pirinixic acid has been researched along with l 663536 in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 11 (52.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Greiner, C; Koeberle, A; Schubert-Zsilavecz, M; Werz, O; Wurglics, M; Zettl, H | 1 |
| Greiner, C; Hieke, M; Schubert-Zsilavecz, M; Thieme, TM; Werz, O; Zettl, H | 1 |
| Beck, KF; Gans, A; Kaszkin, M; Pfeilschifter, J; Scholz-Pedretti, K | 1 |
| Kehrer, JP; Tong, Z; Wu, X | 1 |
| Abu-Ghazaleh, R; Avis, I; Martínez, A; Mayburd, A; Mulshine, JL; Ondrey, F; Tauler, J; Zudaire, E | 1 |
| Andrews, G; Colville-Nash, P; Freemantle, C; Lam, C; Papworth, J; Willis, D; Willoughby, D | 1 |
| Huang, TH; Li, Y; Roufogalis, BD; Tran, VH | 1 |
| Borowitz, JL; Isom, GE; Leavesley, HB; Li, L; Prabhakaran, K; Zhang, L; Zhang, X | 1 |
| Hannig, M; Piper, HM; Sauer, H; Sharifpanah, F; Wartenberg, M | 1 |
| Biserni, A; Ciana, P; Giannessi, F; Maggi, A; Milazzo, FM; Sciarroni, AF | 1 |
| Egashira, Y; Sanada, H; Sasaki, N | 1 |
| Kuwabara, H; Marunaka, Y; Mori, H; Nakahari, T; Nakano, T; Saad, AH; Sakai, A; Sawabe, Y; Shimamoto, C; Takitani, K; Tamai, H | 1 |
| Barnes, C; Fadda, P; Fratta, W; Goldberg, SR; Justinova, Z; Le Foll, B; Lecca, S; Luchicchi, A; Mascia, P; Panlilio, LV; Piomelli, D; Pistis, M; Redhi, GH; Scherma, M; Tanda, G; Yasar, S | 1 |
| Liang, CJ; Ma, YH; Tseng, CP; Yang, CM | 1 |
| Ishii, H; Masuda, Y; Saotome, D; Sasaki, T; Sugimoto, K; Takada, K | 1 |
| Ding, JL; Li, Y; Sun, XF; Wang, L; Wang, R; Zhan, L; Zhou, B; Zhou, XY; Zhou, ZG | 1 |
| Bogacka, I; Bogacki, M; Gaglewska, M; Kurzynska, A; Wasielak, M | 1 |
| Bogacka, I; Bogacki, M; Chojnowska, K; Kurzyńska, A | 2 |
| Arankowsky-Sandoval, G; Arias-Carrión, O; Guzmán, K; Mijangos-Moreno, S; Murillo-Rodríguez, E; Poot-Aké, A; Sarro-Ramírez, A; Zaldívar-Rae, J | 1 |
| Arankowsky-Sandoval, G; Arias-Carrión, O; Guzmán, K; Jiménez-Moreno, R; Murillo-Rodríguez, E; Salas-Crisóstomo, M | 1 |
21 other study(ies) available for pirinixic acid and l 663536
| Article | Year |
|---|---|
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Topics: Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Cyclooxygenase 1; Cyclooxygenase 2; Drug Design; Enzyme Activation; Enzyme Inhibitors; Humans; Inflammation; Inhibitory Concentration 50; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Models, Chemical; Prostaglandin-E Synthases; Pyrimidines | 2008 |
A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold.
Topics: Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Inhibitory Concentration 50; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Models, Biological; Molecular Structure; Naphthols; Prostaglandin-E Synthases; Pyrimidines; Structure-Activity Relationship | 2011 |
Potentiation of TNF-alpha-stimulated group IIA phospholipase A(2) expression by peroxisome proliferator-activated receptor alpha activators in rat mesangial cells.
Topics: Acetophenones; Animals; Binding Sites; Cells, Cultured; Drug Synergism; Gene Deletion; Glomerular Mesangium; Group II Phospholipases A2; Indoles; Kidney; Peroxisome Proliferators; Phospholipases A; Point Mutation; Promoter Regions, Genetic; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tetrazoles; Transcription Factors; Tumor Necrosis Factor-alpha | 2002 |
Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886.
Topics: Acute-Phase Proteins; Animals; Apoptosis; Carcinogens; Caspase 3; Caspases; Gene Expression Regulation; Indoles; Lipocalin-2; Lipocalins; Lipoxygenase Inhibitors; Mice; Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Thiazoles; Thiazolidinediones | 2003 |
Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition.
Topics: Acetophenones; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arachidonic Acid; Caspases; Cell Growth Processes; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Indoles; Isotretinoin; Ligands; Lung Neoplasms; Peroxisome Proliferator-Activated Receptors; Prostaglandin D2; Pyrimidines; Retinoid X Receptor alpha; RNA, Messenger; Tetrazoles; Thiazolidinediones | 2005 |
The peroxisome proliferator-activated receptor alpha activator, Wy14,643, is anti-inflammatory in vivo.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Ear, External; Edema; Female; Indoles; Indomethacin; Inflammation; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Neutrophils; Palmitoyl Coenzyme A; Peroxisomes; PPAR alpha; Prostaglandin-Endoperoxide Synthases; Pyrimidines | 2005 |
Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Cardiovascular Agents; Cell Line; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gynostemma; Humans; Indoles; Lipopolysaccharides; Monocytes; NF-kappa B; Peroxisome Proliferators; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Pyrrolidines; RNA, Messenger; Saponins; Thiocarbamates; Thromboplastin; Transcription, Genetic; Transfection | 2007 |
Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress.
Topics: Animals; Cell Line, Transformed; Cell Survival; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Gene Silencing; Glutathione; Indoles; Ion Channels; Mitochondria; Mitochondrial Proteins; Neurons; Oxidative Stress; Potassium Cyanide; PPAR alpha; Pyrimidines; Rats; Reactive Oxygen Species; Uncoupling Protein 2; Up-Regulation; Vitamin E | 2007 |
Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism.
Topics: Animals; Butyrates; Cell Differentiation; Cells, Cultured; Clofibric Acid; Embryonic Stem Cells; Enzyme Inhibitors; Fibric Acids; Free Radical Scavengers; Gene Expression; Gene Expression Regulation, Developmental; Heart; Immunohistochemistry; Indoles; Mice; Myocytes, Cardiac; NADPH Oxidases; Peroxisome Proliferators; Phenylurea Compounds; PPAR alpha; PPAR gamma; PPAR-beta; Pyrimidines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
In vivo imaging reveals selective peroxisome proliferator activated receptor modulator activity of the synthetic ligand 3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886).
Topics: Animals; Drug Evaluation, Preclinical; Gene Expression Regulation; Genes, Reporter; Indoles; Ligands; Luciferases; Lung; Male; Mice; Mice, Transgenic; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR gamma; Pyrimidines; Response Elements; Signal Transduction; Testis; Time Factors; Tissue Distribution; Whole Body Imaging | 2008 |
Down-regulation of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARalpha.
Topics: Animals; Carboxy-Lyases; Cells, Cultured; Dietary Fats, Unsaturated; Eicosapentaenoic Acid; Enzyme Repression; Fatty Acids, Unsaturated; Hepatocytes; Indoles; Linoleic Acid; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Exocytosis; Gastric Mucosa; Guinea Pigs; Indoles; Indomethacin; Male; PPAR alpha; Pyloric Antrum; Pyrimidines; Thapsigargin | 2010 |
Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.
Topics: Action Potentials; Animals; Behavior, Animal; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Indoles; Male; Microdialysis; Neurons; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Oligosaccharides; Peroxisome Proliferators; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Saimiri; Self Administration; Ventral Tegmental Area | 2011 |
20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-α in vascular smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cyclooxygenase 2; Hydroxyeicosatetraenoic Acids; Indoles; Luciferases; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Rats; RNA, Small Interfering; Transcription Factor AP-1 | 2011 |
Peroxisome proliferator-activated receptor-alpha agonists repress expression of thrombin-activatable fibrinolysis inhibitor by decreasing transcript stability.
Topics: Carboxypeptidase B; Carboxypeptidase B2; Cell Line, Tumor; Fibrinolysis; Gene Expression Regulation; Hep G2 Cells; Humans; Indoles; PPAR alpha; PPAR gamma; PPAR-beta; Pyrimidines; RNA Precursors; RNA Stability; RNA, Messenger; RNA, Small Interfering; Transcription, Genetic | 2012 |
Attenuation of acute pancreatitis by peroxisome proliferator-activated receptor-α in rats: the effect on Toll-like receptor signaling pathways.
Topics: Amylases; Animals; Anti-Inflammatory Agents; Biomarkers; Blotting, Western; Calcium; Ceruletide; Cytokines; Disease Models, Animal; Gene Expression Regulation; Indoles; Intercellular Adhesion Molecule-1; Lipase; Male; Neutrophil Infiltration; Pancreas; Pancreatitis; Peroxidase; PPAR alpha; Pyrimidines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptor 9; Toll-Like Receptors | 2013 |
In vitro effect of peroxisome proliferator activated receptor (PPAR) ligands on prostaglandin E2 synthesis and secretion by porcine endometrium during the estrous cycle and early pregnancy.
Topics: Animals; Dinoprostone; Endometrium; Estrous Cycle; Female; Indoles; Intramolecular Oxidoreductases; Ligands; Peroxisome Proliferator-Activated Receptors; Phenoxyacetates; Pregnancy; Prostaglandin-E Synthases; Pyrimidines; RNA, Messenger; Rosiglitazone; Swine; Thiazolidinediones | 2013 |
The involvement of peroxisome proliferator activated receptors (PPARs) in prostaglandin F2α production by porcine endometrium.
Topics: Analysis of Variance; Anilides; Animals; Benzamides; Culture Media; Dinoprost; DNA Primers; Endometrium; Estrous Cycle; Female; Indoles; Peroxisome Proliferator-Activated Receptors; Phenoxyacetates; Pregnancy; Prostaglandin D2; Pyridines; Pyrimidines; Radioimmunoassay; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Rosiglitazone; Swine; Thiazolidinediones | 2013 |
Peroxisome proliferator activated receptor ligands affect progesterone and 17β-estradiol secretion by porcine corpus luteum during early pregnancy.
Topics: 3-Hydroxysteroid Dehydrogenases; Anilides; Animals; Benzamides; Corpus Luteum; Estradiol; Estrous Cycle; Female; Gene Expression; Indoles; Ligands; Peroxisome Proliferator-Activated Receptors; Phenoxyacetates; Pregnancy; Progesterone; Prostaglandin D2; Pyridines; Pyrimidines; RNA, Messenger; Rosiglitazone; Swine; Thiazolidinediones | 2014 |
Sleep and neurochemical modulation by the nuclear peroxisome proliferator-activated receptor α (PPAR-α) in rat.
Topics: Adenosine; Animals; Biogenic Monoamines; Dopamine; Indoles; Male; Norepinephrine; Nucleus Accumbens; PPAR alpha; Pyrimidines; Rats, Wistar; Serotonin; Sleep; Sleep Stages | 2016 |
Evidence that activation of nuclear peroxisome proliferator-activated receptor alpha (PPARα) modulates sleep homeostasis in rats.
Topics: Adenosine; Animals; Biogenic Monoamines; Brain; Dose-Response Relationship, Drug; Endocannabinoids; Homeostasis; Indoles; Male; Oleic Acids; Peroxisome Proliferators; PPAR alpha; Pyrimidines; Rats, Wistar; Sleep; Sleep Deprivation; Wakefulness; Wakefulness-Promoting Agents | 2016 |