pirinixic acid has been researched along with gemfibrozil in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (29.17) | 18.2507 |
| 2000's | 13 (54.17) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Cattley, RC; Miller, RT; Sausen, PJ; Teets, VJ; Voss, KS | 1 |
| Chinetti, G; Delerive, P; Fadel, A; Fruchart, JC; Habib, A; Koenig, W; Lebret, M; Maclouf, J; Merval, R; Najib, J; Staels, B; Tedgui, A; Torra, IP | 1 |
| Cattley, RC; Corton, JC; Fan, LQ | 1 |
| Kockx, M; Kooistra, T; Princen, HM | 1 |
| Wallace, KB; Zhou, S | 1 |
| Eriksson, P; Hamsten, A; Nilsson, L; Takemura, T | 1 |
| Baugé, E; Chinetti, G; Clavey, V; Copin, C; Dallongeville, J; Fruchart, J; Fruchart, JC; Mariotte, MC; Staels, B | 1 |
| Asakawa, M; Komuro, I; Masuda, Y; Nagai, T; Oka, T; Saito, T; Takano, H; Toyozaki, T | 1 |
| Cunningham, ML; Glauert, HP; O'Brien, ML; Spear, BT | 1 |
| Cunningham, ML; Glauert, HP; O'Brien, ML; Spear, BT; Twaroski, TP | 1 |
| Cunningham, ML; Glauert, HP; Spear, BT; Tharappel, JC | 1 |
| Alexson, SE; Bridgers, K; Corton, JC; Poole, M | 1 |
| Dilley, RJ; Little, PJ; Nigro, J | 1 |
| Afshari, CA; Barrett, JC; Bennett, L; Blanchard, K; Bushel, PR; DiSorbo, O; Hamadeh, HK; Jayadev, S; Martin, K; Paules, RS; Sieber, S; Stoll, R; Tennant, R | 1 |
| Agellon, LB; Gbaguidi, GF | 1 |
| Baldwin, GS; Ford, J; Lachal, S; Shulkes, A | 1 |
| Brown, S; Brown-Borg, H; Corton, JC; Fan, LQ; Mode, A; Westin, S | 1 |
| Lee, LE; Liu, G; Metcalfe, CD; Moon, TW; Trudeau, VL | 1 |
| Miyagishima, T; Nagao, T; Ono, A; Tamura, K; Urushidani, T | 1 |
| Hashimoto, F; Hayashi, H; Iwasaki, K; Morita, M; Takeda, S | 1 |
24 other study(ies) available for pirinixic acid and gemfibrozil
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Gemfibrozil-induced peroxisome proliferation and hepatomegaly in male F344 rats.
Topics: Animals; Cell Division; Gemfibrozil; Hepatomegaly; Humans; Hypolipidemic Agents; Male; Microbodies; Pyrimidines; Rats; Rats, Inbred F344 | 1995 |
Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators.
Topics: Acute-Phase Proteins; Animals; Anti-Inflammatory Agents; Aorta; Coronary Disease; COS Cells; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fenofibrate; Gemfibrozil; Gene Expression Regulation, Enzymologic; Humans; Hyperlipidemias; Hypolipidemic Agents; Inflammation; Interleukin-1; Interleukin-6; Isoenzymes; Membrane Proteins; Muscle, Smooth, Vascular; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic | 1998 |
Tissue-specific induction of 17 beta-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated receptor alpha.
Topics: 17-Hydroxysteroid Dehydrogenases; Administration, Topical; Animals; Anti-Inflammatory Agents; Blotting, Northern; Blotting, Western; Cells, Cultured; Dibutyl Phthalate; Dimethyl Sulfoxide; Enzyme Induction; Gemfibrozil; Isoenzymes; Kidney; Liver; Male; Microbodies; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 1998 |
Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Alitretinoin; Animals; Apolipoprotein A-I; Cells, Cultured; Clofibrate; Clofibric Acid; Dimerization; Female; Fenofibrate; Fibric Acids; Fibrinogen; Gemfibrozil; Gene Expression Regulation; Genes, Reporter; Hypolipidemic Agents; Liver; Macaca fascicularis; Male; Peroxisome Proliferators; Plasminogen Activator Inhibitor 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Transcriptional Activation; Tretinoin | 1998 |
The effect of peroxisome proliferators on mitochondrial bioenergetics.
Topics: Animals; Bezafibrate; Calcium; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Energy Metabolism; Fenofibrate; Fibric Acids; Gemfibrozil; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Oxygen; Permeability; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Trichloroethylene | 1999 |
Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells.
Topics: Bezafibrate; Cells, Cultured; Clofibric Acid; Endothelium, Vascular; Fenofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Plasminogen Activator Inhibitor 1; Pyrimidines; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription, Genetic | 1999 |
Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma HepG2 cells.
Topics: Animals; Anticholesteremic Agents; Apolipoprotein C-III; Apolipoproteins; Apolipoproteins C; Blood; Carcinoma, Hepatocellular; Cattle; Culture Media; DNA-Binding Proteins; Fenofibrate; Gemfibrozil; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Kinetics; Liver Neoplasms; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
Peroxisome proliferator-activated receptor activators inhibit lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes.
Topics: Animals; Cell Nucleus; Cells, Cultured; Chromans; Drug Interactions; Gemfibrozil; Hypoglycemic Agents; Lipopolysaccharides; Myocardium; NF-kappa B; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Necrosis Factor-alpha | 2000 |
Effects of peroxisome proliferators on glutathione and glutathione-related enzymes in rats and hamsters.
Topics: Animals; Cricetinae; Dibutyl Phthalate; Gemfibrozil; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hydrogen Peroxide; Male; Mesocricetus; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Species Specificity | 2001 |
Effects of peroxisome proliferators on antioxidant enzymes and antioxidant vitamins in rats and hamsters.
Topics: Animals; Antioxidants; Ascorbic Acid; Cricetinae; Dibutyl Phthalate; Gemfibrozil; Liver; Male; Mesocricetus; NAD(P)H Dehydrogenase (Quinone); Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Species Specificity; Superoxide Dismutase; Vitamin E | 2001 |
Differential activation of hepatic NF-kappaB in rats and hamsters by the peroxisome proliferators Wy-14,643, gemfibrozil, and dibutyl phthalate.
Topics: Animals; Cricetinae; Dibutyl Phthalate; DNA; DNA-Binding Proteins; Electrophoresis; Gemfibrozil; Liver; Male; Mesocricetus; NF-kappa B; Oligonucleotide Probes; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Time Factors | 2001 |
Altered expression of the carboxylesterases ES-4 and ES-10 by peroxisome proliferator chemicals.
Topics: Animals; Blotting, Western; Carboxylesterase; Carboxylic Ester Hydrolases; Dibutyl Phthalate; Dose-Response Relationship, Drug; Down-Regulation; Female; Gemfibrozil; Kinetics; Liver; Male; Mice; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sex Factors; Species Specificity; Transcription Factors | 2001 |
Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells.
Topics: Cell Division; Cell Movement; DNA; Dose-Response Relationship, Drug; Drug Evaluation; Gemfibrozil; Glucose; Glycosaminoglycans; Glycosides; Humans; Hypolipidemic Agents; Muscle, Smooth, Vascular; Proteoglycans; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Treatment Outcome | 2002 |
Gene expression analysis reveals chemical-specific profiles.
Topics: Animals; Clofibrate; Computational Biology; DNA, Complementary; Gemfibrozil; Gene Expression; Gene Expression Profiling; Genomics; Liver; Male; Oligonucleotide Array Sequence Analysis; Pattern Recognition, Automated; Peroxisome Proliferators; Phenobarbital; Pyrimidines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2002 |
The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer.
Topics: Acids, Acyclic; Animals; Bezafibrate; Binding Sites; Cell Line, Tumor; Cells, Cultured; Cholesterol 7-alpha-Hydroxylase; Clofibrate; Dimerization; DNA-Binding Proteins; Gemfibrozil; Gene Expression Regulation; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Hydroxycholesterols; Ligands; Liver X Receptors; Nuclear Proteins; Orphan Nuclear Receptors; Promoter Regions, Genetic; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Repetitive Sequences, Nucleic Acid; Response Elements; Transcription Factors | 2004 |
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.
Topics: Bezafibrate; Cell Proliferation; Clofibrate; Clofibric Acid; Colorectal Neoplasms; Fenofibrate; Fibric Acids; Gastrins; Gemfibrozil; Humans; Hypolipidemic Agents; Ligands; Peroxisome Proliferator-Activated Receptors; Protein Precursors; Pyrimidines; Radioimmunoassay; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Vasodilator Agents | 2004 |
PPARalpha activators down-regulate CYP2C7, a retinoic acid and testosterone hydroxylase.
Topics: Animals; Antibodies, Blocking; Biotransformation; Blotting, Northern; Blotting, Western; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dibutyl Phthalate; Down-Regulation; Female; Gemfibrozil; Liver; Male; Peroxisome Proliferator-Activated Receptors; Pyrimidines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Sex Characteristics | 2004 |
A teleost in vitro reporter gene assay to screen for agonists of the peroxisome proliferator-activated receptors.
Topics: Acetyl-CoA C-Acyltransferase; Alitretinoin; Angiogenesis Inhibitors; Animals; Bezafibrate; Cloning, Molecular; DNA; DNA, Complementary; Dose-Response Relationship, Drug; Environmental Monitoring; Gemfibrozil; Genes, Reporter; Humans; Hypolipidemic Agents; In Vitro Techniques; Liver; Luciferases; Oncorhynchus mykiss; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Plasmids; PPAR alpha; PPAR-beta; Promoter Regions, Genetic; Pyrimidines; Rats; Retinoid X Receptors; Transcription, Genetic; Transfection; Tretinoin; Water Pollutants, Chemical | 2005 |
Profiling of gene expression in rat liver and rat primary cultured hepatocytes treated with peroxisome proliferators.
Topics: Alanine Transaminase; Animals; Cells, Cultured; Clofibrate; Cluster Analysis; Databases, Factual; Gemfibrozil; Gene Expression Profiling; Gene Expression Regulation; Hepatocytes; Liver; Male; Oligonucleotide Array Sequence Analysis; Peroxisome Proliferators; PPAR alpha; Principal Component Analysis; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Triglycerides | 2006 |
Effects of WY-14643 on peroxisomal enzyme activity and hormone secretion in immortalized human trophoblast cells.
Topics: Acyl-CoA Oxidase; Catalase; Cell Culture Techniques; Cell Line; Centrifugation, Density Gradient; Chorionic Gonadotropin; Clofibric Acid; Gemfibrozil; Hormones; Humans; Peroxisome Proliferators; Peroxisomes; Progesterone; Pyrimidines; Trophoblasts | 2009 |