, Mitochondrial; Mitochondria; Neoplasm Proteins; Peroxisome Proliferators; PPAR gamma; Prostaglandin D2; Pyrimidines; Reactive Oxygen Species; Rosiglitazone; Thiazolidinediones	2007
The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. Journal of hepatology, 2007, Volume: 46, Issue:5 Topics: Animals; Anticholesteremic Agents; Carcinoma, Hepatocellular; Female; Gene Expression Regulation; Hepatitis; Hepatocytes; Humans; Hypoglycemic Agents; Interleukin 1 Receptor Antagonist Protein; Liver; Male; Mice; Mice, Knockout; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Receptors, Interleukin-1 Type I; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation	2007
Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors. Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:6 Topics: Anti-Inflammatory Agents; Cell Proliferation; Cells, Cultured; Chromans; Cyclooxygenase 2; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Induction; Enzyme Inhibitors; Fenofibrate; Heme Oxygenase-1; Humans; Membrane Proteins; Metalloporphyrins; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Polymorphism, Genetic; PPAR alpha; PPAR gamma; Promoter Regions, Genetic; Protoporphyrins; Pyrimidines; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Time Factors; Transcription, Genetic; Transfection; Troglitazone; Tumor Necrosis Factor-alpha	2007
Activation of PPARdelta inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts. Cardiovascular research, 2007, Aug-01, Volume: 75, Issue:3 Topics: Animals; Animals, Newborn; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen; Fibroblasts; Fibrosis; Humans; Immunohistochemistry; Ligands; Myocytes, Cardiac; Peroxisome Proliferators; PPAR alpha; PPAR delta; PPAR gamma; Pyrimidines; Rats; Rats, Inbred Lew; Rosiglitazone; Thiazoles; Thiazolidinediones; Transduction, Genetic	2007
Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes. American journal of physiology. Endocrinology and metabolism, 2007, Volume: 293, Issue:5 Topics: Acetyltransferases; Adipocytes; Adipose Tissue, Brown; Animals; Cell Proliferation; Cycloheximide; Dactinomycin; Drug Synergism; Fatty Acid Elongases; Gene Expression Regulation; Male; Membrane Proteins; Mice; Norepinephrine; Peroxisome Proliferators; Phenoxyacetates; PPAR gamma; Protein Synthesis Inhibitors; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Transcription, Genetic	2007
A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis. Journal of cellular physiology, 2008, Volume: 217, Issue:2 Topics: Alkyl and Aryl Transferases; Animals; Cell Differentiation; Cell Line, Tumor; Cell Lineage; Enzyme Induction; Glioma; Lipid Metabolism; Mice; Myelin Sheath; Oligodendroglia; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR gamma; PPAR-beta; Pyrimidines; Rats; Receptor Cross-Talk; RNA Interference; RNA, Small Interfering; Rosiglitazone; Thiazoles; Thiazolidinediones; Time Factors; Transcription, Genetic; Transfection	2008
Characterization of Madin-Darby bovine kidney cell line for peroxisome proliferator-activated receptors: temporal response and sensitivity to fatty acids. Journal of dairy science, 2008, Volume: 91, Issue:7 Topics: Animals; Cattle; Cell Line; Energy Metabolism; Gene Expression Regulation; Lipid Metabolism; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Rosiglitazone; Thiazolidinediones	2008
PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle. American journal of physiology. Endocrinology and metabolism, 2009, Volume: 297, Issue:1 Topics: Animals; Cells, Cultured; Cytokines; Down-Regulation; Humans; Hypoglycemic Agents; Inflammation Mediators; Male; Mice; Middle Aged; Muscle, Skeletal; NF-kappa B; PPAR gamma; Pyrimidines; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcriptional Activation	2009
Impacts of different promoters on the mammalian one-hybrid assay for detecting nuclear receptor agonists. Analytical and bioanalytical chemistry, 2010, Volume: 396, Issue:5 Topics: Animals; Bezafibrate; Cells, Cultured; Chenodeoxycholic Acid; Drug Discovery; Genetic Vectors; HeLa Cells; High-Throughput Screening Assays; Humans; Hydrocarbons, Fluorinated; Ligands; Mice; NIH 3T3 Cells; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Promoter Regions, Genetic; Pyrimidines; Rosiglitazone; Sensitivity and Specificity; Structure-Activity Relationship; Sulfonamides; Thiazolidinediones; Two-Hybrid System Techniques	2010
Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne? The British journal of dermatology, 2011, Volume: 164, Issue:1 Topics: Acne Vulgaris; Apoptosis; Blotting, Western; Bromodeoxyuridine; Cell Line; Enzyme Inhibitors; Humans; L-Lactate Dehydrogenase; Peroxisome Proliferator-Activated Receptors; Phenoxyacetates; PPAR alpha; PPAR delta; PPAR gamma; Pyrimidines; Rosiglitazone; Sebaceous Glands; Staurosporine; Thiazolidinediones	2011
Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARα agonist. British journal of pharmacology, 2012, Volume: 165, Issue:2 Topics: Animals; Anticholesteremic Agents; Body Weight; Female; Heart; Heart Rate; In Vitro Techniques; Lipase; Male; Mice; Mice, Knockout; Myocardium; Norepinephrine; Organ Size; PPAR alpha; PPAR gamma; Pyrimidines; Rosiglitazone; Thiazolidinediones; Ventricular Dysfunction, Left	2012
Two thiophenes compounds are partial peroxisome proliferator-activated receptor α/γ dual agonists. Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:10 Topics: Animals; Cell Culture Techniques; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Genes, Reporter; Hepatocytes; Humans; Hypoglycemic Agents; Mice; Molecular Targeted Therapy; Plasmids; PPAR alpha; PPAR gamma; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Sulfoxides; Thenoyltrifluoroacetone; Thiazolidinediones; Thiophenes	2011
Wy14643 improves vascular function in the aorta of the spontaneously hypertensive rat mainly by activating peroxisome proliferator-activated receptors alpha. European journal of pharmacology, 2012, Dec-05, Volume: 696, Issue:1-3 Topics: Animals; Aorta, Thoracic; Fenofibrate; Hypertension; In Vitro Techniques; Male; Peroxisome Proliferators; PPAR alpha; PPAR gamma; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rosiglitazone; Thiazolidinediones; Vasoconstriction	2012
In vitro effect of peroxisome proliferator activated receptor (PPAR) ligands on prostaglandin E2 synthesis and secretion by porcine endometrium during the estrous cycle and early pregnancy. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2013, Volume: 64, Issue:1 Topics: Animals; Dinoprostone; Endometrium; Estrous Cycle; Female; Indoles; Intramolecular Oxidoreductases; Ligands; Peroxisome Proliferator-Activated Receptors; Phenoxyacetates; Pregnancy; Prostaglandin-E Synthases; Pyrimidines; RNA, Messenger; Rosiglitazone; Swine; Thiazolidinediones	2013
The involvement of peroxisome proliferator activated receptors (PPARs) in prostaglandin F2α production by porcine endometrium. Reproductive biology, 2013, Volume: 13, Issue:4 Topics: Analysis of Variance; Anilides; Animals; Benzamides; Culture Media; Dinoprost; DNA Primers; Endometrium; Estrous Cycle; Female; Indoles; Peroxisome Proliferator-Activated Receptors; Phenoxyacetates; Pregnancy; Prostaglandin D2; Pyridines; Pyrimidines; Radioimmunoassay; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Rosiglitazone; Swine; Thiazolidinediones	2013
Resveratrol and its metabolites bind to PPARs. Chembiochem : a European journal of chemical biology, 2014, May-26, Volume: 15, Issue:8 Topics: Binding Sites; Crystallography, X-Ray; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Models, Molecular; Peroxisome Proliferator-Activated Receptors; Pyrimidines; Resveratrol; Rosiglitazone; Stilbenes; Structure-Activity Relationship; Thiazolidinediones; Tumor Cells, Cultured	2014
[Design, synthesis and antidiabetic activity of novel tetrahydrocarboline PPAR regulators]. Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:4 Topics: Animals; Carbolines; Cells, Cultured; Drug Design; Hypoglycemic Agents; Molecular Structure; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR gamma; Pyrimidines; Rosiglitazone; Structure-Activity Relationship; Thiazolidinediones; Transfection	2014
Peroxisome proliferator activated receptor ligands affect progesterone and 17β-estradiol secretion by porcine corpus luteum during early pregnancy. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2014, Volume: 65, Issue:5 Topics: 3-Hydroxysteroid Dehydrogenases; Anilides; Animals; Benzamides; Corpus Luteum; Estradiol; Estrous Cycle; Female; Gene Expression; Indoles; Ligands; Peroxisome Proliferator-Activated Receptors; Phenoxyacetates; Pregnancy; Progesterone; Prostaglandin D2; Pyridines; Pyrimidines; RNA, Messenger; Rosiglitazone; Swine; Thiazolidinediones	2014
The effects of perfluorinated chemicals on adipocyte differentiation in vitro. Molecular and cellular endocrinology, 2015, Jan-15, Volume: 400 Topics: 3T3-L1 Cells; Adipocytes; Alkanesulfonic Acids; Animals; Caprylates; Cell Differentiation; Cell Size; Environmental Pollutants; Fatty Acids; Fluorocarbons; Gene Expression Profiling; Gene Expression Regulation; Lipid Metabolism; Mice; PPAR alpha; PPAR gamma; Pyrimidines; Rosiglitazone; Signal Transduction; Stearoyl-CoA Desaturase; Thiazolidinediones	2015
Regulation of IGFBP-2 expression during fasting. The Biochemical journal, 2015, May-01, Volume: 467, Issue:3 Topics: Animals; Cells, Cultured; Fasting; Gene Expression Regulation; Hepatocytes; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor I; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxisome Proliferators; Phosphorylation; PPAR alpha; PPAR gamma; Proto-Oncogene Proteins c-akt; Pyrimidines; RNA, Messenger; Rosiglitazone; Signal Transduction; Thiazolidinediones; Up-Regulation	2015
Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells. PloS one, 2016, Volume: 11, Issue:9 Topics: Acyltransferases; Anilides; Animals; Blotting, Northern; Caco-2 Cells; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Computational Biology; HT29 Cells; Humans; Kidney Tubules, Proximal; Liver; Mice; Oxazoles; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Rats; Real-Time Polymerase Chain Reaction; Rosiglitazone; Sulfones; Thiazoles; Thiazolidinediones; Thiophenes; Tyrosine	2016
Short-term treatment with a peroxisome proliferator-activated receptor α agonist influences plasma one-carbon metabolites and B-vitamin status in rats. PloS one, 2019, Volume: 14, Issue:12 Topics: Animals; Carbon; Male; PPAR alpha; PPAR gamma; Pyrimidines; Rats; Rats, Wistar; Rosiglitazone; Time Factors; Vitamin B Complex	2019