pirinixic acid has been researched along with pioglitazone in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (46.15) | 29.6817 |
| 2010's | 13 (50.00) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, PJ; Henke, BR; Sternbach, DD; Willson, TM | 1 |
| Andersen, AS; Brand, CL; Bury, PS; Fleckner, J; Jeppesen, L; Lehmann, SV; Mogensen, JP; Mortensen, SB; Panajotova, V; Pettersson, I; Polivka, Z; Rasmussen, HB; Sauerberg, P; Sindelar, K; Sturis, J; Svensson, LA; Wassermann, K; Wöldike, HF; Wulff, EM; Ynddal, L | 1 |
| Albrektsen, T; Bury, PS; Deussen, HJ; Din, N; Fleckner, J; Frederiksen, KS; Jeppesen, L; Mogensen, JP; Nehlin, J; Pettersson, I; Sauerberg, P; Svensson, LA; Wulff, EM; Ynddal, L | 1 |
| Paulke, A; Proschak, E; Schneider, G; Schubert-Zsilavecz, M; Steri, R; Thieme, TM | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Carbonara, G; Di Giovanni, C; Fracchiolla, G; Laghezza, A; Lavecchia, A; Loiodice, F; Montanari, R; Novellino, E; Parente, M; Piemontese, L; Pochetti, G; Tortorella, P | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Ammazzalorso, A; Amoroso, R; Brunetti, L; Bruno, I; Cama, A; Capone, F; Cerchia, C; De Filippis, B; Fantacuzzi, M; Ferrante, C; Florio, R; Giampietro, L; Laghezza, A; Lavecchia, A; Loiodice, F; Maccallini, C; Recinella, L; Tortorella, P; Verginelli, F | 1 |
| Ahn, S; An, S; Gong, J; Hwang, SY; Jung, D; Kim, H; Kim, HP; Kim, J; Lee, J; Noh, M; Pyo, JJ; Shin, I | 1 |
| Banba, N; Hattori, Y; Hishinuma, A; Kakishita, H; Kasai, K; Matsumura, M; Motohashi, S; Sato, N | 1 |
| Grüb, M; Hombach, V; Kehrle, B; Koenig, W; Kohlhammer, K; Libby, P; Marx, N; Plutzky, J | 1 |
| Chatterjee, PK; Cuzzocrea, S; Hattori, Y; McDonald, MC; Mota-Filipe, H; Pisano, B; Thiemermann, C; Wayman, NS | 1 |
| Danziger, EC; Hatley, ME; Hedrick, CC; Reilly, KB; Srinivasan, S | 1 |
| Chen, YT; Li, PP; Liu, Q; Lu, XP; Ning, ZQ; Shan, S; Shen, ZF; Sun, SJ; Xie, MZ | 1 |
| Catalán, J; Giral, H; Sorribas, V; Villa-Bellosta, R | 1 |
| Bock, A; Kock, M; Rau, O; Schubert-Zsilavecz, M; Syha, Y; Zettl, H | 1 |
| Chabowski, A; Górski, J; Harasim, E; Wierzbicki, M; Zendzian-Piotrowska, M | 1 |
| Chabowski, A; Gorski, J; Wierzbicki, M; Zendzian-Piotrowska, M | 1 |
| He, JG; Lu, XH; Lv, GP; Si, SY; Zhang, H; Zhao, BH; Zheng, ZH | 1 |
| Avenia, N; Bonafé, M; Ceccarelli, C; De Carolis, S; Guarnieri, T; Orlandi, M; Papi, A; Sanguinetti, A; Santini, D; Sidoni, A; Storci, G; Taffurelli, M | 1 |
| Auwerx, J; Bertin, B; Desreumaux, P; Dubuquoy, L; El-Jamal, N | 1 |
| Byun, JH; Hah, YS; Hwang, SC; Joo, HH; Kang, YH; Kim, JW; Park, BW; Rho, GJ; Sung, IY; Woo, DK | 1 |
| Douglas, MW; George, J; McLauchlan, J; Read, SA; Shahidi, M; Tay, ES | 1 |
| Chi, Y; Ding, D; Dong, S; Gao, H; Liao, X; Lin, Y; Ye, G; Zhang, H | 1 |
| Ai, XY; Chen, J; Gao, H; Huang, Q; Wu, Z; Yang, BC; Ye, G | 1 |
1 review(s) available for pirinixic acid and pioglitazone
| Article | Year |
|---|---|
The PPARs: from orphan receptors to drug discovery.
Topics: Animals; Diabetes Mellitus; Drug Design; Humans; Hyperlipidemias; Hypertension; Inflammation; Ligands; Models, Molecular; Neoplasms; Nuclear Proteins; Obesity; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2000 |
25 other study(ies) available for pirinixic acid and pioglitazone
| Article | Year |
|---|---|
Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.
Topics: Animals; Blood Glucose; Carbazoles; Cholesterol; Cholesterol, Dietary; Crystallography, X-Ray; Drug Evaluation, Preclinical; Glucose Tolerance Test; Hypoglycemic Agents; Hypolipidemic Agents; Male; Mice; Models, Molecular; Nuclear Proteins; Phenylpropionates; Pioglitazone; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides | 2002 |
Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo.
Topics: Alkenes; Amino Acid Sequence; Animals; Binding Sites; Biological Availability; Cell Line; Crystallography, X-Ray; Dimerization; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Sequence Data; Propionates; Rats; Receptors, Cytoplasmic and Nuclear; Sequence Alignment; Stereoisomerism; Transcription Factors; Transcriptional Activation | 2003 |
Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator.
Topics: Drug Design; Models, Molecular; PPAR gamma; Pyrimidines | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists.
Topics: Binding Sites; Carboxylic Acids; Crystallography, X-Ray; Halogenation; Humans; Models, Molecular; PPAR alpha; PPAR gamma; Protein Binding; Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome.
Topics: | 2019 |
2-Phenyl-8-(1-phenylallyl)-chromenone compounds have a pan-PPAR modulator pharmacophore.
Topics: Adiponectin; Humans; Models, Molecular; PPAR gamma | 2019 |
15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes.
Topics: Anticholesteremic Agents; Arsenites; Bucladesine; Cells, Cultured; Chromans; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetal Proteins; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypoglycemic Agents; Ligands; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pioglitazone; Prostaglandin D2; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sodium Compounds; Thiazoles; Thiazolidinediones; Thyroglobulin; Thyroid Gland; Thyrotropin; Transcription Factors; Troglitazone | 2000 |
PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis.
Topics: Anti-Inflammatory Agents; Arteriosclerosis; CD4-Positive T-Lymphocytes; Cells, Cultured; Fenofibrate; Graft Survival; Heart Transplantation; Humans; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Peroxisome Proliferators; Pioglitazone; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha | 2002 |
Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.
Topics: Adult; Animals; Cardiotonic Agents; Cell Adhesion Molecules; Cell Line; Cells, Cultured; Chemokine CCL2; Clofibrate; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Ligands; Male; Membrane Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Pioglitazone; Prostaglandin D2; Prostaglandins A; Protein Isoforms; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Modulation of PPARalpha expression and inflammatory interleukin-6 production by chronic glucose increases monocyte/endothelial adhesion.
Topics: Animals; Aorta; Cell Adhesion; Diabetes Mellitus, Type 2; Endothelial Cells; Endothelium, Vascular; Glucose; Humans; Interleukin-6; Interleukin-8; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Monocytes; Pioglitazone; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Thiazolidinediones; Transcription Factors | 2004 |
The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Carbazoles; Disease Models, Animal; Dyslipidemias; Gene Expression; Gluconeogenesis; Hypoglycemic Agents; Insulin Resistance; Lipids; Liver; Liver Glycogen; Muscles; Obesity; Pancreas; Pioglitazone; PPAR alpha; PPAR gamma; Propionates; Pyrimidines; Rats; Rats, Wistar; Rosiglitazone; Sodium Glutamate; Thiazolidinediones | 2006 |
Cytotoxicity of peroxisome proliferator-activated receptor alpha and gamma agonists in renal proximal tubular cell lines.
Topics: Animals; Caspase 3; Cell Line; Cell Survival; Clofibrate; DNA Fragmentation; Hypoglycemic Agents; Hypolipidemic Agents; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; LLC-PK1 Cells; Mice; Opossums; Peroxisome Proliferators; Pioglitazone; PPAR alpha; PPAR gamma; Pyrimidines; Swine; Thiazolidinediones | 2007 |
Alpha-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma.
Topics: Humans; In Vitro Techniques; Luciferases; Peroxisome Proliferators; Pioglitazone; PPAR alpha; PPAR gamma; Pyrimidines; Structure-Activity Relationship; Thiazolidinediones | 2008 |
Chronic, in vivo, PPARalpha activation prevents lipid overload in rat liver induced by high fat feeding.
Topics: Animals; Dietary Fats; Fatty Acids; Fatty Acids, Nonesterified; Fatty Liver; Lipid Metabolism; Lipids; Liver; Male; Pioglitazone; PPAR alpha; PPAR gamma; Pyrimidines; Random Allocation; Rats; Rats, Wistar; Thiazolidinediones | 2009 |
Differential effects of in vivo PPAR alpha and gamma activation on fatty acid transport proteins expression and lipid content in rat liver.
Topics: Animals; Fatty Acid Transport Proteins; Fatty Acids; Gene Expression Regulation; Lipid Metabolism; Liver; Male; Peroxisome Proliferators; Pioglitazone; PPAR alpha; PPAR gamma; Pyrimidines; Rats; Rats, Wistar; Thiazolidinediones | 2009 |
Impacts of different promoters on the mammalian one-hybrid assay for detecting nuclear receptor agonists.
Topics: Animals; Bezafibrate; Cells, Cultured; Chenodeoxycholic Acid; Drug Discovery; Genetic Vectors; HeLa Cells; High-Throughput Screening Assays; Humans; Hydrocarbons, Fluorinated; Ligands; Mice; NIH 3T3 Cells; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Promoter Regions, Genetic; Pyrimidines; Rosiglitazone; Sensitivity and Specificity; Structure-Activity Relationship; Sulfonamides; Thiazolidinediones; Two-Hybrid System Techniques | 2010 |
Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Humans; Inflammation; Interleukin-6; Neoplastic Stem Cells; NF-kappa B; Phenanthrenes; Pioglitazone; PPAR gamma; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Thiazolidinediones; Tretinoin | 2012 |
In vivo imaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice.
Topics: Animals; Firefly Luciferin; Genes, Reporter; Luciferases; Luminescence; Male; Mice; Mice, Transgenic; Microscopy; Photons; Pioglitazone; PPAR alpha; PPAR gamma; Protein Isoforms; Pyrimidines; Response Elements; Skin; Thiazolidinediones | 2013 |
Cultured human periosteal-derived cells have inducible adipogenic activity and can also differentiate into osteoblasts in a perioxisome proliferator-activated receptor-mediated fashion.
Topics: Benzamides; Cell Differentiation; Cells, Cultured; Humans; Osteoblasts; Oxazoles; Periosteum; Peroxisome Proliferator-Activated Receptors; Pioglitazone; PPAR alpha; PPAR gamma; Pyridines; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones; Tyrosine | 2014 |
The Mechanism of Interferon Refractoriness During Hepatitis C Virus Infection and Its Reversal with a Peroxisome Proliferator-Activated Receptor α Agonist.
Topics: AMP-Activated Protein Kinases; Axl Receptor Tyrosine Kinase; Cell Line, Tumor; Drug Resistance, Viral; Gene Expression Regulation; Genes, Reporter; Hepacivirus; Hepatocytes; Host-Pathogen Interactions; Humans; Interferon-alpha; Luciferases; Metformin; Pioglitazone; PPAR alpha; PPAR gamma; Proto-Oncogene Proteins; Pyrimidines; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; STAT1 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thiazolidinediones | 2015 |
Peroxisome proliferator-activated receptor A/G reprogrammes metabolism associated with lipid accumulation in macrophages.
Topics: Amino Acids; Animals; Cholesterol Esters; Fatty Acids, Nonesterified; Gas Chromatography-Mass Spectrometry; Lipid Metabolism; Lipids; Macrophages; Mice; Oleic Acid; Peroxisome Proliferator-Activated Receptors; Pioglitazone; PPAR alpha; Pyrimidines; RAW 264.7 Cells; Transcription Factors | 2019 |
Metabolomics Insights into Oleate-Induced Disorders of Phospholipid Metabolism in Macrophages.
Topics: Animals; Chromatography, Liquid; Lipid Metabolism; Macrophages; Mass Spectrometry; Metabolic Diseases; Metabolomics; Mice; Models, Animal; Oleic Acid; Phospholipids; Pioglitazone; Pyrimidines; RAW 264.7 Cells | 2021 |