pirinixic acid has been researched along with fenofibrate in 64 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (14.06) | 18.2507 |
| 2000's | 30 (46.88) | 29.6817 |
| 2010's | 22 (34.38) | 24.3611 |
| 2020's | 3 (4.69) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, PJ; Henke, BR; Sternbach, DD; Willson, TM | 1 |
| Gavande, N; Hanrahan, JR; Hibbs, DE; Kim, MS; Matin, A; Roubin, RH; Salam, NK; Yang, NX | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Altieri, F; Azzariti, A; Cervoni, L; Crestani, M; Di Giovanni, C; Fracchiolla, G; Gilardi, F; Giudici, M; Guerrini, U; Laghezza, A; Lavecchia, A; Loiodice, F; Mitro, N; Montanari, R; Paradiso, A; Piemontese, L; Pochetti, G; Porcelli, L; Simone, GM; Tortorella, P | 1 |
| Doddareddy, MR; Gavande, N; Groundwater, PW; Hibbs, DE; Matin, A; Nammi, S; Roubin, RH | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Balaban, S; Cairns, R; Gao, Q; Grewal, T; Groundwater, PW; Hanh, J; Hibbs, DE; Hoy, AJ; Lai, F; Liao, VW; Lin, HY; Ong, JA; Sjöström, H; Váradi, L; Wood, P | 1 |
| Brunetti, L; Cerchia, C; Genovese, M; Gilardi, F; Laghezza, A; Lavecchia, A; Leuci, R; Loiodice, F; Paoli, P; Piemontese, L; Santi, A; Sblano, S; Thomas, A; Tortorella, P | 1 |
| Auwerx, J; Dallongeville, J; Fruchart, JC; Kosykh, V; Schoonjans, K; Staels, B; Vu-Dac, N | 1 |
| Chinetti, G; Delerive, P; Fadel, A; Fruchart, JC; Habib, A; Koenig, W; Lebret, M; Maclouf, J; Merval, R; Najib, J; Staels, B; Tedgui, A; Torra, IP | 1 |
| Kockx, M; Kooistra, T; Princen, HM | 1 |
| Chopin-Delannoy, S; Dubois, G; Fadel, A; Fruchart, JC; Gervois, P; Kosykh, V; Laudet, V; Najïb, J; Staels, B | 1 |
| Wallace, KB; Zhou, S | 1 |
| Eriksson, P; Hamsten, A; Nilsson, L; Takemura, T | 1 |
| Collins, T; Libby, P; Marx, N; Plutzky, J; Sukhova, GK | 1 |
| Clarke, S; Gimble, JM; Gonzalez, FJ; Hill, MR; Peters, JM; Rodgers, K; Thornhill, B | 1 |
| Baugé, E; Chinetti, G; Clavey, V; Copin, C; Dallongeville, J; Fruchart, J; Fruchart, JC; Mariotte, MC; Staels, B | 1 |
| Chao, YS; Chen, Y; Doebber, T; Elbrecht, A; Gerhold, D; Guo, Q; Hermanowski-Vosatka, A; Ippolito, M; Kelly, L; Loving, VA; Lu, M; Milot, D; Mundt, SS; Thieringer, R; Wang, PR; Wright, SD; Wu, M | 1 |
| Chinetti, G; Corseaux, D; Duriez, P; Fruchart, JC; Jude, B; Neve, BP; Staels, B; Zawadzki, C | 1 |
| Ezaki, O; Miura, S; Nakatani, T; Takahashi, M; Tsuboyama-Kasaoka, N | 1 |
| Kuromitsu, J; Tanaka, I; Yamazaki, K | 1 |
| Grüb, M; Hombach, V; Kehrle, B; Koenig, W; Kohlhammer, K; Libby, P; Marx, N; Plutzky, J | 1 |
| Blaschke, F; Bungenstock, A; Eilers, F; Fleck, E; Goetze, S; Graf, K; Gräfe, M; Kintscher, U; Law, RE; Stawowy, P | 1 |
| Bauge, E; Dehondt, H; Fruchart, JC; Fruchart-Najib, J; Gervois, P; Jakel, H; Nowak, M; Pennacchio, LA; Rubin, EM; Staels, B; Vu-Dac, N | 1 |
| Fleckner, J; Frederiksen, KS; Sauerberg, P; Wassermann, K; Wulf, EM | 1 |
| Gardner, DG; Liang, F; Wang, F; Zhang, S | 1 |
| Cha, BS; Kim, NH; Kim, YS; Lee, GY; Zhao, ZS | 1 |
| Gille, J; Kaufmann, R; Meissner, M; Reisinger, K; Staels, B; Stein, M; Suske, G; Urbich, C | 1 |
| Goya, K; Kasayama, S; Kawase, I; Kitamura, T; Kouhara, H; Kurebayashi, S; Saito, H; Sumitani, S; Xu, X; Yamamoto, H | 1 |
| Kong, JY; Rabkin, SW | 1 |
| Benéteau, N; Chapuis, V; Colpaert, FC; Dupont-Passelaigue, E; Junquéro, D; Lestienne, F; Patoiseau, JF; Rival, Y; Taillandier, T | 1 |
| Baldwin, GS; Ford, J; Lachal, S; Shulkes, A | 1 |
| Harano, Y; Itoh, Y; Kirishima, T; Minami, M; Morita, A; Nakamura, H; Okanoue, T; Toyama, T; Yamauchi, N | 1 |
| Haas, C; Häring, HU; Kaltenbach, S; Machicao, F; Staiger, H; Stumvoll, M; Weisser, M | 1 |
| Capdevila, JH; Falck, JR; Lavrentyev, EN; Malik, KU; Parmentier, JH | 1 |
| Asai, T; Cao, X; Hirai, T; Kambe, F; Murakami, H; Murakami, R; Murohara, T; Numaguchi, Y; Okumura, K; Seo, H; Takahashi, R | 1 |
| Caguyong, MJ; Cornwell, PD; Dai, X; De Souza, AT; Ulrich, RG | 1 |
| Essop, MF; Felix, R; Zungu, M | 1 |
| Yamashita, M | 1 |
| Blann, E; Collins, J; Dial, S; Dragan, YP; Fan, XH; Fang, H; Guo, L; Mehta, K; Shi, L; Tong, W; Wong, A | 1 |
| Binder, BR; Blüml, S; Bochkov, VN; Exner, M; Fürnkranz, A; Ikonomu, E; Kadl, A; Krönke, G; Leitinger, N; Sarembock, IJ | 1 |
| Carissimi, R; Galli, C; Ghezzi, S; Mastromauro, F; Petroni, A; Risé, P | 1 |
| Banks, T; Oyekan, A | 1 |
| Kamei, Y; Kato, H; Ogawa, Y; Suganami, T; Sugita, S; Takeya, M; Toyoda, T | 1 |
| Chanda, D; Chiang, JY; Choi, HS; Hwang, JH; Jeong, KH; Kim, DK; Kim, YH; Kweon, GR; Lee, CH; Lee, IK; Lee, MR; Noh, JR; Oh, GT; Park, JH; Shong, M | 1 |
| Gelebart, P; Lai, R; Zak, Z | 1 |
| Ahn, JH; Bae, MA; Cho, YS; Kim, CH; Ramu, R | 1 |
| Abe, M; Aihara, K; Akaike, M; Azuma, H; Hashizume, S; Ikeda, Y; Ishikawa, K; Iwase, T; Matsumoto, T; Sata, M; Sumitomo-Ueda, Y; Yagi, S; Yoshida, S | 1 |
| Namura, S; Wang, G | 1 |
| Amann, T; Bauer, S; Buechler, C; Eisinger, K; Hellerbrand, C; Neumeier, M; Schäffler, A; Schölmerich, J; Walter, R; Wanninger, J; Weiss, TS | 1 |
| Asavapanumas, N; Chatsudthipong, V; Kittayaruksakul, S; Meetam, P; Muanprasat, C; Soodvilai, S | 1 |
| Leung, SW; Man, RY; Qu, C; Vanhoutte, PM | 1 |
| Aroni, S; Carta, G; De Montis, MG; Lecca, S; Marrosu, F; Melis, M; Muntoni, AL; Murru, E; Pillolla, G; Pistis, M; Puligheddu, M; Scheggi, S | 1 |
| Barbier, O; Caron, P; Dallaire-Theroux, A; Levy, C; Perreault, M; Rudkowska, I; Staels, B; Straka, RJ; Trottier, J; Verreault, M; Vohl, MC | 1 |
| Ghanem, SS; Heinrich, G; Najjar, SM; Oyarce, AM; Patel, PR; Ramakrishnan, SK; Russo, L | 1 |
| Han, SI; Iwasaki, H; Matsuzaka, T; Murayama, Y; Nakagawa, Y; Ohno, H; Oikawa, F; Osaki, Y; Satoh, A; Sekiya, M; Shimano, H; Suzuki, H; Takei, K; Yahagi, N; Yamada, N; Yatoh, S | 1 |
| Bagdas, D; Carroll, FI; Damaj, MI; Greenwald, M; Jackson, A; Lichtman, AH; Miles, MF; Muldoon, PP | 1 |
| Cheng, Y; Dai, M; Gonzalez, FJ; Guo, B; Hua, H; Lin, H; Lin, J; Liu, A; Luo, M; Song, D; Xie, M; Xu, G; Yang, J; Zhao, J | 1 |
| Chen, H; Leung, SWS; Man, RYK | 1 |
| Angelucci, A; Arcella, A; Beckers, A; Colapietro, A; Esposito, V; Giangaspero, F; Jaffrain-Rea, ML; Morace, R; Polidoro, MA; Rostomyan, L; Rotondi, S; Ventura, L | 1 |
| Amagase, Y; Mizukawa, Y; Urushidani, T | 2 |
1 review(s) available for pirinixic acid and fenofibrate
| Article | Year |
|---|---|
The PPARs: from orphan receptors to drug discovery.
Topics: Animals; Diabetes Mellitus; Drug Design; Humans; Hyperlipidemias; Hypertension; Inflammation; Ligands; Models, Molecular; Neoplasms; Nuclear Proteins; Obesity; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2000 |
2 trial(s) available for pirinixic acid and fenofibrate
| Article | Year |
|---|---|
Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Apolipoprotein A-II; Apolipoproteins E; Base Sequence; Cells, Cultured; Cholesterol, HDL; Coronary Disease; Fenofibrate; Gene Expression Regulation; Genes, Reporter; Hepatoblastoma; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1995 |
Profiling serum bile acid glucuronides in humans: gender divergences, genetic determinants, and response to fenofibrate.
Topics: Bile Acids and Salts; Cholestasis; Female; Fenofibrate; Gene Expression Regulation; Glucuronides; Glucuronosyltransferase; Humans; Hypolipidemic Agents; Male; Microsomes, Liver; Peroxisome Proliferators; Polymorphism, Genetic; PPAR alpha; Pyrimidines; Sex Characteristics | 2013 |
61 other study(ies) available for pirinixic acid and fenofibrate
| Article | Year |
|---|---|
7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.
Topics: Benzopyrans; Cell Line; Humans; PPAR alpha; PPAR gamma; Structure-Activity Relationship | 2009 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
Topics: Adipocytes; Animals; Antineoplastic Agents; Benzoxazoles; Body Weight; Calorimetry; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Partial Agonism; Drug Screening Assays, Antitumor; Fibric Acids; Fibroblasts; Gene Expression Profiling; Humans; Insulin Resistance; Intra-Abdominal Fat; Liver; Mice; Mice, Inbred C57BL; Models, Molecular; PPAR alpha; PPAR gamma; Propionates; Stereoisomerism; Structure-Activity Relationship; Urea | 2012 |
The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.
Topics: Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Isoflavones; Models, Molecular; Molecular Structure; Peroxisome Proliferator-Activated Receptors; Structure-Activity Relationship | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Identification of dual PPARα/γ agonists and their effects on lipid metabolism.
Topics: 3T3-L1 Cells; Animals; Cell Line; Diabetes Mellitus, Type 2; Drug Design; HEK293 Cells; Humans; Ligands; Lipid Metabolism; Mice; Molecular Docking Simulation; PPAR alpha; PPAR gamma; Small Molecule Libraries | 2015 |
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity.
Topics: Cheminformatics; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Ligands; Lipids; Peroxisome Proliferator-Activated Receptors; PPAR gamma | 2022 |
Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators.
Topics: Acute-Phase Proteins; Animals; Anti-Inflammatory Agents; Aorta; Coronary Disease; COS Cells; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fenofibrate; Gemfibrozil; Gene Expression Regulation, Enzymologic; Humans; Hyperlipidemias; Hypolipidemic Agents; Inflammation; Interleukin-1; Interleukin-6; Isoenzymes; Membrane Proteins; Muscle, Smooth, Vascular; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic | 1998 |
Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Alitretinoin; Animals; Apolipoprotein A-I; Cells, Cultured; Clofibrate; Clofibric Acid; Dimerization; Female; Fenofibrate; Fibric Acids; Fibrinogen; Gemfibrozil; Gene Expression Regulation; Genes, Reporter; Hypolipidemic Agents; Liver; Macaca fascicularis; Male; Peroxisome Proliferators; Plasminogen Activator Inhibitor 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Transcriptional Activation; Tretinoin | 1998 |
Fibrates increase human REV-ERBalpha expression in liver via a novel peroxisome proliferator-activated receptor response element.
Topics: Binding Sites; Dimerization; DNA-Binding Proteins; Fenofibrate; Gene Expression Regulation; Humans; Hypolipidemic Agents; Liver; Nuclear Receptor Subfamily 1, Group D, Member 1; Peroxisome Proliferators; Promoter Regions, Genetic; Proteins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Response Elements; Retinoid X Receptors; RNA, Messenger; Transcription Factors | 1999 |
The effect of peroxisome proliferators on mitochondrial bioenergetics.
Topics: Animals; Bezafibrate; Calcium; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Energy Metabolism; Fenofibrate; Fibric Acids; Gemfibrozil; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Oxygen; Permeability; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Trichloroethylene | 1999 |
Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells.
Topics: Bezafibrate; Cells, Cultured; Clofibric Acid; Endothelium, Vascular; Fenofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Plasminogen Activator Inhibitor 1; Pyrimidines; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription, Genetic | 1999 |
PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells.
Topics: Anticholesteremic Agents; Arteriosclerosis; Carotid Arteries; Cell Adhesion; Dose-Response Relationship, Drug; Endothelium, Vascular; Fenofibrate; Gene Expression; Humans; Hypolipidemic Agents; Monocytes; NF-kappa B; Promoter Regions, Genetic; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Saphenous Vein; Transcription Factors; Transfection; Tumor Necrosis Factor-alpha; U937 Cells; Vascular Cell Adhesion Molecule-1 | 1999 |
Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia.
Topics: Animals; Endotoxemia; Fenofibrate; Humans; Hypolipidemic Agents; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Knockout; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Tumor Necrosis Factor-alpha | 1999 |
Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma HepG2 cells.
Topics: Animals; Anticholesteremic Agents; Apolipoprotein C-III; Apolipoproteins; Apolipoproteins C; Blood; Carcinoma, Hepatocellular; Cattle; Culture Media; DNA-Binding Proteins; Fenofibrate; Gemfibrozil; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Kinetics; Liver Neoplasms; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Animals; Cells, Cultured; Cricetinae; DNA-Binding Proteins; Feedback; Fenofibrate; Gene Expression Regulation, Enzymologic; Hepatocytes; Hydroxysteroid Dehydrogenases; Liver; Mice; Mice, Knockout; Models, Biological; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2000 |
PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages.
Topics: Butyrates; Cells, Cultured; Down-Regulation; Fenofibrate; Humans; Interleukin-1; Lipopolysaccharides; Macrophages; Monocytes; Peroxisome Proliferators; Phenylurea Compounds; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thromboplastin; Transcription Factors | 2001 |
Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes.
Topics: Animals; Cells, Cultured; Female; Fenofibrate; Fish Oils; Gene Expression Regulation; Hepatocytes; Ion Channels; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Proteins; Pyrimidines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; RNA, Messenger; Transcription Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha; Uncoupling Protein 2; Up-Regulation | 2002 |
Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator- activated receptor alpha agonists.
Topics: Acute-Phase Reaction; Animals; Down-Regulation; Fenofibrate; Gene Expression Profiling; Liver; Metallothionein; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Serum Amyloid A Protein; Transcription Factors | 2002 |
PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis.
Topics: Anti-Inflammatory Agents; Arteriosclerosis; CD4-Positive T-Lymphocytes; Cells, Cultured; Fenofibrate; Graft Survival; Heart Transplantation; Humans; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Peroxisome Proliferators; Pioglitazone; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha | 2002 |
PPAR activators inhibit endothelial cell migration by targeting Akt.
Topics: Apoptosis; Blotting, Western; Cell Movement; Cells, Cultured; Chromans; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Fenofibrate; Flavonoids; Humans; Hypoglycemic Agents; Hypolipidemic Agents; In Situ Nick-End Labeling; Lipid Metabolism; Lymphokines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peroxisome Proliferators; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasodilator Agents | 2002 |
Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators.
Topics: Apolipoprotein A-V; Apolipoproteins; Apolipoproteins A; Base Sequence; Cells, Cultured; Cloning, Molecular; Fenofibrate; Gene Expression Regulation; Hepatocytes; Humans; Hypolipidemic Agents; Luciferases; Molecular Sequence Data; Peroxisome Proliferators; Promoter Regions, Genetic; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Response Elements; Transcription Factors; Transcription, Genetic; Transfection; Triglycerides | 2003 |
Identification of hepatic transcriptional changes in insulin-resistant rats treated with peroxisome proliferator activated receptor-alpha agonists.
Topics: Animals; Blotting, Western; Fenofibrate; Insulin Resistance; Liver; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transcription, Genetic | 2003 |
Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes.
Topics: Animals; Animals, Newborn; Base Sequence; Cell Size; Cells, Cultured; Fenofibrate; Gene Expression; Heart Ventricles; Hypertrophy; Hypoglycemic Agents; Hypolipidemic Agents; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Myocytes, Cardiac; Natriuretic Peptide, Brain; Peroxisome Proliferators; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Sarcomeres; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level.
Topics: Animals; Base Sequence; Binding Sites; Carboxy-Lyases; Cell Line; Cell Line, Tumor; Fenofibrate; Gene Expression Regulation, Enzymologic; Liver; Malonyl Coenzyme A; Molecular Sequence Data; Promoter Regions, Genetic; Pyrimidines; Rats; Rats, Inbred OLETF; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Response Elements; Retinoid X Receptors; RNA, Messenger; Transcription Factors; Transcriptional Activation; Triglycerides | 2004 |
PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation.
Topics: Binding Sites; Cell Division; Cells, Cultured; Endothelial Cells; Fenofibrate; Gene Expression Regulation; Humans; Luciferases; Neovascularization, Physiologic; Peroxisome Proliferators; Promoter Regions, Genetic; Protein Binding; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; RNA, Messenger; Rosiglitazone; Sp1 Transcription Factor; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2004 |
Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells.
Topics: Animals; Aorta; Bezafibrate; Cattle; Cells, Cultured; Dactinomycin; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Fenofibrate; Gene Expression Regulation, Enzymologic; Half-Life; Mifepristone; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection | 2004 |
Reduction of palmitate-induced cardiac apoptosis by fenofibrate.
Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Apoptosis; Cell Survival; Cells, Cultured; Chick Embryo; Drug Antagonism; Fenofibrate; Gene Expression Regulation; Hypolipidemic Agents; Mice; Myocytes, Cardiac; Palmitates; Pyrimidines | 2004 |
Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages.
Topics: Acetamides; Acetates; Anilides; Cardiovascular Agents; Cell Line; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fenofibrate; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins, LDL; Macrophages; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mevalonic Acid; Monocytes; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Sterol O-Acyltransferase; Sulfonamides; Sulfonic Acids; Tetradecanoylphorbol Acetate; Thiazolidinediones; Tissue Inhibitor of Metalloproteinase-1; Transcription Factors | 2004 |
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.
Topics: Bezafibrate; Cell Proliferation; Clofibrate; Clofibric Acid; Colorectal Neoplasms; Fenofibrate; Fibric Acids; Gastrins; Gemfibrozil; Humans; Hypolipidemic Agents; Ligands; Peroxisome Proliferator-Activated Receptors; Protein Precursors; Pyrimidines; Radioimmunoassay; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Vasodilator Agents | 2004 |
PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats.
Topics: Animals; Antioxidants; Blotting, Northern; Catalase; Densitometry; Fenofibrate; Fibrosis; Hydrogen Peroxide; Ligands; Liver; Liver Cirrhosis; Male; Models, Biological; Oxidative Stress; Peroxisome Proliferators; PPAR alpha; Pyrimidines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Thioacetamide | 2004 |
Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones.
Topics: Adult; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Fatty Acid Desaturases; Female; Fenofibrate; Gene Expression Regulation; Humans; Hypoglycemic Agents; Male; Muscle Fibers, Skeletal; Peroxisome Proliferators; PPAR gamma; Pyrimidines; Receptors, Adiponectin; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosiglitazone; Statistics, Nonparametric; Stearoyl-CoA Desaturase; Thiazolidinediones; Troglitazone | 2005 |
Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells.
Topics: Amides; Animals; Aorta; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Down-Regulation; Enzyme Activation; Fenofibrate; Hydroxyeicosatetraenoic Acids; Male; Mixed Function Oxygenases; Muscle, Smooth, Vascular; Norepinephrine; Oligonucleotides, Antisense; Peroxisome Proliferators; Phospholipase D; Pyrimidines; Rabbits; Sulfones | 2005 |
Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Bezafibrate; Endothelial Cells; Enzyme Activation; Fenofibrate; Humans; Multienzyme Complexes; Nitric Oxide Synthase Type III; Phosphorylation; PPAR alpha; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Umbilical Veins; Up-Regulation | 2006 |
Agonists of the peroxisome proliferator-activated receptor alpha induce a fiber-type-selective transcriptional response in rat skeletal muscle.
Topics: Animals; Bezafibrate; Fatty Acids; Female; Fenofibrate; Gene Expression Profiling; Glucose; Hypolipidemic Agents; Liver; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; PPAR alpha; Pyrimidines; Rats; Rats, Inbred Strains; Rosiglitazone; Thiazolidinediones; Tretinoin | 2006 |
Wy-14,643 and fenofibrate inhibit mitochondrial respiration in isolated rat cardiac mitochondria.
Topics: Animals; Cell Respiration; Dose-Response Relationship, Drug; Fenofibrate; Male; Mitochondria, Heart; Myocardium; Pyrimidines; Rats; Rats, Wistar | 2006 |
Peroxisome proliferator-activated receptor alpha-independent effects of peroxisome proliferators on cysteinyl leukotriene production in mast cells.
Topics: Acyl-CoA Oxidase; Animals; Arachidonate 5-Lipoxygenase; Bone Marrow Cells; Cell Line, Tumor; Cells, Cultured; Cysteine; Fenofibrate; Hexosaminidases; Immunoglobulin E; Leukotrienes; Macrophages, Peritoneal; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxisome Proliferators; Phospholipases A; PPAR alpha; Pyrimidines; Rats | 2007 |
Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists.
Topics: Animals; Bezafibrate; Cells, Cultured; Fenofibrate; Gene Expression Profiling; Gene Expression Regulation; Hepatocytes; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; PPAR alpha; Pyrimidines | 2006 |
Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors.
Topics: Anti-Inflammatory Agents; Cell Proliferation; Cells, Cultured; Chromans; Cyclooxygenase 2; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Induction; Enzyme Inhibitors; Fenofibrate; Heme Oxygenase-1; Humans; Membrane Proteins; Metalloporphyrins; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Polymorphism, Genetic; PPAR alpha; PPAR gamma; Promoter Regions, Genetic; Protoporphyrins; Pyrimidines; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Time Factors; Transcription, Genetic; Transfection; Troglitazone; Tumor Necrosis Factor-alpha | 2007 |
Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells.
Topics: Anticholesteremic Agents; Arachidonic Acid; Cell Line; Cholesterol; Delta-5 Fatty Acid Desaturase; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Fatty Acid Desaturases; Fenofibrate; Humans; Linoleic Acid; Lipid Metabolism; Monocytes; Peroxisome Proliferators; PPAR alpha; PPAR gamma; Pyrimidines; RNA, Messenger; Simvastatin; Sterol Regulatory Element Binding Protein 1; Thiazolidinediones; Time Factors; Transcription, Genetic | 2007 |
Peroxisome proliferator-activated receptor alpha activation attenuated angiotensin type 1-mediated but enhanced angiotensin type 2-mediated hemodynamic effects to angiotensin II in the rat.
Topics: Angiotensin II; Animals; Cardiovascular Agents; Clofibrate; Fenofibrate; Hemodynamics; Male; Models, Animal; Nitric Oxide; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2008 |
Effect of peroxisome proliferator-activated receptor-alpha ligands in the interaction between adipocytes and macrophages in obese adipose tissue.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Inflammatory Agents; Cell Communication; Cell Line; Chemokine CCL2; Coculture Techniques; Disease Models, Animal; Fenofibrate; Ligands; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Obesity; Peritoneal Cavity; PPAR alpha; Pyrimidines; RNA, Messenger; Tumor Necrosis Factor-alpha | 2008 |
Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner.
Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytokines; Fenofibrate; Male; Mice; Mice, Inbred C57BL; Plasminogen Activator Inhibitor 1; PPAR alpha; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Transcription Factors; Transforming Growth Factor beta | 2009 |
Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis.
Topics: Apoptosis; Base Sequence; Cell Cycle; Cell Division; Cyclin D1; DNA Primers; Fenofibrate; Humans; Lymphoma, Mantle-Cell; NF-kappa B; PPAR alpha; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tumor Necrosis Factor-alpha | 2010 |
Fenofibrate but not fenofibric acid inhibits 11beta-hydroxysteroid dehydrogenase 1 in C2C12 myotubes.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Animals; Cell Line; Fenofibrate; Inhibitory Concentration 50; Mice; Muscles; PPAR alpha; Pyrimidines | 2010 |
Activation of peroxisome proliferator-activated receptor α in megakaryocytes reduces platelet-derived growth factor-BB in platelets.
Topics: Adult; Becaplermin; Blood Platelets; Cell Differentiation; Cell Line, Tumor; Dyslipidemias; Female; Fenofibrate; Gene Expression; Humans; Immunohistochemistry; Lipids; Male; Megakaryocytes; Middle Aged; Platelet-Derived Growth Factor; PPAR alpha; Proto-Oncogene Proteins c-sis; Pyrimidines; RNA, Messenger; Tetradecanoylphorbol Acetate | 2011 |
Effects of chronic systemic treatment with peroxisome proliferator-activated receptor α activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide in adult mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Disease Models, Animal; Fenofibrate; Fibric Acids; Inflammation Mediators; Injections, Intraventricular; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; PPAR alpha; Pyrimidines | 2011 |
Adiponectin reduces connective tissue growth factor in human hepatocytes which is already induced in non-fibrotic non-alcoholic steatohepatitis.
Topics: Adiponectin; Anticholesteremic Agents; Connective Tissue Growth Factor; Down-Regulation; Fatty Liver; Female; Fenofibrate; Hepatocytes; Humans; Male; Non-alcoholic Fatty Liver Disease; Phosphorylation; PPAR alpha; Primary Cell Culture; Pyrimidines; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2011 |
Fenofibrate down-regulates renal OCT2-mediated organic cation transport via PPARα-independent pathways.
Topics: Animals; Biological Transport; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cycloheximide; Down-Regulation; Epithelial Cells; Fenofibrate; Hypolipidemic Agents; Kidney Cortex; Male; Membrane Transport Proteins; Mice; Mice, Inbred ICR; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxazoles; PPAR alpha; Pyrimidines; Rabbits; Swine; Tyrosine | 2012 |
Wy14643 improves vascular function in the aorta of the spontaneously hypertensive rat mainly by activating peroxisome proliferator-activated receptors alpha.
Topics: Animals; Aorta, Thoracic; Fenofibrate; Hypertension; In Vitro Techniques; Male; Peroxisome Proliferators; PPAR alpha; PPAR gamma; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rosiglitazone; Thiazolidinediones; Vasoconstriction | 2012 |
PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Epilepsy, Frontal Lobe; Fenofibrate; Frontal Lobe; Inhibitory Postsynaptic Potentials; Male; Membrane Potentials; Mice; Nicotine; Patch-Clamp Techniques; Phosphorylation; PPAR alpha; Pyramidal Cells; Pyrimidines; Rats; Receptors, Nicotinic; Seizures | 2013 |
Fenofibrate Decreases Insulin Clearance and Insulin Secretion to Maintain Insulin Sensitivity.
Topics: Animals; Carcinoembryonic Antigen; Fenofibrate; Insulin; Insulin Resistance; Insulin Secretion; Mice; Mice, Knockout; PPAR alpha; Pyrimidines | 2016 |
Selective peroxisome proliferator-activated receptor-α modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-α pathway and improves lipid metabolism in mice.
Topics: Animals; Benzoxazoles; Butyrates; Cell Line; Drug Evaluation, Preclinical; Fenofibrate; Gene Expression; Hypolipidemic Agents; Lipid Metabolism; Liver; Male; Mice, Inbred C57BL; PPAR alpha; Pyrimidines; X-Box Binding Protein 1 | 2017 |
In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Local; Animals; Benzamides; Bridged Bicyclo Compounds; Cocaine; Conditioning, Operant; Disease Models, Animal; Fenofibrate; Hypolipidemic Agents; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Oxazoles; PPAR alpha; Pyrimidines; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tyrosine | 2017 |
Inhibition of JNK signalling mediates PPARα-dependent protection against intrahepatic cholestasis by fenofibrate.
Topics: 1-Naphthylisothiocyanate; Animals; Anthracenes; Cholestasis, Intrahepatic; Dose-Response Relationship, Drug; Fenofibrate; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; PPAR alpha; Protein Kinase Inhibitors; Pyrimidines; Signal Transduction; Structure-Activity Relationship | 2017 |
PPAR-α agonists acutely inhibit Ca
Topics: Animals; Antihypertensive Agents; Antioxidants; Aorta; Disease Models, Animal; Fenofibrate; Hydrogen Peroxide; Hypertension; Male; Oxidative Stress; Phospholipase A2 Inhibitors; Phospholipases A2, Calcium-Independent; PPAR alpha; Pyrimidines; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Vasoconstriction | 2018 |
Expression of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) in Non-Somatotroph Pituitary Tumours and the Effects of PPARα Agonists on MMQ Cells.
Topics: Adolescent; Adult; Aged; Cell Proliferation; Female; Fenofibrate; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Pituitary Neoplasms; PPAR alpha; Prolactinoma; Pyrimidines; Somatotrophs; Young Adult | 2018 |
Extraction of peroxisome proliferator-activated receptor α agonist-induced lipid metabolism-related and unrelated genes in rat liver and analysis of their genomic location.
Topics: Animals; Databases, Genetic; Epistasis, Genetic; Fenofibrate; Gene Expression; Genetic Association Studies; Genetic Loci; Information Storage and Retrieval; Lipid Metabolism; Liver; Male; PPAR alpha; Pyrimidines; Rats, Sprague-Dawley; Species Specificity | 2020 |
Peroxisome proliferator-activated receptor α agonist-induced histidine decarboxylase gene expression in the rat and mouse liver.
Topics: Animals; Cell Proliferation; Cells, Cultured; Clofibrate; Databases, Genetic; Fenofibrate; Gene Expression; Hepatocytes; Histidine Decarboxylase; Hypertrophy; Liver; Male; Mice; Mice, Inbred C57BL; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; Species Specificity | 2020 |